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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SEPT10-SH3RF3 (FusionGDB2 ID:80463)

Fusion Gene Summary for SEPT10-SH3RF3

Fusion gene summary

Fusion gene information	Fusion gene name: SEPT10-SH3RF3
	Fusion gene ID: 80463
		Hgene	Tgene
	Gene symbol	SEPT10	SH3RF3
	Gene ID	151011	344558
	Gene name	septin 10	SH3 domain containing ring finger 3
	Synonyms	SEPT10	POSH2\|SH3MD4
	Cytomap	2q13	2q13
	Type of gene	protein-coding	protein-coding
	Description	septin-10	E3 ubiquitin-protein ligase SH3RF3SH3 domain-containing RING finger protein 3SH3 multiple domains 4plenty of SH3s-2
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000334001, ENST00000356688, ENST00000397712, ENST00000397714, ENST00000415095, ENST00000437928, ENST00000545389, ENST00000468616,	ENST00000309415,
Fusion gene scores	* DoF score	5 X 5 X 5=125	2 X 3 X 2=12
	# samples	5	3
	** MAII score	log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SEPT10 [Title/Abstract] AND SH3RF3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SEPT10(110310664)-SH3RF3(110015046), # samples:2
Anticipated loss of major functional domain due to fusion event.	SEPT10-SH3RF3 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SEPT10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SH3RF3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-LA-A7SW-01A	SEPT10	chr2	110310664	-	SH3RF3	chr2	110015046	+
ChimerDB4	LUSC	TCGA-LA-A7SW	SEPT10	chr2	110310664	-	SH3RF3	chr2	110015046	+

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Fusion Gene ORF analysis for SEPT10-SH3RF3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000334001	ENST00000309415	SEPT10	chr2	110310664	-	SH3RF3	chr2	110015046	+
In-frame	ENST00000356688	ENST00000309415	SEPT10	chr2	110310664	-	SH3RF3	chr2	110015046	+
In-frame	ENST00000397712	ENST00000309415	SEPT10	chr2	110310664	-	SH3RF3	chr2	110015046	+
In-frame	ENST00000397714	ENST00000309415	SEPT10	chr2	110310664	-	SH3RF3	chr2	110015046	+
In-frame	ENST00000415095	ENST00000309415	SEPT10	chr2	110310664	-	SH3RF3	chr2	110015046	+
In-frame	ENST00000437928	ENST00000309415	SEPT10	chr2	110310664	-	SH3RF3	chr2	110015046	+
In-frame	ENST00000545389	ENST00000309415	SEPT10	chr2	110310664	-	SH3RF3	chr2	110015046	+
intron-3CDS	ENST00000468616	ENST00000309415	SEPT10	chr2	110310664	-	SH3RF3	chr2	110015046	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000356688	SEPT10	chr2	110310664	-	ENST00000309415	SH3RF3	chr2	110015046	+	3181	1477	304	3180	959
ENST00000397712	SEPT10	chr2	110310664	-	ENST00000309415	SH3RF3	chr2	110015046	+	3244	1540	367	3243	959
ENST00000397714	SEPT10	chr2	110310664	-	ENST00000309415	SH3RF3	chr2	110015046	+	2896	1192	88	2895	936
ENST00000437928	SEPT10	chr2	110310664	-	ENST00000309415	SH3RF3	chr2	110015046	+	3052	1348	196	3051	952
ENST00000545389	SEPT10	chr2	110310664	-	ENST00000309415	SH3RF3	chr2	110015046	+	2630	926	254	2629	792
ENST00000415095	SEPT10	chr2	110310664	-	ENST00000309415	SH3RF3	chr2	110015046	+	2873	1169	8	2872	955

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000356688	ENST00000309415	SEPT10	chr2	110310664	-	SH3RF3	chr2	110015046	+	0.001516391	0.9984836
ENST00000397712	ENST00000309415	SEPT10	chr2	110310664	-	SH3RF3	chr2	110015046	+	0.00158354	0.9984164
ENST00000397714	ENST00000309415	SEPT10	chr2	110310664	-	SH3RF3	chr2	110015046	+	0.001728879	0.9982711
ENST00000437928	ENST00000309415	SEPT10	chr2	110310664	-	SH3RF3	chr2	110015046	+	0.00235673	0.9976433
ENST00000545389	ENST00000309415	SEPT10	chr2	110310664	-	SH3RF3	chr2	110015046	+	0.013811275	0.9861887
ENST00000415095	ENST00000309415	SEPT10	chr2	110310664	-	SH3RF3	chr2	110015046	+	0.001347607	0.9986524

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Fusion Genomic Features for SEPT10-SH3RF3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SEPT10	chr2	110310663	-	SH3RF3	chr2	110015045	+	0.000288435	0.9997116
SEPT10	chr2	110310663	-	SH3RF3	chr2	110015045	+	0.000288435	0.9997116
SEPT10	chr2	110310663	-	SH3RF3	chr2	110015045	+	0.000288435	0.9997116
SEPT10	chr2	110310663	-	SH3RF3	chr2	110015045	+	0.000288435	0.9997116

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SEPT10-SH3RF3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:110310664/chr2:110015046)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SEPT10

chr2:110310664

chr2:110015046

ENST00000397712

63_329

387

455.0

Domain

Septin-type G

Hgene

SEPT10

chr2:110310664

chr2:110015046

ENST00000397714

63_329

364

432.0

Domain

Septin-type G

Hgene

SEPT10

chr2:110310664

chr2:110015046

ENST00000397712

209_217

387

455.0

Nucleotide binding

GTP

Hgene

SEPT10

chr2:110310664

chr2:110015046

ENST00000397714

209_217

364

432.0

Nucleotide binding

GTP

Hgene

SEPT10

chr2:110310664

chr2:110015046

ENST00000397712

125_128

387

455.0

Region

G3 motif

Hgene

SEPT10

chr2:110310664

chr2:110015046

ENST00000397712

208_211

387

455.0

Region

G4 motif

Hgene

SEPT10

chr2:110310664

chr2:110015046

ENST00000397712

73_80

387

455.0

Region

G1 motif

Hgene

SEPT10

chr2:110310664

chr2:110015046

ENST00000397714

125_128

364

432.0

Region

G3 motif

Hgene

SEPT10

chr2:110310664

chr2:110015046

ENST00000397714

208_211

364

432.0

Region

G4 motif

Hgene

SEPT10

chr2:110310664

chr2:110015046

ENST00000397714

73_80

364

432.0

Region

G1 motif

Tgene

SH3RF3

chr2:110310664

chr2:110015046

ENST00000309415

464_525

315

883.0

Domain

SH3 3

Tgene

SH3RF3

chr2:110310664

chr2:110015046

ENST00000309415

823_882

315

883.0

Domain

SH3 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SH3RF3

chr2:110310664

chr2:110015046

ENST00000309415

151_155

315

883.0

Compositional bias

Note=Poly-Gly

Tgene

SH3RF3

chr2:110310664

chr2:110015046

ENST00000309415

30_34

315

883.0

Compositional bias

Note=Poly-Arg

Tgene

SH3RF3

chr2:110310664

chr2:110015046

ENST00000309415

194_253

315

883.0

Domain

SH3 1

Tgene

SH3RF3

chr2:110310664

chr2:110015046

ENST00000309415

256_319

315

883.0

Domain

SH3 2

Tgene

SH3RF3

chr2:110310664

chr2:110015046

ENST00000309415

57_98

315

883.0

Zinc finger

RING-type

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Fusion Gene Sequence for SEPT10-SH3RF3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>80463_80463_1_SEPT10-SH3RF3_SEPT10_chr2_110310664_ENST00000356688_SH3RF3_chr2_110015046_ENST00000309415_length(transcript)=3181nt_BP=1477nt
GTCTTCCTGGAGTCCCAGCTCTCCTTCAGCCCGCCCCAACGCTGACGCTCAGTCCTCAGGCGTCGAGGGTAGCTCCTGTGAGGGGCTCGC
TTGGCGCAGGCAAAACGCTCAGCGCGCACCACAGGGCGTCCGCCCCAACCCCGCCCCCGGAGGCCTCCAGCTCGGCCCCGCCCCTGTCCC
TTCCCCGTCGCGGAGGCAGCCTAGCCTCGCGCCCCGCCCGTTGCTTCTGCCCTCCGGCCTTCCCGCCGCCGTCGCCGGGACCAGCCGCTC
GGGGCCGGGCTGATACAGCCGCTTCACCGTGCCCCTGCCCGCGACCATGGCCTCCTCCGAGGTGGCGCGGCACCTGCTCTTTCAGTCTCA
CATGGCAACGAAAACAACTTGTATGTCTTCACAAGGATCAGATGATGAACAGATAAAAAGAGAAAACATTCGTTCGTTGACTATGTCTGG
CCATGTTGGTTTTGAGAGTTTGCCTGATCAGCTGGTGAACAGATCCATTCAGCAAGGTTTCTGCTTTAATATTCTCTGTGTGGGGGAAAC
TGGAATTGGAAAATCAACACTGATTGACACATTGTTTAATACTAATTTTGAAGACTATGAATCCTCACATTTTTGCCCAAATGTTAAACT
TAAAGCTCAGACATATGAACTCCAGGAAAGTAATGTTCAATTGAAATTGACCATTGTGAATACAGTGGGATTTGGTGACCAAATAAATAA
AGAAGAGAGCTACCAACCAATAGTTGACTACATAGATGCTCAGTTTGAGGCCTATCTCCAAGAAGAACTGAAGATTAAGCGTTCTCTCTT
TACCTACCATGATTCTCGCATCCATGTGTGTCTCTACTTCATTTCACCGACAGGCCACTCTCTGAAGACACTTGATCTCTTAACCATGAA
GAACCTTGACAGCAAGGTAAACATTATACCAGTGATTGCCAAAGCAGATACGGTTTCTAAAACTGAATTACAGAAGTTTAAGATCAAGCT
CATGAGTGAATTGGTCAGCAATGGCGTCCAGATATACCAGTTCCCAACGGATGATGACACTATTGCTAAGGTCAACGCTGCAATGAATGG
ACAGTTGCCGTTTGCTGTTGTGGGAAGTATGGATGAGGTAAAAGTCGGAAACAAGATGGTCAAAGCTCGCCAGTACCCTTGGGGTGTTGT
ACAAGTGGAAAATGAAAACCACTGTGACTTTGTAAAGCTGCGGGAAATGCTCATTTGTACAAATATGGAGGACCTGCGAGAGCAGACCCA
TACCAGGCACTATGAGCTTTACAGGCGCTGCAAACTGGAGGAAATGGGCTTTACAGATGTGGGCCCAGAAAACAAGCCAGTCAGTGTTCA
AGAGACCTATGAAGCCAAAAGACATGAGTTCCATGGTGAACGTCAGAGGAAGGAAGAAGAAATGAAACAGATGTTTGTGCAGCGAGTAAA
GGAGAAAGAAGCCATATTGAAAGAAGCTGAGAGAGAGCTCAATGACTCCGCCAAGCAGCTCATTGAGATGGACAAGCCATGCCCAGCCGC
TGCATCCAGCTGCAATGCCTCCCTGCCCTCTGACTCCGGCGCTGTGGCCAGCGTGGCCCCAAGTCCCACTTTAAGCAGCTCAGGGGCGGT
CAGTGCCTTTCAGCGGCGTGTGGATGGCAAGAAGAACACCAAGAAACGCCACTCCTTCACCGCGCTCAGTGTGACGCACAGATCCTCCCA
GGCTGCCAGCCACAGGCATTCCATGGAAATTAGTGCTCCAGTGTTGATCAGCTCCAGCGATCCCCGAGCCGCGGCCAGGATTGGAGACCT
TGCTCATCTGTCGTGCGCTGCTCCCACCCAGGATGTCTCCTCCTCGGCGGGATCTACCCCCACGGCTGTCCCACGGGCTGCCTCGGTGTC
TGGAGAGCAGGGCACGCCTCCCAAGGTCCAGCTGCCCCTCAACGTGTACCTGGCGCTCTACGCCTACAAGCCCCAGAAGAGTGACGAGCT
GGAGCTGCACAAGGGAGAGATGTACCGGGTCCTCGAGAAGTGTCAGGATGGCTGGTTCAAGGGGGCGTCTCTGAGGACCGGGGTCTCTGG
GGTGTTCCCCGGAAACTACGTGACACCCGTTTCCAGGGTGCCTGCAGGAGGGGCAGGGCCGCCCCGGAATAATGTAGTCGGAGGGTCTCC
ACTGGCCAAAGGGATAACCACAACCATGCACCCAGGCAGTGGGAGTCTGAGCAGCCTGGCCACTGCCACCAGGCCCGCCCTGCCCATCAC
CACTCCCCAGGCCCACGCCCAGCACCCCACAGCCTCGCCCCCAACAGGCAGCTGTCTACGGCACTCAGCCCAGCCAACGGCCAGCCAAGC
CCGGAGCACCATTTCAACAGCTGCCCACTCTGCAGCCCAGGCTCAGGACCGGCCAACTGCCACCGTGTCACCCCTGCGCACCCAGAACTC
TCCATCCCGCCTGCCTGCCACCAGCCTCAGGCCCCACTCGGTGGTGTCCCCGCAGCACAGCCACCAGCCCCCGGTGCAGATGTGCCCACG
GCCGGCCATCCCCCTCACATCAGCAGCATCAGCCATCACACCTCCCAACGTCAGTGCCGCAAACCTCAACGGGGAGGCTGGAGGGGGGCC
CATCGGTGTTCTGTCCACATCCAGCCCCACCAACACGGGATGCAAACTAGACGAGAAGAAAAGTGAAAAGAAAGAGAAGAAGAGTGGGCT
CCTGAAGCTTCTAGCCGGAGCATCCACCAAGAAGAAGTCACGCTCCCCGCCATCTGTGTCTCCAACCCACGACCCCCAGGTGGCCGTGGA
CGCCCTGCTCCAAGGTGCAGTGGGCCCCGAAGTGTCCTCACTGTCCATCCACGGCAGGGCAGGGTCCTGCCCCATAGAGAGCGAGATGCA
GGGTGCCATGGGGATGGAGCCTCTGCACAGGAAGGCAGGCTCCTTGGATCTAAACTTCACATCTCCTTCCCGGCAAGCTCCGCTGTCCAT
GGCTGCCATCCGCCCCGAGCCCAAGCTGTTGCCCAGAGAGAGGTACCGCGTGGTGGTCTCGTACCCACCCCAGAGTGAGGCGGAGATCGA
GCTGAAGGAAGGCGACATCGTCTTTGTGCACAAGAAGCGTGAGGACGGCTGGTACAAGGGGACCCTGCAGCGGAACGGCCGCACAGGCCT

>80463_80463_1_SEPT10-SH3RF3_SEPT10_chr2_110310664_ENST00000356688_SH3RF3_chr2_110015046_ENST00000309415_length(amino acids)=959AA_BP=391
MPATMASSEVARHLLFQSHMATKTTCMSSQGSDDEQIKRENIRSLTMSGHVGFESLPDQLVNRSIQQGFCFNILCVGETGIGKSTLIDTL
FNTNFEDYESSHFCPNVKLKAQTYELQESNVQLKLTIVNTVGFGDQINKEESYQPIVDYIDAQFEAYLQEELKIKRSLFTYHDSRIHVCL
YFISPTGHSLKTLDLLTMKNLDSKVNIIPVIAKADTVSKTELQKFKIKLMSELVSNGVQIYQFPTDDDTIAKVNAAMNGQLPFAVVGSMD
EVKVGNKMVKARQYPWGVVQVENENHCDFVKLREMLICTNMEDLREQTHTRHYELYRRCKLEEMGFTDVGPENKPVSVQETYEAKRHEFH
GERQRKEEEMKQMFVQRVKEKEAILKEAERELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKK
NTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQL
PLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHP
GSGSLSSLATATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRP
HSVVSPQHSHQPPVQMCPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKK
KSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRAGSCPIESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLP

--------------------------------------------------------------
>80463_80463_2_SEPT10-SH3RF3_SEPT10_chr2_110310664_ENST00000397712_SH3RF3_chr2_110015046_ENST00000309415_length(transcript)=3244nt_BP=1540nt
CACTTCCGGCCTCGCGAGGGCCGCAATCACTGCTCCGCAGTTCCCGCCTGCATTCCTCGCGCCGTCTTCCTGGAGTCCCAGCTCTCCTTC
AGCCCGCCCCAACGCTGACGCTCAGTCCTCAGGCGTCGAGGGTAGCTCCTGTGAGGGGCTCGCTTGGCGCAGGCAAAACGCTCAGCGCGC
ACCACAGGGCGTCCGCCCCAACCCCGCCCCCGGAGGCCTCCAGCTCGGCCCCGCCCCTGTCCCTTCCCCGTCGCGGAGGCAGCCTAGCCT
CGCGCCCCGCCCGTTGCTTCTGCCCTCCGGCCTTCCCGCCGCCGTCGCCGGGACCAGCCGCTCGGGGCCGGGCTGATACAGCCGCTTCAC
CGTGCCCCTGCCCGCGACCATGGCCTCCTCCGAGGTGGCGCGGCACCTGCTCTTTCAGTCTCACATGGCAACGAAAACAACTTGTATGTC
TTCACAAGGATCAGATGATGAACAGATAAAAAGAGAAAACATTCGTTCGTTGACTATGTCTGGCCATGTTGGTTTTGAGAGTTTGCCTGA
TCAGCTGGTGAACAGATCCATTCAGCAAGGTTTCTGCTTTAATATTCTCTGTGTGGGGGAAACTGGAATTGGAAAATCAACACTGATTGA
CACATTGTTTAATACTAATTTTGAAGACTATGAATCCTCACATTTTTGCCCAAATGTTAAACTTAAAGCTCAGACATATGAACTCCAGGA
AAGTAATGTTCAATTGAAATTGACCATTGTGAATACAGTGGGATTTGGTGACCAAATAAATAAAGAAGAGAGCTACCAACCAATAGTTGA
CTACATAGATGCTCAGTTTGAGGCCTATCTCCAAGAAGAACTGAAGATTAAGCGTTCTCTCTTTACCTACCATGATTCTCGCATCCATGT
GTGTCTCTACTTCATTTCACCGACAGGCCACTCTCTGAAGACACTTGATCTCTTAACCATGAAGAACCTTGACAGCAAGGTAAACATTAT
ACCAGTGATTGCCAAAGCAGATACGGTTTCTAAAACTGAATTACAGAAGTTTAAGATCAAGCTCATGAGTGAATTGGTCAGCAATGGCGT
CCAGATATACCAGTTCCCAACGGATGATGACACTATTGCTAAGGTCAACGCTGCAATGAATGGACAGTTGCCGTTTGCTGTTGTGGGAAG
TATGGATGAGGTAAAAGTCGGAAACAAGATGGTCAAAGCTCGCCAGTACCCTTGGGGTGTTGTACAAGTGGAAAATGAAAACCACTGTGA
CTTTGTAAAGCTGCGGGAAATGCTCATTTGTACAAATATGGAGGACCTGCGAGAGCAGACCCATACCAGGCACTATGAGCTTTACAGGCG
CTGCAAACTGGAGGAAATGGGCTTTACAGATGTGGGCCCAGAAAACAAGCCAGTCAGTGTTCAAGAGACCTATGAAGCCAAAAGACATGA
GTTCCATGGTGAACGTCAGAGGAAGGAAGAAGAAATGAAACAGATGTTTGTGCAGCGAGTAAAGGAGAAAGAAGCCATATTGAAAGAAGC
TGAGAGAGAGCTCAATGACTCCGCCAAGCAGCTCATTGAGATGGACAAGCCATGCCCAGCCGCTGCATCCAGCTGCAATGCCTCCCTGCC
CTCTGACTCCGGCGCTGTGGCCAGCGTGGCCCCAAGTCCCACTTTAAGCAGCTCAGGGGCGGTCAGTGCCTTTCAGCGGCGTGTGGATGG
CAAGAAGAACACCAAGAAACGCCACTCCTTCACCGCGCTCAGTGTGACGCACAGATCCTCCCAGGCTGCCAGCCACAGGCATTCCATGGA
AATTAGTGCTCCAGTGTTGATCAGCTCCAGCGATCCCCGAGCCGCGGCCAGGATTGGAGACCTTGCTCATCTGTCGTGCGCTGCTCCCAC
CCAGGATGTCTCCTCCTCGGCGGGATCTACCCCCACGGCTGTCCCACGGGCTGCCTCGGTGTCTGGAGAGCAGGGCACGCCTCCCAAGGT
CCAGCTGCCCCTCAACGTGTACCTGGCGCTCTACGCCTACAAGCCCCAGAAGAGTGACGAGCTGGAGCTGCACAAGGGAGAGATGTACCG
GGTCCTCGAGAAGTGTCAGGATGGCTGGTTCAAGGGGGCGTCTCTGAGGACCGGGGTCTCTGGGGTGTTCCCCGGAAACTACGTGACACC
CGTTTCCAGGGTGCCTGCAGGAGGGGCAGGGCCGCCCCGGAATAATGTAGTCGGAGGGTCTCCACTGGCCAAAGGGATAACCACAACCAT
GCACCCAGGCAGTGGGAGTCTGAGCAGCCTGGCCACTGCCACCAGGCCCGCCCTGCCCATCACCACTCCCCAGGCCCACGCCCAGCACCC
CACAGCCTCGCCCCCAACAGGCAGCTGTCTACGGCACTCAGCCCAGCCAACGGCCAGCCAAGCCCGGAGCACCATTTCAACAGCTGCCCA
CTCTGCAGCCCAGGCTCAGGACCGGCCAACTGCCACCGTGTCACCCCTGCGCACCCAGAACTCTCCATCCCGCCTGCCTGCCACCAGCCT
CAGGCCCCACTCGGTGGTGTCCCCGCAGCACAGCCACCAGCCCCCGGTGCAGATGTGCCCACGGCCGGCCATCCCCCTCACATCAGCAGC
ATCAGCCATCACACCTCCCAACGTCAGTGCCGCAAACCTCAACGGGGAGGCTGGAGGGGGGCCCATCGGTGTTCTGTCCACATCCAGCCC
CACCAACACGGGATGCAAACTAGACGAGAAGAAAAGTGAAAAGAAAGAGAAGAAGAGTGGGCTCCTGAAGCTTCTAGCCGGAGCATCCAC
CAAGAAGAAGTCACGCTCCCCGCCATCTGTGTCTCCAACCCACGACCCCCAGGTGGCCGTGGACGCCCTGCTCCAAGGTGCAGTGGGCCC
CGAAGTGTCCTCACTGTCCATCCACGGCAGGGCAGGGTCCTGCCCCATAGAGAGCGAGATGCAGGGTGCCATGGGGATGGAGCCTCTGCA
CAGGAAGGCAGGCTCCTTGGATCTAAACTTCACATCTCCTTCCCGGCAAGCTCCGCTGTCCATGGCTGCCATCCGCCCCGAGCCCAAGCT
GTTGCCCAGAGAGAGGTACCGCGTGGTGGTCTCGTACCCACCCCAGAGTGAGGCGGAGATCGAGCTGAAGGAAGGCGACATCGTCTTTGT
GCACAAGAAGCGTGAGGACGGCTGGTACAAGGGGACCCTGCAGCGGAACGGCCGCACAGGCCTCTTCCCGGGCAGCTTCGTCGAGAGCTT

>80463_80463_2_SEPT10-SH3RF3_SEPT10_chr2_110310664_ENST00000397712_SH3RF3_chr2_110015046_ENST00000309415_length(amino acids)=959AA_BP=391
MPATMASSEVARHLLFQSHMATKTTCMSSQGSDDEQIKRENIRSLTMSGHVGFESLPDQLVNRSIQQGFCFNILCVGETGIGKSTLIDTL
FNTNFEDYESSHFCPNVKLKAQTYELQESNVQLKLTIVNTVGFGDQINKEESYQPIVDYIDAQFEAYLQEELKIKRSLFTYHDSRIHVCL
YFISPTGHSLKTLDLLTMKNLDSKVNIIPVIAKADTVSKTELQKFKIKLMSELVSNGVQIYQFPTDDDTIAKVNAAMNGQLPFAVVGSMD
EVKVGNKMVKARQYPWGVVQVENENHCDFVKLREMLICTNMEDLREQTHTRHYELYRRCKLEEMGFTDVGPENKPVSVQETYEAKRHEFH
GERQRKEEEMKQMFVQRVKEKEAILKEAERELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKK
NTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQL
PLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHP
GSGSLSSLATATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRP
HSVVSPQHSHQPPVQMCPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKK
KSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRAGSCPIESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLP

--------------------------------------------------------------
>80463_80463_3_SEPT10-SH3RF3_SEPT10_chr2_110310664_ENST00000397714_SH3RF3_chr2_110015046_ENST00000309415_length(transcript)=2896nt_BP=1192nt
CCCGTTGCTTCTGCCCTCCGGCCTTCCCGCCGCCGTCGCCGGGACCAGCCGCTCGGGGCCGGGCTGATACAGCCGCTTCACCGTGCCCCT
GCCCGCGACCATGGCCTCCTCCGAGGTGGCGCGGCACCTGAAAAGAGAAAACATTCGTTCGTTGACTATGTCTGGCCATGTTGGTTTTGA
GAGTTTGCCTGATCAGCTGGTGAACAGATCCATTCAGCAAGGTTTCTGCTTTAATATTCTCTGTGTGGGGGAAACTGGAATTGGAAAATC
AACACTGATTGACACATTGTTTAATACTAATTTTGAAGACTATGAATCCTCACATTTTTGCCCAAATGTTAAACTTAAAGCTCAGACATA
TGAACTCCAGGAAAGTAATGTTCAATTGAAATTGACCATTGTGAATACAGTGGGATTTGGTGACCAAATAAATAAAGAAGAGAGCTACCA
ACCAATAGTTGACTACATAGATGCTCAGTTTGAGGCCTATCTCCAAGAAGAACTGAAGATTAAGCGTTCTCTCTTTACCTACCATGATTC
TCGCATCCATGTGTGTCTCTACTTCATTTCACCGACAGGCCACTCTCTGAAGACACTTGATCTCTTAACCATGAAGAACCTTGACAGCAA
GGTAAACATTATACCAGTGATTGCCAAAGCAGATACGGTTTCTAAAACTGAATTACAGAAGTTTAAGATCAAGCTCATGAGTGAATTGGT
CAGCAATGGCGTCCAGATATACCAGTTCCCAACGGATGATGACACTATTGCTAAGGTCAACGCTGCAATGAATGGACAGTTGCCGTTTGC
TGTTGTGGGAAGTATGGATGAGGTAAAAGTCGGAAACAAGATGGTCAAAGCTCGCCAGTACCCTTGGGGTGTTGTACAAGTGGAAAATGA
AAACCACTGTGACTTTGTAAAGCTGCGGGAAATGCTCATTTGTACAAATATGGAGGACCTGCGAGAGCAGACCCATACCAGGCACTATGA
GCTTTACAGGCGCTGCAAACTGGAGGAAATGGGCTTTACAGATGTGGGCCCAGAAAACAAGCCAGTCAGTGTTCAAGAGACCTATGAAGC
CAAAAGACATGAGTTCCATGGTGAACGTCAGAGGAAGGAAGAAGAAATGAAACAGATGTTTGTGCAGCGAGTAAAGGAGAAAGAAGCCAT
ATTGAAAGAAGCTGAGAGAGAGCTCAATGACTCCGCCAAGCAGCTCATTGAGATGGACAAGCCATGCCCAGCCGCTGCATCCAGCTGCAA
TGCCTCCCTGCCCTCTGACTCCGGCGCTGTGGCCAGCGTGGCCCCAAGTCCCACTTTAAGCAGCTCAGGGGCGGTCAGTGCCTTTCAGCG
GCGTGTGGATGGCAAGAAGAACACCAAGAAACGCCACTCCTTCACCGCGCTCAGTGTGACGCACAGATCCTCCCAGGCTGCCAGCCACAG
GCATTCCATGGAAATTAGTGCTCCAGTGTTGATCAGCTCCAGCGATCCCCGAGCCGCGGCCAGGATTGGAGACCTTGCTCATCTGTCGTG
CGCTGCTCCCACCCAGGATGTCTCCTCCTCGGCGGGATCTACCCCCACGGCTGTCCCACGGGCTGCCTCGGTGTCTGGAGAGCAGGGCAC
GCCTCCCAAGGTCCAGCTGCCCCTCAACGTGTACCTGGCGCTCTACGCCTACAAGCCCCAGAAGAGTGACGAGCTGGAGCTGCACAAGGG
AGAGATGTACCGGGTCCTCGAGAAGTGTCAGGATGGCTGGTTCAAGGGGGCGTCTCTGAGGACCGGGGTCTCTGGGGTGTTCCCCGGAAA
CTACGTGACACCCGTTTCCAGGGTGCCTGCAGGAGGGGCAGGGCCGCCCCGGAATAATGTAGTCGGAGGGTCTCCACTGGCCAAAGGGAT
AACCACAACCATGCACCCAGGCAGTGGGAGTCTGAGCAGCCTGGCCACTGCCACCAGGCCCGCCCTGCCCATCACCACTCCCCAGGCCCA
CGCCCAGCACCCCACAGCCTCGCCCCCAACAGGCAGCTGTCTACGGCACTCAGCCCAGCCAACGGCCAGCCAAGCCCGGAGCACCATTTC
AACAGCTGCCCACTCTGCAGCCCAGGCTCAGGACCGGCCAACTGCCACCGTGTCACCCCTGCGCACCCAGAACTCTCCATCCCGCCTGCC
TGCCACCAGCCTCAGGCCCCACTCGGTGGTGTCCCCGCAGCACAGCCACCAGCCCCCGGTGCAGATGTGCCCACGGCCGGCCATCCCCCT
CACATCAGCAGCATCAGCCATCACACCTCCCAACGTCAGTGCCGCAAACCTCAACGGGGAGGCTGGAGGGGGGCCCATCGGTGTTCTGTC
CACATCCAGCCCCACCAACACGGGATGCAAACTAGACGAGAAGAAAAGTGAAAAGAAAGAGAAGAAGAGTGGGCTCCTGAAGCTTCTAGC
CGGAGCATCCACCAAGAAGAAGTCACGCTCCCCGCCATCTGTGTCTCCAACCCACGACCCCCAGGTGGCCGTGGACGCCCTGCTCCAAGG
TGCAGTGGGCCCCGAAGTGTCCTCACTGTCCATCCACGGCAGGGCAGGGTCCTGCCCCATAGAGAGCGAGATGCAGGGTGCCATGGGGAT
GGAGCCTCTGCACAGGAAGGCAGGCTCCTTGGATCTAAACTTCACATCTCCTTCCCGGCAAGCTCCGCTGTCCATGGCTGCCATCCGCCC
CGAGCCCAAGCTGTTGCCCAGAGAGAGGTACCGCGTGGTGGTCTCGTACCCACCCCAGAGTGAGGCGGAGATCGAGCTGAAGGAAGGCGA
CATCGTCTTTGTGCACAAGAAGCGTGAGGACGGCTGGTACAAGGGGACCCTGCAGCGGAACGGCCGCACAGGCCTCTTCCCGGGCAGCTT

>80463_80463_3_SEPT10-SH3RF3_SEPT10_chr2_110310664_ENST00000397714_SH3RF3_chr2_110015046_ENST00000309415_length(amino acids)=936AA_BP=368
MPATMASSEVARHLKRENIRSLTMSGHVGFESLPDQLVNRSIQQGFCFNILCVGETGIGKSTLIDTLFNTNFEDYESSHFCPNVKLKAQT
YELQESNVQLKLTIVNTVGFGDQINKEESYQPIVDYIDAQFEAYLQEELKIKRSLFTYHDSRIHVCLYFISPTGHSLKTLDLLTMKNLDS
KVNIIPVIAKADTVSKTELQKFKIKLMSELVSNGVQIYQFPTDDDTIAKVNAAMNGQLPFAVVGSMDEVKVGNKMVKARQYPWGVVQVEN
ENHCDFVKLREMLICTNMEDLREQTHTRHYELYRRCKLEEMGFTDVGPENKPVSVQETYEAKRHEFHGERQRKEEEMKQMFVQRVKEKEA
ILKEAERELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASH
RHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHK
GEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSSLATATRPALPITTPQA
HAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAIP
LTSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQ
GAVGPEVSSLSIHGRAGSCPIESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVVVSYPPQSEAEIELKEG

--------------------------------------------------------------
>80463_80463_4_SEPT10-SH3RF3_SEPT10_chr2_110310664_ENST00000415095_SH3RF3_chr2_110015046_ENST00000309415_length(transcript)=2873nt_BP=1169nt
CCGCGACCATGGCCTCCTCCGAGGTGGCGCGGCACCTGCTCTTTCAGTCTCACATGGCAACGAAAACAACTTGTATGTCTTCACAAGGAT
CAGATGATGAACAGATAAAAAGAGAAAACATTCGTTCGTTGACTATGTCTGGCCATGTTGGTTTTGAGAGTTTGCCTGATCAGCTGGTGA
ACAGATCCATTCAGCAAGGTTTCTGCTTTAATATTCTCTGTGTGGGGGAAACTGGAATTGGAAAATCAACACTGATTGACACATTGTTTA
ATACTAATTTTGAAGACTATGAATCCTCACATTTTTGCCCAAATGTTAAACTTAAAGCTCAGACATATGAACTCCAGGAAAGTAATGTTC
AATTGAAATTGACCATTGTGAATACAGTGGGATTTGGTGACCAAATAAATAAAGAAGAGAGCTACCAACCAATAGTTGACTACATAGATG
CTCAGTTTGAGGCCTATCTCCAAGAAGAACTGAAGATTAAGCGTTCTCTCTTTACCTACCATGATTCTCGCATCCATGTGTGTCTCTACT
TCATTTCACCGACAGGCCACTCTCTGAAGACACTTGATCTCTTAACCATGAAGAACCTTGACAGCAAGGTAAACATTATACCAGTGATTG
CCAAAGCAGATACGGTTTCTAAAACTGAATTACAGAAGTTTAAGATCAAGCTCATGAGTGAATTGGTCAGCAATGGCGTCCAGATATACC
AGTTCCCAACGGATGATGACACTATTGCTAAGGTCAACGCTGCAATGAATGGACAGTTGCCGTTTGCTGTTGTGGGAAGTATGGATGAGG
TAAAAGTCGGAAACAAGATGGTCAAAGCTCGCCAGTACCCTTGGGGTGTTGTACAAGTGGAAAATGAAAACCACTGTGACTTTGTAAAGC
TGCGGGAAATGCTCATTTGTACAAATATGGAGGACCTGCGAGAGCAGACCCATACCAGGCACTATGAGCTTTACAGGCGCTGCAAACTGG
AGGAAATGGGCTTTACAGATGTGGGCCCAGAAAACAAGCCAGTCAGTGTTCAAGAGACCTATGAAGCCAAAAGACATGAGTTCCATGGTG
AACGTCAGAGGAAGGAAGAAGAAATGAAACAGATGTTTGTGCAGCGAGTAAAGGAGAAAGAAGCCATATTGAAAGAAGCTGAGAGAGAGC
TCAATGACTCCGCCAAGCAGCTCATTGAGATGGACAAGCCATGCCCAGCCGCTGCATCCAGCTGCAATGCCTCCCTGCCCTCTGACTCCG
GCGCTGTGGCCAGCGTGGCCCCAAGTCCCACTTTAAGCAGCTCAGGGGCGGTCAGTGCCTTTCAGCGGCGTGTGGATGGCAAGAAGAACA
CCAAGAAACGCCACTCCTTCACCGCGCTCAGTGTGACGCACAGATCCTCCCAGGCTGCCAGCCACAGGCATTCCATGGAAATTAGTGCTC
CAGTGTTGATCAGCTCCAGCGATCCCCGAGCCGCGGCCAGGATTGGAGACCTTGCTCATCTGTCGTGCGCTGCTCCCACCCAGGATGTCT
CCTCCTCGGCGGGATCTACCCCCACGGCTGTCCCACGGGCTGCCTCGGTGTCTGGAGAGCAGGGCACGCCTCCCAAGGTCCAGCTGCCCC
TCAACGTGTACCTGGCGCTCTACGCCTACAAGCCCCAGAAGAGTGACGAGCTGGAGCTGCACAAGGGAGAGATGTACCGGGTCCTCGAGA
AGTGTCAGGATGGCTGGTTCAAGGGGGCGTCTCTGAGGACCGGGGTCTCTGGGGTGTTCCCCGGAAACTACGTGACACCCGTTTCCAGGG
TGCCTGCAGGAGGGGCAGGGCCGCCCCGGAATAATGTAGTCGGAGGGTCTCCACTGGCCAAAGGGATAACCACAACCATGCACCCAGGCA
GTGGGAGTCTGAGCAGCCTGGCCACTGCCACCAGGCCCGCCCTGCCCATCACCACTCCCCAGGCCCACGCCCAGCACCCCACAGCCTCGC
CCCCAACAGGCAGCTGTCTACGGCACTCAGCCCAGCCAACGGCCAGCCAAGCCCGGAGCACCATTTCAACAGCTGCCCACTCTGCAGCCC
AGGCTCAGGACCGGCCAACTGCCACCGTGTCACCCCTGCGCACCCAGAACTCTCCATCCCGCCTGCCTGCCACCAGCCTCAGGCCCCACT
CGGTGGTGTCCCCGCAGCACAGCCACCAGCCCCCGGTGCAGATGTGCCCACGGCCGGCCATCCCCCTCACATCAGCAGCATCAGCCATCA
CACCTCCCAACGTCAGTGCCGCAAACCTCAACGGGGAGGCTGGAGGGGGGCCCATCGGTGTTCTGTCCACATCCAGCCCCACCAACACGG
GATGCAAACTAGACGAGAAGAAAAGTGAAAAGAAAGAGAAGAAGAGTGGGCTCCTGAAGCTTCTAGCCGGAGCATCCACCAAGAAGAAGT
CACGCTCCCCGCCATCTGTGTCTCCAACCCACGACCCCCAGGTGGCCGTGGACGCCCTGCTCCAAGGTGCAGTGGGCCCCGAAGTGTCCT
CACTGTCCATCCACGGCAGGGCAGGGTCCTGCCCCATAGAGAGCGAGATGCAGGGTGCCATGGGGATGGAGCCTCTGCACAGGAAGGCAG
GCTCCTTGGATCTAAACTTCACATCTCCTTCCCGGCAAGCTCCGCTGTCCATGGCTGCCATCCGCCCCGAGCCCAAGCTGTTGCCCAGAG
AGAGGTACCGCGTGGTGGTCTCGTACCCACCCCAGAGTGAGGCGGAGATCGAGCTGAAGGAAGGCGACATCGTCTTTGTGCACAAGAAGC

>80463_80463_4_SEPT10-SH3RF3_SEPT10_chr2_110310664_ENST00000415095_SH3RF3_chr2_110015046_ENST00000309415_length(amino acids)=955AA_BP=387
MASSEVARHLLFQSHMATKTTCMSSQGSDDEQIKRENIRSLTMSGHVGFESLPDQLVNRSIQQGFCFNILCVGETGIGKSTLIDTLFNTN
FEDYESSHFCPNVKLKAQTYELQESNVQLKLTIVNTVGFGDQINKEESYQPIVDYIDAQFEAYLQEELKIKRSLFTYHDSRIHVCLYFIS
PTGHSLKTLDLLTMKNLDSKVNIIPVIAKADTVSKTELQKFKIKLMSELVSNGVQIYQFPTDDDTIAKVNAAMNGQLPFAVVGSMDEVKV
GNKMVKARQYPWGVVQVENENHCDFVKLREMLICTNMEDLREQTHTRHYELYRRCKLEEMGFTDVGPENKPVSVQETYEAKRHEFHGERQ
RKEEEMKQMFVQRVKEKEAILKEAERELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKK
RHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNV
YLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGS
LSSLATATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVV
SPQHSHQPPVQMCPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSRS
PPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRAGSCPIESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERY

--------------------------------------------------------------
>80463_80463_5_SEPT10-SH3RF3_SEPT10_chr2_110310664_ENST00000437928_SH3RF3_chr2_110015046_ENST00000309415_length(transcript)=3052nt_BP=1348nt
GCCCTCCGGCCTTCCCGCCGCCGTCGCCGGGACCAGCCGCTCGGGGCCGGGCTGATACAGCCGCTTCACCGTGCCCCTGCCCGCGACCAT
GGCCTCCTCCGAGGTGGCGCGGCACCTGTGACGTCTCTCCAGTGACCTTAGTTTGAGTCACTTGGACTCAGAATCATGAAGTCAGCTTCT
TGCAGCCTCACCTTTTCTGCTGTCCTTGCATTTACATCTCTTTCAGTCTCACATGGCAACGAAAACAACTTGTATGTCTTCACAAGGATC
AGATGATGAACAGATAAAAAGAGAAAACATTCGTTCGTTGACTATGTCTGGCCATGTTGGTTTTGAGAGTTTGCCTGATCAGCTGGTGAA
CAGATCCATTCAGCAAGGTTTCTGCTTTAATATTCTCTGTGTGGGGGAAACTGGAATTGGAAAATCAACACTGATTGACACATTGTTTAA
TACTAATTTTGAAGACTATGAATCCTCACATTTTTGCCCAAATGTTAAACTTAAAGCTCAGACATATGAACTCCAGGAAAGTAATGTTCA
ATTGAAATTGACCATTGTGAATACAGTGGGATTTGGTGACCAAATAAATAAAGAAGAGAGCTACCAACCAATAGTTGACTACATAGATGC
TCAGTTTGAGGCCTATCTCCAAGAAGAACTGAAGATTAAGCGTTCTCTCTTTACCTACCATGATTCTCGCATCCATGTGTGTCTCTACTT
CATTTCACCGACAGGCCACTCTCTGAAGACACTTGATCTCTTAACCATGAAGAACCTTGACAGCAAGGTAAACATTATACCAGTGATTGC
CAAAGCAGATACGGTTTCTAAAACTGAATTACAGAAGTTTAAGATCAAGCTCATGAGTGAATTGGTCAGCAATGGCGTCCAGATATACCA
GTTCCCAACGGATGATGACACTATTGCTAAGGTCAACGCTGCAATGAATGGACAGTTGCCGTTTGCTGTTGTGGGAAGTATGGATGAGGT
AAAAGTCGGAAACAAGATGGTCAAAGCTCGCCAGTACCCTTGGGGTGTTGTACAAGTGGAAAATGAAAACCACTGTGACTTTGTAAAGCT
GCGGGAAATGCTCATTTGTACAAATATGGAGGACCTGCGAGAGCAGACCCATACCAGGCACTATGAGCTTTACAGGCGCTGCAAACTGGA
GGAAATGGGCTTTACAGATGTGGGCCCAGAAAACAAGCCAGTCAGTGTTCAAGAGACCTATGAAGCCAAAAGACATGAGTTCCATGGTGA
ACGTCAGAGGAAGGAAGAAGAAATGAAACAGATGTTTGTGCAGCGAGTAAAGGAGAAAGAAGCCATATTGAAAGAAGCTGAGAGAGAGCT
CAATGACTCCGCCAAGCAGCTCATTGAGATGGACAAGCCATGCCCAGCCGCTGCATCCAGCTGCAATGCCTCCCTGCCCTCTGACTCCGG
CGCTGTGGCCAGCGTGGCCCCAAGTCCCACTTTAAGCAGCTCAGGGGCGGTCAGTGCCTTTCAGCGGCGTGTGGATGGCAAGAAGAACAC
CAAGAAACGCCACTCCTTCACCGCGCTCAGTGTGACGCACAGATCCTCCCAGGCTGCCAGCCACAGGCATTCCATGGAAATTAGTGCTCC
AGTGTTGATCAGCTCCAGCGATCCCCGAGCCGCGGCCAGGATTGGAGACCTTGCTCATCTGTCGTGCGCTGCTCCCACCCAGGATGTCTC
CTCCTCGGCGGGATCTACCCCCACGGCTGTCCCACGGGCTGCCTCGGTGTCTGGAGAGCAGGGCACGCCTCCCAAGGTCCAGCTGCCCCT
CAACGTGTACCTGGCGCTCTACGCCTACAAGCCCCAGAAGAGTGACGAGCTGGAGCTGCACAAGGGAGAGATGTACCGGGTCCTCGAGAA
GTGTCAGGATGGCTGGTTCAAGGGGGCGTCTCTGAGGACCGGGGTCTCTGGGGTGTTCCCCGGAAACTACGTGACACCCGTTTCCAGGGT
GCCTGCAGGAGGGGCAGGGCCGCCCCGGAATAATGTAGTCGGAGGGTCTCCACTGGCCAAAGGGATAACCACAACCATGCACCCAGGCAG
TGGGAGTCTGAGCAGCCTGGCCACTGCCACCAGGCCCGCCCTGCCCATCACCACTCCCCAGGCCCACGCCCAGCACCCCACAGCCTCGCC
CCCAACAGGCAGCTGTCTACGGCACTCAGCCCAGCCAACGGCCAGCCAAGCCCGGAGCACCATTTCAACAGCTGCCCACTCTGCAGCCCA
GGCTCAGGACCGGCCAACTGCCACCGTGTCACCCCTGCGCACCCAGAACTCTCCATCCCGCCTGCCTGCCACCAGCCTCAGGCCCCACTC
GGTGGTGTCCCCGCAGCACAGCCACCAGCCCCCGGTGCAGATGTGCCCACGGCCGGCCATCCCCCTCACATCAGCAGCATCAGCCATCAC
ACCTCCCAACGTCAGTGCCGCAAACCTCAACGGGGAGGCTGGAGGGGGGCCCATCGGTGTTCTGTCCACATCCAGCCCCACCAACACGGG
ATGCAAACTAGACGAGAAGAAAAGTGAAAAGAAAGAGAAGAAGAGTGGGCTCCTGAAGCTTCTAGCCGGAGCATCCACCAAGAAGAAGTC
ACGCTCCCCGCCATCTGTGTCTCCAACCCACGACCCCCAGGTGGCCGTGGACGCCCTGCTCCAAGGTGCAGTGGGCCCCGAAGTGTCCTC
ACTGTCCATCCACGGCAGGGCAGGGTCCTGCCCCATAGAGAGCGAGATGCAGGGTGCCATGGGGATGGAGCCTCTGCACAGGAAGGCAGG
CTCCTTGGATCTAAACTTCACATCTCCTTCCCGGCAAGCTCCGCTGTCCATGGCTGCCATCCGCCCCGAGCCCAAGCTGTTGCCCAGAGA
GAGGTACCGCGTGGTGGTCTCGTACCCACCCCAGAGTGAGGCGGAGATCGAGCTGAAGGAAGGCGACATCGTCTTTGTGCACAAGAAGCG

>80463_80463_5_SEPT10-SH3RF3_SEPT10_chr2_110310664_ENST00000437928_SH3RF3_chr2_110015046_ENST00000309415_length(amino acids)=952AA_BP=384
MLSLHLHLFQSHMATKTTCMSSQGSDDEQIKRENIRSLTMSGHVGFESLPDQLVNRSIQQGFCFNILCVGETGIGKSTLIDTLFNTNFED
YESSHFCPNVKLKAQTYELQESNVQLKLTIVNTVGFGDQINKEESYQPIVDYIDAQFEAYLQEELKIKRSLFTYHDSRIHVCLYFISPTG
HSLKTLDLLTMKNLDSKVNIIPVIAKADTVSKTELQKFKIKLMSELVSNGVQIYQFPTDDDTIAKVNAAMNGQLPFAVVGSMDEVKVGNK
MVKARQYPWGVVQVENENHCDFVKLREMLICTNMEDLREQTHTRHYELYRRCKLEEMGFTDVGPENKPVSVQETYEAKRHEFHGERQRKE
EEMKQMFVQRVKEKEAILKEAERELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSGAVSAFQRRVDGKKNTKKRHS
FTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAASVSGEQGTPPKVQLPLNVYLA
LYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGGSPLAKGITTTMHPGSGSLSS
LATATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQNSPSRLPATSLRPHSVVSPQ
HSHQPPVQMCPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKSGLLKLLAGASTKKKSRSPPS
VSPTHDPQVAVDALLQGAVGPEVSSLSIHGRAGSCPIESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPLSMAAIRPEPKLLPRERYRVV

--------------------------------------------------------------
>80463_80463_6_SEPT10-SH3RF3_SEPT10_chr2_110310664_ENST00000545389_SH3RF3_chr2_110015046_ENST00000309415_length(transcript)=2630nt_BP=926nt
AGTCCTCAGGCGTCGAGGGTAGCTCCTGTGAGGGGCTCGCTTGGCGCAGGCAAAACGCTCAGCGCGCACCACAGGGCGTCCGCCCCAACC
CCGCCCCCGGAGGCCTCCAGCTCGGCCCCGCCCCTGTCCCTTCCCCGTCGCGGAGGCAGCCTAGCCTCGCGCCCCGCCCGTTGCTTCTGC
CCTCCGGCCTTCCCGCCGCCGTCGCCGGGACCAGCCGCTCGGGGCCGGGCTGATACAGCCGCTTCACCGTGCCCCTGCCCGCGACCATGG
CCTCCTCCGAGGTGGCGCGGCACCTGCTCTTTCAGTCTCACATGGCAACGAAAACAACTTGTATGTCTTCACAAGGATCAGATGATGAAC
AGATAGTAAACATTATACCAGTGATTGCCAAAGCAGATACGGTTTCTAAAACTGAATTACAGAAGTTTAAGATCAAGCTCATGAGTGAAT
TGGTCAGCAATGGCGTCCAGATATACCAGTTCCCAACGGATGATGACACTATTGCTAAGGTCAACGCTGCAATGAATGGACAGTTGCCGT
TTGCTGTTGTGGGAAGTATGGATGAGGTAAAAGTCGGAAACAAGATGGTCAAAGCTCGCCAGTACCCTTGGGGTGTTGTACAAGTGGAAA
ATGAAAACCACTGTGACTTTGTAAAGCTGCGGGAAATGCTCATTTGTACAAATATGGAGGACCTGCGAGAGCAGACCCATACCAGGCACT
ATGAGCTTTACAGGCGCTGCAAACTGGAGGAAATGGGCTTTACAGATGTGGGCCCAGAAAACAAGCCAGTCAGTGTTCAAGAGACCTATG
AAGCCAAAAGACATGAGTTCCATGGTGAACGTCAGAGGAAGGAAGAAGAAATGAAACAGATGTTTGTGCAGCGAGTAAAGGAGAAAGAAG
CCATATTGAAAGAAGCTGAGAGAGAGCTCAATGACTCCGCCAAGCAGCTCATTGAGATGGACAAGCCATGCCCAGCCGCTGCATCCAGCT
GCAATGCCTCCCTGCCCTCTGACTCCGGCGCTGTGGCCAGCGTGGCCCCAAGTCCCACTTTAAGCAGCTCAGGGGCGGTCAGTGCCTTTC
AGCGGCGTGTGGATGGCAAGAAGAACACCAAGAAACGCCACTCCTTCACCGCGCTCAGTGTGACGCACAGATCCTCCCAGGCTGCCAGCC
ACAGGCATTCCATGGAAATTAGTGCTCCAGTGTTGATCAGCTCCAGCGATCCCCGAGCCGCGGCCAGGATTGGAGACCTTGCTCATCTGT
CGTGCGCTGCTCCCACCCAGGATGTCTCCTCCTCGGCGGGATCTACCCCCACGGCTGTCCCACGGGCTGCCTCGGTGTCTGGAGAGCAGG
GCACGCCTCCCAAGGTCCAGCTGCCCCTCAACGTGTACCTGGCGCTCTACGCCTACAAGCCCCAGAAGAGTGACGAGCTGGAGCTGCACA
AGGGAGAGATGTACCGGGTCCTCGAGAAGTGTCAGGATGGCTGGTTCAAGGGGGCGTCTCTGAGGACCGGGGTCTCTGGGGTGTTCCCCG
GAAACTACGTGACACCCGTTTCCAGGGTGCCTGCAGGAGGGGCAGGGCCGCCCCGGAATAATGTAGTCGGAGGGTCTCCACTGGCCAAAG
GGATAACCACAACCATGCACCCAGGCAGTGGGAGTCTGAGCAGCCTGGCCACTGCCACCAGGCCCGCCCTGCCCATCACCACTCCCCAGG
CCCACGCCCAGCACCCCACAGCCTCGCCCCCAACAGGCAGCTGTCTACGGCACTCAGCCCAGCCAACGGCCAGCCAAGCCCGGAGCACCA
TTTCAACAGCTGCCCACTCTGCAGCCCAGGCTCAGGACCGGCCAACTGCCACCGTGTCACCCCTGCGCACCCAGAACTCTCCATCCCGCC
TGCCTGCCACCAGCCTCAGGCCCCACTCGGTGGTGTCCCCGCAGCACAGCCACCAGCCCCCGGTGCAGATGTGCCCACGGCCGGCCATCC
CCCTCACATCAGCAGCATCAGCCATCACACCTCCCAACGTCAGTGCCGCAAACCTCAACGGGGAGGCTGGAGGGGGGCCCATCGGTGTTC
TGTCCACATCCAGCCCCACCAACACGGGATGCAAACTAGACGAGAAGAAAAGTGAAAAGAAAGAGAAGAAGAGTGGGCTCCTGAAGCTTC
TAGCCGGAGCATCCACCAAGAAGAAGTCACGCTCCCCGCCATCTGTGTCTCCAACCCACGACCCCCAGGTGGCCGTGGACGCCCTGCTCC
AAGGTGCAGTGGGCCCCGAAGTGTCCTCACTGTCCATCCACGGCAGGGCAGGGTCCTGCCCCATAGAGAGCGAGATGCAGGGTGCCATGG
GGATGGAGCCTCTGCACAGGAAGGCAGGCTCCTTGGATCTAAACTTCACATCTCCTTCCCGGCAAGCTCCGCTGTCCATGGCTGCCATCC
GCCCCGAGCCCAAGCTGTTGCCCAGAGAGAGGTACCGCGTGGTGGTCTCGTACCCACCCCAGAGTGAGGCGGAGATCGAGCTGAAGGAAG
GCGACATCGTCTTTGTGCACAAGAAGCGTGAGGACGGCTGGTACAAGGGGACCCTGCAGCGGAACGGCCGCACAGGCCTCTTCCCGGGCA

>80463_80463_6_SEPT10-SH3RF3_SEPT10_chr2_110310664_ENST00000545389_SH3RF3_chr2_110015046_ENST00000309415_length(amino acids)=792AA_BP=224
MPATMASSEVARHLLFQSHMATKTTCMSSQGSDDEQIVNIIPVIAKADTVSKTELQKFKIKLMSELVSNGVQIYQFPTDDDTIAKVNAAM
NGQLPFAVVGSMDEVKVGNKMVKARQYPWGVVQVENENHCDFVKLREMLICTNMEDLREQTHTRHYELYRRCKLEEMGFTDVGPENKPVS
VQETYEAKRHEFHGERQRKEEEMKQMFVQRVKEKEAILKEAERELNDSAKQLIEMDKPCPAAASSCNASLPSDSGAVASVAPSPTLSSSG
AVSAFQRRVDGKKNTKKRHSFTALSVTHRSSQAASHRHSMEISAPVLISSSDPRAAARIGDLAHLSCAAPTQDVSSSAGSTPTAVPRAAS
VSGEQGTPPKVQLPLNVYLALYAYKPQKSDELELHKGEMYRVLEKCQDGWFKGASLRTGVSGVFPGNYVTPVSRVPAGGAGPPRNNVVGG
SPLAKGITTTMHPGSGSLSSLATATRPALPITTPQAHAQHPTASPPTGSCLRHSAQPTASQARSTISTAAHSAAQAQDRPTATVSPLRTQ
NSPSRLPATSLRPHSVVSPQHSHQPPVQMCPRPAIPLTSAASAITPPNVSAANLNGEAGGGPIGVLSTSSPTNTGCKLDEKKSEKKEKKS
GLLKLLAGASTKKKSRSPPSVSPTHDPQVAVDALLQGAVGPEVSSLSIHGRAGSCPIESEMQGAMGMEPLHRKAGSLDLNFTSPSRQAPL

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Fusion Gene PPI Analysis for SEPT10-SH3RF3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Tgene	SH3RF3	chr2:110310664	chr2:110015046	ENST00000309415		2	10	369_439	315.0	883.0	RAC1

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SEPT10-SH3RF3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SEPT10-SH3RF3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source