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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SGPP2-SPATS2L (FusionGDB2 ID:81344)

Fusion Gene Summary for SGPP2-SPATS2L

check button Fusion gene summary
Fusion gene informationFusion gene name: SGPP2-SPATS2L
Fusion gene ID: 81344
HgeneTgene
Gene symbol

SGPP2

SPATS2L

Gene ID

130367

26010

Gene namesphingosine-1-phosphate phosphatase 2spermatogenesis associated serine rich 2 like
SynonymsSPP2|SPPase2DNAPTP6|SGNP
Cytomap

2q36.1

2q33.1

Type of geneprotein-codingprotein-coding
Descriptionsphingosine-1-phosphate phosphatase 2sphingosine 1-phosphate phosphohydrolase 2sphingosine-1-phosphatase 2sphingosine-1-phosphate phosphotase 2SPATS2-like proteinDNA polymerase-transactivated protein 6stress granule and nucleolar protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000321276, ENST00000360760, 
ENST00000409140, ENST00000409151, 
ENST00000409385, ENST00000409755, 
ENST00000451764, ENST00000460095, 
ENST00000358677, ENST00000409718, 
ENST00000409988, 
Fusion gene scores* DoF score12 X 7 X 6=50411 X 11 X 7=847
# samples 1313
** MAII scorelog2(13/504*10)=-1.95491211047146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/847*10)=-2.70385034630374
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SGPP2 [Title/Abstract] AND SPATS2L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSGPP2(223289540)-SPATS2L(201277033), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSGPP2

GO:0006670

sphingosine metabolic process

12411432


check buttonFusion gene breakpoints across SGPP2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SPATS2L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer5357NSGPP2chr2

223289540

+SPATS2Lchr2

201277033

+


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Fusion Gene ORF analysis for SGPP2-SPATS2L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000321276ENST00000360760SGPP2chr2

223289540

+SPATS2Lchr2

201277033

+
5CDS-5UTRENST00000321276ENST00000409140SGPP2chr2

223289540

+SPATS2Lchr2

201277033

+
5CDS-5UTRENST00000321276ENST00000409151SGPP2chr2

223289540

+SPATS2Lchr2

201277033

+
5CDS-5UTRENST00000321276ENST00000409385SGPP2chr2

223289540

+SPATS2Lchr2

201277033

+
5CDS-5UTRENST00000321276ENST00000409755SGPP2chr2

223289540

+SPATS2Lchr2

201277033

+
5CDS-5UTRENST00000321276ENST00000451764SGPP2chr2

223289540

+SPATS2Lchr2

201277033

+
5CDS-intronENST00000321276ENST00000460095SGPP2chr2

223289540

+SPATS2Lchr2

201277033

+
In-frameENST00000321276ENST00000358677SGPP2chr2

223289540

+SPATS2Lchr2

201277033

+
In-frameENST00000321276ENST00000409718SGPP2chr2

223289540

+SPATS2Lchr2

201277033

+
In-frameENST00000321276ENST00000409988SGPP2chr2

223289540

+SPATS2Lchr2

201277033

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000321276SGPP2chr2223289540+ENST00000409718SPATS2Lchr2201277033+2442305861942618
ENST00000321276SGPP2chr2223289540+ENST00000358677SPATS2Lchr2201277033+6175305861942618
ENST00000321276SGPP2chr2223289540+ENST00000409988SPATS2Lchr2201277033+2441305861942618

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000321276ENST00000409718SGPP2chr2223289540+SPATS2Lchr2201277033+0.0070403130.9929597
ENST00000321276ENST00000358677SGPP2chr2223289540+SPATS2Lchr2201277033+0.0009841910.9990158
ENST00000321276ENST00000409988SGPP2chr2223289540+SPATS2Lchr2201277033+0.0070161370.99298394

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Fusion Genomic Features for SGPP2-SPATS2L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SGPP2chr2223289540+SPATS2Lchr2201277033+1.11E-060.9999989
SGPP2chr2223289540+SPATS2Lchr2201277033+1.11E-060.9999989

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SGPP2-SPATS2L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:223289540/chr2:201277033)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSPATS2Lchr2:223289540chr2:201277033ENST00000358677213271_34413559.0Coiled coilOntology_term=ECO:0000255
TgeneSPATS2Lchr2:223289540chr2:201277033ENST00000360760212271_34413490.0Coiled coilOntology_term=ECO:0000255
TgeneSPATS2Lchr2:223289540chr2:201277033ENST00000409140213271_34413559.0Coiled coilOntology_term=ECO:0000255
TgeneSPATS2Lchr2:223289540chr2:201277033ENST00000409718213271_34413559.0Coiled coilOntology_term=ECO:0000255
TgeneSPATS2Lchr2:223289540chr2:201277033ENST00000409988213271_34413559.0Coiled coilOntology_term=ECO:0000255
TgeneSPATS2Lchr2:223289540chr2:201277033ENST00000451764314271_34413559.0Coiled coilOntology_term=ECO:0000255

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSGPP2chr2:223289540chr2:201277033ENST00000321276+15136_14473400.0RegionPhosphatase sequence motif I
HgeneSGPP2chr2:223289540chr2:201277033ENST00000321276+15163_16673400.0RegionPhosphatase sequence motif II
HgeneSGPP2chr2:223289540chr2:201277033ENST00000321276+15206_21773400.0RegionPhosphatase sequence motif III
HgeneSGPP2chr2:223289540chr2:201277033ENST00000321276+15121_14173400.0TransmembraneHelical
HgeneSGPP2chr2:223289540chr2:201277033ENST00000321276+15160_18073400.0TransmembraneHelical
HgeneSGPP2chr2:223289540chr2:201277033ENST00000321276+15185_20573400.0TransmembraneHelical
HgeneSGPP2chr2:223289540chr2:201277033ENST00000321276+15219_23973400.0TransmembraneHelical
HgeneSGPP2chr2:223289540chr2:201277033ENST00000321276+15247_26773400.0TransmembraneHelical
HgeneSGPP2chr2:223289540chr2:201277033ENST00000321276+15280_30073400.0TransmembraneHelical
HgeneSGPP2chr2:223289540chr2:201277033ENST00000321276+15318_33873400.0TransmembraneHelical
HgeneSGPP2chr2:223289540chr2:201277033ENST00000321276+15371_39173400.0TransmembraneHelical
HgeneSGPP2chr2:223289540chr2:201277033ENST00000321276+1588_10873400.0TransmembraneHelical


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Fusion Gene Sequence for SGPP2-SPATS2L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81344_81344_1_SGPP2-SPATS2L_SGPP2_chr2_223289540_ENST00000321276_SPATS2L_chr2_201277033_ENST00000358677_length(transcript)=6175nt_BP=305nt
GGCGGGGGCGAGGCGGGAGTGGCGGTGCCAGCGGAGGGCACCGGCCCGGCGTGGCAGCGGCGGCGGAGCGCGGCCCCGGGCACACCATGG
CCGAGCTGCTGCGGAGCCTGCAGGATTCCCAGCTCGTCGCCCGCTTCCAGCGCCGCTGCGGGCTCTTCCCCGCTCCGGATGAAGGCCCCC
GGGAGAACGGCGCGGACCCCACGGAGCGCGCGGCGCGGGTCCCCGGGGTCGAGCATCTCCCCGCAGCCAACGGCAAGGGCGGCGAGGCTC
CGGCCAACGGGCTGCGCAGAGCCGCGGCGCCGGAGATCTATGCAGTTAGATCAGTTGTTCCCAACAAAAGCAATAATGAAATAGTCCTGG
TGCTCCAACAGTTTGATTTTAATGTGGATAAAGCCGTGCAAGCCTTTGTGGATGGCAGTGCAATTCAAGTTCTAAAAGAATGGAATATGA
CAGGAAAAAAGAAGAACAATAAAAGAAAAAGAAGCAAGTCCAAGCAGCATCAAGGCAACAAAGATGCTAAAGACAAGGTGGAGAGGCCTG
AGGCAGGGCCCCTGCAGCCGCAGCCACCACAGATTCAAAACGGCCCCATGAATGGCTGCGAGAAGGACAGCTCGTCCACAGATTCTGCTA
ACGAAAAACCAGCCCTTATCCCTCGTGAGAAAAAGATCTCGATACTTGAGGAACCTTCAAAGGCACTTCGTGGGGTCACAGAAGGCAACA
GACTACTGCAACAGAAACTATCCTTAGATGGGAACCCCAAACCTATACATGGAACAACAGAGAGGTCAGATGGCCTACAGTGGTCAGCTG
AGCAGCCTTGTAACCCAAGCAAGCCTAAGGCAAAAACATCTCCTGTTAAGTCCAATACCCCTGCAGCTCATCTTGAAATAAAGCCAGATG
AGTTGGCAAAGAAAAGAGGCCCAAATATTGAGAAATCAGTGAAGGATTTGCAACGCTGCACCGTTTCTCTAACTAGATATCGCGTCATGA
TTAAGGAAGAAGTGGATAGTTCCGTGAAGAAGATCAAAGCTGCCTTTGCTGAATTACACAACTGCATCATTGACAAAGAAGTTTCATTAA
TGGCAGAAATGGATAAAGTTAAAGAAGAAGCCATGGAAATCCTGACTGCTCGTCAGAAGAAAGCAGAAGAACTAAAGAGACTCACTGACC
TTGCCAGTCAGATGGCAGAGATGCAGCTGGCCGAACTCAGGGCAGAAATTAAGCACTTTGTCAGCGAGCGTAAATATGACGAGGAGCTCG
GGAAAGCTGCCCGGTTTTCCTGTGACATCGAACAGCTGAAGGCCCAAATCATGCTCTGCGGAGAAATTACACATCCAAAGAACAACTATT
CCTCAAGAACTCCCTGCAGCTCCCTGCTGCCTCTGCTGAATGCGCACGCAGCAACCTCTGGGAAACAGAGTAACTTTTCCCGAAAATCAT
CCACTCACAATAAGCCCTCTGAAGGCAAAGCGGCAAACCCCAAAATGGTGAGCAGTCTCCCCAGCACCGCCGACCCCTCTCACCAGACCA
TGCCGGCCAACAAGCAGAATGGATCTTCTAACCAAAGACGGAGATTTAATCCACAGTATCATAACAACAGGCTAAATGGGCCTGCCAAGT
CGCAGGGCAGTGGGAATGAAGCCGAGCCACTGGGAAAGGGCAACAGCCGCCACGAACACAGAAGACAGCCGCACAACGGCTTCCGGCCCA
AAAACAAAGGCGGTGCCAAAAATCAAGAGGCTTCCTTGGGGATGAAGACCCCCGAGGCCCCGGCCCATTCTGAAAAGCCCCGGCGAAGGC
AGCACGCTGCAGACACCTCGGAGGCCAGGCCCTTCCGGGGTAGTGTCGGTAGGGTTTCACAGTGCAATCTCTGCCCCACGAGAATAGAAG
TTTCCACAGATGCAGCAGTTCTCTCAGTCCCGGCTGTGACGTTGGTGGCCTGAGCTAGGAGGAAAAAGAGCAGTTTTCACTCAGTTTTGG
TTCCCTGCCCGAGGTGCTGACCCAATTCGCTGCCAAAAGAGTGTCAATCAGAATATACAAATCCCGTATGGTTGTGTCATCCTCTCTTAA
TCATTTTTACTAATTCTAATAATCAGCTCTAGCTTGCTTCATAATTTTCATGGCTTTGCTTGATCTGTTGATGCTTTCTCTCATCAAGAC
TTTGCAGCATTTTAGCCAGGCAGTATTTACTCATTATTAGGAAAATCAAGATGTGGCTGAAGATCAGAGGCTCAGTTAGCAACCTGTGTT
GTAGCAGTGATGTCAGTCCATTGATTGTCTTTAGAGAGTTAATGTTACAAAAAAGAATTCTTAATAATCAGACAAACATGATCTGCTGAG
GACACATGCGCTTTTGTAGAATTTAACATCTGGTGTTTTTCTGAAAAAATATATATACATATATTGCTTTATTTGAAACAAATTAAAATA
TGCTGCATTTGACACCTGGCTAGTTTCTTTTATTGATACCCACCTAGTTATTGAATGTACTGTTTAGTGCTTTCAAAAAAAACTTTAGAG
ACTAGAGGTTGTGGTGCAAAGCTGTGTACAATAAATACTGTTTCTGTTGAGACAAGTACTCTTTCAGGAAAATATATATATGCCCTTTCA
ATTAGATTACACAAATAGATGGATATGCACCCTGATCATCTTAGACACACCATGTGGCAGTTGGGCAGTTGGAAACATTGGTTGCAAGTA
CTACAAACCTCAGCTGAGCCTAGCTTCAACAATAAGAATTTATTGGTTCAGTGAGTGAAAAGTCCAGTTGGTCCAATTTGATCAGGATTT
CAGCTCCCATCTCTTTTTTTTTTTTCTTTTTTCTTTTTCTTTTTTTGAGACAGTCTTGCTTTGTCACCCAGGTGGAGTGCAATGGCATGA
TCTCGGCTCACTGCAACCTCCGCCTCCTGGGTTCAAGCCATTCTCCTGCCCGGCCTTCCGAGTAGCTGGGATTACAGGCATGTGCCACCA
CGCCCTGCTAATTTTTATATTATTAGTACAGACAGGATTTCACCATGTTGTCCAGGCTGGTCTCAAACCCCTGACCTCAGGTGATCCACC
TGCTTTGGCCTCCGAAACTGCCGGAATTACAGGCATGAGCCACCGTACCCGGCCAGCTCCCATCTCTTAATTATCTTAGCTCTCCTTTCC
TCCTTGGGTTGACATTGCATTCAGAATTGTGGCAAAGGGCCACCATGCTCTTAAGACTCAAGTCTATTTTCCACACTGTCCAGAGGAGAG
AAGTTATCCTAGTAGCTTCTACACAGAGCAAGTGTCTTTCTCAGAAATCCCAGCAAAGGTCTTGCATACCATTGCTGGTAGGCCTGTCTC
TTAAACCAATCATGAAAGGGGGGAGAGAAGTGAATGGGATGAACTAATTTGCATAGACTAATTAGAGCCCACCCCTGGAGCCTGGGTGTG
GCCATCTTCCCAGAGTTCCTGAGCTAGATGGAGAAGGGGTACTTCTCAGAAAGGGAAAATGGATACCCAATGGCCCAAACCCAAAATAGC
CCCAGTTCCCCTAACTTTGACTACAGGGCAGTCCAGTTTGGGTGCCGCTTCCGTTGCACTCACATGTCCTACATATCTGTTGACTACTCA
CAAGTGCAAATGCTTATTCTCAACTCAACATTAACATTTTTTCTGGCAACCCAGGTTCACTGGTTCTCTTCCACAGAGCGGCCCTGAGCA
GCTGAGCCTGCAAGCCACGCAAGCATCTGTTTCTTCTTTTGCCAAGTACAGGAGGATGTTTGCTCTCTCTGTAGAGAGCTTTCTGAGGTC
TCTGGGTGTACCCAGAGATTTAATAGAAATTCTTAACGTTAAGTCACATTCCAGGAAGGAAGGAAGAGTTGTTCGTTCAAATAAGAAAGA
TAAATGTTCGGCACTGTAGGCCCTGTTTACCCCATCTGAGGCCCTGAATTCATATATTACAAGACGGAAGGATTTTGCACAGTTTTTTAT
GTAGCAAGATTTTGCTCACCACTGAAAAATGTCAGTGTAAATGTGACCGCTTTAAAGATGAGTCAAGTAATTCTTGGAACAGGGAAAAAA
ATGAATTTGCCAGGTCAGGAGTTCACCTGCCTTTGTCAGAGTTGAACCCAACCACTCTTGACCTCGACTCACTCCCTTAGGGTTAAGAAA
GCCCAAACACATTCCTGAGCACAGAGCAAACACTCCCATGTCACTGAAAAGAAACAAAAGAATGCTAAAAAGTGCTCAGACCTGATCACA
TTTTTTCCAATATTTTTTCCTTTTTTTTTTTTTTTTTGAGACAGGGTCTTGCTCTATCACCTAGGCTGGAGTGCATGTTTTTGAGACAGG
GTCTTGCTCTATCACCTAGGCTGGAGTGCATGATCATGGCTCACTATAGCCTTGAACTCCTGGGCTCAAGCCATCCTCAGCCTCCCAAGT
TGCGAGGACTACAGGTGTGCACCACAACGTCCCAGCTACTTTTTAAATTTTTAGTAGAAACGAGGTCTCACTATGGTGCCCAGACTGGTC
TCGAACTCCGGAGCTCAAGTGATCTTCCTGCTTTGGCCTCCCAAAGTGTTAGAATTACAGGCATGAGCCACCTCGCCTGGCTGGTTTTTG
CCTTTCTTATAGACCCTGGGCATGTAAGCATTTATTAGTTTGCATTTTTGAAACAGTAATTTCAATATTTTAGTGCCAATGTCAGGCCGC
TTAAACACTGTATTACATATCTTCATCTGTCTGGTGGAACTATTGGTGTGATCCTAGAGAACTGAGTCCTATTCTGCCATTCATTTAAAG
TGTTTTAAACTCTAATCTCTCTACTTAATGCACAGTAGTCAGATTATTCTCTTAAACATTTGCCTAGTAGAGGTTAAAATAGTTTAATCC
TTATGAAGATGGAATAACTTCAAACTCACATTGTGGCACTTAGATCTTCCACCAAGACTTCATCCGTGAAATCCACACCTCCCTGTTGGG
TTCCCAATTACATTCCAAATTTACATTTCTTTTGAGAATCTCTGCATACTCCAGCTCTGTCCTGTTGATCCTATTCTAGAAGTGCTTAAT
GCAGCAAGACACAGAAAGTTAAACGCAAATTGCTGCAAAATTCACCCTCAGTGGAGGACTAGAAACACAACATGTCCAATTTAAAGCTCA
GTTCACAAGCAGTTCAATTCTGCTGGCATCAGAAAAGGAGATTCTAATTAAACATTCTTAGGGAAGGACATCAAATGAGGTTAATGGGAA
ACGTTACCAGATTAAAAGCAGTTTTTTGACAAAGTAACAGATTTGGAAATTCTGACTCTCTGAAAGCCTTGATTTGAACCTCAAACTTGA
TTTCACCATGAGAAGTGGGGATCAAGGGCCTGCGCAGTTCTTTTCCTAAATCGATTCGGTGCTCCCCACCCCGACGCAGGCACAGGTCCG
CAACCAGATAGGGAGATGCCTGAATTTCAGGCTACCTTTGACAAAGCTTTCTTCCTCCCTCCCTCCCTTTGCACGCTGCATCCCACGCTG
CCTGCTTAAAGCGCCCTCATGTGTCTACAGATGGTAAAACGTTTATTTCTCAACAGACATTCCAGTGATAGCATCCAATGACCTATGTAA
CGGCACCCTTTTTTGCTGTACGCGTTTTTTGAGATGGAGTCTCGCTCTGTCGCCCAGGCTGGAGTGCAGTGGCGCGGTCTCGGCTCACTG
CAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGCACCCGCCACCACACCTGGCTAAT
TTTTTGTATTTTTAGTAGATACAGGGTTTCACCGTGTTAGCCAGGATGGTTTTGATCTCCTGACCTCGTGATCCACCCCCCTCGGCCTCC
CAAAGTGCTGGGATTACAGGGGTGAGCCACTGCGCCCGGCCCCAGTCACTTGTTCTTAAGTTTCTTAAGCAAACTATAAAATAGCAAAAG
ACCAAAAAAAAAGGAAAAAAAGCAGTTCGCCTAATACATTGTTCCAGCATTTCCTTGAAAGTACTGAGCCATCTCAATTGCTCTGATTTT
GTGAGAAAATTATGAAGAGTTGCAAAGTCCCAGTGATTCTCTTGTTACTTAGCTAAGAATTTGAAATGTAATTTAAATACTATTCTTTAC

>81344_81344_1_SGPP2-SPATS2L_SGPP2_chr2_223289540_ENST00000321276_SPATS2L_chr2_201277033_ENST00000358677_length(amino acids)=618AA_BP=73
MAELLRSLQDSQLVARFQRRCGLFPAPDEGPRENGADPTERAARVPGVEHLPAANGKGGEAPANGLRRAAAPEIYAVRSVVPNKSNNEIV
LVLQQFDFNVDKAVQAFVDGSAIQVLKEWNMTGKKKNNKRKRSKSKQHQGNKDAKDKVERPEAGPLQPQPPQIQNGPMNGCEKDSSSTDS
ANEKPALIPREKKISILEEPSKALRGVTEGNRLLQQKLSLDGNPKPIHGTTERSDGLQWSAEQPCNPSKPKAKTSPVKSNTPAAHLEIKP
DELAKKRGPNIEKSVKDLQRCTVSLTRYRVMIKEEVDSSVKKIKAAFAELHNCIIDKEVSLMAEMDKVKEEAMEILTARQKKAEELKRLT
DLASQMAEMQLAELRAEIKHFVSERKYDEELGKAARFSCDIEQLKAQIMLCGEITHPKNNYSSRTPCSSLLPLLNAHAATSGKQSNFSRK
SSTHNKPSEGKAANPKMVSSLPSTADPSHQTMPANKQNGSSNQRRRFNPQYHNNRLNGPAKSQGSGNEAEPLGKGNSRHEHRRQPHNGFR

--------------------------------------------------------------
>81344_81344_2_SGPP2-SPATS2L_SGPP2_chr2_223289540_ENST00000321276_SPATS2L_chr2_201277033_ENST00000409718_length(transcript)=2442nt_BP=305nt
GGCGGGGGCGAGGCGGGAGTGGCGGTGCCAGCGGAGGGCACCGGCCCGGCGTGGCAGCGGCGGCGGAGCGCGGCCCCGGGCACACCATGG
CCGAGCTGCTGCGGAGCCTGCAGGATTCCCAGCTCGTCGCCCGCTTCCAGCGCCGCTGCGGGCTCTTCCCCGCTCCGGATGAAGGCCCCC
GGGAGAACGGCGCGGACCCCACGGAGCGCGCGGCGCGGGTCCCCGGGGTCGAGCATCTCCCCGCAGCCAACGGCAAGGGCGGCGAGGCTC
CGGCCAACGGGCTGCGCAGAGCCGCGGCGCCGGAGATCTATGCAGTTAGATCAGTTGTTCCCAACAAAAGCAATAATGAAATAGTCCTGG
TGCTCCAACAGTTTGATTTTAATGTGGATAAAGCCGTGCAAGCCTTTGTGGATGGCAGTGCAATTCAAGTTCTAAAAGAATGGAATATGA
CAGGAAAAAAGAAGAACAATAAAAGAAAAAGAAGCAAGTCCAAGCAGCATCAAGGCAACAAAGATGCTAAAGACAAGGTGGAGAGGCCTG
AGGCAGGGCCCCTGCAGCCGCAGCCACCACAGATTCAAAACGGCCCCATGAATGGCTGCGAGAAGGACAGCTCGTCCACAGATTCTGCTA
ACGAAAAACCAGCCCTTATCCCTCGTGAGAAAAAGATCTCGATACTTGAGGAACCTTCAAAGGCACTTCGTGGGGTCACAGAAGGCAACA
GACTACTGCAACAGAAACTATCCTTAGATGGGAACCCCAAACCTATACATGGAACAACAGAGAGGTCAGATGGCCTACAGTGGTCAGCTG
AGCAGCCTTGTAACCCAAGCAAGCCTAAGGCAAAAACATCTCCTGTTAAGTCCAATACCCCTGCAGCTCATCTTGAAATAAAGCCAGATG
AGTTGGCAAAGAAAAGAGGCCCAAATATTGAGAAATCAGTGAAGGATTTGCAACGCTGCACCGTTTCTCTAACTAGATATCGCGTCATGA
TTAAGGAAGAAGTGGATAGTTCCGTGAAGAAGATCAAAGCTGCCTTTGCTGAATTACACAACTGCATCATTGACAAAGAAGTTTCATTAA
TGGCAGAAATGGATAAAGTTAAAGAAGAAGCCATGGAAATCCTGACTGCTCGTCAGAAGAAAGCAGAAGAACTAAAGAGACTCACTGACC
TTGCCAGTCAGATGGCAGAGATGCAGCTGGCCGAACTCAGGGCAGAAATTAAGCACTTTGTCAGCGAGCGTAAATATGACGAGGAGCTCG
GGAAAGCTGCCCGGTTTTCCTGTGACATCGAACAGCTGAAGGCCCAAATCATGCTCTGCGGAGAAATTACACATCCAAAGAACAACTATT
CCTCAAGAACTCCCTGCAGCTCCCTGCTGCCTCTGCTGAATGCGCACGCAGCAACCTCTGGGAAACAGAGTAACTTTTCCCGAAAATCAT
CCACTCACAATAAGCCCTCTGAAGGCAAAGCGGCAAACCCCAAAATGGTGAGCAGTCTCCCCAGCACCGCCGACCCCTCTCACCAGACCA
TGCCGGCCAACAAGCAGAATGGATCTTCTAACCAAAGACGGAGATTTAATCCACAGTATCATAACAACAGGCTAAATGGGCCTGCCAAGT
CGCAGGGCAGTGGGAATGAAGCCGAGCCACTGGGAAAGGGCAACAGCCGCCACGAACACAGAAGACAGCCGCACAACGGCTTCCGGCCCA
AAAACAAAGGCGGTGCCAAAAATCAAGAGGCTTCCTTGGGGATGAAGACCCCCGAGGCCCCGGCCCATTCTGAAAAGCCCCGGCGAAGGC
AGCACGCTGCAGACACCTCGGAGGCCAGGCCCTTCCGGGGTAGTGTCGGTAGGGTTTCACAGTGCAATCTCTGCCCCACGAGAATAGAAG
TTTCCACAGATGCAGCAGTTCTCTCAGTCCCGGCTGTGACGTTGGTGGCCTGAGCTAGGAGGAAAAAGAGCAGTTTTCACTCAGTTTTGG
TTCCCTGCCCGAGGTGCTGACCCAATTCGCTGCCAAAAGAGTGTCAATCAGAATATACAAATCCCGTATGGTTGTGTCATCCTCTCTTAA
TCATTTTTACTAATTCTAATAATCAGCTCTAGCTTGCTTCATAATTTTCATGGCTTTGCTTGATCTGTTGATGCTTTCTCTCATCAAGAC
TTTGCAGCATTTTAGCCAGGCAGTATTTACTCATTATTAGGAAAATCAAGATGTGGCTGAAGATCAGAGGCTCAGTTAGCAACCTGTGTT
GTAGCAGTGATGTCAGTCCATTGATTGTCTTTAGAGAGTTAATGTTACAAAAAAGAATTCTTAATAATCAGACAAACATGATCTGCTGAG
GACACATGCGCTTTTGTAGAATTTAACATCTGGTGTTTTTCTGAAAAAATATATATACATATATTGCTTTATTTGAAACAAATTAAAATA

>81344_81344_2_SGPP2-SPATS2L_SGPP2_chr2_223289540_ENST00000321276_SPATS2L_chr2_201277033_ENST00000409718_length(amino acids)=618AA_BP=73
MAELLRSLQDSQLVARFQRRCGLFPAPDEGPRENGADPTERAARVPGVEHLPAANGKGGEAPANGLRRAAAPEIYAVRSVVPNKSNNEIV
LVLQQFDFNVDKAVQAFVDGSAIQVLKEWNMTGKKKNNKRKRSKSKQHQGNKDAKDKVERPEAGPLQPQPPQIQNGPMNGCEKDSSSTDS
ANEKPALIPREKKISILEEPSKALRGVTEGNRLLQQKLSLDGNPKPIHGTTERSDGLQWSAEQPCNPSKPKAKTSPVKSNTPAAHLEIKP
DELAKKRGPNIEKSVKDLQRCTVSLTRYRVMIKEEVDSSVKKIKAAFAELHNCIIDKEVSLMAEMDKVKEEAMEILTARQKKAEELKRLT
DLASQMAEMQLAELRAEIKHFVSERKYDEELGKAARFSCDIEQLKAQIMLCGEITHPKNNYSSRTPCSSLLPLLNAHAATSGKQSNFSRK
SSTHNKPSEGKAANPKMVSSLPSTADPSHQTMPANKQNGSSNQRRRFNPQYHNNRLNGPAKSQGSGNEAEPLGKGNSRHEHRRQPHNGFR

--------------------------------------------------------------
>81344_81344_3_SGPP2-SPATS2L_SGPP2_chr2_223289540_ENST00000321276_SPATS2L_chr2_201277033_ENST00000409988_length(transcript)=2441nt_BP=305nt
GGCGGGGGCGAGGCGGGAGTGGCGGTGCCAGCGGAGGGCACCGGCCCGGCGTGGCAGCGGCGGCGGAGCGCGGCCCCGGGCACACCATGG
CCGAGCTGCTGCGGAGCCTGCAGGATTCCCAGCTCGTCGCCCGCTTCCAGCGCCGCTGCGGGCTCTTCCCCGCTCCGGATGAAGGCCCCC
GGGAGAACGGCGCGGACCCCACGGAGCGCGCGGCGCGGGTCCCCGGGGTCGAGCATCTCCCCGCAGCCAACGGCAAGGGCGGCGAGGCTC
CGGCCAACGGGCTGCGCAGAGCCGCGGCGCCGGAGATCTATGCAGTTAGATCAGTTGTTCCCAACAAAAGCAATAATGAAATAGTCCTGG
TGCTCCAACAGTTTGATTTTAATGTGGATAAAGCCGTGCAAGCCTTTGTGGATGGCAGTGCAATTCAAGTTCTAAAAGAATGGAATATGA
CAGGAAAAAAGAAGAACAATAAAAGAAAAAGAAGCAAGTCCAAGCAGCATCAAGGCAACAAAGATGCTAAAGACAAGGTGGAGAGGCCTG
AGGCAGGGCCCCTGCAGCCGCAGCCACCACAGATTCAAAACGGCCCCATGAATGGCTGCGAGAAGGACAGCTCGTCCACAGATTCTGCTA
ACGAAAAACCAGCCCTTATCCCTCGTGAGAAAAAGATCTCGATACTTGAGGAACCTTCAAAGGCACTTCGTGGGGTCACAGAAGGCAACA
GACTACTGCAACAGAAACTATCCTTAGATGGGAACCCCAAACCTATACATGGAACAACAGAGAGGTCAGATGGCCTACAGTGGTCAGCTG
AGCAGCCTTGTAACCCAAGCAAGCCTAAGGCAAAAACATCTCCTGTTAAGTCCAATACCCCTGCAGCTCATCTTGAAATAAAGCCAGATG
AGTTGGCAAAGAAAAGAGGCCCAAATATTGAGAAATCAGTGAAGGATTTGCAACGCTGCACCGTTTCTCTAACTAGATATCGCGTCATGA
TTAAGGAAGAAGTGGATAGTTCCGTGAAGAAGATCAAAGCTGCCTTTGCTGAATTACACAACTGCATCATTGACAAAGAAGTTTCATTAA
TGGCAGAAATGGATAAAGTTAAAGAAGAAGCCATGGAAATCCTGACTGCTCGTCAGAAGAAAGCAGAAGAACTAAAGAGACTCACTGACC
TTGCCAGTCAGATGGCAGAGATGCAGCTGGCCGAACTCAGGGCAGAAATTAAGCACTTTGTCAGCGAGCGTAAATATGACGAGGAGCTCG
GGAAAGCTGCCCGGTTTTCCTGTGACATCGAACAGCTGAAGGCCCAAATCATGCTCTGCGGAGAAATTACACATCCAAAGAACAACTATT
CCTCAAGAACTCCCTGCAGCTCCCTGCTGCCTCTGCTGAATGCGCACGCAGCAACCTCTGGGAAACAGAGTAACTTTTCCCGAAAATCAT
CCACTCACAATAAGCCCTCTGAAGGCAAAGCGGCAAACCCCAAAATGGTGAGCAGTCTCCCCAGCACCGCCGACCCCTCTCACCAGACCA
TGCCGGCCAACAAGCAGAATGGATCTTCTAACCAAAGACGGAGATTTAATCCACAGTATCATAACAACAGGCTAAATGGGCCTGCCAAGT
CGCAGGGCAGTGGGAATGAAGCCGAGCCACTGGGAAAGGGCAACAGCCGCCACGAACACAGAAGACAGCCGCACAACGGCTTCCGGCCCA
AAAACAAAGGCGGTGCCAAAAATCAAGAGGCTTCCTTGGGGATGAAGACCCCCGAGGCCCCGGCCCATTCTGAAAAGCCCCGGCGAAGGC
AGCACGCTGCAGACACCTCGGAGGCCAGGCCCTTCCGGGGTAGTGTCGGTAGGGTTTCACAGTGCAATCTCTGCCCCACGAGAATAGAAG
TTTCCACAGATGCAGCAGTTCTCTCAGTCCCGGCTGTGACGTTGGTGGCCTGAGCTAGGAGGAAAAAGAGCAGTTTTCACTCAGTTTTGG
TTCCCTGCCCGAGGTGCTGACCCAATTCGCTGCCAAAAGAGTGTCAATCAGAATATACAAATCCCGTATGGTTGTGTCATCCTCTCTTAA
TCATTTTTACTAATTCTAATAATCAGCTCTAGCTTGCTTCATAATTTTCATGGCTTTGCTTGATCTGTTGATGCTTTCTCTCATCAAGAC
TTTGCAGCATTTTAGCCAGGCAGTATTTACTCATTATTAGGAAAATCAAGATGTGGCTGAAGATCAGAGGCTCAGTTAGCAACCTGTGTT
GTAGCAGTGATGTCAGTCCATTGATTGTCTTTAGAGAGTTAATGTTACAAAAAAGAATTCTTAATAATCAGACAAACATGATCTGCTGAG
GACACATGCGCTTTTGTAGAATTTAACATCTGGTGTTTTTCTGAAAAAATATATATACATATATTGCTTTATTTGAAACAAATTAAAATA

>81344_81344_3_SGPP2-SPATS2L_SGPP2_chr2_223289540_ENST00000321276_SPATS2L_chr2_201277033_ENST00000409988_length(amino acids)=618AA_BP=73
MAELLRSLQDSQLVARFQRRCGLFPAPDEGPRENGADPTERAARVPGVEHLPAANGKGGEAPANGLRRAAAPEIYAVRSVVPNKSNNEIV
LVLQQFDFNVDKAVQAFVDGSAIQVLKEWNMTGKKKNNKRKRSKSKQHQGNKDAKDKVERPEAGPLQPQPPQIQNGPMNGCEKDSSSTDS
ANEKPALIPREKKISILEEPSKALRGVTEGNRLLQQKLSLDGNPKPIHGTTERSDGLQWSAEQPCNPSKPKAKTSPVKSNTPAAHLEIKP
DELAKKRGPNIEKSVKDLQRCTVSLTRYRVMIKEEVDSSVKKIKAAFAELHNCIIDKEVSLMAEMDKVKEEAMEILTARQKKAEELKRLT
DLASQMAEMQLAELRAEIKHFVSERKYDEELGKAARFSCDIEQLKAQIMLCGEITHPKNNYSSRTPCSSLLPLLNAHAATSGKQSNFSRK
SSTHNKPSEGKAANPKMVSSLPSTADPSHQTMPANKQNGSSNQRRRFNPQYHNNRLNGPAKSQGSGNEAEPLGKGNSRHEHRRQPHNGFR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SGPP2-SPATS2L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SGPP2-SPATS2L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SGPP2-SPATS2L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource