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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SF3B3-DDX19B (FusionGDB2 ID:81069)

Fusion Gene Summary for SF3B3-DDX19B

Fusion gene summary

Fusion gene information	Fusion gene name: SF3B3-DDX19B
	Fusion gene ID: 81069
		Hgene	Tgene
	Gene symbol	SF3B3	DDX19B
	Gene ID	23450	11269
	Gene name	splicing factor 3b subunit 3	DEAD-box helicase 19B
	Synonyms	RSE1\|SAP130\|SF3b130\|STAF130	DBP5\|DDX19\|RNAh
	Cytomap	16q22.1	16q22.1
	Type of gene	protein-coding	protein-coding
	Description	splicing factor 3B subunit 3SAP 130pre-mRNA splicing factor SF3b, 130 kDa subunitspliceosome-associated protein 130	ATP-dependent RNA helicase DDX19BATP-dependent RNA helicase DDX19DEAD (Asp-Glu-Ala-As) box polypeptide 19BDEAD (Asp-Glu-Ala-Asp) box polypeptide 19BDEAD box protein 19BDEAD-box RNA helicase DEAD5DEAD-box protein 5DEAD/H (Asp-Glu-Ala-Asp/His) box po
	Modification date	20200313	20200313
	UniProtAcc	.	Q9UMR2
	Ensembl transtripts involved in fusion gene	ENST00000302516,	ENST00000451014, ENST00000563206, ENST00000570055, ENST00000288071, ENST00000393657, ENST00000563392, ENST00000568625, ENST00000355992,
Fusion gene scores	* DoF score	13 X 15 X 9=1755	7 X 9 X 8=504
	# samples	18	13
	** MAII score	log2(18/1755*10)=-3.28540221886225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/504*10)=-1.95491211047146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SF3B3 [Title/Abstract] AND DDX19B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SF3B3(70573110)-DDX19B(70346512), # samples:3
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SF3B3	GO:0000398	mRNA splicing, via spliceosome	28781166\|29360106
Hgene	SF3B3	GO:0042177	negative regulation of protein catabolic process	23951410

Fusion gene breakpoints across SF3B3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DDX19B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-G2-A2ES-01A	SF3B3	chr16	70572363	+	DDX19B	chr16	70346512	+
ChimerDB4	BLCA	TCGA-G2-A2ES-01A	SF3B3	chr16	70573110	-	DDX19B	chr16	70346512	+
ChimerDB4	BLCA	TCGA-G2-A2ES-01A	SF3B3	chr16	70573110	+	DDX19B	chr16	70346512	+
ChimerDB4	ESCA	TCGA-L5-A4OQ-01A	SF3B3	chr16	70573110	-	DDX19B	chr16	70346512	+
ChimerDB4	ESCA	TCGA-L5-A4OQ	SF3B3	chr16	70573110	+	DDX19B	chr16	70348804	+
ChimerDB4	GBM	TCGA-26-5133-01A	SF3B3	chr16	70595687	-	DDX19B	chr16	70358488	+
ChimerDB4	GBM	TCGA-26-5133-01A	SF3B3	chr16	70595687	+	DDX19B	chr16	70358488	+
ChimerDB4	OV	TCGA-24-0968-01A	SF3B3	chr16	70595687	+	DDX19B	chr16	70351399	+
ChimerDB4	OV	TCGA-24-0968	SF3B3	chr16	70595687	+	DDX19B	chr16	70351398	+

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Fusion Gene ORF analysis for SF3B3-DDX19B

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000302516	ENST00000451014	SF3B3	chr16	70572363	+	DDX19B	chr16	70346512	+
5CDS-3UTR	ENST00000302516	ENST00000451014	SF3B3	chr16	70573110	+	DDX19B	chr16	70346512	+
5CDS-3UTR	ENST00000302516	ENST00000451014	SF3B3	chr16	70573110	+	DDX19B	chr16	70348804	+
5CDS-3UTR	ENST00000302516	ENST00000563206	SF3B3	chr16	70572363	+	DDX19B	chr16	70346512	+
5CDS-3UTR	ENST00000302516	ENST00000563206	SF3B3	chr16	70573110	+	DDX19B	chr16	70346512	+
5CDS-3UTR	ENST00000302516	ENST00000563206	SF3B3	chr16	70573110	+	DDX19B	chr16	70348804	+
5CDS-3UTR	ENST00000302516	ENST00000563206	SF3B3	chr16	70595687	+	DDX19B	chr16	70351399	+
5CDS-3UTR	ENST00000302516	ENST00000563206	SF3B3	chr16	70595687	+	DDX19B	chr16	70351398	+
5CDS-3UTR	ENST00000302516	ENST00000570055	SF3B3	chr16	70572363	+	DDX19B	chr16	70346512	+
5CDS-3UTR	ENST00000302516	ENST00000570055	SF3B3	chr16	70573110	+	DDX19B	chr16	70346512	+
5CDS-3UTR	ENST00000302516	ENST00000570055	SF3B3	chr16	70573110	+	DDX19B	chr16	70348804	+
5CDS-3UTR	ENST00000302516	ENST00000570055	SF3B3	chr16	70595687	+	DDX19B	chr16	70351399	+
5CDS-3UTR	ENST00000302516	ENST00000570055	SF3B3	chr16	70595687	+	DDX19B	chr16	70351398	+
5CDS-5UTR	ENST00000302516	ENST00000288071	SF3B3	chr16	70573110	+	DDX19B	chr16	70348804	+
5CDS-5UTR	ENST00000302516	ENST00000288071	SF3B3	chr16	70595687	+	DDX19B	chr16	70351399	+
5CDS-5UTR	ENST00000302516	ENST00000288071	SF3B3	chr16	70595687	+	DDX19B	chr16	70351398	+
5CDS-5UTR	ENST00000302516	ENST00000393657	SF3B3	chr16	70595687	+	DDX19B	chr16	70351399	+
5CDS-5UTR	ENST00000302516	ENST00000393657	SF3B3	chr16	70595687	+	DDX19B	chr16	70351398	+
5CDS-5UTR	ENST00000302516	ENST00000563392	SF3B3	chr16	70595687	+	DDX19B	chr16	70351399	+
5CDS-5UTR	ENST00000302516	ENST00000563392	SF3B3	chr16	70595687	+	DDX19B	chr16	70351398	+
5CDS-5UTR	ENST00000302516	ENST00000568625	SF3B3	chr16	70573110	+	DDX19B	chr16	70348804	+
5CDS-5UTR	ENST00000302516	ENST00000568625	SF3B3	chr16	70595687	+	DDX19B	chr16	70351399	+
5CDS-5UTR	ENST00000302516	ENST00000568625	SF3B3	chr16	70595687	+	DDX19B	chr16	70351398	+
5CDS-intron	ENST00000302516	ENST00000288071	SF3B3	chr16	70572363	+	DDX19B	chr16	70346512	+
5CDS-intron	ENST00000302516	ENST00000288071	SF3B3	chr16	70573110	+	DDX19B	chr16	70346512	+
5CDS-intron	ENST00000302516	ENST00000288071	SF3B3	chr16	70595687	+	DDX19B	chr16	70358488	+
5CDS-intron	ENST00000302516	ENST00000355992	SF3B3	chr16	70572363	+	DDX19B	chr16	70346512	+
5CDS-intron	ENST00000302516	ENST00000355992	SF3B3	chr16	70573110	+	DDX19B	chr16	70346512	+
5CDS-intron	ENST00000302516	ENST00000355992	SF3B3	chr16	70573110	+	DDX19B	chr16	70348804	+
5CDS-intron	ENST00000302516	ENST00000355992	SF3B3	chr16	70595687	+	DDX19B	chr16	70358488	+
5CDS-intron	ENST00000302516	ENST00000355992	SF3B3	chr16	70595687	+	DDX19B	chr16	70351399	+
5CDS-intron	ENST00000302516	ENST00000355992	SF3B3	chr16	70595687	+	DDX19B	chr16	70351398	+
5CDS-intron	ENST00000302516	ENST00000393657	SF3B3	chr16	70572363	+	DDX19B	chr16	70346512	+
5CDS-intron	ENST00000302516	ENST00000393657	SF3B3	chr16	70573110	+	DDX19B	chr16	70346512	+
5CDS-intron	ENST00000302516	ENST00000393657	SF3B3	chr16	70573110	+	DDX19B	chr16	70348804	+
5CDS-intron	ENST00000302516	ENST00000393657	SF3B3	chr16	70595687	+	DDX19B	chr16	70358488	+
5CDS-intron	ENST00000302516	ENST00000451014	SF3B3	chr16	70595687	+	DDX19B	chr16	70358488	+
5CDS-intron	ENST00000302516	ENST00000451014	SF3B3	chr16	70595687	+	DDX19B	chr16	70351399	+
5CDS-intron	ENST00000302516	ENST00000451014	SF3B3	chr16	70595687	+	DDX19B	chr16	70351398	+
5CDS-intron	ENST00000302516	ENST00000563206	SF3B3	chr16	70595687	+	DDX19B	chr16	70358488	+
5CDS-intron	ENST00000302516	ENST00000563392	SF3B3	chr16	70572363	+	DDX19B	chr16	70346512	+
5CDS-intron	ENST00000302516	ENST00000563392	SF3B3	chr16	70573110	+	DDX19B	chr16	70346512	+
5CDS-intron	ENST00000302516	ENST00000563392	SF3B3	chr16	70573110	+	DDX19B	chr16	70348804	+
5CDS-intron	ENST00000302516	ENST00000568625	SF3B3	chr16	70572363	+	DDX19B	chr16	70346512	+
5CDS-intron	ENST00000302516	ENST00000568625	SF3B3	chr16	70573110	+	DDX19B	chr16	70346512	+
5CDS-intron	ENST00000302516	ENST00000568625	SF3B3	chr16	70595687	+	DDX19B	chr16	70358488	+
5CDS-intron	ENST00000302516	ENST00000570055	SF3B3	chr16	70595687	+	DDX19B	chr16	70358488	+
In-frame	ENST00000302516	ENST00000563392	SF3B3	chr16	70595687	+	DDX19B	chr16	70358488	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000302516

SF3B3

chr16

70595687

ENST00000563392

DDX19B

chr16

70358488

3788

2499

109

3549

1146

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000302516	ENST00000563392	SF3B3	chr16	70595687	+	DDX19B	chr16	70358488	+	0.000614961	0.999385

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Fusion Genomic Features for SF3B3-DDX19B

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SF3B3	chr16	70573110	+	DDX19B	chr16	70346511	+	4.69E-06	0.99999535
SF3B3	chr16	70595687	+	DDX19B	chr16	70351398	+	9.08E-07	0.99999905
SF3B3	chr16	70595687	+	DDX19B	chr16	70351398	+	9.08E-07	0.99999905
SF3B3	chr16	70573110	+	DDX19B	chr16	70348804	+	1.02E-08	1
SF3B3	chr16	70572363	+	DDX19B	chr16	70346511	+	8.64E-11	1
SF3B3	chr16	70595687	+	DDX19B	chr16	70358487	+	2.52E-08	1
SF3B3	chr16	70573110	+	DDX19B	chr16	70346511	+	4.69E-06	0.99999535
SF3B3	chr16	70595687	+	DDX19B	chr16	70351398	+	9.08E-07	0.99999905
SF3B3	chr16	70595687	+	DDX19B	chr16	70351398	+	9.08E-07	0.99999905
SF3B3	chr16	70573110	+	DDX19B	chr16	70348804	+	1.02E-08	1
SF3B3	chr16	70572363	+	DDX19B	chr16	70346511	+	8.64E-11	1
SF3B3	chr16	70595687	+	DDX19B	chr16	70358487	+	2.52E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SF3B3-DDX19B

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:70573110/chr16:70346512)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	DDX19B Q9UMR2
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: ATP-dependent RNA helicase involved in mRNA export from the nucleus (PubMed:10428971). Rather than unwinding RNA duplexes, DDX19B functions as a remodeler of ribonucleoprotein particles, whereby proteins bound to nuclear mRNA are dissociated and replaced by cytoplasmic mRNA binding proteins (PubMed:10428971). {ECO:0000269\|PubMed:10428971}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000288071

306_474

129

480.0

Domain

Helicase C-terminal

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000355992

125_295

449.0

Domain

Helicase ATP-binding

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000355992

306_474

449.0

Domain

Helicase C-terminal

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000393657

125_295

371.0

Domain

Helicase ATP-binding

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000393657

306_474

371.0

Domain

Helicase C-terminal

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000451014

125_295

103

454.0

Domain

Helicase ATP-binding

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000451014

306_474

103

454.0

Domain

Helicase C-terminal

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000563392

125_295

371.0

Domain

Helicase ATP-binding

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000563392

306_474

371.0

Domain

Helicase C-terminal

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000568625

125_295

371.0

Domain

Helicase ATP-binding

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000568625

306_474

371.0

Domain

Helicase C-terminal

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000288071

242_245

129

480.0

Motif

Note=DEAD box

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000355992

242_245

449.0

Motif

Note=DEAD box

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000393657

242_245

371.0

Motif

Note=DEAD box

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000393657

92_120

371.0

Motif

Note=Q motif

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000451014

242_245

103

454.0

Motif

Note=DEAD box

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000563392

242_245

371.0

Motif

Note=DEAD box

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000563392

92_120

371.0

Motif

Note=Q motif

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000568625

242_245

371.0

Motif

Note=DEAD box

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000568625

92_120

371.0

Motif

Note=Q motif

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000288071

138_145

129

480.0

Nucleotide binding

Note=ATP

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000355992

138_145

449.0

Nucleotide binding

Note=ATP

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000393657

138_145

371.0

Nucleotide binding

Note=ATP

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000451014

138_145

103

454.0

Nucleotide binding

Note=ATP

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000563392

138_145

371.0

Nucleotide binding

Note=ATP

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000568625

138_145

371.0

Nucleotide binding

Note=ATP

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000288071

301_479

129

480.0

Region

Note=C-terminal lobe

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000355992

301_479

449.0

Region

Note=C-terminal lobe

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000393657

301_479

371.0

Region

Note=C-terminal lobe

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000393657

55_68

371.0

Region

Note=N-terminal helix

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000451014

301_479

103

454.0

Region

Note=C-terminal lobe

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000563392

301_479

371.0

Region

Note=C-terminal lobe

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000563392

55_68

371.0

Region

Note=N-terminal helix

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000568625

301_479

371.0

Region

Note=C-terminal lobe

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000568625

55_68

371.0

Region

Note=N-terminal helix

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000288071

125_295

129

480.0

Domain

Helicase ATP-binding

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000288071

92_120

129

480.0

Motif

Note=Q motif

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000355992

92_120

449.0

Motif

Note=Q motif

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000451014

92_120

103

454.0

Motif

Note=Q motif

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000288071

2_300

129

480.0

Region

Note=N-terminal lobe

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000288071

55_68

129

480.0

Region

Note=N-terminal helix

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000355992

2_300

449.0

Region

Note=N-terminal lobe

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000355992

55_68

449.0

Region

Note=N-terminal helix

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000393657

2_300

371.0

Region

Note=N-terminal lobe

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000451014

2_300

103

454.0

Region

Note=N-terminal lobe

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000451014

55_68

103

454.0

Region

Note=N-terminal helix

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000563392

2_300

371.0

Region

Note=N-terminal lobe

Tgene

DDX19B

chr16:70595687

chr16:70358488

ENST00000568625

2_300

371.0

Region

Note=N-terminal lobe

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Fusion Gene Sequence for SF3B3-DDX19B

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>81069_81069_1_SF3B3-DDX19B_SF3B3_chr16_70595687_ENST00000302516_DDX19B_chr16_70358488_ENST00000563392_length(transcript)=3788nt_BP=2499nt
GCCTTTTTCCGCCGCGCGCCACCAGAATGTCCCTGTCTTGAGGTCTAATGGCGGACGCCAGTATGTTGGAGTTGGTGGTGGCTTAAGTTT
TGAAGGGAGGTAGCATCCGTTGGATATCCACACCATCCTTCTCGCTGCAGGCTTTCTTGGACTCCGTACTGTTGGTGTAACCAAGGCCTG
GAGGTCTGGGTGGCTCAGGTTTCCTGCAGCCATGTTTCTGTACAACTTAACCTTGCAGAGAGCCACTGGCATCAGCTTTGCCATTCATGG
AAACTTTTCTGGAACCAAACAACAAGAAATTGTTGTTTCCCGTGGGAAGATCTTGGAGCTGCTTCGCCCAGACCCCAACACTGGCAAAGT
ACATACCCTACTCACTGTGGAAGTATTCGGTGTTATCCGGTCACTCATGGCCTTTAGGCTGACAGGTGGCACCAAAGACTACATTGTAGT
TGGCAGTGACTCTGGTCGAATTGTTATTTTGGAATACCAGCCATCTAAGAATATGTTTGAGAAGATTCACCAAGAAACCTTTGGCAAGAG
TGGATGCCGTCGCATCGTTCCTGGCCAGTTCTTAGCTGTGGATCCCAAAGGGCGAGCCGTTATGATTAGTGCCATTGAGAAACAGAAATT
GGTGTATATTTTGAACAGAGATGCTGCAGCCCGACTTACCATTTCATCTCCCCTGGAAGCCCACAAAGCAAACACTTTAGTGTATCATGT
AGTTGGAGTAGATGTCGGATTTGAAAATCCAATGTTTGCTTGTCTGGAAATGGATTATGAGGAAGCAGACAATGATCCAACAGGGGAAGC
AGCAGCTAATACCCAGCAGACACTTACTTTCTATGAGCTAGACCTTGGTTTAAATCATGTGGTCCGAAAATACAGTGAACCTTTGGAGGA
ACACGGCAACTTCCTTATTACAGTTCCAGGAGGGTCAGATGGTCCAAGTGGAGTACTGATCTGCTCTGAAAACTATATTACTTACAAGAA
CTTTGGTGACCAGCCAGATATCCGCTGTCCAATTCCCAGGAGGCGGAATGACCTGGATGACCCTGAAAGAGGAATGATTTTTGTCTGCTC
TGCAACCCATAAAACCAAATCGATGTTCTTCTTTTTGGCTCAAACTGAGCAGGGAGATATCTTTAAGATCACTTTGGAGACAGATGAAGA
TATGGTTACTGAGATCCGGCTCAAATATTTTGATACTGTACCCGTTGCTGCTGCCATGTGTGTGCTTAAAACAGGGTTCCTTTTTGTAGC
ATCAGAATTTGGAAACCATTACTTATATCAAATTGCACATCTTGGAGATGATGATGAAGAACCTGAGTTTTCATCAGCCATGCCTCTGGA
AGAAGGAGACACATTCTTTTTTCAGCCAAGACCACTTAAAAACCTTGTGCTGGTTGATGAGTTGGACAGCCTCTCTCCCATTCTGTTTTG
CCAGATAGCTGATCTGGCCAATGAAGATACTCCACAGTTGTATGTGGCCTGTGGTAGGGGACCCCGATCATCTCTGAGAGTCCTAAGACA
TGGACTTGAGGTGTCAGAAATGGCTGTTTCTGAGCTACCTGGTAACCCCAACGCTGTCTGGACAGTGCGTCGACACATTGAAGATGAGTT
TGATGCCTACATCATTGTGTCTTTCGTGAATGCCACCCTAGTGTTGTCCATTGGAGAAACTGTAGAAGAAGTGACTGACTCTGGGTTCCT
GGGGACCACCCCGACCTTGTCCTGCTCCTTATTAGGAGATGATGCCTTGGTGCAGGTCTATCCAGATGGCATTCGGCACATACGAGCAGA
CAAGAGAGTCAATGAGTGGAAGACCCCTGGAAAGAAAACAATTGTGAAGTGTGCAGTGAACCAGCGACAAGTGGTGATTGCCCTGACAGG
AGGAGAGCTGGTCTATTTCGAGATGGATCCTTCAGGACAGCTGAATGAGTACACAGAACGGAAGGAGATGTCAGCAGATGTGGTGTGCAT
GAGTCTGGCCAATGTACCCCCTGGAGAGCAGCGGTCTCGCTTCCTGGCTGTGGGGCTTGTGGACAACACTGTCAGAATCATCTCCCTGGA
TCCCTCAGACTGTTTGCAACCTCTAAGCATGCAGGCTCTCCCAGCCCAGCCTGAGTCCTTGTGTATCGTGGAAATGGGTGGGACTGAGAA
GCAGGATGAGCTGGGTGAGAGGGGCTCGATTGGCTTCCTATACCTGAATATTGGGCTACAGAACGGTGTGCTGCTGAGGACTGTCTTGGA
CCCTGTCACTGGGGATTTGTCTGATACTCGCACTCGGTACCTGGGGTCCCGTCCTGTGAAGCTCTTCCGAGTCCGAATGCAAGGCCAGGA
GGCAGTATTGGCCATGTCAAGCCGCTCATGGTTGAGCTATTCTTACCAATCTCGCTTCCATCTCACCCCACTGTCTTACGAGACACTGGA
ATTTGCATCGGGTTTTGCCTCGGAACAGTGTCCCGAGGGCATTGTGGCCATCTCCACCAACACCCTACGCCCACAGAACTTAATTGCCCA
ATCTCAGTCTGGTACTGGTAAAACAGCTGCCTTCGTGCTGGCCATGCTTAGCCAAGTAGAACCTGCAAACAAATACCCCCAGTGTCTATG
TCTCTCCCCAACGTATGAGCTCGCCCTCCAAACAGGAAAAGTGATTGAACAAATGGGCAAATTTTACCCTGAACTGAAGCTAGCTTATGC
TGTTCGAGGCAATAAATTGGAAAGAGGCCAGAAGATCAGTGAGCAGATTGTCATTGGCACCCCTGGGACTGTGCTGGACTGGTGCTCCAA
GCTCAAGTTCATTGATCCCAAGAAAATCAAGGTGTTTGTTCTGGATGAGGCTGATGTCATGATAGCCACTCAGGGCCACCAAGATCAGAG
CATCCGCATCCAGAGGATGCTGCCCAGGAACTGCCAGATGCTGCTTTTCTCCGCCACCTTTGAAGACTCTGTGTGGAAGTTTGCCCAGAA
AGTGGTCCCAGACCCAAACGTTATCAAACTGAAGCGTGAGGAAGAGACCCTGGACACCATCAAGCAGTACTATGTCCTGTGCAGCAGCAG
AGACGAGAAGTTCCAGGCCTTGTGTAACCTCTACGGGGCCATCACCATTGCTCAAGCCATGATCTTCTGCCATACTCGCAAAACAGCTAG
TTGGCTGGCAGCAGAGCTCTCAAAAGAAGGCCACCAGGTGGCTCTGCTGAGTGGGGAGATGATGGTGGAACAGAGGGCTGCAGTGATTGA
GCGCTTCCGAGAGGGCAAAGAGAAGGTTTTGGTGACCACCAACGTGTGTGCCCGCGGCATTGATGTTGAACAAGTGTCTGTCGTCATCAA
CTTTGATCTTCCCGTGGACAAGGACGGGAATCCTGACAATGAGACCTACCTGCACCGGATCGGGCGCACGGGCCGCTTTGGCAAGAGGGG
CCTGGCAGTGAACATGGTGGACAGCAAGCACAGCATGAACATCCTGAACAGAATCCAGGAGCATTTTAATAAGAAGATAGAAAGATTGGA
CACAGATGATTTGGACGAGATTGAGAAAATAGCCAACTGAGAAGCTCCACCAGCCACTGATGCCAGCCCTGGCACTGCCCCTGCACAGGA
GACAAGTGCGTTCAGGGCACAGGCCCCGACATCACCCCAAGGACAACGGCACAAGTAGAGAGAAACTACCTACCTCACTTCAAATTATGT
TTGGACTTGACAAAAATGTATGCAAATGATGGGGGATGGTAGAAAAAAATTATTTACACAACCTTGGAAGATTAGGCATGAATACACAGA

>81069_81069_1_SF3B3-DDX19B_SF3B3_chr16_70595687_ENST00000302516_DDX19B_chr16_70358488_ENST00000563392_length(amino acids)=1146AA_BP=797
MDIHTILLAAGFLGLRTVGVTKAWRSGWLRFPAAMFLYNLTLQRATGISFAIHGNFSGTKQQEIVVSRGKILELLRPDPNTGKVHTLLTV
EVFGVIRSLMAFRLTGGTKDYIVVGSDSGRIVILEYQPSKNMFEKIHQETFGKSGCRRIVPGQFLAVDPKGRAVMISAIEKQKLVYILNR
DAAARLTISSPLEAHKANTLVYHVVGVDVGFENPMFACLEMDYEEADNDPTGEAAANTQQTLTFYELDLGLNHVVRKYSEPLEEHGNFLI
TVPGGSDGPSGVLICSENYITYKNFGDQPDIRCPIPRRRNDLDDPERGMIFVCSATHKTKSMFFFLAQTEQGDIFKITLETDEDMVTEIR
LKYFDTVPVAAAMCVLKTGFLFVASEFGNHYLYQIAHLGDDDEEPEFSSAMPLEEGDTFFFQPRPLKNLVLVDELDSLSPILFCQIADLA
NEDTPQLYVACGRGPRSSLRVLRHGLEVSEMAVSELPGNPNAVWTVRRHIEDEFDAYIIVSFVNATLVLSIGETVEEVTDSGFLGTTPTL
SCSLLGDDALVQVYPDGIRHIRADKRVNEWKTPGKKTIVKCAVNQRQVVIALTGGELVYFEMDPSGQLNEYTERKEMSADVVCMSLANVP
PGEQRSRFLAVGLVDNTVRIISLDPSDCLQPLSMQALPAQPESLCIVEMGGTEKQDELGERGSIGFLYLNIGLQNGVLLRTVLDPVTGDL
SDTRTRYLGSRPVKLFRVRMQGQEAVLAMSSRSWLSYSYQSRFHLTPLSYETLEFASGFASEQCPEGIVAISTNTLRPQNLIAQSQSGTG
KTAAFVLAMLSQVEPANKYPQCLCLSPTYELALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKISEQIVIGTPGTVLDWCSKLKFIDP
KKIKVFVLDEADVMIATQGHQDQSIRIQRMLPRNCQMLLFSATFEDSVWKFAQKVVPDPNVIKLKREEETLDTIKQYYVLCSSRDEKFQA
LCNLYGAITIAQAMIFCHTRKTASWLAAELSKEGHQVALLSGEMMVEQRAAVIERFREGKEKVLVTTNVCARGIDVEQVSVVINFDLPVD

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SF3B3-DDX19B

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Still interaction with
Hgene	SF3B3	chr16:70595687	chr16:70358488	ENST00000302516	+	17	26	105_119	762.6666666666666	1218.0	PHF5A%2C SF3B1 and SF3B5
Hgene	SF3B3	chr16:70595687	chr16:70358488	ENST00000302516	+	17	26	145_168	762.6666666666666	1218.0	PHF5A%2C SF3B1 and SF3B5
Hgene	SF3B3	chr16:70595687	chr16:70358488	ENST00000302516	+	17	26	193_231	762.6666666666666	1218.0	SF3B1 and SF3B5

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	SF3B3	chr16:70595687	chr16:70358488	ENST00000302516	+	17	26	786_804	762.6666666666666	1218.0	SF3B1 and SF3B5
Hgene	SF3B3	chr16:70595687	chr16:70358488	ENST00000302516	+	17	26	1028_1049	762.6666666666666	1218.0	SF3B1
Hgene	SF3B3	chr16:70595687	chr16:70358488	ENST00000302516	+	17	26	1100_1123	762.6666666666666	1218.0	SF3B5

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SF3B3-DDX19B

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SF3B3-DDX19B

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source