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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SFXN4-SIRT3 (FusionGDB2 ID:81226)

Fusion Gene Summary for SFXN4-SIRT3

Fusion gene summary

Fusion gene information	Fusion gene name: SFXN4-SIRT3
	Fusion gene ID: 81226
		Hgene	Tgene
	Gene symbol	SFXN4	SIRT3
	Gene ID	119559	23410
	Gene name	sideroflexin 4	sirtuin 3
	Synonyms	BCRM1\|COXPD18\|SLC56A4	SIR2L3
	Cytomap	10q26.11	11p15.5
	Type of gene	protein-coding	protein-coding
	Description	sideroflexin-4breast cancer resistance marker 1	NAD-dependent protein deacetylase sirtuin-3, mitochondrialNAD-dependent deacetylase sirtuin-3, mitochondrialSIR2-like protein 3mitochondrial nicotinamide adenine dinucleotide-dependent deacetylaseregulatory protein SIR2 homolog 3silent mating type in
	Modification date	20200313	20200329
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000330036, ENST00000355697, ENST00000461438,	ENST00000528702, ENST00000529382, ENST00000532956, ENST00000382743, ENST00000524564, ENST00000525319,
Fusion gene scores	* DoF score	1 X 1 X 1=1	7 X 5 X 5=175
	# samples	1	7
	** MAII score	log2(1/1*10)=3.32192809488736	log2(7/175*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SFXN4 [Title/Abstract] AND SIRT3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SFXN4(120925048)-SIRT3(224239), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SIRT3	GO:0006476	protein deacetylation	16788062
Tgene	SIRT3	GO:1901671	positive regulation of superoxide dismutase activity	25210848
Tgene	SIRT3	GO:1902553	positive regulation of catalase activity	25210848

Fusion gene breakpoints across SFXN4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SIRT3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SKCM	TCGA-GN-A26C	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-

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Fusion Gene ORF analysis for SFXN4-SIRT3

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000330036	ENST00000528702	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
5CDS-intron	ENST00000330036	ENST00000529382	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
5CDS-intron	ENST00000330036	ENST00000532956	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
5CDS-intron	ENST00000355697	ENST00000528702	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
5CDS-intron	ENST00000355697	ENST00000529382	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
5CDS-intron	ENST00000355697	ENST00000532956	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
5UTR-3CDS	ENST00000461438	ENST00000382743	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
5UTR-3CDS	ENST00000461438	ENST00000524564	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
5UTR-3CDS	ENST00000461438	ENST00000525319	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
5UTR-intron	ENST00000461438	ENST00000528702	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
5UTR-intron	ENST00000461438	ENST00000529382	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
5UTR-intron	ENST00000461438	ENST00000532956	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
In-frame	ENST00000330036	ENST00000382743	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
In-frame	ENST00000330036	ENST00000524564	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
In-frame	ENST00000330036	ENST00000525319	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
In-frame	ENST00000355697	ENST00000382743	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
In-frame	ENST00000355697	ENST00000524564	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-
In-frame	ENST00000355697	ENST00000525319	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000355697	SFXN4	chr10	120925048	-	ENST00000382743	SIRT3	chr11	224239	-	1764	131	20	523	167
ENST00000355697	SFXN4	chr10	120925048	-	ENST00000525319	SIRT3	chr11	224239	-	1016	131	20	523	167
ENST00000355697	SFXN4	chr10	120925048	-	ENST00000524564	SIRT3	chr11	224239	-	885	131	20	577	185
ENST00000330036	SFXN4	chr10	120925048	-	ENST00000382743	SIRT3	chr11	224239	-	1760	127	16	519	167
ENST00000330036	SFXN4	chr10	120925048	-	ENST00000525319	SIRT3	chr11	224239	-	1012	127	16	519	167
ENST00000330036	SFXN4	chr10	120925048	-	ENST00000524564	SIRT3	chr11	224239	-	881	127	16	573	185

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000355697	ENST00000382743	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-	0.035607878	0.9643922
ENST00000355697	ENST00000525319	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-	0.03717322	0.9628268
ENST00000355697	ENST00000524564	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-	0.05950751	0.9404925
ENST00000330036	ENST00000382743	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-	0.025534123	0.9744659
ENST00000330036	ENST00000525319	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-	0.029051391	0.97094864
ENST00000330036	ENST00000524564	SFXN4	chr10	120925048	-	SIRT3	chr11	224239	-	0.05106178	0.9489382

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Fusion Genomic Features for SFXN4-SIRT3

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SFXN4-SIRT3

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:120925048/chr11:224239)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SIRT3

chr10:120925048

chr11:224239

ENST00000529382

126_382

127

258.0

Domain

Deacetylase sirtuin-type

Tgene

SIRT3

chr10:120925048

chr11:224239

ENST00000382743

319_321

269

400.0

Nucleotide binding

NAD

Tgene

SIRT3

chr10:120925048

chr11:224239

ENST00000382743

344_346

269

400.0

Nucleotide binding

NAD

Tgene

SIRT3

chr10:120925048

chr11:224239

ENST00000529382

145_165

127

258.0

Nucleotide binding

NAD

Tgene

SIRT3

chr10:120925048

chr11:224239

ENST00000529382

228_231

127

258.0

Nucleotide binding

NAD

Tgene

SIRT3

chr10:120925048

chr11:224239

ENST00000529382

319_321

127

258.0

Nucleotide binding

NAD

Tgene

SIRT3

chr10:120925048

chr11:224239

ENST00000529382

344_346

127

258.0

Nucleotide binding

NAD

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SFXN4

chr10:120925048

chr11:224239

ENST00000355697

111_131

338.0

Transmembrane

Helical

Hgene

SFXN4

chr10:120925048

chr11:224239

ENST00000355697

133_153

338.0

Transmembrane

Helical

Hgene

SFXN4

chr10:120925048

chr11:224239

ENST00000355697

165_185

338.0

Transmembrane

Helical

Hgene

SFXN4

chr10:120925048

chr11:224239

ENST00000355697

251_271

338.0

Transmembrane

Helical

Hgene

SFXN4

chr10:120925048

chr11:224239

ENST00000355697

293_313

338.0

Transmembrane

Helical

Tgene

SIRT3

chr10:120925048

chr11:224239

ENST00000382743

126_382

269

400.0

Domain

Deacetylase sirtuin-type

Tgene

SIRT3

chr10:120925048

chr11:224239

ENST00000382743

145_165

269

400.0

Nucleotide binding

NAD

Tgene

SIRT3

chr10:120925048

chr11:224239

ENST00000382743

228_231

269

400.0

Nucleotide binding

NAD

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Fusion Gene Sequence for SFXN4-SIRT3

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>81226_81226_1_SFXN4-SIRT3_SFXN4_chr10_120925048_ENST00000330036_SIRT3_chr11_224239_ENST00000382743_length(transcript)=1760nt_BP=127nt
CTCTAACCAGCGCAAAATGTCCCTGGAACAGGAGGAGGAAACGCAACCTGGGCGGCTCCTAGGACGCAGAGACGCCGTCCCCGCCTTCAT
TGAGCCCAACGTGCGCTTCTGGATCACCGAGCGCCAAGCTGACGTGATGGCAGACAGGGTTCCCCGCTGCCCGGTCTGCACCGGCGTTGT
GAAGCCCGACATTGTGTTCTTTGGGGAGCCGCTGCCCCAGAGGTTCTTGCTGCATGTGGTTGATTTCCCCATGGCAGATCTGCTGCTCAT
CCTTGGGACCTCCCTGGAGGTGGAGCCTTTTGCCAGCTTGACCGAGGCCGTGCGGAGCTCAGTTCCCCGACTGCTCATCAACCGGGACTT
GGTGGGGCCCTTGGCTTGGCATCCTCGCAGCAGGGACGTGGCCCAGCTGGGGGACGTGGTTCACGGCGTGGAAAGCCTAGTGGAGCTTCT
GGGCTGGACAGAAGAGATGCGGGACCTTGTGCAGCGGGAAACTGGGAAGCTTGATGGACCAGACAAATAGGATGATGGCTGCCCCCACAC
AATAAATGGTAACATAGGAGACATCCACATCCCAATTCTGACAAGACCTCATGCCTGAAGACAGCTTGGGCAGGTGAAACCAGAATATGT
GAACTGAGTGGACACCCGAGGCTGCCACTGGAATGTCTTCTCAGGCCATGAGCTGCAGTGACTGGTAGGGCTGTGTTTACAGTCAGGGCC
ACCCCGTCACATATACAAAGGAGCTGCCTGCCTGTTTGCTGTGTTGAACTCTTCACTCTGCTGAAGCTCCTAATGGAAAAAGCTTTCTTC
TGACTGTGACCCTCTTGAACTGAATCAGACCAACTGGAATCCCAGACCGAGTCTGCTTTCTGTGCCTAGTTGAACGGCAAGCTCGGCATC
TGTTGGTTACAAGATCCAGACTTGGGCCGAGCGGTCCCCAGCCCTCTTCATGTTCCGAAGTGTAGTCTTGAGGCCCTGGTGCCGCACTTC
TAGCATGTTGGTCTCCTTTAGTGGGGCTATTTTTAATGAGAGAAAATCTGTTCTTTCCAGCATGAAATACATTTAGTCTCCTCAAAGGGA
CTGCAGGTGTTGACATGAGTTGGAAAGGGAACCCTGGGATACGTGGCGTCCCCTCTATTGGAACAGTCTGAGGACTGAAGGCATTTGTCC
CTGGATTTATTGGAGACGGCCCAGCTCCTCCCTCTGAAGGTGGTCACATTCTGTTGACTCTCCATACTCAGCCTCTCCTCCAGAAACAGA
TCTGTTCCAGAACATTCCAGCACTTTCTATCTGGCCTCCTTGTCCCCACACTACGCCCCCCCACCCTCGCCAGGGCTTCCTCTAGTGACA
CTGTTAGAGCTAATCTCTGAGACAGGGAAGGCATTACTCACTTAAAACCCAGGCTGAGTCCTGGCCACCTGCTGGATTGTGACATAGGAG
GTGGAATCCACTGAACTGCTACTTCTGCACAGGCTCCTTCTCCTGGGGCTGTACCCAGGCCCAGCCCTGATGGCTCACCCTGTCAGGCAC
CAGCTGCTCCCTCCTGGGCTCTCACCCACCTGCACATCCTCCTTCCTAGCATCACATTACCTGCGTGTTTCCCCAGACAAAAGCACTTCC
CATTCTTGAACCTTGCCTACCCTGGGCTGAGCTGACGGCAATAGATTTAATGACAGTGACTCCCAGGAAGGGGGTCCTGTGACTTTGCGC

>81226_81226_1_SFXN4-SIRT3_SFXN4_chr10_120925048_ENST00000330036_SIRT3_chr11_224239_ENST00000382743_length(amino acids)=167AA_BP=36
MSLEQEEETQPGRLLGRRDAVPAFIEPNVRFWITERQADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSL

--------------------------------------------------------------
>81226_81226_2_SFXN4-SIRT3_SFXN4_chr10_120925048_ENST00000330036_SIRT3_chr11_224239_ENST00000524564_length(transcript)=881nt_BP=127nt
CTCTAACCAGCGCAAAATGTCCCTGGAACAGGAGGAGGAAACGCAACCTGGGCGGCTCCTAGGACGCAGAGACGCCGTCCCCGCCTTCAT
TGAGCCCAACGTGCGCTTCTGGATCACCGAGCGCCAAGCTGACGTGATGGCAGACAGGGTTCCCCGCTGCCCGGTCTGCACCGGCGTTGT
GAAGCCCGACATTGTGTTCTTTGGGGAGCCGCTGCCCCAGAGGTTCTTGCTGCATGTGGTTGATTTCCCCATGGCAGATCTGCTGCTCAT
CCTTGGGACCTCCCTGGAGGTGGAGCCTTTTGCCAGCTTGACCGAGGCCGTGCGGAGCTCAGTTCCCCGACTGCTCATCAACCGGGACTT
GGTGGGGCCCTTGGCTTGGCATCCTCGCAGCAGGGACGTGGCCCAGCTGGGGGACGTGGTTCACGGCGTGGAAAGCCTAGTGGAGCTTCT
GGGCTGGACAGAAGAGATGCGGGACCTTGTGCAGCGGGAAACTGGGAAGGTACAGACTGCTGAGGAGGACCATCCAAGGGGCTGCCCTTC
TCACTGCTCTAGGCTTGATGGACCAGACAAATAGGATGATGGCTGCCCCCACACAATAAATGGTAACATAGGAGACATCCACATCCCAAT
TCTGACAAGACCTCATGCCTGAAGACAGCTTGGGCAGGTGAAACCAGAATATGTGAACTGAGTGGACACCCGAGGCTGCCACTGGAATGT
CTTCTCAGGCCATGAGCTGCAGTGACTGGTAGGGCTGTGTTTACAGTCAGGGCCACCCCGTCACATATACAAAGGAGCTGCCTGCCTGTT

>81226_81226_2_SFXN4-SIRT3_SFXN4_chr10_120925048_ENST00000330036_SIRT3_chr11_224239_ENST00000524564_length(amino acids)=185AA_BP=36
MSLEQEEETQPGRLLGRRDAVPAFIEPNVRFWITERQADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSL
EVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKVQTAEEDHPRGCPSHCSRL

--------------------------------------------------------------
>81226_81226_3_SFXN4-SIRT3_SFXN4_chr10_120925048_ENST00000330036_SIRT3_chr11_224239_ENST00000525319_length(transcript)=1012nt_BP=127nt
CTCTAACCAGCGCAAAATGTCCCTGGAACAGGAGGAGGAAACGCAACCTGGGCGGCTCCTAGGACGCAGAGACGCCGTCCCCGCCTTCAT
TGAGCCCAACGTGCGCTTCTGGATCACCGAGCGCCAAGCTGACGTGATGGCAGACAGGGTTCCCCGCTGCCCGGTCTGCACCGGCGTTGT
GAAGCCCGACATTGTGTTCTTTGGGGAGCCGCTGCCCCAGAGGTTCTTGCTGCATGTGGTTGATTTCCCCATGGCAGATCTGCTGCTCAT
CCTTGGGACCTCCCTGGAGGTGGAGCCTTTTGCCAGCTTGACCGAGGCCGTGCGGAGCTCAGTTCCCCGACTGCTCATCAACCGGGACTT
GGTGGGGCCCTTGGCTTGGCATCCTCGCAGCAGGGACGTGGCCCAGCTGGGGGACGTGGTTCACGGCGTGGAAAGCCTAGTGGAGCTTCT
GGGCTGGACAGAAGAGATGCGGGACCTTGTGCAGCGGGAAACTGGGAAGCTTGATGGACCAGACAAATAGGATGATGGCTGCCCCCACAC
AATAAATGGTAACATAGGAGACATCCACATCCCAATTCTGACAAGACCTCATGCCTGAAGACAGCTTGGGCAGGTGAAACCAGAATATGT
GAACTGAGTGGACACCCGAGGCTGCCACTGGAATGTCTTCTCAGGCCATGAGCTGCAGTGACTGGTAGGGCTGTGTTTACAGTCAGGGCC
ACCCCGTCACATATACAAAGGAGCTGCCTGCCTGTTTGCTGTGTTGAACTCTTCACTCTGCTGAAGCTCCTAATGGAAAAAGCTTTCTTC
TGACTGTGACCCTCTTGAACTGAATCAGACCAACTGGAATCCCAGACCGAGTCTGCTTTCTGTGCCTAGTTGAACGGCAAGCTCGGCATC
TGTTGGTTACAAGATCCAGACTTGGGCCGAGCGGTCCCCAGCCCTCTTCATGTTCCGAAGTGTAGTCTTGAGGCCCTGGTGCCGCACTTC

>81226_81226_3_SFXN4-SIRT3_SFXN4_chr10_120925048_ENST00000330036_SIRT3_chr11_224239_ENST00000525319_length(amino acids)=167AA_BP=36
MSLEQEEETQPGRLLGRRDAVPAFIEPNVRFWITERQADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSL

--------------------------------------------------------------
>81226_81226_4_SFXN4-SIRT3_SFXN4_chr10_120925048_ENST00000355697_SIRT3_chr11_224239_ENST00000382743_length(transcript)=1764nt_BP=131nt
GCCACTCTAACCAGCGCAAAATGTCCCTGGAACAGGAGGAGGAAACGCAACCTGGGCGGCTCCTAGGACGCAGAGACGCCGTCCCCGCCT
TCATTGAGCCCAACGTGCGCTTCTGGATCACCGAGCGCCAAGCTGACGTGATGGCAGACAGGGTTCCCCGCTGCCCGGTCTGCACCGGCG
TTGTGAAGCCCGACATTGTGTTCTTTGGGGAGCCGCTGCCCCAGAGGTTCTTGCTGCATGTGGTTGATTTCCCCATGGCAGATCTGCTGC
TCATCCTTGGGACCTCCCTGGAGGTGGAGCCTTTTGCCAGCTTGACCGAGGCCGTGCGGAGCTCAGTTCCCCGACTGCTCATCAACCGGG
ACTTGGTGGGGCCCTTGGCTTGGCATCCTCGCAGCAGGGACGTGGCCCAGCTGGGGGACGTGGTTCACGGCGTGGAAAGCCTAGTGGAGC
TTCTGGGCTGGACAGAAGAGATGCGGGACCTTGTGCAGCGGGAAACTGGGAAGCTTGATGGACCAGACAAATAGGATGATGGCTGCCCCC
ACACAATAAATGGTAACATAGGAGACATCCACATCCCAATTCTGACAAGACCTCATGCCTGAAGACAGCTTGGGCAGGTGAAACCAGAAT
ATGTGAACTGAGTGGACACCCGAGGCTGCCACTGGAATGTCTTCTCAGGCCATGAGCTGCAGTGACTGGTAGGGCTGTGTTTACAGTCAG
GGCCACCCCGTCACATATACAAAGGAGCTGCCTGCCTGTTTGCTGTGTTGAACTCTTCACTCTGCTGAAGCTCCTAATGGAAAAAGCTTT
CTTCTGACTGTGACCCTCTTGAACTGAATCAGACCAACTGGAATCCCAGACCGAGTCTGCTTTCTGTGCCTAGTTGAACGGCAAGCTCGG
CATCTGTTGGTTACAAGATCCAGACTTGGGCCGAGCGGTCCCCAGCCCTCTTCATGTTCCGAAGTGTAGTCTTGAGGCCCTGGTGCCGCA
CTTCTAGCATGTTGGTCTCCTTTAGTGGGGCTATTTTTAATGAGAGAAAATCTGTTCTTTCCAGCATGAAATACATTTAGTCTCCTCAAA
GGGACTGCAGGTGTTGACATGAGTTGGAAAGGGAACCCTGGGATACGTGGCGTCCCCTCTATTGGAACAGTCTGAGGACTGAAGGCATTT
GTCCCTGGATTTATTGGAGACGGCCCAGCTCCTCCCTCTGAAGGTGGTCACATTCTGTTGACTCTCCATACTCAGCCTCTCCTCCAGAAA
CAGATCTGTTCCAGAACATTCCAGCACTTTCTATCTGGCCTCCTTGTCCCCACACTACGCCCCCCCACCCTCGCCAGGGCTTCCTCTAGT
GACACTGTTAGAGCTAATCTCTGAGACAGGGAAGGCATTACTCACTTAAAACCCAGGCTGAGTCCTGGCCACCTGCTGGATTGTGACATA
GGAGGTGGAATCCACTGAACTGCTACTTCTGCACAGGCTCCTTCTCCTGGGGCTGTACCCAGGCCCAGCCCTGATGGCTCACCCTGTCAG
GCACCAGCTGCTCCCTCCTGGGCTCTCACCCACCTGCACATCCTCCTTCCTAGCATCACATTACCTGCGTGTTTCCCCAGACAAAAGCAC
TTCCCATTCTTGAACCTTGCCTACCCTGGGCTGAGCTGACGGCAATAGATTTAATGACAGTGACTCCCAGGAAGGGGGTCCTGTGACTTT

>81226_81226_4_SFXN4-SIRT3_SFXN4_chr10_120925048_ENST00000355697_SIRT3_chr11_224239_ENST00000382743_length(amino acids)=167AA_BP=36
MSLEQEEETQPGRLLGRRDAVPAFIEPNVRFWITERQADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSL

--------------------------------------------------------------
>81226_81226_5_SFXN4-SIRT3_SFXN4_chr10_120925048_ENST00000355697_SIRT3_chr11_224239_ENST00000524564_length(transcript)=885nt_BP=131nt
GCCACTCTAACCAGCGCAAAATGTCCCTGGAACAGGAGGAGGAAACGCAACCTGGGCGGCTCCTAGGACGCAGAGACGCCGTCCCCGCCT
TCATTGAGCCCAACGTGCGCTTCTGGATCACCGAGCGCCAAGCTGACGTGATGGCAGACAGGGTTCCCCGCTGCCCGGTCTGCACCGGCG
TTGTGAAGCCCGACATTGTGTTCTTTGGGGAGCCGCTGCCCCAGAGGTTCTTGCTGCATGTGGTTGATTTCCCCATGGCAGATCTGCTGC
TCATCCTTGGGACCTCCCTGGAGGTGGAGCCTTTTGCCAGCTTGACCGAGGCCGTGCGGAGCTCAGTTCCCCGACTGCTCATCAACCGGG
ACTTGGTGGGGCCCTTGGCTTGGCATCCTCGCAGCAGGGACGTGGCCCAGCTGGGGGACGTGGTTCACGGCGTGGAAAGCCTAGTGGAGC
TTCTGGGCTGGACAGAAGAGATGCGGGACCTTGTGCAGCGGGAAACTGGGAAGGTACAGACTGCTGAGGAGGACCATCCAAGGGGCTGCC
CTTCTCACTGCTCTAGGCTTGATGGACCAGACAAATAGGATGATGGCTGCCCCCACACAATAAATGGTAACATAGGAGACATCCACATCC
CAATTCTGACAAGACCTCATGCCTGAAGACAGCTTGGGCAGGTGAAACCAGAATATGTGAACTGAGTGGACACCCGAGGCTGCCACTGGA
ATGTCTTCTCAGGCCATGAGCTGCAGTGACTGGTAGGGCTGTGTTTACAGTCAGGGCCACCCCGTCACATATACAAAGGAGCTGCCTGCC

>81226_81226_5_SFXN4-SIRT3_SFXN4_chr10_120925048_ENST00000355697_SIRT3_chr11_224239_ENST00000524564_length(amino acids)=185AA_BP=36
MSLEQEEETQPGRLLGRRDAVPAFIEPNVRFWITERQADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSL
EVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKVQTAEEDHPRGCPSHCSRL

--------------------------------------------------------------
>81226_81226_6_SFXN4-SIRT3_SFXN4_chr10_120925048_ENST00000355697_SIRT3_chr11_224239_ENST00000525319_length(transcript)=1016nt_BP=131nt
GCCACTCTAACCAGCGCAAAATGTCCCTGGAACAGGAGGAGGAAACGCAACCTGGGCGGCTCCTAGGACGCAGAGACGCCGTCCCCGCCT
TCATTGAGCCCAACGTGCGCTTCTGGATCACCGAGCGCCAAGCTGACGTGATGGCAGACAGGGTTCCCCGCTGCCCGGTCTGCACCGGCG
TTGTGAAGCCCGACATTGTGTTCTTTGGGGAGCCGCTGCCCCAGAGGTTCTTGCTGCATGTGGTTGATTTCCCCATGGCAGATCTGCTGC
TCATCCTTGGGACCTCCCTGGAGGTGGAGCCTTTTGCCAGCTTGACCGAGGCCGTGCGGAGCTCAGTTCCCCGACTGCTCATCAACCGGG
ACTTGGTGGGGCCCTTGGCTTGGCATCCTCGCAGCAGGGACGTGGCCCAGCTGGGGGACGTGGTTCACGGCGTGGAAAGCCTAGTGGAGC
TTCTGGGCTGGACAGAAGAGATGCGGGACCTTGTGCAGCGGGAAACTGGGAAGCTTGATGGACCAGACAAATAGGATGATGGCTGCCCCC
ACACAATAAATGGTAACATAGGAGACATCCACATCCCAATTCTGACAAGACCTCATGCCTGAAGACAGCTTGGGCAGGTGAAACCAGAAT
ATGTGAACTGAGTGGACACCCGAGGCTGCCACTGGAATGTCTTCTCAGGCCATGAGCTGCAGTGACTGGTAGGGCTGTGTTTACAGTCAG
GGCCACCCCGTCACATATACAAAGGAGCTGCCTGCCTGTTTGCTGTGTTGAACTCTTCACTCTGCTGAAGCTCCTAATGGAAAAAGCTTT
CTTCTGACTGTGACCCTCTTGAACTGAATCAGACCAACTGGAATCCCAGACCGAGTCTGCTTTCTGTGCCTAGTTGAACGGCAAGCTCGG
CATCTGTTGGTTACAAGATCCAGACTTGGGCCGAGCGGTCCCCAGCCCTCTTCATGTTCCGAAGTGTAGTCTTGAGGCCCTGGTGCCGCA

>81226_81226_6_SFXN4-SIRT3_SFXN4_chr10_120925048_ENST00000355697_SIRT3_chr11_224239_ENST00000525319_length(amino acids)=167AA_BP=36
MSLEQEEETQPGRLLGRRDAVPAFIEPNVRFWITERQADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SFXN4-SIRT3

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SFXN4-SIRT3

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SFXN4-SIRT3

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source