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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SERPING1-A1BG (FusionGDB2 ID:80802)

Fusion Gene Summary for SERPING1-A1BG

Fusion gene summary

Fusion gene information	Fusion gene name: SERPING1-A1BG
	Fusion gene ID: 80802
		Hgene	Tgene
	Gene symbol	SERPING1	A1BG
	Gene ID	710	1
	Gene name	serpin family G member 1	alpha-1-B glycoprotein
	Synonyms	C1IN\|C1INH\|C1NH\|HAE1\|HAE2	A1B\|ABG\|GAB\|HYST2477
	Cytomap	11q12.1	19q13.43
	Type of gene	protein-coding	protein-coding
	Description	plasma protease C1 inhibitorC1 esterase inhibitorC1-inhibiting factorC1-inhibitorcomplement component 1 inhibitorepididymis secretory sperm binding proteinserine/cysteine proteinase inhibitor clade G member 1serpin G1serpin peptidase inhibitor cla	alpha-1B-glycoproteinHEL-S-163pAepididymis secretory sperm binding protein Li 163pA
	Modification date	20200313	20200313
	UniProtAcc	.	P04217
	Ensembl transtripts involved in fusion gene	ENST00000531605, ENST00000278407, ENST00000340687, ENST00000378323, ENST00000378324, ENST00000403558,	ENST00000263100, ENST00000596924,
Fusion gene scores	* DoF score	8 X 8 X 3=192	3 X 3 X 3=27
	# samples	8	3
	** MAII score	log2(8/192*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SERPING1 [Title/Abstract] AND A1BG [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SERPING1(57369642)-A1BG(58859006), # samples:1
Anticipated loss of major functional domain due to fusion event.	SERPING1-A1BG seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SERPING1	GO:0001869	negative regulation of complement activation, lectin pathway	10946292

Fusion gene breakpoints across SERPING1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across A1BG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-DD-A4NP-01A	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-

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Fusion Gene ORF analysis for SERPING1-A1BG

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000531605	ENST00000263100	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-
3UTR-3CDS	ENST00000531605	ENST00000596924	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-
Frame-shift	ENST00000278407	ENST00000596924	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-
Frame-shift	ENST00000340687	ENST00000596924	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-
Frame-shift	ENST00000378323	ENST00000596924	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-
Frame-shift	ENST00000378324	ENST00000596924	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-
Frame-shift	ENST00000403558	ENST00000596924	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-
In-frame	ENST00000278407	ENST00000263100	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-
In-frame	ENST00000340687	ENST00000263100	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-
In-frame	ENST00000378323	ENST00000263100	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-
In-frame	ENST00000378324	ENST00000263100	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-
In-frame	ENST00000403558	ENST00000263100	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000278407	SERPING1	chr11	57369642	+	ENST00000263100	A1BG	chr19	58859006	-	1380	912	143	1207	354
ENST00000340687	SERPING1	chr11	57369642	+	ENST00000263100	A1BG	chr19	58859006	-	1215	747	5	1042	345
ENST00000378323	SERPING1	chr11	57369642	+	ENST00000263100	A1BG	chr19	58859006	-	1225	757	0	1052	350
ENST00000378324	SERPING1	chr11	57369642	+	ENST00000263100	A1BG	chr19	58859006	-	1135	667	3	962	319
ENST00000403558	SERPING1	chr11	57369642	+	ENST00000263100	A1BG	chr19	58859006	-	1621	1153	366	1448	360

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000278407	ENST00000263100	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-	0.029923655	0.9700763
ENST00000340687	ENST00000263100	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-	0.030567875	0.9694322
ENST00000378323	ENST00000263100	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-	0.021523485	0.97847646
ENST00000378324	ENST00000263100	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-	0.14130665	0.85869336
ENST00000403558	ENST00000263100	SERPING1	chr11	57369642	+	A1BG	chr19	58859006	-	0.09575847	0.9042415

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Fusion Genomic Features for SERPING1-A1BG

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SERPING1-A1BG

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:57369642/chr19:58859006)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	A1BG P04217
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SERPING1

chr11:57369642

chr19:58859006

ENST00000278407

85_119

228

501.0

Region

Note=7 X 4 AA tandem repeats of [QE]-P-T-[TQ]

Hgene

SERPING1

chr11:57369642

chr19:58859006

ENST00000278407

101_104

228

501.0

Repeat

Note=5

Hgene

SERPING1

chr11:57369642

chr19:58859006

ENST00000278407

105_108

228

501.0

Repeat

Note=6

Hgene

SERPING1

chr11:57369642

chr19:58859006

ENST00000278407

116_119

228

501.0

Repeat

Note=7

Hgene

SERPING1

chr11:57369642

chr19:58859006

ENST00000278407

85_88

228

501.0

Repeat

Note=1

Hgene

SERPING1

chr11:57369642

chr19:58859006

ENST00000278407

89_92

228

501.0

Repeat

Note=2

Hgene

SERPING1

chr11:57369642

chr19:58859006

ENST00000278407

93_96

228

501.0

Repeat

Note=3

Hgene

SERPING1

chr11:57369642

chr19:58859006

ENST00000278407

97_100

228

501.0

Repeat

Note=4

Tgene

A1BG

chr11:57369642

chr19:58859006

ENST00000263100

398_495

397

496.0

Domain

Note=Ig-like V-type 5

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

A1BG

chr11:57369642

chr19:58859006

ENST00000263100

114_206

397

496.0

Domain

Note=Ig-like V-type 2

Tgene

A1BG

chr11:57369642

chr19:58859006

ENST00000263100

207_299

397

496.0

Domain

Note=Ig-like V-type 3

Tgene

A1BG

chr11:57369642

chr19:58859006

ENST00000263100

22_113

397

496.0

Domain

Note=Ig-like V-type 1

Tgene

A1BG

chr11:57369642

chr19:58859006

ENST00000263100

300_397

397

496.0

Domain

Note=Ig-like V-type 4

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Fusion Gene Sequence for SERPING1-A1BG

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>80802_80802_1_SERPING1-A1BG_SERPING1_chr11_57369642_ENST00000278407_A1BG_chr19_58859006_ENST00000263100_length(transcript)=1380nt_BP=912nt
AAGAAGACCAAGCGGTCAGTCCCATTCCGTCCCATCCTGATTTACAGGAACTCACACCAGCGATCAATCTTCCTTAATTTGTAACTGGGC
AGTGTCCCGGGCCAGCCAATAGCTAAGACTGCCCCCCCCGCACCCCACCCTCCCTGACCCTGGGGGACTCTCTACTCAGTCTGCACTGGA
GCTGCCTGGTGACCAGAAGTTTGGAGTCCGCTGACGTCGCCGCCCAGATGGCCTCCAGGCTGACCCTGCTGACCCTCCTGCTGCTGCTGC
TGGCTGGGGATAGAGCCTCCTCAAATCCAAATGCTACCAGCTCCAGCTCCCAGGATCCAGAGAGTTTGCAAGACAGAGGCGAAGGGAAGG
TCGCAACAACAGTTATCTCCAAGATGCTATTCGTTGAACCCATCCTGGAGGTTTCCAGCTTGCCGACAACCAACTCAACAACCAATTCAG
CCACCAAAATAACAGCTAATACCACTGATGAACCCACCACACAACCCACCACAGAGCCCACCACCCAACCCACCATCCAACCCACCCAAC
CAACTACCCAGCTCCCAACAGATTCTCCTACCCAGCCCACTACTGGGTCCTTCTGCCCAGGACCTGTTACTCTCTGCTCTGACTTGGAGA
GTCATTCAACAGAGGCCGTGTTGGGGGATGCTTTGGTAGATTTCTCCCTGAAGCTCTACCACGCCTTCTCAGCAATGAAGAAGGTGGAGA
CCAACATGGCCTTTTCCCCATTCAGCATCGCCAGCCTCCTTACCCAGGTCCTGCTCGGGGCTGGGGAGAACACCAAAACAAACCTGGAGA
GCATCCTCTCTTACCCCAAGGACTTCACCTGTGTCCACCAGGCCCTGAAGGGCTTCACGACCAAAGGTGTCACCTCAGTCTCTCAGATCT
TCCACAGCCCAGGACCCCCTCCCAGGCCTCAGCTCCGGGCGACGTGGAGTGGGGCGGTCCTGGCGGGCCGAGATGCCGTCCTGCGCTGCG
AGGGACCCATCCCCGACGTCACCTTCGAGCTGCTGCGCGAGGGCGAGACGAAGGCCGTGAAGACGGTCCGCACCCCCGGGGCCGCGGCGA
ACCTCGAGCTGATCTTCGTGGGGCCCCAGCACGCCGGCAACTACAGGTGCCGCTACCGCTCCTGGGTGCCCCACACCTTCGAATCGGAGC
TCAGCGACCCTGTGGAGCTCCTGGTGGCAGAAAGCTGATGCAGCCGCGGGCCCAGGGTGCTGTTGGTGTCCTCAGAAGTGCCGGGGATTC
TGGACTGGCTCCCTCCCCTCCTGTTGCAGCACAAGGCCGGGGTCTCTGGGGGGCTGGAGAAGCCTCCCTCATTCCTCCCAGGAATTAATA

>80802_80802_1_SERPING1-A1BG_SERPING1_chr11_57369642_ENST00000278407_A1BG_chr19_58859006_ENST00000263100_length(amino acids)=354AA_BP=255
MTLGDSLLSLHWSCLVTRSLESADVAAQMASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPILEV
SSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLESHSTEAVLGDALVDFSLK
LYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPGPPPRPQLRATWSG

--------------------------------------------------------------
>80802_80802_2_SERPING1-A1BG_SERPING1_chr11_57369642_ENST00000340687_A1BG_chr19_58859006_ENST00000263100_length(transcript)=1215nt_BP=747nt
TCAGTCTGCACTGGAGCTGCCTGGTGACCAGAAGTTTGGAGTCCGCTGACGTCGCCGCCCAGATGGCCTCCAGGCTGACCCTGCTGACCC
TCCTGCTGCTGCTGCTGGCTGGGGATAGAGCCTCCTCAAATCCAAATGCTACCAGCTCCAGCTCCCAGGATCCAGAGAGTTTGCAAGACA
GAGGCGAAGGGAAGGTCGCAACAACAGTTATCTCCAAGATGCTATTCGTTGAACCCATCCTGGAGGTTTCCAGCTTGCCGACAACCAACT
CAACAACCAATTCAGCCACCAAAATAACAGCTAATACCACTGATGAACCCACCACACAACCCACCACAGAGCCCACCACCCAACCCACCA
TCCAACCCACCCAACCAACTACCCAGCTCCCAACAGATTCTCCTACCCAGCCCACTACTGGGTCCTTCTGCCCAGGACCTGTTACTCTCT
GCTCTGACTTGGAGAGTCATTCAACAGAGGCCGTGTTGGGGGATGCTTTGGTAGATTTCTCCCTGAAGCTCTACCACGCCTTCTCAGCAA
TGAAGAAGGTGGAGACCAACATGGCCTTTTCCCCATTCAGCATCGCCAGCCTCCTTACCCAGGTCCTGCTCGGGGCTGGGGAGAACACCA
AAACAAACCTGGAGAGCATCCTCTCTTACCCCAAGGACTTCACCTGTGTCCACCAGGCCCTGAAGGGCTTCACGACCAAAGGTGTCACCT
CAGTCTCTCAGATCTTCCACAGCCCAGGACCCCCTCCCAGGCCTCAGCTCCGGGCGACGTGGAGTGGGGCGGTCCTGGCGGGCCGAGATG
CCGTCCTGCGCTGCGAGGGACCCATCCCCGACGTCACCTTCGAGCTGCTGCGCGAGGGCGAGACGAAGGCCGTGAAGACGGTCCGCACCC
CCGGGGCCGCGGCGAACCTCGAGCTGATCTTCGTGGGGCCCCAGCACGCCGGCAACTACAGGTGCCGCTACCGCTCCTGGGTGCCCCACA
CCTTCGAATCGGAGCTCAGCGACCCTGTGGAGCTCCTGGTGGCAGAAAGCTGATGCAGCCGCGGGCCCAGGGTGCTGTTGGTGTCCTCAG
AAGTGCCGGGGATTCTGGACTGGCTCCCTCCCCTCCTGTTGCAGCACAAGGCCGGGGTCTCTGGGGGGCTGGAGAAGCCTCCCTCATTCC

>80802_80802_2_SERPING1-A1BG_SERPING1_chr11_57369642_ENST00000340687_A1BG_chr19_58859006_ENST00000263100_length(amino acids)=345AA_BP=246
MHWSCLVTRSLESADVAAQMASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPILEVSSLPTTNST
TNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMK
KVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPGPPPRPQLRATWSGAVLAGRDAV

--------------------------------------------------------------
>80802_80802_3_SERPING1-A1BG_SERPING1_chr11_57369642_ENST00000378323_A1BG_chr19_58859006_ENST00000263100_length(transcript)=1225nt_BP=757nt
CTGCACTGGAGCTGCCTGGTGACCAGAAGTTTGGAGTCCGCTGACGTCGCCGCCCAGATGGCCTCCAGGCTGACCCTGCTGACCCTCCTG
CTGCTGCTGCTGGCTGGGTTTCTTGAACCACAGGATAGAGCCTCCTCAAATCCAAATGCTACCAGCTCCAGCTCCCAGGATCCAGAGAGT
TTGCAAGACAGAGGCGAAGGGAAGGTCGCAACAACAGTTATCTCCAAGATGCTATTCGTTGAACCCATCCTGGAGGTTTCCAGCTTGCCG
ACAACCAACTCAACAACCAATTCAGCCACCAAAATAACAGCTAATACCACTGATGAACCCACCACACAACCCACCACAGAGCCCACCACC
CAACCCACCATCCAACCCACCCAACCAACTACCCAGCTCCCAACAGATTCTCCTACCCAGCCCACTACTGGGTCCTTCTGCCCAGGACCT
GTTACTCTCTGCTCTGACTTGGAGAGTCATTCAACAGAGGCCGTGTTGGGGGATGCTTTGGTAGATTTCTCCCTGAAGCTCTACCACGCC
TTCTCAGCAATGAAGAAGGTGGAGACCAACATGGCCTTTTCCCCATTCAGCATCGCCAGCCTCCTTACCCAGGTCCTGCTCGGGGCTGGG
GAGAACACCAAAACAAACCTGGAGAGCATCCTCTCTTACCCCAAGGACTTCACCTGTGTCCACCAGGCCCTGAAGGGCTTCACGACCAAA
GGTGTCACCTCAGTCTCTCAGATCTTCCACAGCCCAGGACCCCCTCCCAGGCCTCAGCTCCGGGCGACGTGGAGTGGGGCGGTCCTGGCG
GGCCGAGATGCCGTCCTGCGCTGCGAGGGACCCATCCCCGACGTCACCTTCGAGCTGCTGCGCGAGGGCGAGACGAAGGCCGTGAAGACG
GTCCGCACCCCCGGGGCCGCGGCGAACCTCGAGCTGATCTTCGTGGGGCCCCAGCACGCCGGCAACTACAGGTGCCGCTACCGCTCCTGG
GTGCCCCACACCTTCGAATCGGAGCTCAGCGACCCTGTGGAGCTCCTGGTGGCAGAAAGCTGATGCAGCCGCGGGCCCAGGGTGCTGTTG
GTGTCCTCAGAAGTGCCGGGGATTCTGGACTGGCTCCCTCCCCTCCTGTTGCAGCACAAGGCCGGGGTCTCTGGGGGGCTGGAGAAGCCT

>80802_80802_3_SERPING1-A1BG_SERPING1_chr11_57369642_ENST00000378323_A1BG_chr19_58859006_ENST00000263100_length(amino acids)=350AA_BP=251
LHWSCLVTRSLESADVAAQMASRLTLLTLLLLLLAGFLEPQDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPILEVSSLP
TTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHA
FSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPGPPPRPQLRATWSGAVLA

--------------------------------------------------------------
>80802_80802_4_SERPING1-A1BG_SERPING1_chr11_57369642_ENST00000378324_A1BG_chr19_58859006_ENST00000263100_length(transcript)=1135nt_BP=667nt
GCACTGGAGCTGCCTGGTGACCAGAAGTTTGGAGATAGAGCCTCCTCAAATCCAAATGCTACCAGCTCCAGCTCCCAGGATCCAGAGAGT
TTGCAAGACAGAGGCGAAGGGAAGGTCGCAACAACAGTTATCTCCAAGATGCTATTCGTTGAACCCATCCTGGAGGTTTCCAGCTTGCCG
ACAACCAACTCAACAACCAATTCAGCCACCAAAATAACAGCTAATACCACTGATGAACCCACCACACAACCCACCACAGAGCCCACCACC
CAACCCACCATCCAACCCACCCAACCAACTACCCAGCTCCCAACAGATTCTCCTACCCAGCCCACTACTGGGTCCTTCTGCCCAGGACCT
GTTACTCTCTGCTCTGACTTGGAGAGTCATTCAACAGAGGCCGTGTTGGGGGATGCTTTGGTAGATTTCTCCCTGAAGCTCTACCACGCC
TTCTCAGCAATGAAGAAGGTGGAGACCAACATGGCCTTTTCCCCATTCAGCATCGCCAGCCTCCTTACCCAGGTCCTGCTCGGGGCTGGG
GAGAACACCAAAACAAACCTGGAGAGCATCCTCTCTTACCCCAAGGACTTCACCTGTGTCCACCAGGCCCTGAAGGGCTTCACGACCAAA
GGTGTCACCTCAGTCTCTCAGATCTTCCACAGCCCAGGACCCCCTCCCAGGCCTCAGCTCCGGGCGACGTGGAGTGGGGCGGTCCTGGCG
GGCCGAGATGCCGTCCTGCGCTGCGAGGGACCCATCCCCGACGTCACCTTCGAGCTGCTGCGCGAGGGCGAGACGAAGGCCGTGAAGACG
GTCCGCACCCCCGGGGCCGCGGCGAACCTCGAGCTGATCTTCGTGGGGCCCCAGCACGCCGGCAACTACAGGTGCCGCTACCGCTCCTGG
GTGCCCCACACCTTCGAATCGGAGCTCAGCGACCCTGTGGAGCTCCTGGTGGCAGAAAGCTGATGCAGCCGCGGGCCCAGGGTGCTGTTG
GTGTCCTCAGAAGTGCCGGGGATTCTGGACTGGCTCCCTCCCCTCCTGTTGCAGCACAAGGCCGGGGTCTCTGGGGGGCTGGAGAAGCCT

>80802_80802_4_SERPING1-A1BG_SERPING1_chr11_57369642_ENST00000378324_A1BG_chr19_58859006_ENST00000263100_length(amino acids)=319AA_BP=220
MELPGDQKFGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFVEPILEVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQ
PTIQPTQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLESHSTEAVLGDALVDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGE
NTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPGPPPRPQLRATWSGAVLAGRDAVLRCEGPIPDVTFELLREGETKAVKTV

--------------------------------------------------------------
>80802_80802_5_SERPING1-A1BG_SERPING1_chr11_57369642_ENST00000403558_A1BG_chr19_58859006_ENST00000263100_length(transcript)=1621nt_BP=1153nt
CCCGCCTTCCTGCCCGCCTTGATCTCGGGGGTCTCTATAGGCTTGCTTCCACCTGGGACTTCTGCCTCCTCCTACCCCAGCCCCTCCCGC
CTCAGGCCTGTTGTGCTCAGCCCCCCAGGACCTCCCCTCCCCCACGCCTCTGGCCTCATTGTTTGGTTAAAGCAGGACCCCCTCCCCCTC
CCACCACCTCCCCTCCGACTGAACAGATGGACAGAGACCCGGGCCCACGGGGAGAGGAAGGGCCAGCCGGTGCCGGGAAAGGGAAGCGGT
TTGGGGAAAACAAAACAGAGGGAGGAGCCAGGGAGAAGGTGGCCCCAGGAGGGAGGAGGAGGGAATTCGCTAAGAGGGACTGGGGCCTGA
GACGGAATGGGGGCGGGCCCCGGGCGGGGTGGGGGCCCCTGGGCTCCCAGGGTGGGAGCTGGCTCCGAGGCTGGCTGGCTCCGCAGGTCC
GCTGACGTCGCCGCCCAGATGGCCTCCAGGCTGACCCTGCTGACCCTCCTGCTGCTGCTGCTGGCTGGGGATAGAGCCTCCTCAAATCCA
AATGCTACCAGCTCCAGCTCCCAGGATCCAGAGAGTTTGCAAGACAGAGGCGAAGGGAAGGTCGCAACAACAGTTATCTCCAAGATGCTA
TTCGTTGAACCCATCCTGGAGGTTTCCAGCTTGCCGACAACCAACTCAACAACCAATTCAGCCACCAAAATAACAGCTAATACCACTGAT
GAACCCACCACACAACCCACCACAGAGCCCACCACCCAACCCACCATCCAACCCACCCAACCAACTACCCAGCTCCCAACAGATTCTCCT
ACCCAGCCCACTACTGGGTCCTTCTGCCCAGGACCTGTTACTCTCTGCTCTGACTTGGAGAGTCATTCAACAGAGGCCGTGTTGGGGGAT
GCTTTGGTAGATTTCTCCCTGAAGCTCTACCACGCCTTCTCAGCAATGAAGAAGGTGGAGACCAACATGGCCTTTTCCCCATTCAGCATC
GCCAGCCTCCTTACCCAGGTCCTGCTCGGGGCTGGGGAGAACACCAAAACAAACCTGGAGAGCATCCTCTCTTACCCCAAGGACTTCACC
TGTGTCCACCAGGCCCTGAAGGGCTTCACGACCAAAGGTGTCACCTCAGTCTCTCAGATCTTCCACAGCCCAGGACCCCCTCCCAGGCCT
CAGCTCCGGGCGACGTGGAGTGGGGCGGTCCTGGCGGGCCGAGATGCCGTCCTGCGCTGCGAGGGACCCATCCCCGACGTCACCTTCGAG
CTGCTGCGCGAGGGCGAGACGAAGGCCGTGAAGACGGTCCGCACCCCCGGGGCCGCGGCGAACCTCGAGCTGATCTTCGTGGGGCCCCAG
CACGCCGGCAACTACAGGTGCCGCTACCGCTCCTGGGTGCCCCACACCTTCGAATCGGAGCTCAGCGACCCTGTGGAGCTCCTGGTGGCA
GAAAGCTGATGCAGCCGCGGGCCCAGGGTGCTGTTGGTGTCCTCAGAAGTGCCGGGGATTCTGGACTGGCTCCCTCCCCTCCTGTTGCAG
CACAAGGCCGGGGTCTCTGGGGGGCTGGAGAAGCCTCCCTCATTCCTCCCAGGAATTAATAAATGTGAAGAGAGGCTCTGTTTAAAATGT

>80802_80802_5_SERPING1-A1BG_SERPING1_chr11_57369642_ENST00000403558_A1BG_chr19_58859006_ENST00000263100_length(amino acids)=360AA_BP=261
MGAGPGRGGGPWAPRVGAGSEAGWLRRSADVAAQMASRLTLLTLLLLLLAGDRASSNPNATSSSSQDPESLQDRGEGKVATTVISKMLFV
EPILEVSSLPTTNSTTNSATKITANTTDEPTTQPTTEPTTQPTIQPTQPTTQLPTDSPTQPTTGSFCPGPVTLCSDLESHSTEAVLGDAL
VDFSLKLYHAFSAMKKVETNMAFSPFSIASLLTQVLLGAGENTKTNLESILSYPKDFTCVHQALKGFTTKGVTSVSQIFHSPGPPPRPQL
RATWSGAVLAGRDAVLRCEGPIPDVTFELLREGETKAVKTVRTPGAAANLELIFVGPQHAGNYRCRYRSWVPHTFESELSDPVELLVAES

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Fusion Gene PPI Analysis for SERPING1-A1BG

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SERPING1-A1BG

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SERPING1-A1BG

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source