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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SEPT9-MPO (FusionGDB2 ID:80525)

Fusion Gene Summary for SEPT9-MPO

check button Fusion gene summary
Fusion gene informationFusion gene name: SEPT9-MPO
Fusion gene ID: 80525
HgeneTgene
Gene symbol

SEPT9

MPO

Gene ID

10801

4353

Gene nameseptin 9myeloperoxidase
SynonymsAF17q25|MSF|MSF1|NAPB|PNUTL4|SEPT9|SINT1|SeptD1-
Cytomap

17q25.3

17q22

Type of geneprotein-codingprotein-coding
Descriptionseptin-9MLL septin-like fusion protein MSF-AOv/Br septinovarian/breast septinseptin D1myeloperoxidase
Modification date2020032820200329
UniProtAcc.

P05164

Ensembl transtripts involved in fusion geneENST00000427177, ENST00000431235, 
ENST00000449803, ENST00000329047, 
ENST00000423034, ENST00000427180, 
ENST00000427674, ENST00000541152, 
ENST00000585930, ENST00000588690, 
ENST00000590294, ENST00000590917, 
ENST00000591088, ENST00000591198, 
ENST00000592420, ENST00000592481, 
ENST00000592951, 		ENST00000578493, 
ENST00000225275, ENST00000340482, 
Fusion gene scores* DoF score31 X 14 X 18=781212 X 18 X 3=648
# samples 4112
** MAII scorelog2(41/7812*10)=-4.25199613438135
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/648*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEPT9 [Title/Abstract] AND MPO [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSEPT9(75303279)-MPO(56351030), # samples:1
SEPT9(75303279)-MPO(56353063), # samples:1
Anticipated loss of major functional domain due to fusion event.SEPT9-MPO seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMPO

GO:0034374

low-density lipoprotein particle remodeling

10772654

TgeneMPO

GO:0042744

hydrogen peroxide catabolic process

10772654|11907569

TgeneMPO

GO:0055114

oxidation-reduction process

10772654


check buttonFusion gene breakpoints across SEPT9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MPO (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-05-5429-01ASEPT9chr17

75303279

+MPOchr17

56351030

-
ChimerDB4LUADTCGA-05-5429-01ASEPT9chr17

75303279

-MPOchr17

56353063

-


Top

Fusion Gene ORF analysis for SEPT9-MPO

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000427177ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
5CDS-intronENST00000427177ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-
5UTR-3CDSENST00000431235ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
5UTR-3CDSENST00000431235ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
5UTR-3CDSENST00000431235ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
5UTR-3CDSENST00000431235ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
5UTR-3CDSENST00000449803ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
5UTR-3CDSENST00000449803ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
5UTR-3CDSENST00000449803ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
5UTR-3CDSENST00000449803ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
5UTR-5UTRENST00000431235ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
5UTR-5UTRENST00000449803ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
5UTR-intronENST00000431235ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-
5UTR-intronENST00000449803ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-
Frame-shiftENST00000427177ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
Frame-shiftENST00000427177ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
In-frameENST00000427177ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
In-frameENST00000427177ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000329047ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000329047ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000329047ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000329047ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000423034ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000423034ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000423034ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000423034ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000427180ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000427180ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000427180ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000427180ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000427674ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000427674ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000427674ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000427674ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000541152ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000541152ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000541152ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000541152ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000585930ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000585930ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000585930ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000585930ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000588690ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000588690ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000588690ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000588690ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000590294ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000590294ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000590294ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000590294ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000590917ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000590917ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000590917ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000590917ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000591088ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000591088ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000591088ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000591088ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000591198ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000591198ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000591198ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000591198ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000592420ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000592420ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000592420ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000592420ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000592481ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000592481ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000592481ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000592481ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000592951ENST00000225275SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000592951ENST00000225275SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-3CDSENST00000592951ENST00000340482SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-3CDSENST00000592951ENST00000340482SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-5UTRENST00000329047ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-5UTRENST00000423034ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-5UTRENST00000427180ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-5UTRENST00000427674ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-5UTRENST00000541152ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-5UTRENST00000585930ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-5UTRENST00000588690ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-5UTRENST00000590294ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-5UTRENST00000590917ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-5UTRENST00000591088ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-5UTRENST00000591198ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-5UTRENST00000592420ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-5UTRENST00000592481ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-5UTRENST00000592951ENST00000578493SEPT9chr17

75303279

-MPOchr17

56353063

-
intron-intronENST00000329047ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-intronENST00000423034ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-intronENST00000427180ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-intronENST00000427674ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-intronENST00000541152ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-intronENST00000585930ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-intronENST00000588690ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-intronENST00000590294ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-intronENST00000590917ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-intronENST00000591088ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-intronENST00000591198ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-intronENST00000592420ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-intronENST00000592481ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-
intron-intronENST00000592951ENST00000578493SEPT9chr17

75303279

+MPOchr17

56351030

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000427177SEPT9chr1775303279-ENST00000340482MPOchr1756353063-20362021261235369
ENST00000427177SEPT9chr1775303279-ENST00000225275MPOchr1756353063-20362021261235369

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000427177ENST00000340482SEPT9chr1775303279-MPOchr1756353063-0.0126343680.9873656
ENST00000427177ENST00000225275SEPT9chr1775303279-MPOchr1756353063-0.0126343680.9873656

Top

Fusion Genomic Features for SEPT9-MPO


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SEPT9-MPO


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:75303279/chr17:56351030)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MPO

P05164

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity. {ECO:0000269|PubMed:9922160}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSEPT9chr17:75303279chr17:56353063ENST00000329047-111295_5670569.0DomainSeptin-type G
HgeneSEPT9chr17:75303279chr17:56353063ENST00000423034-111295_5670580.0DomainSeptin-type G
HgeneSEPT9chr17:75303279chr17:56353063ENST00000427177-212295_56725587.0DomainSeptin-type G
HgeneSEPT9chr17:75303279chr17:56353063ENST00000427180-110295_5670475.0DomainSeptin-type G
HgeneSEPT9chr17:75303279chr17:56353063ENST00000427674-111295_5670423.0DomainSeptin-type G
HgeneSEPT9chr17:75303279chr17:56353063ENST00000431235-212295_5670423.0DomainSeptin-type G
HgeneSEPT9chr17:75303279chr17:56353063ENST00000449803-212295_5670423.0DomainSeptin-type G
HgeneSEPT9chr17:75303279chr17:56353063ENST00000541152-110295_5670336.0DomainSeptin-type G
HgeneSEPT9chr17:75303279chr17:56353063ENST00000585930-110295_5670363.0DomainSeptin-type G
HgeneSEPT9chr17:75303279chr17:56353063ENST00000588690-112295_5670512.6666666666666DomainSeptin-type G
HgeneSEPT9chr17:75303279chr17:56353063ENST00000590294-112295_5670354.3333333333333DomainSeptin-type G
HgeneSEPT9chr17:75303279chr17:56353063ENST00000591088-110295_5670336.0DomainSeptin-type G
HgeneSEPT9chr17:75303279chr17:56353063ENST00000591198-111295_5670568.0DomainSeptin-type G
HgeneSEPT9chr17:75303279chr17:56353063ENST00000592951-110295_5670336.0DomainSeptin-type G
HgeneSEPT9chr17:75303279chr17:56353063ENST00000329047-111445_4530569.0Nucleotide bindingGTP
HgeneSEPT9chr17:75303279chr17:56353063ENST00000423034-111445_4530580.0Nucleotide bindingGTP
HgeneSEPT9chr17:75303279chr17:56353063ENST00000427177-212445_45325587.0Nucleotide bindingGTP
HgeneSEPT9chr17:75303279chr17:56353063ENST00000427180-110445_4530475.0Nucleotide bindingGTP
HgeneSEPT9chr17:75303279chr17:56353063ENST00000427674-111445_4530423.0Nucleotide bindingGTP
HgeneSEPT9chr17:75303279chr17:56353063ENST00000431235-212445_4530423.0Nucleotide bindingGTP
HgeneSEPT9chr17:75303279chr17:56353063ENST00000449803-212445_4530423.0Nucleotide bindingGTP
HgeneSEPT9chr17:75303279chr17:56353063ENST00000541152-110445_4530336.0Nucleotide bindingGTP
HgeneSEPT9chr17:75303279chr17:56353063ENST00000585930-110445_4530363.0Nucleotide bindingGTP
HgeneSEPT9chr17:75303279chr17:56353063ENST00000588690-112445_4530512.6666666666666Nucleotide bindingGTP
HgeneSEPT9chr17:75303279chr17:56353063ENST00000590294-112445_4530354.3333333333333Nucleotide bindingGTP
HgeneSEPT9chr17:75303279chr17:56353063ENST00000591088-110445_4530336.0Nucleotide bindingGTP
HgeneSEPT9chr17:75303279chr17:56353063ENST00000591198-111445_4530568.0Nucleotide bindingGTP
HgeneSEPT9chr17:75303279chr17:56353063ENST00000592951-110445_4530336.0Nucleotide bindingGTP
HgeneSEPT9chr17:75303279chr17:56353063ENST00000329047-111305_3120569.0RegionG1 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000329047-111362_3650569.0RegionG3 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000329047-111444_4470569.0RegionG4 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000423034-111305_3120580.0RegionG1 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000423034-111362_3650580.0RegionG3 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000423034-111444_4470580.0RegionG4 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000427177-212305_31225587.0RegionG1 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000427177-212362_36525587.0RegionG3 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000427177-212444_44725587.0RegionG4 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000427180-110305_3120475.0RegionG1 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000427180-110362_3650475.0RegionG3 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000427180-110444_4470475.0RegionG4 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000427674-111305_3120423.0RegionG1 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000427674-111362_3650423.0RegionG3 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000427674-111444_4470423.0RegionG4 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000431235-212305_3120423.0RegionG1 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000431235-212362_3650423.0RegionG3 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000431235-212444_4470423.0RegionG4 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000449803-212305_3120423.0RegionG1 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000449803-212362_3650423.0RegionG3 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000449803-212444_4470423.0RegionG4 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000541152-110305_3120336.0RegionG1 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000541152-110362_3650336.0RegionG3 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000541152-110444_4470336.0RegionG4 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000585930-110305_3120363.0RegionG1 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000585930-110362_3650363.0RegionG3 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000585930-110444_4470363.0RegionG4 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000588690-112305_3120512.6666666666666RegionG1 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000588690-112362_3650512.6666666666666RegionG3 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000588690-112444_4470512.6666666666666RegionG4 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000590294-112305_3120354.3333333333333RegionG1 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000590294-112362_3650354.3333333333333RegionG3 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000590294-112444_4470354.3333333333333RegionG4 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000591088-110305_3120336.0RegionG1 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000591088-110362_3650336.0RegionG3 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000591088-110444_4470336.0RegionG4 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000591198-111305_3120568.0RegionG1 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000591198-111362_3650568.0RegionG3 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000591198-111444_4470568.0RegionG4 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000592951-110305_3120336.0RegionG1 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000592951-110362_3650336.0RegionG3 motif
HgeneSEPT9chr17:75303279chr17:56353063ENST00000592951-110444_4470336.0RegionG4 motif


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Fusion Gene Sequence for SEPT9-MPO


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>80525_80525_1_SEPT9-MPO_SEPT9_chr17_75303279_ENST00000427177_MPO_chr17_56353063_ENST00000225275_length(transcript)=2036nt_BP=202nt
ACTCCAGACGGCGGGCCGCCCCCTCTTCCCGCCTTCCTACTACCGGCCCAGGATTAGCGCCCTGGGAGCGCGCGCCCCGCTGCCTCGCCG
CCACACTTTCCTGGGAGCGGCGGCCACGGAGGCACCATGAAGAAGTCTTACTCAGGAGGCACGCGGACCTCCAGTGGCCGGCTCCGGAGG
CTTGGTGACTCCAGTGGCCCAGGGGACACCCGTTCCAGTGAGATGCCCGAGCTCACCTCCATGCACACCCTCTTACTTCGGGAGCACAAC
CGGCTGGCCACAGAGCTCAAGAGCCTGAACCCTAGGTGGGATGGGGAGAGGCTCTACCAGGAAGCCCGGAAGATCGTGGGGGCCATGGTC
CAGATCATCACTTACCGGGACTACCTGCCCCTGGTGCTGGGGCCAACGGCCATGAGGAAGTACCTGCCCACGTACCGTTCCTACAATGAC
TCAGTGGACCCACGCATCGCCAACGTCTTCACCAATGCCTTCCGCTACGGCCACACCCTCATCCAACCCTTCATGTTCCGCCTGGACAAT
CGGTACCAGCCCATGGAACCCAACCCCCGTGTCCCCCTCAGCAGGGTCTTTTTTGCCTCCTGGAGGGTCGTGCTGGAAGGTGGCATTGAC
CCCATCCTCCGGGGCCTCATGGCCACCCCTGCCAAGCTGAATCGTCAGAACCAAATTGCAGTGGATGAGATCCGGGAGCGATTGTTTGAG
CAGGTCATGAGGATTGGGCTGGACCTGCCTGCTCTGAACATGCAGCGCAGCAGGGACCACGGCCTCCCAGGATACAATGCCTGGAGGCGC
TTCTGTGGGCTCCCGCAGCCTGAAACTGTGGGCCAGCTGGGCACGGTGCTGAGGAACCTGAAATTGGCGAGGAAACTGATGGAGCAGTAT
GGCACGCCCAACAACATCGACATCTGGATGGGCGGCGTGTCCGAGCCTCTGAAGCGCAAAGGCCGCGTGGGCCCACTCCTCGCCTGCATC
ATCGGTACCCAGTTCAGGAAGCTCCGGGATGGTGATCGGTTTTGGTGGGAGAACGAGGGTGTGTTCAGCATGCAGCAGCGACAGGCCCTG
GCCCAGATCTCATTGCCCCGGATCATCTGCGACAACACAGGCATCACCACCGTGTCTAAGAACAACATCTTCATGTCCAACTCATATCCC
CGGGACTTTGTCAACTGCAGTACACTTCCTGCATTGAACCTGGCTTCCTGGAGGGAAGCCTCCTAGAGGCCAGGTAAGGGGGTGCAGCAG
TGAGGGGTATATCTGGGCTGGCCAGTTGGAACCACGGAGATCTCCTTGCCCTAGATGAGCCCAGCCCTGTTCTGGGTGCAGCTGAGAAAA
TGAGTGACTAGACGTTCATTTGTGTGCTCATGTATGTGCGAAGTATATAAATTGGCTTTTCATGCGTGTGTGTTGTCTGAACATGGGGAG
TGTTTCATGGGTTATGTGTATGTGCCATTTATGTGAGTGTGTGTTTGTGCTGATGAGAATACTGAGTATGTGGAAGGCAGCAGAGCGGAC
TGGTGAGGAGCACAGCTCAGGAACTAGACTGCCTGGGTTCCAATCCTGGCTCTGTGGCTTGCTAGCTATGTGACCTTGAGCAAATTACCC
TCCTTAAACAAGAGTTTTCTTCCTTGTAAATTACATCTGTCATGGTTTCTTGGAGGGCCCACTTGTATCCTCTGGTTCTTCATTTATTGA
GCACCTACTACATGCAAGGCACTGTACTAGGCGTGAGAAGCATATAGAGGCAAGAAAGAGATACCAAGATGCCATCTGTGTCCTGGTTAG
CAGAGCTGGACCAGTGGTGCCTTGGAGGGATAAGCCAGCTGCAGCTGGGCTGTGTGGTTGACTTATGGGCCCAGCCAGCCAGGCTCAGGC
CATGGCTCCCCTTTTTCTTCCTCACCCTGATTTCTTGCTTATTCACTGAAGTTCTCCTGAAGAGGAACTGGGCCTGTTGCCCTTTCTGTA

>80525_80525_1_SEPT9-MPO_SEPT9_chr17_75303279_ENST00000427177_MPO_chr17_56353063_ENST00000225275_length(amino acids)=369AA_BP=25
MKKSYSGGTRTSSGRLRRLGDSSGPGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLV
LGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAK
LNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGG
VSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPAL

--------------------------------------------------------------
>80525_80525_2_SEPT9-MPO_SEPT9_chr17_75303279_ENST00000427177_MPO_chr17_56353063_ENST00000340482_length(transcript)=2036nt_BP=202nt
ACTCCAGACGGCGGGCCGCCCCCTCTTCCCGCCTTCCTACTACCGGCCCAGGATTAGCGCCCTGGGAGCGCGCGCCCCGCTGCCTCGCCG
CCACACTTTCCTGGGAGCGGCGGCCACGGAGGCACCATGAAGAAGTCTTACTCAGGAGGCACGCGGACCTCCAGTGGCCGGCTCCGGAGG
CTTGGTGACTCCAGTGGCCCAGGGGACACCCGTTCCAGTGAGATGCCCGAGCTCACCTCCATGCACACCCTCTTACTTCGGGAGCACAAC
CGGCTGGCCACAGAGCTCAAGAGCCTGAACCCTAGGTGGGATGGGGAGAGGCTCTACCAGGAAGCCCGGAAGATCGTGGGGGCCATGGTC
CAGATCATCACTTACCGGGACTACCTGCCCCTGGTGCTGGGGCCAACGGCCATGAGGAAGTACCTGCCCACGTACCGTTCCTACAATGAC
TCAGTGGACCCACGCATCGCCAACGTCTTCACCAATGCCTTCCGCTACGGCCACACCCTCATCCAACCCTTCATGTTCCGCCTGGACAAT
CGGTACCAGCCCATGGAACCCAACCCCCGTGTCCCCCTCAGCAGGGTCTTTTTTGCCTCCTGGAGGGTCGTGCTGGAAGGTGGCATTGAC
CCCATCCTCCGGGGCCTCATGGCCACCCCTGCCAAGCTGAATCGTCAGAACCAAATTGCAGTGGATGAGATCCGGGAGCGATTGTTTGAG
CAGGTCATGAGGATTGGGCTGGACCTGCCTGCTCTGAACATGCAGCGCAGCAGGGACCACGGCCTCCCAGGATACAATGCCTGGAGGCGC
TTCTGTGGGCTCCCGCAGCCTGAAACTGTGGGCCAGCTGGGCACGGTGCTGAGGAACCTGAAATTGGCGAGGAAACTGATGGAGCAGTAT
GGCACGCCCAACAACATCGACATCTGGATGGGCGGCGTGTCCGAGCCTCTGAAGCGCAAAGGCCGCGTGGGCCCACTCCTCGCCTGCATC
ATCGGTACCCAGTTCAGGAAGCTCCGGGATGGTGATCGGTTTTGGTGGGAGAACGAGGGTGTGTTCAGCATGCAGCAGCGACAGGCCCTG
GCCCAGATCTCATTGCCCCGGATCATCTGCGACAACACAGGCATCACCACCGTGTCTAAGAACAACATCTTCATGTCCAACTCATATCCC
CGGGACTTTGTCAACTGCAGTACACTTCCTGCATTGAACCTGGCTTCCTGGAGGGAAGCCTCCTAGAGGCCAGGTAAGGGGGTGCAGCAG
TGAGGGGTATATCTGGGCTGGCCAGTTGGAACCACGGAGATCTCCTTGCCCTAGATGAGCCCAGCCCTGTTCTGGGTGCAGCTGAGAAAA
TGAGTGACTAGACGTTCATTTGTGTGCTCATGTATGTGCGAAGTATATAAATTGGCTTTTCATGCGTGTGTGTTGTCTGAACATGGGGAG
TGTTTCATGGGTTATGTGTATGTGCCATTTATGTGAGTGTGTGTTTGTGCTGATGAGAATACTGAGTATGTGGAAGGCAGCAGAGCGGAC
TGGTGAGGAGCACAGCTCAGGAACTAGACTGCCTGGGTTCCAATCCTGGCTCTGTGGCTTGCTAGCTATGTGACCTTGAGCAAATTACCC
TCCTTAAACAAGAGTTTTCTTCCTTGTAAATTACATCTGTCATGGTTTCTTGGAGGGCCCACTTGTATCCTCTGGTTCTTCATTTATTGA
GCACCTACTACATGCAAGGCACTGTACTAGGCGTGAGAAGCATATAGAGGCAAGAAAGAGATACCAAGATGCCATCTGTGTCCTGGTTAG
CAGAGCTGGACCAGTGGTGCCTTGGAGGGATAAGCCAGCTGCAGCTGGGCTGTGTGGTTGACTTATGGGCCCAGCCAGCCAGGCTCAGGC
CATGGCTCCCCTTTTTCTTCCTCACCCTGATTTCTTGCTTATTCACTGAAGTTCTCCTGAAGAGGAACTGGGCCTGTTGCCCTTTCTGTA

>80525_80525_2_SEPT9-MPO_SEPT9_chr17_75303279_ENST00000427177_MPO_chr17_56353063_ENST00000340482_length(amino acids)=369AA_BP=25
MKKSYSGGTRTSSGRLRRLGDSSGPGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLV
LGPTAMRKYLPTYRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAK
LNRQNQIAVDEIRERLFEQVMRIGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWMGG
VSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFVNCSTLPAL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SEPT9-MPO


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SEPT9-MPO


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SEPT9-MPO


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource