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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:SF3B3-CTCF (FusionGDB2 ID:81068) |
Fusion Gene Summary for SF3B3-CTCF |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SF3B3-CTCF | Fusion gene ID: 81068 | Hgene | Tgene | Gene symbol | SF3B3 | CTCF | Gene ID | 23450 | 10664 |
| Gene name | splicing factor 3b subunit 3 | CCCTC-binding factor | |
| Synonyms | RSE1|SAP130|SF3b130|STAF130 | CFAP108|FAP108|MRD21 | |
| Cytomap | 16q22.1 | 16q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | splicing factor 3B subunit 3SAP 130pre-mRNA splicing factor SF3b, 130 kDa subunitspliceosome-associated protein 130 | transcriptional repressor CTCF11 zinc finger transcriptional repressor11-zinc finger proteinCCCTC-binding factor (zinc finger protein)CTCFL paralog | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | Q8NI51 | |
| Ensembl transtripts involved in fusion gene | ENST00000302516, | ENST00000264010, ENST00000401394, | |
| Fusion gene scores | * DoF score | 13 X 15 X 9=1755 | 9 X 9 X 4=324 |
| # samples | 18 | 8 | |
| ** MAII score | log2(18/1755*10)=-3.28540221886225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/324*10)=-2.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SF3B3 [Title/Abstract] AND CTCF [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | SF3B3(70578436)-CTCF(67660458), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | SF3B3-CTCF seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. SF3B3-CTCF seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. SF3B3-CTCF seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. SF3B3-CTCF seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF. SF3B3-CTCF seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. SF3B3-CTCF seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF. SF3B3-CTCF seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SF3B3 | GO:0000398 | mRNA splicing, via spliceosome | 28781166|29360106 |
| Hgene | SF3B3 | GO:0042177 | negative regulation of protein catabolic process | 23951410 |
| Tgene | CTCF | GO:0000122 | negative regulation of transcription by RNA polymerase II | 8649389 |
| Tgene | CTCF | GO:0016584 | nucleosome positioning | 18654629 |
| Tgene | CTCF | GO:0045892 | negative regulation of transcription, DNA-templated | 8649389|18413740 |
| Tgene | CTCF | GO:0045893 | positive regulation of transcription, DNA-templated | 9407128 |
| Fusion gene breakpoints across SF3B3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across CTCF (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | OV | TCGA-24-2289-01A | SF3B3 | chr16 | 70578436 | + | CTCF | chr16 | 67660458 | + |
| ChimerDB4 | OV | TCGA-24-2289-01A | SF3B3 | chr16 | 70578436 | + | CTCF | chr16 | 67662273 | + |
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Fusion Gene ORF analysis for SF3B3-CTCF |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000302516 | ENST00000264010 | SF3B3 | chr16 | 70578436 | + | CTCF | chr16 | 67660458 | + |
| Frame-shift | ENST00000302516 | ENST00000401394 | SF3B3 | chr16 | 70578436 | + | CTCF | chr16 | 67660458 | + |
| In-frame | ENST00000302516 | ENST00000264010 | SF3B3 | chr16 | 70578436 | + | CTCF | chr16 | 67662273 | + |
| In-frame | ENST00000302516 | ENST00000401394 | SF3B3 | chr16 | 70578436 | + | CTCF | chr16 | 67662273 | + |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000302516 | SF3B3 | chr16 | 70578436 | + | ENST00000264010 | CTCF | chr16 | 67662273 | + | 3517 | 1540 | 109 | 2205 | 698 |
| ENST00000302516 | SF3B3 | chr16 | 70578436 | + | ENST00000401394 | CTCF | chr16 | 67662273 | + | 3517 | 1540 | 109 | 2205 | 698 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000302516 | ENST00000264010 | SF3B3 | chr16 | 70578436 | + | CTCF | chr16 | 67662273 | + | 0.000765722 | 0.9992343 |
| ENST00000302516 | ENST00000401394 | SF3B3 | chr16 | 70578436 | + | CTCF | chr16 | 67662273 | + | 0.000765722 | 0.9992343 |
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Fusion Genomic Features for SF3B3-CTCF |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| SF3B3 | chr16 | 70578436 | + | CTCF | chr16 | 67660457 | + | 3.86E-09 | 1 |
| SF3B3 | chr16 | 70578436 | + | CTCF | chr16 | 67662272 | + | 4.64E-10 | 1 |
| SF3B3 | chr16 | 70578436 | + | CTCF | chr16 | 67660457 | + | 3.86E-09 | 1 |
| SF3B3 | chr16 | 70578436 | + | CTCF | chr16 | 67662272 | + | 4.64E-10 | 1 |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for SF3B3-CTCF |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:70578436/chr16:67660458) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | CTCF |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters. {ECO:0000250, ECO:0000269|PubMed:12011441, ECO:0000269|PubMed:18413740, ECO:0000269|PubMed:18765639}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000264010 | 7 | 12 | 523_546 | 506 | 728.0 | Zinc finger | C2H2-type 10 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000264010 | 7 | 12 | 555_577 | 506 | 728.0 | Zinc finger | C2H2-type 11%3B atypical | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000401394 | 5 | 10 | 266_288 | 178 | 400.0 | Zinc finger | C2H2-type 1 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000401394 | 5 | 10 | 294_316 | 178 | 400.0 | Zinc finger | C2H2-type 2 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000401394 | 5 | 10 | 322_345 | 178 | 400.0 | Zinc finger | C2H2-type 3 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000401394 | 5 | 10 | 351_373 | 178 | 400.0 | Zinc finger | C2H2-type 4 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000401394 | 5 | 10 | 379_401 | 178 | 400.0 | Zinc finger | C2H2-type 5 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000401394 | 5 | 10 | 407_430 | 178 | 400.0 | Zinc finger | C2H2-type 6 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000401394 | 5 | 10 | 437_460 | 178 | 400.0 | Zinc finger | C2H2-type 7 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000401394 | 5 | 10 | 467_489 | 178 | 400.0 | Zinc finger | C2H2-type 8 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000401394 | 5 | 10 | 495_517 | 178 | 400.0 | Zinc finger | C2H2-type 9 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000401394 | 5 | 10 | 523_546 | 178 | 400.0 | Zinc finger | C2H2-type 10 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000401394 | 5 | 10 | 555_577 | 178 | 400.0 | Zinc finger | C2H2-type 11%3B atypical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000264010 | 7 | 12 | 266_288 | 506 | 728.0 | Zinc finger | C2H2-type 1 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000264010 | 7 | 12 | 294_316 | 506 | 728.0 | Zinc finger | C2H2-type 2 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000264010 | 7 | 12 | 322_345 | 506 | 728.0 | Zinc finger | C2H2-type 3 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000264010 | 7 | 12 | 351_373 | 506 | 728.0 | Zinc finger | C2H2-type 4 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000264010 | 7 | 12 | 379_401 | 506 | 728.0 | Zinc finger | C2H2-type 5 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000264010 | 7 | 12 | 407_430 | 506 | 728.0 | Zinc finger | C2H2-type 6 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000264010 | 7 | 12 | 437_460 | 506 | 728.0 | Zinc finger | C2H2-type 7 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000264010 | 7 | 12 | 467_489 | 506 | 728.0 | Zinc finger | C2H2-type 8 | |
| Tgene | CTCF | chr16:70578436 | chr16:67662273 | ENST00000264010 | 7 | 12 | 495_517 | 506 | 728.0 | Zinc finger | C2H2-type 9 |
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Fusion Gene Sequence for SF3B3-CTCF |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >81068_81068_1_SF3B3-CTCF_SF3B3_chr16_70578436_ENST00000302516_CTCF_chr16_67662273_ENST00000264010_length(transcript)=3517nt_BP=1540nt GCCTTTTTCCGCCGCGCGCCACCAGAATGTCCCTGTCTTGAGGTCTAATGGCGGACGCCAGTATGTTGGAGTTGGTGGTGGCTTAAGTTT TGAAGGGAGGTAGCATCCGTTGGATATCCACACCATCCTTCTCGCTGCAGGCTTTCTTGGACTCCGTACTGTTGGTGTAACCAAGGCCTG GAGGTCTGGGTGGCTCAGGTTTCCTGCAGCCATGTTTCTGTACAACTTAACCTTGCAGAGAGCCACTGGCATCAGCTTTGCCATTCATGG AAACTTTTCTGGAACCAAACAACAAGAAATTGTTGTTTCCCGTGGGAAGATCTTGGAGCTGCTTCGCCCAGACCCCAACACTGGCAAAGT ACATACCCTACTCACTGTGGAAGTATTCGGTGTTATCCGGTCACTCATGGCCTTTAGGCTGACAGGTGGCACCAAAGACTACATTGTAGT TGGCAGTGACTCTGGTCGAATTGTTATTTTGGAATACCAGCCATCTAAGAATATGTTTGAGAAGATTCACCAAGAAACCTTTGGCAAGAG TGGATGCCGTCGCATCGTTCCTGGCCAGTTCTTAGCTGTGGATCCCAAAGGGCGAGCCGTTATGATTAGTGCCATTGAGAAACAGAAATT GGTGTATATTTTGAACAGAGATGCTGCAGCCCGACTTACCATTTCATCTCCCCTGGAAGCCCACAAAGCAAACACTTTAGTGTATCATGT AGTTGGAGTAGATGTCGGATTTGAAAATCCAATGTTTGCTTGTCTGGAAATGGATTATGAGGAAGCAGACAATGATCCAACAGGGGAAGC AGCAGCTAATACCCAGCAGACACTTACTTTCTATGAGCTAGACCTTGGTTTAAATCATGTGGTCCGAAAATACAGTGAACCTTTGGAGGA ACACGGCAACTTCCTTATTACAGTTCCAGGAGGGTCAGATGGTCCAAGTGGAGTACTGATCTGCTCTGAAAACTATATTACTTACAAGAA CTTTGGTGACCAGCCAGATATCCGCTGTCCAATTCCCAGGAGGCGGAATGACCTGGATGACCCTGAAAGAGGAATGATTTTTGTCTGCTC TGCAACCCATAAAACCAAATCGATGTTCTTCTTTTTGGCTCAAACTGAGCAGGGAGATATCTTTAAGATCACTTTGGAGACAGATGAAGA TATGGTTACTGAGATCCGGCTCAAATATTTTGATACTGTACCCGTTGCTGCTGCCATGTGTGTGCTTAAAACAGGGTTCCTTTTTGTAGC ATCAGAATTTGGAAACCATTACTTATATCAAATTGCACATCTTGGAGATGATGATGAAGAACCTGAGTTTTCATCAGCCATGCCTCTGGA AGAAGGAGACACATTCTTTTTTCAGCCAAGACCACTTAAAAACCTTGTGCTGGTTGATGAGTTGGACAGCCTCTCTCCCATTCTGTTTTG CCAGATAGCTGATCTGGCCAATGAAGATACTCCACAGTTGTATGTGGCCTGTGGTAGGGGACCCCGATCATCTCTGAGAGTCCTAAGACA TGGACTTGAGGAGAGGCACATGATCATGCACAAGCGCACCCACACCGGGGAGAAGCCTTACGCCTGCAGCCACTGCGATAAGACCTTCCG CCAGAAGCAGCTTCTCGACATGCACTTCAAGCGCTATCACGACCCCAACTTCGTCCCTGCGGCTTTTGTCTGTTCTAAGTGTGGGAAAAC ATTTACACGTCGGAATACCATGGCAAGACATGCTGATAATTGTGCTGGCCCAGATGGCGTAGAGGGGGAAAATGGAGGAGAAACGAAGAA GAGTAAACGTGGAAGAAAAAGAAAGATGCGCTCTAAGAAAGAAGATTCCTCTGACAGTGAAAATGCTGAACCAGATCTGGACGACAATGA GGATGAGGAGGAGCCTGCCGTAGAAATTGAACCTGAGCCAGAGCCTCAGCCTGTGACCCCAGCCCCACCACCCGCCAAGAAGCGGAGAGG ACGACCCCCTGGCAGAACCAACCAGCCCAAACAGAACCAGCCAACAGCTATCATTCAGGTTGAAGACCAGAATACAGGTGCAATTGAGAA CATTATAGTTGAAGTAAAAAAAGAGCCAGATGCTGAGCCCGCAGAGGGAGAGGAAGAGGAGGCCCAGCCAGCTGCCACAGATGCCCCCAA CGGAGACCTCACGCCCGAGATGATCCTCAGCATGATGGACCGGTGATGGCGGAGCCTTGTGCGTCGCCAGGACTTCTCTGGGCTGTGTTT AAACGGCCCGCATCTTAATTTTTCTCCCTTCTTTCTTTTTTTGGCTTTGGGAAAAGCATCATTTTACCAAACATACCGAGAACGAAAACT TCAAGGATGATGTTAGAAAAAAATGTGATTTAACTAGAACTTGCTGTCTGATGTTAGCAAATCATGGAATGTTCTGAGTCCCTGAGGGTT TACTGTGAAGTGCTGAGGACAGTGTTGACAACTAACTCGTTTTCCTAGATGGAAACGGAGACATTGACCCCTCCCTCCATGTGGTAAACC ACTCCAGAATGGCCACCAGGCTTCCCAGAGTTCTATGGTCTTCTTCCCAAGAGAGTTTTTAATTGTAAATGCATACTTGGGAAGGACTTA GAGTTTTAAACTGTTTTTTGCTTTTGCTTTTCCCTGACTCCCTTTGCTTGGAGTCAGCTGCACACCAGTAGTATGGCATGCTACGATCAG GTTCTGTCCTGAAAGCTTTGCCTCTTTCTTGGCAAAGTTTCTGGTATGGTCAAGCTTGTAAATAACTTTTTTTACATTTTAATCTTTTCC ATTAATTAAGAGGTTGAAAAGAAGTGCAGTGTAAGAAAACCCAGCATTTTAATTACTTGCAAATTAAGTTACCACAGACTCTGTAGTGTG TAAATGTTGACAAGGAATTGGATCACAATCATGTAGCAGAATGGCACCCAGACCACTGCCCACCAGTGACGGACATGCACGTGGCAGATC ATGATTTCCAGCCCACGGAGCCAGCATTTGAACCTTGTATAATTAACTTTCAGTTATGATTTCCCATCGACATTTTCTTTGCCCTGTTTG TAGCTGATTGTTGTGTTTTATAAATCTTCTGTTAAGGCAGAAGGGTGATTATGAGTGGTTCACAGCAGCCCTTATAAGCTGGGCCAGAAA ATTTCACTAGGTCAGTAATTTAAACCTTGGATCTTCAAAAAATAAAATAATGTGAAGCAAAACCAACTAAAAAGTGATTCTTGCACATGA ACTGTCACATGTTTAAAAATGTGTTTTTTAGAGAGCCTCAGTCTTACTGATTTCAAACACTTTTTTCTTCTGTGTATTGCTTTTAAGAGA GCCATCAGTTAGCTATCAGACTCTAGGTTGATGCATTTTGTACTTAGCTGTACTGTGTGATATTTTTCATTATTTTAGGACGCCAACATG AGACCTGTAATAAAATATGTAATGGGGTTGAAAGCTGGGGAGGAGGATCTACTGCTGTACAGCTAATAAATCATAACGGATTAACAAGTG >81068_81068_1_SF3B3-CTCF_SF3B3_chr16_70578436_ENST00000302516_CTCF_chr16_67662273_ENST00000264010_length(amino acids)=698AA_BP=477 MDIHTILLAAGFLGLRTVGVTKAWRSGWLRFPAAMFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTV EVFGVIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVYILNR DAAARLTISSPLEAHKANTLVYHVVGVDVGFENPMFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLI TVPGGSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIR LKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLA NEDTPQLYVACGRGPRSSLRVLRHGLEERHMIMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTRRNT MARHADNCAGPDGVEGENGGETKKSKRGRKRKMRSKKEDSSDSENAEPDLDDNEDEEEPAVEIEPEPEPQPVTPAPPPAKKRRGRPPGRT -------------------------------------------------------------- >81068_81068_2_SF3B3-CTCF_SF3B3_chr16_70578436_ENST00000302516_CTCF_chr16_67662273_ENST00000401394_length(transcript)=3517nt_BP=1540nt GCCTTTTTCCGCCGCGCGCCACCAGAATGTCCCTGTCTTGAGGTCTAATGGCGGACGCCAGTATGTTGGAGTTGGTGGTGGCTTAAGTTT TGAAGGGAGGTAGCATCCGTTGGATATCCACACCATCCTTCTCGCTGCAGGCTTTCTTGGACTCCGTACTGTTGGTGTAACCAAGGCCTG GAGGTCTGGGTGGCTCAGGTTTCCTGCAGCCATGTTTCTGTACAACTTAACCTTGCAGAGAGCCACTGGCATCAGCTTTGCCATTCATGG AAACTTTTCTGGAACCAAACAACAAGAAATTGTTGTTTCCCGTGGGAAGATCTTGGAGCTGCTTCGCCCAGACCCCAACACTGGCAAAGT ACATACCCTACTCACTGTGGAAGTATTCGGTGTTATCCGGTCACTCATGGCCTTTAGGCTGACAGGTGGCACCAAAGACTACATTGTAGT TGGCAGTGACTCTGGTCGAATTGTTATTTTGGAATACCAGCCATCTAAGAATATGTTTGAGAAGATTCACCAAGAAACCTTTGGCAAGAG TGGATGCCGTCGCATCGTTCCTGGCCAGTTCTTAGCTGTGGATCCCAAAGGGCGAGCCGTTATGATTAGTGCCATTGAGAAACAGAAATT GGTGTATATTTTGAACAGAGATGCTGCAGCCCGACTTACCATTTCATCTCCCCTGGAAGCCCACAAAGCAAACACTTTAGTGTATCATGT AGTTGGAGTAGATGTCGGATTTGAAAATCCAATGTTTGCTTGTCTGGAAATGGATTATGAGGAAGCAGACAATGATCCAACAGGGGAAGC AGCAGCTAATACCCAGCAGACACTTACTTTCTATGAGCTAGACCTTGGTTTAAATCATGTGGTCCGAAAATACAGTGAACCTTTGGAGGA ACACGGCAACTTCCTTATTACAGTTCCAGGAGGGTCAGATGGTCCAAGTGGAGTACTGATCTGCTCTGAAAACTATATTACTTACAAGAA CTTTGGTGACCAGCCAGATATCCGCTGTCCAATTCCCAGGAGGCGGAATGACCTGGATGACCCTGAAAGAGGAATGATTTTTGTCTGCTC TGCAACCCATAAAACCAAATCGATGTTCTTCTTTTTGGCTCAAACTGAGCAGGGAGATATCTTTAAGATCACTTTGGAGACAGATGAAGA TATGGTTACTGAGATCCGGCTCAAATATTTTGATACTGTACCCGTTGCTGCTGCCATGTGTGTGCTTAAAACAGGGTTCCTTTTTGTAGC ATCAGAATTTGGAAACCATTACTTATATCAAATTGCACATCTTGGAGATGATGATGAAGAACCTGAGTTTTCATCAGCCATGCCTCTGGA AGAAGGAGACACATTCTTTTTTCAGCCAAGACCACTTAAAAACCTTGTGCTGGTTGATGAGTTGGACAGCCTCTCTCCCATTCTGTTTTG CCAGATAGCTGATCTGGCCAATGAAGATACTCCACAGTTGTATGTGGCCTGTGGTAGGGGACCCCGATCATCTCTGAGAGTCCTAAGACA TGGACTTGAGGAGAGGCACATGATCATGCACAAGCGCACCCACACCGGGGAGAAGCCTTACGCCTGCAGCCACTGCGATAAGACCTTCCG CCAGAAGCAGCTTCTCGACATGCACTTCAAGCGCTATCACGACCCCAACTTCGTCCCTGCGGCTTTTGTCTGTTCTAAGTGTGGGAAAAC ATTTACACGTCGGAATACCATGGCAAGACATGCTGATAATTGTGCTGGCCCAGATGGCGTAGAGGGGGAAAATGGAGGAGAAACGAAGAA GAGTAAACGTGGAAGAAAAAGAAAGATGCGCTCTAAGAAAGAAGATTCCTCTGACAGTGAAAATGCTGAACCAGATCTGGACGACAATGA GGATGAGGAGGAGCCTGCCGTAGAAATTGAACCTGAGCCAGAGCCTCAGCCTGTGACCCCAGCCCCACCACCCGCCAAGAAGCGGAGAGG ACGACCCCCTGGCAGAACCAACCAGCCCAAACAGAACCAGCCAACAGCTATCATTCAGGTTGAAGACCAGAATACAGGTGCAATTGAGAA CATTATAGTTGAAGTAAAAAAAGAGCCAGATGCTGAGCCCGCAGAGGGAGAGGAAGAGGAGGCCCAGCCAGCTGCCACAGATGCCCCCAA CGGAGACCTCACGCCCGAGATGATCCTCAGCATGATGGACCGGTGATGGCGGAGCCTTGTGCGTCGCCAGGACTTCTCTGGGCTGTGTTT AAACGGCCCGCATCTTAATTTTTCTCCCTTCTTTCTTTTTTTGGCTTTGGGAAAAGCATCATTTTACCAAACATACCGAGAACGAAAACT TCAAGGATGATGTTAGAAAAAAATGTGATTTAACTAGAACTTGCTGTCTGATGTTAGCAAATCATGGAATGTTCTGAGTCCCTGAGGGTT TACTGTGAAGTGCTGAGGACAGTGTTGACAACTAACTCGTTTTCCTAGATGGAAACGGAGACATTGACCCCTCCCTCCATGTGGTAAACC ACTCCAGAATGGCCACCAGGCTTCCCAGAGTTCTATGGTCTTCTTCCCAAGAGAGTTTTTAATTGTAAATGCATACTTGGGAAGGACTTA GAGTTTTAAACTGTTTTTTGCTTTTGCTTTTCCCTGACTCCCTTTGCTTGGAGTCAGCTGCACACCAGTAGTATGGCATGCTACGATCAG GTTCTGTCCTGAAAGCTTTGCCTCTTTCTTGGCAAAGTTTCTGGTATGGTCAAGCTTGTAAATAACTTTTTTTACATTTTAATCTTTTCC ATTAATTAAGAGGTTGAAAAGAAGTGCAGTGTAAGAAAACCCAGCATTTTAATTACTTGCAAATTAAGTTACCACAGACTCTGTAGTGTG TAAATGTTGACAAGGAATTGGATCACAATCATGTAGCAGAATGGCACCCAGACCACTGCCCACCAGTGACGGACATGCACGTGGCAGATC ATGATTTCCAGCCCACGGAGCCAGCATTTGAACCTTGTATAATTAACTTTCAGTTATGATTTCCCATCGACATTTTCTTTGCCCTGTTTG TAGCTGATTGTTGTGTTTTATAAATCTTCTGTTAAGGCAGAAGGGTGATTATGAGTGGTTCACAGCAGCCCTTATAAGCTGGGCCAGAAA ATTTCACTAGGTCAGTAATTTAAACCTTGGATCTTCAAAAAATAAAATAATGTGAAGCAAAACCAACTAAAAAGTGATTCTTGCACATGA ACTGTCACATGTTTAAAAATGTGTTTTTTAGAGAGCCTCAGTCTTACTGATTTCAAACACTTTTTTCTTCTGTGTATTGCTTTTAAGAGA GCCATCAGTTAGCTATCAGACTCTAGGTTGATGCATTTTGTACTTAGCTGTACTGTGTGATATTTTTCATTATTTTAGGACGCCAACATG AGACCTGTAATAAAATATGTAATGGGGTTGAAAGCTGGGGAGGAGGATCTACTGCTGTACAGCTAATAAATCATAACGGATTAACAAGTG >81068_81068_2_SF3B3-CTCF_SF3B3_chr16_70578436_ENST00000302516_CTCF_chr16_67662273_ENST00000401394_length(amino acids)=698AA_BP=477 MDIHTILLAAGFLGLRTVGVTKAWRSGWLRFPAAMFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTV EVFGVIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVYILNR DAAARLTISSPLEAHKANTLVYHVVGVDVGFENPMFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLI TVPGGSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIR LKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLA NEDTPQLYVACGRGPRSSLRVLRHGLEERHMIMHKRTHTGEKPYACSHCDKTFRQKQLLDMHFKRYHDPNFVPAAFVCSKCGKTFTRRNT MARHADNCAGPDGVEGENGGETKKSKRGRKRKMRSKKEDSSDSENAEPDLDDNEDEEEPAVEIEPEPEPQPVTPAPPPAKKRRGRPPGRT -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for SF3B3-CTCF |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Hgene | SF3B3 | chr16:70578436 | chr16:67662273 | ENST00000302516 | + | 10 | 26 | 105_119 | 443.0 | 1218.0 | PHF5A%2C SF3B1 and SF3B5 |
| Hgene | SF3B3 | chr16:70578436 | chr16:67662273 | ENST00000302516 | + | 10 | 26 | 145_168 | 443.0 | 1218.0 | PHF5A%2C SF3B1 and SF3B5 |
| Hgene | SF3B3 | chr16:70578436 | chr16:67662273 | ENST00000302516 | + | 10 | 26 | 193_231 | 443.0 | 1218.0 | SF3B1 and SF3B5 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | SF3B3 | chr16:70578436 | chr16:67662273 | ENST00000302516 | + | 10 | 26 | 786_804 | 443.0 | 1218.0 | SF3B1 and SF3B5 |
| Hgene | SF3B3 | chr16:70578436 | chr16:67662273 | ENST00000302516 | + | 10 | 26 | 1028_1049 | 443.0 | 1218.0 | SF3B1 |
| Hgene | SF3B3 | chr16:70578436 | chr16:67662273 | ENST00000302516 | + | 10 | 26 | 1100_1123 | 443.0 | 1218.0 | SF3B5 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for SF3B3-CTCF |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SF3B3-CTCF |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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