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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SF1-TC2N (FusionGDB2 ID:81021)

Fusion Gene Summary for SF1-TC2N

check button Fusion gene summary
Fusion gene informationFusion gene name: SF1-TC2N
Fusion gene ID: 81021
HgeneTgene
Gene symbol

SF1

TC2N

Gene ID

7536

123036

Gene namesplicing factor 1tandem C2 domains, nuclear
SynonymsBBP|D11S636|MBBP|ZCCHC25|ZFM1|ZNF162C14orf47|C2CD1|MTAC2D1|Tac2-N
Cytomap

11q13.1

14q32.12

Type of geneprotein-codingprotein-coding
Descriptionsplicing factor 1mammalian branch point-binding proteintranscription factor ZFM1zinc finger gene in MEN1 locuszinc finger protein 162tandem C2 domains nuclear proteinC2 calcium-dependent domain containing 1membrane targeting (tandem) C2 domain containing 1tandem C2 protein in nucleus
Modification date2020031820200315
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000227503, ENST00000334944, 
ENST00000377387, ENST00000377390, 
ENST00000377394, ENST00000433274, 
ENST00000422298, ENST00000489544, 
ENST00000555302, ENST00000340892, 
ENST00000360594, ENST00000435962, 
ENST00000556018, 
Fusion gene scores* DoF score21 X 11 X 13=30035 X 4 X 5=100
# samples 266
** MAII scorelog2(26/3003*10)=-3.52982094652869
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SF1 [Title/Abstract] AND TC2N [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSF1(64543969)-TC2N(92249554), # samples:1
Anticipated loss of major functional domain due to fusion event.SF1-TC2N seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TC2N (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-1507SF1chr11

64543969

-TC2Nchr14

92249554

-


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Fusion Gene ORF analysis for SF1-TC2N

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000227503ENST00000555302SF1chr11

64543969

-TC2Nchr14

92249554

-
5CDS-intronENST00000334944ENST00000555302SF1chr11

64543969

-TC2Nchr14

92249554

-
5CDS-intronENST00000377387ENST00000555302SF1chr11

64543969

-TC2Nchr14

92249554

-
5CDS-intronENST00000377390ENST00000555302SF1chr11

64543969

-TC2Nchr14

92249554

-
5CDS-intronENST00000377394ENST00000555302SF1chr11

64543969

-TC2Nchr14

92249554

-
5CDS-intronENST00000433274ENST00000555302SF1chr11

64543969

-TC2Nchr14

92249554

-
5UTR-3CDSENST00000422298ENST00000340892SF1chr11

64543969

-TC2Nchr14

92249554

-
5UTR-3CDSENST00000422298ENST00000360594SF1chr11

64543969

-TC2Nchr14

92249554

-
5UTR-3CDSENST00000422298ENST00000435962SF1chr11

64543969

-TC2Nchr14

92249554

-
5UTR-3CDSENST00000422298ENST00000556018SF1chr11

64543969

-TC2Nchr14

92249554

-
5UTR-intronENST00000422298ENST00000555302SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000227503ENST00000340892SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000227503ENST00000435962SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000227503ENST00000556018SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000334944ENST00000340892SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000334944ENST00000435962SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000334944ENST00000556018SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000377387ENST00000340892SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000377387ENST00000435962SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000377387ENST00000556018SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000377390ENST00000340892SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000377390ENST00000435962SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000377390ENST00000556018SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000377394ENST00000340892SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000377394ENST00000435962SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000377394ENST00000556018SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000433274ENST00000360594SF1chr11

64543969

-TC2Nchr14

92249554

-
Frame-shiftENST00000433274ENST00000556018SF1chr11

64543969

-TC2Nchr14

92249554

-
In-frameENST00000227503ENST00000360594SF1chr11

64543969

-TC2Nchr14

92249554

-
In-frameENST00000334944ENST00000360594SF1chr11

64543969

-TC2Nchr14

92249554

-
In-frameENST00000377387ENST00000360594SF1chr11

64543969

-TC2Nchr14

92249554

-
In-frameENST00000377390ENST00000360594SF1chr11

64543969

-TC2Nchr14

92249554

-
In-frameENST00000377394ENST00000360594SF1chr11

64543969

-TC2Nchr14

92249554

-
In-frameENST00000433274ENST00000340892SF1chr11

64543969

-TC2Nchr14

92249554

-
In-frameENST00000433274ENST00000435962SF1chr11

64543969

-TC2Nchr14

92249554

-
intron-3CDSENST00000489544ENST00000340892SF1chr11

64543969

-TC2Nchr14

92249554

-
intron-3CDSENST00000489544ENST00000360594SF1chr11

64543969

-TC2Nchr14

92249554

-
intron-3CDSENST00000489544ENST00000435962SF1chr11

64543969

-TC2Nchr14

92249554

-
intron-3CDSENST00000489544ENST00000556018SF1chr11

64543969

-TC2Nchr14

92249554

-
intron-intronENST00000489544ENST00000555302SF1chr11

64543969

-TC2Nchr14

92249554

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000377387SF1chr1164543969-ENST00000360594TC2Nchr1492249554-28686127062235
ENST00000377390SF1chr1164543969-ENST00000360594TC2Nchr1492249554-275449859259177
ENST00000377394SF1chr1164543969-ENST00000360594TC2Nchr1492249554-277151560976177
ENST00000227503SF1chr1164543969-ENST00000360594TC2Nchr1492249554-277151560976177
ENST00000334944SF1chr1164543969-ENST00000360594TC2Nchr1492249554-2810554648115177
ENST00000433274SF1chr1164543969-ENST00000435962TC2Nchr1492249554-385139148524978
ENST00000433274SF1chr1164543969-ENST00000340892TC2Nchr1492249554-342339148524978

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377387ENST00000360594SF1chr1164543969-TC2Nchr1492249554-0.0087419580.99125797
ENST00000377390ENST00000360594SF1chr1164543969-TC2Nchr1492249554-0.790025060.20997494
ENST00000377394ENST00000360594SF1chr1164543969-TC2Nchr1492249554-0.940634250.05936579
ENST00000227503ENST00000360594SF1chr1164543969-TC2Nchr1492249554-0.940634250.05936579
ENST00000334944ENST00000360594SF1chr1164543969-TC2Nchr1492249554-0.930026770.06997321
ENST00000433274ENST00000435962SF1chr1164543969-TC2Nchr1492249554-0.93425870.06574133
ENST00000433274ENST00000340892SF1chr1164543969-TC2Nchr1492249554-0.836349960.16365005

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Fusion Genomic Features for SF1-TC2N


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SF1-TC2N


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:64543969/chr14:92249554)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSF1chr11:64543969chr14:92249554ENST00000227503-21315_1953549.0MotifNuclear localization signal
HgeneSF1chr11:64543969chr14:92249554ENST00000334944-21415_1953639.0MotifNuclear localization signal
HgeneSF1chr11:64543969chr14:92249554ENST00000377387-21315_19178674.0MotifNuclear localization signal
HgeneSF1chr11:64543969chr14:92249554ENST00000377390-21315_1953640.0MotifNuclear localization signal
HgeneSF1chr11:64543969chr14:92249554ENST00000377394-21315_1953572.0MotifNuclear localization signal
HgeneSF1chr11:64543969chr14:92249554ENST00000433274-21315_1927614.0MotifNuclear localization signal
TgeneTC2Nchr11:64543969chr14:92249554ENST00000556018911447_449390427.0MotifNuclear localization signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSF1chr11:64543969chr14:92249554ENST00000227503-213324_63753549.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543969chr14:92249554ENST00000334944-214324_63753639.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543969chr14:92249554ENST00000377387-213324_637178674.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543969chr14:92249554ENST00000377390-213324_63753640.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543969chr14:92249554ENST00000377394-213324_63753572.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543969chr14:92249554ENST00000433274-213324_63727614.0Compositional biasNote=Pro-rich
HgeneSF1chr11:64543969chr14:92249554ENST00000227503-213141_22253549.0DomainKH
HgeneSF1chr11:64543969chr14:92249554ENST00000334944-214141_22253639.0DomainKH
HgeneSF1chr11:64543969chr14:92249554ENST00000377387-213141_222178674.0DomainKH
HgeneSF1chr11:64543969chr14:92249554ENST00000377390-213141_22253640.0DomainKH
HgeneSF1chr11:64543969chr14:92249554ENST00000377394-213141_22253572.0DomainKH
HgeneSF1chr11:64543969chr14:92249554ENST00000433274-213141_22227614.0DomainKH
HgeneSF1chr11:64543969chr14:92249554ENST00000227503-213277_29653549.0Zinc fingerCCHC-type
HgeneSF1chr11:64543969chr14:92249554ENST00000334944-214277_29653639.0Zinc fingerCCHC-type
HgeneSF1chr11:64543969chr14:92249554ENST00000377387-213277_296178674.0Zinc fingerCCHC-type
HgeneSF1chr11:64543969chr14:92249554ENST00000377390-213277_29653640.0Zinc fingerCCHC-type
HgeneSF1chr11:64543969chr14:92249554ENST00000377394-213277_29653572.0Zinc fingerCCHC-type
HgeneSF1chr11:64543969chr14:92249554ENST00000433274-213277_29627614.0Zinc fingerCCHC-type
TgeneTC2Nchr11:64543969chr14:92249554ENST000003408921012223_342454491.0DomainC2 1
TgeneTC2Nchr11:64543969chr14:92249554ENST000003408921012344_471454491.0DomainC2 2
TgeneTC2Nchr11:64543969chr14:92249554ENST000003605941012223_342454491.0DomainC2 1
TgeneTC2Nchr11:64543969chr14:92249554ENST000003605941012344_471454491.0DomainC2 2
TgeneTC2Nchr11:64543969chr14:92249554ENST000004359621012223_342454491.0DomainC2 1
TgeneTC2Nchr11:64543969chr14:92249554ENST000004359621012344_471454491.0DomainC2 2
TgeneTC2Nchr11:64543969chr14:92249554ENST00000556018911223_342390427.0DomainC2 1
TgeneTC2Nchr11:64543969chr14:92249554ENST00000556018911344_471390427.0DomainC2 2
TgeneTC2Nchr11:64543969chr14:92249554ENST000003408921012447_449454491.0MotifNuclear localization signal
TgeneTC2Nchr11:64543969chr14:92249554ENST000003605941012447_449454491.0MotifNuclear localization signal
TgeneTC2Nchr11:64543969chr14:92249554ENST000004359621012447_449454491.0MotifNuclear localization signal


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Fusion Gene Sequence for SF1-TC2N


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81021_81021_1_SF1-TC2N_SF1_chr11_64543969_ENST00000227503_TC2N_chr14_92249554_ENST00000360594_length(transcript)=2771nt_BP=515nt
GCGACACCTCCCAGCCCACCGAACTCCGCCGCCATTTCCTCGCTTGGCCTAACGGTTCGGCCAATCCCAGCGCGCATCAAGAAGGACTGA
GGCTCCGCCAATCGGAGGCCGCCGATTTCGACCCTTCGCCTCGGCCCGGCCCAATCCAGGCCCCGGCCCCGCCGCCCCCGGCCCGCCCCC
GCGGTGCCCTCTCTCCTCCCTCTTTGTGCGTCTCGCGCCGCCGCCGCCCGCCGCGTGAGAGGACGGGCTCCGCGCGCTCCGGCAGCGCAT
TCGGGTCCCCTCCCCCCGGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGAAAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGC
GACCGGAGCGAACGCCACGCCGTTGGACTTCCCAAGTAAGAAGCGGAAGAGGAGCCGCTGGAACCAAGACACAATGGAACAGAAGACAGT
GATTCCAGGAATGCCTACAGTTATTCCCCCTGGACTTACTCGAGAACAAGAAAGAGCTTATATAGATTTGGATAAGTGAAGACAGTAATA
ACATTGAAGCAGTGAACCAGTGGAAAGAGACAGTAATAAATCCAGAAAAGGTTGTTATCAGGTGGCACAAATTAAATCCATCTTGAAGAC
TTCACACATTAATTTGGTGAAGAACTTGACATTCTTTTAGAAGACTTATGATTTCAATTTGCTACCAATGAGAAGAGGCAAATCAACAAA
TTTGTCAATTTATGGGGGCTATAATTATGGTATATAATGTATCTGATAGAAAATTTGATAAGAAAATGTAATGAATTTTATCAGATATCC
AAAGTAAAGGAAATGTTTTAAAACTGCAACAAGAGACACAGACAGTAAAATCAAAGTATTATTAGGATGACTAAATAAATTATAAAGTCT
GTGAGAATATCAACCATAGATAGTTCTTTCTATATTATGTTTTCGCTTTTGTATTTTAAGCTTTACTTAGATATTCAAAACCTGGTATAT
CAAGTCTCTGTTAGTACTATTGGCATTTAGAAGACTTTACCATTATTTCAGTGCTAGGCATTATTGATTAGGTCTTGGCTCCACTGTTTA
CCTCTTGCTATGTATTTTCTCCCGGTAAAAATGAATTGAACCATTTCAACTATTTTCTATATTTGGAGAAAGTTTGTGCCCTGTGTTTTA
TAATTTTTTTACCCATAAGACATCACATTATCCCTTTGTAAGCTACTTATCTCCAAAAAACTTCAGAAATAGAAAACTACATTTTGGCAG
GAATAATTGAAAACACCAGAAGGTTGAAGTTTAATTGGAAACCCAGAATATACATACTTTGCTGTTTTCTTCCCTCAAATATTTTACTAT
TTGTTTTATTTGGAGTTAAAATAAGAGTATCATCCATATGGTCCATCCTAATTCACAGAATTAAATGAGCTTAAATAGAAAATTCAGTAT
TTTATGATAATCACTTCGTTTTTAGTTTTTAAAATTTAGATTATTCTATAATTTACCGTGTTTGAGTATTTTCTCATTTTTTTCATAACC
ATACCTGATTATACTGTGTAACAAATATTTTCTATTGCAGTTTTCTTTCCAGTACTTATTAGAACTCAGTATTTGGAAATAATTTCAGCT
TAATTGACCATAAGAACTGTGGCCAAAAAGAACAGTTTTTTGGAGAGGCAGATGACATTATACCTGATTTTAGAAAATCTCACTTTATTT
TTGCTAATAAGTAGACTAAGTGCTCTGTGTTCTCAGTCTTCCCTTTTTTTCTGCCCCCATTCTTACTTTGTCCCAGGCATGCAGAGAAAG
ATGGTGATATTTTAGGCCAGGAGTATACCTTGCTATAACCTAAGCATGCCTTCTTTATTCCAGCTCCTATGTTCTGTGTATATCATTAAC
ATTTTCCCAAATAAACACTTAATTCTCTTTTCCCTAGGTGCCATCTCCTCAAGCTACAAAATGTCCACATCTTATATCCCCTTTGCTTCT
ACTGCTCTGATTTTGTGGTACCAGTACTCTCTGCCACTGAACATTTTGAAATATTTTTGTTTTAGATTTGCAAAAAATGACATATAGGTC
AGTACTCACATGGATTTTTAAGATAAATCACCTGTGTGATAATATTTTGAATCTGAGACGAATACAACTTTTAAAAATTGTTTTTAAAAA
TAGACTTTTTTTTTTAGAGCAGTTGTAGGTTAACAGAAAAATTGAGAGGAAGATAGAGATTTCCTTTCTCCCCTGACAAAGCCCTCAACA
GCCTCCCAGGCTATCAGTATCCTGCACCACAATGGTACATTTGTTACAATCAATGAACCTACTCTGAAACATCATTATCATCCAAAGTTC
ATGGTTTACATTAGAGTCCCCTCTTGGTGTTATACATGCTAGAGGACAAATATATGATGATATGTATGCATCATTATAATATAGTATAGT
TTCGCTGCCCTAAACATCCTCTGCAAATGCAACTATTTTAATGGGTACCAAAGAAGTAAATGTATTTACTGGCTTTTAGATAATAAATAA
CGGGCTTTATTGTTTATTTTAAAAGCTACAATTTGTTTTAGCTGGTTTCTCTGTTCTATTAATGCTTTGAATTTCCAAATTTAATATATG
TAGTCATGCATTTAACTTAATATTTAATTATTTGATTTATTTAATTTTCTATATTCTTACAATGTATGTATGATGTATAATTTAAGGGAA

>81021_81021_1_SF1-TC2N_SF1_chr11_64543969_ENST00000227503_TC2N_chr14_92249554_ENST00000360594_length(amino acids)=177AA_BP=1
MCHLITTFSGFITVSFHWFTASMLLLSSLIQIYISSFLFSSKSRGNNCRHSWNHCLLFHCVLVPAAPLPLLTWEVQRRGVRSGRHGAPGD

--------------------------------------------------------------
>81021_81021_2_SF1-TC2N_SF1_chr11_64543969_ENST00000334944_TC2N_chr14_92249554_ENST00000360594_length(transcript)=2810nt_BP=554nt
CGGAGCTCAGTTCACGCAGTAACAAATGAAGTGCGCGCTGCGACACCTCCCAGCCCACCGAACTCCGCCGCCATTTCCTCGCTTGGCCTA
ACGGTTCGGCCAATCCCAGCGCGCATCAAGAAGGACTGAGGCTCCGCCAATCGGAGGCCGCCGATTTCGACCCTTCGCCTCGGCCCGGCC
CAATCCAGGCCCCGGCCCCGCCGCCCCCGGCCCGCCCCCGCGGTGCCCTCTCTCCTCCCTCTTTGTGCGTCTCGCGCCGCCGCCGCCCGC
CGCGTGAGAGGACGGGCTCCGCGCGCTCCGGCAGCGCATTCGGGTCCCCTCCCCCCGGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGA
AAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGCGACCGGAGCGAACGCCACGCCGTTGGACTTCCCAAGTAAGAAGCGGAAGAG
GAGCCGCTGGAACCAAGACACAATGGAACAGAAGACAGTGATTCCAGGAATGCCTACAGTTATTCCCCCTGGACTTACTCGAGAACAAGA
AAGAGCTTATATAGATTTGGATAAGTGAAGACAGTAATAACATTGAAGCAGTGAACCAGTGGAAAGAGACAGTAATAAATCCAGAAAAGG
TTGTTATCAGGTGGCACAAATTAAATCCATCTTGAAGACTTCACACATTAATTTGGTGAAGAACTTGACATTCTTTTAGAAGACTTATGA
TTTCAATTTGCTACCAATGAGAAGAGGCAAATCAACAAATTTGTCAATTTATGGGGGCTATAATTATGGTATATAATGTATCTGATAGAA
AATTTGATAAGAAAATGTAATGAATTTTATCAGATATCCAAAGTAAAGGAAATGTTTTAAAACTGCAACAAGAGACACAGACAGTAAAAT
CAAAGTATTATTAGGATGACTAAATAAATTATAAAGTCTGTGAGAATATCAACCATAGATAGTTCTTTCTATATTATGTTTTCGCTTTTG
TATTTTAAGCTTTACTTAGATATTCAAAACCTGGTATATCAAGTCTCTGTTAGTACTATTGGCATTTAGAAGACTTTACCATTATTTCAG
TGCTAGGCATTATTGATTAGGTCTTGGCTCCACTGTTTACCTCTTGCTATGTATTTTCTCCCGGTAAAAATGAATTGAACCATTTCAACT
ATTTTCTATATTTGGAGAAAGTTTGTGCCCTGTGTTTTATAATTTTTTTACCCATAAGACATCACATTATCCCTTTGTAAGCTACTTATC
TCCAAAAAACTTCAGAAATAGAAAACTACATTTTGGCAGGAATAATTGAAAACACCAGAAGGTTGAAGTTTAATTGGAAACCCAGAATAT
ACATACTTTGCTGTTTTCTTCCCTCAAATATTTTACTATTTGTTTTATTTGGAGTTAAAATAAGAGTATCATCCATATGGTCCATCCTAA
TTCACAGAATTAAATGAGCTTAAATAGAAAATTCAGTATTTTATGATAATCACTTCGTTTTTAGTTTTTAAAATTTAGATTATTCTATAA
TTTACCGTGTTTGAGTATTTTCTCATTTTTTTCATAACCATACCTGATTATACTGTGTAACAAATATTTTCTATTGCAGTTTTCTTTCCA
GTACTTATTAGAACTCAGTATTTGGAAATAATTTCAGCTTAATTGACCATAAGAACTGTGGCCAAAAAGAACAGTTTTTTGGAGAGGCAG
ATGACATTATACCTGATTTTAGAAAATCTCACTTTATTTTTGCTAATAAGTAGACTAAGTGCTCTGTGTTCTCAGTCTTCCCTTTTTTTC
TGCCCCCATTCTTACTTTGTCCCAGGCATGCAGAGAAAGATGGTGATATTTTAGGCCAGGAGTATACCTTGCTATAACCTAAGCATGCCT
TCTTTATTCCAGCTCCTATGTTCTGTGTATATCATTAACATTTTCCCAAATAAACACTTAATTCTCTTTTCCCTAGGTGCCATCTCCTCA
AGCTACAAAATGTCCACATCTTATATCCCCTTTGCTTCTACTGCTCTGATTTTGTGGTACCAGTACTCTCTGCCACTGAACATTTTGAAA
TATTTTTGTTTTAGATTTGCAAAAAATGACATATAGGTCAGTACTCACATGGATTTTTAAGATAAATCACCTGTGTGATAATATTTTGAA
TCTGAGACGAATACAACTTTTAAAAATTGTTTTTAAAAATAGACTTTTTTTTTTAGAGCAGTTGTAGGTTAACAGAAAAATTGAGAGGAA
GATAGAGATTTCCTTTCTCCCCTGACAAAGCCCTCAACAGCCTCCCAGGCTATCAGTATCCTGCACCACAATGGTACATTTGTTACAATC
AATGAACCTACTCTGAAACATCATTATCATCCAAAGTTCATGGTTTACATTAGAGTCCCCTCTTGGTGTTATACATGCTAGAGGACAAAT
ATATGATGATATGTATGCATCATTATAATATAGTATAGTTTCGCTGCCCTAAACATCCTCTGCAAATGCAACTATTTTAATGGGTACCAA
AGAAGTAAATGTATTTACTGGCTTTTAGATAATAAATAACGGGCTTTATTGTTTATTTTAAAAGCTACAATTTGTTTTAGCTGGTTTCTC
TGTTCTATTAATGCTTTGAATTTCCAAATTTAATATATGTAGTCATGCATTTAACTTAATATTTAATTATTTGATTTATTTAATTTTCTA
TATTCTTACAATGTATGTATGATGTATAATTTAAGGGAAAGCTATGACTTCTCAGTTTCTTAGAATCCTAGGTAAATAAAACAATAAAAA

>81021_81021_2_SF1-TC2N_SF1_chr11_64543969_ENST00000334944_TC2N_chr14_92249554_ENST00000360594_length(amino acids)=177AA_BP=1
MCHLITTFSGFITVSFHWFTASMLLLSSLIQIYISSFLFSSKSRGNNCRHSWNHCLLFHCVLVPAAPLPLLTWEVQRRGVRSGRHGAPGD

--------------------------------------------------------------
>81021_81021_3_SF1-TC2N_SF1_chr11_64543969_ENST00000377387_TC2N_chr14_92249554_ENST00000360594_length(transcript)=2868nt_BP=612nt
CCTCCCCCCGGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGAAAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGCGACCGGAG
CGAACGCCACGCCGTTGGGTAAGCTGGGCCCCCCCGGGCTGCCCCCGCTCCCCGGGCCCAAAGGAGGCTTCGAGCCGGGCCCTCCGCCTG
CACCCGGGCCTGGGGCGGGGCTGCTGGCTCCCGGGCCGCCGCCGCCCCCGCCCGTGGGCTCGATGGGGGCCCTGACCGCGGCCTTCCCCT
TCGCGGCGCTGCCTCCGCCGCCTCCGCCGCCGCCCCCTCCGCCTCCCCAGCAGCCGCCGCCGCCTCCACCGCCACCGTCCCCCGGCGCCT
CGTACCCGCCGCCGCAGCCGCCCCCTCCGCCGCCGCTCTACCAGCGCGTGTCGCCGCCGCAGCCGCCGCCACCCCAGCCGCCGCGTAAGG
ACCAGCAGCCGGGCCCGGCCGGCGGCGGAGGAGACTTCCCAAGTAAGAAGCGGAAGAGGAGCCGCTGGAACCAAGACACAATGGAACAGA
AGACAGTGATTCCAGGAATGCCTACAGTTATTCCCCCTGGACTTACTCGAGAACAAGAAAGAGCTTATATAGATTTGGATAAGTGAAGAC
AGTAATAACATTGAAGCAGTGAACCAGTGGAAAGAGACAGTAATAAATCCAGAAAAGGTTGTTATCAGGTGGCACAAATTAAATCCATCT
TGAAGACTTCACACATTAATTTGGTGAAGAACTTGACATTCTTTTAGAAGACTTATGATTTCAATTTGCTACCAATGAGAAGAGGCAAAT
CAACAAATTTGTCAATTTATGGGGGCTATAATTATGGTATATAATGTATCTGATAGAAAATTTGATAAGAAAATGTAATGAATTTTATCA
GATATCCAAAGTAAAGGAAATGTTTTAAAACTGCAACAAGAGACACAGACAGTAAAATCAAAGTATTATTAGGATGACTAAATAAATTAT
AAAGTCTGTGAGAATATCAACCATAGATAGTTCTTTCTATATTATGTTTTCGCTTTTGTATTTTAAGCTTTACTTAGATATTCAAAACCT
GGTATATCAAGTCTCTGTTAGTACTATTGGCATTTAGAAGACTTTACCATTATTTCAGTGCTAGGCATTATTGATTAGGTCTTGGCTCCA
CTGTTTACCTCTTGCTATGTATTTTCTCCCGGTAAAAATGAATTGAACCATTTCAACTATTTTCTATATTTGGAGAAAGTTTGTGCCCTG
TGTTTTATAATTTTTTTACCCATAAGACATCACATTATCCCTTTGTAAGCTACTTATCTCCAAAAAACTTCAGAAATAGAAAACTACATT
TTGGCAGGAATAATTGAAAACACCAGAAGGTTGAAGTTTAATTGGAAACCCAGAATATACATACTTTGCTGTTTTCTTCCCTCAAATATT
TTACTATTTGTTTTATTTGGAGTTAAAATAAGAGTATCATCCATATGGTCCATCCTAATTCACAGAATTAAATGAGCTTAAATAGAAAAT
TCAGTATTTTATGATAATCACTTCGTTTTTAGTTTTTAAAATTTAGATTATTCTATAATTTACCGTGTTTGAGTATTTTCTCATTTTTTT
CATAACCATACCTGATTATACTGTGTAACAAATATTTTCTATTGCAGTTTTCTTTCCAGTACTTATTAGAACTCAGTATTTGGAAATAAT
TTCAGCTTAATTGACCATAAGAACTGTGGCCAAAAAGAACAGTTTTTTGGAGAGGCAGATGACATTATACCTGATTTTAGAAAATCTCAC
TTTATTTTTGCTAATAAGTAGACTAAGTGCTCTGTGTTCTCAGTCTTCCCTTTTTTTCTGCCCCCATTCTTACTTTGTCCCAGGCATGCA
GAGAAAGATGGTGATATTTTAGGCCAGGAGTATACCTTGCTATAACCTAAGCATGCCTTCTTTATTCCAGCTCCTATGTTCTGTGTATAT
CATTAACATTTTCCCAAATAAACACTTAATTCTCTTTTCCCTAGGTGCCATCTCCTCAAGCTACAAAATGTCCACATCTTATATCCCCTT
TGCTTCTACTGCTCTGATTTTGTGGTACCAGTACTCTCTGCCACTGAACATTTTGAAATATTTTTGTTTTAGATTTGCAAAAAATGACAT
ATAGGTCAGTACTCACATGGATTTTTAAGATAAATCACCTGTGTGATAATATTTTGAATCTGAGACGAATACAACTTTTAAAAATTGTTT
TTAAAAATAGACTTTTTTTTTTAGAGCAGTTGTAGGTTAACAGAAAAATTGAGAGGAAGATAGAGATTTCCTTTCTCCCCTGACAAAGCC
CTCAACAGCCTCCCAGGCTATCAGTATCCTGCACCACAATGGTACATTTGTTACAATCAATGAACCTACTCTGAAACATCATTATCATCC
AAAGTTCATGGTTTACATTAGAGTCCCCTCTTGGTGTTATACATGCTAGAGGACAAATATATGATGATATGTATGCATCATTATAATATA
GTATAGTTTCGCTGCCCTAAACATCCTCTGCAAATGCAACTATTTTAATGGGTACCAAAGAAGTAAATGTATTTACTGGCTTTTAGATAA
TAAATAACGGGCTTTATTGTTTATTTTAAAAGCTACAATTTGTTTTAGCTGGTTTCTCTGTTCTATTAATGCTTTGAATTTCCAAATTTA
ATATATGTAGTCATGCATTTAACTTAATATTTAATTATTTGATTTATTTAATTTTCTATATTCTTACAATGTATGTATGATGTATAATTT

>81021_81021_3_SF1-TC2N_SF1_chr11_64543969_ENST00000377387_TC2N_chr14_92249554_ENST00000360594_length(amino acids)=235AA_BP=1
MCHLITTFSGFITVSFHWFTASMLLLSSLIQIYISSFLFSSKSRGNNCRHSWNHCLLFHCVLVPAAPLPLLTWEVSSAAGRARLLVLTRR
LGWRRLRRRHALVERRRRGRLRRRVRGAGGRWRWRRRRLLGRRRGRRRRRRRQRREGEGRGQGPHRAHGRGRRRPGSQQPRPRPGCRRRA

--------------------------------------------------------------
>81021_81021_4_SF1-TC2N_SF1_chr11_64543969_ENST00000377390_TC2N_chr14_92249554_ENST00000360594_length(transcript)=2754nt_BP=498nt
ACCGAACTCCGCCGCCATTTCCTCGCTTGGCCTAACGGTTCGGCCAATCCCAGCGCGCATCAAGAAGGACTGAGGCTCCGCCAATCGGAG
GCCGCCGATTTCGACCCTTCGCCTCGGCCCGGCCCAATCCAGGCCCCGGCCCCGCCGCCCCCGGCCCGCCCCCGCGGTGCCCTCTCTCCT
CCCTCTTTGTGCGTCTCGCGCCGCCGCCGCCCGCCGCGTGAGAGGACGGGCTCCGCGCGCTCCGGCAGCGCATTCGGGTCCCCTCCCCCC
GGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGAAAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGCGACCGGAGCGAACGCCA
CGCCGTTGGACTTCCCAAGTAAGAAGCGGAAGAGGAGCCGCTGGAACCAAGACACAATGGAACAGAAGACAGTGATTCCAGGAATGCCTA
CAGTTATTCCCCCTGGACTTACTCGAGAACAAGAAAGAGCTTATATAGATTTGGATAAGTGAAGACAGTAATAACATTGAAGCAGTGAAC
CAGTGGAAAGAGACAGTAATAAATCCAGAAAAGGTTGTTATCAGGTGGCACAAATTAAATCCATCTTGAAGACTTCACACATTAATTTGG
TGAAGAACTTGACATTCTTTTAGAAGACTTATGATTTCAATTTGCTACCAATGAGAAGAGGCAAATCAACAAATTTGTCAATTTATGGGG
GCTATAATTATGGTATATAATGTATCTGATAGAAAATTTGATAAGAAAATGTAATGAATTTTATCAGATATCCAAAGTAAAGGAAATGTT
TTAAAACTGCAACAAGAGACACAGACAGTAAAATCAAAGTATTATTAGGATGACTAAATAAATTATAAAGTCTGTGAGAATATCAACCAT
AGATAGTTCTTTCTATATTATGTTTTCGCTTTTGTATTTTAAGCTTTACTTAGATATTCAAAACCTGGTATATCAAGTCTCTGTTAGTAC
TATTGGCATTTAGAAGACTTTACCATTATTTCAGTGCTAGGCATTATTGATTAGGTCTTGGCTCCACTGTTTACCTCTTGCTATGTATTT
TCTCCCGGTAAAAATGAATTGAACCATTTCAACTATTTTCTATATTTGGAGAAAGTTTGTGCCCTGTGTTTTATAATTTTTTTACCCATA
AGACATCACATTATCCCTTTGTAAGCTACTTATCTCCAAAAAACTTCAGAAATAGAAAACTACATTTTGGCAGGAATAATTGAAAACACC
AGAAGGTTGAAGTTTAATTGGAAACCCAGAATATACATACTTTGCTGTTTTCTTCCCTCAAATATTTTACTATTTGTTTTATTTGGAGTT
AAAATAAGAGTATCATCCATATGGTCCATCCTAATTCACAGAATTAAATGAGCTTAAATAGAAAATTCAGTATTTTATGATAATCACTTC
GTTTTTAGTTTTTAAAATTTAGATTATTCTATAATTTACCGTGTTTGAGTATTTTCTCATTTTTTTCATAACCATACCTGATTATACTGT
GTAACAAATATTTTCTATTGCAGTTTTCTTTCCAGTACTTATTAGAACTCAGTATTTGGAAATAATTTCAGCTTAATTGACCATAAGAAC
TGTGGCCAAAAAGAACAGTTTTTTGGAGAGGCAGATGACATTATACCTGATTTTAGAAAATCTCACTTTATTTTTGCTAATAAGTAGACT
AAGTGCTCTGTGTTCTCAGTCTTCCCTTTTTTTCTGCCCCCATTCTTACTTTGTCCCAGGCATGCAGAGAAAGATGGTGATATTTTAGGC
CAGGAGTATACCTTGCTATAACCTAAGCATGCCTTCTTTATTCCAGCTCCTATGTTCTGTGTATATCATTAACATTTTCCCAAATAAACA
CTTAATTCTCTTTTCCCTAGGTGCCATCTCCTCAAGCTACAAAATGTCCACATCTTATATCCCCTTTGCTTCTACTGCTCTGATTTTGTG
GTACCAGTACTCTCTGCCACTGAACATTTTGAAATATTTTTGTTTTAGATTTGCAAAAAATGACATATAGGTCAGTACTCACATGGATTT
TTAAGATAAATCACCTGTGTGATAATATTTTGAATCTGAGACGAATACAACTTTTAAAAATTGTTTTTAAAAATAGACTTTTTTTTTTAG
AGCAGTTGTAGGTTAACAGAAAAATTGAGAGGAAGATAGAGATTTCCTTTCTCCCCTGACAAAGCCCTCAACAGCCTCCCAGGCTATCAG
TATCCTGCACCACAATGGTACATTTGTTACAATCAATGAACCTACTCTGAAACATCATTATCATCCAAAGTTCATGGTTTACATTAGAGT
CCCCTCTTGGTGTTATACATGCTAGAGGACAAATATATGATGATATGTATGCATCATTATAATATAGTATAGTTTCGCTGCCCTAAACAT
CCTCTGCAAATGCAACTATTTTAATGGGTACCAAAGAAGTAAATGTATTTACTGGCTTTTAGATAATAAATAACGGGCTTTATTGTTTAT
TTTAAAAGCTACAATTTGTTTTAGCTGGTTTCTCTGTTCTATTAATGCTTTGAATTTCCAAATTTAATATATGTAGTCATGCATTTAACT
TAATATTTAATTATTTGATTTATTTAATTTTCTATATTCTTACAATGTATGTATGATGTATAATTTAAGGGAAAGCTATGACTTCTCAGT

>81021_81021_4_SF1-TC2N_SF1_chr11_64543969_ENST00000377390_TC2N_chr14_92249554_ENST00000360594_length(amino acids)=177AA_BP=1
MCHLITTFSGFITVSFHWFTASMLLLSSLIQIYISSFLFSSKSRGNNCRHSWNHCLLFHCVLVPAAPLPLLTWEVQRRGVRSGRHGAPGD

--------------------------------------------------------------
>81021_81021_5_SF1-TC2N_SF1_chr11_64543969_ENST00000377394_TC2N_chr14_92249554_ENST00000360594_length(transcript)=2771nt_BP=515nt
GCGACACCTCCCAGCCCACCGAACTCCGCCGCCATTTCCTCGCTTGGCCTAACGGTTCGGCCAATCCCAGCGCGCATCAAGAAGGACTGA
GGCTCCGCCAATCGGAGGCCGCCGATTTCGACCCTTCGCCTCGGCCCGGCCCAATCCAGGCCCCGGCCCCGCCGCCCCCGGCCCGCCCCC
GCGGTGCCCTCTCTCCTCCCTCTTTGTGCGTCTCGCGCCGCCGCCGCCCGCCGCGTGAGAGGACGGGCTCCGCGCGCTCCGGCAGCGCAT
TCGGGTCCCCTCCCCCCGGGAGGCTTGCGAAGGAGAAGCCGCCGCAGAGGAAAAGCAGGTGCCGGTGCCTGTCCCCGGGGGCGCCATGGC
GACCGGAGCGAACGCCACGCCGTTGGACTTCCCAAGTAAGAAGCGGAAGAGGAGCCGCTGGAACCAAGACACAATGGAACAGAAGACAGT
GATTCCAGGAATGCCTACAGTTATTCCCCCTGGACTTACTCGAGAACAAGAAAGAGCTTATATAGATTTGGATAAGTGAAGACAGTAATA
ACATTGAAGCAGTGAACCAGTGGAAAGAGACAGTAATAAATCCAGAAAAGGTTGTTATCAGGTGGCACAAATTAAATCCATCTTGAAGAC
TTCACACATTAATTTGGTGAAGAACTTGACATTCTTTTAGAAGACTTATGATTTCAATTTGCTACCAATGAGAAGAGGCAAATCAACAAA
TTTGTCAATTTATGGGGGCTATAATTATGGTATATAATGTATCTGATAGAAAATTTGATAAGAAAATGTAATGAATTTTATCAGATATCC
AAAGTAAAGGAAATGTTTTAAAACTGCAACAAGAGACACAGACAGTAAAATCAAAGTATTATTAGGATGACTAAATAAATTATAAAGTCT
GTGAGAATATCAACCATAGATAGTTCTTTCTATATTATGTTTTCGCTTTTGTATTTTAAGCTTTACTTAGATATTCAAAACCTGGTATAT
CAAGTCTCTGTTAGTACTATTGGCATTTAGAAGACTTTACCATTATTTCAGTGCTAGGCATTATTGATTAGGTCTTGGCTCCACTGTTTA
CCTCTTGCTATGTATTTTCTCCCGGTAAAAATGAATTGAACCATTTCAACTATTTTCTATATTTGGAGAAAGTTTGTGCCCTGTGTTTTA
TAATTTTTTTACCCATAAGACATCACATTATCCCTTTGTAAGCTACTTATCTCCAAAAAACTTCAGAAATAGAAAACTACATTTTGGCAG
GAATAATTGAAAACACCAGAAGGTTGAAGTTTAATTGGAAACCCAGAATATACATACTTTGCTGTTTTCTTCCCTCAAATATTTTACTAT
TTGTTTTATTTGGAGTTAAAATAAGAGTATCATCCATATGGTCCATCCTAATTCACAGAATTAAATGAGCTTAAATAGAAAATTCAGTAT
TTTATGATAATCACTTCGTTTTTAGTTTTTAAAATTTAGATTATTCTATAATTTACCGTGTTTGAGTATTTTCTCATTTTTTTCATAACC
ATACCTGATTATACTGTGTAACAAATATTTTCTATTGCAGTTTTCTTTCCAGTACTTATTAGAACTCAGTATTTGGAAATAATTTCAGCT
TAATTGACCATAAGAACTGTGGCCAAAAAGAACAGTTTTTTGGAGAGGCAGATGACATTATACCTGATTTTAGAAAATCTCACTTTATTT
TTGCTAATAAGTAGACTAAGTGCTCTGTGTTCTCAGTCTTCCCTTTTTTTCTGCCCCCATTCTTACTTTGTCCCAGGCATGCAGAGAAAG
ATGGTGATATTTTAGGCCAGGAGTATACCTTGCTATAACCTAAGCATGCCTTCTTTATTCCAGCTCCTATGTTCTGTGTATATCATTAAC
ATTTTCCCAAATAAACACTTAATTCTCTTTTCCCTAGGTGCCATCTCCTCAAGCTACAAAATGTCCACATCTTATATCCCCTTTGCTTCT
ACTGCTCTGATTTTGTGGTACCAGTACTCTCTGCCACTGAACATTTTGAAATATTTTTGTTTTAGATTTGCAAAAAATGACATATAGGTC
AGTACTCACATGGATTTTTAAGATAAATCACCTGTGTGATAATATTTTGAATCTGAGACGAATACAACTTTTAAAAATTGTTTTTAAAAA
TAGACTTTTTTTTTTAGAGCAGTTGTAGGTTAACAGAAAAATTGAGAGGAAGATAGAGATTTCCTTTCTCCCCTGACAAAGCCCTCAACA
GCCTCCCAGGCTATCAGTATCCTGCACCACAATGGTACATTTGTTACAATCAATGAACCTACTCTGAAACATCATTATCATCCAAAGTTC
ATGGTTTACATTAGAGTCCCCTCTTGGTGTTATACATGCTAGAGGACAAATATATGATGATATGTATGCATCATTATAATATAGTATAGT
TTCGCTGCCCTAAACATCCTCTGCAAATGCAACTATTTTAATGGGTACCAAAGAAGTAAATGTATTTACTGGCTTTTAGATAATAAATAA
CGGGCTTTATTGTTTATTTTAAAAGCTACAATTTGTTTTAGCTGGTTTCTCTGTTCTATTAATGCTTTGAATTTCCAAATTTAATATATG
TAGTCATGCATTTAACTTAATATTTAATTATTTGATTTATTTAATTTTCTATATTCTTACAATGTATGTATGATGTATAATTTAAGGGAA

>81021_81021_5_SF1-TC2N_SF1_chr11_64543969_ENST00000377394_TC2N_chr14_92249554_ENST00000360594_length(amino acids)=177AA_BP=1
MCHLITTFSGFITVSFHWFTASMLLLSSLIQIYISSFLFSSKSRGNNCRHSWNHCLLFHCVLVPAAPLPLLTWEVQRRGVRSGRHGAPGD

--------------------------------------------------------------
>81021_81021_6_SF1-TC2N_SF1_chr11_64543969_ENST00000433274_TC2N_chr14_92249554_ENST00000340892_length(transcript)=3423nt_BP=391nt
GACGCAGTGAGGTGGCCGGGCTGTGCGGCGCAACTGTATAGACTGGGGGCCCACTATTGCTGTCCAGTCCGCTGGTGTCGGGAACAGGGG
TGGCGGGTGTTCAGCGCTGGACGGGGTGCTAGCTGTGAATGCCAGCAGGGCGTGAAAGCCTCACCTGATGACGTGCAGCGACTCCCTTCT
GGTCTTGAGGAACCAGAATGGGAACCGTACCAAGGATAGCTCCTCTGCTTCTACAGCAAGGCAGGGTTTTCATCCGGGAGAGACTTCCCA
AGTAAGAAGCGGAAGAGGAGCCGCTGGAACCAAGACACAATGGAACAGAAGACAGTGATTCCAGGAATGCCTACAGTTATTCCCCCTGGA
CTTACTCGAGAACAAGAAAGAGCTTATATAGATTTGGATAAGTGAAGACAGTAATAACATTGAAGCAGTGAACCAGTGGAAAGAGACAGT
AATAAATCCAGAAAAGGTTGTTATCAGGTGGCACAAATTAAATCCATCTTGAAGACTTCACACATTAATTTGGTGAAGAACTTGACATTC
TTTTAGAAGACTTATGATTTCAATTTGCTACCAATGAGAAGAGGCAAATCAACAAATTTGTCAATTTATGGGGGCTATAATTATGGTATA
TAATGTATCTGATAGAAAATTTGATAAGAAAATGTAATGAATTTTATCAGATATCCAAAGTAAAGGAAATGTTTTAAAACTGCAACAAGA
GACACAGACAGTAAAATCAAAGTATTATTAGGATGACTAAATAAATTATAAAGTCTGTGAGAATATCAACCATAGATAGTTCTTTCTATA
TTATGTTTTCGCTTTTGTATTTTAAGCTTTACTTAGATATTCAAAACCTGGTATATCAAGTCTCTGTTAGTACTATTGGCATTTAGAAGA
CTTTACCATTATTTCAGTGCTAGGCATTATTGATTAGGTCTTGGCTCCACTGTTTACCTCTTGCTATGTATTTTCTCCCGGTAAAAATGA
ATTGAACCATTTCAACTATTTTCTATATTTGGAGAAAGTTTGTGCCCTGTGTTTTATAATTTTTTTACCCATAAGACATCACATTATCCC
TTTGTAAGCTACTTATCTCCAAAAAACTTCAGAAATAGAAAACTACATTTTGGCAGGAATAATTGAAAACACCAGAAGGTTGAAGTTTAA
TTGGAAACCCAGAATATACATACTTTGCTGTTTTCTTCCCTCAAATATTTTACTATTTGTTTTATTTGGAGTTAAAATAAGAGTATCATC
CATATGGTCCATCCTAATTCACAGAATTAAATGAGCTTAAATAGAAAATTCAGTATTTTATGATAATCACTTCGTTTTTAGTTTTTAAAA
TTTAGATTATTCTATAATTTACCGTGTTTGAGTATTTTCTCATTTTTTTCATAACCATACCTGATTATACTGTGTAACAAATATTTTCTA
TTGCAGTTTTCTTTCCAGTACTTATTAGAACTCAGTATTTGGAAATAATTTCAGCTTAATTGACCATAAGAACTGTGGCCAAAAAGAACA
GTTTTTTGGAGAGGCAGATGACATTATACCTGATTTTAGAAAATCTCACTTTATTTTTGCTAATAAGTAGACTAAGTGCTCTGTGTTCTC
AGTCTTCCCTTTTTTTCTGCCCCCATTCTTACTTTGTCCCAGGCATGCAGAGAAAGATGGTGATATTTTAGGCCAGGAGTATACCTTGCT
ATAACCTAAGCATGCCTTCTTTATTCCAGCTCCTATGTTCTGTGTATATCATTAACATTTTCCCAAATAAACACTTAATTCTCTTTTCCC
TAGGTGCCATCTCCTCAAGCTACAAAATGTCCACATCTTATATCCCCTTTGCTTCTACTGCTCTGATTTTGTGGTACCAGTACTCTCTGC
CACTGAACATTTTGAAATATTTTTGTTTTAGATTTGCAAAAAATGACATATAGGTCAGTACTCACATGGATTTTTAAGATAAATCACCTG
TGTGATAATATTTTGAATCTGAGACGAATACAACTTTTAAAAATTGTTTTTAAAAATAGACTTTTTTTTTTAGAGCAGTTGTAGGTTAAC
AGAAAAATTGAGAGGAAGATAGAGATTTCCTTTCTCCCCTGACAAAGCCCTCAACAGCCTCCCAGGCTATCAGTATCCTGCACCACAATG
GTACATTTGTTACAATCAATGAACCTACTCTGAAACATCATTATCATCCAAAGTTCATGGTTTACATTAGAGTCCCCTCTTGGTGTTATA
CATGCTAGAGGACAAATATATGATGATATGTATGCATCATTATAATATAGTATAGTTTCGCTGCCCTAAACATCCTCTGCAAATGCAACT
ATTTTAATGGGTACCAAAGAAGTAAATGTATTTACTGGCTTTTAGATAATAAATAACGGGCTTTATTGTTTATTTTAAAAGCTACAATTT
GTTTTAGCTGGTTTCTCTGTTCTATTAATGCTTTGAATTTCCAAATTTAATATATGTAGTCATGCATTTAACTTAATATTTAATTATTTG
ATTTATTTAATTTTCTATATTCTTACAATGTATGTATGATGTATAATTTAAGGGAAAGCTATGACTTCTCAGTTTCTTAGAATCCTAGGT
AAATAAAACAATAAAAAGAAAACCCTTACATTTAAAAGAGCTTTCAGGTACAGAAGTATTGATACAACTAAGATCCTAAATGTTTTAATT
AGTGTTTACTTAAGCCTTTTTCAGGTGAGGAGGTACTAATGCTGGTTATTTCCTTGAAGCTTTATGTGGACCTATAAATAAAAATCCAAT
CTCCTGCTAATAGGTATGCATATTGTGAGAAAAACGTTAGGAGCTGGTAGTAAAAAATGAGATTCTATGCCAAAATAACTTCTCTTCATA
TTTGCCTAGGCATTTCTTGACCTTTACCCACTTACGCAAGGAGAAGGAAATCATAATGATGTCATGTGATCAAAGGAAACCATGGAAGGG
TTCACGCTGATAGCTGATAGCTTTTACAGTGCTCATTCCTAACAGTGGATTTACTTGTAAGCTTTCAGATCAACACAAATAGCTGCAGCC
TGGGTTAAAATATAACATCACTATTTGGCTTTTGTTTTGCATGATTTTTAAAAGCAGTACTCCTAGGGAAATGGCCTCTGAAGTATATCA
GTTTCATCTCTTACCAAGACTGTTAAGAAGAAACTAGTGGGATTTTGAACAAGTTATATAATTGTGGTCTGAAAAGACCCTAAACTGAAG
TTCTGTTTAAATATAGTTACATGAATTTCTCTGATACTAATGTACTCAACAGCCAGGTATAAACTATATCTCCTAGTAACATTTTCCATT
TTTGTTTAATCAAATACTTGCTTATGAAGGATTTCAGAAATTTGTAATAAATGTCAGCTTTTGATAGCATAGCAGTAATTGACATTTCAA

>81021_81021_6_SF1-TC2N_SF1_chr11_64543969_ENST00000433274_TC2N_chr14_92249554_ENST00000340892_length(amino acids)=78AA_BP=1

--------------------------------------------------------------
>81021_81021_7_SF1-TC2N_SF1_chr11_64543969_ENST00000433274_TC2N_chr14_92249554_ENST00000435962_length(transcript)=3851nt_BP=391nt
GACGCAGTGAGGTGGCCGGGCTGTGCGGCGCAACTGTATAGACTGGGGGCCCACTATTGCTGTCCAGTCCGCTGGTGTCGGGAACAGGGG
TGGCGGGTGTTCAGCGCTGGACGGGGTGCTAGCTGTGAATGCCAGCAGGGCGTGAAAGCCTCACCTGATGACGTGCAGCGACTCCCTTCT
GGTCTTGAGGAACCAGAATGGGAACCGTACCAAGGATAGCTCCTCTGCTTCTACAGCAAGGCAGGGTTTTCATCCGGGAGAGACTTCCCA
AGTAAGAAGCGGAAGAGGAGCCGCTGGAACCAAGACACAATGGAACAGAAGACAGTGATTCCAGGAATGCCTACAGTTATTCCCCCTGGA
CTTACTCGAGAACAAGAAAGAGCTTATATAGATTTGGATAAGTGAAGACAGTAATAACATTGAAGCAGTGAACCAGTGGAAAGAGACAGT
AATAAATCCAGAAAAGGTTGTTATCAGGTGGCACAAATTAAATCCATCTTGAAGACTTCACACATTAATTTGGTGAAGAACTTGACATTC
TTTTAGAAGACTTATGATTTCAATTTGCTACCAATGAGAAGAGGCAAATCAACAAATTTGTCAATTTATGGGGGCTATAATTATGGTATA
TAATGTATCTGATAGAAAATTTGATAAGAAAATGTAATGAATTTTATCAGATATCCAAAGTAAAGGAAATGTTTTAAAACTGCAACAAGA
GACACAGACAGTAAAATCAAAGTATTATTAGGATGACTAAATAAATTATAAAGTCTGTGAGAATATCAACCATAGATAGTTCTTTCTATA
TTATGTTTTCGCTTTTGTATTTTAAGCTTTACTTAGATATTCAAAACCTGGTATATCAAGTCTCTGTTAGTACTATTGGCATTTAGAAGA
CTTTACCATTATTTCAGTGCTAGGCATTATTGATTAGGTCTTGGCTCCACTGTTTACCTCTTGCTATGTATTTTCTCCCGGTAAAAATGA
ATTGAACCATTTCAACTATTTTCTATATTTGGAGAAAGTTTGTGCCCTGTGTTTTATAATTTTTTTACCCATAAGACATCACATTATCCC
TTTGTAAGCTACTTATCTCCAAAAAACTTCAGAAATAGAAAACTACATTTTGGCAGGAATAATTGAAAACACCAGAAGGTTGAAGTTTAA
TTGGAAACCCAGAATATACATACTTTGCTGTTTTCTTCCCTCAAATATTTTACTATTTGTTTTATTTGGAGTTAAAATAAGAGTATCATC
CATATGGTCCATCCTAATTCACAGAATTAAATGAGCTTAAATAGAAAATTCAGTATTTTATGATAATCACTTCGTTTTTAGTTTTTAAAA
TTTAGATTATTCTATAATTTACCGTGTTTGAGTATTTTCTCATTTTTTTCATAACCATACCTGATTATACTGTGTAACAAATATTTTCTA
TTGCAGTTTTCTTTCCAGTACTTATTAGAACTCAGTATTTGGAAATAATTTCAGCTTAATTGACCATAAGAACTGTGGCCAAAAAGAACA
GTTTTTTGGAGAGGCAGATGACATTATACCTGATTTTAGAAAATCTCACTTTATTTTTGCTAATAAGTAGACTAAGTGCTCTGTGTTCTC
AGTCTTCCCTTTTTTTCTGCCCCCATTCTTACTTTGTCCCAGGCATGCAGAGAAAGATGGTGATATTTTAGGCCAGGAGTATACCTTGCT
ATAACCTAAGCATGCCTTCTTTATTCCAGCTCCTATGTTCTGTGTATATCATTAACATTTTCCCAAATAAACACTTAATTCTCTTTTCCC
TAGGTGCCATCTCCTCAAGCTACAAAATGTCCACATCTTATATCCCCTTTGCTTCTACTGCTCTGATTTTGTGGTACCAGTACTCTCTGC
CACTGAACATTTTGAAATATTTTTGTTTTAGATTTGCAAAAAATGACATATAGGTCAGTACTCACATGGATTTTTAAGATAAATCACCTG
TGTGATAATATTTTGAATCTGAGACGAATACAACTTTTAAAAATTGTTTTTAAAAATAGACTTTTTTTTTTAGAGCAGTTGTAGGTTAAC
AGAAAAATTGAGAGGAAGATAGAGATTTCCTTTCTCCCCTGACAAAGCCCTCAACAGCCTCCCAGGCTATCAGTATCCTGCACCACAATG
GTACATTTGTTACAATCAATGAACCTACTCTGAAACATCATTATCATCCAAAGTTCATGGTTTACATTAGAGTCCCCTCTTGGTGTTATA
CATGCTAGAGGACAAATATATGATGATATGTATGCATCATTATAATATAGTATAGTTTCGCTGCCCTAAACATCCTCTGCAAATGCAACT
ATTTTAATGGGTACCAAAGAAGTAAATGTATTTACTGGCTTTTAGATAATAAATAACGGGCTTTATTGTTTATTTTAAAAGCTACAATTT
GTTTTAGCTGGTTTCTCTGTTCTATTAATGCTTTGAATTTCCAAATTTAATATATGTAGTCATGCATTTAACTTAATATTTAATTATTTG
ATTTATTTAATTTTCTATATTCTTACAATGTATGTATGATGTATAATTTAAGGGAAAGCTATGACTTCTCAGTTTCTTAGAATCCTAGGT
AAATAAAACAATAAAAAGAAAACCCTTACATTTAAAAGAGCTTTCAGGTACAGAAGTATTGATACAACTAAGATCCTAAATGTTTTAATT
AGTGTTTACTTAAGCCTTTTTCAGGTGAGGAGGTACTAATGCTGGTTATTTCCTTGAAGCTTTATGTGGACCTATAAATAAAAATCCAAT
CTCCTGCTAATAGGTATGCATATTGTGAGAAAAACGTTAGGAGCTGGTAGTAAAAAATGAGATTCTATGCCAAAATAACTTCTCTTCATA
TTTGCCTAGGCATTTCTTGACCTTTACCCACTTACGCAAGGAGAAGGAAATCATAATGATGTCATGTGATCAAAGGAAACCATGGAAGGG
TTCACGCTGATAGCTGATAGCTTTTACAGTGCTCATTCCTAACAGTGGATTTACTTGTAAGCTTTCAGATCAACACAAATAGCTGCAGCC
TGGGTTAAAATATAACATCACTATTTGGCTTTTGTTTTGCATGATTTTTAAAAGCAGTACTCCTAGGGAAATGGCCTCTGAAGTATATCA
GTTTCATCTCTTACCAAGACTGTTAAGAAGAAACTAGTGGGATTTTGAACAAGTTATATAATTGTGGTCTGAAAAGACCCTAAACTGAAG
TTCTGTTTAAATATAGTTACATGAATTTCTCTGATACTAATGTACTCAACAGCCAGGTATAAACTATATCTCCTAGTAACATTTTCCATT
TTTGTTTAATCAAATACTTGCTTATGAAGGATTTCAGAAATTTGTAATAAATGTCAGCTTTTGATAGCATAGCAGTAATTGACATTTCAA
AAATATATATTTCTTTCTGTGTTTGGTTGGGTGTAATGAGGAAAATACCTGATAAAATGTCTGAAGACACTTTCTAATGTTATCTTGGTG
CATAAGCTGTAATTTTTATTCAAAATTAAATTTCAAATGTTTGCAGTTTTGGCTAAAACATTGAGTTGAAAGAATTATGAAAAGTGGGCC
CATATGAAGTACCATGTTCATTTTGAAATATAGATTTAAGATTTAGAAATATATTAAAAGAGTTAATGGAGCCTCCTAAATTGGATTTTA
TTTTGTGGGTGAAGAATTGTAGGAAGATGAATGTGGCCTACAGTTTTAGTAATCTCCTAGTGGAGTTTTTTTTAACTTAGTACTTTTTTA

>81021_81021_7_SF1-TC2N_SF1_chr11_64543969_ENST00000433274_TC2N_chr14_92249554_ENST00000435962_length(amino acids)=78AA_BP=1

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Fusion Gene PPI Analysis for SF1-TC2N


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SF1-TC2N


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SF1-TC2N


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource