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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SEPT7-VPS45 (FusionGDB2 ID:80503)

Fusion Gene Summary for SEPT7-VPS45

check button Fusion gene summary
Fusion gene informationFusion gene name: SEPT7-VPS45
Fusion gene ID: 80503
HgeneTgene
Gene symbol

SEPT7

VPS45

Gene ID

989

11311

Gene nameseptin 7vacuolar protein sorting 45 homolog
SynonymsCDC10|CDC3|NBLA02942|SEPT7|SEPT7AH1|H1VPS45|SCN5|VPS45A|VPS45B|VPS54A|VSP45|VSP45A
Cytomap

7p14.2

1q21.2

Type of geneprotein-codingprotein-coding
Descriptionseptin-7CDC10 (cell division cycle 10, S. cerevisiae, homolog)CDC10 protein homologseptin 7 variant 4vacuolar protein sorting-associated protein 45leucocyte vacuolar protein sorting 45vacuolar protein sorting 45A
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000475109, ENST00000350320, 
ENST00000399034, ENST00000399035, 
ENST00000435235, ENST00000469679, 
ENST00000494488, ENST00000432293, 
ENST00000369128, ENST00000369130, 
ENST00000484306, ENST00000535106, 
Fusion gene scores* DoF score8 X 5 X 7=2808 X 7 X 6=336
# samples 810
** MAII scorelog2(8/280*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/336*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEPT7 [Title/Abstract] AND VPS45 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSEPT7(35913385)-VPS45(150082610), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSEPT7

GO:0030336

negative regulation of cell migration

-

HgeneSEPT7

GO:0043065

positive regulation of apoptotic process

-

HgeneSEPT7

GO:2000134

negative regulation of G1/S transition of mitotic cell cycle

-


check buttonFusion gene breakpoints across SEPT7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across VPS45 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0H3SEPT7chr7

35913385

+VPS45chr1

150082610

+


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Fusion Gene ORF analysis for SEPT7-VPS45

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000475109ENST00000369128SEPT7chr7

35913385

+VPS45chr1

150082610

+
3UTR-3CDSENST00000475109ENST00000369130SEPT7chr7

35913385

+VPS45chr1

150082610

+
3UTR-3UTRENST00000475109ENST00000484306SEPT7chr7

35913385

+VPS45chr1

150082610

+
3UTR-3UTRENST00000475109ENST00000535106SEPT7chr7

35913385

+VPS45chr1

150082610

+
5CDS-3UTRENST00000350320ENST00000484306SEPT7chr7

35913385

+VPS45chr1

150082610

+
5CDS-3UTRENST00000350320ENST00000535106SEPT7chr7

35913385

+VPS45chr1

150082610

+
5CDS-3UTRENST00000399034ENST00000484306SEPT7chr7

35913385

+VPS45chr1

150082610

+
5CDS-3UTRENST00000399034ENST00000535106SEPT7chr7

35913385

+VPS45chr1

150082610

+
5CDS-3UTRENST00000399035ENST00000484306SEPT7chr7

35913385

+VPS45chr1

150082610

+
5CDS-3UTRENST00000399035ENST00000535106SEPT7chr7

35913385

+VPS45chr1

150082610

+
5CDS-3UTRENST00000435235ENST00000484306SEPT7chr7

35913385

+VPS45chr1

150082610

+
5CDS-3UTRENST00000435235ENST00000535106SEPT7chr7

35913385

+VPS45chr1

150082610

+
5CDS-3UTRENST00000469679ENST00000484306SEPT7chr7

35913385

+VPS45chr1

150082610

+
5CDS-3UTRENST00000469679ENST00000535106SEPT7chr7

35913385

+VPS45chr1

150082610

+
5CDS-3UTRENST00000494488ENST00000484306SEPT7chr7

35913385

+VPS45chr1

150082610

+
5CDS-3UTRENST00000494488ENST00000535106SEPT7chr7

35913385

+VPS45chr1

150082610

+
In-frameENST00000350320ENST00000369128SEPT7chr7

35913385

+VPS45chr1

150082610

+
In-frameENST00000350320ENST00000369130SEPT7chr7

35913385

+VPS45chr1

150082610

+
In-frameENST00000399034ENST00000369128SEPT7chr7

35913385

+VPS45chr1

150082610

+
In-frameENST00000399034ENST00000369130SEPT7chr7

35913385

+VPS45chr1

150082610

+
In-frameENST00000399035ENST00000369128SEPT7chr7

35913385

+VPS45chr1

150082610

+
In-frameENST00000399035ENST00000369130SEPT7chr7

35913385

+VPS45chr1

150082610

+
In-frameENST00000435235ENST00000369128SEPT7chr7

35913385

+VPS45chr1

150082610

+
In-frameENST00000435235ENST00000369130SEPT7chr7

35913385

+VPS45chr1

150082610

+
In-frameENST00000469679ENST00000369128SEPT7chr7

35913385

+VPS45chr1

150082610

+
In-frameENST00000469679ENST00000369130SEPT7chr7

35913385

+VPS45chr1

150082610

+
In-frameENST00000494488ENST00000369128SEPT7chr7

35913385

+VPS45chr1

150082610

+
In-frameENST00000494488ENST00000369130SEPT7chr7

35913385

+VPS45chr1

150082610

+
intron-3CDSENST00000432293ENST00000369128SEPT7chr7

35913385

+VPS45chr1

150082610

+
intron-3CDSENST00000432293ENST00000369130SEPT7chr7

35913385

+VPS45chr1

150082610

+
intron-3UTRENST00000432293ENST00000484306SEPT7chr7

35913385

+VPS45chr1

150082610

+
intron-3UTRENST00000432293ENST00000535106SEPT7chr7

35913385

+VPS45chr1

150082610

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000435235SEPT7chr735913385+ENST00000369130VPS45chr1150082610+1536785931004303
ENST00000435235SEPT7chr735913385+ENST00000369128VPS45chr1150082610+1591785931223376
ENST00000469679SEPT7chr735913385+ENST00000369130VPS45chr1150082610+1453702115921268
ENST00000469679SEPT7chr735913385+ENST00000369128VPS45chr1150082610+15087021151140341
ENST00000399034SEPT7chr735913385+ENST00000369130VPS45chr1150082610+1459708115927270
ENST00000399034SEPT7chr735913385+ENST00000369128VPS45chr1150082610+15147081151146343
ENST00000350320SEPT7chr735913385+ENST00000369130VPS45chr1150082610+1453702115921268
ENST00000350320SEPT7chr735913385+ENST00000369128VPS45chr1150082610+15087021151140341
ENST00000399035SEPT7chr735913385+ENST00000369130VPS45chr1150082610+12605090728242
ENST00000399035SEPT7chr735913385+ENST00000369128VPS45chr1150082610+13155090947315
ENST00000494488SEPT7chr735913385+ENST00000369130VPS45chr1150082610+1221470117689190
ENST00000494488SEPT7chr735913385+ENST00000369128VPS45chr1150082610+1276470117908263

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000435235ENST00000369130SEPT7chr735913385+VPS45chr1150082610+0.000979520.99902046
ENST00000435235ENST00000369128SEPT7chr735913385+VPS45chr1150082610+0.0132356760.9867643
ENST00000469679ENST00000369130SEPT7chr735913385+VPS45chr1150082610+0.0011389220.9988611
ENST00000469679ENST00000369128SEPT7chr735913385+VPS45chr1150082610+0.0021393820.9978606
ENST00000399034ENST00000369130SEPT7chr735913385+VPS45chr1150082610+0.0008324690.99916756
ENST00000399034ENST00000369128SEPT7chr735913385+VPS45chr1150082610+0.0029321320.99706787
ENST00000350320ENST00000369130SEPT7chr735913385+VPS45chr1150082610+0.0010921450.9989078
ENST00000350320ENST00000369128SEPT7chr735913385+VPS45chr1150082610+0.0020283940.9979716
ENST00000399035ENST00000369130SEPT7chr735913385+VPS45chr1150082610+0.0008696970.9991303
ENST00000399035ENST00000369128SEPT7chr735913385+VPS45chr1150082610+0.0015174420.9984825
ENST00000494488ENST00000369130SEPT7chr735913385+VPS45chr1150082610+0.0006107410.9993893
ENST00000494488ENST00000369128SEPT7chr735913385+VPS45chr1150082610+0.0078267830.9921732

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Fusion Genomic Features for SEPT7-VPS45


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SEPT7chr735913385+VPS45chr1150082610+8.85E-080.9999999
SEPT7chr735913385+VPS45chr1150082610+8.85E-080.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SEPT7-VPS45


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:35913385/chr1:150082610)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEPT7chr7:35913385chr1:150082610ENST00000399034+614113_116171439.0RegionG3 motif
HgeneSEPT7chr7:35913385chr1:150082610ENST00000399034+61457_64171439.0RegionG1 motif

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEPT7chr7:35913385chr1:150082610ENST00000399034+614332_437171439.0Coiled coilOntology_term=ECO:0000255
HgeneSEPT7chr7:35913385chr1:150082610ENST00000399034+61447_316171439.0DomainSeptin-type G
HgeneSEPT7chr7:35913385chr1:150082610ENST00000399034+614195_203171439.0Nucleotide bindingGTP
HgeneSEPT7chr7:35913385chr1:150082610ENST00000399034+614194_197171439.0RegionG4 motif


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Fusion Gene Sequence for SEPT7-VPS45


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>80503_80503_1_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000350320_VPS45_chr1_150082610_ENST00000369128_length(transcript)=1508nt_BP=702nt
AGCCTCGTCTGAGGGGGCGGGGGACGGAGGAGGGAGCGGGAGTCGAGCGAGAGCCTGTGGAGGAGTCCGCCTGCTGTAGCGTGCGTAAGC
AAGGCAGCTACGCCGGGCGGCTACGCTGCGGAATCGGCGTAGGCGCCTTTGGAGAATCGGCGGGCTGCGCTCCGCTGGGGCTGGTCGCGG
AGGGGGGGAGGGGATGTCGGTCAGTGCGAGATCCGCTGCTGCTGAGGAGAGGAGCGTCAACAGCAGCACCATGGGTCAACAGAAGAACCT
TGAAGGCTATGTGGGATTTGCCAATCTCCCAAATCAAGTATACAGAAAATCGGTGAAGAGAGGTTTTGAATTCACGCTTATGGTAGTGGG
TGAATCTGGATTGGGAAAGTCGACATTAATCAACTCATTATTCCTCACAGATTTGTATTCTCCAGAGTATCCAGGTCCTTCTCATAGAAT
TAAAAAGACTGTACAGGTGGAACAATCCAAAGTTTTAATCAAAGAAGGTGGTGTTCAGTTGCTGCTCACAATAGTTGATACCCCAGGATT
TGGAGATGCAGTGGATAATAGTAATTGCTGGCAGCCTGTTATCGACTACATTGATAGTAAATTTGAGGACTACCTAAATGCAGAATCACG
AGTGAACAGACGTCAGATGCCTGATAACAGGGTGCAGTGTTGTTTATACTTCATTGCTCCTTCAGGACATGGACCTCAGGATATCATTGT
GTTTGTAATTGGAGGAGCCACCTATGAAGAGGCTCTAACAGTTTATAACCTGAACCGCACCACTCCTGGAGTGAGGATTGTCCTGGGAGG
CACCACAGTGCACAACACGAAAAGAGATGGGGTTTCACTATGTTCCCCTGCCTGGTTTCGAACTCCTGGGCTCAAGCGATCCACCCGCCT
CAGCCTCCCAAAGTGCTGGGATTACAGCTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCA
CATCAAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAA
CAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACA
AGACTCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACT
TCAGTTACTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACAT
ACCACACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACC

>80503_80503_1_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000350320_VPS45_chr1_150082610_ENST00000369128_length(amino acids)=341AA_BP=196
MRNRRRRLWRIGGLRSAGAGRGGGEGMSVSARSAAAEERSVNSSTMGQQKNLEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKST
LINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPD
NRVQCCLYFIAPSGHGPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNTKRDGVSLCSPAWFRTPGLKRSTRLSLPKCWDY

--------------------------------------------------------------
>80503_80503_2_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000350320_VPS45_chr1_150082610_ENST00000369130_length(transcript)=1453nt_BP=702nt
AGCCTCGTCTGAGGGGGCGGGGGACGGAGGAGGGAGCGGGAGTCGAGCGAGAGCCTGTGGAGGAGTCCGCCTGCTGTAGCGTGCGTAAGC
AAGGCAGCTACGCCGGGCGGCTACGCTGCGGAATCGGCGTAGGCGCCTTTGGAGAATCGGCGGGCTGCGCTCCGCTGGGGCTGGTCGCGG
AGGGGGGGAGGGGATGTCGGTCAGTGCGAGATCCGCTGCTGCTGAGGAGAGGAGCGTCAACAGCAGCACCATGGGTCAACAGAAGAACCT
TGAAGGCTATGTGGGATTTGCCAATCTCCCAAATCAAGTATACAGAAAATCGGTGAAGAGAGGTTTTGAATTCACGCTTATGGTAGTGGG
TGAATCTGGATTGGGAAAGTCGACATTAATCAACTCATTATTCCTCACAGATTTGTATTCTCCAGAGTATCCAGGTCCTTCTCATAGAAT
TAAAAAGACTGTACAGGTGGAACAATCCAAAGTTTTAATCAAAGAAGGTGGTGTTCAGTTGCTGCTCACAATAGTTGATACCCCAGGATT
TGGAGATGCAGTGGATAATAGTAATTGCTGGCAGCCTGTTATCGACTACATTGATAGTAAATTTGAGGACTACCTAAATGCAGAATCACG
AGTGAACAGACGTCAGATGCCTGATAACAGGGTGCAGTGTTGTTTATACTTCATTGCTCCTTCAGGACATGGACCTCAGGATATCATTGT
GTTTGTAATTGGAGGAGCCACCTATGAAGAGGCTCTAACAGTTTATAACCTGAACCGCACCACTCCTGGAGTGAGGATTGTCCTGGGAGG
CACCACAGTGCACAACACGAAAAGTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATC
AAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAA
GGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGAC
TCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAG
TTACTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCA
CACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGT
TTCTTTACAGAGCCATCCAAAAATTTTTTGTCCCTACATAGCAATTTTCTGTGGCACTGAGAAACCATGTATGACCACAATAAAAATCCA

>80503_80503_2_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000350320_VPS45_chr1_150082610_ENST00000369130_length(amino acids)=268AA_BP=196
MRNRRRRLWRIGGLRSAGAGRGGGEGMSVSARSAAAEERSVNSSTMGQQKNLEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKST
LINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPD

--------------------------------------------------------------
>80503_80503_3_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000399034_VPS45_chr1_150082610_ENST00000369128_length(transcript)=1514nt_BP=708nt
AGCCTCGTCTGAGGGGGCGGGGGACGGAGGAGGGAGCGGGAGTCGAGCGAGAGCCTGTGGAGGAGTCCGCCTGCTGTAGCGTGCGTAAGC
AAGGCAGCTACGCCGGGCGGCTACGCTGCGGAATCGGCGTAGGCGCCTTTGGAGAATCGGCGGGCTGCGCTCCGCTGGGGCTGGTCGCGG
AGGGGGGGAGGGGATGTCGGTCAGTGCGAGATCCGCTGCTGCTGAGGAGAGGAGCGTCAACAGCAGCACCATGGAGGTTGCCCAACAGAA
GAACCTTGAAGGCTATGTGGGATTTGCCAATCTCCCAAATCAAGTATACAGAAAATCGGTGAAGAGAGGTTTTGAATTCACGCTTATGGT
AGTGGGTGAATCTGGATTGGGAAAGTCGACATTAATCAACTCATTATTCCTCACAGATTTGTATTCTCCAGAGTATCCAGGTCCTTCTCA
TAGAATTAAAAAGACTGTACAGGTGGAACAATCCAAAGTTTTAATCAAAGAAGGTGGTGTTCAGTTGCTGCTCACAATAGTTGATACCCC
AGGATTTGGAGATGCAGTGGATAATAGTAATTGCTGGCAGCCTGTTATCGACTACATTGATAGTAAATTTGAGGACTACCTAAATGCAGA
ATCACGAGTGAACAGACGTCAGATGCCTGATAACAGGGTGCAGTGTTGTTTATACTTCATTGCTCCTTCAGGACATGGACCTCAGGATAT
CATTGTGTTTGTAATTGGAGGAGCCACCTATGAAGAGGCTCTAACAGTTTATAACCTGAACCGCACCACTCCTGGAGTGAGGATTGTCCT
GGGAGGCACCACAGTGCACAACACGAAAAGAGATGGGGTTTCACTATGTTCCCCTGCCTGGTTTCGAACTCCTGGGCTCAAGCGATCCAC
CCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGCTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTC
AAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCT
ACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACA
GACACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACA
ATCACTTCAGTTACTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGAT
GTACATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAA

>80503_80503_3_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000399034_VPS45_chr1_150082610_ENST00000369128_length(amino acids)=343AA_BP=198
MRNRRRRLWRIGGLRSAGAGRGGGEGMSVSARSAAAEERSVNSSTMEVAQQKNLEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGK
STLINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQM
PDNRVQCCLYFIAPSGHGPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNTKRDGVSLCSPAWFRTPGLKRSTRLSLPKCW

--------------------------------------------------------------
>80503_80503_4_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000399034_VPS45_chr1_150082610_ENST00000369130_length(transcript)=1459nt_BP=708nt
AGCCTCGTCTGAGGGGGCGGGGGACGGAGGAGGGAGCGGGAGTCGAGCGAGAGCCTGTGGAGGAGTCCGCCTGCTGTAGCGTGCGTAAGC
AAGGCAGCTACGCCGGGCGGCTACGCTGCGGAATCGGCGTAGGCGCCTTTGGAGAATCGGCGGGCTGCGCTCCGCTGGGGCTGGTCGCGG
AGGGGGGGAGGGGATGTCGGTCAGTGCGAGATCCGCTGCTGCTGAGGAGAGGAGCGTCAACAGCAGCACCATGGAGGTTGCCCAACAGAA
GAACCTTGAAGGCTATGTGGGATTTGCCAATCTCCCAAATCAAGTATACAGAAAATCGGTGAAGAGAGGTTTTGAATTCACGCTTATGGT
AGTGGGTGAATCTGGATTGGGAAAGTCGACATTAATCAACTCATTATTCCTCACAGATTTGTATTCTCCAGAGTATCCAGGTCCTTCTCA
TAGAATTAAAAAGACTGTACAGGTGGAACAATCCAAAGTTTTAATCAAAGAAGGTGGTGTTCAGTTGCTGCTCACAATAGTTGATACCCC
AGGATTTGGAGATGCAGTGGATAATAGTAATTGCTGGCAGCCTGTTATCGACTACATTGATAGTAAATTTGAGGACTACCTAAATGCAGA
ATCACGAGTGAACAGACGTCAGATGCCTGATAACAGGGTGCAGTGTTGTTTATACTTCATTGCTCCTTCAGGACATGGACCTCAGGATAT
CATTGTGTTTGTAATTGGAGGAGCCACCTATGAAGAGGCTCTAACAGTTTATAACCTGAACCGCACCACTCCTGGAGTGAGGATTGTCCT
GGGAGGCACCACAGTGCACAACACGAAAAGTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGT
CACATCAAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTA
AACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACA
CAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCA
CTTCAGTTACTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTAC
ATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTA
CCATGTTTCTTTACAGAGCCATCCAAAAATTTTTTGTCCCTACATAGCAATTTTCTGTGGCACTGAGAAACCATGTATGACCACAATAAA

>80503_80503_4_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000399034_VPS45_chr1_150082610_ENST00000369130_length(amino acids)=270AA_BP=198
MRNRRRRLWRIGGLRSAGAGRGGGEGMSVSARSAAAEERSVNSSTMEVAQQKNLEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGK
STLINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQM
PDNRVQCCLYFIAPSGHGPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNTKSFLEEVLASGLHSRSKESSQVTSRSASRR

--------------------------------------------------------------
>80503_80503_5_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000399035_VPS45_chr1_150082610_ENST00000369128_length(transcript)=1315nt_BP=509nt
ATGTCGGTCAGTGCGAGATCCGCTGCTGCTGAGGAGAGGAGCGTCAACAGCAGCACCATGGTACAACAGAAGAACCTTGAAGGCTATGTG
GGATTTGCCAATCTCCCAAATCAAGTATACAGAAAATCGGTGAAGAGAGGTTTTGAATTCACGCTTATGGTAGTGGGTGAATCTGGATTG
GGAAAGTCGACATTAATCAACTCATTATTCCTCACAGATTTGTATTCTCCAGAGTATCCAGGTCCTTCTCATAGAATTAAAAAGACTGTA
CAGGTGGAACAATCCAAAGTTTTAATCAAAGAAGGTGGTGTTCAGTTGCTGCTCACAATAGTTGATACCCCAGGATTTGGAGATGCAGTG
GATAATAGTAATTGCTGGCAGCCTGTTATCGACTACATTGATAGTAAATTTGAGGACTACCTAAATGCAGAATCACGAGTGAACAGACGT
CAGATGCCTGATAACAGGGTGCAGTGTTGTTTATACTTCATTGCTCCTTCAGGACATGGACCTCAGGATATCATTGTGTTTGTAATTGGA
GGAGCCACCTATGAAGAGGCTCTAACAGTTTATAACCTGAACCGCACCACTCCTGGAGTGAGGATTGTCCTGGGAGGCACCACAGTGCAC
AACACGAAAAGAGATGGGGTTTCACTATGTTCCCCTGCCTGGTTTCGAACTCCTGGGCTCAAGCGATCCACCCGCCTCAGCCTCCCAAAG
TGCTGGGATTACAGCTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGC
GAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGA
GAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGT
TGTCCTAACAATAAGTCTGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATG
AATTTTGTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTG
GCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACA

>80503_80503_5_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000399035_VPS45_chr1_150082610_ENST00000369128_length(amino acids)=315AA_BP=170
MSVSARSAAAEERSVNSSTMVQQKNLEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSPEYPGPSHRIKKTV
QVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPDNRVQCCLYFIAPSGHGPQDIIVFVIG
GATYEEALTVYNLNRTTPGVRIVLGGTTVHNTKRDGVSLCSPAWFRTPGLKRSTRLSLPKCWDYSFPRGSSGFWTAQPKQGELSSHIKVS

--------------------------------------------------------------
>80503_80503_6_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000399035_VPS45_chr1_150082610_ENST00000369130_length(transcript)=1260nt_BP=509nt
ATGTCGGTCAGTGCGAGATCCGCTGCTGCTGAGGAGAGGAGCGTCAACAGCAGCACCATGGTACAACAGAAGAACCTTGAAGGCTATGTG
GGATTTGCCAATCTCCCAAATCAAGTATACAGAAAATCGGTGAAGAGAGGTTTTGAATTCACGCTTATGGTAGTGGGTGAATCTGGATTG
GGAAAGTCGACATTAATCAACTCATTATTCCTCACAGATTTGTATTCTCCAGAGTATCCAGGTCCTTCTCATAGAATTAAAAAGACTGTA
CAGGTGGAACAATCCAAAGTTTTAATCAAAGAAGGTGGTGTTCAGTTGCTGCTCACAATAGTTGATACCCCAGGATTTGGAGATGCAGTG
GATAATAGTAATTGCTGGCAGCCTGTTATCGACTACATTGATAGTAAATTTGAGGACTACCTAAATGCAGAATCACGAGTGAACAGACGT
CAGATGCCTGATAACAGGGTGCAGTGTTGTTTATACTTCATTGCTCCTTCAGGACATGGACCTCAGGATATCATTGTGTTTGTAATTGGA
GGAGCCACCTATGAAGAGGCTCTAACAGTTTATAACCTGAACCGCACCACTCCTGGAGTGAGGATTGTCCTGGGAGGCACCACAGTGCAC
AACACGAAAAGTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGC
AGAAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGC
AGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTC
CTAACAATAAGTCTGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATT
TTGTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTT
CCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGC
CATCCAAAAATTTTTTGTCCCTACATAGCAATTTTCTGTGGCACTGAGAAACCATGTATGACCACAATAAAAATCCATTTTGTGAAAGGA

>80503_80503_6_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000399035_VPS45_chr1_150082610_ENST00000369130_length(amino acids)=242AA_BP=170
MSVSARSAAAEERSVNSSTMVQQKNLEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSPEYPGPSHRIKKTV
QVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPDNRVQCCLYFIAPSGHGPQDIIVFVIG

--------------------------------------------------------------
>80503_80503_7_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000435235_VPS45_chr1_150082610_ENST00000369128_length(transcript)=1591nt_BP=785nt
AAGTCATGCTCGAAATGGAGCGAGGCGGCGGAGCTGGGGAGGCGGTAATCTCGCGAGATGGAAGCCAGCCTCCGCTAGGCCCGGAAGCCT
CGTCTGAGGGGGCGGGGGACGGAGGAGGGAGCGGGAGTCGAGCGAGAGCCTGTGGAGGAGTCCGCCTGCTGTAGCGTGCGTAAGCAAGGC
AGCTACGCCGGGCGGCTACGCTGCGGAATCGGCGTAGGCGCCTTTGGAGAATCGGCGGGCTGCGCTCCGCTGGGGCTGGTCGCGGAGGGG
GGGAGGGGATGTCGGTCAGTGCGAGATCCGCTGCTGCTGAGGAGAGGAGCGTCAACAGCAGCACCATGGCAACAGAAGAACCTTGAAGGC
TATGTGGGATTTGCCAATCTCCCAAATCAAGTATACAGAAAATCGGTGAAGAGAGGTTTTGAATTCACGCTTATGGTAGTGGGTGAATCT
GGATTGGGAAAGTCGACATTAATCAACTCATTATTCCTCACAGATTTGTATTCTCCAGAGTATCCAGGTCCTTCTCATAGAATTAAAAAG
ACTGTACAGGTGGAACAATCCAAAGTTTTAATCAAAGAAGGTGGTGTTCAGTTGCTGCTCACAATAGTTGATACCCCAGGATTTGGAGAT
GCAGTGGATAATAGTAATTGCTGGCAGCCTGTTATCGACTACATTGATAGTAAATTTGAGGACTACCTAAATGCAGAATCACGAGTGAAC
AGACGTCAGATGCCTGATAACAGGGTGCAGTGTTGTTTATACTTCATTGCTCCTTCAGGACATGGACCTCAGGATATCATTGTGTTTGTA
ATTGGAGGAGCCACCTATGAAGAGGCTCTAACAGTTTATAACCTGAACCGCACCACTCCTGGAGTGAGGATTGTCCTGGGAGGCACCACA
GTGCACAACACGAAAAGAGATGGGGTTTCACTATGTTCCCCTGCCTGGTTTCGAACTCCTGGGCTCAAGCGATCCACCCGCCTCAGCCTC
CCAAAGTGCTGGGATTACAGCTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAG
GTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGT
GTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCC
CAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTA
CTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACAC
TCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTC

>80503_80503_7_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000435235_VPS45_chr1_150082610_ENST00000369128_length(amino acids)=376AA_BP=231
MRGRGTEEGAGVEREPVEESACCSVRKQGSYAGRLRCGIGVGAFGESAGCAPLGLVAEGGRGCRSVRDPLLLRRGASTAAPWQQKNLEGY
VGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDA
VDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPDNRVQCCLYFIAPSGHGPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTV
HNTKRDGVSLCSPAWFRTPGLKRSTRLSLPKCWDYSFPRGSSGFWTAQPKQGELSSHIKVSEQKMKRWLGEGHSFLSCPHYRFSLLNKGV

--------------------------------------------------------------
>80503_80503_8_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000435235_VPS45_chr1_150082610_ENST00000369130_length(transcript)=1536nt_BP=785nt
AAGTCATGCTCGAAATGGAGCGAGGCGGCGGAGCTGGGGAGGCGGTAATCTCGCGAGATGGAAGCCAGCCTCCGCTAGGCCCGGAAGCCT
CGTCTGAGGGGGCGGGGGACGGAGGAGGGAGCGGGAGTCGAGCGAGAGCCTGTGGAGGAGTCCGCCTGCTGTAGCGTGCGTAAGCAAGGC
AGCTACGCCGGGCGGCTACGCTGCGGAATCGGCGTAGGCGCCTTTGGAGAATCGGCGGGCTGCGCTCCGCTGGGGCTGGTCGCGGAGGGG
GGGAGGGGATGTCGGTCAGTGCGAGATCCGCTGCTGCTGAGGAGAGGAGCGTCAACAGCAGCACCATGGCAACAGAAGAACCTTGAAGGC
TATGTGGGATTTGCCAATCTCCCAAATCAAGTATACAGAAAATCGGTGAAGAGAGGTTTTGAATTCACGCTTATGGTAGTGGGTGAATCT
GGATTGGGAAAGTCGACATTAATCAACTCATTATTCCTCACAGATTTGTATTCTCCAGAGTATCCAGGTCCTTCTCATAGAATTAAAAAG
ACTGTACAGGTGGAACAATCCAAAGTTTTAATCAAAGAAGGTGGTGTTCAGTTGCTGCTCACAATAGTTGATACCCCAGGATTTGGAGAT
GCAGTGGATAATAGTAATTGCTGGCAGCCTGTTATCGACTACATTGATAGTAAATTTGAGGACTACCTAAATGCAGAATCACGAGTGAAC
AGACGTCAGATGCCTGATAACAGGGTGCAGTGTTGTTTATACTTCATTGCTCCTTCAGGACATGGACCTCAGGATATCATTGTGTTTGTA
ATTGGAGGAGCCACCTATGAAGAGGCTCTAACAGTTTATAACCTGAACCGCACCACTCCTGGAGTGAGGATTGTCCTGGGAGGCACCACA
GTGCACAACACGAAAAGTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCA
GCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTG
GAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGA
GTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGA
TGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCT
TGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTA
CAGAGCCATCCAAAAATTTTTTGTCCCTACATAGCAATTTTCTGTGGCACTGAGAAACCATGTATGACCACAATAAAAATCCATTTTGTG

>80503_80503_8_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000435235_VPS45_chr1_150082610_ENST00000369130_length(amino acids)=303AA_BP=231
MRGRGTEEGAGVEREPVEESACCSVRKQGSYAGRLRCGIGVGAFGESAGCAPLGLVAEGGRGCRSVRDPLLLRRGASTAAPWQQKNLEGY
VGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKSTLINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDA
VDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPDNRVQCCLYFIAPSGHGPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTV

--------------------------------------------------------------
>80503_80503_9_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000469679_VPS45_chr1_150082610_ENST00000369128_length(transcript)=1508nt_BP=702nt
AGCCTCGTCTGAGGGGGCGGGGGACGGAGGAGGGAGCGGGAGTCGAGCGAGAGCCTGTGGAGGAGTCCGCCTGCTGTAGCGTGCGTAAGC
AAGGCAGCTACGCCGGGCGGCTACGCTGCGGAATCGGCGTAGGCGCCTTTGGAGAATCGGCGGGCTGCGCTCCGCTGGGGCTGGTCGCGG
AGGGGGGGAGGGGATGTCGGTCAGTGCGAGATCCGCTGCTGCTGAGGAGAGGAGCGTCAACAGCAGCACCATGGGGCAACAGAAGAACCT
TGAAGGCTATGTGGGATTTGCCAATCTCCCAAATCAAGTATACAGAAAATCGGTGAAGAGAGGTTTTGAATTCACGCTTATGGTAGTGGG
TGAATCTGGATTGGGAAAGTCGACATTAATCAACTCATTATTCCTCACAGATTTGTATTCTCCAGAGTATCCAGGTCCTTCTCATAGAAT
TAAAAAGACTGTACAGGTGGAACAATCCAAAGTTTTAATCAAAGAAGGTGGTGTTCAGTTGCTGCTCACAATAGTTGATACCCCAGGATT
TGGAGATGCAGTGGATAATAGTAATTGCTGGCAGCCTGTTATCGACTACATTGATAGTAAATTTGAGGACTACCTAAATGCAGAATCACG
AGTGAACAGACGTCAGATGCCTGATAACAGGGTGCAGTGTTGTTTATACTTCATTGCTCCTTCAGGACATGGACCTCAGGATATCATTGT
GTTTGTAATTGGAGGAGCCACCTATGAAGAGGCTCTAACAGTTTATAACCTGAACCGCACCACTCCTGGAGTGAGGATTGTCCTGGGAGG
CACCACAGTGCACAACACGAAAAGAGATGGGGTTTCACTATGTTCCCCTGCCTGGTTTCGAACTCCTGGGCTCAAGCGATCCACCCGCCT
CAGCCTCCCAAAGTGCTGGGATTACAGCTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCA
CATCAAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAA
CAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACA
AGACTCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACT
TCAGTTACTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACAT
ACCACACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACC

>80503_80503_9_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000469679_VPS45_chr1_150082610_ENST00000369128_length(amino acids)=341AA_BP=196
MRNRRRRLWRIGGLRSAGAGRGGGEGMSVSARSAAAEERSVNSSTMGQQKNLEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKST
LINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPD
NRVQCCLYFIAPSGHGPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNTKRDGVSLCSPAWFRTPGLKRSTRLSLPKCWDY

--------------------------------------------------------------
>80503_80503_10_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000469679_VPS45_chr1_150082610_ENST00000369130_length(transcript)=1453nt_BP=702nt
AGCCTCGTCTGAGGGGGCGGGGGACGGAGGAGGGAGCGGGAGTCGAGCGAGAGCCTGTGGAGGAGTCCGCCTGCTGTAGCGTGCGTAAGC
AAGGCAGCTACGCCGGGCGGCTACGCTGCGGAATCGGCGTAGGCGCCTTTGGAGAATCGGCGGGCTGCGCTCCGCTGGGGCTGGTCGCGG
AGGGGGGGAGGGGATGTCGGTCAGTGCGAGATCCGCTGCTGCTGAGGAGAGGAGCGTCAACAGCAGCACCATGGGGCAACAGAAGAACCT
TGAAGGCTATGTGGGATTTGCCAATCTCCCAAATCAAGTATACAGAAAATCGGTGAAGAGAGGTTTTGAATTCACGCTTATGGTAGTGGG
TGAATCTGGATTGGGAAAGTCGACATTAATCAACTCATTATTCCTCACAGATTTGTATTCTCCAGAGTATCCAGGTCCTTCTCATAGAAT
TAAAAAGACTGTACAGGTGGAACAATCCAAAGTTTTAATCAAAGAAGGTGGTGTTCAGTTGCTGCTCACAATAGTTGATACCCCAGGATT
TGGAGATGCAGTGGATAATAGTAATTGCTGGCAGCCTGTTATCGACTACATTGATAGTAAATTTGAGGACTACCTAAATGCAGAATCACG
AGTGAACAGACGTCAGATGCCTGATAACAGGGTGCAGTGTTGTTTATACTTCATTGCTCCTTCAGGACATGGACCTCAGGATATCATTGT
GTTTGTAATTGGAGGAGCCACCTATGAAGAGGCTCTAACAGTTTATAACCTGAACCGCACCACTCCTGGAGTGAGGATTGTCCTGGGAGG
CACCACAGTGCACAACACGAAAAGTTTCCTAGAGGAAGTTCTGGCTTCTGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATC
AAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAA
GGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGAC
TCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCACTTTTCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAG
TTACTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCA
CACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGT
TTCTTTACAGAGCCATCCAAAAATTTTTTGTCCCTACATAGCAATTTTCTGTGGCACTGAGAAACCATGTATGACCACAATAAAAATCCA

>80503_80503_10_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000469679_VPS45_chr1_150082610_ENST00000369130_length(amino acids)=268AA_BP=196
MRNRRRRLWRIGGLRSAGAGRGGGEGMSVSARSAAAEERSVNSSTMGQQKNLEGYVGFANLPNQVYRKSVKRGFEFTLMVVGESGLGKST
LINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLNAESRVNRRQMPD

--------------------------------------------------------------
>80503_80503_11_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000494488_VPS45_chr1_150082610_ENST00000369128_length(transcript)=1276nt_BP=470nt
GTTACTCACGAAACTATTGTTGAGCAACAGAAGAACCTTGAAGGCTATGTGGGATTTGCCAATCTCCCAAATCAAGTATACAGAAAATCG
GTGAAGAGAGGTTTTGAATTCACGCTTATGGTAGTGGGTGAATCTGGATTGGGAAAGTCGACATTAATCAACTCATTATTCCTCACAGAT
TTGTATTCTCCAGAGTATCCAGGTCCTTCTCATAGAATTAAAAAGACTGTACAGGTGGAACAATCCAAAGTTTTAATCAAAGAAGGTGGT
GTTCAGTTGCTGCTCACAATAGTTGATACCCCAGGATTTGGAGATGCAGTGGATAATAGTAATTGCTGGCAGCCTGTTATCGACTACATT
GATAGTAAATTTGAGGACTACCTAAATGCAGAATCACGAGTGAACAGACGTCAGATGCCTGATAACAGGGTGCAGTGTTGTTTATACTTC
ATTGCTCCTTCAGGACATGGACCTCAGGATATCATTGTGTTTGTAATTGGAGGAGCCACCTATGAAGAGGCTCTAACAGTTTATAACCTG
AACCGCACCACTCCTGGAGTGAGGATTGTCCTGGGAGGCACCACAGTGCACAACACGAAAAGAGATGGGGTTTCACTATGTTCCCCTGCC
TGGTTTCGAACTCCTGGGCTCAAGCGATCCACCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGCTTTCCTAGAGGAAGTTCTGGCTTC
TGGACTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCACAGC
TTCCTCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCATC
TCCAGGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCACTTT
TCTCCGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTATCAGA
GCCTAGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCATT
AACCACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTTTTTGTCCCTACATAGCAATTTT

>80503_80503_11_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000494488_VPS45_chr1_150082610_ENST00000369128_length(amino acids)=263AA_BP=118
MVVGESGLGKSTLINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLN
AESRVNRRQMPDNRVQCCLYFIAPSGHGPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNTKRDGVSLCSPAWFRTPGLKR

--------------------------------------------------------------
>80503_80503_12_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000494488_VPS45_chr1_150082610_ENST00000369130_length(transcript)=1221nt_BP=470nt
GTTACTCACGAAACTATTGTTGAGCAACAGAAGAACCTTGAAGGCTATGTGGGATTTGCCAATCTCCCAAATCAAGTATACAGAAAATCG
GTGAAGAGAGGTTTTGAATTCACGCTTATGGTAGTGGGTGAATCTGGATTGGGAAAGTCGACATTAATCAACTCATTATTCCTCACAGAT
TTGTATTCTCCAGAGTATCCAGGTCCTTCTCATAGAATTAAAAAGACTGTACAGGTGGAACAATCCAAAGTTTTAATCAAAGAAGGTGGT
GTTCAGTTGCTGCTCACAATAGTTGATACCCCAGGATTTGGAGATGCAGTGGATAATAGTAATTGCTGGCAGCCTGTTATCGACTACATT
GATAGTAAATTTGAGGACTACCTAAATGCAGAATCACGAGTGAACAGACGTCAGATGCCTGATAACAGGGTGCAGTGTTGTTTATACTTC
ATTGCTCCTTCAGGACATGGACCTCAGGATATCATTGTGTTTGTAATTGGAGGAGCCACCTATGAAGAGGCTCTAACAGTTTATAACCTG
AACCGCACCACTCCTGGAGTGAGGATTGTCCTGGGAGGCACCACAGTGCACAACACGAAAAGTTTCCTAGAGGAAGTTCTGGCTTCTGGA
CTGCACAGCCGAAGCAAGGAGAGCTCTCAAGTCACATCAAGGTCAGCGAGCAGAAGATGAAACGGTGGTTGGGGGAAGGGCACAGCTTCC
TCTCTTGTCCCCACTACAGGTTTTCCCTACTAAACAAAGGTGTTGGAGAGCAGCTTTGGGTTCTGTGCTGGTTGTTAGAACTCATCTCCA
GGTAGCCCACGGATACGTGGTTGGCACAGACACAAGACTCCCAGAGTTGTCCTAACAATAAGTCTGAGCCCATCTCAACCCACTTTTCTC
CGGTAGTCTTTATGTATCTGTTAGCACAATCACTTCAGTTACTGATGAATTTTGTTGGGATCTGACTTGGGGAAAGGGTTATCAGAGCCT
AGAGGGGCTTAAAAAGTAATCATTTGATGTACATACCACACTCCTTGGCTTCCTTTCTCTTCCCTTAACCCTTTCTGCTTTTCATTAACC
ACATTCCTGCACAACTCATTTCTGAAAACCTACCATGTTTCTTTACAGAGCCATCCAAAAATTTTTTGTCCCTACATAGCAATTTTCTGT

>80503_80503_12_SEPT7-VPS45_SEPT7_chr7_35913385_ENST00000494488_VPS45_chr1_150082610_ENST00000369130_length(amino acids)=190AA_BP=118
MVVGESGLGKSTLINSLFLTDLYSPEYPGPSHRIKKTVQVEQSKVLIKEGGVQLLLTIVDTPGFGDAVDNSNCWQPVIDYIDSKFEDYLN
AESRVNRRQMPDNRVQCCLYFIAPSGHGPQDIIVFVIGGATYEEALTVYNLNRTTPGVRIVLGGTTVHNTKSFLEEVLASGLHSRSKESS

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Fusion Gene PPI Analysis for SEPT7-VPS45


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSEPT7chr7:35913385chr1:150082610ENST00000399034+61447_317171.66666666666666439.0SEPTIN12


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SEPT7-VPS45


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SEPT7-VPS45


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource