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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SERINC5-TTC39A (FusionGDB2 ID:80696)

Fusion Gene Summary for SERINC5-TTC39A

check button Fusion gene summary
Fusion gene informationFusion gene name: SERINC5-TTC39A
Fusion gene ID: 80696
HgeneTgene
Gene symbol

SERINC5

TTC39A

Gene ID

256987

22996

Gene nameserine incorporator 5tetratricopeptide repeat domain 39A
SynonymsC5orf12|TPO1C1orf34|DEME-6
Cytomap

5q14.1

1p32.3

Type of geneprotein-codingprotein-coding
Descriptionserine incorporator 5tetratricopeptide repeat protein 39ATPR repeat protein 39Adifferentially expressed in MCF7 with estradiol protein 6testicular tissue protein Li 213
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000507668, ENST00000509193, 
ENST00000512721, ENST00000512972, 
ENST00000513907, 		ENST00000262675, 
ENST00000262676, ENST00000371747, 
ENST00000371750, ENST00000451380, 
ENST00000530004, ENST00000534098, 
ENST00000413473, ENST00000447632, 
Fusion gene scores* DoF score15 X 10 X 9=13506 X 6 X 4=144
# samples 166
** MAII scorelog2(16/1350*10)=-3.07681559705083
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/144*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SERINC5 [Title/Abstract] AND TTC39A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSERINC5(79462206)-TTC39A(51787497), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSERINC5

GO:0009597

detection of virus

26416733|26416734

HgeneSERINC5

GO:0045087

innate immune response

26416733|26416734

HgeneSERINC5

GO:0051607

defense response to virus

26416733|26416734


check buttonFusion gene breakpoints across SERINC5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TTC39A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-CH-5771-01ASERINC5chr5

79462206

-TTC39Achr1

51787497

-
ChimerDB4PRADTCGA-CH-5771SERINC5chr5

79462206

-TTC39Achr1

51787497

-


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Fusion Gene ORF analysis for SERINC5-TTC39A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000507668ENST00000262675SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000507668ENST00000262676SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000507668ENST00000371747SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000507668ENST00000371750SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000507668ENST00000451380SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000509193ENST00000262675SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000509193ENST00000262676SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000509193ENST00000371747SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000509193ENST00000371750SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000509193ENST00000451380SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000512721ENST00000262675SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000512721ENST00000262676SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000512721ENST00000371747SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000512721ENST00000371750SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000512721ENST00000451380SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000512972ENST00000262675SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000512972ENST00000262676SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000512972ENST00000371747SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000512972ENST00000371750SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-5UTRENST00000512972ENST00000451380SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-intronENST00000507668ENST00000530004SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-intronENST00000507668ENST00000534098SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-intronENST00000509193ENST00000530004SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-intronENST00000509193ENST00000534098SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-intronENST00000512721ENST00000530004SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-intronENST00000512721ENST00000534098SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-intronENST00000512972ENST00000530004SERINC5chr5

79462206

-TTC39Achr1

51787497

-
5CDS-intronENST00000512972ENST00000534098SERINC5chr5

79462206

-TTC39Achr1

51787497

-
Frame-shiftENST00000507668ENST00000413473SERINC5chr5

79462206

-TTC39Achr1

51787497

-
Frame-shiftENST00000507668ENST00000447632SERINC5chr5

79462206

-TTC39Achr1

51787497

-
Frame-shiftENST00000509193ENST00000413473SERINC5chr5

79462206

-TTC39Achr1

51787497

-
Frame-shiftENST00000509193ENST00000447632SERINC5chr5

79462206

-TTC39Achr1

51787497

-
Frame-shiftENST00000512721ENST00000413473SERINC5chr5

79462206

-TTC39Achr1

51787497

-
Frame-shiftENST00000512721ENST00000447632SERINC5chr5

79462206

-TTC39Achr1

51787497

-
In-frameENST00000512972ENST00000413473SERINC5chr5

79462206

-TTC39Achr1

51787497

-
In-frameENST00000512972ENST00000447632SERINC5chr5

79462206

-TTC39Achr1

51787497

-
intron-3CDSENST00000513907ENST00000413473SERINC5chr5

79462206

-TTC39Achr1

51787497

-
intron-3CDSENST00000513907ENST00000447632SERINC5chr5

79462206

-TTC39Achr1

51787497

-
intron-5UTRENST00000513907ENST00000262675SERINC5chr5

79462206

-TTC39Achr1

51787497

-
intron-5UTRENST00000513907ENST00000262676SERINC5chr5

79462206

-TTC39Achr1

51787497

-
intron-5UTRENST00000513907ENST00000371747SERINC5chr5

79462206

-TTC39Achr1

51787497

-
intron-5UTRENST00000513907ENST00000371750SERINC5chr5

79462206

-TTC39Achr1

51787497

-
intron-5UTRENST00000513907ENST00000451380SERINC5chr5

79462206

-TTC39Achr1

51787497

-
intron-intronENST00000513907ENST00000530004SERINC5chr5

79462206

-TTC39Achr1

51787497

-
intron-intronENST00000513907ENST00000534098SERINC5chr5

79462206

-TTC39Achr1

51787497

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000512972SERINC5chr579462206-ENST00000447632TTC39Achr151787497-36539567712753660
ENST00000512972SERINC5chr579462206-ENST00000413473TTC39Achr151787497-35489567712648625

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000512972ENST00000447632SERINC5chr579462206-TTC39Achr151787497-0.0053946150.99460536
ENST00000512972ENST00000413473SERINC5chr579462206-TTC39Achr151787497-0.0051303520.9948697

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Fusion Genomic Features for SERINC5-TTC39A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SERINC5-TTC39A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:79462206/chr1:51787497)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-7135_26286488.3333333333333Compositional biasNote=Cys-rich
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-7125_26286462.0Compositional biasNote=Cys-rich
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-7145_26286358.3333333333333Compositional biasNote=Cys-rich
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-713111_124286488.3333333333333Topological domainExtracellular
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-713146_156286488.3333333333333Topological domainCytoplasmic
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-713178_198286488.3333333333333Topological domainExtracellular
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-7131_36286488.3333333333333Topological domainExtracellular
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-713220_230286488.3333333333333Topological domainCytoplasmic
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-713252_258286488.3333333333333Topological domainExtracellular
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-71358_89286488.3333333333333Topological domainCytoplasmic
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-712111_124286462.0Topological domainExtracellular
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-712146_156286462.0Topological domainCytoplasmic
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-712178_198286462.0Topological domainExtracellular
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-7121_36286462.0Topological domainExtracellular
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-712220_230286462.0Topological domainCytoplasmic
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-712252_258286462.0Topological domainExtracellular
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-71258_89286462.0Topological domainCytoplasmic
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-714111_124286358.3333333333333Topological domainExtracellular
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-714146_156286358.3333333333333Topological domainCytoplasmic
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-714178_198286358.3333333333333Topological domainExtracellular
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-7141_36286358.3333333333333Topological domainExtracellular
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-714220_230286358.3333333333333Topological domainCytoplasmic
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-714252_258286358.3333333333333Topological domainExtracellular
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-71458_89286358.3333333333333Topological domainCytoplasmic
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-713125_145286488.3333333333333TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-713157_177286488.3333333333333TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-713199_219286488.3333333333333TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-713231_251286488.3333333333333TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-713259_279286488.3333333333333TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-71337_57286488.3333333333333TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-71390_110286488.3333333333333TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-712125_145286462.0TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-712157_177286462.0TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-712199_219286462.0TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-712231_251286462.0TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-712259_279286462.0TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-71237_57286462.0TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-71290_110286462.0TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-714125_145286358.3333333333333TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-714157_177286358.3333333333333TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-714199_219286358.3333333333333TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-714231_251286358.3333333333333TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-714259_279286358.3333333333333TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-71437_57286358.3333333333333TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-71490_110286358.3333333333333TransmembraneHelical
TgeneTTC39Achr5:79462206chr1:51787497ENST00000262676011315_34810421.0RepeatNote=TPR 1
TgeneTTC39Achr5:79462206chr1:51787497ENST00000262676011505_53810421.0RepeatNote=TPR 2
TgeneTTC39Achr5:79462206chr1:51787497ENST00000262676011546_57910421.0RepeatNote=TPR 3
TgeneTTC39Achr5:79462206chr1:51787497ENST00000413473018315_34817582.0RepeatNote=TPR 1
TgeneTTC39Achr5:79462206chr1:51787497ENST00000413473018505_53817582.0RepeatNote=TPR 2
TgeneTTC39Achr5:79462206chr1:51787497ENST00000413473018546_57917582.0RepeatNote=TPR 3
TgeneTTC39Achr5:79462206chr1:51787497ENST00000447632018315_34814614.0RepeatNote=TPR 1
TgeneTTC39Achr5:79462206chr1:51787497ENST00000447632018505_53814614.0RepeatNote=TPR 2
TgeneTTC39Achr5:79462206chr1:51787497ENST00000447632018546_57914614.0RepeatNote=TPR 3
TgeneTTC39Achr5:79462206chr1:51787497ENST00000451380018315_34813578.0RepeatNote=TPR 1
TgeneTTC39Achr5:79462206chr1:51787497ENST00000451380018505_53813578.0RepeatNote=TPR 2
TgeneTTC39Achr5:79462206chr1:51787497ENST00000451380018546_57913578.0RepeatNote=TPR 3
TgeneTTC39Achr5:79462206chr1:51787497ENST0000053000407315_3480222.0RepeatNote=TPR 1
TgeneTTC39Achr5:79462206chr1:51787497ENST0000053000407505_5380222.0RepeatNote=TPR 2
TgeneTTC39Achr5:79462206chr1:51787497ENST0000053000407546_5790222.0RepeatNote=TPR 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-713280_311286488.3333333333333Topological domainCytoplasmic
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-713333_385286488.3333333333333Topological domainExtracellular
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-713407_423286488.3333333333333Topological domainCytoplasmic
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-712280_311286462.0Topological domainCytoplasmic
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-712333_385286462.0Topological domainExtracellular
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-712407_423286462.0Topological domainCytoplasmic
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-714280_311286358.3333333333333Topological domainCytoplasmic
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-714333_385286358.3333333333333Topological domainExtracellular
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-714407_423286358.3333333333333Topological domainCytoplasmic
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-713312_332286488.3333333333333TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000507668-713386_406286488.3333333333333TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-712312_332286462.0TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512721-712386_406286462.0TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-714312_332286358.3333333333333TransmembraneHelical
HgeneSERINC5chr5:79462206chr1:51787497ENST00000512972-714386_406286358.3333333333333TransmembraneHelical


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Fusion Gene Sequence for SERINC5-TTC39A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>80696_80696_1_SERINC5-TTC39A_SERINC5_chr5_79462206_ENST00000512972_TTC39A_chr1_51787497_ENST00000413473_length(transcript)=3548nt_BP=956nt
AGCTGCGGCTGAGCCCAGCGCTCGAGGCGCGAGGCAGCCAGGAGGGCCCGTGCGGCGCGGGGAGCCAGCGAGCGCGCCTTCGGCATTGGC
CGCCGCGATGTCAGCTCAGTGCTGTGCGGGCCAGCTGGCCTGCTGCTGTGGGTCTGCAGGCTGCTCTCTCTGCTGTGATTGCTGCCCCAG
GATTCGGCAGTCCCTCAGCACCCGCTTCATGTACGCCCTCTACTTCATTCTGGTCGTCGTCCTCTGCTGCATCATGATGTCAACAACCGT
GGCTCACAAGATGAAAGAGCACATTCCTTTTTTTGAAGATATGTGTAAAGGCATTAAAGCTGGTGACACCTGTGAGAAGCTGGTGGGATA
TTCTGCCGTGTATAGAGTCTGTTTTGGAATGGCTTGTTTCTTCTTTATCTTCTGTCTACTGACCTTGAAAATCAACAACAGCAAAAGTTG
TAGAGCTCATATTCACAATGGCTTTTGGTTCTTTAAACTTCTGCTGTTGGGGGCCATGTGCTCAGGAGCTTTCTTCATTCCAGATCAGGA
CACCTTTCTGAACGCCTGGCGCTATGTGGGAGCCGTCGGAGGCTTCCTCTTCATTGGCATCCAGCTCCTCCTGCTCGTGGAGTTTGCACA
TAAGTGGAACAAGAACTGGACAGCAGGCACAGCCAGTAACAAGCTGTGGTACGCCTCCCTGGCCCTGGTGACGCTCATCATGTATTCCAT
TGCCACTGGAGGCTTGGTTTTGATGGCAGTGTTTTATACACAGAAAGACAGCTGCATGGAAAACAAAATTCTGCTGGGAGTAAATGGAGG
CCTGTGCCTGCTTATATCATTGGTAGCCATCTCACCCTGGGTCCAAAATCGACAGCCACACTCGGGGCTCTTACAATCAGGGGTCATAAG
CTGCTATGTCACCTACCTCACCTTCTCAGCTCTGTCCAGCAAACCTGCAGAAGTAGGACTCCTGAGAGCAGCCTCCATGAGGCCCTGGAC
CAGTGCATGACCGCCCTGGACCTCTTCCTCACCAACCAGTTCTCAGAAGCACTCAGCTACCTCAAGCCCAGAACCAAGGAAAGCATGTAC
CACTCACTGACATATGCCACCATCCTGGAGATGCAGGCCATGATGACCTTTGACCCTCAGGACATCCTGCTTGCCGGCAACATGATGAAG
GAGGCACAGATGCTGTGTCAGAGGCACCGGAGGAAGTCTTCTGTAACAGATTCCTTCAGCAGCCTGGTGAACCGCCCCACGCTGGGCCAA
TTCACTGAAGAGGAAATCCACGCTGAGGTCTGCTATGCAGAGTGCCTGCTGCAGCGAGCAGCCCTGACCTTCCTGCAGGACGAGAACATG
GTGAGCTTCATCAAAGGCGGCATCAAAGTTCGAAACAGCTACCAGACCTACAAGGAGCTGGACAGCCTTGTTCAGTCCTCACAATACTGC
AAGGGTGAGAACCACCCGCACTTTGAAGGAGGAGTGAAGCTTGGTGTAGGGGCCTTCAACCTGACACTGTCCATGCTTCCTACTAGGATC
CTGAGGCTGTTGGAGTTTGTGGGGTTTTCAGGAAACAAGGACTATGGGCTGCTGCAGCTGGAGGAGGGAGCGTCAGGGCACAGCTTCCGC
TCTGTGCTCTGTGTCATGCTCCTGCTGTGCTACCACACCTTCCTCACCTTCGTGCTCGGTACTGGGAACGTCAACATCGAGGAGGCCGAG
AAGCTCTTGAAGCCCTACCTGAACCGGTACCCTAAGGGTGCCATCTTCCTGTTCTTTGCAGGGAGGATTGAAGTCATTAAAGGCAACATT
GATGCAGCCATCCGGCGTTTCGAGGAGTGCTGTGAGGCCCAGCAGCACTGGAAGCAGTTCCACCACATGTGCTACTGGGAGCTGATGTGG
TGCTTCACCTACAAGGGCCAGTGGAAGATGTCCTACTTCTACGCCGACCTGCTCAGCAAGGAGAACTGCTGGTCCAAGGCCACCTACATT
TACATGAAGGCCGCCTACCTCAGCATGTTTGGGAAGGAGGACCACAAGCCGTTCGGGGACGACGAAGTGGAATTATTTCGAGCTGTGCCA
GGCCTGAAGCTCAAGATTGCTGGGAAATCTCTACCCACAGAGAAGTTTGCCATCCGGAAGTCCCGGCGCTACTTCTCCTCCAACCCTATC
TCGCTGCCAGTGCCTGCTCTGGAAATGATGTACATCTGGAACGGCTACGCCGTGATTGGGAAGCAGCCGAAACTCACGGATGGGATACTT
GAGATTATCACTAAGGCTGAAGAGATGCTGGAGAAAGGCCCAGAGAACGAGTACTCAGTGGATGACGAGTGCTTGGTGAAATTGTTGAAA
GGCCTGTGTCTGAAATACCTGGGCCGTGTCCAGGAGGCCGAGGAGAATTTTAGGAGCATCTCTGCCAATGAAAAGAAGATTAAATATGAC
CACTACTTGATCCCAAACGCCCTGCTGGAGCTGGCCCTGCTGCTTATGGAGCAAGACAGAAACGAAGAGGCCATCAAACTTTTGGAATCT
GCCAAGCAAAACTACAAGAATTACTCCATGGAGTCAAGGACACACTTTCGAATCCAGGCAGCCACACTCCAAGCCAAGTCTTCCCTAGAG
AACAGCAGCAGATCCATGGTCTCATCAGTGTCCTTGTAGCTTTGTGCAGCAGTTCCGGGCTGGAAGACAGAGACAGCTGGACAGAGCTCC
TGAAAACATTTCAAAATACCCCCTCCCCCTGCCCTGCCCTGCCTTTGGGGTCCACCGGCACTCCAGTTGGATGGCACAACATAGTGTATC
CGTGCAGAAGCCGAGCTGGCATTTTCACCAGTGTAGCCAAGGGCCTTTGCCAAGGGCAGAGCAGGTGGAGCCCTCTGCCTGCCCTATCAC
ACATACGGGTACTTGCTTTTCACTGTGATGTTTAAGAGAATGTATGAACAGTTTACATTTTCCTTAGAAATACATTGATGGGATCACAGT
TGGCTTTAAAAACCAACAACAATCAACCACCTGTAAGTCTTTGTCTTCACCTATTATCATCTGGAGGTAAATCTCTTTATATGATGATGC
CAAAGGGCAAATTGCTTTTCAAATTCAGCAAGTTCTCAGCTTGTGTGACGGAAGGTCCTTCAGAGGACCTGAGGAATGCCTGGGAGAGGC
TAAGCCTCAGGCTTCAATGCTTCTGGGGTTGGGCATGAGGATGTACACAGACACCCACTACCTTACTACTCACACTTCATTTCACTCCTT
TTGTAAATTTCCAATTTAAAAATCAAGCACGTCTTTTTAGTGAGATAAAATCTGAGCTCTTCTGTAGAAAAATCAATCTCTACCAGTAGA
AAATGCCAGGGCTTGATGGAAGAGCTGTGTAGCCCTTTCTATGCCAAAGCCAGGAAATTTGGGGGGCAGGAGGAGGTTCTCAGAATCCAG
TCTGTATCTTTGCTGTATGCCAAACTGAAACCACTGGGAATAATTTATGAAACATAAAAATCTTCTGTACTTCACTCCAAGGTACATTTG

>80696_80696_1_SERINC5-TTC39A_SERINC5_chr5_79462206_ENST00000512972_TTC39A_chr1_51787497_ENST00000413473_length(amino acids)=625AA_BP=61
MHGKQNSAGSKWRPVPAYIIGSHLTLGPKSTATLGALTIRGHKLLCHLPHLLSSVQQTCRSRTPESSLHEALDQCMTALDLFLTNQFSEA
LSYLKPRTKESMYHSLTYATILEMQAMMTFDPQDILLAGNMMKEAQMLCQRHRRKSSVTDSFSSLVNRPTLGQFTEEEIHAEVCYAECLL
QRAALTFLQDENMVSFIKGGIKVRNSYQTYKELDSLVQSSQYCKGENHPHFEGGVKLGVGAFNLTLSMLPTRILRLLEFVGFSGNKDYGL
LQLEEGASGHSFRSVLCVMLLLCYHTFLTFVLGTGNVNIEEAEKLLKPYLNRYPKGAIFLFFAGRIEVIKGNIDAAIRRFEECCEAQQHW
KQFHHMCYWELMWCFTYKGQWKMSYFYADLLSKENCWSKATYIYMKAAYLSMFGKEDHKPFGDDEVELFRAVPGLKLKIAGKSLPTEKFA
IRKSRRYFSSNPISLPVPALEMMYIWNGYAVIGKQPKLTDGILEIITKAEEMLEKGPENEYSVDDECLVKLLKGLCLKYLGRVQEAEENF

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>80696_80696_2_SERINC5-TTC39A_SERINC5_chr5_79462206_ENST00000512972_TTC39A_chr1_51787497_ENST00000447632_length(transcript)=3653nt_BP=956nt
AGCTGCGGCTGAGCCCAGCGCTCGAGGCGCGAGGCAGCCAGGAGGGCCCGTGCGGCGCGGGGAGCCAGCGAGCGCGCCTTCGGCATTGGC
CGCCGCGATGTCAGCTCAGTGCTGTGCGGGCCAGCTGGCCTGCTGCTGTGGGTCTGCAGGCTGCTCTCTCTGCTGTGATTGCTGCCCCAG
GATTCGGCAGTCCCTCAGCACCCGCTTCATGTACGCCCTCTACTTCATTCTGGTCGTCGTCCTCTGCTGCATCATGATGTCAACAACCGT
GGCTCACAAGATGAAAGAGCACATTCCTTTTTTTGAAGATATGTGTAAAGGCATTAAAGCTGGTGACACCTGTGAGAAGCTGGTGGGATA
TTCTGCCGTGTATAGAGTCTGTTTTGGAATGGCTTGTTTCTTCTTTATCTTCTGTCTACTGACCTTGAAAATCAACAACAGCAAAAGTTG
TAGAGCTCATATTCACAATGGCTTTTGGTTCTTTAAACTTCTGCTGTTGGGGGCCATGTGCTCAGGAGCTTTCTTCATTCCAGATCAGGA
CACCTTTCTGAACGCCTGGCGCTATGTGGGAGCCGTCGGAGGCTTCCTCTTCATTGGCATCCAGCTCCTCCTGCTCGTGGAGTTTGCACA
TAAGTGGAACAAGAACTGGACAGCAGGCACAGCCAGTAACAAGCTGTGGTACGCCTCCCTGGCCCTGGTGACGCTCATCATGTATTCCAT
TGCCACTGGAGGCTTGGTTTTGATGGCAGTGTTTTATACACAGAAAGACAGCTGCATGGAAAACAAAATTCTGCTGGGAGTAAATGGAGG
CCTGTGCCTGCTTATATCATTGGTAGCCATCTCACCCTGGGTCCAAAATCGACAGCCACACTCGGGGCTCTTACAATCAGGGGTCATAAG
CTGCTATGTCACCTACCTCACCTTCTCAGCTCTGTCCAGCAAACCTGCAGAAGTAGGACTCCTGAGAGCAGCCTCCATGAGGCCCTGGAC
CAGTGCATGACCGCCCTGGACCTCTTCCTCACCAACCAGTTCTCAGAAGCACTCAGCTACCTCAAGCCCAGAACCAAGGAAAGCATGTAC
CACTCACTGACATATGCCACCATCCTGGAGATGCAGGCCATGATGACCTTTGACCCTCAGGACATCCTGCTTGCCGGCAACATGATGAAG
GAGGCACAGATGCTGTGTCAGAGGCACCGGAGGAAGTCTTCTGTAACAGATTCCTTCAGCAGCCTGGTGAACCGCCCCACGCTGGGCCAA
TTCACTGAAGAGGAAATCCACGCTGAGGTCTGCTATGCAGAGTGCCTGCTGCAGCGAGCAGCCCTGACCTTCCTGCAGGGTTCCTCACAC
GGAGGGGCAGTCAGGCCCAGAGCCTTGCATGATCCCTCTCACGCCTGCAGCTGCCCACCTGGGCCAGGCCGTCAGCATCTTTTCCTCCTG
CAGGACGAGAACATGGTGAGCTTCATCAAAGGCGGCATCAAAGTTCGAAACAGCTACCAGACCTACAAGGAGCTGGACAGCCTTGTTCAG
TCCTCACAATACTGCAAGGGTGAGAACCACCCGCACTTTGAAGGAGGAGTGAAGCTTGGTGTAGGGGCCTTCAACCTGACACTGTCCATG
CTTCCTACTAGGATCCTGAGGCTGTTGGAGTTTGTGGGGTTTTCAGGAAACAAGGACTATGGGCTGCTGCAGCTGGAGGAGGGAGCGTCA
GGGCACAGCTTCCGCTCTGTGCTCTGTGTCATGCTCCTGCTGTGCTACCACACCTTCCTCACCTTCGTGCTCGGTACTGGGAACGTCAAC
ATCGAGGAGGCCGAGAAGCTCTTGAAGCCCTACCTGAACCGGTACCCTAAGGGTGCCATCTTCCTGTTCTTTGCAGGGAGGATTGAAGTC
ATTAAAGGCAACATTGATGCAGCCATCCGGCGTTTCGAGGAGTGCTGTGAGGCCCAGCAGCACTGGAAGCAGTTCCACCACATGTGCTAC
TGGGAGCTGATGTGGTGCTTCACCTACAAGGGCCAGTGGAAGATGTCCTACTTCTACGCCGACCTGCTCAGCAAGGAGAACTGCTGGTCC
AAGGCCACCTACATTTACATGAAGGCCGCCTACCTCAGCATGTTTGGGAAGGAGGACCACAAGCCGTTCGGGGACGACGAAGTGGAATTA
TTTCGAGCTGTGCCAGGCCTGAAGCTCAAGATTGCTGGGAAATCTCTACCCACAGAGAAGTTTGCCATCCGGAAGTCCCGGCGCTACTTC
TCCTCCAACCCTATCTCGCTGCCAGTGCCTGCTCTGGAAATGATGTACATCTGGAACGGCTACGCCGTGATTGGGAAGCAGCCGAAACTC
ACGGATGGGATACTTGAGATTATCACTAAGGCTGAAGAGATGCTGGAGAAAGGCCCAGAGAACGAGTACTCAGTGGATGACGAGTGCTTG
GTGAAATTGTTGAAAGGCCTGTGTCTGAAATACCTGGGCCGTGTCCAGGAGGCCGAGGAGAATTTTAGGAGCATCTCTGCCAATGAAAAG
AAGATTAAATATGACCACTACTTGATCCCAAACGCCCTGCTGGAGCTGGCCCTGCTGCTTATGGAGCAAGACAGAAACGAAGAGGCCATC
AAACTTTTGGAATCTGCCAAGCAAAACTACAAGAATTACTCCATGGAGTCAAGGACACACTTTCGAATCCAGGCAGCCACACTCCAAGCC
AAGTCTTCCCTAGAGAACAGCAGCAGATCCATGGTCTCATCAGTGTCCTTGTAGCTTTGTGCAGCAGTTCCGGGCTGGAAGACAGAGACA
GCTGGACAGAGCTCCTGAAAACATTTCAAAATACCCCCTCCCCCTGCCCTGCCCTGCCTTTGGGGTCCACCGGCACTCCAGTTGGATGGC
ACAACATAGTGTATCCGTGCAGAAGCCGAGCTGGCATTTTCACCAGTGTAGCCAAGGGCCTTTGCCAAGGGCAGAGCAGGTGGAGCCCTC
TGCCTGCCCTATCACACATACGGGTACTTGCTTTTCACTGTGATGTTTAAGAGAATGTATGAACAGTTTACATTTTCCTTAGAAATACAT
TGATGGGATCACAGTTGGCTTTAAAAACCAACAACAATCAACCACCTGTAAGTCTTTGTCTTCACCTATTATCATCTGGAGGTAAATCTC
TTTATATGATGATGCCAAAGGGCAAATTGCTTTTCAAATTCAGCAAGTTCTCAGCTTGTGTGACGGAAGGTCCTTCAGAGGACCTGAGGA
ATGCCTGGGAGAGGCTAAGCCTCAGGCTTCAATGCTTCTGGGGTTGGGCATGAGGATGTACACAGACACCCACTACCTTACTACTCACAC
TTCATTTCACTCCTTTTGTAAATTTCCAATTTAAAAATCAAGCACGTCTTTTTAGTGAGATAAAATCTGAGCTCTTCTGTAGAAAAATCA
ATCTCTACCAGTAGAAAATGCCAGGGCTTGATGGAAGAGCTGTGTAGCCCTTTCTATGCCAAAGCCAGGAAATTTGGGGGGCAGGAGGAG
GTTCTCAGAATCCAGTCTGTATCTTTGCTGTATGCCAAACTGAAACCACTGGGAATAATTTATGAAACATAAAAATCTTCTGTACTTCAC

>80696_80696_2_SERINC5-TTC39A_SERINC5_chr5_79462206_ENST00000512972_TTC39A_chr1_51787497_ENST00000447632_length(amino acids)=660AA_BP=61
MHGKQNSAGSKWRPVPAYIIGSHLTLGPKSTATLGALTIRGHKLLCHLPHLLSSVQQTCRSRTPESSLHEALDQCMTALDLFLTNQFSEA
LSYLKPRTKESMYHSLTYATILEMQAMMTFDPQDILLAGNMMKEAQMLCQRHRRKSSVTDSFSSLVNRPTLGQFTEEEIHAEVCYAECLL
QRAALTFLQGSSHGGAVRPRALHDPSHACSCPPGPGRQHLFLLQDENMVSFIKGGIKVRNSYQTYKELDSLVQSSQYCKGENHPHFEGGV
KLGVGAFNLTLSMLPTRILRLLEFVGFSGNKDYGLLQLEEGASGHSFRSVLCVMLLLCYHTFLTFVLGTGNVNIEEAEKLLKPYLNRYPK
GAIFLFFAGRIEVIKGNIDAAIRRFEECCEAQQHWKQFHHMCYWELMWCFTYKGQWKMSYFYADLLSKENCWSKATYIYMKAAYLSMFGK
EDHKPFGDDEVELFRAVPGLKLKIAGKSLPTEKFAIRKSRRYFSSNPISLPVPALEMMYIWNGYAVIGKQPKLTDGILEIITKAEEMLEK
GPENEYSVDDECLVKLLKGLCLKYLGRVQEAEENFRSISANEKKIKYDHYLIPNALLELALLLMEQDRNEEAIKLLESAKQNYKNYSMES

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Fusion Gene PPI Analysis for SERINC5-TTC39A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SERINC5-TTC39A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SERINC5-TTC39A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource