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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:ATP6V0E2-PPP2R5C (FusionGDB2 ID:8139)

Fusion Gene Summary for ATP6V0E2-PPP2R5C

Fusion gene summary

Fusion gene information	Fusion gene name: ATP6V0E2-PPP2R5C
	Fusion gene ID: 8139
		Hgene	Tgene
	Gene symbol	ATP6V0E2	PPP2R5C
	Gene ID	155066	5527
	Gene name	ATPase H+ transporting V0 subunit e2	protein phosphatase 2 regulatory subunit B'gamma
	Synonyms	ATP6V0E2L\|C7orf32	B56G\|B56gamma\|PR61G
	Cytomap	7q36.1	14q32.31
	Type of gene	protein-coding	protein-coding
	Description	V-type proton ATPase subunit e 2ATPase, H+ transporting V0 subunit E isoform 2-likeH+-ATPase e2 subunitV-ATPase subunit e 2lysosomal 9 kDa H(+)-transporting ATPase V0 subunit e2vacuolar proton pump subunit e 2vacuolar proton-ATPase subunit	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoformB' alpha regulatory subunitPP2A B subunit isoform B'-gammaPP2A B subunit isoform B56-gammaPP2A B subunit isoform PR61-gammaPP2A B subunit isoform R5-gammaprotein phosphat
	Modification date	20200313	20200313
	UniProtAcc	Q8NHE4	.
	Ensembl transtripts involved in fusion gene	ENST00000495408, ENST00000421974, ENST00000425642, ENST00000456496, ENST00000464662, ENST00000479613, ENST00000606024,	ENST00000422945, ENST00000328724, ENST00000554442, ENST00000556068, ENST00000334743, ENST00000350249, ENST00000445439, ENST00000556260, ENST00000556946, ENST00000557095, ENST00000557714,
Fusion gene scores	* DoF score	2 X 2 X 2=8	15 X 17 X 10=2550
	# samples	3	22
	** MAII score	log2(3/8*10)=1.90689059560852	log2(22/2550*10)=-3.53492181822156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: ATP6V0E2 [Title/Abstract] AND PPP2R5C [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	ATP6V0E2(149572734)-PPP2R5C(102229241), # samples:1 ATP6V0E2(149572734)-PPP2R5C(102229242), # samples:1
Anticipated loss of major functional domain due to fusion event.	ATP6V0E2-PPP2R5C seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. ATP6V0E2-PPP2R5C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. ATP6V0E2-PPP2R5C seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PPP2R5C	GO:0008285	negative regulation of cell proliferation	17245430

Fusion gene breakpoints across ATP6V0E2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PPP2R5C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-CD-8527-01A	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
ChimerDB4	STAD	TCGA-CD-8527	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+

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Fusion Gene ORF analysis for ATP6V0E2-PPP2R5C

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000495408	ENST00000422945	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
3UTR-3CDS	ENST00000495408	ENST00000422945	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
3UTR-3UTR	ENST00000495408	ENST00000328724	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
3UTR-3UTR	ENST00000495408	ENST00000328724	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
3UTR-3UTR	ENST00000495408	ENST00000554442	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
3UTR-3UTR	ENST00000495408	ENST00000554442	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
3UTR-3UTR	ENST00000495408	ENST00000556068	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
3UTR-3UTR	ENST00000495408	ENST00000556068	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
3UTR-intron	ENST00000495408	ENST00000334743	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
3UTR-intron	ENST00000495408	ENST00000334743	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
3UTR-intron	ENST00000495408	ENST00000350249	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
3UTR-intron	ENST00000495408	ENST00000350249	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
3UTR-intron	ENST00000495408	ENST00000445439	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
3UTR-intron	ENST00000495408	ENST00000445439	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
3UTR-intron	ENST00000495408	ENST00000556260	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
3UTR-intron	ENST00000495408	ENST00000556260	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
3UTR-intron	ENST00000495408	ENST00000556946	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
3UTR-intron	ENST00000495408	ENST00000556946	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
3UTR-intron	ENST00000495408	ENST00000557095	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
3UTR-intron	ENST00000495408	ENST00000557095	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
3UTR-intron	ENST00000495408	ENST00000557714	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
3UTR-intron	ENST00000495408	ENST00000557714	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000421974	ENST00000328724	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000421974	ENST00000328724	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000421974	ENST00000554442	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000421974	ENST00000554442	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000421974	ENST00000556068	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000421974	ENST00000556068	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000425642	ENST00000328724	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000425642	ENST00000328724	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000425642	ENST00000554442	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000425642	ENST00000554442	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000425642	ENST00000556068	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000425642	ENST00000556068	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000456496	ENST00000328724	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000456496	ENST00000328724	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000456496	ENST00000554442	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000456496	ENST00000554442	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000456496	ENST00000556068	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000456496	ENST00000556068	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000464662	ENST00000328724	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000464662	ENST00000328724	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000464662	ENST00000554442	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000464662	ENST00000554442	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000464662	ENST00000556068	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000464662	ENST00000556068	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000479613	ENST00000328724	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000479613	ENST00000328724	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000479613	ENST00000554442	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000479613	ENST00000554442	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000479613	ENST00000556068	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000479613	ENST00000556068	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000606024	ENST00000328724	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000606024	ENST00000328724	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000606024	ENST00000554442	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000606024	ENST00000554442	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-3UTR	ENST00000606024	ENST00000556068	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-3UTR	ENST00000606024	ENST00000556068	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000421974	ENST00000334743	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000421974	ENST00000334743	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000421974	ENST00000350249	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000421974	ENST00000350249	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000421974	ENST00000445439	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000421974	ENST00000445439	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000421974	ENST00000556260	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000421974	ENST00000556260	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000421974	ENST00000556946	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000421974	ENST00000556946	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000421974	ENST00000557095	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000421974	ENST00000557095	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000421974	ENST00000557714	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000421974	ENST00000557714	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000425642	ENST00000334743	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000425642	ENST00000334743	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000425642	ENST00000350249	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000425642	ENST00000350249	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000425642	ENST00000445439	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000425642	ENST00000445439	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000425642	ENST00000556260	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000425642	ENST00000556260	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000425642	ENST00000556946	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000425642	ENST00000556946	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000425642	ENST00000557095	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000425642	ENST00000557095	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000425642	ENST00000557714	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000425642	ENST00000557714	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000456496	ENST00000334743	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000456496	ENST00000334743	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000456496	ENST00000350249	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000456496	ENST00000350249	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000456496	ENST00000445439	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000456496	ENST00000445439	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000456496	ENST00000556260	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000456496	ENST00000556260	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000456496	ENST00000556946	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000456496	ENST00000556946	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000456496	ENST00000557095	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000456496	ENST00000557095	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000456496	ENST00000557714	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000456496	ENST00000557714	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000464662	ENST00000334743	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000464662	ENST00000334743	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000464662	ENST00000350249	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000464662	ENST00000350249	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000464662	ENST00000445439	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000464662	ENST00000445439	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000464662	ENST00000556260	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000464662	ENST00000556260	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000464662	ENST00000556946	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000464662	ENST00000556946	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000464662	ENST00000557095	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000464662	ENST00000557095	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000464662	ENST00000557714	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000464662	ENST00000557714	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000479613	ENST00000334743	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000479613	ENST00000334743	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000479613	ENST00000350249	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000479613	ENST00000350249	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000479613	ENST00000445439	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000479613	ENST00000445439	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000479613	ENST00000556260	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000479613	ENST00000556260	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000479613	ENST00000556946	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000479613	ENST00000556946	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000479613	ENST00000557095	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000479613	ENST00000557095	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000479613	ENST00000557714	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000479613	ENST00000557714	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000606024	ENST00000334743	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000606024	ENST00000334743	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000606024	ENST00000350249	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000606024	ENST00000350249	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000606024	ENST00000445439	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000606024	ENST00000445439	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000606024	ENST00000556260	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000606024	ENST00000556260	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000606024	ENST00000556946	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000606024	ENST00000556946	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000606024	ENST00000557095	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000606024	ENST00000557095	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
5CDS-intron	ENST00000606024	ENST00000557714	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
5CDS-intron	ENST00000606024	ENST00000557714	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
Frame-shift	ENST00000421974	ENST00000422945	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
Frame-shift	ENST00000421974	ENST00000422945	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
Frame-shift	ENST00000425642	ENST00000422945	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
Frame-shift	ENST00000425642	ENST00000422945	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
Frame-shift	ENST00000456496	ENST00000422945	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
Frame-shift	ENST00000456496	ENST00000422945	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
Frame-shift	ENST00000464662	ENST00000422945	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
Frame-shift	ENST00000464662	ENST00000422945	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
Frame-shift	ENST00000479613	ENST00000422945	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
Frame-shift	ENST00000479613	ENST00000422945	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+
Frame-shift	ENST00000606024	ENST00000422945	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229242	+
Frame-shift	ENST00000606024	ENST00000422945	ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Genomic Features for ATP6V0E2-PPP2R5C

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+	0.26229784	0.7377022
ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+	0.26229784	0.7377022
ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+	0.26229784	0.7377022
ATP6V0E2	chr7	149572734	+	PPP2R5C	chr14	102229241	+	0.26229784	0.7377022

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATP6V0E2-PPP2R5C

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:149572734/:102229241)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ATP6V0E2 Q8NHE4	.
FUNCTION: Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Gene Sequence for ATP6V0E2-PPP2R5C

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for ATP6V0E2-PPP2R5C

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for ATP6V0E2-PPP2R5C

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for ATP6V0E2-PPP2R5C

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source