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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SETD2-RNF216 (FusionGDB2 ID:80884)

Fusion Gene Summary for SETD2-RNF216

check button Fusion gene summary
Fusion gene informationFusion gene name: SETD2-RNF216
Fusion gene ID: 80884
HgeneTgene
Gene symbol

SETD2

RNF216

Gene ID

29072

54476

Gene nameSET domain containing 2, histone lysine methyltransferasering finger protein 216
SynonymsHBP231|HIF-1|HIP-1|HSPC069|HYPB|KMT3A|LLS|SET2|p231HBPCAHH|TRIAD3|U7I1|UBCE7IP1|ZIN
Cytomap

3p21.31

7p22.1

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase SETD2SET domain containing 2huntingtin interacting protein 1huntingtin yeast partner Bhuntingtin-interacting protein Blysine N-methyltransferase 3Aprotein-lysine N-methyltransferase SETD2E3 ubiquitin-protein ligase RNF216RING-type E3 ubiquitin transferase RNF216triad domain-containing protein 3ubiquitin-conjugating enzyme 7-interacting protein 1zinc finger protein inhibiting NF-kappa-B
Modification date2020031520200313
UniProtAcc.

Q9NWF9

Ensembl transtripts involved in fusion geneENST00000409792, ENST00000492397, 
ENST00000469375, ENST00000389902, 
ENST00000425013, 
Fusion gene scores* DoF score27 X 19 X 16=820817 X 18 X 11=3366
# samples 4133
** MAII scorelog2(41/8208*10)=-4.32333491610161
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(33/3366*10)=-3.35049724708413
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SETD2 [Title/Abstract] AND RNF216 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSETD2(47125209)-RNF216(5756397), # samples:1
SETD2(47125210)-RNF216(5756397), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSETD2

GO:0010569

regulation of double-strand break repair via homologous recombination

24843002

HgeneSETD2

GO:0018023

peptidyl-lysine trimethylation

27518565

HgeneSETD2

GO:0018026

peptidyl-lysine monomethylation

28753426

HgeneSETD2

GO:0032465

regulation of cytokinesis

27518565

HgeneSETD2

GO:0032727

positive regulation of interferon-alpha production

28753426

HgeneSETD2

GO:0034340

response to type I interferon

28753426

HgeneSETD2

GO:0051607

defense response to virus

28753426

HgeneSETD2

GO:0097198

histone H3-K36 trimethylation

23043551|24843002|26002201|27474439|28753426

HgeneSETD2

GO:0097676

histone H3-K36 dimethylation

26002201

HgeneSETD2

GO:1902850

microtubule cytoskeleton organization involved in mitosis

27518565

HgeneSETD2

GO:1905634

regulation of protein localization to chromatin

24843002

TgeneRNF216

GO:0032648

regulation of interferon-beta production

19893624

TgeneRNF216

GO:0043161

proteasome-mediated ubiquitin-dependent protein catabolic process

19893624

TgeneRNF216

GO:0050691

regulation of defense response to virus by host

19893624

TgeneRNF216

GO:0070936

protein K48-linked ubiquitination

19893624


check buttonFusion gene breakpoints across SETD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RNF216 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-8210-01ASETD2chr3

47125210

-RNF216chr7

5756397

-
ChimerDB4STADTCGA-FP-8210SETD2chr3

47125209

-RNF216chr7

5756397

-


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Fusion Gene ORF analysis for SETD2-RNF216

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000409792ENST00000469375SETD2chr3

47125210

-RNF216chr7

5756397

-
5CDS-intronENST00000409792ENST00000469375SETD2chr3

47125209

-RNF216chr7

5756397

-
5UTR-3CDSENST00000492397ENST00000389902SETD2chr3

47125210

-RNF216chr7

5756397

-
5UTR-3CDSENST00000492397ENST00000389902SETD2chr3

47125209

-RNF216chr7

5756397

-
5UTR-3CDSENST00000492397ENST00000425013SETD2chr3

47125210

-RNF216chr7

5756397

-
5UTR-3CDSENST00000492397ENST00000425013SETD2chr3

47125209

-RNF216chr7

5756397

-
5UTR-intronENST00000492397ENST00000469375SETD2chr3

47125210

-RNF216chr7

5756397

-
5UTR-intronENST00000492397ENST00000469375SETD2chr3

47125209

-RNF216chr7

5756397

-
In-frameENST00000409792ENST00000389902SETD2chr3

47125210

-RNF216chr7

5756397

-
In-frameENST00000409792ENST00000389902SETD2chr3

47125209

-RNF216chr7

5756397

-
In-frameENST00000409792ENST00000425013SETD2chr3

47125210

-RNF216chr7

5756397

-
In-frameENST00000409792ENST00000425013SETD2chr3

47125209

-RNF216chr7

5756397

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000409792SETD2chr347125209-ENST00000425013RNF216chr75756397-100446103172302409
ENST00000409792SETD2chr347125209-ENST00000389902RNF216chr75756397-74846103172302409
ENST00000409792SETD2chr347125210-ENST00000425013RNF216chr75756397-100446103172302409
ENST00000409792SETD2chr347125210-ENST00000389902RNF216chr75756397-74846103172302409

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000409792ENST00000425013SETD2chr347125209-RNF216chr75756397-0.0003706480.9996294
ENST00000409792ENST00000389902SETD2chr347125209-RNF216chr75756397-0.0002686610.99973136
ENST00000409792ENST00000425013SETD2chr347125210-RNF216chr75756397-0.0003706480.9996294
ENST00000409792ENST00000389902SETD2chr347125210-RNF216chr75756397-0.0002686610.99973136

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Fusion Genomic Features for SETD2-RNF216


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SETD2-RNF216


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:47125209/chr7:5756397)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RNF216

Q9NWF9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3 inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. {ECO:0000269|PubMed:15107846, ECO:0000269|PubMed:19893624}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-1221166_24720202565.0Compositional biasNote=Pro-rich
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-1221385_45620202565.0Compositional biasNote=Arg-rich
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-1221166_24720202565.0Compositional biasNote=Pro-rich
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-1221385_45620202565.0Compositional biasNote=Arg-rich
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12211494_154820202565.0DomainAWS
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12211550_166720202565.0DomainSET
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12211674_169020202565.0DomainPost-SET
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12211494_154820202565.0DomainAWS
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12211550_166720202565.0DomainSET
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12211674_169020202565.0DomainPost-SET
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12211560_156220202565.0RegionS-adenosyl-L-methionine binding
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12211603_160520202565.0RegionS-adenosyl-L-methionine binding
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12211628_162920202565.0RegionS-adenosyl-L-methionine binding
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12211560_156220202565.0RegionS-adenosyl-L-methionine binding
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12211603_160520202565.0RegionS-adenosyl-L-methionine binding
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12211628_162920202565.0RegionS-adenosyl-L-methionine binding
TgeneRNF216chr3:47125209chr7:5756397ENST00000389902817737_763548924.0Coiled coilOntology_term=ECO:0000255
TgeneRNF216chr3:47125209chr7:5756397ENST00000425013817737_763491867.0Coiled coilOntology_term=ECO:0000255
TgeneRNF216chr3:47125210chr7:5756397ENST00000389902817737_763548924.0Coiled coilOntology_term=ECO:0000255
TgeneRNF216chr3:47125210chr7:5756397ENST00000425013817737_763491867.0Coiled coilOntology_term=ECO:0000255
TgeneRNF216chr3:47125209chr7:5756397ENST00000389902817769_862548924.0Compositional biasNote=Pro-rich
TgeneRNF216chr3:47125209chr7:5756397ENST00000425013817769_862491867.0Compositional biasNote=Pro-rich
TgeneRNF216chr3:47125210chr7:5756397ENST00000389902817769_862548924.0Compositional biasNote=Pro-rich
TgeneRNF216chr3:47125210chr7:5756397ENST00000425013817769_862491867.0Compositional biasNote=Pro-rich
TgeneRNF216chr3:47125209chr7:5756397ENST00000425013817511_728491867.0RegionTRIAD supradomain
TgeneRNF216chr3:47125210chr7:5756397ENST00000425013817511_728491867.0RegionTRIAD supradomain
TgeneRNF216chr3:47125209chr7:5756397ENST00000389902817583_648548924.0Zinc fingerIBR-type
TgeneRNF216chr3:47125209chr7:5756397ENST00000389902817675_703548924.0Zinc fingerRING-type 2%3B atypical
TgeneRNF216chr3:47125209chr7:5756397ENST00000425013817515_564491867.0Zinc fingerRING-type 1
TgeneRNF216chr3:47125209chr7:5756397ENST00000425013817583_648491867.0Zinc fingerIBR-type
TgeneRNF216chr3:47125209chr7:5756397ENST00000425013817675_703491867.0Zinc fingerRING-type 2%3B atypical
TgeneRNF216chr3:47125210chr7:5756397ENST00000389902817583_648548924.0Zinc fingerIBR-type
TgeneRNF216chr3:47125210chr7:5756397ENST00000389902817675_703548924.0Zinc fingerRING-type 2%3B atypical
TgeneRNF216chr3:47125210chr7:5756397ENST00000425013817515_564491867.0Zinc fingerRING-type 1
TgeneRNF216chr3:47125210chr7:5756397ENST00000425013817583_648491867.0Zinc fingerIBR-type
TgeneRNF216chr3:47125210chr7:5756397ENST00000425013817675_703491867.0Zinc fingerRING-type 2%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12212117_214620202565.0Coiled coilOntology_term=ECO:0000255
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12212117_214620202565.0Coiled coilOntology_term=ECO:0000255
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12212149_223220202565.0Compositional biasNote=Pro-rich
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12212266_236520202565.0Compositional biasNote=Gln-rich
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12212149_223220202565.0Compositional biasNote=Pro-rich
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12212266_236520202565.0Compositional biasNote=Gln-rich
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12212389_242220202565.0DomainWW
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12212389_242220202565.0DomainWW
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12212137_236620202565.0RegionLow charge region
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12212137_236620202565.0RegionLow charge region
TgeneRNF216chr3:47125209chr7:5756397ENST00000389902817475_491548924.0Coiled coilOntology_term=ECO:0000255
TgeneRNF216chr3:47125209chr7:5756397ENST00000425013817475_491491867.0Coiled coilOntology_term=ECO:0000255
TgeneRNF216chr3:47125210chr7:5756397ENST00000389902817475_491548924.0Coiled coilOntology_term=ECO:0000255
TgeneRNF216chr3:47125210chr7:5756397ENST00000425013817475_491491867.0Coiled coilOntology_term=ECO:0000255
TgeneRNF216chr3:47125209chr7:5756397ENST00000389902817511_728548924.0RegionTRIAD supradomain
TgeneRNF216chr3:47125210chr7:5756397ENST00000389902817511_728548924.0RegionTRIAD supradomain
TgeneRNF216chr3:47125209chr7:5756397ENST00000389902817515_564548924.0Zinc fingerRING-type 1
TgeneRNF216chr3:47125210chr7:5756397ENST00000389902817515_564548924.0Zinc fingerRING-type 1


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Fusion Gene Sequence for SETD2-RNF216


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>80884_80884_1_SETD2-RNF216_SETD2_chr3_47125209_ENST00000409792_RNF216_chr7_5756397_ENST00000389902_length(transcript)=7484nt_BP=6103nt
GCTGCGGGGAGGGGGCTCGCGTCGCCGTCTCCAGCCGCTCCCGATGAAGCAGCTGCAGCCGCAGCCGCCTCCGAAGATGGGGGATTTCTA
CGACCCGGAGCACCCGACCCCTGAAGAAGAAGAAAATGAGGCAAAGATTGAAAATGTGCAGAAAACAGGTTTCATCAAAGGACCAATGTT
CAAAGGTGTTGCTTCTAGTCGATTTTTGCCCAAAGGCACCAAAACAAAAGTTAATTTGGAAGAACAGGGACGACAGAAGGTGTCATTCAG
CTTCAGCCTTACAAAGAAAACTTTGCAGAATAGGTTTCTCACTGCACTTGGCAATGAAAAGCAAAGTGATACTCCAAACCCTCCAGCTGT
ACCTCTTCAGGTAGACTCGACTCCTAAAATGAAAATGGAAATTGGTGATACCTTATCTACTGCAGAAGAATCTTCCCCACCAAAGTCAAG
GGTGGAATTGGGCAAAATTCATTTTAAGAAACATCTGCTTCATGTAACATCCAGGCCACTGCTGGCTACTACCACAGCAGTAGCATCTCC
ACCTACTCATGCAGCACCATTACCAGCAGTGATAGCAGAATCAACAACTGTAGACTCACCGCCCTCATCTCCGCCTCCACCGCCTCCACC
TGCCCAAGCCACAACACTCTCATCACCAGCACCAGTAACAGAGCCAGTGGCCTTGCCACATACACCAATAACAGTTCTAATGGCAGCACC
AGTACCCTTACCAGTAGATGTAGCAGTTAGATCTCTGAAAGAACCACCAATTATAATTGTACCAGAATCTTTAGAAGCAGATACTAAGCA
GGACACTATATCTAATAGTTTAGAAGAACACGTAACTCAAATATTGAATGAGCAAGCAGATATTTCCTCAAAAAAAGAAGATTCCCATAT
TGGGAAGGATGAAGAAATTCCAGATAGTTCTAAGATTAGTCTGAGCTGTAAAAAAACAGGTTCTAAGAAGAAATCCTCACAATCTGAAGG
CATCTTTCTTGGTTCAGAATCTGATGAAGATTCTGTACGGACTTCTTCAAGTCAAAGATCACATGATTTAAAATTTTCAGCAAGCATTGA
AAAGGAAAGAGATTTTAAAAAGAGCTCAGCACCTTTAAAAAGTGAGGATCTAGGGAAACCTTCACGATCTAAAACAGACAGAGATGATAA
ATATTTTAGCTATTCAAAACTTGAAAGAGATACTCGGTATGTATCTTCCCGATGTAGATCAGAAAGAGAGCGACGGCGGAGCAGATCTCA
CTCTAGGTCTGAGAGAGGCTCTAGAACTAATTTATCCTATTCCAGGTCAGAACGATCTCATTATTATGACTCTGATCGTCGCTACCATAG
GAGCTCCCCTTATCGAGAGAGGACGCGCTATTCTCGGCCATACACAGATAACAGAGCACGAGAGAGTTCTGACTCAGAAGAAGAGTATAA
GAAGACATACTCAAGGCGTACCTCATCTCATTCCTCTTCTTACAGAGACCTAAGGACATCATCCTATTCTAAATCTGATCGGGACTGTAA
AACTGAGACCTCTTACTTAGAGATGGAAAGAAGAGGCAAGTATTCTTCAAAACTAGAAAGAGAATCTAAAAGGACTTCAGAAAATGAAGC
AATTAAAAGATGTTGTTCTCCCCCTAATGAACTGGGATTCCGACGAGGGTCATCATATTCTAAGCATGACAGTAGTGCTTCCCGTTATAA
ATCTACCCTTTCAAAACCTATACCCAAGTCTGATAAATTTAAAAATTCTTTCTGTTGTACAGAATTAAATGAAGAAATCAAACAGTCTCA
TTCTTTTAGTTTACAGACACCTTGTTCAAAAGGTAGTGAATTAAGAATGATTAATAAAAATCCTGAAAGAGAAAAGGCTGGGTCTCCAGC
TCCATCAAATCGATTAAATGATTCACCTACTTTAAAAAAGCTAGATGAATTGCCTATTTTTAAGTCCGAATTTATAACACATGATAGCCA
TGATAGTATTAAGGAATTAGACTCTTTATCTAAAGTGAAGAATGATCAATTAAGAAGTTTTTGTCCCATAGAATTAAATATAAATGGATC
TCCTGGGGCAGAATCTGATTTGGCAACATTTTGCACTTCTAAAACTGATGCTGTTTTAATGACTTCTGATGATAGTGTGACTGGATCGGA
ATTATCCCCTTTGGTCAAAGCATGCATGCTTTCATCAAATGGATTTCAGAATATTAGTAGGTGCAAAGAAAAAGACTTGGATGATACCTG
CATGCTGCATAAGAAGTCAGAAAGCCCATTTAGAGAAACAGAACCTCTGGTGTCACCACACCAAGATAAACTCATGTCTATGCCAGTTAT
GACTGTGGATTATTCCAAAACAGTAGTTAAAGAACCAGTTGATACGAGGGTTTCTTGCTGCAAAACCAAAGATTCAGACATATACTGTAC
TTTGAACGATAGCAACCCTTCTTTGTGTAACTCTGAAGCTGAAAATATTGAGCCTTCAGTTATGAAGATTTCTTCAAATAGCTTTATGAA
TGTGCATTTGGAATCAAAACCAGTTATATGTGATAGTAGAAATTTGACAGATCACTCAAAATTTGCATGTGAAGAATATAAGCAGAGCAT
CGGTAGCACTAGTTCAGCTTCTGTTAATCATTTTGATGATTTATATCAACCTATTGGGAGTTCAGGTATTGCTTCATCTCTTCAGAGTCT
TCCACCAGGAATAAAGGTGGACAGTCTAACTCTCTTGAAATGCGGAGAGAACACATCTCCAGTTCTGGATGCAGTGCTAAAGAGTAAAAA
AAGTTCAGAGTTTTTAAAGCATGCAGGGAAAGAAACAATAGTAGAAGTAGGTAGTGACCTTCCTGATTCAGGAAAGGGATTTGCTTCCAG
GGAGAACAGGCGTAATAATGGGTTATCTGGGAAATGTTTGCAAGAGGCTCAAGAAGAAGGGAATTCCATATTGCCTGAAAGAAGAGGAAG
ACCAGAAATCTCTTTAGATGAAAGAGGAGAAGGAGGACATGTGCATACTTCTGATGACTCAGAAGTTGTATTTTCTTCTTGTGATTTGAA
TTTAACCATGGAAGACAGTGATGGTGTAACTTATGCATTAAAGTGTGACAGTAGTGGTCATGCCCCAGAAATTGTGTCTACAGTTCATGA
AGATTATTCTGGCTCTTCTGAAAGTTCAAATGATGAAAGTGATTCAGAAGATACAGATTCGGATGATAGCAGTATTCCAAGAAACCGTCT
CCAGTCTGTTGTGGTTGTGCCAAAGAATTCTACTTTGCCCATGGAAGAAACAAGTCCTTGTTCTTCTCGGAGCAGTCAAAGTTATAGACA
CTATTCTGACCATTGGGAAGATGAGAGATTGGAGTCAAGGAGACATTTGTATGAGGAAAAATTTGAAAGTATAGCAAGTAAAGCCTGTCC
TCAAACTGATAAGTTTTTCCTTCATAAAGGAACAGAGAAGAATCCGGAAATTTCTTTTACACAGTCCAGTAGAAAACAAATAGATAATCG
CCTGCCTGAACTTTCTCATCCTCAGAGTGATGGGGTTGATAGTACAAGTCATACAGATGTGAAATCTGACCCTCTGGGTCACCCAAATTC
AGAGGAAACCGTGAAAGCCAAAATACCTTCTAGGCAGCAAGAAGAGCTGCCAATTTATTCTTCTGATTTTGAAGATGTCCCAAATAAGTC
TTGGCAACAGACCACTTTCCAAAACAGGCCAGATAGTAGACTGGGAAAAACAGAATTGAGTTTTTCTTCCTCTTGTGAGATACCACATGT
GGATGGCTTGCACTCATCAGAAGAGCTCAGAAACTTAGGTTGGGACTTCTCTCAAGAAAAGCCTTCTACCACGTATCAGCAACCTGACAG
TAGCTATGGAGCTTGTGGTGGACACAAGTATCAGCAAAATGCAGAACAGTATGGTGGGACACGTGATTACTGGCAAGGCAATGGTTACTG
GGATCCAAGATCAGGTAGACCTCCTGGAACTGGGGTTGTGTATGATCGAACTCAAGGACAAGTACCAGATTCCCTAACAGATGATCGTGA
AGAAGAGGAGAATTGGGATCAACAGGATGGATCCCATTTTTCAGACCAGTCCGATAAATTTCTTCTATCCCTTCAGAAAGACAAGGGGTC
AGTGCAAGCACCTGAAATAAGCAGCAATTCCATTAAGGACACTTTAGCTGTGAATGAAAAGAAAGATTTTTCAAAAAACTTAGAAAAAAA
TGATATCAAAGATAGAGGGCCTCTTAAAAAAAGGAGGCAGGAAATAGAGAGTGATTCTGAAAGTGATGGTGAGCTTCAGGACAGAAAGAA
AGTTAGAGTGGAGGTAGAGCAGGGAGAGACATCAGTGCCCCCAGGTTCAGCACTGGTTGGGCCCTCCTGTGTCATGGATGACTTCAGGGA
CCCACAGCGATGGAAGGAATGTGCCAAGCAAGGGAAAATGCCATGTTACTTTGATCTTATTGAAGAAAATGTTTATTTAACAGAAAGAAA
GAAGAATAAATCTCATCGAGATATTAAGCGAATGCAGTGTGAGTGTACACCTCTTTCTAAAGATGAAAGAGCTCAAGGTGAAATAGCATG
TGGGGAAGATTGTCTTAATCGTCTTCTCATGATTGAATGTTCTTCTCGGTGTCCAAATGGGGATTATTGTTCCAATAGACGGTTTCAGAG
AAAACAGCATGCAGATGTGGAAGTCATACTCACAGAAAAGAAAGGCTGGGGCTTGAGAGCTGCCAAAGACCTTCCTTCGAACACCTTTGT
CCTAGAATATTGTGGAGAGGTACTCGATCATAAAGAGTTTAAAGCTCGAGTGAAGGAGTATGCACGAAACAAAAACATCCATTACTATTT
CATGGCCCTGAAGAATGATGAGATAATAGATGCCACTCAAAAAGGAAATTGCTCTCGTTTCATGAATCACAGCTGTGAACCAAATTGTGA
AACCCAAAAATGGACTGTGAACGGACAACTGAGGGTTGGGTTTTTTACCACCAAACTGGTTCCTTCAGGCTCAGAGTTAACGTTTGACTA
TCAGTTCCAGAGATATGGAAAAGAAGCCCAGAAATGTTTCTGCGGATCAGCCAATTGCCGGGGTTACCTGGGAGGAGAAAACAGAGTCAG
CATCAGAGCAGCAGGAGGGAAAATGAAGAAGGAACGATCTCGTAAGAAGGATTCAGTGGATGGAGAGCTAGAAGCTCTGATGGAAAATGG
TGAGGGTCTCTCTGATAAAAACCAGGTGCTCAGCTTATCCCGGCTAATGGTTAGAATTGAAACTTTGGAGCAGAAACTTACCTGTCTGGA
ACTCATACAGAACACACACTCACAGTCCTGCCTGAAGTCCTTTCTGGAACGTCATGGGCTGTCTTTGTTGTGGATCTGGATGGCAGAGCT
AGGTGACGGCCGGGAAAGTAACCAGAAGCTTCAGGAAGAGATTATAAAGACTTTGGAACACTTGCCCATTCCTACTAAAAATATGTTGGA
GGAAAGCAAAGTACTTCCAATTATTCAACGCTGGTCTCAGACTAAGACTGCTGTCCCTCCGTTGAGTGAAGGAGATGGGTATTCTAGTGA
GAATACATCGCGTGCTCATACACCACTCAACACACCTGATCCTTCCACCAAGCTGAGCACAGAAGCTGACACAGACACTCCCAAGAAACT
AATGTTTCGCAGACTGAAAATTATAAGTGAAAATAGCATGGACAGTGCAATCTCTGATGCAACCAGTGAGCTAGAAGGCAAGGATGGCAA
AGAGGATCTTGATCAATTAGAAAATGTCCCTGTAGAGGAAGAGGAAGAATTGCAGTCACAACAGCTACTCCCACAACAGCTGCCTGAATG
CAAAGTTGATAGTGAAACCAACATAGAAGCTAGTAAGCTACCTACATCTGAACCAGAAGCTGACGCTGAAATAGAGCCCAAAGAGAGCAA
CGGCACAAAACTAGAAGAACCTATTAATGAAGAAACACCATCCCAAGATGAAGAGGAGGGTGTGTCTGATGTGGAGAGTGAAAGGAGCCA
AGAACAGCCAGATAAAACAGTGGATATAAGTGATTTGGCCACCAAACTCCTGGACAGTTGGAAAGACCTAAAGCATGAAGACTTTTTGCT
TGCCCTACAGATGAATGAAGAACAGTATCAAAAGGATGGCCAGCTGATTGAGTGTCGCTGCTGCTATGGGGAATTTCCATTCGAGGAGCT
GACGCAGTGCGCAGATGCTCACTTGTTCTGCAAAGAGTGTCTCATCAGATATGCCCAAGAGGCAGTCTTTGGATCTGGAAAGTTGGAGCT
CAGCTGCATGGAAGGCAGCTGCACGTGTTCGTTCCCAACCAGTGAGCTGGAGAAGGTGCTCCCCCAGACCATCCTGTATAAGTACTATGA
GCGAAAAGCCGAGGAGGAGGTTGCGGCAGCCTACGCCGACGAGCTTGTCAGGTGCCCGTCCTGTAGCTTTCCGGCTCTGTTGGACAGTGA
TGTGAAGAGGTTCAGCTGTCCTAATCCTCACTGCCGAAAGGAAACCTGTAGGAAGTGTCAGGGACTCTGGAAAGAACATAATGGCCTCAC
CTGTGAAGAGCTGGCTGAAAAAGACGACATCAAGTACCGTACCTCTATTGAAGAAAAAATGACTGCTGCCCGCATTAGAAAATGCCACAA
GTGTGGGACTGGCCTCATCAAATCTGAAGGCTGCAACCGCATGTCTTGCCGCTGTGGTGCCCAGATGTGCTACCTCTGTCGAGTTTCTAT
TAATGGATATGACCATTTCTGCCAACATCCCCGCTCACCAGGAGCCCCTTGCCAGGAGTGTTCAAGATGCTCTCTCTGGACCGATCCCAC
TGAAGATGATGAGAAGCTTATTGAGGAAATCCAGAAGGAGGCTGAAGAGGAACAGAAAAGAAAGAATGGAGAGAACACCTTCAAACGCAT
TGGACCCCCGCTGGAGAAGCCTGTGGAGAAGGTGCAGAGGGTGGAGGCCCTCCCGAGGCCCGTTCCGCAGAACCTGCCACAGCCACAGAT
GCCACCCTATGCCTTCGCGCACCCACCCTTCCCCCTGCCTCCCGTGCGGCCTGTGTTCAACAACTTCCCACTCAACATGGGGCCTATCCC
AGCCCCGTACGTGCCCCCTCTGCCCAACGTGCGGGTCAACTATGACTTCGGTCCCATCCACATGCCCCTGGAGCACAACCTGCCCATGCA
CTTTGGCCCCCAGCCGCGGCATCGCTTCTGATGGCCCCGAATCCCCATTGAGCAGCACAAAGCCCGTTTGGGGTAGGAGTGTGGATGGAG
AACCCTCCCCCAAGGCTGGTGTCTGTACCATTGCATCCTAAGTCAGCTTGAAGGGTAGGCTGGTTTTCTTCCCACCCCTTTCCTAGAAGG
GCTACTGCTCCTGGAAGAGTGGACGGATCCATAATAAAGACGTCCCAAATGGTGGAGTTCGGAGAGAGCTGCGATGTGAACTGCCCCTCC

>80884_80884_1_SETD2-RNF216_SETD2_chr3_47125209_ENST00000409792_RNF216_chr7_5756397_ENST00000389902_length(amino acids)=2409AA_BP=2032
LRGGGSRRRLQPLPMKQLQPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTKTKVNLEEQGRQKVSFS
FSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASP
PTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQ
DTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIE
KERDFKKSSAPLKSEDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHR
SSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEA
IKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPEREKAGSPA
PSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSE
LSPLVKACMLSSNGFQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVDTRVSCCKTKDSDIYCT
LNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRNLTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSL
PPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQEEGNSILPERRGR
PEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRL
QSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKNPEISFTQSSRKQIDNR
LPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQQEELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHV
DGLHSSEELRNLGWDFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPDSLTDDRE
EEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAVNEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKK
VRVEVEQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEIAC
GEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYF
MALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVS
IRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAEL
GDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTEADTDTPKKL
MFRRLKIISENSMDSAISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAEIEPKESN
GTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEEL
TQCADAHLFCKECLIRYAQEAVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSD
VKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSI
NGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEEEQKRKNGENTFKRIGPPLEKPVEKVQRVEALPRPVPQNLPQPQM

--------------------------------------------------------------
>80884_80884_2_SETD2-RNF216_SETD2_chr3_47125209_ENST00000409792_RNF216_chr7_5756397_ENST00000425013_length(transcript)=10044nt_BP=6103nt
GCTGCGGGGAGGGGGCTCGCGTCGCCGTCTCCAGCCGCTCCCGATGAAGCAGCTGCAGCCGCAGCCGCCTCCGAAGATGGGGGATTTCTA
CGACCCGGAGCACCCGACCCCTGAAGAAGAAGAAAATGAGGCAAAGATTGAAAATGTGCAGAAAACAGGTTTCATCAAAGGACCAATGTT
CAAAGGTGTTGCTTCTAGTCGATTTTTGCCCAAAGGCACCAAAACAAAAGTTAATTTGGAAGAACAGGGACGACAGAAGGTGTCATTCAG
CTTCAGCCTTACAAAGAAAACTTTGCAGAATAGGTTTCTCACTGCACTTGGCAATGAAAAGCAAAGTGATACTCCAAACCCTCCAGCTGT
ACCTCTTCAGGTAGACTCGACTCCTAAAATGAAAATGGAAATTGGTGATACCTTATCTACTGCAGAAGAATCTTCCCCACCAAAGTCAAG
GGTGGAATTGGGCAAAATTCATTTTAAGAAACATCTGCTTCATGTAACATCCAGGCCACTGCTGGCTACTACCACAGCAGTAGCATCTCC
ACCTACTCATGCAGCACCATTACCAGCAGTGATAGCAGAATCAACAACTGTAGACTCACCGCCCTCATCTCCGCCTCCACCGCCTCCACC
TGCCCAAGCCACAACACTCTCATCACCAGCACCAGTAACAGAGCCAGTGGCCTTGCCACATACACCAATAACAGTTCTAATGGCAGCACC
AGTACCCTTACCAGTAGATGTAGCAGTTAGATCTCTGAAAGAACCACCAATTATAATTGTACCAGAATCTTTAGAAGCAGATACTAAGCA
GGACACTATATCTAATAGTTTAGAAGAACACGTAACTCAAATATTGAATGAGCAAGCAGATATTTCCTCAAAAAAAGAAGATTCCCATAT
TGGGAAGGATGAAGAAATTCCAGATAGTTCTAAGATTAGTCTGAGCTGTAAAAAAACAGGTTCTAAGAAGAAATCCTCACAATCTGAAGG
CATCTTTCTTGGTTCAGAATCTGATGAAGATTCTGTACGGACTTCTTCAAGTCAAAGATCACATGATTTAAAATTTTCAGCAAGCATTGA
AAAGGAAAGAGATTTTAAAAAGAGCTCAGCACCTTTAAAAAGTGAGGATCTAGGGAAACCTTCACGATCTAAAACAGACAGAGATGATAA
ATATTTTAGCTATTCAAAACTTGAAAGAGATACTCGGTATGTATCTTCCCGATGTAGATCAGAAAGAGAGCGACGGCGGAGCAGATCTCA
CTCTAGGTCTGAGAGAGGCTCTAGAACTAATTTATCCTATTCCAGGTCAGAACGATCTCATTATTATGACTCTGATCGTCGCTACCATAG
GAGCTCCCCTTATCGAGAGAGGACGCGCTATTCTCGGCCATACACAGATAACAGAGCACGAGAGAGTTCTGACTCAGAAGAAGAGTATAA
GAAGACATACTCAAGGCGTACCTCATCTCATTCCTCTTCTTACAGAGACCTAAGGACATCATCCTATTCTAAATCTGATCGGGACTGTAA
AACTGAGACCTCTTACTTAGAGATGGAAAGAAGAGGCAAGTATTCTTCAAAACTAGAAAGAGAATCTAAAAGGACTTCAGAAAATGAAGC
AATTAAAAGATGTTGTTCTCCCCCTAATGAACTGGGATTCCGACGAGGGTCATCATATTCTAAGCATGACAGTAGTGCTTCCCGTTATAA
ATCTACCCTTTCAAAACCTATACCCAAGTCTGATAAATTTAAAAATTCTTTCTGTTGTACAGAATTAAATGAAGAAATCAAACAGTCTCA
TTCTTTTAGTTTACAGACACCTTGTTCAAAAGGTAGTGAATTAAGAATGATTAATAAAAATCCTGAAAGAGAAAAGGCTGGGTCTCCAGC
TCCATCAAATCGATTAAATGATTCACCTACTTTAAAAAAGCTAGATGAATTGCCTATTTTTAAGTCCGAATTTATAACACATGATAGCCA
TGATAGTATTAAGGAATTAGACTCTTTATCTAAAGTGAAGAATGATCAATTAAGAAGTTTTTGTCCCATAGAATTAAATATAAATGGATC
TCCTGGGGCAGAATCTGATTTGGCAACATTTTGCACTTCTAAAACTGATGCTGTTTTAATGACTTCTGATGATAGTGTGACTGGATCGGA
ATTATCCCCTTTGGTCAAAGCATGCATGCTTTCATCAAATGGATTTCAGAATATTAGTAGGTGCAAAGAAAAAGACTTGGATGATACCTG
CATGCTGCATAAGAAGTCAGAAAGCCCATTTAGAGAAACAGAACCTCTGGTGTCACCACACCAAGATAAACTCATGTCTATGCCAGTTAT
GACTGTGGATTATTCCAAAACAGTAGTTAAAGAACCAGTTGATACGAGGGTTTCTTGCTGCAAAACCAAAGATTCAGACATATACTGTAC
TTTGAACGATAGCAACCCTTCTTTGTGTAACTCTGAAGCTGAAAATATTGAGCCTTCAGTTATGAAGATTTCTTCAAATAGCTTTATGAA
TGTGCATTTGGAATCAAAACCAGTTATATGTGATAGTAGAAATTTGACAGATCACTCAAAATTTGCATGTGAAGAATATAAGCAGAGCAT
CGGTAGCACTAGTTCAGCTTCTGTTAATCATTTTGATGATTTATATCAACCTATTGGGAGTTCAGGTATTGCTTCATCTCTTCAGAGTCT
TCCACCAGGAATAAAGGTGGACAGTCTAACTCTCTTGAAATGCGGAGAGAACACATCTCCAGTTCTGGATGCAGTGCTAAAGAGTAAAAA
AAGTTCAGAGTTTTTAAAGCATGCAGGGAAAGAAACAATAGTAGAAGTAGGTAGTGACCTTCCTGATTCAGGAAAGGGATTTGCTTCCAG
GGAGAACAGGCGTAATAATGGGTTATCTGGGAAATGTTTGCAAGAGGCTCAAGAAGAAGGGAATTCCATATTGCCTGAAAGAAGAGGAAG
ACCAGAAATCTCTTTAGATGAAAGAGGAGAAGGAGGACATGTGCATACTTCTGATGACTCAGAAGTTGTATTTTCTTCTTGTGATTTGAA
TTTAACCATGGAAGACAGTGATGGTGTAACTTATGCATTAAAGTGTGACAGTAGTGGTCATGCCCCAGAAATTGTGTCTACAGTTCATGA
AGATTATTCTGGCTCTTCTGAAAGTTCAAATGATGAAAGTGATTCAGAAGATACAGATTCGGATGATAGCAGTATTCCAAGAAACCGTCT
CCAGTCTGTTGTGGTTGTGCCAAAGAATTCTACTTTGCCCATGGAAGAAACAAGTCCTTGTTCTTCTCGGAGCAGTCAAAGTTATAGACA
CTATTCTGACCATTGGGAAGATGAGAGATTGGAGTCAAGGAGACATTTGTATGAGGAAAAATTTGAAAGTATAGCAAGTAAAGCCTGTCC
TCAAACTGATAAGTTTTTCCTTCATAAAGGAACAGAGAAGAATCCGGAAATTTCTTTTACACAGTCCAGTAGAAAACAAATAGATAATCG
CCTGCCTGAACTTTCTCATCCTCAGAGTGATGGGGTTGATAGTACAAGTCATACAGATGTGAAATCTGACCCTCTGGGTCACCCAAATTC
AGAGGAAACCGTGAAAGCCAAAATACCTTCTAGGCAGCAAGAAGAGCTGCCAATTTATTCTTCTGATTTTGAAGATGTCCCAAATAAGTC
TTGGCAACAGACCACTTTCCAAAACAGGCCAGATAGTAGACTGGGAAAAACAGAATTGAGTTTTTCTTCCTCTTGTGAGATACCACATGT
GGATGGCTTGCACTCATCAGAAGAGCTCAGAAACTTAGGTTGGGACTTCTCTCAAGAAAAGCCTTCTACCACGTATCAGCAACCTGACAG
TAGCTATGGAGCTTGTGGTGGACACAAGTATCAGCAAAATGCAGAACAGTATGGTGGGACACGTGATTACTGGCAAGGCAATGGTTACTG
GGATCCAAGATCAGGTAGACCTCCTGGAACTGGGGTTGTGTATGATCGAACTCAAGGACAAGTACCAGATTCCCTAACAGATGATCGTGA
AGAAGAGGAGAATTGGGATCAACAGGATGGATCCCATTTTTCAGACCAGTCCGATAAATTTCTTCTATCCCTTCAGAAAGACAAGGGGTC
AGTGCAAGCACCTGAAATAAGCAGCAATTCCATTAAGGACACTTTAGCTGTGAATGAAAAGAAAGATTTTTCAAAAAACTTAGAAAAAAA
TGATATCAAAGATAGAGGGCCTCTTAAAAAAAGGAGGCAGGAAATAGAGAGTGATTCTGAAAGTGATGGTGAGCTTCAGGACAGAAAGAA
AGTTAGAGTGGAGGTAGAGCAGGGAGAGACATCAGTGCCCCCAGGTTCAGCACTGGTTGGGCCCTCCTGTGTCATGGATGACTTCAGGGA
CCCACAGCGATGGAAGGAATGTGCCAAGCAAGGGAAAATGCCATGTTACTTTGATCTTATTGAAGAAAATGTTTATTTAACAGAAAGAAA
GAAGAATAAATCTCATCGAGATATTAAGCGAATGCAGTGTGAGTGTACACCTCTTTCTAAAGATGAAAGAGCTCAAGGTGAAATAGCATG
TGGGGAAGATTGTCTTAATCGTCTTCTCATGATTGAATGTTCTTCTCGGTGTCCAAATGGGGATTATTGTTCCAATAGACGGTTTCAGAG
AAAACAGCATGCAGATGTGGAAGTCATACTCACAGAAAAGAAAGGCTGGGGCTTGAGAGCTGCCAAAGACCTTCCTTCGAACACCTTTGT
CCTAGAATATTGTGGAGAGGTACTCGATCATAAAGAGTTTAAAGCTCGAGTGAAGGAGTATGCACGAAACAAAAACATCCATTACTATTT
CATGGCCCTGAAGAATGATGAGATAATAGATGCCACTCAAAAAGGAAATTGCTCTCGTTTCATGAATCACAGCTGTGAACCAAATTGTGA
AACCCAAAAATGGACTGTGAACGGACAACTGAGGGTTGGGTTTTTTACCACCAAACTGGTTCCTTCAGGCTCAGAGTTAACGTTTGACTA
TCAGTTCCAGAGATATGGAAAAGAAGCCCAGAAATGTTTCTGCGGATCAGCCAATTGCCGGGGTTACCTGGGAGGAGAAAACAGAGTCAG
CATCAGAGCAGCAGGAGGGAAAATGAAGAAGGAACGATCTCGTAAGAAGGATTCAGTGGATGGAGAGCTAGAAGCTCTGATGGAAAATGG
TGAGGGTCTCTCTGATAAAAACCAGGTGCTCAGCTTATCCCGGCTAATGGTTAGAATTGAAACTTTGGAGCAGAAACTTACCTGTCTGGA
ACTCATACAGAACACACACTCACAGTCCTGCCTGAAGTCCTTTCTGGAACGTCATGGGCTGTCTTTGTTGTGGATCTGGATGGCAGAGCT
AGGTGACGGCCGGGAAAGTAACCAGAAGCTTCAGGAAGAGATTATAAAGACTTTGGAACACTTGCCCATTCCTACTAAAAATATGTTGGA
GGAAAGCAAAGTACTTCCAATTATTCAACGCTGGTCTCAGACTAAGACTGCTGTCCCTCCGTTGAGTGAAGGAGATGGGTATTCTAGTGA
GAATACATCGCGTGCTCATACACCACTCAACACACCTGATCCTTCCACCAAGCTGAGCACAGAAGCTGACACAGACACTCCCAAGAAACT
AATGTTTCGCAGACTGAAAATTATAAGTGAAAATAGCATGGACAGTGCAATCTCTGATGCAACCAGTGAGCTAGAAGGCAAGGATGGCAA
AGAGGATCTTGATCAATTAGAAAATGTCCCTGTAGAGGAAGAGGAAGAATTGCAGTCACAACAGCTACTCCCACAACAGCTGCCTGAATG
CAAAGTTGATAGTGAAACCAACATAGAAGCTAGTAAGCTACCTACATCTGAACCAGAAGCTGACGCTGAAATAGAGCCCAAAGAGAGCAA
CGGCACAAAACTAGAAGAACCTATTAATGAAGAAACACCATCCCAAGATGAAGAGGAGGGTGTGTCTGATGTGGAGAGTGAAAGGAGCCA
AGAACAGCCAGATAAAACAGTGGATATAAGTGATTTGGCCACCAAACTCCTGGACAGTTGGAAAGACCTAAAGCATGAAGACTTTTTGCT
TGCCCTACAGATGAATGAAGAACAGTATCAAAAGGATGGCCAGCTGATTGAGTGTCGCTGCTGCTATGGGGAATTTCCATTCGAGGAGCT
GACGCAGTGCGCAGATGCTCACTTGTTCTGCAAAGAGTGTCTCATCAGATATGCCCAAGAGGCAGTCTTTGGATCTGGAAAGTTGGAGCT
CAGCTGCATGGAAGGCAGCTGCACGTGTTCGTTCCCAACCAGTGAGCTGGAGAAGGTGCTCCCCCAGACCATCCTGTATAAGTACTATGA
GCGAAAAGCCGAGGAGGAGGTTGCGGCAGCCTACGCCGACGAGCTTGTCAGGTGCCCGTCCTGTAGCTTTCCGGCTCTGTTGGACAGTGA
TGTGAAGAGGTTCAGCTGTCCTAATCCTCACTGCCGAAAGGAAACCTGTAGGAAGTGTCAGGGACTCTGGAAAGAACATAATGGCCTCAC
CTGTGAAGAGCTGGCTGAAAAAGACGACATCAAGTACCGTACCTCTATTGAAGAAAAAATGACTGCTGCCCGCATTAGAAAATGCCACAA
GTGTGGGACTGGCCTCATCAAATCTGAAGGCTGCAACCGCATGTCTTGCCGCTGTGGTGCCCAGATGTGCTACCTCTGTCGAGTTTCTAT
TAATGGATATGACCATTTCTGCCAACATCCCCGCTCACCAGGAGCCCCTTGCCAGGAGTGTTCAAGATGCTCTCTCTGGACCGATCCCAC
TGAAGATGATGAGAAGCTTATTGAGGAAATCCAGAAGGAGGCTGAAGAGGAACAGAAAAGAAAGAATGGAGAGAACACCTTCAAACGCAT
TGGACCCCCGCTGGAGAAGCCTGTGGAGAAGGTGCAGAGGGTGGAGGCCCTCCCGAGGCCCGTTCCGCAGAACCTGCCACAGCCACAGAT
GCCACCCTATGCCTTCGCGCACCCACCCTTCCCCCTGCCTCCCGTGCGGCCTGTGTTCAACAACTTCCCACTCAACATGGGGCCTATCCC
AGCCCCGTACGTGCCCCCTCTGCCCAACGTGCGGGTCAACTATGACTTCGGTCCCATCCACATGCCCCTGGAGCACAACCTGCCCATGCA
CTTTGGCCCCCAGCCGCGGCATCGCTTCTGATGGCCCCGAATCCCCATTGAGCAGCACAAAGCCCGTTTGGGGTAGGAGTGTGGATGGAG
AACCCTCCCCCAAGGCTGGTGTCTGTACCATTGCATCCTAAGTCAGCTTGAAGGGTAGGCTGGTTTTCTTCCCACCCCTTTCCTAGAAGG
GCTACTGCTCCTGGAAGAGTGGACGGATCCATAATAAAGACGTCCCAAATGGTGGAGTTCGGAGAGAGCTGCGATGTGAACTGCCCCTCC
CCTCGCATCCCCCAGGCCACCAACGGCAGTCCTTCTGCCTTGTCCATGGCATAGGCCATAGACCAGGTCCCTGCTGCTCACACCTGGGCC
TCTCCTCGGAGCCGACCCCTGGGTAGCAAGGCAGCCGAGAGCATCTCCCTGGAGGGGCCCACGGTTGGGCCAAGGGCAGAGGGGGCTGCA
CCTGCGGGCCTGGGAAGCATTGCTCAGGGTGGGGGGCTGGGACCATGGCCCGCAGAGGCACTGCCACAGCTGTGAGGGCCAAGATGCTGT
CCCCCCATCCAAAACCCGTGCGCCACTGCAGTGAGTGTTGAGGGCACCTCTCCTCCCCTCTTACACCTACTCAGATGAGGCAGCAGCAGA
CCCATCTCGCGGCGGGGGTTTTGTTCTGTTGCCGCCTAACTTTCTCATCCTCGGTCTCTGGAAAGTCAGGCTGAGAAATCCTTTCCCAGG
CCAGGCCGCTGCGGTACACTGGATGGTTCTGAAGCTGGCCCATTGAAAGAGCCTCTTAAGGCAGCTGGGACAGAGGCCTGGTGGCCCTGC
TGGGCAGCCCAACTGCTGGGGGAGACGTTTCTGCCACCCTGGGTGATGAGCAGCTTTTCCCCCCTGGCTTTCTGGGGGAGGAGTGGGCCT
CCTTAGGGAGACAGGTGACCCTGGGTGCCACCCCTGCCCCGTGTGTGCCCCGGGTGTTCTCAGTGGTTGCTGAAGGCAGGTAGAGGGTGC
TGTCCAGTATCCCCCATGTGAAGGTCACTTCCCTTCTCATGGAGTCAGCTGAGCATCAGCTCAGCCCTGCCATGTCCCCACTCACCCTCC
TCGCCTCCTGTCCGGCCCTGGGTTTCTAGCGGTGCCTGAGGCATCACTCTGGCCCATTGACAGATGAGAGGTCTGAAGCCTTCCTGGCCA
CAGGCATCACTTTCTCCTCCTCCTCATGCCCTGCCTTGTCCTTGTCGTGTTGCCATGGGGTTCTGAGAGGCTGGGAGTTCACAGACCTCA
GACACAGCTGAGTCCGACAACCATTGGGGTGGGGCTGCATCAGTCTCCGGAGTGGCCCGCCACCTCCTGAAGCAGGGCCTGGCCCACCCA
AGGTGCCTGGGGCAGGCGGGCACCGTCATTCGCTGCCATTGGCTTCTCAGATGTATTTCAAGGACTAAAGTGGGCTCTAAGATCTAAGAT
GGCCCGGCGCGGTGGCTCCCGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATGAGTTGAGGTCGGGAGTTTGAGTCCCCGT
CTCTACTAAAAATACAAAATTAGCCGGACAAGGTGGCGCATGCCTATAATCCCAGGTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAA
CCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGAGCAACAAAAGCAAAACTCTATCTTTAAAAAAAAAA
AAAAAAAAACTAAGATACCCATTCTTTCTGCCTTTGCCCAGGATGGAGGCTTTGAAGACAGGTGGTCACCTGGACCTGGGGTAAGGGTGC
GCAGGGAGGCCGGGCTTGGGGGCAGCCTGCTGCTATGTCCTTGCTGGCGCCCATACCTGTTGGACTGCCTGAACTTTGCTACTAGCCTGA
ACGACAGTGCCTTGGAAAGGCAGGCTCCATGCGGCAGCAACAGGATTGTCTTCGGTACCTTAAATATGCTCCCTGTGCTTCCCCAGGGAG
GATCTCTGGGAGCAGAGGGCGGCTGTAGACATCACAGCTGAAGAGGTGACCTCAGGCCCTGGGAGCCTCAGCTCCCTCTGCCCTGTACCC
TAGGCACGTGGCTCCAGCAAGAGCCCCAGGCAGGACAAAGGGAGCAGGCAGCAGCTGCAGAAACAGCCCTAGACAGGTGCTGGCCTCAAC
CCTGGCAGGGGAGGGGGAGCCCAGAGTGATGTTTCTCCTAAGGCCAAACCCCAGGGGTGGGTCATTTGAGAGGAGTTCCAGCTGTTCTGG
CCACACTGGGCTGGTGGGGAAGGAGCGGCGGCCTCTTTCCTTGGAGGGTCCCTGATTCCTGAGGATCCTCCCCGAGCCAGGCACGGGGGA
CCACAGGGCTGCCGTGAGCACCCACCCTGGTTCTCCAGGCCCCTCTGTCCAGAGGCAGGGCCTGAACCTCGGGCTCCTGCCTGGACCAGT
GACAGCATTGGGGAGAGAAGCACTGGGGGTCTTCAGACCAGCCAGCAAGGGGCCGTGCCAGTGCCCAGAGAGCAGGTCAGACAACAGGCA
ACCCTGAGGCAGCTGGCTCCCTCTCTCTGCCCTGCAGGGCTTGCCGCAGGGCGTGAGGCTCCCCAGCCACAGCCCCCTCTTACTTGCCTT
AAAACTGGAGAGAGGAATCTAGTATTTGCACTTAGCAAAATATTTAAAAACTGAAAAAAATGTGCATGATCTGTCACTTTGTATAAAAAC
AAGAAACGATTAGTTCATTAAACTTTTTCTTTACCTTCTGGTAGTAAAAATAGATAAAATAATTCCGTTTCAACTACTGTGTGTAAAAAG

>80884_80884_2_SETD2-RNF216_SETD2_chr3_47125209_ENST00000409792_RNF216_chr7_5756397_ENST00000425013_length(amino acids)=2409AA_BP=2032
LRGGGSRRRLQPLPMKQLQPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTKTKVNLEEQGRQKVSFS
FSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASP
PTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQ
DTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIE
KERDFKKSSAPLKSEDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHR
SSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEA
IKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPEREKAGSPA
PSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSE
LSPLVKACMLSSNGFQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVDTRVSCCKTKDSDIYCT
LNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRNLTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSL
PPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQEEGNSILPERRGR
PEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRL
QSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKNPEISFTQSSRKQIDNR
LPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQQEELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHV
DGLHSSEELRNLGWDFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPDSLTDDRE
EEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAVNEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKK
VRVEVEQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEIAC
GEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYF
MALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVS
IRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAEL
GDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTEADTDTPKKL
MFRRLKIISENSMDSAISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAEIEPKESN
GTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEEL
TQCADAHLFCKECLIRYAQEAVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSD
VKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSI
NGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEEEQKRKNGENTFKRIGPPLEKPVEKVQRVEALPRPVPQNLPQPQM

--------------------------------------------------------------
>80884_80884_3_SETD2-RNF216_SETD2_chr3_47125210_ENST00000409792_RNF216_chr7_5756397_ENST00000389902_length(transcript)=7484nt_BP=6103nt
GCTGCGGGGAGGGGGCTCGCGTCGCCGTCTCCAGCCGCTCCCGATGAAGCAGCTGCAGCCGCAGCCGCCTCCGAAGATGGGGGATTTCTA
CGACCCGGAGCACCCGACCCCTGAAGAAGAAGAAAATGAGGCAAAGATTGAAAATGTGCAGAAAACAGGTTTCATCAAAGGACCAATGTT
CAAAGGTGTTGCTTCTAGTCGATTTTTGCCCAAAGGCACCAAAACAAAAGTTAATTTGGAAGAACAGGGACGACAGAAGGTGTCATTCAG
CTTCAGCCTTACAAAGAAAACTTTGCAGAATAGGTTTCTCACTGCACTTGGCAATGAAAAGCAAAGTGATACTCCAAACCCTCCAGCTGT
ACCTCTTCAGGTAGACTCGACTCCTAAAATGAAAATGGAAATTGGTGATACCTTATCTACTGCAGAAGAATCTTCCCCACCAAAGTCAAG
GGTGGAATTGGGCAAAATTCATTTTAAGAAACATCTGCTTCATGTAACATCCAGGCCACTGCTGGCTACTACCACAGCAGTAGCATCTCC
ACCTACTCATGCAGCACCATTACCAGCAGTGATAGCAGAATCAACAACTGTAGACTCACCGCCCTCATCTCCGCCTCCACCGCCTCCACC
TGCCCAAGCCACAACACTCTCATCACCAGCACCAGTAACAGAGCCAGTGGCCTTGCCACATACACCAATAACAGTTCTAATGGCAGCACC
AGTACCCTTACCAGTAGATGTAGCAGTTAGATCTCTGAAAGAACCACCAATTATAATTGTACCAGAATCTTTAGAAGCAGATACTAAGCA
GGACACTATATCTAATAGTTTAGAAGAACACGTAACTCAAATATTGAATGAGCAAGCAGATATTTCCTCAAAAAAAGAAGATTCCCATAT
TGGGAAGGATGAAGAAATTCCAGATAGTTCTAAGATTAGTCTGAGCTGTAAAAAAACAGGTTCTAAGAAGAAATCCTCACAATCTGAAGG
CATCTTTCTTGGTTCAGAATCTGATGAAGATTCTGTACGGACTTCTTCAAGTCAAAGATCACATGATTTAAAATTTTCAGCAAGCATTGA
AAAGGAAAGAGATTTTAAAAAGAGCTCAGCACCTTTAAAAAGTGAGGATCTAGGGAAACCTTCACGATCTAAAACAGACAGAGATGATAA
ATATTTTAGCTATTCAAAACTTGAAAGAGATACTCGGTATGTATCTTCCCGATGTAGATCAGAAAGAGAGCGACGGCGGAGCAGATCTCA
CTCTAGGTCTGAGAGAGGCTCTAGAACTAATTTATCCTATTCCAGGTCAGAACGATCTCATTATTATGACTCTGATCGTCGCTACCATAG
GAGCTCCCCTTATCGAGAGAGGACGCGCTATTCTCGGCCATACACAGATAACAGAGCACGAGAGAGTTCTGACTCAGAAGAAGAGTATAA
GAAGACATACTCAAGGCGTACCTCATCTCATTCCTCTTCTTACAGAGACCTAAGGACATCATCCTATTCTAAATCTGATCGGGACTGTAA
AACTGAGACCTCTTACTTAGAGATGGAAAGAAGAGGCAAGTATTCTTCAAAACTAGAAAGAGAATCTAAAAGGACTTCAGAAAATGAAGC
AATTAAAAGATGTTGTTCTCCCCCTAATGAACTGGGATTCCGACGAGGGTCATCATATTCTAAGCATGACAGTAGTGCTTCCCGTTATAA
ATCTACCCTTTCAAAACCTATACCCAAGTCTGATAAATTTAAAAATTCTTTCTGTTGTACAGAATTAAATGAAGAAATCAAACAGTCTCA
TTCTTTTAGTTTACAGACACCTTGTTCAAAAGGTAGTGAATTAAGAATGATTAATAAAAATCCTGAAAGAGAAAAGGCTGGGTCTCCAGC
TCCATCAAATCGATTAAATGATTCACCTACTTTAAAAAAGCTAGATGAATTGCCTATTTTTAAGTCCGAATTTATAACACATGATAGCCA
TGATAGTATTAAGGAATTAGACTCTTTATCTAAAGTGAAGAATGATCAATTAAGAAGTTTTTGTCCCATAGAATTAAATATAAATGGATC
TCCTGGGGCAGAATCTGATTTGGCAACATTTTGCACTTCTAAAACTGATGCTGTTTTAATGACTTCTGATGATAGTGTGACTGGATCGGA
ATTATCCCCTTTGGTCAAAGCATGCATGCTTTCATCAAATGGATTTCAGAATATTAGTAGGTGCAAAGAAAAAGACTTGGATGATACCTG
CATGCTGCATAAGAAGTCAGAAAGCCCATTTAGAGAAACAGAACCTCTGGTGTCACCACACCAAGATAAACTCATGTCTATGCCAGTTAT
GACTGTGGATTATTCCAAAACAGTAGTTAAAGAACCAGTTGATACGAGGGTTTCTTGCTGCAAAACCAAAGATTCAGACATATACTGTAC
TTTGAACGATAGCAACCCTTCTTTGTGTAACTCTGAAGCTGAAAATATTGAGCCTTCAGTTATGAAGATTTCTTCAAATAGCTTTATGAA
TGTGCATTTGGAATCAAAACCAGTTATATGTGATAGTAGAAATTTGACAGATCACTCAAAATTTGCATGTGAAGAATATAAGCAGAGCAT
CGGTAGCACTAGTTCAGCTTCTGTTAATCATTTTGATGATTTATATCAACCTATTGGGAGTTCAGGTATTGCTTCATCTCTTCAGAGTCT
TCCACCAGGAATAAAGGTGGACAGTCTAACTCTCTTGAAATGCGGAGAGAACACATCTCCAGTTCTGGATGCAGTGCTAAAGAGTAAAAA
AAGTTCAGAGTTTTTAAAGCATGCAGGGAAAGAAACAATAGTAGAAGTAGGTAGTGACCTTCCTGATTCAGGAAAGGGATTTGCTTCCAG
GGAGAACAGGCGTAATAATGGGTTATCTGGGAAATGTTTGCAAGAGGCTCAAGAAGAAGGGAATTCCATATTGCCTGAAAGAAGAGGAAG
ACCAGAAATCTCTTTAGATGAAAGAGGAGAAGGAGGACATGTGCATACTTCTGATGACTCAGAAGTTGTATTTTCTTCTTGTGATTTGAA
TTTAACCATGGAAGACAGTGATGGTGTAACTTATGCATTAAAGTGTGACAGTAGTGGTCATGCCCCAGAAATTGTGTCTACAGTTCATGA
AGATTATTCTGGCTCTTCTGAAAGTTCAAATGATGAAAGTGATTCAGAAGATACAGATTCGGATGATAGCAGTATTCCAAGAAACCGTCT
CCAGTCTGTTGTGGTTGTGCCAAAGAATTCTACTTTGCCCATGGAAGAAACAAGTCCTTGTTCTTCTCGGAGCAGTCAAAGTTATAGACA
CTATTCTGACCATTGGGAAGATGAGAGATTGGAGTCAAGGAGACATTTGTATGAGGAAAAATTTGAAAGTATAGCAAGTAAAGCCTGTCC
TCAAACTGATAAGTTTTTCCTTCATAAAGGAACAGAGAAGAATCCGGAAATTTCTTTTACACAGTCCAGTAGAAAACAAATAGATAATCG
CCTGCCTGAACTTTCTCATCCTCAGAGTGATGGGGTTGATAGTACAAGTCATACAGATGTGAAATCTGACCCTCTGGGTCACCCAAATTC
AGAGGAAACCGTGAAAGCCAAAATACCTTCTAGGCAGCAAGAAGAGCTGCCAATTTATTCTTCTGATTTTGAAGATGTCCCAAATAAGTC
TTGGCAACAGACCACTTTCCAAAACAGGCCAGATAGTAGACTGGGAAAAACAGAATTGAGTTTTTCTTCCTCTTGTGAGATACCACATGT
GGATGGCTTGCACTCATCAGAAGAGCTCAGAAACTTAGGTTGGGACTTCTCTCAAGAAAAGCCTTCTACCACGTATCAGCAACCTGACAG
TAGCTATGGAGCTTGTGGTGGACACAAGTATCAGCAAAATGCAGAACAGTATGGTGGGACACGTGATTACTGGCAAGGCAATGGTTACTG
GGATCCAAGATCAGGTAGACCTCCTGGAACTGGGGTTGTGTATGATCGAACTCAAGGACAAGTACCAGATTCCCTAACAGATGATCGTGA
AGAAGAGGAGAATTGGGATCAACAGGATGGATCCCATTTTTCAGACCAGTCCGATAAATTTCTTCTATCCCTTCAGAAAGACAAGGGGTC
AGTGCAAGCACCTGAAATAAGCAGCAATTCCATTAAGGACACTTTAGCTGTGAATGAAAAGAAAGATTTTTCAAAAAACTTAGAAAAAAA
TGATATCAAAGATAGAGGGCCTCTTAAAAAAAGGAGGCAGGAAATAGAGAGTGATTCTGAAAGTGATGGTGAGCTTCAGGACAGAAAGAA
AGTTAGAGTGGAGGTAGAGCAGGGAGAGACATCAGTGCCCCCAGGTTCAGCACTGGTTGGGCCCTCCTGTGTCATGGATGACTTCAGGGA
CCCACAGCGATGGAAGGAATGTGCCAAGCAAGGGAAAATGCCATGTTACTTTGATCTTATTGAAGAAAATGTTTATTTAACAGAAAGAAA
GAAGAATAAATCTCATCGAGATATTAAGCGAATGCAGTGTGAGTGTACACCTCTTTCTAAAGATGAAAGAGCTCAAGGTGAAATAGCATG
TGGGGAAGATTGTCTTAATCGTCTTCTCATGATTGAATGTTCTTCTCGGTGTCCAAATGGGGATTATTGTTCCAATAGACGGTTTCAGAG
AAAACAGCATGCAGATGTGGAAGTCATACTCACAGAAAAGAAAGGCTGGGGCTTGAGAGCTGCCAAAGACCTTCCTTCGAACACCTTTGT
CCTAGAATATTGTGGAGAGGTACTCGATCATAAAGAGTTTAAAGCTCGAGTGAAGGAGTATGCACGAAACAAAAACATCCATTACTATTT
CATGGCCCTGAAGAATGATGAGATAATAGATGCCACTCAAAAAGGAAATTGCTCTCGTTTCATGAATCACAGCTGTGAACCAAATTGTGA
AACCCAAAAATGGACTGTGAACGGACAACTGAGGGTTGGGTTTTTTACCACCAAACTGGTTCCTTCAGGCTCAGAGTTAACGTTTGACTA
TCAGTTCCAGAGATATGGAAAAGAAGCCCAGAAATGTTTCTGCGGATCAGCCAATTGCCGGGGTTACCTGGGAGGAGAAAACAGAGTCAG
CATCAGAGCAGCAGGAGGGAAAATGAAGAAGGAACGATCTCGTAAGAAGGATTCAGTGGATGGAGAGCTAGAAGCTCTGATGGAAAATGG
TGAGGGTCTCTCTGATAAAAACCAGGTGCTCAGCTTATCCCGGCTAATGGTTAGAATTGAAACTTTGGAGCAGAAACTTACCTGTCTGGA
ACTCATACAGAACACACACTCACAGTCCTGCCTGAAGTCCTTTCTGGAACGTCATGGGCTGTCTTTGTTGTGGATCTGGATGGCAGAGCT
AGGTGACGGCCGGGAAAGTAACCAGAAGCTTCAGGAAGAGATTATAAAGACTTTGGAACACTTGCCCATTCCTACTAAAAATATGTTGGA
GGAAAGCAAAGTACTTCCAATTATTCAACGCTGGTCTCAGACTAAGACTGCTGTCCCTCCGTTGAGTGAAGGAGATGGGTATTCTAGTGA
GAATACATCGCGTGCTCATACACCACTCAACACACCTGATCCTTCCACCAAGCTGAGCACAGAAGCTGACACAGACACTCCCAAGAAACT
AATGTTTCGCAGACTGAAAATTATAAGTGAAAATAGCATGGACAGTGCAATCTCTGATGCAACCAGTGAGCTAGAAGGCAAGGATGGCAA
AGAGGATCTTGATCAATTAGAAAATGTCCCTGTAGAGGAAGAGGAAGAATTGCAGTCACAACAGCTACTCCCACAACAGCTGCCTGAATG
CAAAGTTGATAGTGAAACCAACATAGAAGCTAGTAAGCTACCTACATCTGAACCAGAAGCTGACGCTGAAATAGAGCCCAAAGAGAGCAA
CGGCACAAAACTAGAAGAACCTATTAATGAAGAAACACCATCCCAAGATGAAGAGGAGGGTGTGTCTGATGTGGAGAGTGAAAGGAGCCA
AGAACAGCCAGATAAAACAGTGGATATAAGTGATTTGGCCACCAAACTCCTGGACAGTTGGAAAGACCTAAAGCATGAAGACTTTTTGCT
TGCCCTACAGATGAATGAAGAACAGTATCAAAAGGATGGCCAGCTGATTGAGTGTCGCTGCTGCTATGGGGAATTTCCATTCGAGGAGCT
GACGCAGTGCGCAGATGCTCACTTGTTCTGCAAAGAGTGTCTCATCAGATATGCCCAAGAGGCAGTCTTTGGATCTGGAAAGTTGGAGCT
CAGCTGCATGGAAGGCAGCTGCACGTGTTCGTTCCCAACCAGTGAGCTGGAGAAGGTGCTCCCCCAGACCATCCTGTATAAGTACTATGA
GCGAAAAGCCGAGGAGGAGGTTGCGGCAGCCTACGCCGACGAGCTTGTCAGGTGCCCGTCCTGTAGCTTTCCGGCTCTGTTGGACAGTGA
TGTGAAGAGGTTCAGCTGTCCTAATCCTCACTGCCGAAAGGAAACCTGTAGGAAGTGTCAGGGACTCTGGAAAGAACATAATGGCCTCAC
CTGTGAAGAGCTGGCTGAAAAAGACGACATCAAGTACCGTACCTCTATTGAAGAAAAAATGACTGCTGCCCGCATTAGAAAATGCCACAA
GTGTGGGACTGGCCTCATCAAATCTGAAGGCTGCAACCGCATGTCTTGCCGCTGTGGTGCCCAGATGTGCTACCTCTGTCGAGTTTCTAT
TAATGGATATGACCATTTCTGCCAACATCCCCGCTCACCAGGAGCCCCTTGCCAGGAGTGTTCAAGATGCTCTCTCTGGACCGATCCCAC
TGAAGATGATGAGAAGCTTATTGAGGAAATCCAGAAGGAGGCTGAAGAGGAACAGAAAAGAAAGAATGGAGAGAACACCTTCAAACGCAT
TGGACCCCCGCTGGAGAAGCCTGTGGAGAAGGTGCAGAGGGTGGAGGCCCTCCCGAGGCCCGTTCCGCAGAACCTGCCACAGCCACAGAT
GCCACCCTATGCCTTCGCGCACCCACCCTTCCCCCTGCCTCCCGTGCGGCCTGTGTTCAACAACTTCCCACTCAACATGGGGCCTATCCC
AGCCCCGTACGTGCCCCCTCTGCCCAACGTGCGGGTCAACTATGACTTCGGTCCCATCCACATGCCCCTGGAGCACAACCTGCCCATGCA
CTTTGGCCCCCAGCCGCGGCATCGCTTCTGATGGCCCCGAATCCCCATTGAGCAGCACAAAGCCCGTTTGGGGTAGGAGTGTGGATGGAG
AACCCTCCCCCAAGGCTGGTGTCTGTACCATTGCATCCTAAGTCAGCTTGAAGGGTAGGCTGGTTTTCTTCCCACCCCTTTCCTAGAAGG
GCTACTGCTCCTGGAAGAGTGGACGGATCCATAATAAAGACGTCCCAAATGGTGGAGTTCGGAGAGAGCTGCGATGTGAACTGCCCCTCC

>80884_80884_3_SETD2-RNF216_SETD2_chr3_47125210_ENST00000409792_RNF216_chr7_5756397_ENST00000389902_length(amino acids)=2409AA_BP=2032
LRGGGSRRRLQPLPMKQLQPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTKTKVNLEEQGRQKVSFS
FSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASP
PTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQ
DTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIE
KERDFKKSSAPLKSEDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHR
SSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEA
IKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPEREKAGSPA
PSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSE
LSPLVKACMLSSNGFQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVDTRVSCCKTKDSDIYCT
LNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRNLTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSL
PPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQEEGNSILPERRGR
PEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRL
QSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKNPEISFTQSSRKQIDNR
LPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQQEELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHV
DGLHSSEELRNLGWDFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPDSLTDDRE
EEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAVNEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKK
VRVEVEQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEIAC
GEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYF
MALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVS
IRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAEL
GDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTEADTDTPKKL
MFRRLKIISENSMDSAISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAEIEPKESN
GTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEEL
TQCADAHLFCKECLIRYAQEAVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSD
VKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSI
NGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEEEQKRKNGENTFKRIGPPLEKPVEKVQRVEALPRPVPQNLPQPQM

--------------------------------------------------------------
>80884_80884_4_SETD2-RNF216_SETD2_chr3_47125210_ENST00000409792_RNF216_chr7_5756397_ENST00000425013_length(transcript)=10044nt_BP=6103nt
GCTGCGGGGAGGGGGCTCGCGTCGCCGTCTCCAGCCGCTCCCGATGAAGCAGCTGCAGCCGCAGCCGCCTCCGAAGATGGGGGATTTCTA
CGACCCGGAGCACCCGACCCCTGAAGAAGAAGAAAATGAGGCAAAGATTGAAAATGTGCAGAAAACAGGTTTCATCAAAGGACCAATGTT
CAAAGGTGTTGCTTCTAGTCGATTTTTGCCCAAAGGCACCAAAACAAAAGTTAATTTGGAAGAACAGGGACGACAGAAGGTGTCATTCAG
CTTCAGCCTTACAAAGAAAACTTTGCAGAATAGGTTTCTCACTGCACTTGGCAATGAAAAGCAAAGTGATACTCCAAACCCTCCAGCTGT
ACCTCTTCAGGTAGACTCGACTCCTAAAATGAAAATGGAAATTGGTGATACCTTATCTACTGCAGAAGAATCTTCCCCACCAAAGTCAAG
GGTGGAATTGGGCAAAATTCATTTTAAGAAACATCTGCTTCATGTAACATCCAGGCCACTGCTGGCTACTACCACAGCAGTAGCATCTCC
ACCTACTCATGCAGCACCATTACCAGCAGTGATAGCAGAATCAACAACTGTAGACTCACCGCCCTCATCTCCGCCTCCACCGCCTCCACC
TGCCCAAGCCACAACACTCTCATCACCAGCACCAGTAACAGAGCCAGTGGCCTTGCCACATACACCAATAACAGTTCTAATGGCAGCACC
AGTACCCTTACCAGTAGATGTAGCAGTTAGATCTCTGAAAGAACCACCAATTATAATTGTACCAGAATCTTTAGAAGCAGATACTAAGCA
GGACACTATATCTAATAGTTTAGAAGAACACGTAACTCAAATATTGAATGAGCAAGCAGATATTTCCTCAAAAAAAGAAGATTCCCATAT
TGGGAAGGATGAAGAAATTCCAGATAGTTCTAAGATTAGTCTGAGCTGTAAAAAAACAGGTTCTAAGAAGAAATCCTCACAATCTGAAGG
CATCTTTCTTGGTTCAGAATCTGATGAAGATTCTGTACGGACTTCTTCAAGTCAAAGATCACATGATTTAAAATTTTCAGCAAGCATTGA
AAAGGAAAGAGATTTTAAAAAGAGCTCAGCACCTTTAAAAAGTGAGGATCTAGGGAAACCTTCACGATCTAAAACAGACAGAGATGATAA
ATATTTTAGCTATTCAAAACTTGAAAGAGATACTCGGTATGTATCTTCCCGATGTAGATCAGAAAGAGAGCGACGGCGGAGCAGATCTCA
CTCTAGGTCTGAGAGAGGCTCTAGAACTAATTTATCCTATTCCAGGTCAGAACGATCTCATTATTATGACTCTGATCGTCGCTACCATAG
GAGCTCCCCTTATCGAGAGAGGACGCGCTATTCTCGGCCATACACAGATAACAGAGCACGAGAGAGTTCTGACTCAGAAGAAGAGTATAA
GAAGACATACTCAAGGCGTACCTCATCTCATTCCTCTTCTTACAGAGACCTAAGGACATCATCCTATTCTAAATCTGATCGGGACTGTAA
AACTGAGACCTCTTACTTAGAGATGGAAAGAAGAGGCAAGTATTCTTCAAAACTAGAAAGAGAATCTAAAAGGACTTCAGAAAATGAAGC
AATTAAAAGATGTTGTTCTCCCCCTAATGAACTGGGATTCCGACGAGGGTCATCATATTCTAAGCATGACAGTAGTGCTTCCCGTTATAA
ATCTACCCTTTCAAAACCTATACCCAAGTCTGATAAATTTAAAAATTCTTTCTGTTGTACAGAATTAAATGAAGAAATCAAACAGTCTCA
TTCTTTTAGTTTACAGACACCTTGTTCAAAAGGTAGTGAATTAAGAATGATTAATAAAAATCCTGAAAGAGAAAAGGCTGGGTCTCCAGC
TCCATCAAATCGATTAAATGATTCACCTACTTTAAAAAAGCTAGATGAATTGCCTATTTTTAAGTCCGAATTTATAACACATGATAGCCA
TGATAGTATTAAGGAATTAGACTCTTTATCTAAAGTGAAGAATGATCAATTAAGAAGTTTTTGTCCCATAGAATTAAATATAAATGGATC
TCCTGGGGCAGAATCTGATTTGGCAACATTTTGCACTTCTAAAACTGATGCTGTTTTAATGACTTCTGATGATAGTGTGACTGGATCGGA
ATTATCCCCTTTGGTCAAAGCATGCATGCTTTCATCAAATGGATTTCAGAATATTAGTAGGTGCAAAGAAAAAGACTTGGATGATACCTG
CATGCTGCATAAGAAGTCAGAAAGCCCATTTAGAGAAACAGAACCTCTGGTGTCACCACACCAAGATAAACTCATGTCTATGCCAGTTAT
GACTGTGGATTATTCCAAAACAGTAGTTAAAGAACCAGTTGATACGAGGGTTTCTTGCTGCAAAACCAAAGATTCAGACATATACTGTAC
TTTGAACGATAGCAACCCTTCTTTGTGTAACTCTGAAGCTGAAAATATTGAGCCTTCAGTTATGAAGATTTCTTCAAATAGCTTTATGAA
TGTGCATTTGGAATCAAAACCAGTTATATGTGATAGTAGAAATTTGACAGATCACTCAAAATTTGCATGTGAAGAATATAAGCAGAGCAT
CGGTAGCACTAGTTCAGCTTCTGTTAATCATTTTGATGATTTATATCAACCTATTGGGAGTTCAGGTATTGCTTCATCTCTTCAGAGTCT
TCCACCAGGAATAAAGGTGGACAGTCTAACTCTCTTGAAATGCGGAGAGAACACATCTCCAGTTCTGGATGCAGTGCTAAAGAGTAAAAA
AAGTTCAGAGTTTTTAAAGCATGCAGGGAAAGAAACAATAGTAGAAGTAGGTAGTGACCTTCCTGATTCAGGAAAGGGATTTGCTTCCAG
GGAGAACAGGCGTAATAATGGGTTATCTGGGAAATGTTTGCAAGAGGCTCAAGAAGAAGGGAATTCCATATTGCCTGAAAGAAGAGGAAG
ACCAGAAATCTCTTTAGATGAAAGAGGAGAAGGAGGACATGTGCATACTTCTGATGACTCAGAAGTTGTATTTTCTTCTTGTGATTTGAA
TTTAACCATGGAAGACAGTGATGGTGTAACTTATGCATTAAAGTGTGACAGTAGTGGTCATGCCCCAGAAATTGTGTCTACAGTTCATGA
AGATTATTCTGGCTCTTCTGAAAGTTCAAATGATGAAAGTGATTCAGAAGATACAGATTCGGATGATAGCAGTATTCCAAGAAACCGTCT
CCAGTCTGTTGTGGTTGTGCCAAAGAATTCTACTTTGCCCATGGAAGAAACAAGTCCTTGTTCTTCTCGGAGCAGTCAAAGTTATAGACA
CTATTCTGACCATTGGGAAGATGAGAGATTGGAGTCAAGGAGACATTTGTATGAGGAAAAATTTGAAAGTATAGCAAGTAAAGCCTGTCC
TCAAACTGATAAGTTTTTCCTTCATAAAGGAACAGAGAAGAATCCGGAAATTTCTTTTACACAGTCCAGTAGAAAACAAATAGATAATCG
CCTGCCTGAACTTTCTCATCCTCAGAGTGATGGGGTTGATAGTACAAGTCATACAGATGTGAAATCTGACCCTCTGGGTCACCCAAATTC
AGAGGAAACCGTGAAAGCCAAAATACCTTCTAGGCAGCAAGAAGAGCTGCCAATTTATTCTTCTGATTTTGAAGATGTCCCAAATAAGTC
TTGGCAACAGACCACTTTCCAAAACAGGCCAGATAGTAGACTGGGAAAAACAGAATTGAGTTTTTCTTCCTCTTGTGAGATACCACATGT
GGATGGCTTGCACTCATCAGAAGAGCTCAGAAACTTAGGTTGGGACTTCTCTCAAGAAAAGCCTTCTACCACGTATCAGCAACCTGACAG
TAGCTATGGAGCTTGTGGTGGACACAAGTATCAGCAAAATGCAGAACAGTATGGTGGGACACGTGATTACTGGCAAGGCAATGGTTACTG
GGATCCAAGATCAGGTAGACCTCCTGGAACTGGGGTTGTGTATGATCGAACTCAAGGACAAGTACCAGATTCCCTAACAGATGATCGTGA
AGAAGAGGAGAATTGGGATCAACAGGATGGATCCCATTTTTCAGACCAGTCCGATAAATTTCTTCTATCCCTTCAGAAAGACAAGGGGTC
AGTGCAAGCACCTGAAATAAGCAGCAATTCCATTAAGGACACTTTAGCTGTGAATGAAAAGAAAGATTTTTCAAAAAACTTAGAAAAAAA
TGATATCAAAGATAGAGGGCCTCTTAAAAAAAGGAGGCAGGAAATAGAGAGTGATTCTGAAAGTGATGGTGAGCTTCAGGACAGAAAGAA
AGTTAGAGTGGAGGTAGAGCAGGGAGAGACATCAGTGCCCCCAGGTTCAGCACTGGTTGGGCCCTCCTGTGTCATGGATGACTTCAGGGA
CCCACAGCGATGGAAGGAATGTGCCAAGCAAGGGAAAATGCCATGTTACTTTGATCTTATTGAAGAAAATGTTTATTTAACAGAAAGAAA
GAAGAATAAATCTCATCGAGATATTAAGCGAATGCAGTGTGAGTGTACACCTCTTTCTAAAGATGAAAGAGCTCAAGGTGAAATAGCATG
TGGGGAAGATTGTCTTAATCGTCTTCTCATGATTGAATGTTCTTCTCGGTGTCCAAATGGGGATTATTGTTCCAATAGACGGTTTCAGAG
AAAACAGCATGCAGATGTGGAAGTCATACTCACAGAAAAGAAAGGCTGGGGCTTGAGAGCTGCCAAAGACCTTCCTTCGAACACCTTTGT
CCTAGAATATTGTGGAGAGGTACTCGATCATAAAGAGTTTAAAGCTCGAGTGAAGGAGTATGCACGAAACAAAAACATCCATTACTATTT
CATGGCCCTGAAGAATGATGAGATAATAGATGCCACTCAAAAAGGAAATTGCTCTCGTTTCATGAATCACAGCTGTGAACCAAATTGTGA
AACCCAAAAATGGACTGTGAACGGACAACTGAGGGTTGGGTTTTTTACCACCAAACTGGTTCCTTCAGGCTCAGAGTTAACGTTTGACTA
TCAGTTCCAGAGATATGGAAAAGAAGCCCAGAAATGTTTCTGCGGATCAGCCAATTGCCGGGGTTACCTGGGAGGAGAAAACAGAGTCAG
CATCAGAGCAGCAGGAGGGAAAATGAAGAAGGAACGATCTCGTAAGAAGGATTCAGTGGATGGAGAGCTAGAAGCTCTGATGGAAAATGG
TGAGGGTCTCTCTGATAAAAACCAGGTGCTCAGCTTATCCCGGCTAATGGTTAGAATTGAAACTTTGGAGCAGAAACTTACCTGTCTGGA
ACTCATACAGAACACACACTCACAGTCCTGCCTGAAGTCCTTTCTGGAACGTCATGGGCTGTCTTTGTTGTGGATCTGGATGGCAGAGCT
AGGTGACGGCCGGGAAAGTAACCAGAAGCTTCAGGAAGAGATTATAAAGACTTTGGAACACTTGCCCATTCCTACTAAAAATATGTTGGA
GGAAAGCAAAGTACTTCCAATTATTCAACGCTGGTCTCAGACTAAGACTGCTGTCCCTCCGTTGAGTGAAGGAGATGGGTATTCTAGTGA
GAATACATCGCGTGCTCATACACCACTCAACACACCTGATCCTTCCACCAAGCTGAGCACAGAAGCTGACACAGACACTCCCAAGAAACT
AATGTTTCGCAGACTGAAAATTATAAGTGAAAATAGCATGGACAGTGCAATCTCTGATGCAACCAGTGAGCTAGAAGGCAAGGATGGCAA
AGAGGATCTTGATCAATTAGAAAATGTCCCTGTAGAGGAAGAGGAAGAATTGCAGTCACAACAGCTACTCCCACAACAGCTGCCTGAATG
CAAAGTTGATAGTGAAACCAACATAGAAGCTAGTAAGCTACCTACATCTGAACCAGAAGCTGACGCTGAAATAGAGCCCAAAGAGAGCAA
CGGCACAAAACTAGAAGAACCTATTAATGAAGAAACACCATCCCAAGATGAAGAGGAGGGTGTGTCTGATGTGGAGAGTGAAAGGAGCCA
AGAACAGCCAGATAAAACAGTGGATATAAGTGATTTGGCCACCAAACTCCTGGACAGTTGGAAAGACCTAAAGCATGAAGACTTTTTGCT
TGCCCTACAGATGAATGAAGAACAGTATCAAAAGGATGGCCAGCTGATTGAGTGTCGCTGCTGCTATGGGGAATTTCCATTCGAGGAGCT
GACGCAGTGCGCAGATGCTCACTTGTTCTGCAAAGAGTGTCTCATCAGATATGCCCAAGAGGCAGTCTTTGGATCTGGAAAGTTGGAGCT
CAGCTGCATGGAAGGCAGCTGCACGTGTTCGTTCCCAACCAGTGAGCTGGAGAAGGTGCTCCCCCAGACCATCCTGTATAAGTACTATGA
GCGAAAAGCCGAGGAGGAGGTTGCGGCAGCCTACGCCGACGAGCTTGTCAGGTGCCCGTCCTGTAGCTTTCCGGCTCTGTTGGACAGTGA
TGTGAAGAGGTTCAGCTGTCCTAATCCTCACTGCCGAAAGGAAACCTGTAGGAAGTGTCAGGGACTCTGGAAAGAACATAATGGCCTCAC
CTGTGAAGAGCTGGCTGAAAAAGACGACATCAAGTACCGTACCTCTATTGAAGAAAAAATGACTGCTGCCCGCATTAGAAAATGCCACAA
GTGTGGGACTGGCCTCATCAAATCTGAAGGCTGCAACCGCATGTCTTGCCGCTGTGGTGCCCAGATGTGCTACCTCTGTCGAGTTTCTAT
TAATGGATATGACCATTTCTGCCAACATCCCCGCTCACCAGGAGCCCCTTGCCAGGAGTGTTCAAGATGCTCTCTCTGGACCGATCCCAC
TGAAGATGATGAGAAGCTTATTGAGGAAATCCAGAAGGAGGCTGAAGAGGAACAGAAAAGAAAGAATGGAGAGAACACCTTCAAACGCAT
TGGACCCCCGCTGGAGAAGCCTGTGGAGAAGGTGCAGAGGGTGGAGGCCCTCCCGAGGCCCGTTCCGCAGAACCTGCCACAGCCACAGAT
GCCACCCTATGCCTTCGCGCACCCACCCTTCCCCCTGCCTCCCGTGCGGCCTGTGTTCAACAACTTCCCACTCAACATGGGGCCTATCCC
AGCCCCGTACGTGCCCCCTCTGCCCAACGTGCGGGTCAACTATGACTTCGGTCCCATCCACATGCCCCTGGAGCACAACCTGCCCATGCA
CTTTGGCCCCCAGCCGCGGCATCGCTTCTGATGGCCCCGAATCCCCATTGAGCAGCACAAAGCCCGTTTGGGGTAGGAGTGTGGATGGAG
AACCCTCCCCCAAGGCTGGTGTCTGTACCATTGCATCCTAAGTCAGCTTGAAGGGTAGGCTGGTTTTCTTCCCACCCCTTTCCTAGAAGG
GCTACTGCTCCTGGAAGAGTGGACGGATCCATAATAAAGACGTCCCAAATGGTGGAGTTCGGAGAGAGCTGCGATGTGAACTGCCCCTCC
CCTCGCATCCCCCAGGCCACCAACGGCAGTCCTTCTGCCTTGTCCATGGCATAGGCCATAGACCAGGTCCCTGCTGCTCACACCTGGGCC
TCTCCTCGGAGCCGACCCCTGGGTAGCAAGGCAGCCGAGAGCATCTCCCTGGAGGGGCCCACGGTTGGGCCAAGGGCAGAGGGGGCTGCA
CCTGCGGGCCTGGGAAGCATTGCTCAGGGTGGGGGGCTGGGACCATGGCCCGCAGAGGCACTGCCACAGCTGTGAGGGCCAAGATGCTGT
CCCCCCATCCAAAACCCGTGCGCCACTGCAGTGAGTGTTGAGGGCACCTCTCCTCCCCTCTTACACCTACTCAGATGAGGCAGCAGCAGA
CCCATCTCGCGGCGGGGGTTTTGTTCTGTTGCCGCCTAACTTTCTCATCCTCGGTCTCTGGAAAGTCAGGCTGAGAAATCCTTTCCCAGG
CCAGGCCGCTGCGGTACACTGGATGGTTCTGAAGCTGGCCCATTGAAAGAGCCTCTTAAGGCAGCTGGGACAGAGGCCTGGTGGCCCTGC
TGGGCAGCCCAACTGCTGGGGGAGACGTTTCTGCCACCCTGGGTGATGAGCAGCTTTTCCCCCCTGGCTTTCTGGGGGAGGAGTGGGCCT
CCTTAGGGAGACAGGTGACCCTGGGTGCCACCCCTGCCCCGTGTGTGCCCCGGGTGTTCTCAGTGGTTGCTGAAGGCAGGTAGAGGGTGC
TGTCCAGTATCCCCCATGTGAAGGTCACTTCCCTTCTCATGGAGTCAGCTGAGCATCAGCTCAGCCCTGCCATGTCCCCACTCACCCTCC
TCGCCTCCTGTCCGGCCCTGGGTTTCTAGCGGTGCCTGAGGCATCACTCTGGCCCATTGACAGATGAGAGGTCTGAAGCCTTCCTGGCCA
CAGGCATCACTTTCTCCTCCTCCTCATGCCCTGCCTTGTCCTTGTCGTGTTGCCATGGGGTTCTGAGAGGCTGGGAGTTCACAGACCTCA
GACACAGCTGAGTCCGACAACCATTGGGGTGGGGCTGCATCAGTCTCCGGAGTGGCCCGCCACCTCCTGAAGCAGGGCCTGGCCCACCCA
AGGTGCCTGGGGCAGGCGGGCACCGTCATTCGCTGCCATTGGCTTCTCAGATGTATTTCAAGGACTAAAGTGGGCTCTAAGATCTAAGAT
GGCCCGGCGCGGTGGCTCCCGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCGGATGAGTTGAGGTCGGGAGTTTGAGTCCCCGT
CTCTACTAAAAATACAAAATTAGCCGGACAAGGTGGCGCATGCCTATAATCCCAGGTACTCAGGAGGCTGAGGCAGGAGAATCACTTGAA
CCTGGGAGGCAGAGGTTGCAGTGAGCCAAGATTGTGCCACTGCACTCCAGCCTGAGCAACAAAAGCAAAACTCTATCTTTAAAAAAAAAA
AAAAAAAAACTAAGATACCCATTCTTTCTGCCTTTGCCCAGGATGGAGGCTTTGAAGACAGGTGGTCACCTGGACCTGGGGTAAGGGTGC
GCAGGGAGGCCGGGCTTGGGGGCAGCCTGCTGCTATGTCCTTGCTGGCGCCCATACCTGTTGGACTGCCTGAACTTTGCTACTAGCCTGA
ACGACAGTGCCTTGGAAAGGCAGGCTCCATGCGGCAGCAACAGGATTGTCTTCGGTACCTTAAATATGCTCCCTGTGCTTCCCCAGGGAG
GATCTCTGGGAGCAGAGGGCGGCTGTAGACATCACAGCTGAAGAGGTGACCTCAGGCCCTGGGAGCCTCAGCTCCCTCTGCCCTGTACCC
TAGGCACGTGGCTCCAGCAAGAGCCCCAGGCAGGACAAAGGGAGCAGGCAGCAGCTGCAGAAACAGCCCTAGACAGGTGCTGGCCTCAAC
CCTGGCAGGGGAGGGGGAGCCCAGAGTGATGTTTCTCCTAAGGCCAAACCCCAGGGGTGGGTCATTTGAGAGGAGTTCCAGCTGTTCTGG
CCACACTGGGCTGGTGGGGAAGGAGCGGCGGCCTCTTTCCTTGGAGGGTCCCTGATTCCTGAGGATCCTCCCCGAGCCAGGCACGGGGGA
CCACAGGGCTGCCGTGAGCACCCACCCTGGTTCTCCAGGCCCCTCTGTCCAGAGGCAGGGCCTGAACCTCGGGCTCCTGCCTGGACCAGT
GACAGCATTGGGGAGAGAAGCACTGGGGGTCTTCAGACCAGCCAGCAAGGGGCCGTGCCAGTGCCCAGAGAGCAGGTCAGACAACAGGCA
ACCCTGAGGCAGCTGGCTCCCTCTCTCTGCCCTGCAGGGCTTGCCGCAGGGCGTGAGGCTCCCCAGCCACAGCCCCCTCTTACTTGCCTT
AAAACTGGAGAGAGGAATCTAGTATTTGCACTTAGCAAAATATTTAAAAACTGAAAAAAATGTGCATGATCTGTCACTTTGTATAAAAAC
AAGAAACGATTAGTTCATTAAACTTTTTCTTTACCTTCTGGTAGTAAAAATAGATAAAATAATTCCGTTTCAACTACTGTGTGTAAAAAG

>80884_80884_4_SETD2-RNF216_SETD2_chr3_47125210_ENST00000409792_RNF216_chr7_5756397_ENST00000425013_length(amino acids)=2409AA_BP=2032
LRGGGSRRRLQPLPMKQLQPQPPPKMGDFYDPEHPTPEEEENEAKIENVQKTGFIKGPMFKGVASSRFLPKGTKTKVNLEEQGRQKVSFS
FSLTKKTLQNRFLTALGNEKQSDTPNPPAVPLQVDSTPKMKMEIGDTLSTAEESSPPKSRVELGKIHFKKHLLHVTSRPLLATTTAVASP
PTHAAPLPAVIAESTTVDSPPSSPPPPPPPAQATTLSSPAPVTEPVALPHTPITVLMAAPVPLPVDVAVRSLKEPPIIIVPESLEADTKQ
DTISNSLEEHVTQILNEQADISSKKEDSHIGKDEEIPDSSKISLSCKKTGSKKKSSQSEGIFLGSESDEDSVRTSSSQRSHDLKFSASIE
KERDFKKSSAPLKSEDLGKPSRSKTDRDDKYFSYSKLERDTRYVSSRCRSERERRRSRSHSRSERGSRTNLSYSRSERSHYYDSDRRYHR
SSPYRERTRYSRPYTDNRARESSDSEEEYKKTYSRRTSSHSSSYRDLRTSSYSKSDRDCKTETSYLEMERRGKYSSKLERESKRTSENEA
IKRCCSPPNELGFRRGSSYSKHDSSASRYKSTLSKPIPKSDKFKNSFCCTELNEEIKQSHSFSLQTPCSKGSELRMINKNPEREKAGSPA
PSNRLNDSPTLKKLDELPIFKSEFITHDSHDSIKELDSLSKVKNDQLRSFCPIELNINGSPGAESDLATFCTSKTDAVLMTSDDSVTGSE
LSPLVKACMLSSNGFQNISRCKEKDLDDTCMLHKKSESPFRETEPLVSPHQDKLMSMPVMTVDYSKTVVKEPVDTRVSCCKTKDSDIYCT
LNDSNPSLCNSEAENIEPSVMKISSNSFMNVHLESKPVICDSRNLTDHSKFACEEYKQSIGSTSSASVNHFDDLYQPIGSSGIASSLQSL
PPGIKVDSLTLLKCGENTSPVLDAVLKSKKSSEFLKHAGKETIVEVGSDLPDSGKGFASRENRRNNGLSGKCLQEAQEEGNSILPERRGR
PEISLDERGEGGHVHTSDDSEVVFSSCDLNLTMEDSDGVTYALKCDSSGHAPEIVSTVHEDYSGSSESSNDESDSEDTDSDDSSIPRNRL
QSVVVVPKNSTLPMEETSPCSSRSSQSYRHYSDHWEDERLESRRHLYEEKFESIASKACPQTDKFFLHKGTEKNPEISFTQSSRKQIDNR
LPELSHPQSDGVDSTSHTDVKSDPLGHPNSEETVKAKIPSRQQEELPIYSSDFEDVPNKSWQQTTFQNRPDSRLGKTELSFSSSCEIPHV
DGLHSSEELRNLGWDFSQEKPSTTYQQPDSSYGACGGHKYQQNAEQYGGTRDYWQGNGYWDPRSGRPPGTGVVYDRTQGQVPDSLTDDRE
EEENWDQQDGSHFSDQSDKFLLSLQKDKGSVQAPEISSNSIKDTLAVNEKKDFSKNLEKNDIKDRGPLKKRRQEIESDSESDGELQDRKK
VRVEVEQGETSVPPGSALVGPSCVMDDFRDPQRWKECAKQGKMPCYFDLIEENVYLTERKKNKSHRDIKRMQCECTPLSKDERAQGEIAC
GEDCLNRLLMIECSSRCPNGDYCSNRRFQRKQHADVEVILTEKKGWGLRAAKDLPSNTFVLEYCGEVLDHKEFKARVKEYARNKNIHYYF
MALKNDEIIDATQKGNCSRFMNHSCEPNCETQKWTVNGQLRVGFFTTKLVPSGSELTFDYQFQRYGKEAQKCFCGSANCRGYLGGENRVS
IRAAGGKMKKERSRKKDSVDGELEALMENGEGLSDKNQVLSLSRLMVRIETLEQKLTCLELIQNTHSQSCLKSFLERHGLSLLWIWMAEL
GDGRESNQKLQEEIIKTLEHLPIPTKNMLEESKVLPIIQRWSQTKTAVPPLSEGDGYSSENTSRAHTPLNTPDPSTKLSTEADTDTPKKL
MFRRLKIISENSMDSAISDATSELEGKDGKEDLDQLENVPVEEEEELQSQQLLPQQLPECKVDSETNIEASKLPTSEPEADAEIEPKESN
GTKLEEPINEETPSQDEEEGVSDVESERSQEQPDKTVDISDLATKLLDSWKDLKHEDFLLALQMNEEQYQKDGQLIECRCCYGEFPFEEL
TQCADAHLFCKECLIRYAQEAVFGSGKLELSCMEGSCTCSFPTSELEKVLPQTILYKYYERKAEEEVAAAYADELVRCPSCSFPALLDSD
VKRFSCPNPHCRKETCRKCQGLWKEHNGLTCEELAEKDDIKYRTSIEEKMTAARIRKCHKCGTGLIKSEGCNRMSCRCGAQMCYLCRVSI
NGYDHFCQHPRSPGAPCQECSRCSLWTDPTEDDEKLIEEIQKEAEEEQKRKNGENTFKRIGPPLEKPVEKVQRVEALPRPVPQNLPQPQM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SETD2-RNF216


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12211418_17142020.02565.0TUBA1A
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12211418_17142020.02565.0TUBA1A


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSETD2chr3:47125209chr7:5756397ENST00000409792-12212457_25642020.02565.0POLR2A
HgeneSETD2chr3:47125210chr7:5756397ENST00000409792-12212457_25642020.02565.0POLR2A


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SETD2-RNF216


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SETD2-RNF216


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource