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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SF3A1-PES1 (FusionGDB2 ID:81026)

Fusion Gene Summary for SF3A1-PES1

check button Fusion gene summary
Fusion gene informationFusion gene name: SF3A1-PES1
Fusion gene ID: 81026
HgeneTgene
Gene symbol

SF3A1

PES1

Gene ID

10291

23481

Gene namesplicing factor 3a subunit 1pescadillo ribosomal biogenesis factor 1
SynonymsPRP21|PRPF21|SAP114|SF3A120NOP7|PES
Cytomap

22q12.2

22q12.2

Type of geneprotein-codingprotein-coding
Descriptionsplicing factor 3A subunit 1SAP 114pre-mRNA processing 21pre-mRNA splicing factor SF3a (120 kDa subunit)spliceosome-associated protein 114splicing factor 3 subunit 1splicing factor 3a, subunit 1, 120kDsplicing factor 3a, subunit 1, 120kDapescadillo homologpescadillo homolog 1, containing BRCT domain
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000215793, ENST00000439242, 
ENST00000492986, ENST00000335214, 
ENST00000402281, ENST00000354694, 
ENST00000402284, ENST00000405677, 
Fusion gene scores* DoF score4 X 4 X 3=485 X 4 X 3=60
# samples 45
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SF3A1 [Title/Abstract] AND PES1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSF3A1(30733015)-PES1(30973116), # samples:1
Anticipated loss of major functional domain due to fusion event.SF3A1-PES1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSF3A1

GO:0000398

mRNA splicing, via spliceosome

10882114|29360106

HgeneSF3A1

GO:1903241

U2-type prespliceosome assembly

10882114|11533230


check buttonFusion gene breakpoints across SF3A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PES1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3BD-01ASF3A1chr22

30733015

-PES1chr22

30973116

-


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Fusion Gene ORF analysis for SF3A1-PES1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000215793ENST00000492986SF3A1chr22

30733015

-PES1chr22

30973116

-
5CDS-intronENST00000439242ENST00000492986SF3A1chr22

30733015

-PES1chr22

30973116

-
Frame-shiftENST00000215793ENST00000335214SF3A1chr22

30733015

-PES1chr22

30973116

-
Frame-shiftENST00000215793ENST00000402281SF3A1chr22

30733015

-PES1chr22

30973116

-
Frame-shiftENST00000439242ENST00000335214SF3A1chr22

30733015

-PES1chr22

30973116

-
Frame-shiftENST00000439242ENST00000402281SF3A1chr22

30733015

-PES1chr22

30973116

-
In-frameENST00000215793ENST00000354694SF3A1chr22

30733015

-PES1chr22

30973116

-
In-frameENST00000215793ENST00000402284SF3A1chr22

30733015

-PES1chr22

30973116

-
In-frameENST00000215793ENST00000405677SF3A1chr22

30733015

-PES1chr22

30973116

-
In-frameENST00000439242ENST00000354694SF3A1chr22

30733015

-PES1chr22

30973116

-
In-frameENST00000439242ENST00000402284SF3A1chr22

30733015

-PES1chr22

30973116

-
In-frameENST00000439242ENST00000405677SF3A1chr22

30733015

-PES1chr22

30973116

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000215793SF3A1chr2230733015-ENST00000354694PES1chr2230973116-276622611312344737
ENST00000215793SF3A1chr2230733015-ENST00000405677PES1chr2230973116-275922611312344737
ENST00000215793SF3A1chr2230733015-ENST00000402284PES1chr2230973116-272622611312344737
ENST00000439242SF3A1chr2230733015-ENST00000354694PES1chr2230973116-254820431082126672
ENST00000439242SF3A1chr2230733015-ENST00000405677PES1chr2230973116-254120431082126672
ENST00000439242SF3A1chr2230733015-ENST00000402284PES1chr2230973116-250820431082126672

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000215793ENST00000354694SF3A1chr2230733015-PES1chr2230973116-0.0140017640.9859983
ENST00000215793ENST00000405677SF3A1chr2230733015-PES1chr2230973116-0.0141697010.98583025
ENST00000215793ENST00000402284SF3A1chr2230733015-PES1chr2230973116-0.0144006050.9855994
ENST00000439242ENST00000354694SF3A1chr2230733015-PES1chr2230973116-0.0139317350.98606825
ENST00000439242ENST00000405677SF3A1chr2230733015-PES1chr2230973116-0.0140626490.9859373
ENST00000439242ENST00000402284SF3A1chr2230733015-PES1chr2230973116-0.0145233030.9854767

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Fusion Genomic Features for SF3A1-PES1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SF3A1-PES1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:30733015/chr22:30973116)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSF3A1chr22:30733015chr22:30973116ENST00000215793-131610_16702794.0Compositional biasNote=Poly-Pro
HgeneSF3A1chr22:30733015chr22:30973116ENST00000215793-1316118_122702794.0Compositional biasNote=Poly-Gln
HgeneSF3A1chr22:30733015chr22:30973116ENST00000215793-1316260_267702794.0Compositional biasNote=Poly-Glu
HgeneSF3A1chr22:30733015chr22:30973116ENST00000215793-1316369_372702794.0Compositional biasNote=Poly-Pro
HgeneSF3A1chr22:30733015chr22:30973116ENST00000215793-1316557_560702794.0Compositional biasNote=Poly-Pro
HgeneSF3A1chr22:30733015chr22:30973116ENST00000215793-1316672_675702794.0Compositional biasNote=Poly-Pro
HgeneSF3A1chr22:30733015chr22:30973116ENST00000215793-1316680_702702794.0RegionRequired and sufficient for nuclear import
HgeneSF3A1chr22:30733015chr22:30973116ENST00000215793-1316166_208702794.0RepeatNote=SURP motif 2
HgeneSF3A1chr22:30733015chr22:30973116ENST00000215793-131652_94702794.0RepeatNote=SURP motif 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSF3A1chr22:30733015chr22:30973116ENST00000215793-1316707_793702794.0DomainUbiquitin-like
TgenePES1chr22:30733015chr22:30973116ENST000003352141315456_531556584.0Compositional biasNote=Glu-rich
TgenePES1chr22:30733015chr22:30973116ENST000003546941315456_531561589.0Compositional biasNote=Glu-rich
TgenePES1chr22:30733015chr22:30973116ENST000003352141315322_415556584.0DomainBRCT
TgenePES1chr22:30733015chr22:30973116ENST000003546941315322_415561589.0DomainBRCT
TgenePES1chr22:30733015chr22:30973116ENST0000033521413151_257556584.0RegionNote=Sufficient for nucleolar localization
TgenePES1chr22:30733015chr22:30973116ENST0000033521413151_54556584.0RegionNote=Required for 28S ribosomal RNA processing
TgenePES1chr22:30733015chr22:30973116ENST000003352141315539_588556584.0RegionNote=Required for 28S ribosomal RNA processing
TgenePES1chr22:30733015chr22:30973116ENST0000035469413151_257561589.0RegionNote=Sufficient for nucleolar localization
TgenePES1chr22:30733015chr22:30973116ENST0000035469413151_54561589.0RegionNote=Required for 28S ribosomal RNA processing
TgenePES1chr22:30733015chr22:30973116ENST000003546941315539_588561589.0RegionNote=Required for 28S ribosomal RNA processing


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Fusion Gene Sequence for SF3A1-PES1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81026_81026_1_SF3A1-PES1_SF3A1_chr22_30733015_ENST00000215793_PES1_chr22_30973116_ENST00000354694_length(transcript)=2766nt_BP=2261nt
GGTCCCGGAAGTGCGCCAGTCGTACCTTCGCGGCCGCAACTCGCTCGGCCGCCGCCATCTTGCGAGCTCGTCGTACTGACCGAGCGGGGA
GGCTGTCTTGAGGCGGCACCGCTCACCGACACCGAGGCGGACTGGCAGCCCTGAGCGTCGCAGTCATGCCGGCCGGACCCGTGCAGGCGG
TGCCCCCGCCGCCGCCCGTGCCCACGGAGCCCAAACAGCCCACAGAAGAAGAAGCATCTTCAAAGGAGGATTCTGCACCTTCTAAGCCAG
TTGTGGGGATTATTTACCCTCCTCCAGAGGTCAGAAATATTGTTGACAAGACTGCCAGCTTTGTGGCCAGAAACGGGCCTGAATTTGAAG
CTAGGATCCGACAGAACGAGATCAACAACCCCAAGTTCAACTTTCTGAACCCCAATGACCCTTACCATGCCTACTACCGCCACAAGGTCA
GCGAGTTCAAGGAAGGGAAGGCTCAGGAGCCGTCCGCCGCCATCCCCAAGGTCATGCAGCAGCAGCAGCAGACCACCCAGCAGCAGCTGC
CCCAGAAGGTCCAAGCCCAAGTAATCCAAGAGACCATCGTGCCCAAAGAGCCTCCTCCTGAGTTTGAGTTCATTGCTGATCCTCCCTCTA
TCTCAGCCTTCGACTTGGATGTGGTGAAGCTGACGGCTCAGTTTGTGGCCAGGAATGGGCGCCAGTTTCTGACCCAGCTGATGCAGAAAG
AGCAGCGCAACTACCAGTTTGACTTTCTCCGCCCACAGCACAGCCTCTTCAACTACTTCACGAAGCTAGTGGAACAGTACACCAAGATCT
TGATTCCACCCAAAGGTTTATTTTCAAAGCTCAAGAAAGAGGCTGAAAACCCCCGAGAAGTTTTGGATCAGGTGTGTTACCGAGTGGAAT
GGGCCAAATTCCAGGAACGTGAGAGGAAGAAGGAAGAAGAGGAGAAGGAGAAGGAGCGGGTGGCCTATGCTCAGATCGACTGGCATGATT
TTGTGGTGGTGGAAACAGTGGACTTCCAACCCAATGAGCAAGGGAACTTCCCTCCCCCCACCACGCCAGAGGAGCTGGGGGCCCGAATCC
TCATTCAGGAGCGCTATGAAAAGTTTGGGGAGAGTGAGGAAGTTGAGATGGAGGTCGAGTCTGATGAGGAGGATGACAAACAGGAGAAGG
CGGAGGAGCCTCCTTCCCAGCTGGACCAGGACACCCAAGTACAAGATATGGATGAGGGTTCAGATGATGAAGAAGAAGGGCAGAAAGTGC
CCCCACCCCCAGAGACACCCATGCCTCCACCTCTGCCCCCAACTCCAGACCAAGTCATTGTCCGCAAGGATTATGATCCCAAAGCCTCCA
AGCCCTTGCCTCCAGCCCCTGCTCCAGATGAGTATCTTGTGTCCCCCATTACTGGGGAGAAGATCCCCGCCAGCAAAATGCAGGAACACA
TGCGCATTGGACTTCTTGACCCTCGCTGGCTGGAGCAGCGGGATCGCTCCATCCGTGAGAAGCAGAGCGATGATGAGGTGTACGCACCAG
GTCTGGATATTGAGAGCAGCTTGAAGCAGTTGGCTGAGCGGCGTACTGACATCTTCGGTGTAGAGGAAACAGCCATTGGTAAGAAGATCG
GTGAGGAGGAGATCCAGAAGCCAGAGGAAAAGGTGACCTGGGATGGCCACTCAGGCAGCATGGCCCGGACCCAGCAGGCTGCCCAGGCCA
ACATCACCCTCCAGGAGCAGATTGAGGCCATTCACAAGGCCAAAGGCCTGGTGCCAGAGGATGACACTAAAGAGAAGATTGGCCCCAGCA
AGCCCAATGAAATCCCTCAACAGCCACCGCCACCATCTTCAGCCACCAACATCCCCAGCTCGGCTCCACCCATCACTTCAGTGCCCCGAC
CACCCACAATGCCACCTCCAGTTCGTACTACAGTTGTCTCCGCAGTACCCGTCATGCCCCGGCCCCCAATGGCATCTGTGGTCCGGCTGC
CCCCAGGCTCAGTGATCGCCCCCATGCCGCCCATCATCCACGCGCCCAGAATCAACGTGGTGCCCATGCCTCCCTCGGCCCCTCCTATTA
TGGCCCCCCGCCCACCCCCCATGATTGTGCCAACAGCCTTTGTGCCTGCTCCACCTGTGGCACCTGTCCCAGCTCCAGCCCCAATGCCCC
CTGTGCATCCCCCACCTCCCATGGAAGATGAGCCCACCTCCAAAAAACTGAAGACAGAGGACAGCCTCATGCCAGAGGAGGAGTTCCTGC
GCAGAAACAAGGCCAACAAGCTGGCGGAGAAGCGGAAAGCCCACGATGAGGCGGTGAGGTCTGAGAAGAAGGCCAAGAAGGCAAGGCCGG
AGTGAGTGCCTGCGGCCCCTCACAGGGCTGAGGCCAGCCCCTAGCAGCTGGATGTGGCAGAGGCAGGCCAGAGGACCTAAGTGTGATGGA
CCAGAGTCACTTCTCCTCCTCCTTTCTCCAGCCAGCCCTGACCCCTCATGCTCTCTGGCTGGGCCAGTGGGCAGCCCTCGCTTCCCTTGG
ATGGAGCTGCCCTGCTGGTGCCTGGTCAGAGAAGAGGCCTCTGTGCCCAGCCTGATTCTCTGCTCCCAGGAGCCAGTGACATGAGGTGCA
GAGGCCCACCCAGCCCCCTACCTACTGCCCCCATTCATCCTGGCTTTCCACAGCCCCCTCCCACACAGTTGGACCCGTGATTCTCAGGGT

>81026_81026_1_SF3A1-PES1_SF3A1_chr22_30733015_ENST00000215793_PES1_chr22_30973116_ENST00000354694_length(amino acids)=737AA_BP=710
MAALSVAVMPAGPVQAVPPPPPVPTEPKQPTEEEASSKEDSAPSKPVVGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNEINNPKFN
FLNPNDPYHAYYRHKVSEFKEGKAQEPSAAIPKVMQQQQQTTQQQLPQKVQAQVIQETIVPKEPPPEFEFIADPPSISAFDLDVVKLTAQ
FVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTKILIPPKGLFSKLKKEAENPREVLDQVCYRVEWAKFQERERKKEEE
EKEKERVAYAQIDWHDFVVVETVDFQPNEQGNFPPPTTPEELGARILIQERYEKFGESEEVEMEVESDEEDDKQEKAEEPPSQLDQDTQV
QDMDEGSDDEEEGQKVPPPPETPMPPPLPPTPDQVIVRKDYDPKASKPLPPAPAPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQR
DRSIREKQSDDEVYAPGLDIESSLKQLAERRTDIFGVEETAIGKKIGEEEIQKPEEKVTWDGHSGSMARTQQAAQANITLQEQIEAIHKA
KGLVPEDDTKEKIGPSKPNEIPQQPPPPSSATNIPSSAPPITSVPRPPTMPPPVRTTVVSAVPVMPRPPMASVVRLPPGSVIAPMPPIIH
APRINVVPMPPSAPPIMAPRPPPMIVPTAFVPAPPVAPVPAPAPMPPVHPPPPMEDEPTSKKLKTEDSLMPEEEFLRRNKANKLAEKRKA

--------------------------------------------------------------
>81026_81026_2_SF3A1-PES1_SF3A1_chr22_30733015_ENST00000215793_PES1_chr22_30973116_ENST00000402284_length(transcript)=2726nt_BP=2261nt
GGTCCCGGAAGTGCGCCAGTCGTACCTTCGCGGCCGCAACTCGCTCGGCCGCCGCCATCTTGCGAGCTCGTCGTACTGACCGAGCGGGGA
GGCTGTCTTGAGGCGGCACCGCTCACCGACACCGAGGCGGACTGGCAGCCCTGAGCGTCGCAGTCATGCCGGCCGGACCCGTGCAGGCGG
TGCCCCCGCCGCCGCCCGTGCCCACGGAGCCCAAACAGCCCACAGAAGAAGAAGCATCTTCAAAGGAGGATTCTGCACCTTCTAAGCCAG
TTGTGGGGATTATTTACCCTCCTCCAGAGGTCAGAAATATTGTTGACAAGACTGCCAGCTTTGTGGCCAGAAACGGGCCTGAATTTGAAG
CTAGGATCCGACAGAACGAGATCAACAACCCCAAGTTCAACTTTCTGAACCCCAATGACCCTTACCATGCCTACTACCGCCACAAGGTCA
GCGAGTTCAAGGAAGGGAAGGCTCAGGAGCCGTCCGCCGCCATCCCCAAGGTCATGCAGCAGCAGCAGCAGACCACCCAGCAGCAGCTGC
CCCAGAAGGTCCAAGCCCAAGTAATCCAAGAGACCATCGTGCCCAAAGAGCCTCCTCCTGAGTTTGAGTTCATTGCTGATCCTCCCTCTA
TCTCAGCCTTCGACTTGGATGTGGTGAAGCTGACGGCTCAGTTTGTGGCCAGGAATGGGCGCCAGTTTCTGACCCAGCTGATGCAGAAAG
AGCAGCGCAACTACCAGTTTGACTTTCTCCGCCCACAGCACAGCCTCTTCAACTACTTCACGAAGCTAGTGGAACAGTACACCAAGATCT
TGATTCCACCCAAAGGTTTATTTTCAAAGCTCAAGAAAGAGGCTGAAAACCCCCGAGAAGTTTTGGATCAGGTGTGTTACCGAGTGGAAT
GGGCCAAATTCCAGGAACGTGAGAGGAAGAAGGAAGAAGAGGAGAAGGAGAAGGAGCGGGTGGCCTATGCTCAGATCGACTGGCATGATT
TTGTGGTGGTGGAAACAGTGGACTTCCAACCCAATGAGCAAGGGAACTTCCCTCCCCCCACCACGCCAGAGGAGCTGGGGGCCCGAATCC
TCATTCAGGAGCGCTATGAAAAGTTTGGGGAGAGTGAGGAAGTTGAGATGGAGGTCGAGTCTGATGAGGAGGATGACAAACAGGAGAAGG
CGGAGGAGCCTCCTTCCCAGCTGGACCAGGACACCCAAGTACAAGATATGGATGAGGGTTCAGATGATGAAGAAGAAGGGCAGAAAGTGC
CCCCACCCCCAGAGACACCCATGCCTCCACCTCTGCCCCCAACTCCAGACCAAGTCATTGTCCGCAAGGATTATGATCCCAAAGCCTCCA
AGCCCTTGCCTCCAGCCCCTGCTCCAGATGAGTATCTTGTGTCCCCCATTACTGGGGAGAAGATCCCCGCCAGCAAAATGCAGGAACACA
TGCGCATTGGACTTCTTGACCCTCGCTGGCTGGAGCAGCGGGATCGCTCCATCCGTGAGAAGCAGAGCGATGATGAGGTGTACGCACCAG
GTCTGGATATTGAGAGCAGCTTGAAGCAGTTGGCTGAGCGGCGTACTGACATCTTCGGTGTAGAGGAAACAGCCATTGGTAAGAAGATCG
GTGAGGAGGAGATCCAGAAGCCAGAGGAAAAGGTGACCTGGGATGGCCACTCAGGCAGCATGGCCCGGACCCAGCAGGCTGCCCAGGCCA
ACATCACCCTCCAGGAGCAGATTGAGGCCATTCACAAGGCCAAAGGCCTGGTGCCAGAGGATGACACTAAAGAGAAGATTGGCCCCAGCA
AGCCCAATGAAATCCCTCAACAGCCACCGCCACCATCTTCAGCCACCAACATCCCCAGCTCGGCTCCACCCATCACTTCAGTGCCCCGAC
CACCCACAATGCCACCTCCAGTTCGTACTACAGTTGTCTCCGCAGTACCCGTCATGCCCCGGCCCCCAATGGCATCTGTGGTCCGGCTGC
CCCCAGGCTCAGTGATCGCCCCCATGCCGCCCATCATCCACGCGCCCAGAATCAACGTGGTGCCCATGCCTCCCTCGGCCCCTCCTATTA
TGGCCCCCCGCCCACCCCCCATGATTGTGCCAACAGCCTTTGTGCCTGCTCCACCTGTGGCACCTGTCCCAGCTCCAGCCCCAATGCCCC
CTGTGCATCCCCCACCTCCCATGGAAGATGAGCCCACCTCCAAAAAACTGAAGACAGAGGACAGCCTCATGCCAGAGGAGGAGTTCCTGC
GCAGAAACAAGGCCAACAAGCTGGCGGAGAAGCGGAAAGCCCACGATGAGGCGGTGAGGTCTGAGAAGAAGGCCAAGAAGGCAAGGCCGG
AGTGAGTGCCTGCGGCCCCTCACAGGGCTGAGGCCAGCCCCTAGCAGCTGGATGTGGCAGAGGCAGGCCAGAGGACCTAAGTGTGATGGA
CCAGAGTCACTTCTCCTCCTCCTTTCTCCAGCCAGCCCTGACCCCTCATGCTCTCTGGCTGGGCCAGTGGGCAGCCCTCGCTTCCCTTGG
ATGGAGCTGCCCTGCTGGTGCCTGGTCAGAGAAGAGGCCTCTGTGCCCAGCCTGATTCTCTGCTCCCAGGAGCCAGTGACATGAGGTGCA
GAGGCCCACCCAGCCCCCTACCTACTGCCCCCATTCATCCTGGCTTTCCACAGCCCCCTCCCACACAGTTGGACCCGTGATTCTCAGGGT

>81026_81026_2_SF3A1-PES1_SF3A1_chr22_30733015_ENST00000215793_PES1_chr22_30973116_ENST00000402284_length(amino acids)=737AA_BP=710
MAALSVAVMPAGPVQAVPPPPPVPTEPKQPTEEEASSKEDSAPSKPVVGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNEINNPKFN
FLNPNDPYHAYYRHKVSEFKEGKAQEPSAAIPKVMQQQQQTTQQQLPQKVQAQVIQETIVPKEPPPEFEFIADPPSISAFDLDVVKLTAQ
FVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTKILIPPKGLFSKLKKEAENPREVLDQVCYRVEWAKFQERERKKEEE
EKEKERVAYAQIDWHDFVVVETVDFQPNEQGNFPPPTTPEELGARILIQERYEKFGESEEVEMEVESDEEDDKQEKAEEPPSQLDQDTQV
QDMDEGSDDEEEGQKVPPPPETPMPPPLPPTPDQVIVRKDYDPKASKPLPPAPAPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQR
DRSIREKQSDDEVYAPGLDIESSLKQLAERRTDIFGVEETAIGKKIGEEEIQKPEEKVTWDGHSGSMARTQQAAQANITLQEQIEAIHKA
KGLVPEDDTKEKIGPSKPNEIPQQPPPPSSATNIPSSAPPITSVPRPPTMPPPVRTTVVSAVPVMPRPPMASVVRLPPGSVIAPMPPIIH
APRINVVPMPPSAPPIMAPRPPPMIVPTAFVPAPPVAPVPAPAPMPPVHPPPPMEDEPTSKKLKTEDSLMPEEEFLRRNKANKLAEKRKA

--------------------------------------------------------------
>81026_81026_3_SF3A1-PES1_SF3A1_chr22_30733015_ENST00000215793_PES1_chr22_30973116_ENST00000405677_length(transcript)=2759nt_BP=2261nt
GGTCCCGGAAGTGCGCCAGTCGTACCTTCGCGGCCGCAACTCGCTCGGCCGCCGCCATCTTGCGAGCTCGTCGTACTGACCGAGCGGGGA
GGCTGTCTTGAGGCGGCACCGCTCACCGACACCGAGGCGGACTGGCAGCCCTGAGCGTCGCAGTCATGCCGGCCGGACCCGTGCAGGCGG
TGCCCCCGCCGCCGCCCGTGCCCACGGAGCCCAAACAGCCCACAGAAGAAGAAGCATCTTCAAAGGAGGATTCTGCACCTTCTAAGCCAG
TTGTGGGGATTATTTACCCTCCTCCAGAGGTCAGAAATATTGTTGACAAGACTGCCAGCTTTGTGGCCAGAAACGGGCCTGAATTTGAAG
CTAGGATCCGACAGAACGAGATCAACAACCCCAAGTTCAACTTTCTGAACCCCAATGACCCTTACCATGCCTACTACCGCCACAAGGTCA
GCGAGTTCAAGGAAGGGAAGGCTCAGGAGCCGTCCGCCGCCATCCCCAAGGTCATGCAGCAGCAGCAGCAGACCACCCAGCAGCAGCTGC
CCCAGAAGGTCCAAGCCCAAGTAATCCAAGAGACCATCGTGCCCAAAGAGCCTCCTCCTGAGTTTGAGTTCATTGCTGATCCTCCCTCTA
TCTCAGCCTTCGACTTGGATGTGGTGAAGCTGACGGCTCAGTTTGTGGCCAGGAATGGGCGCCAGTTTCTGACCCAGCTGATGCAGAAAG
AGCAGCGCAACTACCAGTTTGACTTTCTCCGCCCACAGCACAGCCTCTTCAACTACTTCACGAAGCTAGTGGAACAGTACACCAAGATCT
TGATTCCACCCAAAGGTTTATTTTCAAAGCTCAAGAAAGAGGCTGAAAACCCCCGAGAAGTTTTGGATCAGGTGTGTTACCGAGTGGAAT
GGGCCAAATTCCAGGAACGTGAGAGGAAGAAGGAAGAAGAGGAGAAGGAGAAGGAGCGGGTGGCCTATGCTCAGATCGACTGGCATGATT
TTGTGGTGGTGGAAACAGTGGACTTCCAACCCAATGAGCAAGGGAACTTCCCTCCCCCCACCACGCCAGAGGAGCTGGGGGCCCGAATCC
TCATTCAGGAGCGCTATGAAAAGTTTGGGGAGAGTGAGGAAGTTGAGATGGAGGTCGAGTCTGATGAGGAGGATGACAAACAGGAGAAGG
CGGAGGAGCCTCCTTCCCAGCTGGACCAGGACACCCAAGTACAAGATATGGATGAGGGTTCAGATGATGAAGAAGAAGGGCAGAAAGTGC
CCCCACCCCCAGAGACACCCATGCCTCCACCTCTGCCCCCAACTCCAGACCAAGTCATTGTCCGCAAGGATTATGATCCCAAAGCCTCCA
AGCCCTTGCCTCCAGCCCCTGCTCCAGATGAGTATCTTGTGTCCCCCATTACTGGGGAGAAGATCCCCGCCAGCAAAATGCAGGAACACA
TGCGCATTGGACTTCTTGACCCTCGCTGGCTGGAGCAGCGGGATCGCTCCATCCGTGAGAAGCAGAGCGATGATGAGGTGTACGCACCAG
GTCTGGATATTGAGAGCAGCTTGAAGCAGTTGGCTGAGCGGCGTACTGACATCTTCGGTGTAGAGGAAACAGCCATTGGTAAGAAGATCG
GTGAGGAGGAGATCCAGAAGCCAGAGGAAAAGGTGACCTGGGATGGCCACTCAGGCAGCATGGCCCGGACCCAGCAGGCTGCCCAGGCCA
ACATCACCCTCCAGGAGCAGATTGAGGCCATTCACAAGGCCAAAGGCCTGGTGCCAGAGGATGACACTAAAGAGAAGATTGGCCCCAGCA
AGCCCAATGAAATCCCTCAACAGCCACCGCCACCATCTTCAGCCACCAACATCCCCAGCTCGGCTCCACCCATCACTTCAGTGCCCCGAC
CACCCACAATGCCACCTCCAGTTCGTACTACAGTTGTCTCCGCAGTACCCGTCATGCCCCGGCCCCCAATGGCATCTGTGGTCCGGCTGC
CCCCAGGCTCAGTGATCGCCCCCATGCCGCCCATCATCCACGCGCCCAGAATCAACGTGGTGCCCATGCCTCCCTCGGCCCCTCCTATTA
TGGCCCCCCGCCCACCCCCCATGATTGTGCCAACAGCCTTTGTGCCTGCTCCACCTGTGGCACCTGTCCCAGCTCCAGCCCCAATGCCCC
CTGTGCATCCCCCACCTCCCATGGAAGATGAGCCCACCTCCAAAAAACTGAAGACAGAGGACAGCCTCATGCCAGAGGAGGAGTTCCTGC
GCAGAAACAAGGCCAACAAGCTGGCGGAGAAGCGGAAAGCCCACGATGAGGCGGTGAGGTCTGAGAAGAAGGCCAAGAAGGCAAGGCCGG
AGTGAGTGCCTGCGGCCCCTCACAGGGCTGAGGCCAGCCCCTAGCAGCTGGATGTGGCAGAGGCAGGCCAGAGGACCTAAGTGTGATGGA
CCAGAGTCACTTCTCCTCCTCCTTTCTCCAGCCAGCCCTGACCCCTCATGCTCTCTGGCTGGGCCAGTGGGCAGCCCTCGCTTCCCTTGG
ATGGAGCTGCCCTGCTGGTGCCTGGTCAGAGAAGAGGCCTCTGTGCCCAGCCTGATTCTCTGCTCCCAGGAGCCAGTGACATGAGGTGCA
GAGGCCCACCCAGCCCCCTACCTACTGCCCCCATTCATCCTGGCTTTCCACAGCCCCCTCCCACACAGTTGGACCCGTGATTCTCAGGGT

>81026_81026_3_SF3A1-PES1_SF3A1_chr22_30733015_ENST00000215793_PES1_chr22_30973116_ENST00000405677_length(amino acids)=737AA_BP=710
MAALSVAVMPAGPVQAVPPPPPVPTEPKQPTEEEASSKEDSAPSKPVVGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNEINNPKFN
FLNPNDPYHAYYRHKVSEFKEGKAQEPSAAIPKVMQQQQQTTQQQLPQKVQAQVIQETIVPKEPPPEFEFIADPPSISAFDLDVVKLTAQ
FVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTKILIPPKGLFSKLKKEAENPREVLDQVCYRVEWAKFQERERKKEEE
EKEKERVAYAQIDWHDFVVVETVDFQPNEQGNFPPPTTPEELGARILIQERYEKFGESEEVEMEVESDEEDDKQEKAEEPPSQLDQDTQV
QDMDEGSDDEEEGQKVPPPPETPMPPPLPPTPDQVIVRKDYDPKASKPLPPAPAPDEYLVSPITGEKIPASKMQEHMRIGLLDPRWLEQR
DRSIREKQSDDEVYAPGLDIESSLKQLAERRTDIFGVEETAIGKKIGEEEIQKPEEKVTWDGHSGSMARTQQAAQANITLQEQIEAIHKA
KGLVPEDDTKEKIGPSKPNEIPQQPPPPSSATNIPSSAPPITSVPRPPTMPPPVRTTVVSAVPVMPRPPMASVVRLPPGSVIAPMPPIIH
APRINVVPMPPSAPPIMAPRPPPMIVPTAFVPAPPVAPVPAPAPMPPVHPPPPMEDEPTSKKLKTEDSLMPEEEFLRRNKANKLAEKRKA

--------------------------------------------------------------
>81026_81026_4_SF3A1-PES1_SF3A1_chr22_30733015_ENST00000439242_PES1_chr22_30973116_ENST00000354694_length(transcript)=2548nt_BP=2043nt
ACCTTCGCGGCCGCAACTCGCTCGGCCGCCGCCATCTTGCGAGCTCGTCGTACTGACCGAGCGGGGAGGCTGTCTTGAGGCGGCACCGCT
CACCGACACCGAGGCGGACTGGCAGCCCTGAGCGTCGCAGTCATGCCGGCCGGACCCGTGCAGGCGGTGCCCCCGCCGCCGCCCGTGCCC
ACGGAGCCCAAACAGCCCACAGAAGAAGAAGCATCTTCAAAGGAGGATTCTGCACCTTCTAAGCCAGTTGTGGGGATTATTTACCCTCCT
CCAGAGGTCAGAAATATTGTTGACAAGACTGCCAGCTTTGTGGCCAGAAACGGGCCTGAATTTGAAGCTAGGATCCGACAGAACGAGATC
AACAACCCCAAGTTCAACTTTCTGAACCCCAATGACCCTTACCATGCCTACTACCGCCACAAGGTCAGCGAGTTCAAGGAAGGGAAGGCT
CAGTTTGTGGCCAGGAATGGGCGCCAGTTTCTGACCCAGCTGATGCAGAAAGAGCAGCGCAACTACCAGTTTGACTTTCTCCGCCCACAG
CACAGCCTCTTCAACTACTTCACGAAGCTAGTGGAACAGTACACCAAGATCTTGATTCCACCCAAAGGTTTATTTTCAAAGCTCAAGAAA
GAGGCTGAAAACCCCCGAGAAGTTTTGGATCAGGTGTGTTACCGAGTGGAATGGGCCAAATTCCAGGAACGTGAGAGGAAGAAGGAAGAA
GAGGAGAAGGAGAAGGAGCGGGTGGCCTATGCTCAGATCGACTGGCATGATTTTGTGGTGGTGGAAACAGTGGACTTCCAACCCAATGAG
CAAGGGAACTTCCCTCCCCCCACCACGCCAGAGGAGCTGGGGGCCCGAATCCTCATTCAGGAGCGCTATGAAAAGTTTGGGGAGAGTGAG
GAAGTTGAGATGGAGGTCGAGTCTGATGAGGAGGATGACAAACAGGAGAAGGCGGAGGAGCCTCCTTCCCAGCTGGACCAGGACACCCAA
GTACAAGATATGGATGAGGGTTCAGATGATGAAGAAGAAGGGCAGAAAGTGCCCCCACCCCCAGAGACACCCATGCCTCCACCTCTGCCC
CCAACTCCAGACCAAGTCATTGTCCGCAAGGATTATGATCCCAAAGCCTCCAAGCCCTTGCCTCCAGCCCCTGCTCCAGATGAGTATCTT
GTGTCCCCCATTACTGGGGAGAAGATCCCCGCCAGCAAAATGCAGGAACACATGCGCATTGGACTTCTTGACCCTCGCTGGCTGGAGCAG
CGGGATCGCTCCATCCGTGAGAAGCAGAGCGATGATGAGGTGTACGCACCAGGTCTGGATATTGAGAGCAGCTTGAAGCAGTTGGCTGAG
CGGCGTACTGACATCTTCGGTGTAGAGGAAACAGCCATTGGTAAGAAGATCGGTGAGGAGGAGATCCAGAAGCCAGAGGAAAAGGTGACC
TGGGATGGCCACTCAGGCAGCATGGCCCGGACCCAGCAGGCTGCCCAGGCCAACATCACCCTCCAGGAGCAGATTGAGGCCATTCACAAG
GCCAAAGGCCTGGTGCCAGAGGATGACACTAAAGAGAAGATTGGCCCCAGCAAGCCCAATGAAATCCCTCAACAGCCACCGCCACCATCT
TCAGCCACCAACATCCCCAGCTCGGCTCCACCCATCACTTCAGTGCCCCGACCACCCACAATGCCACCTCCAGTTCGTACTACAGTTGTC
TCCGCAGTACCCGTCATGCCCCGGCCCCCAATGGCATCTGTGGTCCGGCTGCCCCCAGGCTCAGTGATCGCCCCCATGCCGCCCATCATC
CACGCGCCCAGAATCAACGTGGTGCCCATGCCTCCCTCGGCCCCTCCTATTATGGCCCCCCGCCCACCCCCCATGATTGTGCCAACAGCC
TTTGTGCCTGCTCCACCTGTGGCACCTGTCCCAGCTCCAGCCCCAATGCCCCCTGTGCATCCCCCACCTCCCATGGAAGATGAGCCCACC
TCCAAAAAACTGAAGACAGAGGACAGCCTCATGCCAGAGGAGGAGTTCCTGCGCAGAAACAAGGCCAACAAGCTGGCGGAGAAGCGGAAA
GCCCACGATGAGGCGGTGAGGTCTGAGAAGAAGGCCAAGAAGGCAAGGCCGGAGTGAGTGCCTGCGGCCCCTCACAGGGCTGAGGCCAGC
CCCTAGCAGCTGGATGTGGCAGAGGCAGGCCAGAGGACCTAAGTGTGATGGACCAGAGTCACTTCTCCTCCTCCTTTCTCCAGCCAGCCC
TGACCCCTCATGCTCTCTGGCTGGGCCAGTGGGCAGCCCTCGCTTCCCTTGGATGGAGCTGCCCTGCTGGTGCCTGGTCAGAGAAGAGGC
CTCTGTGCCCAGCCTGATTCTCTGCTCCCAGGAGCCAGTGACATGAGGTGCAGAGGCCCACCCAGCCCCCTACCTACTGCCCCCATTCAT
CCTGGCTTTCCACAGCCCCCTCCCACACAGTTGGACCCGTGATTCTCAGGGTGCTGTGATGGGGTGAGGGTAGGGGGAGCATTTGTTATT

>81026_81026_4_SF3A1-PES1_SF3A1_chr22_30733015_ENST00000439242_PES1_chr22_30973116_ENST00000354694_length(amino acids)=672AA_BP=645
MAALSVAVMPAGPVQAVPPPPPVPTEPKQPTEEEASSKEDSAPSKPVVGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNEINNPKFN
FLNPNDPYHAYYRHKVSEFKEGKAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTKILIPPKGLFSKLKKEAENPR
EVLDQVCYRVEWAKFQERERKKEEEEKEKERVAYAQIDWHDFVVVETVDFQPNEQGNFPPPTTPEELGARILIQERYEKFGESEEVEMEV
ESDEEDDKQEKAEEPPSQLDQDTQVQDMDEGSDDEEEGQKVPPPPETPMPPPLPPTPDQVIVRKDYDPKASKPLPPAPAPDEYLVSPITG
EKIPASKMQEHMRIGLLDPRWLEQRDRSIREKQSDDEVYAPGLDIESSLKQLAERRTDIFGVEETAIGKKIGEEEIQKPEEKVTWDGHSG
SMARTQQAAQANITLQEQIEAIHKAKGLVPEDDTKEKIGPSKPNEIPQQPPPPSSATNIPSSAPPITSVPRPPTMPPPVRTTVVSAVPVM
PRPPMASVVRLPPGSVIAPMPPIIHAPRINVVPMPPSAPPIMAPRPPPMIVPTAFVPAPPVAPVPAPAPMPPVHPPPPMEDEPTSKKLKT

--------------------------------------------------------------
>81026_81026_5_SF3A1-PES1_SF3A1_chr22_30733015_ENST00000439242_PES1_chr22_30973116_ENST00000402284_length(transcript)=2508nt_BP=2043nt
ACCTTCGCGGCCGCAACTCGCTCGGCCGCCGCCATCTTGCGAGCTCGTCGTACTGACCGAGCGGGGAGGCTGTCTTGAGGCGGCACCGCT
CACCGACACCGAGGCGGACTGGCAGCCCTGAGCGTCGCAGTCATGCCGGCCGGACCCGTGCAGGCGGTGCCCCCGCCGCCGCCCGTGCCC
ACGGAGCCCAAACAGCCCACAGAAGAAGAAGCATCTTCAAAGGAGGATTCTGCACCTTCTAAGCCAGTTGTGGGGATTATTTACCCTCCT
CCAGAGGTCAGAAATATTGTTGACAAGACTGCCAGCTTTGTGGCCAGAAACGGGCCTGAATTTGAAGCTAGGATCCGACAGAACGAGATC
AACAACCCCAAGTTCAACTTTCTGAACCCCAATGACCCTTACCATGCCTACTACCGCCACAAGGTCAGCGAGTTCAAGGAAGGGAAGGCT
CAGTTTGTGGCCAGGAATGGGCGCCAGTTTCTGACCCAGCTGATGCAGAAAGAGCAGCGCAACTACCAGTTTGACTTTCTCCGCCCACAG
CACAGCCTCTTCAACTACTTCACGAAGCTAGTGGAACAGTACACCAAGATCTTGATTCCACCCAAAGGTTTATTTTCAAAGCTCAAGAAA
GAGGCTGAAAACCCCCGAGAAGTTTTGGATCAGGTGTGTTACCGAGTGGAATGGGCCAAATTCCAGGAACGTGAGAGGAAGAAGGAAGAA
GAGGAGAAGGAGAAGGAGCGGGTGGCCTATGCTCAGATCGACTGGCATGATTTTGTGGTGGTGGAAACAGTGGACTTCCAACCCAATGAG
CAAGGGAACTTCCCTCCCCCCACCACGCCAGAGGAGCTGGGGGCCCGAATCCTCATTCAGGAGCGCTATGAAAAGTTTGGGGAGAGTGAG
GAAGTTGAGATGGAGGTCGAGTCTGATGAGGAGGATGACAAACAGGAGAAGGCGGAGGAGCCTCCTTCCCAGCTGGACCAGGACACCCAA
GTACAAGATATGGATGAGGGTTCAGATGATGAAGAAGAAGGGCAGAAAGTGCCCCCACCCCCAGAGACACCCATGCCTCCACCTCTGCCC
CCAACTCCAGACCAAGTCATTGTCCGCAAGGATTATGATCCCAAAGCCTCCAAGCCCTTGCCTCCAGCCCCTGCTCCAGATGAGTATCTT
GTGTCCCCCATTACTGGGGAGAAGATCCCCGCCAGCAAAATGCAGGAACACATGCGCATTGGACTTCTTGACCCTCGCTGGCTGGAGCAG
CGGGATCGCTCCATCCGTGAGAAGCAGAGCGATGATGAGGTGTACGCACCAGGTCTGGATATTGAGAGCAGCTTGAAGCAGTTGGCTGAG
CGGCGTACTGACATCTTCGGTGTAGAGGAAACAGCCATTGGTAAGAAGATCGGTGAGGAGGAGATCCAGAAGCCAGAGGAAAAGGTGACC
TGGGATGGCCACTCAGGCAGCATGGCCCGGACCCAGCAGGCTGCCCAGGCCAACATCACCCTCCAGGAGCAGATTGAGGCCATTCACAAG
GCCAAAGGCCTGGTGCCAGAGGATGACACTAAAGAGAAGATTGGCCCCAGCAAGCCCAATGAAATCCCTCAACAGCCACCGCCACCATCT
TCAGCCACCAACATCCCCAGCTCGGCTCCACCCATCACTTCAGTGCCCCGACCACCCACAATGCCACCTCCAGTTCGTACTACAGTTGTC
TCCGCAGTACCCGTCATGCCCCGGCCCCCAATGGCATCTGTGGTCCGGCTGCCCCCAGGCTCAGTGATCGCCCCCATGCCGCCCATCATC
CACGCGCCCAGAATCAACGTGGTGCCCATGCCTCCCTCGGCCCCTCCTATTATGGCCCCCCGCCCACCCCCCATGATTGTGCCAACAGCC
TTTGTGCCTGCTCCACCTGTGGCACCTGTCCCAGCTCCAGCCCCAATGCCCCCTGTGCATCCCCCACCTCCCATGGAAGATGAGCCCACC
TCCAAAAAACTGAAGACAGAGGACAGCCTCATGCCAGAGGAGGAGTTCCTGCGCAGAAACAAGGCCAACAAGCTGGCGGAGAAGCGGAAA
GCCCACGATGAGGCGGTGAGGTCTGAGAAGAAGGCCAAGAAGGCAAGGCCGGAGTGAGTGCCTGCGGCCCCTCACAGGGCTGAGGCCAGC
CCCTAGCAGCTGGATGTGGCAGAGGCAGGCCAGAGGACCTAAGTGTGATGGACCAGAGTCACTTCTCCTCCTCCTTTCTCCAGCCAGCCC
TGACCCCTCATGCTCTCTGGCTGGGCCAGTGGGCAGCCCTCGCTTCCCTTGGATGGAGCTGCCCTGCTGGTGCCTGGTCAGAGAAGAGGC
CTCTGTGCCCAGCCTGATTCTCTGCTCCCAGGAGCCAGTGACATGAGGTGCAGAGGCCCACCCAGCCCCCTACCTACTGCCCCCATTCAT

>81026_81026_5_SF3A1-PES1_SF3A1_chr22_30733015_ENST00000439242_PES1_chr22_30973116_ENST00000402284_length(amino acids)=672AA_BP=645
MAALSVAVMPAGPVQAVPPPPPVPTEPKQPTEEEASSKEDSAPSKPVVGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNEINNPKFN
FLNPNDPYHAYYRHKVSEFKEGKAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTKILIPPKGLFSKLKKEAENPR
EVLDQVCYRVEWAKFQERERKKEEEEKEKERVAYAQIDWHDFVVVETVDFQPNEQGNFPPPTTPEELGARILIQERYEKFGESEEVEMEV
ESDEEDDKQEKAEEPPSQLDQDTQVQDMDEGSDDEEEGQKVPPPPETPMPPPLPPTPDQVIVRKDYDPKASKPLPPAPAPDEYLVSPITG
EKIPASKMQEHMRIGLLDPRWLEQRDRSIREKQSDDEVYAPGLDIESSLKQLAERRTDIFGVEETAIGKKIGEEEIQKPEEKVTWDGHSG
SMARTQQAAQANITLQEQIEAIHKAKGLVPEDDTKEKIGPSKPNEIPQQPPPPSSATNIPSSAPPITSVPRPPTMPPPVRTTVVSAVPVM
PRPPMASVVRLPPGSVIAPMPPIIHAPRINVVPMPPSAPPIMAPRPPPMIVPTAFVPAPPVAPVPAPAPMPPVHPPPPMEDEPTSKKLKT

--------------------------------------------------------------
>81026_81026_6_SF3A1-PES1_SF3A1_chr22_30733015_ENST00000439242_PES1_chr22_30973116_ENST00000405677_length(transcript)=2541nt_BP=2043nt
ACCTTCGCGGCCGCAACTCGCTCGGCCGCCGCCATCTTGCGAGCTCGTCGTACTGACCGAGCGGGGAGGCTGTCTTGAGGCGGCACCGCT
CACCGACACCGAGGCGGACTGGCAGCCCTGAGCGTCGCAGTCATGCCGGCCGGACCCGTGCAGGCGGTGCCCCCGCCGCCGCCCGTGCCC
ACGGAGCCCAAACAGCCCACAGAAGAAGAAGCATCTTCAAAGGAGGATTCTGCACCTTCTAAGCCAGTTGTGGGGATTATTTACCCTCCT
CCAGAGGTCAGAAATATTGTTGACAAGACTGCCAGCTTTGTGGCCAGAAACGGGCCTGAATTTGAAGCTAGGATCCGACAGAACGAGATC
AACAACCCCAAGTTCAACTTTCTGAACCCCAATGACCCTTACCATGCCTACTACCGCCACAAGGTCAGCGAGTTCAAGGAAGGGAAGGCT
CAGTTTGTGGCCAGGAATGGGCGCCAGTTTCTGACCCAGCTGATGCAGAAAGAGCAGCGCAACTACCAGTTTGACTTTCTCCGCCCACAG
CACAGCCTCTTCAACTACTTCACGAAGCTAGTGGAACAGTACACCAAGATCTTGATTCCACCCAAAGGTTTATTTTCAAAGCTCAAGAAA
GAGGCTGAAAACCCCCGAGAAGTTTTGGATCAGGTGTGTTACCGAGTGGAATGGGCCAAATTCCAGGAACGTGAGAGGAAGAAGGAAGAA
GAGGAGAAGGAGAAGGAGCGGGTGGCCTATGCTCAGATCGACTGGCATGATTTTGTGGTGGTGGAAACAGTGGACTTCCAACCCAATGAG
CAAGGGAACTTCCCTCCCCCCACCACGCCAGAGGAGCTGGGGGCCCGAATCCTCATTCAGGAGCGCTATGAAAAGTTTGGGGAGAGTGAG
GAAGTTGAGATGGAGGTCGAGTCTGATGAGGAGGATGACAAACAGGAGAAGGCGGAGGAGCCTCCTTCCCAGCTGGACCAGGACACCCAA
GTACAAGATATGGATGAGGGTTCAGATGATGAAGAAGAAGGGCAGAAAGTGCCCCCACCCCCAGAGACACCCATGCCTCCACCTCTGCCC
CCAACTCCAGACCAAGTCATTGTCCGCAAGGATTATGATCCCAAAGCCTCCAAGCCCTTGCCTCCAGCCCCTGCTCCAGATGAGTATCTT
GTGTCCCCCATTACTGGGGAGAAGATCCCCGCCAGCAAAATGCAGGAACACATGCGCATTGGACTTCTTGACCCTCGCTGGCTGGAGCAG
CGGGATCGCTCCATCCGTGAGAAGCAGAGCGATGATGAGGTGTACGCACCAGGTCTGGATATTGAGAGCAGCTTGAAGCAGTTGGCTGAG
CGGCGTACTGACATCTTCGGTGTAGAGGAAACAGCCATTGGTAAGAAGATCGGTGAGGAGGAGATCCAGAAGCCAGAGGAAAAGGTGACC
TGGGATGGCCACTCAGGCAGCATGGCCCGGACCCAGCAGGCTGCCCAGGCCAACATCACCCTCCAGGAGCAGATTGAGGCCATTCACAAG
GCCAAAGGCCTGGTGCCAGAGGATGACACTAAAGAGAAGATTGGCCCCAGCAAGCCCAATGAAATCCCTCAACAGCCACCGCCACCATCT
TCAGCCACCAACATCCCCAGCTCGGCTCCACCCATCACTTCAGTGCCCCGACCACCCACAATGCCACCTCCAGTTCGTACTACAGTTGTC
TCCGCAGTACCCGTCATGCCCCGGCCCCCAATGGCATCTGTGGTCCGGCTGCCCCCAGGCTCAGTGATCGCCCCCATGCCGCCCATCATC
CACGCGCCCAGAATCAACGTGGTGCCCATGCCTCCCTCGGCCCCTCCTATTATGGCCCCCCGCCCACCCCCCATGATTGTGCCAACAGCC
TTTGTGCCTGCTCCACCTGTGGCACCTGTCCCAGCTCCAGCCCCAATGCCCCCTGTGCATCCCCCACCTCCCATGGAAGATGAGCCCACC
TCCAAAAAACTGAAGACAGAGGACAGCCTCATGCCAGAGGAGGAGTTCCTGCGCAGAAACAAGGCCAACAAGCTGGCGGAGAAGCGGAAA
GCCCACGATGAGGCGGTGAGGTCTGAGAAGAAGGCCAAGAAGGCAAGGCCGGAGTGAGTGCCTGCGGCCCCTCACAGGGCTGAGGCCAGC
CCCTAGCAGCTGGATGTGGCAGAGGCAGGCCAGAGGACCTAAGTGTGATGGACCAGAGTCACTTCTCCTCCTCCTTTCTCCAGCCAGCCC
TGACCCCTCATGCTCTCTGGCTGGGCCAGTGGGCAGCCCTCGCTTCCCTTGGATGGAGCTGCCCTGCTGGTGCCTGGTCAGAGAAGAGGC
CTCTGTGCCCAGCCTGATTCTCTGCTCCCAGGAGCCAGTGACATGAGGTGCAGAGGCCCACCCAGCCCCCTACCTACTGCCCCCATTCAT
CCTGGCTTTCCACAGCCCCCTCCCACACAGTTGGACCCGTGATTCTCAGGGTGCTGTGATGGGGTGAGGGTAGGGGGAGCATTTGTTATT

>81026_81026_6_SF3A1-PES1_SF3A1_chr22_30733015_ENST00000439242_PES1_chr22_30973116_ENST00000405677_length(amino acids)=672AA_BP=645
MAALSVAVMPAGPVQAVPPPPPVPTEPKQPTEEEASSKEDSAPSKPVVGIIYPPPEVRNIVDKTASFVARNGPEFEARIRQNEINNPKFN
FLNPNDPYHAYYRHKVSEFKEGKAQFVARNGRQFLTQLMQKEQRNYQFDFLRPQHSLFNYFTKLVEQYTKILIPPKGLFSKLKKEAENPR
EVLDQVCYRVEWAKFQERERKKEEEEKEKERVAYAQIDWHDFVVVETVDFQPNEQGNFPPPTTPEELGARILIQERYEKFGESEEVEMEV
ESDEEDDKQEKAEEPPSQLDQDTQVQDMDEGSDDEEEGQKVPPPPETPMPPPLPPTPDQVIVRKDYDPKASKPLPPAPAPDEYLVSPITG
EKIPASKMQEHMRIGLLDPRWLEQRDRSIREKQSDDEVYAPGLDIESSLKQLAERRTDIFGVEETAIGKKIGEEEIQKPEEKVTWDGHSG
SMARTQQAAQANITLQEQIEAIHKAKGLVPEDDTKEKIGPSKPNEIPQQPPPPSSATNIPSSAPPITSVPRPPTMPPPVRTTVVSAVPVM
PRPPMASVVRLPPGSVIAPMPPIIHAPRINVVPMPPSAPPIMAPRPPPMIVPTAFVPAPPVAPVPAPAPMPPVHPPPPMEDEPTSKKLKT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SF3A1-PES1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SF3A1-PES1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SF3A1-PES1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource