Home

Download

Statistics

Examples

Help

Contact

	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SFMBT1-WNT7A (FusionGDB2 ID:81106)

Fusion Gene Summary for SFMBT1-WNT7A

Fusion gene summary

Fusion gene information	Fusion gene name: SFMBT1-WNT7A
	Fusion gene ID: 81106
		Hgene	Tgene
	Gene symbol	SFMBT1	WNT7A
	Gene ID	51460	7476
	Gene name	Scm like with four mbt domains 1	Wnt family member 7A
	Synonyms	RU1\|SFMBT\|hSFMBT	Wnt-7a
	Cytomap	3p21.1	3p25.1
	Type of gene	protein-coding	protein-coding
	Description	scm-like with four MBT domains protein 1Scm-related gene containing four mbt domainsScm-related gene product containing four mbt domainsrenal ubiquitous protein 1	protein Wnt-7aproto-oncogene Wnt7a proteinwingless-type MMTV integration site family, member 7A
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000296295, ENST00000358080, ENST00000394750, ENST00000394752, ENST00000470575,	ENST00000497808, ENST00000285018,
Fusion gene scores	* DoF score	18 X 15 X 11=2970	4 X 3 X 4=48
	# samples	22	6
	** MAII score	log2(22/2970*10)=-3.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/48*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SFMBT1 [Title/Abstract] AND WNT7A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SFMBT1(53003117)-WNT7A(13916670), # samples:3
Anticipated loss of major functional domain due to fusion event.	SFMBT1-WNT7A seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. SFMBT1-WNT7A seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. SFMBT1-WNT7A seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SFMBT1	GO:0045892	negative regulation of transcription, DNA-templated	23592795
Tgene	WNT7A	GO:0001502	cartilage condensation	17202865
Tgene	WNT7A	GO:0002062	chondrocyte differentiation	17202865
Tgene	WNT7A	GO:0021846	cell proliferation in forebrain	12843296
Tgene	WNT7A	GO:0032270	positive regulation of cellular protein metabolic process	16805831
Tgene	WNT7A	GO:0035313	wound healing, spreading of epidermal cells	15802269
Tgene	WNT7A	GO:0045893	positive regulation of transcription, DNA-templated	15802269
Tgene	WNT7A	GO:0045944	positive regulation of transcription by RNA polymerase II	12857724
Tgene	WNT7A	GO:0048864	stem cell development	12843296
Tgene	WNT7A	GO:0050768	negative regulation of neurogenesis	12843296
Tgene	WNT7A	GO:0051965	positive regulation of synapse assembly	18986540
Tgene	WNT7A	GO:0060054	positive regulation of epithelial cell proliferation involved in wound healing	15802269
Tgene	WNT7A	GO:0060070	canonical Wnt signaling pathway	12857724\|15802269\|16805831\|18986540\|28733458
Tgene	WNT7A	GO:0060071	Wnt signaling pathway, planar cell polarity pathway	15802269
Tgene	WNT7A	GO:0060997	dendritic spine morphogenesis	21670302
Tgene	WNT7A	GO:1904891	positive regulation of excitatory synapse assembly	21670302
Tgene	WNT7A	GO:1905606	regulation of presynapse assembly	20530549
Tgene	WNT7A	GO:2000463	positive regulation of excitatory postsynaptic potential	21670302

Fusion gene breakpoints across SFMBT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WNT7A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-38-4630-01A	SFMBT1	chr3	53003117	-	WNT7A	chr3	13896300	-
ChimerDB4	LUAD	TCGA-38-4630-01A	SFMBT1	chr3	53003117	-	WNT7A	chr3	13916670	-

Top

Fusion Gene ORF analysis for SFMBT1-WNT7A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000296295	ENST00000497808	SFMBT1	chr3	53003117	-	WNT7A	chr3	13916670	-
5CDS-5UTR	ENST00000358080	ENST00000497808	SFMBT1	chr3	53003117	-	WNT7A	chr3	13916670	-
5CDS-5UTR	ENST00000394750	ENST00000497808	SFMBT1	chr3	53003117	-	WNT7A	chr3	13916670	-
5CDS-5UTR	ENST00000394752	ENST00000497808	SFMBT1	chr3	53003117	-	WNT7A	chr3	13916670	-
5CDS-intron	ENST00000296295	ENST00000497808	SFMBT1	chr3	53003117	-	WNT7A	chr3	13896300	-
5CDS-intron	ENST00000358080	ENST00000497808	SFMBT1	chr3	53003117	-	WNT7A	chr3	13896300	-
5CDS-intron	ENST00000394750	ENST00000497808	SFMBT1	chr3	53003117	-	WNT7A	chr3	13896300	-
5CDS-intron	ENST00000394752	ENST00000497808	SFMBT1	chr3	53003117	-	WNT7A	chr3	13896300	-
5UTR-3CDS	ENST00000470575	ENST00000285018	SFMBT1	chr3	53003117	-	WNT7A	chr3	13896300	-
5UTR-3CDS	ENST00000470575	ENST00000285018	SFMBT1	chr3	53003117	-	WNT7A	chr3	13916670	-
5UTR-5UTR	ENST00000470575	ENST00000497808	SFMBT1	chr3	53003117	-	WNT7A	chr3	13916670	-
5UTR-intron	ENST00000470575	ENST00000497808	SFMBT1	chr3	53003117	-	WNT7A	chr3	13896300	-
Frame-shift	ENST00000296295	ENST00000285018	SFMBT1	chr3	53003117	-	WNT7A	chr3	13916670	-
Frame-shift	ENST00000358080	ENST00000285018	SFMBT1	chr3	53003117	-	WNT7A	chr3	13896300	-
Frame-shift	ENST00000358080	ENST00000285018	SFMBT1	chr3	53003117	-	WNT7A	chr3	13916670	-
Frame-shift	ENST00000394750	ENST00000285018	SFMBT1	chr3	53003117	-	WNT7A	chr3	13896300	-
Frame-shift	ENST00000394750	ENST00000285018	SFMBT1	chr3	53003117	-	WNT7A	chr3	13916670	-
Frame-shift	ENST00000394752	ENST00000285018	SFMBT1	chr3	53003117	-	WNT7A	chr3	13916670	-
In-frame	ENST00000296295	ENST00000285018	SFMBT1	chr3	53003117	-	WNT7A	chr3	13896300	-
In-frame	ENST00000394752	ENST00000285018	SFMBT1	chr3	53003117	-	WNT7A	chr3	13896300	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000394752	SFMBT1	chr3	53003117	-	ENST00000285018	WNT7A	chr3	13896300	-	3849	411	344	1162	272
ENST00000296295	SFMBT1	chr3	53003117	-	ENST00000285018	WNT7A	chr3	13896300	-	3835	397	330	1148	272

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000394752	ENST00000285018	SFMBT1	chr3	53003117	-	WNT7A	chr3	13896300	-	0.001627582	0.9983725
ENST00000296295	ENST00000285018	SFMBT1	chr3	53003117	-	WNT7A	chr3	13896300	-	0.001621807	0.99837816

Top

Fusion Genomic Features for SFMBT1-WNT7A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

Top

Fusion Protein Features for SFMBT1-WNT7A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:53003117/chr3:13916670)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

WNT7A

chr3:53003117

chr3:13896300

ENST00000285018

238_266

350.0

Region

Intrinsically disordered linker

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000296295

796_864

824.0

Domain

Note=SAM

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000358080

796_864

867.0

Domain

Note=SAM

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000394750

796_864

867.0

Domain

Note=SAM

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000394752

796_864

867.0

Domain

Note=SAM

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000296295

34_42

824.0

Region

Note=Antigenic epitope

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000358080

34_42

867.0

Region

Note=Antigenic epitope

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000394750

34_42

867.0

Region

Note=Antigenic epitope

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000394752

34_42

867.0

Region

Note=Antigenic epitope

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000296295

128_232

824.0

Repeat

Note=MBT 2

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000296295

20_120

824.0

Repeat

Note=MBT 1

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000296295

242_348

824.0

Repeat

Note=MBT 3

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000296295

356_453

824.0

Repeat

Note=MBT 4

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000358080

128_232

867.0

Repeat

Note=MBT 2

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000358080

20_120

867.0

Repeat

Note=MBT 1

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000358080

242_348

867.0

Repeat

Note=MBT 3

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000358080

356_453

867.0

Repeat

Note=MBT 4

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000394750

128_232

867.0

Repeat

Note=MBT 2

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000394750

20_120

867.0

Repeat

Note=MBT 1

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000394750

242_348

867.0

Repeat

Note=MBT 3

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000394750

356_453

867.0

Repeat

Note=MBT 4

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000394752

128_232

867.0

Repeat

Note=MBT 2

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000394752

20_120

867.0

Repeat

Note=MBT 1

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000394752

242_348

867.0

Repeat

Note=MBT 3

Hgene

SFMBT1

chr3:53003117

chr3:13896300

ENST00000394752

356_453

867.0

Repeat

Note=MBT 4

Top

Fusion Gene Sequence for SFMBT1-WNT7A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>81106_81106_1_SFMBT1-WNT7A_SFMBT1_chr3_53003117_ENST00000296295_WNT7A_chr3_13896300_ENST00000285018_length(transcript)=3835nt_BP=397nt
CGCGGAGCGCCGCCGCCGCCTCCGCCGGAGCGCGGGTGGAGGGGGGCGGGGAGAGCTGCCGGCCGCCCCGCTCCGCCGAACCCAGCAGGA
AGGAGGGCGCGAGCGGGCGAGCGCGGGCAGCACGGGAGGAAAAAGCTTCCGCGCGGGGGAGCGAAAAGACGGAAAGAAAGAAAGAAAACG
AGCGCGAGAGGGGGAAAAGCGAGCGATCGAGCGAGCGCGCGCGCGAAAACTCCGGGCAGCACTTTCATTTGGACCCGTGGATACCCATTG
AACAGATGCTTGAAACCTGCAAGTAATCTTCAGATCCTAGCAGAACCATAGGCCTTTCCTTTGTTTTGGGAGGATATAGCCTGCCTATAT
GCTGTGGAAATGAACGGGGAGCAGCAGCTTGATGCAGGGAGCCGGGAGGCTGCGTTCACCTACGCCATCATTGCCGCCGGCGTGGCCCAC
GCCATCACAGCTGCCTGTACCCAGGGCAACCTGAGCGACTGTGGCTGCGACAAAGAGAAGCAAGGCCAGTACCACCGGGACGAGGGCTGG
AAGTGGGGTGGCTGCTCTGCCGACATCCGCTACGGCATCGGCTTCGCCAAGGTCTTTGTGGATGCCCGGGAGATCAAGCAGAATGCCCGG
ACTCTCATGAACTTGCACAACAACGAGGCAGGCCGAAAGATCCTGGAGGAGAACATGAAGCTGGAATGTAAGTGCCACGGCGTGTCAGGC
TCGTGCACCACCAAGACGTGCTGGACCACACTGCCACAGTTTCGGGAGCTGGGCTACGTGCTCAAGGACAAGTACAACGAGGCCGTTCAC
GTGGAGCCTGTGCGTGCCAGCCGCAACAAGCGGCCCACCTTCCTGAAGATCAAGAAGCCACTGTCGTACCGCAAGCCCATGGACACGGAC
CTGGTGTACATCGAGAAGTCGCCCAACTACTGCGAGGAGGACCCGGTGACCGGCAGTGTGGGCACCCAGGGCCGCGCCTGCAACAAGACG
GCTCCCCAGGCCAGCGGCTGTGACCTCATGTGCTGTGGGCGTGGCTACAACACCCACCAGTACGCCCGCGTGTGGCAGTGCAACTGTAAG
TTCCACTGGTGCTGCTATGTCAAGTGCAACACGTGCAGCGAGCGCACGGAGATGTACACGTGCAAGTGAGCCCCGTGTGCACACCACCCT
CCCGCTGCAAGTCAGATTGCTGGGAGGACTGGACCGTTTCCAAGCTGCGGGCTCCCTGGCAGGATGCTGAGCTTGTCTTTTCTGCTGAGG
AGGGTACTTTTCCTGGGTTTCCTGCAGGCATCCGTGGGGGAAAAAAAATCTCTCAGAGCCCTCAACTATTCTGTTCCACACCCAATGCTG
CTCCACCCTCCCCCAGACACAGCCCAGGTCCCTCCGCGGCTGGAGCGAAGCCTTCTGCAGCAGGAACTCTGGACCCCTGGGCCTCATCAC
AGCAATATTTAACAATTTATTCTGATAAAAATAATATTAATTTATTTAATTAAAAAGAATTCTTCCACCTCGTCGGGATCCGTTTTCTGC
AATCAAAGTGGACTGCTTGCTTTCCTAGCAGGATGATTTTGTTGCTAGGACAAGGAGCCGTGTAGAAGTGTACATAACTATTCTTTATGC
AGATATTTCTACTAGCTGATTTTGCAGGTACCCACCTTGCAGCACTAGATGTTTAAGTACAAGAGGAGACATCTTTTATGCATATATAGA
TATACACACACACATTTTTTTTTTTTTTTTTGCTGTTTGCTGCTACTTATCCAGAAATTTAAGCTGGTCCAGATTTGGAGACGTTTTTTC
CAGAGTATGTTTTCCATCCTTTTGCCCTCCCCAGTTCAAACTTCACCATTAGAAAAATCCAGTTTGGAATAAATAGAGAGGAAAAATAAT
AAATTCCCAGCAGTTTCCATCTTTCGGAAAGTGAGCCACCGGATAAGAGAGAATATTTTGTAAGAGACTATTTTTATATGAATATTTTAT
TTATATCGAGTCTACTGTATCATTCCACGGCCTGTGCTTCTTCTTAATTCTGGTACTCACTTAGGGGTAAGGAGGGGCGATGCCTGGTTG
TGGCGTCAGGCCCCATGGGGCCCCTTGCACAGCTGGATTCTTGAGTTCTGTTTGCCAAGTGGGCACAAGCTGCCCCTGGATGCCTGGGGT
TGAGGCATCATCTCATCCATGTTAGCCGGGAAAGAAATCAAATCCCCAGCCTCAGCCTGTTAAGCTCAGGCCTTTCAAGCAGGGCCACTG
AGTGGTAGCTTCGAAATGAGTCACTGTGGTGGGTGGTCATCGTGCCCCTCACAGGGACTTGACCGTCATCCTGCAGCAGAGGCCAGTTCA
GGGAGCCCCACACCTCACCAAGACACTAGCCATTGCCTGCGTGTCCTGGAAGGTGAGATGTAGTCCTCAGGTGAGGTGACCCAAAGCAGA
TGGGGTGAGGGGCCGATGAGCAGCCGGGCCCAGCGGGGCTTCCTGGATATCCTGCTCCCAAGGCCAAGCAGCAGAGAGAGGTTCAAGTGA
GGCCACTTTGCTTTGGGTCCAGCTACACCCAGAGCCTCAGCCTAGAAAGCTGTCCTCCAGCAGGCTGGGGGTGTTCTAATATGTGTCCGT
TTGCATTTCCGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTACTGTATCTTCTTAGGGACTTGAGTGTAGTC
ACGTGACTTTGCGCCTTGCAGCGCCTCCGCCGTACTCGTGTGTGTATGTGTCTGTGTGTTTCCGTGCTACCCAAGCGTCTGTTTCTCTCC
GTGTGCCTGGGAGATCAGGTCTCAGGCATGGAGCTGCATGCCTTTGCATCTGCTGCTCCCCAGAGTCTCTGCTTGCATGTGAGGGCTGGT
GGTATGAGGCAGACAGCAGAGATTGTGTGTGATTGTGTTGAACCGCCAAGAGAAGGCACCTCTGAACTCTGTCCCCACACCCATGGGTGA
AAACCAGACACCTCTGAGACCACAGCACAGCCCCATGGCCCCACCTGCTGGGAGCCCTTCAGTATCTAGGCTGTGTCTGACTCCTCAGTG
TCCACACTGAGCCTGGATCACAGCATGGGCAAATAAAAGTGACTGGATGGTTGCATGGTTTCTTCCCTTGGACATTTTTTTCCATTTTTC
TTTTACTTGGGTGTCTGGAGGAGTGGGCATGTGAAGGGGCCATGGAGTGAATGGATGGAGGGATGGATGAATGTGTGAGTAGGTAGGTAG
GTGAATGGGTAGATGTGTGGATGGATAAGTAGGTGGGTGGGTGAATGGATAAATGGATGGATGGGTAGATGGATGGATGAAGGGATAAAC
AGATGGGTGGATGGATTGATAAGTGAGCGGATGAATGGATGAATAGCTAGGAAAGTGGGTGGGTGGATGAGGGTGGGTTGATGAGGTAGG
TACACCTACAGATAGGTAAGTGAGCAGTTTCTTGGGAGTCCACAGGTCACATTTTATCTTTGCTTTGGAAAACCTAGCAGATCTGCCATG
ATCAGGATGGCTTCCCGACCTTGCAACCCTTCTGCTTCTGACCTCCTTGGCACCTGGGAATGGGGGAGATTCTGACCAGCCTCCCCAGAT
GAGTGTTCAATGATAGTTACATAAACACAGTCTCAGAAGAGTCATCCCTGTGTCCTCCCTCACTGTGGGTTCCCAGCTCTGGGGCCTGCC
CTCTCTCGGGTGCCCTGTTCAGCTGTGCTCTGAGCCCCAGTTTCTCCACCTGTGAAATCAGAATAACACCTACCTCACAGGGCTGTTGTG

>81106_81106_1_SFMBT1-WNT7A_SFMBT1_chr3_53003117_ENST00000296295_WNT7A_chr3_13896300_ENST00000285018_length(amino acids)=272AA_BP=19
MFWEDIACLYAVEMNGEQQLDAGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFV
DAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKP
LSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYT

--------------------------------------------------------------
>81106_81106_2_SFMBT1-WNT7A_SFMBT1_chr3_53003117_ENST00000394752_WNT7A_chr3_13896300_ENST00000285018_length(transcript)=3849nt_BP=411nt
GGAATGAGTCGGAGCGCGGAGCGCCGCCGCCGCCTCCGCCGGAGCGCGGGTGGAGGGGGGCGGGGAGAGCTGCCGGCCGCCCCGCTCCGC
CGAACCCAGCAGGAAGGAGGGCGCGAGCGGGCGAGCGCGGGCAGCACGGGAGGAAAAAGCTTCCGCGCGGGGGAGCGAAAAGACGGAAAG
AAAGAAAGAAAACGAGCGCGAGAGGGGGAAAAGCGAGCGATCGAGCGAGCGCGCGCGCGAAAACTCCGGGCAGCACTTTCATTTGGACCC
GTGGATACCCATTGAACAGATGCTTGAAACCTGCAAGTAATCTTCAGATCCTAGCAGAACCATAGGCCTTTCCTTTGTTTTGGGAGGATA
TAGCCTGCCTATATGCTGTGGAAATGAACGGGGAGCAGCAGCTTGATGCAGGGAGCCGGGAGGCTGCGTTCACCTACGCCATCATTGCCG
CCGGCGTGGCCCACGCCATCACAGCTGCCTGTACCCAGGGCAACCTGAGCGACTGTGGCTGCGACAAAGAGAAGCAAGGCCAGTACCACC
GGGACGAGGGCTGGAAGTGGGGTGGCTGCTCTGCCGACATCCGCTACGGCATCGGCTTCGCCAAGGTCTTTGTGGATGCCCGGGAGATCA
AGCAGAATGCCCGGACTCTCATGAACTTGCACAACAACGAGGCAGGCCGAAAGATCCTGGAGGAGAACATGAAGCTGGAATGTAAGTGCC
ACGGCGTGTCAGGCTCGTGCACCACCAAGACGTGCTGGACCACACTGCCACAGTTTCGGGAGCTGGGCTACGTGCTCAAGGACAAGTACA
ACGAGGCCGTTCACGTGGAGCCTGTGCGTGCCAGCCGCAACAAGCGGCCCACCTTCCTGAAGATCAAGAAGCCACTGTCGTACCGCAAGC
CCATGGACACGGACCTGGTGTACATCGAGAAGTCGCCCAACTACTGCGAGGAGGACCCGGTGACCGGCAGTGTGGGCACCCAGGGCCGCG
CCTGCAACAAGACGGCTCCCCAGGCCAGCGGCTGTGACCTCATGTGCTGTGGGCGTGGCTACAACACCCACCAGTACGCCCGCGTGTGGC
AGTGCAACTGTAAGTTCCACTGGTGCTGCTATGTCAAGTGCAACACGTGCAGCGAGCGCACGGAGATGTACACGTGCAAGTGAGCCCCGT
GTGCACACCACCCTCCCGCTGCAAGTCAGATTGCTGGGAGGACTGGACCGTTTCCAAGCTGCGGGCTCCCTGGCAGGATGCTGAGCTTGT
CTTTTCTGCTGAGGAGGGTACTTTTCCTGGGTTTCCTGCAGGCATCCGTGGGGGAAAAAAAATCTCTCAGAGCCCTCAACTATTCTGTTC
CACACCCAATGCTGCTCCACCCTCCCCCAGACACAGCCCAGGTCCCTCCGCGGCTGGAGCGAAGCCTTCTGCAGCAGGAACTCTGGACCC
CTGGGCCTCATCACAGCAATATTTAACAATTTATTCTGATAAAAATAATATTAATTTATTTAATTAAAAAGAATTCTTCCACCTCGTCGG
GATCCGTTTTCTGCAATCAAAGTGGACTGCTTGCTTTCCTAGCAGGATGATTTTGTTGCTAGGACAAGGAGCCGTGTAGAAGTGTACATA
ACTATTCTTTATGCAGATATTTCTACTAGCTGATTTTGCAGGTACCCACCTTGCAGCACTAGATGTTTAAGTACAAGAGGAGACATCTTT
TATGCATATATAGATATACACACACACATTTTTTTTTTTTTTTTTGCTGTTTGCTGCTACTTATCCAGAAATTTAAGCTGGTCCAGATTT
GGAGACGTTTTTTCCAGAGTATGTTTTCCATCCTTTTGCCCTCCCCAGTTCAAACTTCACCATTAGAAAAATCCAGTTTGGAATAAATAG
AGAGGAAAAATAATAAATTCCCAGCAGTTTCCATCTTTCGGAAAGTGAGCCACCGGATAAGAGAGAATATTTTGTAAGAGACTATTTTTA
TATGAATATTTTATTTATATCGAGTCTACTGTATCATTCCACGGCCTGTGCTTCTTCTTAATTCTGGTACTCACTTAGGGGTAAGGAGGG
GCGATGCCTGGTTGTGGCGTCAGGCCCCATGGGGCCCCTTGCACAGCTGGATTCTTGAGTTCTGTTTGCCAAGTGGGCACAAGCTGCCCC
TGGATGCCTGGGGTTGAGGCATCATCTCATCCATGTTAGCCGGGAAAGAAATCAAATCCCCAGCCTCAGCCTGTTAAGCTCAGGCCTTTC
AAGCAGGGCCACTGAGTGGTAGCTTCGAAATGAGTCACTGTGGTGGGTGGTCATCGTGCCCCTCACAGGGACTTGACCGTCATCCTGCAG
CAGAGGCCAGTTCAGGGAGCCCCACACCTCACCAAGACACTAGCCATTGCCTGCGTGTCCTGGAAGGTGAGATGTAGTCCTCAGGTGAGG
TGACCCAAAGCAGATGGGGTGAGGGGCCGATGAGCAGCCGGGCCCAGCGGGGCTTCCTGGATATCCTGCTCCCAAGGCCAAGCAGCAGAG
AGAGGTTCAAGTGAGGCCACTTTGCTTTGGGTCCAGCTACACCCAGAGCCTCAGCCTAGAAAGCTGTCCTCCAGCAGGCTGGGGGTGTTC
TAATATGTGTCCGTTTGCATTTCCGGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTACTGTATCTTCTTAGGG
ACTTGAGTGTAGTCACGTGACTTTGCGCCTTGCAGCGCCTCCGCCGTACTCGTGTGTGTATGTGTCTGTGTGTTTCCGTGCTACCCAAGC
GTCTGTTTCTCTCCGTGTGCCTGGGAGATCAGGTCTCAGGCATGGAGCTGCATGCCTTTGCATCTGCTGCTCCCCAGAGTCTCTGCTTGC
ATGTGAGGGCTGGTGGTATGAGGCAGACAGCAGAGATTGTGTGTGATTGTGTTGAACCGCCAAGAGAAGGCACCTCTGAACTCTGTCCCC
ACACCCATGGGTGAAAACCAGACACCTCTGAGACCACAGCACAGCCCCATGGCCCCACCTGCTGGGAGCCCTTCAGTATCTAGGCTGTGT
CTGACTCCTCAGTGTCCACACTGAGCCTGGATCACAGCATGGGCAAATAAAAGTGACTGGATGGTTGCATGGTTTCTTCCCTTGGACATT
TTTTTCCATTTTTCTTTTACTTGGGTGTCTGGAGGAGTGGGCATGTGAAGGGGCCATGGAGTGAATGGATGGAGGGATGGATGAATGTGT
GAGTAGGTAGGTAGGTGAATGGGTAGATGTGTGGATGGATAAGTAGGTGGGTGGGTGAATGGATAAATGGATGGATGGGTAGATGGATGG
ATGAAGGGATAAACAGATGGGTGGATGGATTGATAAGTGAGCGGATGAATGGATGAATAGCTAGGAAAGTGGGTGGGTGGATGAGGGTGG
GTTGATGAGGTAGGTACACCTACAGATAGGTAAGTGAGCAGTTTCTTGGGAGTCCACAGGTCACATTTTATCTTTGCTTTGGAAAACCTA
GCAGATCTGCCATGATCAGGATGGCTTCCCGACCTTGCAACCCTTCTGCTTCTGACCTCCTTGGCACCTGGGAATGGGGGAGATTCTGAC
CAGCCTCCCCAGATGAGTGTTCAATGATAGTTACATAAACACAGTCTCAGAAGAGTCATCCCTGTGTCCTCCCTCACTGTGGGTTCCCAG
CTCTGGGGCCTGCCCTCTCTCGGGTGCCCTGTTCAGCTGTGCTCTGAGCCCCAGTTTCTCCACCTGTGAAATCAGAATAACACCTACCTC

>81106_81106_2_SFMBT1-WNT7A_SFMBT1_chr3_53003117_ENST00000394752_WNT7A_chr3_13896300_ENST00000285018_length(amino acids)=272AA_BP=19
MFWEDIACLYAVEMNGEQQLDAGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFV
DAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKP
LSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYT

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SFMBT1-WNT7A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SFMBT1-WNT7A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SFMBT1-WNT7A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source