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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SETD5-ATG7 (FusionGDB2 ID:80903)

Fusion Gene Summary for SETD5-ATG7

check button Fusion gene summary
Fusion gene informationFusion gene name: SETD5-ATG7
Fusion gene ID: 80903
HgeneTgene
Gene symbol

SETD5

ATG7

Gene ID

55209

10533

Gene nameSET domain containing 5autophagy related 7
Synonyms-APG7-LIKE|APG7L|GSA7
Cytomap

3p25.3

3p25.3

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase SETD5SET domain-containing protein 5ubiquitin-like modifier-activating enzyme ATG7APG7 autophagy 7-likeATG12-activating enzyme E1 ATG7hAGP7ubiquitin-activating enzyme E1-like protein
Modification date2020031320200329
UniProtAcc.

O95352

Ensembl transtripts involved in fusion geneENST00000488236, ENST00000302463, 
ENST00000402198, ENST00000402466, 
ENST00000406341, ENST00000407969, 
ENST00000354449, ENST00000354956, 
ENST00000446450, ENST00000469654, 
Fusion gene scores* DoF score19 X 16 X 7=212812 X 13 X 12=1872
# samples 2321
** MAII scorelog2(23/2128*10)=-3.20979238455681
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(21/1872*10)=-3.15611920191728
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SETD5 [Title/Abstract] AND ATG7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSETD5(9506356)-ATG7(11596285), # samples:3
Anticipated loss of major functional domain due to fusion event.SETD5-ATG7 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SETD5-ATG7 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneATG7

GO:0006497

protein lipidation

12890687

TgeneATG7

GO:0009267

cellular response to starvation

20543840

TgeneATG7

GO:0031401

positive regulation of protein modification process

12890687

TgeneATG7

GO:0071455

cellular response to hyperoxia

20543840


check buttonFusion gene breakpoints across SETD5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATG7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A56Z-01ASETD5chr3

9439661

+ATG7chr3

11596285

+
ChimerDB4BRCATCGA-EW-A6SA-01ASETD5chr3

9506356

-ATG7chr3

11596285

+
ChimerDB4BRCATCGA-EW-A6SA-01ASETD5chr3

9506356

+ATG7chr3

11596285

+


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Fusion Gene ORF analysis for SETD5-ATG7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000488236ENST00000354449SETD5chr3

9506356

+ATG7chr3

11596285

+
3UTR-3CDSENST00000488236ENST00000354956SETD5chr3

9506356

+ATG7chr3

11596285

+
3UTR-3CDSENST00000488236ENST00000446450SETD5chr3

9506356

+ATG7chr3

11596285

+
3UTR-intronENST00000488236ENST00000469654SETD5chr3

9506356

+ATG7chr3

11596285

+
5CDS-intronENST00000302463ENST00000469654SETD5chr3

9506356

+ATG7chr3

11596285

+
5CDS-intronENST00000402198ENST00000469654SETD5chr3

9506356

+ATG7chr3

11596285

+
5CDS-intronENST00000402466ENST00000469654SETD5chr3

9506356

+ATG7chr3

11596285

+
5CDS-intronENST00000406341ENST00000469654SETD5chr3

9506356

+ATG7chr3

11596285

+
5CDS-intronENST00000407969ENST00000469654SETD5chr3

9506356

+ATG7chr3

11596285

+
5UTR-3CDSENST00000402198ENST00000354449SETD5chr3

9439661

+ATG7chr3

11596285

+
5UTR-3CDSENST00000402198ENST00000354956SETD5chr3

9439661

+ATG7chr3

11596285

+
5UTR-3CDSENST00000402198ENST00000446450SETD5chr3

9439661

+ATG7chr3

11596285

+
5UTR-3CDSENST00000402466ENST00000354449SETD5chr3

9439661

+ATG7chr3

11596285

+
5UTR-3CDSENST00000402466ENST00000354956SETD5chr3

9439661

+ATG7chr3

11596285

+
5UTR-3CDSENST00000402466ENST00000446450SETD5chr3

9439661

+ATG7chr3

11596285

+
5UTR-3CDSENST00000406341ENST00000354449SETD5chr3

9439661

+ATG7chr3

11596285

+
5UTR-3CDSENST00000406341ENST00000354956SETD5chr3

9439661

+ATG7chr3

11596285

+
5UTR-3CDSENST00000406341ENST00000446450SETD5chr3

9439661

+ATG7chr3

11596285

+
5UTR-intronENST00000402198ENST00000469654SETD5chr3

9439661

+ATG7chr3

11596285

+
5UTR-intronENST00000402466ENST00000469654SETD5chr3

9439661

+ATG7chr3

11596285

+
5UTR-intronENST00000406341ENST00000469654SETD5chr3

9439661

+ATG7chr3

11596285

+
Frame-shiftENST00000302463ENST00000354449SETD5chr3

9506356

+ATG7chr3

11596285

+
Frame-shiftENST00000302463ENST00000446450SETD5chr3

9506356

+ATG7chr3

11596285

+
Frame-shiftENST00000402198ENST00000354449SETD5chr3

9506356

+ATG7chr3

11596285

+
Frame-shiftENST00000402198ENST00000446450SETD5chr3

9506356

+ATG7chr3

11596285

+
Frame-shiftENST00000402466ENST00000354449SETD5chr3

9506356

+ATG7chr3

11596285

+
Frame-shiftENST00000402466ENST00000446450SETD5chr3

9506356

+ATG7chr3

11596285

+
Frame-shiftENST00000406341ENST00000354449SETD5chr3

9506356

+ATG7chr3

11596285

+
Frame-shiftENST00000406341ENST00000446450SETD5chr3

9506356

+ATG7chr3

11596285

+
Frame-shiftENST00000407969ENST00000354449SETD5chr3

9506356

+ATG7chr3

11596285

+
Frame-shiftENST00000407969ENST00000446450SETD5chr3

9506356

+ATG7chr3

11596285

+
In-frameENST00000302463ENST00000354956SETD5chr3

9506356

+ATG7chr3

11596285

+
In-frameENST00000402198ENST00000354956SETD5chr3

9506356

+ATG7chr3

11596285

+
In-frameENST00000402466ENST00000354956SETD5chr3

9506356

+ATG7chr3

11596285

+
In-frameENST00000406341ENST00000354956SETD5chr3

9506356

+ATG7chr3

11596285

+
In-frameENST00000407969ENST00000354956SETD5chr3

9506356

+ATG7chr3

11596285

+
intron-3CDSENST00000302463ENST00000354449SETD5chr3

9439661

+ATG7chr3

11596285

+
intron-3CDSENST00000302463ENST00000354956SETD5chr3

9439661

+ATG7chr3

11596285

+
intron-3CDSENST00000302463ENST00000446450SETD5chr3

9439661

+ATG7chr3

11596285

+
intron-3CDSENST00000407969ENST00000354449SETD5chr3

9439661

+ATG7chr3

11596285

+
intron-3CDSENST00000407969ENST00000354956SETD5chr3

9439661

+ATG7chr3

11596285

+
intron-3CDSENST00000407969ENST00000446450SETD5chr3

9439661

+ATG7chr3

11596285

+
intron-3CDSENST00000488236ENST00000354449SETD5chr3

9439661

+ATG7chr3

11596285

+
intron-3CDSENST00000488236ENST00000354956SETD5chr3

9439661

+ATG7chr3

11596285

+
intron-3CDSENST00000488236ENST00000446450SETD5chr3

9439661

+ATG7chr3

11596285

+
intron-intronENST00000302463ENST00000469654SETD5chr3

9439661

+ATG7chr3

11596285

+
intron-intronENST00000407969ENST00000469654SETD5chr3

9439661

+ATG7chr3

11596285

+
intron-intronENST00000488236ENST00000469654SETD5chr3

9439661

+ATG7chr3

11596285

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000402198SETD5chr39506356+ENST00000354956ATG7chr311596285+343231594263191921
ENST00000402466SETD5chr39506356+ENST00000354956ATG7chr311596285+347131984263230934
ENST00000406341SETD5chr39506356+ENST00000354956ATG7chr311596285+318729141812946921
ENST00000407969SETD5chr39506356+ENST00000354956ATG7chr311596285+3068279552827940
ENST00000302463SETD5chr39506356+ENST00000354956ATG7chr311596285+306727941962826876

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000402198ENST00000354956SETD5chr39506356+ATG7chr311596285+0.0009217750.99907815
ENST00000402466ENST00000354956SETD5chr39506356+ATG7chr311596285+0.0009953560.99900466
ENST00000406341ENST00000354956SETD5chr39506356+ATG7chr311596285+0.0008571090.9991429
ENST00000407969ENST00000354956SETD5chr39506356+ATG7chr311596285+0.0012064460.9987935
ENST00000302463ENST00000354956SETD5chr39506356+ATG7chr311596285+0.0025968880.9974031

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Fusion Genomic Features for SETD5-ATG7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SETD5chr39506356+ATG7chr311596284+0.0003054530.9996946
SETD5chr39439661+ATG7chr311596284+2.57E-060.9999974
SETD5chr39506356+ATG7chr311596284+0.0003054530.9996946
SETD5chr39439661+ATG7chr311596284+2.57E-060.9999974

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SETD5-ATG7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:9506356/chr3:11596285)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ATG7

O95352

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation. Plays a role in regulating the liver clock and glucose metabolism by mediating the autophagic degradation of CRY1 (clock repressor) in a time-dependent manner (By similarity). {ECO:0000250|UniProtKB:Q9D906, ECO:0000269|PubMed:11096062, ECO:0000269|PubMed:16303767, ECO:0000269|PubMed:22170151}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSETD5chr3:9506356chr3:11596285ENST00000302463+1722269_3908101345.0DomainSET
HgeneSETD5chr3:9506356chr3:11596285ENST00000402198+1823269_3909081443.0DomainSET
HgeneSETD5chr3:9506356chr3:11596285ENST00000402466+1924269_3908101345.0DomainSET
HgeneSETD5chr3:9506356chr3:11596285ENST00000406341+1722269_3909081443.0DomainSET

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSETD5chr3:9506356chr3:11596285ENST00000302463+17221089_14118101345.0Compositional biasNote=Ser-rich
HgeneSETD5chr3:9506356chr3:11596285ENST00000402198+18231089_14119081443.0Compositional biasNote=Ser-rich
HgeneSETD5chr3:9506356chr3:11596285ENST00000402466+19241089_14118101345.0Compositional biasNote=Ser-rich
HgeneSETD5chr3:9506356chr3:11596285ENST00000406341+17221089_14119081443.0Compositional biasNote=Ser-rich
TgeneATG7chr3:9506356chr3:11596285ENST00000354449171915_17693704.0MotifNote=FAP motif
TgeneATG7chr3:9506356chr3:11596285ENST00000354956161815_17666677.0MotifNote=FAP motif
TgeneATG7chr3:9506356chr3:11596285ENST00000446450151715_17613624.0MotifNote=FAP motif


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Fusion Gene Sequence for SETD5-ATG7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>80903_80903_1_SETD5-ATG7_SETD5_chr3_9506356_ENST00000302463_ATG7_chr3_11596285_ENST00000354956_length(transcript)=3067nt_BP=2794nt
GGCAGTACCAGGGATTAGGGTCTGGGCTGGAAAAATCCTGGTGTTTTGAATATGTTCAGGTCCAGTTCAGACTCTTGATCCCACAGCCAC
TTCTTGAGTGAGCCCTGAATCTGTGGAGGCTAGTCCAGCAGTTAATGAGAAGAGCGTGTATTCCACTCATAATTATGGGACCACTCAGAG
GCATGGGTGTCGAGGACTGCCTTATGCTACGATCATCCCTCGTTCTGACCTGAATGGCCTGCCGTCGCCTGTAGAGGAACGCTGTGGAGA
CAGCCCGAACTCTGAAGGAGAAACTGTACCTACCTGGTGTCCTTGTGGTCTTTCTCAGGATGGCTTCCTTCTCAACTGTGACAAGTGCAG
GGGAATGAGCAGGGGGAAGGTTATTAGACTTCATCGGCGGAAGCAGGACAACATATCAGGTGGGGATAGCAGTGCAACAGAAAGCTGGGA
TGAGGAGCTTTCTCCTTCCACTGTGTTGTATACAGCAACACAGCACACACCTACAAGCATCACCTTAACTGTTAGAAGAACCAAACCCAA
GAAGCGGAAAAAGAGTCCAGAAAAGGGTCGTGCAGCACCAAAGACGAAGAAAATCAAGGCATTTCGAGAGGGATCCCGGAAGTCCTTGCG
GATGAAGAATTCTCCCTCTGAAGCACAGAATTTAGATGAGAATACAACTGAGGGCTGGGAAAATCGGATAAGACTATGGACTGACCAGTA
TGAAGAAGCTTTCACTAATCAGTACAGTGCAGATGTACAGAACGCGCTTGAACAACACCTACATTCTAGCAAGGAATTTGTGGGCAAACC
TACTATTTTAGACACTATTAATAAGACTGAATTGGCCTGTAATAACACAGTTATTGGTTCCCAAATGCAGTTACAGCTGGGAAGAGTCAC
TCGTGTTCAAAAGCACCGGAAGATCCTGAGGGCTGCAAGAGATTTGGCTTTGGACACTCTTATAATAGAGTATCGTGGGAAAGTCATGTT
ACGACAGCAATTTGAGGTCAATGGGCATTTCTTCAAAAAACCATACCCCTTTGTGCTCTTCTACTCAAAATTCAATGGTGTAGAGATGTG
TGTGGATGCCCGTACTTTCGGTAATGATGCTCGGTTCATCAGAAGATCATGTACACCAAATGCAGAGGTGCGACACATGATTGCAGATGG
GATGATTCACCTGTGCATCTATGCTGTGTCTGCCATCACCAAGGATGCTGAGGTCACCATAGCATTTGATTATGAGTATAGTAACTGTAA
TTATAAAGTGGACTGTGCCTGTCACAAGGGAAACCGGAATTGTCCTATACAAAAAAGGAATCCTAATGCTACAGAACTGCCACTCCTACC
ACCTCCTCCAAGCCTACCCACCATTGGAGCAGAGACTAGACGTAGAAAAGCACGACGGAAAGAGCTAGAGATGGAGCAGCAGAATGAGGC
TTCAGAGGAGAATAATGACCAGCAATCACAAGAAGTTCCAGAAAAAGTAACTGTATCCAGTGATCATGAGGAAGTAGACAATCCAGAAGA
AAAACCAGAAGAAGAGAAAGAAGAGGTTATAGATGACCAGGAGAACCTAGCTCATAGCAGGAGGACCAGGGAAGATAGAAAGGTAGAAGC
CATCATGCATGCTTTTGAAAACTTAGAGAAAAGAAAGAAGCGGCGGGATCAGCCCTTGGAACAGAGCAACTCTGATGTAGAGATTACTAC
AACCACCTCAGAGACTCCTGTTGGTGAAGAGACAAAAACTGAAGCCCCTGAATCTGAAGTTAGCAACTCTGTTTCAAATGTTACCATCCC
AAGCACCCCACAGAGTGTTGGTGTGAATACCCGGAGGTCTTCCCAAGCAGGGGATATTGCTGCAGAAAAACTAGTCCCCAAGCCACCTCC
AGCAAAGCCTTCTAGGCCCCGGCCGAAGAGTCGAATTTCTCGGTACAGGACCAGTTCAGCCCAAAGACTAAAGCGTCAGAAGCAGGCCAA
TGCACAGCAGGCAGAATTGTCACAAGCTGCCTTGGAAGAGGGAGGAAGTAACAGTTTAGTAACTCCTACTGAAGCTGGAAGTCTAGACAG
TTCAGGAGAAAACAGGCCATTAACAGGGTCTGACCCAACTGTGGTGTCAATTACTGGATCCCATGTCAACCGTGCTGCATCTAAATACCC
CAAAACCAAAAAGTATCTAGTTACAGAATGGTTGAATGACAAAGCAGAGAAGCAAGAGTGCCCTGTTGAGTGCCCTTTACGTATCACAAC
GGATCCAACTGTACTGGCAACGACCCTAAACATGTTACCAGGTCTTATCCATTCCCCGTTAATTTGCACCACCCCCAAACACTACATTCG
CTTTGGCTCACCCTTTATCCCTGAGAGACGTCGAAGGCCCCTTCTGCCTGATGGCACATTCAGCTCCTGTAAGAAGCGCTGGATAAAACA
AGCCTTAGAAGAAGGGATGACTCAAACATCATCTGTACCCCAAGAGACTAGAACTCAGCACCTATACCAAAGCAATGAGAATAGTAGCTC
TTCTAGTATCTGCAAAGACAATGCAGACTTGTTGAGCCCATTAAAGAAATGGAAGTCTCGCTATCTGATGGAGCAGAATGTCACCAAGTT
ACTTCGGCCTCTGTCTCCAGTCACACCACCCCCTCCCAATTCAGGCTCAAAGAGTCCCCAGCTGGCCACACCTGGCTCATCTCACCCAGG
AGAAGAGGAGTGTCGAAATGGATACAGCCTCATGTTTTCACCAGTCACATCTCTTACTACTGCTAGTCGCTGCAACACTCCTCTACAGTT
TGAGATCTGGGACATGAGCGATGATGAGACCATCTGAGATGGCCCCGCTGTGGGGCTGACTTCTCCCCGGCCGCCTGCTGAGGAGCTCTC
CATCGCCAGAGCAGGACTGCTGACCCCAGGCCTGGTGATTCTGGGCCCCTCCTCCATACCCCGAGGTCTGGGATTCCCCCCTCTGCTGCC
CAGGAGTGGCCAGTGTTCGGCGTTGCTCGGGATTCAAGATACCACCAGTTCAGAGCTAAATAATAACCTTGGCCTTGGCCTTGCTATTGA

>80903_80903_1_SETD5-ATG7_SETD5_chr3_9506356_ENST00000302463_ATG7_chr3_11596285_ENST00000354956_length(amino acids)=876AA_BP=
MPYATIIPRSDLNGLPSPVEERCGDSPNSEGETVPTWCPCGLSQDGFLLNCDKCRGMSRGKVIRLHRRKQDNISGGDSSATESWDEELSP
STVLYTATQHTPTSITLTVRRTKPKKRKKSPEKGRAAPKTKKIKAFREGSRKSLRMKNSPSEAQNLDENTTEGWENRIRLWTDQYEEAFT
NQYSADVQNALEQHLHSSKEFVGKPTILDTINKTELACNNTVIGSQMQLQLGRVTRVQKHRKILRAARDLALDTLIIEYRGKVMLRQQFE
VNGHFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARFIRRSCTPNAEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYEYSNCNYKVDC
ACHKGNRNCPIQKRNPNATELPLLPPPPSLPTIGAETRRRKARRKELEMEQQNEASEENNDQQSQEVPEKVTVSSDHEEVDNPEEKPEEE
KEEVIDDQENLAHSRRTREDRKVEAIMHAFENLEKRKKRRDQPLEQSNSDVEITTTTSETPVGEETKTEAPESEVSNSVSNVTIPSTPQS
VGVNTRRSSQAGDIAAEKLVPKPPPAKPSRPRPKSRISRYRTSSAQRLKRQKQANAQQAELSQAALEEGGSNSLVTPTEAGSLDSSGENR
PLTGSDPTVVSITGSHVNRAASKYPKTKKYLVTEWLNDKAEKQECPVECPLRITTDPTVLATTLNMLPGLIHSPLICTTPKHYIRFGSPF
IPERRRRPLLPDGTFSSCKKRWIKQALEEGMTQTSSVPQETRTQHLYQSNENSSSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLRPLS

--------------------------------------------------------------
>80903_80903_2_SETD5-ATG7_SETD5_chr3_9506356_ENST00000402198_ATG7_chr3_11596285_ENST00000354956_length(transcript)=3432nt_BP=3159nt
GCTCAGAGACTCACGCAGCCCCAGTCCCGCCAGTCCGCCAACACAGTAGTGCCGGCCCCCCTCTTTCCCTGGCCCTGCCCCCCCTCCCCG
CCTTTGGCTCGCTCCGCCTTTCTGCCCCCCACCCCCACCTCACGGGTACGGGCCATTCCCGGCCAGGAAACGCCGTGGCGCCGCGTTGGG
CCTAACTCGAGTCCTGCCGCCTCCCGGGAGTGCCGTGCGCCGCAGCCCGGGCCCAGGCCCCGGCAGCGCCTGGGACAAGGTCTTCAGAAC
TACTAGCAGATAATTTGGGGGGACTTCATATTCAGAAGTCTATATAAAGGATTCCTCATGTCCATAACATGTTGGATGAGGCTCTGCAGC
TCACCCCCACTCTCAGAGTGGTCAGTCTCCATTAATTGGACCCCGTGATTTCCAATCTCTGCTGTGTTGGACGTCATGAGCATTGCAATC
CCTCTGGGAGTCACCACATCAGATACATCCTACTCAGATATGGCTGCTGGATCAGACCCTGAATCTGTGGAGGCTAGTCCAGCAGTTAAT
GAGAAGAGCGTGTATTCCACTCATAATTATGGGACCACTCAGAGGCATGGGTGTCGAGGACTGCCTTATGCTACGATCATCCCTCGTTCT
GACCTGAATGGCCTGCCGTCGCCTGTAGAGGAACGCTGTGGAGACAGCCCGAACTCTGAAGGAGAAACTGTACCTACCTGGTGTCCTTGT
GGTCTTTCTCAGGATGGCTTCCTTCTCAACTGTGACAAGTGCAGGGGAATGAGCAGGGGGAAGGTTATTAGACTTCATCGGCGGAAGCAG
GACAACATATCAGGTGGGGATAGCAGTGCAACAGAAAGCTGGGATGAGGAGCTTTCTCCTTCCACTGTGTTGTATACAGCAACACAGCAC
ACACCTACAAGCATCACCTTAACTGTTAGAAGAACCAAACCCAAGAAGCGGAAAAAGAGTCCAGAAAAGGGTCGTGCAGCACCAAAGACG
AAGAAAATCAAGAATTCTCCCTCTGAAGCACAGAATTTAGATGAGAATACAACTGAGGGCTGGGAAAATCGGATAAGACTATGGACTGAC
CAGTATGAAGAAGCTTTCACTAATCAGTACAGTGCAGATGTACAGAACGCGCTTGAACAACACCTACATTCTAGCAAGGAATTTGTGGGC
AAACCTACTATTTTAGACACTATTAATAAGACTGAATTGGCCTGTAATAACACAGTTATTGGTTCCCAAATGCAGTTACAGCTGGGAAGA
GTCACTCGTGTTCAAAAGCACCGGAAGATCCTGAGGGCTGCAAGAGATTTGGCTTTGGACACTCTTATAATAGAGTATCGTGGGAAAGTC
ATGTTACGACAGCAATTTGAGGTCAATGGGCATTTCTTCAAAAAACCATACCCCTTTGTGCTCTTCTACTCAAAATTCAATGGTGTAGAG
ATGTGTGTGGATGCCCGTACTTTCGGTAATGATGCTCGGTTCATCAGAAGATCATGTACACCAAATGCAGAGGTGCGACACATGATTGCA
GATGGGATGATTCACCTGTGCATCTATGCTGTGTCTGCCATCACCAAGGATGCTGAGGTCACCATAGCATTTGATTATGAGTATAGTAAC
TGTAATTATAAAGTGGACTGTGCCTGTCACAAGGGAAACCGGAATTGTCCTATACAAAAAAGGAATCCTAATGCTACAGAACTGCCACTC
CTACCACCTCCTCCAAGCCTACCCACCATTGGAGCAGAGACTAGACGTAGAAAAGCACGACGGAAAGAGCTAGAGATGGAGCAGCAGAAT
GAGGCTTCAGAGGAGAATAATGACCAGCAATCACAAGAAGTTCCAGAAAAAGTAACTGTATCCAGTGATCATGAGGAAGTAGACAATCCA
GAAGAAAAACCAGAAGAAGAGAAAGAAGAGGTTATAGATGACCAGGAGAACCTAGCTCATAGCAGGAGGACCAGGGAAGATAGAAAGGTA
GAAGCCATCATGCATGCTTTTGAAAACTTAGAGAAAAGAAAGAAGCGGCGGGATCAGCCCTTGGAACAGAGCAACTCTGATGTAGAGATT
ACTACAACCACCTCAGAGACTCCTGTTGGTGAAGAGACAAAAACTGAAGCCCCTGAATCTGAAGTTAGCAACTCTGTTTCAAATGTTACC
ATCCCAAGCACCCCACAGAGTGTTGGTGTGAATACCCGGAGGTCTTCCCAAGCAGGGGATATTGCTGCAGAAAAACTAGTCCCCAAGCCA
CCTCCAGCAAAGCCTTCTAGGCCCCGGCCGAAGAGTCGAATTTCTCGGTACAGGACCAGTTCAGCCCAAAGACTAAAGCGTCAGAAGCAG
GCCAATGCACAGCAGGCAGAATTGTCACAAGCTGCCTTGGAAGAGGGAGGAAGTAACAGTTTAGTAACTCCTACTGAAGCTGGAAGTCTA
GACAGTTCAGGAGAAAACAGGCCATTAACAGGGTCTGACCCAACTGTGGTGTCAATTACTGGATCCCATGTCAACCGTGCTGCATCTAAA
TACCCCAAAACCAAAAAGTATCTAGTTACAGAATGGTTGAATGACAAAGCAGAGAAGCAAGAGTGCCCTGTTGAGTGCCCTTTACGTATC
ACAACGGATCCAACTGTACTGGCAACGACCCTAAACATGTTACCAGGTCTTATCCATTCCCCGTTAATTTGCACCACCCCCAAACACTAC
ATTCGCTTTGGCTCACCCTTTATCCCTGAGAGACGTCGAAGGCCCCTTCTGCCTGATGGCACATTCAGCTCCTGTAAGAAGCGCTGGATA
AAACAAGCCTTAGAAGAAGGGATGACTCAAACATCATCTGTACCCCAAGAGACTAGAACTCAGCACCTATACCAAAGCAATGAGAATAGT
AGCTCTTCTAGTATCTGCAAAGACAATGCAGACTTGTTGAGCCCATTAAAGAAATGGAAGTCTCGCTATCTGATGGAGCAGAATGTCACC
AAGTTACTTCGGCCTCTGTCTCCAGTCACACCACCCCCTCCCAATTCAGGCTCAAAGAGTCCCCAGCTGGCCACACCTGGCTCATCTCAC
CCAGGAGAAGAGGAGTGTCGAAATGGATACAGCCTCATGTTTTCACCAGTCACATCTCTTACTACTGCTAGTCGCTGCAACACTCCTCTA
CAGTTTGAGATCTGGGACATGAGCGATGATGAGACCATCTGAGATGGCCCCGCTGTGGGGCTGACTTCTCCCCGGCCGCCTGCTGAGGAG
CTCTCCATCGCCAGAGCAGGACTGCTGACCCCAGGCCTGGTGATTCTGGGCCCCTCCTCCATACCCCGAGGTCTGGGATTCCCCCCTCTG
CTGCCCAGGAGTGGCCAGTGTTCGGCGTTGCTCGGGATTCAAGATACCACCAGTTCAGAGCTAAATAATAACCTTGGCCTTGGCCTTGCT

>80903_80903_2_SETD5-ATG7_SETD5_chr3_9506356_ENST00000402198_ATG7_chr3_11596285_ENST00000354956_length(amino acids)=921AA_BP=
MDVMSIAIPLGVTTSDTSYSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQRHGCRGLPYATIIPRSDLNGLPSPVEERCGDSPNSEGE
TVPTWCPCGLSQDGFLLNCDKCRGMSRGKVIRLHRRKQDNISGGDSSATESWDEELSPSTVLYTATQHTPTSITLTVRRTKPKKRKKSPE
KGRAAPKTKKIKNSPSEAQNLDENTTEGWENRIRLWTDQYEEAFTNQYSADVQNALEQHLHSSKEFVGKPTILDTINKTELACNNTVIGS
QMQLQLGRVTRVQKHRKILRAARDLALDTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARFIRRSCTPN
AEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQKRNPNATELPLLPPPPSLPTIGAETRRRKARRK
ELEMEQQNEASEENNDQQSQEVPEKVTVSSDHEEVDNPEEKPEEEKEEVIDDQENLAHSRRTREDRKVEAIMHAFENLEKRKKRRDQPLE
QSNSDVEITTTTSETPVGEETKTEAPESEVSNSVSNVTIPSTPQSVGVNTRRSSQAGDIAAEKLVPKPPPAKPSRPRPKSRISRYRTSSA
QRLKRQKQANAQQAELSQAALEEGGSNSLVTPTEAGSLDSSGENRPLTGSDPTVVSITGSHVNRAASKYPKTKKYLVTEWLNDKAEKQEC
PVECPLRITTDPTVLATTLNMLPGLIHSPLICTTPKHYIRFGSPFIPERRRRPLLPDGTFSSCKKRWIKQALEEGMTQTSSVPQETRTQH
LYQSNENSSSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLRPLSPVTPPPPNSGSKSPQLATPGSSHPGEEECRNGYSLMFSPVTSLTT

--------------------------------------------------------------
>80903_80903_3_SETD5-ATG7_SETD5_chr3_9506356_ENST00000402466_ATG7_chr3_11596285_ENST00000354956_length(transcript)=3471nt_BP=3198nt
GCTCAGAGACTCACGCAGCCCCAGTCCCGCCAGTCCGCCAACACAGTAGTGCCGGCCCCCCTCTTTCCCTGGCCCTGCCCCCCCTCCCCG
CCTTTGGCTCGCTCCGCCTTTCTGCCCCCCACCCCCACCTCACGGGTACGGGCCATTCCCGGCCAGGAAACGCCGTGGCGCCGCGTTGGG
CCTAACTCGAGTCCTGCCGCCTCCCGGGAGTGCCGTGCGCCGCAGCCCGGGCCCAGGCCCCGGCAGCGCCTGGGACAAGGTCTTCAGAAC
TACTAGCAGATAATTTGGGGGGACTTCATATTCAGAAGTCTATATAAAGGATTCCTCATGTCCATAACATGTTGGATGAGGCTCTGCAGC
TCACCCCCACTCTCAGAGTGGTCAGTCTCCATTAATTGGACCCCGTGATTTCCAATCTCTGCTGTGTTGGACGTCATGAGCATTGCAATC
CCTCTGGGAGTCACCACATCAGATACATCCTACTCAGATATGGCTGCTGGATCAGACCCTGAATCTGTGGAGGCTAGTCCAGCAGTTAAT
GAGAAGAGCGTGTATTCCACTCATAATTATGGGACCACTCAGAGGCATGGGTGTCGAGGACTGCCTTATGCTACGATCATCCCTCGTTCT
GACCTGAATGGCCTGCCGTCGCCTGTAGAGGAACGCTGTGGAGACAGCCCGAACTCTGAAGGAGAAACTGTACCTACCTGGTGTCCTTGT
GGTCTTTCTCAGGATGGCTTCCTTCTCAACTGTGACAAGTGCAGGGGAATGAGCAGGGGGAAGGTTATTAGACTTCATCGGCGGAAGCAG
GACAACATATCAGGTGGGGATAGCAGTGCAACAGAAAGCTGGGATGAGGAGCTTTCTCCTTCCACTGTGTTGTATACAGCAACACAGCAC
ACACCTACAAGCATCACCTTAACTGTTAGAAGAACCAAACCCAAGAAGCGGAAAAAGAGTCCAGAAAAGGGTCGTGCAGCACCAAAGACG
AAGAAAATCAAGGCATTTCGAGAGGGATCCCGGAAGTCCTTGCGGATGAAGAATTCTCCCTCTGAAGCACAGAATTTAGATGAGAATACA
ACTGAGGGCTGGGAAAATCGGATAAGACTATGGACTGACCAGTATGAAGAAGCTTTCACTAATCAGTACAGTGCAGATGTACAGAACGCG
CTTGAACAACACCTACATTCTAGCAAGGAATTTGTGGGCAAACCTACTATTTTAGACACTATTAATAAGACTGAATTGGCCTGTAATAAC
ACAGTTATTGGTTCCCAAATGCAGTTACAGCTGGGAAGAGTCACTCGTGTTCAAAAGCACCGGAAGATCCTGAGGGCTGCAAGAGATTTG
GCTTTGGACACTCTTATAATAGAGTATCGTGGGAAAGTCATGTTACGACAGCAATTTGAGGTCAATGGGCATTTCTTCAAAAAACCATAC
CCCTTTGTGCTCTTCTACTCAAAATTCAATGGTGTAGAGATGTGTGTGGATGCCCGTACTTTCGGTAATGATGCTCGGTTCATCAGAAGA
TCATGTACACCAAATGCAGAGGTGCGACACATGATTGCAGATGGGATGATTCACCTGTGCATCTATGCTGTGTCTGCCATCACCAAGGAT
GCTGAGGTCACCATAGCATTTGATTATGAGTATAGTAACTGTAATTATAAAGTGGACTGTGCCTGTCACAAGGGAAACCGGAATTGTCCT
ATACAAAAAAGGAATCCTAATGCTACAGAACTGCCACTCCTACCACCTCCTCCAAGCCTACCCACCATTGGAGCAGAGACTAGACGTAGA
AAAGCACGACGGAAAGAGCTAGAGATGGAGCAGCAGAATGAGGCTTCAGAGGAGAATAATGACCAGCAATCACAAGAAGTTCCAGAAAAA
GTAACTGTATCCAGTGATCATGAGGAAGTAGACAATCCAGAAGAAAAACCAGAAGAAGAGAAAGAAGAGGTTATAGATGACCAGGAGAAC
CTAGCTCATAGCAGGAGGACCAGGGAAGATAGAAAGGTAGAAGCCATCATGCATGCTTTTGAAAACTTAGAGAAAAGAAAGAAGCGGCGG
GATCAGCCCTTGGAACAGAGCAACTCTGATGTAGAGATTACTACAACCACCTCAGAGACTCCTGTTGGTGAAGAGACAAAAACTGAAGCC
CCTGAATCTGAAGTTAGCAACTCTGTTTCAAATGTTACCATCCCAAGCACCCCACAGAGTGTTGGTGTGAATACCCGGAGGTCTTCCCAA
GCAGGGGATATTGCTGCAGAAAAACTAGTCCCCAAGCCACCTCCAGCAAAGCCTTCTAGGCCCCGGCCGAAGAGTCGAATTTCTCGGTAC
AGGACCAGTTCAGCCCAAAGACTAAAGCGTCAGAAGCAGGCCAATGCACAGCAGGCAGAATTGTCACAAGCTGCCTTGGAAGAGGGAGGA
AGTAACAGTTTAGTAACTCCTACTGAAGCTGGAAGTCTAGACAGTTCAGGAGAAAACAGGCCATTAACAGGGTCTGACCCAACTGTGGTG
TCAATTACTGGATCCCATGTCAACCGTGCTGCATCTAAATACCCCAAAACCAAAAAGTATCTAGTTACAGAATGGTTGAATGACAAAGCA
GAGAAGCAAGAGTGCCCTGTTGAGTGCCCTTTACGTATCACAACGGATCCAACTGTACTGGCAACGACCCTAAACATGTTACCAGGTCTT
ATCCATTCCCCGTTAATTTGCACCACCCCCAAACACTACATTCGCTTTGGCTCACCCTTTATCCCTGAGAGACGTCGAAGGCCCCTTCTG
CCTGATGGCACATTCAGCTCCTGTAAGAAGCGCTGGATAAAACAAGCCTTAGAAGAAGGGATGACTCAAACATCATCTGTACCCCAAGAG
ACTAGAACTCAGCACCTATACCAAAGCAATGAGAATAGTAGCTCTTCTAGTATCTGCAAAGACAATGCAGACTTGTTGAGCCCATTAAAG
AAATGGAAGTCTCGCTATCTGATGGAGCAGAATGTCACCAAGTTACTTCGGCCTCTGTCTCCAGTCACACCACCCCCTCCCAATTCAGGC
TCAAAGAGTCCCCAGCTGGCCACACCTGGCTCATCTCACCCAGGAGAAGAGGAGTGTCGAAATGGATACAGCCTCATGTTTTCACCAGTC
ACATCTCTTACTACTGCTAGTCGCTGCAACACTCCTCTACAGTTTGAGATCTGGGACATGAGCGATGATGAGACCATCTGAGATGGCCCC
GCTGTGGGGCTGACTTCTCCCCGGCCGCCTGCTGAGGAGCTCTCCATCGCCAGAGCAGGACTGCTGACCCCAGGCCTGGTGATTCTGGGC
CCCTCCTCCATACCCCGAGGTCTGGGATTCCCCCCTCTGCTGCCCAGGAGTGGCCAGTGTTCGGCGTTGCTCGGGATTCAAGATACCACC

>80903_80903_3_SETD5-ATG7_SETD5_chr3_9506356_ENST00000402466_ATG7_chr3_11596285_ENST00000354956_length(amino acids)=934AA_BP=
MDVMSIAIPLGVTTSDTSYSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQRHGCRGLPYATIIPRSDLNGLPSPVEERCGDSPNSEGE
TVPTWCPCGLSQDGFLLNCDKCRGMSRGKVIRLHRRKQDNISGGDSSATESWDEELSPSTVLYTATQHTPTSITLTVRRTKPKKRKKSPE
KGRAAPKTKKIKAFREGSRKSLRMKNSPSEAQNLDENTTEGWENRIRLWTDQYEEAFTNQYSADVQNALEQHLHSSKEFVGKPTILDTIN
KTELACNNTVIGSQMQLQLGRVTRVQKHRKILRAARDLALDTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLFYSKFNGVEMCVDARTFG
NDARFIRRSCTPNAEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQKRNPNATELPLLPPPPSLPT
IGAETRRRKARRKELEMEQQNEASEENNDQQSQEVPEKVTVSSDHEEVDNPEEKPEEEKEEVIDDQENLAHSRRTREDRKVEAIMHAFEN
LEKRKKRRDQPLEQSNSDVEITTTTSETPVGEETKTEAPESEVSNSVSNVTIPSTPQSVGVNTRRSSQAGDIAAEKLVPKPPPAKPSRPR
PKSRISRYRTSSAQRLKRQKQANAQQAELSQAALEEGGSNSLVTPTEAGSLDSSGENRPLTGSDPTVVSITGSHVNRAASKYPKTKKYLV
TEWLNDKAEKQECPVECPLRITTDPTVLATTLNMLPGLIHSPLICTTPKHYIRFGSPFIPERRRRPLLPDGTFSSCKKRWIKQALEEGMT
QTSSVPQETRTQHLYQSNENSSSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLRPLSPVTPPPPNSGSKSPQLATPGSSHPGEEECRNG

--------------------------------------------------------------
>80903_80903_4_SETD5-ATG7_SETD5_chr3_9506356_ENST00000406341_ATG7_chr3_11596285_ENST00000354956_length(transcript)=3187nt_BP=2914nt
CTCGAGTCCTGCCGCCTCCCGGGAGTGCCGTGCGCCGCAGCCCGGGCCCAGGCCCCGGCAGCGCCTGGGACAAGGATTCCTCATGTCCAT
AACATGTTGGATGAGGCTCTGCAGCTCACCCCCACTCTCAGAGTGGTCAGTCTCCATTAATTGGACCCCGTGATTTCCAATCTCTGCTGT
GTTGGACGTCATGAGCATTGCAATCCCTCTGGGAGTCACCACATCAGATACATCCTACTCAGATATGGCTGCTGGATCAGACCCTGAATC
TGTGGAGGCTAGTCCAGCAGTTAATGAGAAGAGCGTGTATTCCACTCATAATTATGGGACCACTCAGAGGCATGGGTGTCGAGGACTGCC
TTATGCTACGATCATCCCTCGTTCTGACCTGAATGGCCTGCCGTCGCCTGTAGAGGAACGCTGTGGAGACAGCCCGAACTCTGAAGGAGA
AACTGTACCTACCTGGTGTCCTTGTGGTCTTTCTCAGGATGGCTTCCTTCTCAACTGTGACAAGTGCAGGGGAATGAGCAGGGGGAAGGT
TATTAGACTTCATCGGCGGAAGCAGGACAACATATCAGGTGGGGATAGCAGTGCAACAGAAAGCTGGGATGAGGAGCTTTCTCCTTCCAC
TGTGTTGTATACAGCAACACAGCACACACCTACAAGCATCACCTTAACTGTTAGAAGAACCAAACCCAAGAAGCGGAAAAAGAGTCCAGA
AAAGGGTCGTGCAGCACCAAAGACGAAGAAAATCAAGAATTCTCCCTCTGAAGCACAGAATTTAGATGAGAATACAACTGAGGGCTGGGA
AAATCGGATAAGACTATGGACTGACCAGTATGAAGAAGCTTTCACTAATCAGTACAGTGCAGATGTACAGAACGCGCTTGAACAACACCT
ACATTCTAGCAAGGAATTTGTGGGCAAACCTACTATTTTAGACACTATTAATAAGACTGAATTGGCCTGTAATAACACAGTTATTGGTTC
CCAAATGCAGTTACAGCTGGGAAGAGTCACTCGTGTTCAAAAGCACCGGAAGATCCTGAGGGCTGCAAGAGATTTGGCTTTGGACACTCT
TATAATAGAGTATCGTGGGAAAGTCATGTTACGACAGCAATTTGAGGTCAATGGGCATTTCTTCAAAAAACCATACCCCTTTGTGCTCTT
CTACTCAAAATTCAATGGTGTAGAGATGTGTGTGGATGCCCGTACTTTCGGTAATGATGCTCGGTTCATCAGAAGATCATGTACACCAAA
TGCAGAGGTGCGACACATGATTGCAGATGGGATGATTCACCTGTGCATCTATGCTGTGTCTGCCATCACCAAGGATGCTGAGGTCACCAT
AGCATTTGATTATGAGTATAGTAACTGTAATTATAAAGTGGACTGTGCCTGTCACAAGGGAAACCGGAATTGTCCTATACAAAAAAGGAA
TCCTAATGCTACAGAACTGCCACTCCTACCACCTCCTCCAAGCCTACCCACCATTGGAGCAGAGACTAGACGTAGAAAAGCACGACGGAA
AGAGCTAGAGATGGAGCAGCAGAATGAGGCTTCAGAGGAGAATAATGACCAGCAATCACAAGAAGTTCCAGAAAAAGTAACTGTATCCAG
TGATCATGAGGAAGTAGACAATCCAGAAGAAAAACCAGAAGAAGAGAAAGAAGAGGTTATAGATGACCAGGAGAACCTAGCTCATAGCAG
GAGGACCAGGGAAGATAGAAAGGTAGAAGCCATCATGCATGCTTTTGAAAACTTAGAGAAAAGAAAGAAGCGGCGGGATCAGCCCTTGGA
ACAGAGCAACTCTGATGTAGAGATTACTACAACCACCTCAGAGACTCCTGTTGGTGAAGAGACAAAAACTGAAGCCCCTGAATCTGAAGT
TAGCAACTCTGTTTCAAATGTTACCATCCCAAGCACCCCACAGAGTGTTGGTGTGAATACCCGGAGGTCTTCCCAAGCAGGGGATATTGC
TGCAGAAAAACTAGTCCCCAAGCCACCTCCAGCAAAGCCTTCTAGGCCCCGGCCGAAGAGTCGAATTTCTCGGTACAGGACCAGTTCAGC
CCAAAGACTAAAGCGTCAGAAGCAGGCCAATGCACAGCAGGCAGAATTGTCACAAGCTGCCTTGGAAGAGGGAGGAAGTAACAGTTTAGT
AACTCCTACTGAAGCTGGAAGTCTAGACAGTTCAGGAGAAAACAGGCCATTAACAGGGTCTGACCCAACTGTGGTGTCAATTACTGGATC
CCATGTCAACCGTGCTGCATCTAAATACCCCAAAACCAAAAAGTATCTAGTTACAGAATGGTTGAATGACAAAGCAGAGAAGCAAGAGTG
CCCTGTTGAGTGCCCTTTACGTATCACAACGGATCCAACTGTACTGGCAACGACCCTAAACATGTTACCAGGTCTTATCCATTCCCCGTT
AATTTGCACCACCCCCAAACACTACATTCGCTTTGGCTCACCCTTTATCCCTGAGAGACGTCGAAGGCCCCTTCTGCCTGATGGCACATT
CAGCTCCTGTAAGAAGCGCTGGATAAAACAAGCCTTAGAAGAAGGGATGACTCAAACATCATCTGTACCCCAAGAGACTAGAACTCAGCA
CCTATACCAAAGCAATGAGAATAGTAGCTCTTCTAGTATCTGCAAAGACAATGCAGACTTGTTGAGCCCATTAAAGAAATGGAAGTCTCG
CTATCTGATGGAGCAGAATGTCACCAAGTTACTTCGGCCTCTGTCTCCAGTCACACCACCCCCTCCCAATTCAGGCTCAAAGAGTCCCCA
GCTGGCCACACCTGGCTCATCTCACCCAGGAGAAGAGGAGTGTCGAAATGGATACAGCCTCATGTTTTCACCAGTCACATCTCTTACTAC
TGCTAGTCGCTGCAACACTCCTCTACAGTTTGAGATCTGGGACATGAGCGATGATGAGACCATCTGAGATGGCCCCGCTGTGGGGCTGAC
TTCTCCCCGGCCGCCTGCTGAGGAGCTCTCCATCGCCAGAGCAGGACTGCTGACCCCAGGCCTGGTGATTCTGGGCCCCTCCTCCATACC
CCGAGGTCTGGGATTCCCCCCTCTGCTGCCCAGGAGTGGCCAGTGTTCGGCGTTGCTCGGGATTCAAGATACCACCAGTTCAGAGCTAAA

>80903_80903_4_SETD5-ATG7_SETD5_chr3_9506356_ENST00000406341_ATG7_chr3_11596285_ENST00000354956_length(amino acids)=921AA_BP=
MDVMSIAIPLGVTTSDTSYSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQRHGCRGLPYATIIPRSDLNGLPSPVEERCGDSPNSEGE
TVPTWCPCGLSQDGFLLNCDKCRGMSRGKVIRLHRRKQDNISGGDSSATESWDEELSPSTVLYTATQHTPTSITLTVRRTKPKKRKKSPE
KGRAAPKTKKIKNSPSEAQNLDENTTEGWENRIRLWTDQYEEAFTNQYSADVQNALEQHLHSSKEFVGKPTILDTINKTELACNNTVIGS
QMQLQLGRVTRVQKHRKILRAARDLALDTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLFYSKFNGVEMCVDARTFGNDARFIRRSCTPN
AEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQKRNPNATELPLLPPPPSLPTIGAETRRRKARRK
ELEMEQQNEASEENNDQQSQEVPEKVTVSSDHEEVDNPEEKPEEEKEEVIDDQENLAHSRRTREDRKVEAIMHAFENLEKRKKRRDQPLE
QSNSDVEITTTTSETPVGEETKTEAPESEVSNSVSNVTIPSTPQSVGVNTRRSSQAGDIAAEKLVPKPPPAKPSRPRPKSRISRYRTSSA
QRLKRQKQANAQQAELSQAALEEGGSNSLVTPTEAGSLDSSGENRPLTGSDPTVVSITGSHVNRAASKYPKTKKYLVTEWLNDKAEKQEC
PVECPLRITTDPTVLATTLNMLPGLIHSPLICTTPKHYIRFGSPFIPERRRRPLLPDGTFSSCKKRWIKQALEEGMTQTSSVPQETRTQH
LYQSNENSSSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLRPLSPVTPPPPNSGSKSPQLATPGSSHPGEEECRNGYSLMFSPVTSLTT

--------------------------------------------------------------
>80903_80903_5_SETD5-ATG7_SETD5_chr3_9506356_ENST00000407969_ATG7_chr3_11596285_ENST00000354956_length(transcript)=3068nt_BP=2795nt
CTGTGTTGGACGTCATGAGCATTGCAATCCCTCTGGGAGTCACCACATCAGATACATCCTACTCAGATATGGCTGCTGGATCAGACCCTG
AATCTGTGGAGGCTAGTCCAGCAGTTAATGAGAAGAGCGTGTATTCCACTCATAATTATGGGACCACTCAGAGGCATGGGTGTCGAGGAC
TGCCTTATGCTGATCATAATTACGGAGCCCCTCCTCCTCCGACACCTCCTGCTTCTCCCCCTGTCCAGACGATCATCCCTCGTTCTGACC
TGAATGGCCTGCCGTCGCCTGTAGAGGAACGCTGTGGAGACAGCCCGAACTCTGAAGGAGAAACTGTACCTACCTGGTGTCCTTGTGGTC
TTTCTCAGGATGGCTTCCTTCTCAACTGTGACAAGTGCAGGGGAATGAGCAGGGGGAAGGTTATTAGACTTCATCGGCGGAAGCAGGACA
ACATATCAGGTGGGGATAGCAGTGCAACAGAAAGCTGGGATGAGGAGCTTTCTCCTTCCACTGTGTTGTATACAGCAACACAGCACACAC
CTACAAGCATCACCTTAACTGTTAGAAGAACCAAACCCAAGAAGCGGAAAAAGAGTCCAGAAAAGGGTCGTGCAGCACCAAAGACGAAGA
AAATCAAGAATTCTCCCTCTGAAGCACAGAATTTAGATGAGAATACAACTGAGGGCTGGGAAAATCGGATAAGACTATGGACTGACCAGT
ATGAAGAAGCTTTCACTAATCAGTACAGTGCAGATGTACAGAACGCGCTTGAACAACACCTACATTCTAGCAAGGAATTTGTGGGCAAAC
CTACTATTTTAGACACTATTAATAAGACTGAATTGGCCTGTAATAACACAGTTATTGGTTCCCAAATGCAGTTACAGCTGGGAAGAGTCA
CTCGTGTTCAAAAGCACCGGAAGATCCTGAGGGCTGCAAGAGATTTGGCTTTGGACACTCTTATAATAGAGTATCGTGGGAAAGTCATGT
TACGACAGCAATTTGAGGTCAATGGGCATTTCTTCAAAAAACCATACCCCTTTGTGCTCTTCTACTCAAAATTCAATGGTGTAGAGATGT
GTGTGGATGCCCGTACTTTCGGTAATGATGCTCGGTTCATCAGAAGATCATGTACACCAAATGCAGAGGTGCGACACATGATTGCAGATG
GGATGATTCACCTGTGCATCTATGCTGTGTCTGCCATCACCAAGGATGCTGAGGTCACCATAGCATTTGATTATGAGTATAGTAACTGTA
ATTATAAAGTGGACTGTGCCTGTCACAAGGGAAACCGGAATTGTCCTATACAAAAAAGGAATCCTAATGCTACAGAACTGCCACTCCTAC
CACCTCCTCCAAGCCTACCCACCATTGGAGCAGAGACTAGACGTAGAAAAGCACGACGGAAAGAGCTAGAGATGGAGCAGCAGAATGAGG
CTTCAGAGGAGAATAATGACCAGCAATCACAAGAAGTTCCAGAAAAAGTAACTGTATCCAGTGATCATGAGGAAGTAGACAATCCAGAAG
AAAAACCAGAAGAAGAGAAAGAAGAGGTTATAGATGACCAGGAGAACCTAGCTCATAGCAGGAGGACCAGGGAAGATAGAAAGGTAGAAG
CCATCATGCATGCTTTTGAAAACTTAGAGAAAAGAAAGAAGCGGCGGGATCAGCCCTTGGAACAGAGCAACTCTGATGTAGAGATTACTA
CAACCACCTCAGAGACTCCTGTTGGTGAAGAGACAAAAACTGAAGCCCCTGAATCTGAAGTTAGCAACTCTGTTTCAAATGTTACCATCC
CAAGCACCCCACAGAGTGTTGGTGTGAATACCCGGAGGTCTTCCCAAGCAGGGGATATTGCTGCAGAAAAACTAGTCCCCAAGCCACCTC
CAGCAAAGCCTTCTAGGCCCCGGCCGAAGAGTCGAATTTCTCGGTACAGGACCAGTTCAGCCCAAAGACTAAAGCGTCAGAAGCAGGCCA
ATGCACAGCAGGCAGAATTGTCACAAGCTGCCTTGGAAGAGGGAGGAAGTAACAGTTTAGTAACTCCTACTGAAGCTGGAAGTCTAGACA
GTTCAGGAGAAAACAGGCCATTAACAGGGTCTGACCCAACTGTGGTGTCAATTACTGGATCCCATGTCAACCGTGCTGCATCTAAATACC
CCAAAACCAAAAAGTATCTAGTTACAGAATGGTTGAATGACAAAGCAGAGAAGCAAGAGTGCCCTGTTGAGTGCCCTTTACGTATCACAA
CGGATCCAACTGTACTGGCAACGACCCTAAACATGTTACCAGGTCTTATCCATTCCCCGTTAATTTGCACCACCCCCAAACACTACATTC
GCTTTGGCTCACCCTTTATCCCTGAGAGACGTCGAAGGCCCCTTCTGCCTGATGGCACATTCAGCTCCTGTAAGAAGCGCTGGATAAAAC
AAGCCTTAGAAGAAGGGATGACTCAAACATCATCTGTACCCCAAGAGACTAGAACTCAGCACCTATACCAAAGCAATGAGAATAGTAGCT
CTTCTAGTATCTGCAAAGACAATGCAGACTTGTTGAGCCCATTAAAGAAATGGAAGTCTCGCTATCTGATGGAGCAGAATGTCACCAAGT
TACTTCGGCCTCTGTCTCCAGTCACACCACCCCCTCCCAATTCAGGCTCAAAGAGTCCCCAGCTGGCCACACCTGGCTCATCTCACCCAG
GAGAAGAGGAGTGTCGAAATGGATACAGCCTCATGTTTTCACCAGTCACATCTCTTACTACTGCTAGTCGCTGCAACACTCCTCTACAGT
TTGAGATCTGGGACATGAGCGATGATGAGACCATCTGAGATGGCCCCGCTGTGGGGCTGACTTCTCCCCGGCCGCCTGCTGAGGAGCTCT
CCATCGCCAGAGCAGGACTGCTGACCCCAGGCCTGGTGATTCTGGGCCCCTCCTCCATACCCCGAGGTCTGGGATTCCCCCCTCTGCTGC
CCAGGAGTGGCCAGTGTTCGGCGTTGCTCGGGATTCAAGATACCACCAGTTCAGAGCTAAATAATAACCTTGGCCTTGGCCTTGCTATTG

>80903_80903_5_SETD5-ATG7_SETD5_chr3_9506356_ENST00000407969_ATG7_chr3_11596285_ENST00000354956_length(amino acids)=940AA_BP=
MDVMSIAIPLGVTTSDTSYSDMAAGSDPESVEASPAVNEKSVYSTHNYGTTQRHGCRGLPYADHNYGAPPPPTPPASPPVQTIIPRSDLN
GLPSPVEERCGDSPNSEGETVPTWCPCGLSQDGFLLNCDKCRGMSRGKVIRLHRRKQDNISGGDSSATESWDEELSPSTVLYTATQHTPT
SITLTVRRTKPKKRKKSPEKGRAAPKTKKIKNSPSEAQNLDENTTEGWENRIRLWTDQYEEAFTNQYSADVQNALEQHLHSSKEFVGKPT
ILDTINKTELACNNTVIGSQMQLQLGRVTRVQKHRKILRAARDLALDTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLFYSKFNGVEMCV
DARTFGNDARFIRRSCTPNAEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYEYSNCNYKVDCACHKGNRNCPIQKRNPNATELPLLPP
PPSLPTIGAETRRRKARRKELEMEQQNEASEENNDQQSQEVPEKVTVSSDHEEVDNPEEKPEEEKEEVIDDQENLAHSRRTREDRKVEAI
MHAFENLEKRKKRRDQPLEQSNSDVEITTTTSETPVGEETKTEAPESEVSNSVSNVTIPSTPQSVGVNTRRSSQAGDIAAEKLVPKPPPA
KPSRPRPKSRISRYRTSSAQRLKRQKQANAQQAELSQAALEEGGSNSLVTPTEAGSLDSSGENRPLTGSDPTVVSITGSHVNRAASKYPK
TKKYLVTEWLNDKAEKQECPVECPLRITTDPTVLATTLNMLPGLIHSPLICTTPKHYIRFGSPFIPERRRRPLLPDGTFSSCKKRWIKQA
LEEGMTQTSSVPQETRTQHLYQSNENSSSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLRPLSPVTPPPPNSGSKSPQLATPGSSHPGE

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Fusion Gene PPI Analysis for SETD5-ATG7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SETD5-ATG7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SETD5-ATG7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource