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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SET-BRD1 (FusionGDB2 ID:80856)

Fusion Gene Summary for SET-BRD1

check button Fusion gene summary
Fusion gene informationFusion gene name: SET-BRD1
Fusion gene ID: 80856
HgeneTgene
Gene symbol

SET

BRD1

Gene ID

6418

23774

Gene nameSET nuclear proto-oncogenebromodomain containing 1
Synonyms2PP2A|I2PP2A|IGAAD|IPP2A2|MRD58|PHAPII|TAF-I|TAF-IBETABRL|BRPF1|BRPF2
Cytomap

9q34.11

22q13.33

Type of geneprotein-codingprotein-coding
Descriptionprotein SETHLA-DR-associated protein IISET nuclear oncogeneSET translocation (myeloid leukemia-associated)Template-Activating Factor-I, chromatin remodelling factorchromatin remodelling factorinhibitor of granzyme A-activated DNaseinhibitor-2 of prbromodomain-containing protein 1BR140-like proteinbromodomain and PHD finger-containing protein 2
Modification date2020031320200327
UniProtAcc

SETD9

O95696

Ensembl transtripts involved in fusion geneENST00000322030, ENST00000372688, 
ENST00000372692, ENST00000409104, 
ENST00000477806, 		ENST00000459821, 
ENST00000457780, ENST00000216267, 
ENST00000342989, ENST00000404034, 
ENST00000404760, ENST00000542442, 
Fusion gene scores* DoF score16 X 14 X 3=6726 X 7 X 4=168
# samples 177
** MAII scorelog2(17/672*10)=-1.98292648664106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SET [Title/Abstract] AND BRD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSET(131451934)-BRD1(50171461), # samples:1
Anticipated loss of major functional domain due to fusion event.SET-BRD1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
SET-BRD1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SET-BRD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SET-BRD1 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SET-BRD1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SET-BRD1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSET

GO:0045892

negative regulation of transcription, DNA-templated

19343227

TgeneBRD1

GO:0043966

histone H3 acetylation

16387653


check buttonFusion gene breakpoints across SET (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A8PESETchr9

131451934

+BRD1chr22

50171461

-


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Fusion Gene ORF analysis for SET-BRD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000322030ENST00000459821SETchr9

131451934

+BRD1chr22

50171461

-
Frame-shiftENST00000322030ENST00000457780SETchr9

131451934

+BRD1chr22

50171461

-
In-frameENST00000322030ENST00000216267SETchr9

131451934

+BRD1chr22

50171461

-
In-frameENST00000322030ENST00000342989SETchr9

131451934

+BRD1chr22

50171461

-
In-frameENST00000322030ENST00000404034SETchr9

131451934

+BRD1chr22

50171461

-
In-frameENST00000322030ENST00000404760SETchr9

131451934

+BRD1chr22

50171461

-
In-frameENST00000322030ENST00000542442SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000372688ENST00000216267SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000372688ENST00000342989SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000372688ENST00000404034SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000372688ENST00000404760SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000372688ENST00000457780SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000372688ENST00000542442SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000372692ENST00000216267SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000372692ENST00000342989SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000372692ENST00000404034SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000372692ENST00000404760SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000372692ENST00000457780SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000372692ENST00000542442SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000409104ENST00000216267SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000409104ENST00000342989SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000409104ENST00000404034SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000409104ENST00000404760SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000409104ENST00000457780SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000409104ENST00000542442SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000477806ENST00000216267SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000477806ENST00000342989SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000477806ENST00000404034SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000477806ENST00000404760SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000477806ENST00000457780SETchr9

131451934

+BRD1chr22

50171461

-
intron-3CDSENST00000477806ENST00000542442SETchr9

131451934

+BRD1chr22

50171461

-
intron-intronENST00000372688ENST00000459821SETchr9

131451934

+BRD1chr22

50171461

-
intron-intronENST00000372692ENST00000459821SETchr9

131451934

+BRD1chr22

50171461

-
intron-intronENST00000409104ENST00000459821SETchr9

131451934

+BRD1chr22

50171461

-
intron-intronENST00000477806ENST00000459821SETchr9

131451934

+BRD1chr22

50171461

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000322030SETchr9131451934+ENST00000216267BRD1chr2250171461-20934303571142261
ENST00000322030SETchr9131451934+ENST00000404034BRD1chr2250171461-20934303571142261
ENST00000322030SETchr9131451934+ENST00000404760BRD1chr2250171461-20934303571142261
ENST00000322030SETchr9131451934+ENST00000542442BRD1chr2250171461-15584303571142261
ENST00000322030SETchr9131451934+ENST00000342989BRD1chr2250171461-15494303571142261

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000322030ENST00000216267SETchr9131451934+BRD1chr2250171461-0.0086620930.9913379
ENST00000322030ENST00000404034SETchr9131451934+BRD1chr2250171461-0.0086620930.9913379
ENST00000322030ENST00000404760SETchr9131451934+BRD1chr2250171461-0.0086620930.9913379
ENST00000322030ENST00000542442SETchr9131451934+BRD1chr2250171461-0.0260948610.9739051
ENST00000322030ENST00000342989SETchr9131451934+BRD1chr2250171461-0.0274742840.9725257

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Fusion Genomic Features for SET-BRD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SET-BRD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:131451934/chr22:50171461)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SET

SETD9

BRD1

O95696

299FUNCTION: Scaffold subunit of various histone acetyltransferase (HAT) complexes, such as the MOZ/MORF and HBO1 complexes, that acts as a regulator of hematopoiesis (PubMed:16387653, PubMed:21753189, PubMed:21880731). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H3 'Lys-14' acetylation (H3K14ac), thereby promoting erythroid differentiation (PubMed:21753189). {ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:21753189, ECO:0000269|PubMed:21880731}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBRD1chr9:131451934chr22:50171461ENST00000216267612929_10128211059.0DomainPWWP
TgeneBRD1chr9:131451934chr22:50171461ENST00000404034713929_10128211059.0DomainPWWP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSETchr9:131451934chr22:50171461ENST00000322030+18239_29024278.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneSETchr9:131451934chr22:50171461ENST00000372688+18239_2900267.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneSETchr9:131451934chr22:50171461ENST00000372692+18239_2900291.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneSETchr9:131451934chr22:50171461ENST00000409104+18239_2900269.0Compositional biasNote=Asp/Glu-rich (highly acidic)
HgeneSETchr9:131451934chr22:50171461ENST00000322030+1831_7824278.0RegionNote=Dimerization
HgeneSETchr9:131451934chr22:50171461ENST00000322030+1879_22524278.0RegionNote=Earmuff domain
HgeneSETchr9:131451934chr22:50171461ENST00000372688+1831_780267.0RegionNote=Dimerization
HgeneSETchr9:131451934chr22:50171461ENST00000372688+1879_2250267.0RegionNote=Earmuff domain
HgeneSETchr9:131451934chr22:50171461ENST00000372692+1831_780291.0RegionNote=Dimerization
HgeneSETchr9:131451934chr22:50171461ENST00000372692+1879_2250291.0RegionNote=Earmuff domain
HgeneSETchr9:131451934chr22:50171461ENST00000409104+1831_780269.0RegionNote=Dimerization
HgeneSETchr9:131451934chr22:50171461ENST00000409104+1879_2250269.0RegionNote=Earmuff domain
TgeneBRD1chr9:131451934chr22:50171461ENST00000216267612579_6498211059.0DomainBromo
TgeneBRD1chr9:131451934chr22:50171461ENST00000404034713579_6498211059.0DomainBromo
TgeneBRD1chr9:131451934chr22:50171461ENST00000404760713579_6499521190.0DomainBromo
TgeneBRD1chr9:131451934chr22:50171461ENST00000404760713929_10129521190.0DomainPWWP
TgeneBRD1chr9:131451934chr22:50171461ENST00000216267612214_2648211059.0Zinc fingerPHD-type 1
TgeneBRD1chr9:131451934chr22:50171461ENST00000216267612268_3018211059.0Zinc fingerC2HC pre-PHD-type
TgeneBRD1chr9:131451934chr22:50171461ENST00000216267612325_3898211059.0Zinc fingerPHD-type 2
TgeneBRD1chr9:131451934chr22:50171461ENST00000404034713214_2648211059.0Zinc fingerPHD-type 1
TgeneBRD1chr9:131451934chr22:50171461ENST00000404034713268_3018211059.0Zinc fingerC2HC pre-PHD-type
TgeneBRD1chr9:131451934chr22:50171461ENST00000404034713325_3898211059.0Zinc fingerPHD-type 2
TgeneBRD1chr9:131451934chr22:50171461ENST00000404760713214_2649521190.0Zinc fingerPHD-type 1
TgeneBRD1chr9:131451934chr22:50171461ENST00000404760713268_3019521190.0Zinc fingerC2HC pre-PHD-type
TgeneBRD1chr9:131451934chr22:50171461ENST00000404760713325_3899521190.0Zinc fingerPHD-type 2


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Fusion Gene Sequence for SET-BRD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>80856_80856_1_SET-BRD1_SET_chr9_131451934_ENST00000322030_BRD1_chr22_50171461_ENST00000216267_length(transcript)=2093nt_BP=430nt
CGCCGTAGGAGGAGGTGGAGGAGGAGGCGGCTCGGGAGAGCGAGCAGCGAGCTGGCTGGATCGCCGAGCGCGAGTGAGGGAGCCGAGCCG
CCCGCCGCCGCCGCCTCCGCCTCCCCTCCGCGAACAGGAGCCCGGGCCGGGGCCCGGCACGCCGCCCCAGCCCGTCCCTCGGCGTCAGGC
CGCGAGGGTAGCGCGCGCGAGCGAGCGAGGGGGAGGGAGAGCGAGCGAGCGCCGGGAGGAGGCGGCCGGACCGAGCGGGCGCCCGCGCGT
GTGGCGTGAGGGGAAGCCGCTTGCCCGCCCCCTTCGCCTTCCCTTCTCTCCCCCTCCCCGCTCCCCCCCCGACCGCGGAGCAGCACCATG
TCGGCGCCGGCGGCCAAAGTCAGTAAAAAGGAGCTCAACTCCAACCACGACGGGGCCGACGAGACCTCAGGTCTCACCAACGGCTTTGGG
GGTGCGAGGAGCGAGCAGGAGCCGGGCGGCGGCCTGGGGAGGAAGGCCACACCCCGACGACGCTGTGCCTCCGAGTCCAGCATCTCCTCC
AGCAACAGCCCGCTCTGCGACTCGAGCTTTAATGCGCCCAAATGTGGGCGGGGCAAACCGGCTCTTGTGCGACGGCACACGCTGGAGGAC
CGCAGTGAGCTGATCTCCTGCATCGAGAATGGGAACTACGCCAAGGCGGCCAGGATCGCAGCCGAAGTCGGCCAGAGCAGCATGTGGATC
TCCACTGATGCCGCCGCCTCGGTGCTGGAGCCTCTGAAGGTGGTGTGGGCCAAGTGCAGCGGCTACCCCTCCTACCCGGCACTGATCATC
GACCCCAAGATGCCCCGTGTGCCTGGCCACCACAACGGCGTCACCATCCCGGCCCCACCCCTGGACGTGCTGAAGATTGGGGAGCACATG
CAGACCAAGTCTGATGAGAAGCTGTTCCTCGTTCTCTTTTTTGATAATAAGAGAAGTTGGCAGTGGCTTCCTAAGTCCAAAATGGTTCCC
CTTGGTATTGACGAAACTATAGACAAGTTAAAGATGATGGAAGGGAGGAATTCCAGCATCCGGAAGGCCGTGCGGATCGCTTTTGACCGC
GCCATGAACCACCTGAGCCGCGTCCACGGGGAGCCGACCAGCGACCTCAGTGACATTGACTGACGGCCCGGCCGCCAGCGCGGGTCTTGT
CCATAGTGTTGATAAGCTGTACATGTTTGTATATTGTTCAAAACTTAACTTATTCTGATTTTTAGTTATAGCTCTTTAATTCTTTTTCCC
CGGGGAGGGGGGAGGTTTTATTTCCAAGTTTTCTAGGAACCCATCTCCGTCTGGGCGCTGTGAGTGGGGTGGGCACGTCCGGGCAGCCCA
GTGCGTCTGTCGCACGTCCCCAGGCCGTGCTGCTGGCGTCACTTTCTTTGATATGTAGCTTTTTCTTAAAGACTTTTGAATGTTTAATAA
TTTTGTAAATCATGCTCTTTACACAGAGTACCACTTATTTAATAAGACGGGATGTAAATTTACAATGACAAATGTGTATTTTAAGAAAGA
AAATGACATTATTTTGAATGGTACTTTGTGGAAAGAGGGGAGAATAAAGTTATGCTGTGTACATCACTTGCAGATCACCAAAAACACTCC
GCTGCCCGTGACCGCCGGTGGGTGTGTCCCCGCTCCCGTCGTCCCGCCCACCTCAAACCCCGCAGGTGTGCCTCCCAGCGGATTATTTAT
TGTAGAAAGTGTATTCATTTGCTTTATAATGAAAAATACATTTGCAAAGGTATATTGATATGCATTTTTATACAGGCACATAAAAATTCA
ACTTGGCTTGGGAGCAGAATGCATTGCATTGTATAAATGACTCTGGCCTGTGTGTACTTTGATTTTATAACTTGTAATCTTTTGTTTACA
ATGAGGGGCTTTCTGTAACTTGTTTTAATTTAGAACACTTTGGTAGCAATAGAAACTTTGGATACATTTTTGTATGGTACCTGTGATGTA
TATAGAATTAGTACTTTATTTTTATTTTTAAGAGGTAAAGCATTATGTTGGGGAAAGTAGGGTGGGTTTCCAAATTTGCATTTTTTATAT

>80856_80856_1_SET-BRD1_SET_chr9_131451934_ENST00000322030_BRD1_chr22_50171461_ENST00000216267_length(amino acids)=261AA_BP=24
MSAPAAKVSKKELNSNHDGADETSGLTNGFGGARSEQEPGGGLGRKATPRRRCASESSISSSNSPLCDSSFNAPKCGRGKPALVRRHTLE
DRSELISCIENGNYAKAARIAAEVGQSSMWISTDAAASVLEPLKVVWAKCSGYPSYPALIIDPKMPRVPGHHNGVTIPAPPLDVLKIGEH

--------------------------------------------------------------
>80856_80856_2_SET-BRD1_SET_chr9_131451934_ENST00000322030_BRD1_chr22_50171461_ENST00000342989_length(transcript)=1549nt_BP=430nt
CGCCGTAGGAGGAGGTGGAGGAGGAGGCGGCTCGGGAGAGCGAGCAGCGAGCTGGCTGGATCGCCGAGCGCGAGTGAGGGAGCCGAGCCG
CCCGCCGCCGCCGCCTCCGCCTCCCCTCCGCGAACAGGAGCCCGGGCCGGGGCCCGGCACGCCGCCCCAGCCCGTCCCTCGGCGTCAGGC
CGCGAGGGTAGCGCGCGCGAGCGAGCGAGGGGGAGGGAGAGCGAGCGAGCGCCGGGAGGAGGCGGCCGGACCGAGCGGGCGCCCGCGCGT
GTGGCGTGAGGGGAAGCCGCTTGCCCGCCCCCTTCGCCTTCCCTTCTCTCCCCCTCCCCGCTCCCCCCCCGACCGCGGAGCAGCACCATG
TCGGCGCCGGCGGCCAAAGTCAGTAAAAAGGAGCTCAACTCCAACCACGACGGGGCCGACGAGACCTCAGGTCTCACCAACGGCTTTGGG
GGTGCGAGGAGCGAGCAGGAGCCGGGCGGCGGCCTGGGGAGGAAGGCCACACCCCGACGACGCTGTGCCTCCGAGTCCAGCATCTCCTCC
AGCAACAGCCCGCTCTGCGACTCGAGCTTTAATGCGCCCAAATGTGGGCGGGGCAAACCGGCTCTTGTGCGACGGCACACGCTGGAGGAC
CGCAGTGAGCTGATCTCCTGCATCGAGAATGGGAACTACGCCAAGGCGGCCAGGATCGCAGCCGAAGTCGGCCAGAGCAGCATGTGGATC
TCCACTGATGCCGCCGCCTCGGTGCTGGAGCCTCTGAAGGTGGTGTGGGCCAAGTGCAGCGGCTACCCCTCCTACCCGGCACTGATCATC
GACCCCAAGATGCCCCGTGTGCCTGGCCACCACAACGGCGTCACCATCCCGGCCCCACCCCTGGACGTGCTGAAGATTGGGGAGCACATG
CAGACCAAGTCTGATGAGAAGCTGTTCCTCGTTCTCTTTTTTGATAATAAGAGAAGTTGGCAGTGGCTTCCTAAGTCCAAAATGGTTCCC
CTTGGTATTGACGAAACTATAGACAAGTTAAAGATGATGGAAGGGAGGAATTCCAGCATCCGGAAGGCCGTGCGGATCGCTTTTGACCGC
GCCATGAACCACCTGAGCCGCGTCCACGGGGAGCCGACCAGCGACCTCAGTGACATTGACTGACGGCCCGGCCGCCAGCGCGGGTCTTGT
CCATAGTGTTGATAAGCTGTACATGTTTGTATATTGTTCAAAACTTAACTTATTCTGATTTTTAGTTATAGCTCTTTAATTCTTTTTCCC
CGGGGAGGGGGGAGGTTTTATTTCCAAGTTTTCTAGGAACCCATCTCCGTCTGGGCGCTGTGAGTGGGGTGGGCACGTCCGGGCAGCCCA
GTGCGTCTGTCGCACGTCCCCAGGCCGTGCTGCTGGCGTCACTTTCTTTGATATGTAGCTTTTTCTTAAAGACTTTTGAATGTTTAATAA
TTTTGTAAATCATGCTCTTTACACAGAGTACCACTTATTTAATAAGACGGGATGTAAATTTACAATGACAAATGTGTATTTTAAGAAAGA

>80856_80856_2_SET-BRD1_SET_chr9_131451934_ENST00000322030_BRD1_chr22_50171461_ENST00000342989_length(amino acids)=261AA_BP=24
MSAPAAKVSKKELNSNHDGADETSGLTNGFGGARSEQEPGGGLGRKATPRRRCASESSISSSNSPLCDSSFNAPKCGRGKPALVRRHTLE
DRSELISCIENGNYAKAARIAAEVGQSSMWISTDAAASVLEPLKVVWAKCSGYPSYPALIIDPKMPRVPGHHNGVTIPAPPLDVLKIGEH

--------------------------------------------------------------
>80856_80856_3_SET-BRD1_SET_chr9_131451934_ENST00000322030_BRD1_chr22_50171461_ENST00000404034_length(transcript)=2093nt_BP=430nt
CGCCGTAGGAGGAGGTGGAGGAGGAGGCGGCTCGGGAGAGCGAGCAGCGAGCTGGCTGGATCGCCGAGCGCGAGTGAGGGAGCCGAGCCG
CCCGCCGCCGCCGCCTCCGCCTCCCCTCCGCGAACAGGAGCCCGGGCCGGGGCCCGGCACGCCGCCCCAGCCCGTCCCTCGGCGTCAGGC
CGCGAGGGTAGCGCGCGCGAGCGAGCGAGGGGGAGGGAGAGCGAGCGAGCGCCGGGAGGAGGCGGCCGGACCGAGCGGGCGCCCGCGCGT
GTGGCGTGAGGGGAAGCCGCTTGCCCGCCCCCTTCGCCTTCCCTTCTCTCCCCCTCCCCGCTCCCCCCCCGACCGCGGAGCAGCACCATG
TCGGCGCCGGCGGCCAAAGTCAGTAAAAAGGAGCTCAACTCCAACCACGACGGGGCCGACGAGACCTCAGGTCTCACCAACGGCTTTGGG
GGTGCGAGGAGCGAGCAGGAGCCGGGCGGCGGCCTGGGGAGGAAGGCCACACCCCGACGACGCTGTGCCTCCGAGTCCAGCATCTCCTCC
AGCAACAGCCCGCTCTGCGACTCGAGCTTTAATGCGCCCAAATGTGGGCGGGGCAAACCGGCTCTTGTGCGACGGCACACGCTGGAGGAC
CGCAGTGAGCTGATCTCCTGCATCGAGAATGGGAACTACGCCAAGGCGGCCAGGATCGCAGCCGAAGTCGGCCAGAGCAGCATGTGGATC
TCCACTGATGCCGCCGCCTCGGTGCTGGAGCCTCTGAAGGTGGTGTGGGCCAAGTGCAGCGGCTACCCCTCCTACCCGGCACTGATCATC
GACCCCAAGATGCCCCGTGTGCCTGGCCACCACAACGGCGTCACCATCCCGGCCCCACCCCTGGACGTGCTGAAGATTGGGGAGCACATG
CAGACCAAGTCTGATGAGAAGCTGTTCCTCGTTCTCTTTTTTGATAATAAGAGAAGTTGGCAGTGGCTTCCTAAGTCCAAAATGGTTCCC
CTTGGTATTGACGAAACTATAGACAAGTTAAAGATGATGGAAGGGAGGAATTCCAGCATCCGGAAGGCCGTGCGGATCGCTTTTGACCGC
GCCATGAACCACCTGAGCCGCGTCCACGGGGAGCCGACCAGCGACCTCAGTGACATTGACTGACGGCCCGGCCGCCAGCGCGGGTCTTGT
CCATAGTGTTGATAAGCTGTACATGTTTGTATATTGTTCAAAACTTAACTTATTCTGATTTTTAGTTATAGCTCTTTAATTCTTTTTCCC
CGGGGAGGGGGGAGGTTTTATTTCCAAGTTTTCTAGGAACCCATCTCCGTCTGGGCGCTGTGAGTGGGGTGGGCACGTCCGGGCAGCCCA
GTGCGTCTGTCGCACGTCCCCAGGCCGTGCTGCTGGCGTCACTTTCTTTGATATGTAGCTTTTTCTTAAAGACTTTTGAATGTTTAATAA
TTTTGTAAATCATGCTCTTTACACAGAGTACCACTTATTTAATAAGACGGGATGTAAATTTACAATGACAAATGTGTATTTTAAGAAAGA
AAATGACATTATTTTGAATGGTACTTTGTGGAAAGAGGGGAGAATAAAGTTATGCTGTGTACATCACTTGCAGATCACCAAAAACACTCC
GCTGCCCGTGACCGCCGGTGGGTGTGTCCCCGCTCCCGTCGTCCCGCCCACCTCAAACCCCGCAGGTGTGCCTCCCAGCGGATTATTTAT
TGTAGAAAGTGTATTCATTTGCTTTATAATGAAAAATACATTTGCAAAGGTATATTGATATGCATTTTTATACAGGCACATAAAAATTCA
ACTTGGCTTGGGAGCAGAATGCATTGCATTGTATAAATGACTCTGGCCTGTGTGTACTTTGATTTTATAACTTGTAATCTTTTGTTTACA
ATGAGGGGCTTTCTGTAACTTGTTTTAATTTAGAACACTTTGGTAGCAATAGAAACTTTGGATACATTTTTGTATGGTACCTGTGATGTA
TATAGAATTAGTACTTTATTTTTATTTTTAAGAGGTAAAGCATTATGTTGGGGAAAGTAGGGTGGGTTTCCAAATTTGCATTTTTTATAT

>80856_80856_3_SET-BRD1_SET_chr9_131451934_ENST00000322030_BRD1_chr22_50171461_ENST00000404034_length(amino acids)=261AA_BP=24
MSAPAAKVSKKELNSNHDGADETSGLTNGFGGARSEQEPGGGLGRKATPRRRCASESSISSSNSPLCDSSFNAPKCGRGKPALVRRHTLE
DRSELISCIENGNYAKAARIAAEVGQSSMWISTDAAASVLEPLKVVWAKCSGYPSYPALIIDPKMPRVPGHHNGVTIPAPPLDVLKIGEH

--------------------------------------------------------------
>80856_80856_4_SET-BRD1_SET_chr9_131451934_ENST00000322030_BRD1_chr22_50171461_ENST00000404760_length(transcript)=2093nt_BP=430nt
CGCCGTAGGAGGAGGTGGAGGAGGAGGCGGCTCGGGAGAGCGAGCAGCGAGCTGGCTGGATCGCCGAGCGCGAGTGAGGGAGCCGAGCCG
CCCGCCGCCGCCGCCTCCGCCTCCCCTCCGCGAACAGGAGCCCGGGCCGGGGCCCGGCACGCCGCCCCAGCCCGTCCCTCGGCGTCAGGC
CGCGAGGGTAGCGCGCGCGAGCGAGCGAGGGGGAGGGAGAGCGAGCGAGCGCCGGGAGGAGGCGGCCGGACCGAGCGGGCGCCCGCGCGT
GTGGCGTGAGGGGAAGCCGCTTGCCCGCCCCCTTCGCCTTCCCTTCTCTCCCCCTCCCCGCTCCCCCCCCGACCGCGGAGCAGCACCATG
TCGGCGCCGGCGGCCAAAGTCAGTAAAAAGGAGCTCAACTCCAACCACGACGGGGCCGACGAGACCTCAGGTCTCACCAACGGCTTTGGG
GGTGCGAGGAGCGAGCAGGAGCCGGGCGGCGGCCTGGGGAGGAAGGCCACACCCCGACGACGCTGTGCCTCCGAGTCCAGCATCTCCTCC
AGCAACAGCCCGCTCTGCGACTCGAGCTTTAATGCGCCCAAATGTGGGCGGGGCAAACCGGCTCTTGTGCGACGGCACACGCTGGAGGAC
CGCAGTGAGCTGATCTCCTGCATCGAGAATGGGAACTACGCCAAGGCGGCCAGGATCGCAGCCGAAGTCGGCCAGAGCAGCATGTGGATC
TCCACTGATGCCGCCGCCTCGGTGCTGGAGCCTCTGAAGGTGGTGTGGGCCAAGTGCAGCGGCTACCCCTCCTACCCGGCACTGATCATC
GACCCCAAGATGCCCCGTGTGCCTGGCCACCACAACGGCGTCACCATCCCGGCCCCACCCCTGGACGTGCTGAAGATTGGGGAGCACATG
CAGACCAAGTCTGATGAGAAGCTGTTCCTCGTTCTCTTTTTTGATAATAAGAGAAGTTGGCAGTGGCTTCCTAAGTCCAAAATGGTTCCC
CTTGGTATTGACGAAACTATAGACAAGTTAAAGATGATGGAAGGGAGGAATTCCAGCATCCGGAAGGCCGTGCGGATCGCTTTTGACCGC
GCCATGAACCACCTGAGCCGCGTCCACGGGGAGCCGACCAGCGACCTCAGTGACATTGACTGACGGCCCGGCCGCCAGCGCGGGTCTTGT
CCATAGTGTTGATAAGCTGTACATGTTTGTATATTGTTCAAAACTTAACTTATTCTGATTTTTAGTTATAGCTCTTTAATTCTTTTTCCC
CGGGGAGGGGGGAGGTTTTATTTCCAAGTTTTCTAGGAACCCATCTCCGTCTGGGCGCTGTGAGTGGGGTGGGCACGTCCGGGCAGCCCA
GTGCGTCTGTCGCACGTCCCCAGGCCGTGCTGCTGGCGTCACTTTCTTTGATATGTAGCTTTTTCTTAAAGACTTTTGAATGTTTAATAA
TTTTGTAAATCATGCTCTTTACACAGAGTACCACTTATTTAATAAGACGGGATGTAAATTTACAATGACAAATGTGTATTTTAAGAAAGA
AAATGACATTATTTTGAATGGTACTTTGTGGAAAGAGGGGAGAATAAAGTTATGCTGTGTACATCACTTGCAGATCACCAAAAACACTCC
GCTGCCCGTGACCGCCGGTGGGTGTGTCCCCGCTCCCGTCGTCCCGCCCACCTCAAACCCCGCAGGTGTGCCTCCCAGCGGATTATTTAT
TGTAGAAAGTGTATTCATTTGCTTTATAATGAAAAATACATTTGCAAAGGTATATTGATATGCATTTTTATACAGGCACATAAAAATTCA
ACTTGGCTTGGGAGCAGAATGCATTGCATTGTATAAATGACTCTGGCCTGTGTGTACTTTGATTTTATAACTTGTAATCTTTTGTTTACA
ATGAGGGGCTTTCTGTAACTTGTTTTAATTTAGAACACTTTGGTAGCAATAGAAACTTTGGATACATTTTTGTATGGTACCTGTGATGTA
TATAGAATTAGTACTTTATTTTTATTTTTAAGAGGTAAAGCATTATGTTGGGGAAAGTAGGGTGGGTTTCCAAATTTGCATTTTTTATAT

>80856_80856_4_SET-BRD1_SET_chr9_131451934_ENST00000322030_BRD1_chr22_50171461_ENST00000404760_length(amino acids)=261AA_BP=24
MSAPAAKVSKKELNSNHDGADETSGLTNGFGGARSEQEPGGGLGRKATPRRRCASESSISSSNSPLCDSSFNAPKCGRGKPALVRRHTLE
DRSELISCIENGNYAKAARIAAEVGQSSMWISTDAAASVLEPLKVVWAKCSGYPSYPALIIDPKMPRVPGHHNGVTIPAPPLDVLKIGEH

--------------------------------------------------------------
>80856_80856_5_SET-BRD1_SET_chr9_131451934_ENST00000322030_BRD1_chr22_50171461_ENST00000542442_length(transcript)=1558nt_BP=430nt
CGCCGTAGGAGGAGGTGGAGGAGGAGGCGGCTCGGGAGAGCGAGCAGCGAGCTGGCTGGATCGCCGAGCGCGAGTGAGGGAGCCGAGCCG
CCCGCCGCCGCCGCCTCCGCCTCCCCTCCGCGAACAGGAGCCCGGGCCGGGGCCCGGCACGCCGCCCCAGCCCGTCCCTCGGCGTCAGGC
CGCGAGGGTAGCGCGCGCGAGCGAGCGAGGGGGAGGGAGAGCGAGCGAGCGCCGGGAGGAGGCGGCCGGACCGAGCGGGCGCCCGCGCGT
GTGGCGTGAGGGGAAGCCGCTTGCCCGCCCCCTTCGCCTTCCCTTCTCTCCCCCTCCCCGCTCCCCCCCCGACCGCGGAGCAGCACCATG
TCGGCGCCGGCGGCCAAAGTCAGTAAAAAGGAGCTCAACTCCAACCACGACGGGGCCGACGAGACCTCAGGTCTCACCAACGGCTTTGGG
GGTGCGAGGAGCGAGCAGGAGCCGGGCGGCGGCCTGGGGAGGAAGGCCACACCCCGACGACGCTGTGCCTCCGAGTCCAGCATCTCCTCC
AGCAACAGCCCGCTCTGCGACTCGAGCTTTAATGCGCCCAAATGTGGGCGGGGCAAACCGGCTCTTGTGCGACGGCACACGCTGGAGGAC
CGCAGTGAGCTGATCTCCTGCATCGAGAATGGGAACTACGCCAAGGCGGCCAGGATCGCAGCCGAAGTCGGCCAGAGCAGCATGTGGATC
TCCACTGATGCCGCCGCCTCGGTGCTGGAGCCTCTGAAGGTGGTGTGGGCCAAGTGCAGCGGCTACCCCTCCTACCCGGCACTGATCATC
GACCCCAAGATGCCCCGTGTGCCTGGCCACCACAACGGCGTCACCATCCCGGCCCCACCCCTGGACGTGCTGAAGATTGGGGAGCACATG
CAGACCAAGTCTGATGAGAAGCTGTTCCTCGTTCTCTTTTTTGATAATAAGAGAAGTTGGCAGTGGCTTCCTAAGTCCAAAATGGTTCCC
CTTGGTATTGACGAAACTATAGACAAGTTAAAGATGATGGAAGGGAGGAATTCCAGCATCCGGAAGGCCGTGCGGATCGCTTTTGACCGC
GCCATGAACCACCTGAGCCGCGTCCACGGGGAGCCGACCAGCGACCTCAGTGACATTGACTGACGGCCCGGCCGCCAGCGCGGGTCTTGT
CCATAGTGTTGATAAGCTGTACATGTTTGTATATTGTTCAAAACTTAACTTATTCTGATTTTTAGTTATAGCTCTTTAATTCTTTTTCCC
CGGGGAGGGGGGAGGTTTTATTTCCAAGTTTTCTAGGAACCCATCTCCGTCTGGGCGCTGTGAGTGGGGTGGGCACGTCCGGGCAGCCCA
GTGCGTCTGTCGCACGTCCCCAGGCCGTGCTGCTGGCGTCACTTTCTTTGATATGTAGCTTTTTCTTAAAGACTTTTGAATGTTTAATAA
TTTTGTAAATCATGCTCTTTACACAGAGTACCACTTATTTAATAAGACGGGATGTAAATTTACAATGACAAATGTGTATTTTAAGAAAGA

>80856_80856_5_SET-BRD1_SET_chr9_131451934_ENST00000322030_BRD1_chr22_50171461_ENST00000542442_length(amino acids)=261AA_BP=24
MSAPAAKVSKKELNSNHDGADETSGLTNGFGGARSEQEPGGGLGRKATPRRRCASESSISSSNSPLCDSSFNAPKCGRGKPALVRRHTLE
DRSELISCIENGNYAKAARIAAEVGQSSMWISTDAAASVLEPLKVVWAKCSGYPSYPALIIDPKMPRVPGHHNGVTIPAPPLDVLKIGEH

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SET-BRD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneBRD1chr9:131451934chr22:50171461ENST0000021626761231_80821.33333333333341059.0KAT7/HBO1 and histones
TgeneBRD1chr9:131451934chr22:50171461ENST0000040403471331_80821.33333333333341059.0KAT7/HBO1 and histones
TgeneBRD1chr9:131451934chr22:50171461ENST0000040476071331_80952.33333333333341190.0KAT7/HBO1 and histones


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SET-BRD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SET-BRD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource