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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SETD6-IFT172 (FusionGDB2 ID:80924)

Fusion Gene Summary for SETD6-IFT172

Fusion gene summary

Fusion gene information	Fusion gene name: SETD6-IFT172
	Fusion gene ID: 80924
		Hgene	Tgene
	Gene symbol	SETD6	IFT172
	Gene ID	79918	26160
	Gene name	SET domain containing 6, protein lysine methyltransferase	intraflagellar transport 172
	Synonyms	-	BBS20\|NPHP17\|RP71\|SLB\|SRTD10\|osm-1\|wim
	Cytomap	16q21	2p23.3
	Type of gene	protein-coding	protein-coding
	Description	N-lysine methyltransferase SETD6SET domain containing 6SET domain-containing protein 6	intraflagellar transport protein 172 homologintraflagellar transport 172 homologselective LIM binding factor homologwimple homolog
	Modification date	20200313	20200320
	UniProtAcc	.	Q9UG01
	Ensembl transtripts involved in fusion gene	ENST00000418480, ENST00000219315, ENST00000310682, ENST00000394266,	ENST00000260570, ENST00000359466, ENST00000416524,
Fusion gene scores	* DoF score	3 X 4 X 2=24	3 X 6 X 3=54
	# samples	4	6
	** MAII score	log2(4/24*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/54*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SETD6 [Title/Abstract] AND IFT172 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SETD6(58550832)-IFT172(27672963), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SETD6	GO:0018026	peptidyl-lysine monomethylation	21131967
Hgene	SETD6	GO:0034968	histone lysine methylation	23324626
Tgene	IFT172	GO:0060271	cilium assembly	24140113

Fusion gene breakpoints across SETD6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IFT172 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-21-5786	SETD6	chr16	58550832	+	IFT172	chr2	27672963	-

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Fusion Gene ORF analysis for SETD6-IFT172

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000418480	ENST00000260570	SETD6	chr16	58550832	+	IFT172	chr2	27672963	-
3UTR-intron	ENST00000418480	ENST00000359466	SETD6	chr16	58550832	+	IFT172	chr2	27672963	-
3UTR-intron	ENST00000418480	ENST00000416524	SETD6	chr16	58550832	+	IFT172	chr2	27672963	-
5CDS-intron	ENST00000219315	ENST00000359466	SETD6	chr16	58550832	+	IFT172	chr2	27672963	-
5CDS-intron	ENST00000219315	ENST00000416524	SETD6	chr16	58550832	+	IFT172	chr2	27672963	-
5CDS-intron	ENST00000310682	ENST00000359466	SETD6	chr16	58550832	+	IFT172	chr2	27672963	-
5CDS-intron	ENST00000310682	ENST00000416524	SETD6	chr16	58550832	+	IFT172	chr2	27672963	-
5CDS-intron	ENST00000394266	ENST00000359466	SETD6	chr16	58550832	+	IFT172	chr2	27672963	-
5CDS-intron	ENST00000394266	ENST00000416524	SETD6	chr16	58550832	+	IFT172	chr2	27672963	-
In-frame	ENST00000219315	ENST00000260570	SETD6	chr16	58550832	+	IFT172	chr2	27672963	-
In-frame	ENST00000310682	ENST00000260570	SETD6	chr16	58550832	+	IFT172	chr2	27672963	-
In-frame	ENST00000394266	ENST00000260570	SETD6	chr16	58550832	+	IFT172	chr2	27672963	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000310682	SETD6	chr16	58550832	+	ENST00000260570	IFT172	chr2	27672963	-	2139	779	59	2077	672
ENST00000394266	SETD6	chr16	58550832	+	ENST00000260570	IFT172	chr2	27672963	-	2001	641	56	1939	627
ENST00000219315	SETD6	chr16	58550832	+	ENST00000260570	IFT172	chr2	27672963	-	2202	842	50	2140	696

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000310682	ENST00000260570	SETD6	chr16	58550832	+	IFT172	chr2	27672963	-	0.008744586	0.9912554
ENST00000394266	ENST00000260570	SETD6	chr16	58550832	+	IFT172	chr2	27672963	-	0.009192612	0.99080735
ENST00000219315	ENST00000260570	SETD6	chr16	58550832	+	IFT172	chr2	27672963	-	0.009767945	0.99023205

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Fusion Genomic Features for SETD6-IFT172

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SETD6-IFT172

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:58550832/chr2:27672963)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	IFT172 Q9UG01
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Required for the maintenance and formation of cilia. Plays an indirect role in hedgehog (Hh) signaling, cilia being required for all activity of the hedgehog pathway (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

1345_1378

1317

1750.0

Repeat

Note=TPR 11

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

1411_1445

1317

1750.0

Repeat

Note=TPR 12

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

1447_1477

1317

1750.0

Repeat

Note=TPR 13

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

1574_1607

1317

1750.0

Repeat

Note=TPR 14

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SETD6

chr16:58550832

chr2:27672963

ENST00000219315

60_286

264

474.0

Domain

SET

Hgene

SETD6

chr16:58550832

chr2:27672963

ENST00000310682

60_286

240

450.0

Domain

SET

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

1042_1075

1317

1750.0

Repeat

Note=TPR 8

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

110_148

1317

1750.0

Repeat

Note=WD 3

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

1142_1175

1317

1750.0

Repeat

Note=TPR 9

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

1276_1309

1317

1750.0

Repeat

Note=TPR 10

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

14_53

1317

1750.0

Repeat

Note=WD 1

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

150_191

1317

1750.0

Repeat

Note=WD 4

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

195_233

1317

1750.0

Repeat

Note=WD 5

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

238_278

1317

1750.0

Repeat

Note=WD 6

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

284_323

1317

1750.0

Repeat

Note=WD 7

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

483_520

1317

1750.0

Repeat

Note=WD 8

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

521_559

1317

1750.0

Repeat

Note=WD 9

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

593_624

1317

1750.0

Repeat

Note=TPR 1

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

64_103

1317

1750.0

Repeat

Note=WD 2

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

692_725

1317

1750.0

Repeat

Note=TPR 2

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

809_842

1317

1750.0

Repeat

Note=TPR 3

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

854_887

1317

1750.0

Repeat

Note=TPR 4

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

912_945

1317

1750.0

Repeat

Note=TPR 5

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

947_970

1317

1750.0

Repeat

Note=TPR 6

Tgene

IFT172

chr16:58550832

chr2:27672963

ENST00000260570

971_1004

1317

1750.0

Repeat

Note=TPR 7

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Fusion Gene Sequence for SETD6-IFT172

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>80924_80924_1_SETD6-IFT172_SETD6_chr16_58550832_ENST00000219315_IFT172_chr2_27672963_ENST00000260570_length(transcript)=2202nt_BP=842nt
GGAAGTGACCGCGCGGTGCGCCGGCCCGCGAGGAAACGCGCTCTTAGACCATGGCGACCCAGGCGAAGCGTCCACGGGTGGCGGGGCCCG
TGGACGGCGGCGACCTGGATCCTGTGGCCTGCTTCCTGAGCTGGTGCCGGCGGGTGGGGCTGGAGCTGAGTCCCAAGGTGAGCGAGCGAG
CCGGCGGGCGGAGGACCCGCGGCGGGGCGCGGGCTGCCCTGACCAGCCCTCCTGCTCAGGTGGCGGTCAGCCGGCAGGGCACGGTGGCCG
GCTACGGCATGGTGGCCCGGGAGAGCGTGCAGGCCGGAGAGCTGTTGTTCGTGGTGCCGCGGGCCGCGCTCCTGTCGCAGCACACCTGCT
CCATCGGCGGCCTGCTGGAGCGAGAGCGAGTTGCGCTGCAGAGCCAGTCGGGCTGGGTGCCACTGCTGCTGGCGCTGCTCCACGAGCTGC
AGGCCCCGGCCTCACGCTGGAGGCCCTACTTTGCGCTCTGGCCCGAGCTGGGCCGCTTGGAGCACCCGATGTTCTGGCCAGAGGAGGAGC
GCCGGTGCCTGCTCCAGGGCACAGGCGTACCTGAGGCCGTGGAGAAGGATTTGGCCAACATCCGCAGCGAGTACCAGTCCATCGTGCTGC
CCTTCATGGAAGCCCACCCCGATCTCTTCAGCCTCAGGGTTCGCTCCCTAGAACTCTACCACCAGCTGGTGGCCCTTGTGATGGCCTATA
GCTTTCAGGAACCACTGGAGGAAGAAGAGGATGAAAAGGAGCCCAACTCCCCCGTGATGGTGCCTGCTGCAGACATACTAAACCACTTAG
CCAATCACAACGCCAATCTAGAATACTCTGCGGCAGCTGAACTCTCCATCAAGTTTCTGCCTCCCCAACGTAATATGGAAGTCGTTCTGG
CTGTAGGACCCCAGCTGATTGGAATTGGAAAGCACAGTGCAGCTGCAGAGCTCTATCTGAATCTGGACCTTGTCAAGGAAGCAATCGATG
CTTTCATCGAGGGTGAGGAGTGGAACAAGGCGAAGCGTGTAGCTAAGGAGTTAGATCCCAGGTATGAAGACTATGTGGACCAGCATTATA
AAGAGTTCCTCAAGAATCAGGGCAAAGTGGACTCGCTGGTGGGTGTGGATGTGATAGCTGCTTTGGACCTGTATGTGGAGCAGGGCCAGT
GGGACAAGTGCATTGAAACAGCTACCAAGCAGAACTACAAGATTCTGCACAAGTATGTGGCTTTGTATGCAACTCACTTGATCCGGGAGG
GTAGCTCTGCCCAGGCATTGGCCCTGTATGTACAGCACGGAGCCCCTGCTAACCCACAGAACTTCAATATCTACAAAAGGATCTTCACTG
ACATGGTGAGCTCTCCTGGAACCAACTGTGCCGAGGCCTATCATAGCTGGGCTGATCTTCGAGATGTCCTCTTCAACCTGTGTGAAAACC
TGGTGAAGTCCAGTGAGGCAAACTCTCCAGCCCATGAGGAGTTCAAGACGATGCTGCTGATCGCTCATTACTATGCCACGCGCTCTGCAG
CCCAGAGTGTCAAACAGCTGGAAACCGTGGCTGCCAGGCTTTCTGTTTCACTCTTGCGTCACACCCAGCTACTACCTGTAGACAAAGCCT
TCTATGAAGCAGGCATTGCTGCCAAGGCAGTTGGCTGGGATAACATGGCATTCATCTTCCTCAATCGCTTTTTGGACCTGACCGATGCAA
TCGAGGAAGGGACTCTAGATGGCCTTGACCACTCTGATTTTCAGGATACAGACATTCCCTTTGAGGTGCCACTCCCAGCTAAGCAGCATG
TACCGGAGGCTGAGAGAGAAGAGGTTCGAGACTGGGTGCTTACAGTCTCCATGGACCAGCGGCTGGAGCAGGTTCTGCCTCGGGATGAGC
GTGGCGCCTACGAGGCCTCCCTAGTGGCAGCGAGCACTGGTGTTCGAGCCCTGCCCTGCCTTATTACAGGATACCCCATTCTGAGGAACA
AAATTGAATTTAAGCGGCCAGGGAAGGCTGCTAACAAGGACAACTGGAATAAATTCCTTATGGCCATCAAGACCTCCCACAGCCCAGTGT
GCCAGGACGTGCTGAAATTCATCAGTCAGTGGTGTGGAGGGCTCCCCAGCACCAGCTTTTCCTTTCAGTAGTTGGTAGAGCTGAGGAAGA

>80924_80924_1_SETD6-IFT172_SETD6_chr16_58550832_ENST00000219315_IFT172_chr2_27672963_ENST00000260570_length(amino acids)=696AA_BP=264
MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVSERAGGRRTRGGARAALTSPPAQVAVSRQGTVAGYGMVARESVQAGELLF
VVPRAALLSQHTCSIGGLLERERVALQSQSGWVPLLLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKD
LANIRSEYQSIVLPFMEAHPDLFSLRVRSLELYHQLVALVMAYSFQEPLEEEEDEKEPNSPVMVPAADILNHLANHNANLEYSAAAELSI
KFLPPQRNMEVVLAVGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRVAKELDPRYEDYVDQHYKEFLKNQGKVDSLVGVD
VIAALDLYVEQGQWDKCIETATKQNYKILHKYVALYATHLIREGSSAQALALYVQHGAPANPQNFNIYKRIFTDMVSSPGTNCAEAYHSW
ADLRDVLFNLCENLVKSSEANSPAHEEFKTMLLIAHYYATRSAAQSVKQLETVAARLSVSLLRHTQLLPVDKAFYEAGIAAKAVGWDNMA
FIFLNRFLDLTDAIEEGTLDGLDHSDFQDTDIPFEVPLPAKQHVPEAEREEVRDWVLTVSMDQRLEQVLPRDERGAYEASLVAASTGVRA

--------------------------------------------------------------
>80924_80924_2_SETD6-IFT172_SETD6_chr16_58550832_ENST00000310682_IFT172_chr2_27672963_ENST00000260570_length(transcript)=2139nt_BP=779nt
AGAGACGCCGGAAGTGACCGCGCGGTGCGCCGGCCCGCGAGGAAACGCGCTCTTAGACCATGGCGACCCAGGCGAAGCGTCCACGGGTGG
CGGGGCCCGTGGACGGCGGCGACCTGGATCCTGTGGCCTGCTTCCTGAGCTGGTGCCGGCGGGTGGGGCTGGAGCTGAGTCCCAAGGTGG
CGGTCAGCCGGCAGGGCACGGTGGCCGGCTACGGCATGGTGGCCCGGGAGAGCGTGCAGGCCGGAGAGCTGTTGTTCGTGGTGCCGCGGG
CCGCGCTCCTGTCGCAGCACACCTGCTCCATCGGCGGCCTGCTGGAGCGAGAGCGAGTTGCGCTGCAGAGCCAGTCGGGCTGGGTGCCAC
TGCTGCTGGCGCTGCTCCACGAGCTGCAGGCCCCGGCCTCACGCTGGAGGCCCTACTTTGCGCTCTGGCCCGAGCTGGGCCGCTTGGAGC
ACCCGATGTTCTGGCCAGAGGAGGAGCGCCGGTGCCTGCTCCAGGGCACAGGCGTACCTGAGGCCGTGGAGAAGGATTTGGCCAACATCC
GCAGCGAGTACCAGTCCATCGTGCTGCCCTTCATGGAAGCCCACCCCGATCTCTTCAGCCTCAGGGTTCGCTCCCTAGAACTCTACCACC
AGCTGGTGGCCCTTGTGATGGCCTATAGCTTTCAGGAACCACTGGAGGAAGAAGAGGATGAAAAGGAGCCCAACTCCCCCGTGATGGTGC
CTGCTGCAGACATACTAAACCACTTAGCCAATCACAACGCCAATCTAGAATACTCTGCGGCAGCTGAACTCTCCATCAAGTTTCTGCCTC
CCCAACGTAATATGGAAGTCGTTCTGGCTGTAGGACCCCAGCTGATTGGAATTGGAAAGCACAGTGCAGCTGCAGAGCTCTATCTGAATC
TGGACCTTGTCAAGGAAGCAATCGATGCTTTCATCGAGGGTGAGGAGTGGAACAAGGCGAAGCGTGTAGCTAAGGAGTTAGATCCCAGGT
ATGAAGACTATGTGGACCAGCATTATAAAGAGTTCCTCAAGAATCAGGGCAAAGTGGACTCGCTGGTGGGTGTGGATGTGATAGCTGCTT
TGGACCTGTATGTGGAGCAGGGCCAGTGGGACAAGTGCATTGAAACAGCTACCAAGCAGAACTACAAGATTCTGCACAAGTATGTGGCTT
TGTATGCAACTCACTTGATCCGGGAGGGTAGCTCTGCCCAGGCATTGGCCCTGTATGTACAGCACGGAGCCCCTGCTAACCCACAGAACT
TCAATATCTACAAAAGGATCTTCACTGACATGGTGAGCTCTCCTGGAACCAACTGTGCCGAGGCCTATCATAGCTGGGCTGATCTTCGAG
ATGTCCTCTTCAACCTGTGTGAAAACCTGGTGAAGTCCAGTGAGGCAAACTCTCCAGCCCATGAGGAGTTCAAGACGATGCTGCTGATCG
CTCATTACTATGCCACGCGCTCTGCAGCCCAGAGTGTCAAACAGCTGGAAACCGTGGCTGCCAGGCTTTCTGTTTCACTCTTGCGTCACA
CCCAGCTACTACCTGTAGACAAAGCCTTCTATGAAGCAGGCATTGCTGCCAAGGCAGTTGGCTGGGATAACATGGCATTCATCTTCCTCA
ATCGCTTTTTGGACCTGACCGATGCAATCGAGGAAGGGACTCTAGATGGCCTTGACCACTCTGATTTTCAGGATACAGACATTCCCTTTG
AGGTGCCACTCCCAGCTAAGCAGCATGTACCGGAGGCTGAGAGAGAAGAGGTTCGAGACTGGGTGCTTACAGTCTCCATGGACCAGCGGC
TGGAGCAGGTTCTGCCTCGGGATGAGCGTGGCGCCTACGAGGCCTCCCTAGTGGCAGCGAGCACTGGTGTTCGAGCCCTGCCCTGCCTTA
TTACAGGATACCCCATTCTGAGGAACAAAATTGAATTTAAGCGGCCAGGGAAGGCTGCTAACAAGGACAACTGGAATAAATTCCTTATGG
CCATCAAGACCTCCCACAGCCCAGTGTGCCAGGACGTGCTGAAATTCATCAGTCAGTGGTGTGGAGGGCTCCCCAGCACCAGCTTTTCCT

>80924_80924_2_SETD6-IFT172_SETD6_chr16_58550832_ENST00000310682_IFT172_chr2_27672963_ENST00000260570_length(amino acids)=672AA_BP=240
MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVAVSRQGTVAGYGMVARESVQAGELLFVVPRAALLSQHTCSIGGLLERERV
ALQSQSGWVPLLLALLHELQAPASRWRPYFALWPELGRLEHPMFWPEEERRCLLQGTGVPEAVEKDLANIRSEYQSIVLPFMEAHPDLFS
LRVRSLELYHQLVALVMAYSFQEPLEEEEDEKEPNSPVMVPAADILNHLANHNANLEYSAAAELSIKFLPPQRNMEVVLAVGPQLIGIGK
HSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRVAKELDPRYEDYVDQHYKEFLKNQGKVDSLVGVDVIAALDLYVEQGQWDKCIETATKQ
NYKILHKYVALYATHLIREGSSAQALALYVQHGAPANPQNFNIYKRIFTDMVSSPGTNCAEAYHSWADLRDVLFNLCENLVKSSEANSPA
HEEFKTMLLIAHYYATRSAAQSVKQLETVAARLSVSLLRHTQLLPVDKAFYEAGIAAKAVGWDNMAFIFLNRFLDLTDAIEEGTLDGLDH
SDFQDTDIPFEVPLPAKQHVPEAEREEVRDWVLTVSMDQRLEQVLPRDERGAYEASLVAASTGVRALPCLITGYPILRNKIEFKRPGKAA

--------------------------------------------------------------
>80924_80924_3_SETD6-IFT172_SETD6_chr16_58550832_ENST00000394266_IFT172_chr2_27672963_ENST00000260570_length(transcript)=2001nt_BP=641nt
GACGCCGGAAGTGACCGCGCGGTGCGCCGGCCCGCGAGGAAACGCGCTCTTAGACCATGGCGACCCAGGCGAAGCGTCCACGGGTGGCGG
GGCCCGTGGACGGCGGCGACCTGGATCCTGTGGCCTGCTTCCTGAGCTGGTGCCGGCGGGTGGGGCTGGAGCTGAGTCCCAAGGTGGCGG
TCAGCCGGCAGGGCACGGTGGCCGGCTACGGCATGGTGGCCCGGGAGAGCGTGCAGGCCGGAGAGCTGTTGTTCGTGGTGCCGCGGGCCG
CGCTCCTGTCGCAGCACACCTGCTCCATCGGCGGCCTGCTGGAGCGAGAGCGAGTTGCGCTGCAGAGCCAGTCGGGCTGGGTGCCACTGC
TGCTGGCGCTGCTCCACGAGCTGCAGGCCCCGGCCTCACGCTGGAGGCCCTACTTTGCGCTCTGGCCCGAGCTGGGCCGCTTGGAGCACC
CGATGTTCTGCCTCAGGGTTCGCTCCCTAGAACTCTACCACCAGCTGGTGGCCCTTGTGATGGCCTATAGCTTTCAGGAACCACTGGAGG
AAGAAGAGGATGAAAAGGAGCCCAACTCCCCCGTGATGGTGCCTGCTGCAGACATACTAAACCACTTAGCCAATCACAACGCCAATCTAG
AATACTCTGCGGCAGCTGAACTCTCCATCAAGTTTCTGCCTCCCCAACGTAATATGGAAGTCGTTCTGGCTGTAGGACCCCAGCTGATTG
GAATTGGAAAGCACAGTGCAGCTGCAGAGCTCTATCTGAATCTGGACCTTGTCAAGGAAGCAATCGATGCTTTCATCGAGGGTGAGGAGT
GGAACAAGGCGAAGCGTGTAGCTAAGGAGTTAGATCCCAGGTATGAAGACTATGTGGACCAGCATTATAAAGAGTTCCTCAAGAATCAGG
GCAAAGTGGACTCGCTGGTGGGTGTGGATGTGATAGCTGCTTTGGACCTGTATGTGGAGCAGGGCCAGTGGGACAAGTGCATTGAAACAG
CTACCAAGCAGAACTACAAGATTCTGCACAAGTATGTGGCTTTGTATGCAACTCACTTGATCCGGGAGGGTAGCTCTGCCCAGGCATTGG
CCCTGTATGTACAGCACGGAGCCCCTGCTAACCCACAGAACTTCAATATCTACAAAAGGATCTTCACTGACATGGTGAGCTCTCCTGGAA
CCAACTGTGCCGAGGCCTATCATAGCTGGGCTGATCTTCGAGATGTCCTCTTCAACCTGTGTGAAAACCTGGTGAAGTCCAGTGAGGCAA
ACTCTCCAGCCCATGAGGAGTTCAAGACGATGCTGCTGATCGCTCATTACTATGCCACGCGCTCTGCAGCCCAGAGTGTCAAACAGCTGG
AAACCGTGGCTGCCAGGCTTTCTGTTTCACTCTTGCGTCACACCCAGCTACTACCTGTAGACAAAGCCTTCTATGAAGCAGGCATTGCTG
CCAAGGCAGTTGGCTGGGATAACATGGCATTCATCTTCCTCAATCGCTTTTTGGACCTGACCGATGCAATCGAGGAAGGGACTCTAGATG
GCCTTGACCACTCTGATTTTCAGGATACAGACATTCCCTTTGAGGTGCCACTCCCAGCTAAGCAGCATGTACCGGAGGCTGAGAGAGAAG
AGGTTCGAGACTGGGTGCTTACAGTCTCCATGGACCAGCGGCTGGAGCAGGTTCTGCCTCGGGATGAGCGTGGCGCCTACGAGGCCTCCC
TAGTGGCAGCGAGCACTGGTGTTCGAGCCCTGCCCTGCCTTATTACAGGATACCCCATTCTGAGGAACAAAATTGAATTTAAGCGGCCAG
GGAAGGCTGCTAACAAGGACAACTGGAATAAATTCCTTATGGCCATCAAGACCTCCCACAGCCCAGTGTGCCAGGACGTGCTGAAATTCA
TCAGTCAGTGGTGTGGAGGGCTCCCCAGCACCAGCTTTTCCTTTCAGTAGTTGGTAGAGCTGAGGAAGAGTTAGGGCCTCTCCCTCATTA

>80924_80924_3_SETD6-IFT172_SETD6_chr16_58550832_ENST00000394266_IFT172_chr2_27672963_ENST00000260570_length(amino acids)=627AA_BP=195
MATQAKRPRVAGPVDGGDLDPVACFLSWCRRVGLELSPKVAVSRQGTVAGYGMVARESVQAGELLFVVPRAALLSQHTCSIGGLLERERV
ALQSQSGWVPLLLALLHELQAPASRWRPYFALWPELGRLEHPMFCLRVRSLELYHQLVALVMAYSFQEPLEEEEDEKEPNSPVMVPAADI
LNHLANHNANLEYSAAAELSIKFLPPQRNMEVVLAVGPQLIGIGKHSAAAELYLNLDLVKEAIDAFIEGEEWNKAKRVAKELDPRYEDYV
DQHYKEFLKNQGKVDSLVGVDVIAALDLYVEQGQWDKCIETATKQNYKILHKYVALYATHLIREGSSAQALALYVQHGAPANPQNFNIYK
RIFTDMVSSPGTNCAEAYHSWADLRDVLFNLCENLVKSSEANSPAHEEFKTMLLIAHYYATRSAAQSVKQLETVAARLSVSLLRHTQLLP
VDKAFYEAGIAAKAVGWDNMAFIFLNRFLDLTDAIEEGTLDGLDHSDFQDTDIPFEVPLPAKQHVPEAEREEVRDWVLTVSMDQRLEQVL

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Fusion Gene PPI Analysis for SETD6-IFT172

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SETD6-IFT172

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SETD6-IFT172

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source