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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SH3BGRL-DIAPH2 (FusionGDB2 ID:81405)

Fusion Gene Summary for SH3BGRL-DIAPH2

check button Fusion gene summary
Fusion gene informationFusion gene name: SH3BGRL-DIAPH2
Fusion gene ID: 81405
HgeneTgene
Gene symbol

SH3BGRL

DIAPH2

Gene ID

6451

1730

Gene nameSH3 domain binding glutamate rich protein likediaphanous related formin 2
SynonymsHEL-S-115|SH3BGRDIA|DIA2|DRF2|POF|POF2|POF2A
Cytomap

Xq21.1

Xq21.33

Type of geneprotein-codingprotein-coding
DescriptionSH3 domain-binding glutamic acid-rich-like proteinSH3 domain binding glutamic acid-rich protein likeSH3-binding domain glutamic acid-rich protein likeepididymis secretory protein Li 115protein diaphanous homolog 2diaphanous homolog 2diaphorase-2
Modification date2020031320200313
UniProtAcc.

Q14236

Ensembl transtripts involved in fusion geneENST00000481106, ENST00000373212, 
ENST00000324765, ENST00000355827, 
ENST00000373049, ENST00000373054, 
ENST00000373061, 
Fusion gene scores* DoF score4 X 4 X 3=4811 X 12 X 5=660
# samples 412
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/660*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SH3BGRL [Title/Abstract] AND DIAPH2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSH3BGRL(80457744)-DIAPH2(96354693), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SH3BGRL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DIAPH2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-CD-8525-01ASH3BGRLchrX

80457744

+DIAPH2chrX

96354693

+


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Fusion Gene ORF analysis for SH3BGRL-DIAPH2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000481106ENST00000324765SH3BGRLchrX

80457744

+DIAPH2chrX

96354693

+
3UTR-3CDSENST00000481106ENST00000355827SH3BGRLchrX

80457744

+DIAPH2chrX

96354693

+
3UTR-3CDSENST00000481106ENST00000373049SH3BGRLchrX

80457744

+DIAPH2chrX

96354693

+
3UTR-3CDSENST00000481106ENST00000373054SH3BGRLchrX

80457744

+DIAPH2chrX

96354693

+
3UTR-3CDSENST00000481106ENST00000373061SH3BGRLchrX

80457744

+DIAPH2chrX

96354693

+
In-frameENST00000373212ENST00000324765SH3BGRLchrX

80457744

+DIAPH2chrX

96354693

+
In-frameENST00000373212ENST00000355827SH3BGRLchrX

80457744

+DIAPH2chrX

96354693

+
In-frameENST00000373212ENST00000373049SH3BGRLchrX

80457744

+DIAPH2chrX

96354693

+
In-frameENST00000373212ENST00000373054SH3BGRLchrX

80457744

+DIAPH2chrX

96354693

+
In-frameENST00000373212ENST00000373061SH3BGRLchrX

80457744

+DIAPH2chrX

96354693

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373212SH3BGRLchrX80457744+ENST00000355827DIAPH2chrX96354693+14423031831346387
ENST00000373212SH3BGRLchrX80457744+ENST00000373054DIAPH2chrX96354693+13623031831361392
ENST00000373212SH3BGRLchrX80457744+ENST00000373061DIAPH2chrX96354693+26433031831361392
ENST00000373212SH3BGRLchrX80457744+ENST00000373049DIAPH2chrX96354693+14393031831346387
ENST00000373212SH3BGRLchrX80457744+ENST00000324765DIAPH2chrX96354693+70423031831361392

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373212ENST00000355827SH3BGRLchrX80457744+DIAPH2chrX96354693+0.0030576690.99694234
ENST00000373212ENST00000373054SH3BGRLchrX80457744+DIAPH2chrX96354693+0.0046412140.99535877
ENST00000373212ENST00000373061SH3BGRLchrX80457744+DIAPH2chrX96354693+0.0012414920.99875855
ENST00000373212ENST00000373049SH3BGRLchrX80457744+DIAPH2chrX96354693+0.0035590140.99644095
ENST00000373212ENST00000324765SH3BGRLchrX80457744+DIAPH2chrX96354693+0.0003781530.99962187

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Fusion Genomic Features for SH3BGRL-DIAPH2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SH3BGRLchrX80457744+DIAPH2chrX96354692+0.0001177410.9998822
SH3BGRLchrX80457744+DIAPH2chrX96354692+0.0001177410.9998822

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SH3BGRL-DIAPH2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:80457744/chrX:96354693)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DIAPH2

Q14236

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May function as an early signal that helps mediate the activation of T-cells. {ECO:0000269|PubMed:8133036}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003247651827903_10537491102.0Coiled coilOntology_term=ECO:0000255
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003730491827903_10537491097.0Coiled coilOntology_term=ECO:0000255
TgeneDIAPH2chrX:80457744chrX:96354693ENST0000032476518271038_10417491102.0Compositional biasNote=Poly-Lys
TgeneDIAPH2chrX:80457744chrX:96354693ENST0000032476518271072_10757491102.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneDIAPH2chrX:80457744chrX:96354693ENST0000037304918271038_10417491097.0Compositional biasNote=Poly-Lys
TgeneDIAPH2chrX:80457744chrX:96354693ENST0000037304918271072_10757491097.0Compositional biasNote=Arg/Lys-rich (basic)
TgeneDIAPH2chrX:80457744chrX:96354693ENST0000032476518271051_10817491102.0DomainDAD
TgeneDIAPH2chrX:80457744chrX:96354693ENST0000037304918271051_10817491097.0DomainDAD

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSH3BGRLchrX:80457744chrX:96354693ENST00000373212+1461_6715115.0MotifSH3-binding
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003247651827366_4187491102.0Coiled coilOntology_term=ECO:0000255
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003247651827487_5477491102.0Coiled coilOntology_term=ECO:0000255
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003730491827366_4187491097.0Coiled coilOntology_term=ECO:0000255
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003730491827487_5477491097.0Coiled coilOntology_term=ECO:0000255
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003247651827257_2607491102.0Compositional biasNote=Poly-Leu
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003247651827543_5467491102.0Compositional biasNote=Poly-Ser
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003247651827562_5727491102.0Compositional biasNote=Poly-Pro
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003247651827576_5857491102.0Compositional biasNote=Poly-Pro
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003247651827591_5977491102.0Compositional biasNote=Poly-Pro
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003247651827603_6087491102.0Compositional biasNote=Poly-Pro
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003247651827613_6167491102.0Compositional biasNote=Poly-Pro
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003730491827257_2607491097.0Compositional biasNote=Poly-Leu
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003730491827543_5467491097.0Compositional biasNote=Poly-Ser
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003730491827562_5727491097.0Compositional biasNote=Poly-Pro
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003730491827576_5857491097.0Compositional biasNote=Poly-Pro
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003730491827591_5977491097.0Compositional biasNote=Poly-Pro
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003730491827603_6087491097.0Compositional biasNote=Poly-Pro
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003730491827613_6167491097.0Compositional biasNote=Poly-Pro
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003247651827549_6237491102.0DomainNote=FH1
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003247651827628_10287491102.0DomainFH2
TgeneDIAPH2chrX:80457744chrX:96354693ENST00000324765182798_4647491102.0DomainGBD/FH3
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003730491827549_6237491097.0DomainNote=FH1
TgeneDIAPH2chrX:80457744chrX:96354693ENST000003730491827628_10287491097.0DomainFH2
TgeneDIAPH2chrX:80457744chrX:96354693ENST00000373049182798_4647491097.0DomainGBD/FH3


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Fusion Gene Sequence for SH3BGRL-DIAPH2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81405_81405_1_SH3BGRL-DIAPH2_SH3BGRL_chrX_80457744_ENST00000373212_DIAPH2_chrX_96354693_ENST00000324765_length(transcript)=7042nt_BP=303nt
CGAGATTCCCTATTAAAAAAAAATAGAATTGATGCAAACAGCCTGTTCCTTCCGGGGTTTTGGGCTGGAACTGCAGCGCTTAGAGAGCTC
GGTGGAAGCTGCTAAAGGCGGAGGCGGGGCTCTGGCGAGTTCTCCTTCCACCTTCCCCCACCCTTCTCTGCCAACCGCTGTTTCAGCCCC
TAGCTGGATTCCAGCCATTGCTGCAGCTGCTCCACAGCCCTTTTCAGGACCCAAACAACCGCAGCCGCTGTTCCCAGGATGGTGATCCGT
GTATATATTGCATCTTCCTCTGGCTCTACAGCGAACCTTGTGAAACATCTTCCTGAGCAGAAGATACTCAACGAATTAGCAGAGCTTAAG
AATGAATATGATGACCTCTGTGAGCCTGAACAATTTGGAGTTGTGATGAGCTCTGTGAAAATGTTACAGCCTCGTCTCAGTAGTATCCTG
TTCAAGCTCACATTTGAAGAACACATAAACAACATCAAACCAAGCATCATAGCAGTAACTCTTGCCTGTGAAGAACTGAAGAAAAGTGAA
AGCTTTAACAGACTTTTAGAGTTAGTTCTTCTTGTTGGAAACTACATGAACTCAGGCTCAAGAAATGCCCAGTCTTTGGGATTTAAGATC
AACTTCCTTTGTAAGATCAGAGATACTAAATCAGCGGATCAAAAAACAACCCTTTTGCATTTTATTGCCGACATTTGTGAGGAAAAATAT
CGAGATATCCTAAAATTTCCTGAAGAACTGGAACACGTAGAAAGTGCAAGCAAAGTTTCAGCTCAAATTCTCAAGAGCAACCTTGCATCA
ATGGAACAACAAATTGTTCATCTGGAACGTGACATCAAGAAATTCCCCCAAGCAGAAAATCAACACGATAAGTTTGTGGAAAAGATGACC
AGCTTTACAAAGACTGCCCGAGAACAGTATGAAAAACTCTCCACCATGCACAACAACATGATGAAGCTCTATGAGAATCTTGGAGAATAC
TTCATTTTTGACTCAAAGACAGTGAGCATAGAAGAGTTCTTTGGTGATCTCAACAACTTCCGAACTTTGTTTTTGGAAGCAGTGAGAGAA
AACAATAAGAGAAGAGAAATGGAAGAGAAGACCAGGAGGGCAAAACTTGCAAAAGAGAAAGCTGAACAAGAAAAGTTAGAACGCCAGAAG
AAAAAGAAACAACTCATTGATATAAACAAAGAGGGTGATGAGACTGGTGTGATGGATAATCTTCTAGAAGCCCTACAATCAGGTGCAGCA
TTCAGAGACCGTCGAAAGCGGATTCCAAGGAATCCAGATAACAGACGAGTACCTTTGGAAAGGTCACGCTCTCGCCACAATGGAGCTATC
TCATCTAAGTGATTCCTGATGCCAAAGAATATGAAAATATTTAAGTAAAAACAAAATGATGCATTTTGAGAAGAACAAAGTGTGCACTCA
GCGGCTGGAAAGGAAATAAGTGCATTTCTGCAAAGATCAAGATAAGCTGGATGAAGTAGTGTGCATTTGTAATACTATTGCAAGACTCCT
CCCACAATTATTCTAATCTGAACACAGTTATCAGGATTACAAAATGTGTTCCATTTTAGTGTAAAGATGTGTATCATTTGTAATTGTGTG
TGACCTGACTGTGATGATGGAAGTGTAAGAAATTGAAGAGTTCTAAGGCTTTCAAAAACACTCAGTCAAAAATTTAAAATCTTAAATGTG
TAAGTCACCCCCACCAAAAACAAAAGAGAAGAAAAAGAATAGAAAGAATTATCCAGTGTCAGCTTCCAATCCCTAGTACATATATAATAG
AAAAGGGCCAAGAAAAATATGCATCTTGATTTGGAGAGAGGCTAATATTATGCACACTGTAAGAGAAGCCATTTTGGAAATTCACGAAAG
TACTGCTCCACCCCAGTTGAGTTATTTAGAATTTTATCTCAAGTGAAAGCTGATGGATTCATCTGCTTTGGCTGAAATTAAACTTATCAT
TAGTCTAGCTAGCATTTCAGCATGATATTGCAAGCACTTCTCATTGCTAAAAATAAATAAACCAAAGTTTAACCGAATCAGTTAGGGAAA
GTGATTTAAACTTTATTTAAAGAGGTATTTTCTAATTATGCACAGATATCTACTTTATACAAATACTTTATATGGCTATTTTTGAGAAAA
CCCTCACATTTTAATGTTTATGCTAGGGATGAACCTGAAAATTCTATTACGTTTATTTAGATTTCAAAGGCAAATATTGATTCCTATGCT
CTGTGGTTTATTTCTTTTTTCTATTGCTTCTTTCTCCCTTGAGTCCCTTGAAGGCAGGGAATAGACTTCTAGAAAACCTGAGAGGAAAAA
GAATTCTTTTTACAGGAGGCAGCAGAAAACTGTCTGAAAGGTCAATTGTTTTATCTCCCTTTCCACTCTCTTTCCAATTTCACTTTGGTG
GTCTGAAGAAGAAAAAGAAATTTTATGTATGTATGTGTAAATATGTGTATATATTTCTATCTCTTGCTACAATAATTCCAACTAAGTGAA
CTTCTCAATTATCATCATACTTACTTACCTTATATTAACAAATTAAGATGATGCTGCCAAAACAAGTCTAGCAGGGAAAACAGGTTCTAC
ATTTTTCTTAAATAAATTAGGGAGTAAAAGTTATACTTAACTTGTCTGTCTATTATTTTAAAATATGCATTGAAATAATGTGGTATAACT
TCTCTGGAGTGCAATTTTAAGTCTAATTCATGCAGATGATTGATTGTGATTATTGTAAGAAATTTCTTACATGTATATTTCTTATGTAGA
AAATACTGTTTCTACTCATTCAAAGCACATTGTAGATATTCAGAGAGAAGAACAAATGGCTGGCTTGGCAAATCCCCATCTGAGATAAAG
TAAACAAGTGACCAGCAGCCCACAGATGATTCCTTTATATAGATGTATAATGATTCAAACTGCTGCCTTTGCCTCCAGTGCATCCTTACT
TAGGTATTATACTTCTTTAAAAAGCTCTGAAGCTGCTACAATAGAAAAATCAAAAAGGGTAACAGTATCTGAAATTTCACAGTCCTATCC
GATCTGAAAACACACATACACAAATGCACACACATGCACACACACATTTAAGGGACATAGCAGTAACACTGTTTTTTAACAACAACAAAA
GTTTAGGTTCTAATTTATGTAAATACCTAGTATGTGTATTTTTGACTTTACAAAGTCTTTCTTTTCTGAAATCTTCGTGGTATGGCTTTT
TTAATTCTTTTGACAGCTTATCAGTCTGTAGGAGAATGATCTTGAAATGTTAACCCTGACTAAAATTTGGGAGCATATGCCTTGCTATAT
TATCAAGCTGGTCAAGGTAGAAATACTGATATGTATCATCACCTTTTCCAGATACAAACTTGCCTTATTTTCTAGTTTGTGAACAAGAAC
GAATGAAGTACTATTATTGATAACTTATATATTTTTATTTAGAGCAATCCCACATGCTTTTCACAAACATTAAAAAAAAAAACCTTTCAG
GGTCTTTCATGAAGTTCCAATAGTTGAGTGAGTTAAAAGGTTTGTTTCCCAGATTTGTAATGGTCCTGCTCTAGCCATTTGCAGTTTTGT
TTTAGATGATTGGAAAGTATATCACCAAAAAAAGTATATAGTGACATTTTTAGTATGAAACCAAATTACACTAAGGTCTTTTGTTGGCCA
TATTACTGCCACACATGAGAAGCACCATTTATGCAGATTTTCTTCAGAATATTTTTAAAAGGTACAGAATCCTTAAAATATTAACAACTA
ATTGCATCCATCATCTCCTTTGGCTGCTGTAACAAATTACCACCAATAATATGATGGCTTAACACAACAGAAACTTATTTGCTTACATTT
TTGAAGGGCAGCAAAGCCATGCTCCCTCCAGAGGCTCTAGAGGAGAATCTTTCCTTGCCACGTCCACCTTTTGGTGGCTATTGGCATTTT
TTGGCTTATGGCCACATTTCTCTTTCTGCTGTGTCTTCACATCACCCTCCTCTGTATACCTAATCTGCCTCTGCCTCTGTTTAATAAGGA
TCCTTATGATGACTTTTAGGGACTACCCAGATTACTCCAGGATAATCTCCTCACCTCATGAGTCTTAACTTAATTACATCTGCAAGGCCC
CCTTCTCCAAATAAGATAAATTCATGGTTTTGGGGATTAGGATGTGGCTATGTCTTTTAGGAAGCCACTCTTAGCCCACCAGAGTCTGCC
CTTTGGCCCAAAATTTATGTCTGTCTCATGTGTAAAAGACATTCATCCCATCCTAACATTACCAAAAGTCTCAACCCATTATATCAATCC
TAAGTCCAAAATTTCATTCAAATATCATCGGTTCAAAAGTTCCAAAGCTTATCATTTAGATCATCTAAATCAGGTATGAGTGAAACTCTG
GGTATGGTCTTTCCTGAGGCCAAATTCCTCTTCCTCTGAGAACCAGTGAAACAGAAAAGTTAATCTGCTTTCAAATTACAATGGTGGGAA
CAGGCATAGGATAACAGTTACAGACATTTCTGTCTCAAAAAGGAGAGAATGGAAATTGGAATGGAGTCTCCTGTCCCAATCATTTTCAAA
ATCTAGCCAGGCAAATTTCTGTTATATTTCAAGGCCTGGCAGTAATCCTCTTTCTCAGGGCTCCACCCTTTGGGCCTGTAGCTCTTCTTT
CTTGGACTATGGATTGGGCCTCTGCCTCTGTGCCTATGGGTTGCACTTCTTCCTCTGTTCCCACACTTGGGCCTCTGCCTCTGTACCTGC
AGCTCTGCTCTCGGGATGGTGCTTCCTTTATCTTGAAGGGTGGCACATGTTTGCAGCTGAGAAGTTTTATCAACGGGTTTCCTACCTGTA
GAATTCTGGCAGTCTCACAATCTTCTTTCATTTTTTTCTGTCTCTGTCCCTTTTAGGCCCAGTTGGAAGTGTTTCTGATGGTAGAACATT
CTCAAAAATCTTGTGGGTCTTCTACGTATGTCACATTGATTCACACATTCAGAAAAGAGGGTCCTCACAGATTTTTCCTGAACAACCCCA
TCTCTATTCTTGGCTTCTGTTGAAACAGTCAAATAAATCCACAAGTTAATGCCTAACCTCTTCAGCACTAGCCAAAGGTTGTCAAGACAC
ACCCTTGGGCTTATCTACAGAGCACACTTTTCTAACAGTGAATCTCCTAATTTTAGCATCTTTTTTTTTTTTTACAATCATTCAGATTGT
GAATTCAGGCTCAGAATTTACCCAGTCATCAGATACTGATTCCTTTTGTCCACTTATATAGTTATTTTCTCTTTAAAAAAAAATTTTTTT
TAATGTATTAGAGATGAGGTCTCACTCTGTCACCCAGGCTGCAGTGTAGTGGTGCAAACATAGCTCCCTGTAACCTCAAACTCCCAGGCT
CAAGGGATCCTCCTGCATCAGCCTTCCAAGTAGCTGGGTCTACAGGTGCATGCCACCATGCCTGGCTAATTTTTTGCATTTTTTTGTAGA
GACTTGATCTTGCTATGTTGTCCAGGCTGCTCTCGAACTCCTAGCCTCAAGCAATCCACCCATCTTGGCCTCCTAAAGTGCCGGATTACA
GGTGTAAGCCACCATGCCCAGCCTGTTTTGTCAATGTATCTGTTTTCTGTCTTATTTTACTATAAGCACTAAGAAGAAACTAAGCTATAT
CTCTAACACTAGACTTGAAAATTTCCTCAGCTAAACATCCAAGTTCATCATTTATTCAACTTTTCACACTACTGTAGTAGACAATTTAGA
TAGATAAACTTTTTGCCACTATATGACAAGGATTCCCTTTCTTCCATTTTCCAATAAAATCTTCATTTCCTTCTAAACCATCACTAGAAA
TGCCTTTAACATTCATACTACTACCATCTGGTAAAGGCAATCTAGTTTTTTCTATCACAGCCACCAAAATTCTTCTAGTCTCTACCCATT
ATCCAATTCCAAAGCCTTTTTCACATTTTAAGACATTTGTTACAGAAGTACCCAATCCGTCCCAGTTCCACAATCTGCATTAGATTCCCA
TGGCTGCTGTAACAAATTACCCTCTAGCCCAGTGGCTTAAAACAATAGAAATTTATTATCTTGTTGTTTTGGAGGCCAAAAGTCCAAAAT
TGAGGGGTTGGCAGGGCTGAACGTCTTCTGGAGACTCTAAGGGAAACACTCTTCCCGTGTCTTCCAGTTTCTTGTGGCTGCCATCATTCC
TTGGTTTGTGACTGCATCTCCCTCTCCTCTGTCTTCACATCACTTCCCCTCTGTATATATAATCTACCTCTGCCTCTCTCTTATAAGGAC
ACTTGTGACGGGACTTAGGGCCCATCCAGATTACCCATGATAATTCCCTTATTCCAAGATTCTTAATTATATCTGAAAGGACCTTTTTTC
CAAATAAGGTACTATCACAGGTTCCAGGGAGTAGGATATTGAATATCTTTTTTGGGGAGGGGGCACCATGCAGCTCACTACACTATTCAT
TGCACACAAATGAATTTTTCACTTTTTAAGATGCATTCTTGGTGCTCAAACCAGATCGAAGTTTGTCTCTAAAAGCTATTGTCTGCACAG
GCTGCTGCATGCTCTGTTGTTAAATGGATGGACAGGCTATTCTAAATTTTGGTTGATACTTTTGCTACTATGGGCAATTAACTTGAAAAA
AATAATCGATCCCAACTCTGTGCTCTGATGTACCTCTTCTGCCCCTTTTATGACACCTTTGACCAAATGCCTTCTATGGTTCACAGTGCA
GGCACAAAACTACCTCTGATACAGAAGGGTTCTTTACAAGCTTATTTTACATACCGTGAATCCCTCACCTAAAGGGAGAGGTGAAAGCAA
AGACTGCTTTGAATGGGTATTGAGGGAGATTGTGTCCATACCAAGCCACCCTGAAGAAGTATTTCACTTGCAGTAGAACTGTGGATTTGT
GCTGTCATTTCACCTTGGAATAAACACCTATCTCTAAGCAGGACCAAGAATGACTTGCAATCTATATGTAATGGCTACTTACTTATTCAA

>81405_81405_1_SH3BGRL-DIAPH2_SH3BGRL_chrX_80457744_ENST00000373212_DIAPH2_chrX_96354693_ENST00000324765_length(amino acids)=392AA_BP=40
MDSSHCCSCSTALFRTQTTAAAVPRMVIRVYIASSSGSTANLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILF
KLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYR
DILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGEYF
IFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAF

--------------------------------------------------------------
>81405_81405_2_SH3BGRL-DIAPH2_SH3BGRL_chrX_80457744_ENST00000373212_DIAPH2_chrX_96354693_ENST00000355827_length(transcript)=1442nt_BP=303nt
CGAGATTCCCTATTAAAAAAAAATAGAATTGATGCAAACAGCCTGTTCCTTCCGGGGTTTTGGGCTGGAACTGCAGCGCTTAGAGAGCTC
GGTGGAAGCTGCTAAAGGCGGAGGCGGGGCTCTGGCGAGTTCTCCTTCCACCTTCCCCCACCCTTCTCTGCCAACCGCTGTTTCAGCCCC
TAGCTGGATTCCAGCCATTGCTGCAGCTGCTCCACAGCCCTTTTCAGGACCCAAACAACCGCAGCCGCTGTTCCCAGGATGGTGATCCGT
GTATATATTGCATCTTCCTCTGGCTCTACAGCGAACCTTGTGAAACATCTTCCTGAGCAGAAGATACTCAACGAATTAGCAGAGCTTAAG
AATGAATATGATGACCTCTGTGAGCCTGAACAATTTGGAGTTGTGATGAGCTCTGTGAAAATGTTACAGCCTCGTCTCAGTAGTATCCTG
TTCAAGCTCACATTTGAAGAACACATAAACAACATCAAACCAAGCATCATAGCAGTAACTCTTGCCTGTGAAGAACTGAAGAAAAGTGAA
AGCTTTAACAGACTTTTAGAGTTAGTTCTTCTTGTTGGAAACTACATGAACTCAGGCTCAAGAAATGCCCAGTCTTTGGGATTTAAGATC
AACTTCCTTTGTAAGATCAGAGATACTAAATCAGCGGATCAAAAAACAACCCTTTTGCATTTTATTGCCGACATTTGTGAGGAAAAATAT
CGAGATATCCTAAAATTTCCTGAAGAACTGGAACACGTAGAAAGTGCAAGCAAAGTTTCAGCTCAAATTCTCAAGAGCAACCTTGCATCA
ATGGAACAACAAATTGTTCATCTGGAACGTGACATCAAGAAATTCCCCCAAGCAGAAAATCAACACGATAAGTTTGTGGAAAAGATGACC
ATCTTTACAAAGACTGCCCGAGAACAGTATGAAAAACTCTCCACCATGCACAACAACATGATGAAGCTCTATGAGAATCTTGGAGAATAC
TTCATTTTTGACTCAAAGACAGTGAGCATAGAAGAGTTCTTTGGTGATCTCAACAACTTCCGAACTTTGTTTTTGGAAGCAGTGAGAGAA
AACAATAAGAGAAGAGAAATGGAAGAGAAGACCAGGAGGGCAAAACTTGCAAAAGAGAAAGCTGAACAAGAAAAGTTAGAACGCCAGAAG
AAAAAGAAACAACTCATTGATATAAACAAAGAGGGTGATGAGACTGGTGTGATGGATAATCTTCTAGAAGCCCTACAATCAGGTGCAGCA
TTCAGAGACCGTCGAAAGCGGATTCCAAGGAATCCAGTGGTAAATCATCCCTGTGCAACAAGGGCTAATCCAAGATCAGCTACATAAACG
GCCTGAGTGCTGTTTTAAACAGGATTGGGTGATGGTACAACATGACTTTTTAAGATAATCAAGTAGTAAAAGTTTCTAGTGGAAACATGA

>81405_81405_2_SH3BGRL-DIAPH2_SH3BGRL_chrX_80457744_ENST00000373212_DIAPH2_chrX_96354693_ENST00000355827_length(amino acids)=387AA_BP=40
MDSSHCCSCSTALFRTQTTAAAVPRMVIRVYIASSSGSTANLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILF
KLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYR
DILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTIFTKTAREQYEKLSTMHNNMMKLYENLGEYF
IFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAF

--------------------------------------------------------------
>81405_81405_3_SH3BGRL-DIAPH2_SH3BGRL_chrX_80457744_ENST00000373212_DIAPH2_chrX_96354693_ENST00000373049_length(transcript)=1439nt_BP=303nt
CGAGATTCCCTATTAAAAAAAAATAGAATTGATGCAAACAGCCTGTTCCTTCCGGGGTTTTGGGCTGGAACTGCAGCGCTTAGAGAGCTC
GGTGGAAGCTGCTAAAGGCGGAGGCGGGGCTCTGGCGAGTTCTCCTTCCACCTTCCCCCACCCTTCTCTGCCAACCGCTGTTTCAGCCCC
TAGCTGGATTCCAGCCATTGCTGCAGCTGCTCCACAGCCCTTTTCAGGACCCAAACAACCGCAGCCGCTGTTCCCAGGATGGTGATCCGT
GTATATATTGCATCTTCCTCTGGCTCTACAGCGAACCTTGTGAAACATCTTCCTGAGCAGAAGATACTCAACGAATTAGCAGAGCTTAAG
AATGAATATGATGACCTCTGTGAGCCTGAACAATTTGGAGTTGTGATGAGCTCTGTGAAAATGTTACAGCCTCGTCTCAGTAGTATCCTG
TTCAAGCTCACATTTGAAGAACACATAAACAACATCAAACCAAGCATCATAGCAGTAACTCTTGCCTGTGAAGAACTGAAGAAAAGTGAA
AGCTTTAACAGACTTTTAGAGTTAGTTCTTCTTGTTGGAAACTACATGAACTCAGGCTCAAGAAATGCCCAGTCTTTGGGATTTAAGATC
AACTTCCTTTGTAAGATCAGAGATACTAAATCAGCGGATCAAAAAACAACCCTTTTGCATTTTATTGCCGACATTTGTGAGGAAAAATAT
CGAGATATCCTAAAATTTCCTGAAGAACTGGAACACGTAGAAAGTGCAAGCAAAGTTTCAGCTCAAATTCTCAAGAGCAACCTTGCATCA
ATGGAACAACAAATTGTTCATCTGGAACGTGACATCAAGAAATTCCCCCAAGCAGAAAATCAACACGATAAGTTTGTGGAAAAGATGACC
AGCTTTACAAAGACTGCCCGAGAACAGTATGAAAAACTCTCCACCATGCACAACAACATGATGAAGCTCTATGAGAATCTTGGAGAATAC
TTCATTTTTGACTCAAAGACAGTGAGCATAGAAGAGTTCTTTGGTGATCTCAACAACTTCCGAACTTTGTTTTTGGAAGCAGTGAGAGAA
AACAATAAGAGAAGAGAAATGGAAGAGAAGACCAGGAGGGCAAAACTTGCAAAAGAGAAAGCTGAACAAGAAAAGTTAGAACGCCAGAAG
AAAAAGAAACAACTCATTGATATAAACAAAGAGGGTGATGAGACTGGTGTGATGGATAATCTTCTAGAAGCCCTACAATCAGGTGCAGCA
TTCAGAGACCGTCGAAAGCGGATTCCAAGGAATCCAGTGGTAAATCATCCCTGTGCAACAAGGGCTAATCCAAGATCAGCTACATAAACG

>81405_81405_3_SH3BGRL-DIAPH2_SH3BGRL_chrX_80457744_ENST00000373212_DIAPH2_chrX_96354693_ENST00000373049_length(amino acids)=387AA_BP=40
MDSSHCCSCSTALFRTQTTAAAVPRMVIRVYIASSSGSTANLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILF
KLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYR
DILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTSFTKTAREQYEKLSTMHNNMMKLYENLGEYF
IFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAF

--------------------------------------------------------------
>81405_81405_4_SH3BGRL-DIAPH2_SH3BGRL_chrX_80457744_ENST00000373212_DIAPH2_chrX_96354693_ENST00000373054_length(transcript)=1362nt_BP=303nt
CGAGATTCCCTATTAAAAAAAAATAGAATTGATGCAAACAGCCTGTTCCTTCCGGGGTTTTGGGCTGGAACTGCAGCGCTTAGAGAGCTC
GGTGGAAGCTGCTAAAGGCGGAGGCGGGGCTCTGGCGAGTTCTCCTTCCACCTTCCCCCACCCTTCTCTGCCAACCGCTGTTTCAGCCCC
TAGCTGGATTCCAGCCATTGCTGCAGCTGCTCCACAGCCCTTTTCAGGACCCAAACAACCGCAGCCGCTGTTCCCAGGATGGTGATCCGT
GTATATATTGCATCTTCCTCTGGCTCTACAGCGAACCTTGTGAAACATCTTCCTGAGCAGAAGATACTCAACGAATTAGCAGAGCTTAAG
AATGAATATGATGACCTCTGTGAGCCTGAACAATTTGGAGTTGTGATGAGCTCTGTGAAAATGTTACAGCCTCGTCTCAGTAGTATCCTG
TTCAAGCTCACATTTGAAGAACACATAAACAACATCAAACCAAGCATCATAGCAGTAACTCTTGCCTGTGAAGAACTGAAGAAAAGTGAA
AGCTTTAACAGACTTTTAGAGTTAGTTCTTCTTGTTGGAAACTACATGAACTCAGGCTCAAGAAATGCCCAGTCTTTGGGATTTAAGATC
AACTTCCTTTGTAAGATCAGAGATACTAAATCAGCGGATCAAAAAACAACCCTTTTGCATTTTATTGCCGACATTTGTGAGGAAAAATAT
CGAGATATCCTAAAATTTCCTGAAGAACTGGAACACGTAGAAAGTGCAAGCAAAGTTTCAGCTCAAATTCTCAAGAGCAACCTTGCATCA
ATGGAACAACAAATTGTTCATCTGGAACGTGACATCAAGAAATTCCCCCAAGCAGAAAATCAACACGATAAGTTTGTGGAAAAGATGACC
ATCTTTACAAAGACTGCCCGAGAACAGTATGAAAAACTCTCCACCATGCACAACAACATGATGAAGCTCTATGAGAATCTTGGAGAATAC
TTCATTTTTGACTCAAAGACAGTGAGCATAGAAGAGTTCTTTGGTGATCTCAACAACTTCCGAACTTTGTTTTTGGAAGCAGTGAGAGAA
AACAATAAGAGAAGAGAAATGGAAGAGAAGACCAGGAGGGCAAAACTTGCAAAAGAGAAAGCTGAACAAGAAAAGTTAGAACGCCAGAAG
AAAAAGAAACAACTCATTGATATAAACAAAGAGGGTGATGAGACTGGTGTGATGGATAATCTTCTAGAAGCCCTACAATCAGGTGCAGCA
TTCAGAGACCGTCGAAAGCGGATTCCAAGGAATCCAGATAACAGACGAGTACCTTTGGAAAGGTCACGCTCTCGCCACAATGGAGCTATC

>81405_81405_4_SH3BGRL-DIAPH2_SH3BGRL_chrX_80457744_ENST00000373212_DIAPH2_chrX_96354693_ENST00000373054_length(amino acids)=392AA_BP=40
MDSSHCCSCSTALFRTQTTAAAVPRMVIRVYIASSSGSTANLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILF
KLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYR
DILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTIFTKTAREQYEKLSTMHNNMMKLYENLGEYF
IFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAF

--------------------------------------------------------------
>81405_81405_5_SH3BGRL-DIAPH2_SH3BGRL_chrX_80457744_ENST00000373212_DIAPH2_chrX_96354693_ENST00000373061_length(transcript)=2643nt_BP=303nt
CGAGATTCCCTATTAAAAAAAAATAGAATTGATGCAAACAGCCTGTTCCTTCCGGGGTTTTGGGCTGGAACTGCAGCGCTTAGAGAGCTC
GGTGGAAGCTGCTAAAGGCGGAGGCGGGGCTCTGGCGAGTTCTCCTTCCACCTTCCCCCACCCTTCTCTGCCAACCGCTGTTTCAGCCCC
TAGCTGGATTCCAGCCATTGCTGCAGCTGCTCCACAGCCCTTTTCAGGACCCAAACAACCGCAGCCGCTGTTCCCAGGATGGTGATCCGT
GTATATATTGCATCTTCCTCTGGCTCTACAGCGAACCTTGTGAAACATCTTCCTGAGCAGAAGATACTCAACGAATTAGCAGAGCTTAAG
AATGAATATGATGACCTCTGTGAGCCTGAACAATTTGGAGTTGTGATGAGCTCTGTGAAAATGTTACAGCCTCGTCTCAGTAGTATCCTG
TTCAAGCTCACATTTGAAGAACACATAAACAACATCAAACCAAGCATCATAGCAGTAACTCTTGCCTGTGAAGAACTGAAGAAAAGTGAA
AGCTTTAACAGACTTTTAGAGTTAGTTCTTCTTGTTGGAAACTACATGAACTCAGGCTCAAGAAATGCCCAGTCTTTGGGATTTAAGATC
AACTTCCTTTGTAAGATCAGAGATACTAAATCAGCGGATCAAAAAACAACCCTTTTGCATTTTATTGCCGACATTTGTGAGGAAAAATAT
CGAGATATCCTAAAATTTCCTGAAGAACTGGAACACGTAGAAAGTGCAAGCAAAGTTTCAGCTCAAATTCTCAAGAGCAACCTTGCATCA
ATGGAACAACAAATTGTTCATCTGGAACGTGACATCAAGAAATTCCCCCAAGCAGAAAATCAACACGATAAGTTTGTGGAAAAGATGACC
ATCTTTACAAAGACTGCCCGAGAACAGTATGAAAAACTCTCCACCATGCACAACAACATGATGAAGCTCTATGAGAATCTTGGAGAATAC
TTCATTTTTGACTCAAAGACAGTGAGCATAGAAGAGTTCTTTGGTGATCTCAACAACTTCCGAACTTTGTTTTTGGAAGCAGTGAGAGAA
AACAATAAGAGAAGAGAAATGGAAGAGAAGACCAGGAGGGCAAAACTTGCAAAAGAGAAAGCTGAACAAGAAAAGTTAGAACGCCAGAAG
AAAAAGAAACAACTCATTGATATAAACAAAGAGGGTGATGAGACTGGTGTGATGGATAATCTTCTAGAAGCCCTACAATCAGGTGCAGCA
TTCAGAGACCGTCGAAAGCGGATTCCAAGGAATCCAGATAACAGACGAGTACCTTTGGAAAGGTCACGCTCTCGCCACAATGGAGCTATC
TCATCTAAGTGATTCCTGATGCCAAAGAATATGAAAATATTTAAGTAAAAACAAAATGATGCATTTTGAGAAGAACAAAGTGTGCACTCA
GCGGCTGGAAAGGAAATAAGTGCATTTCTGCAAAGATCAAGATAAGCTGGATGAAGTAGTGTGCATTTGTAATACTATTGCAAGACTCCT
CCCACAATTATTCTAATCTGAACACAGTTATCAGGATTACAAAATGTGTTCCATTTTAGTGTAAAGATGTGTATCATTTGTAATTGTGTG
TGACCTGACTGTGATGATGGAAGTGTAAGAAATTGAAGAGTTCTAAGGCTTTCAAAAACACTCAGTCAAAAATTTAAAATCTTAAATGTG
TAAGTCACCCCCACCAAAAACAAAAGAGAAGAAAAAGAATAGAAAGAATTATCCAGTGTCAGCTTCCAATCCCTAGTACATATATAATAG
AAAAGGGCCAAGAAAAATATGCATCTTGATTTGGAGAGAGGCTAATATTATGCACACTGTAAGAGAAGCCATTTTGGAAATTCACGAAAG
TACTGCTCCACCCCAGTTGAGTTATTTAGAATTTTATCTCAAGTGAAAGCTGATGGATTCATCTGCTTTGGCTGAAATTAAACTTATCAT
TAGTCTAGCTAGCATTTCAGCATGATATTGCAAGCACTTCTCATTGCTAAAAATAAATAAACCAAAGTTTAACCGAATCAGTTAGGGAAA
GTGATTTAAACTTTATTTAAAGAGGTATTTTCTAATTATGCACAGATATCTACTTTATACAAATACTTTATATGGCTATTTTTGAGAAAA
CCCTCACATTTTAATGTTTATGCTAGGGATGAACCTGAAAATTCTATTACGTTTATTTAGATTTCAAAGGCAAATATTGATTCCTATGCT
CTGTGGTTTATTTCTTTTTTCTATTGCTTCTTTCTCCCTTGAGTCCCTTGAAGGCAGGGAATAGACTTCTAGAAAACCTGAGAGGAAAAA
GAATTCTTTTTACAGGAGGCAGCAGAAAACTGTCTGAAAGGTCAATTGTTTTATCTCCCTTTCCACTCTCTTTCCAATTTCACTTTGGTG
GTCTGAAGAAGAAAAAGAAATTTTATGTATGTATGTGTAAATATGTGTATATATTTCTATCTCTTGCTACAATAATTCCAACTAAGTGAA
CTTCTCAATTATCATCATACTTACTTACCTTATATTAACAAATTAAGATGATGCTGCCAAAACAAGTCTAGCAGGGAAAACAGGTTCTAC

>81405_81405_5_SH3BGRL-DIAPH2_SH3BGRL_chrX_80457744_ENST00000373212_DIAPH2_chrX_96354693_ENST00000373061_length(amino acids)=392AA_BP=40
MDSSHCCSCSTALFRTQTTAAAVPRMVIRVYIASSSGSTANLVKHLPEQKILNELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILF
KLTFEEHINNIKPSIIAVTLACEELKKSESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYR
DILKFPEELEHVESASKVSAQILKSNLASMEQQIVHLERDIKKFPQAENQHDKFVEKMTIFTKTAREQYEKLSTMHNNMMKLYENLGEYF
IFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEKTRRAKLAKEKAEQEKLERQKKKKQLIDINKEGDETGVMDNLLEALQSGAAF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SH3BGRL-DIAPH2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SH3BGRL-DIAPH2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SH3BGRL-DIAPH2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource