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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SH3GLB1-CLCA1 (FusionGDB2 ID:81479)

Fusion Gene Summary for SH3GLB1-CLCA1

check button Fusion gene summary
Fusion gene informationFusion gene name: SH3GLB1-CLCA1
Fusion gene ID: 81479
HgeneTgene
Gene symbol

SH3GLB1

CLCA1

Gene ID

51100

1179

Gene nameSH3 domain containing GRB2 like, endophilin B1chloride channel accessory 1
SynonymsBif-1|CGI-61|PPP1R70|dJ612B15.2CACC|CACC1|CLCRG1|CaCC-1|GOB5|hCLCA1|hCaCC-1
Cytomap

1p22.3

1p22.3

Type of geneprotein-codingprotein-coding
Descriptionendophilin-B1Bax-interacting factor 1SH3 domain-containing GRB2-like protein B1SH3-containing protein SH3GLB1SH3-domain GRB2 like endophilin B1protein phosphatase 1, regulatory subunit 70testicular tissue protein Li 172calcium-activated chloride channel regulator 1CLCA family member 1, chloride channel regulatorcalcium-activated chloride channel family member 1calcium-activated chloride channel protein 1calcium-dependent chloride channel-1chloride channel regulator
Modification date2020031320200313
UniProtAcc.

A8K7I4

Ensembl transtripts involved in fusion geneENST00000535010, ENST00000370558, 
ENST00000482504, 		ENST00000234701, 
ENST00000394711, 
Fusion gene scores* DoF score4 X 5 X 2=403 X 3 X 3=27
# samples 43
** MAII scorelog2(4/40*10)=0log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SH3GLB1 [Title/Abstract] AND CLCA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSH3GLB1(87181548)-CLCA1(86934704), # samples:2
Anticipated loss of major functional domain due to fusion event.SH3GLB1-CLCA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SH3GLB1-CLCA1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSH3GLB1

GO:0031334

positive regulation of protein complex assembly

19074440


check buttonFusion gene breakpoints across SH3GLB1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLCA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-JX-A3PZ-01ASH3GLB1chr1

87170654

+CLCA1chr1

86934704

+
ChimerDB4CESCTCGA-JX-A3PZ-01ASH3GLB1chr1

87181548

+CLCA1chr1

86934704

+


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Fusion Gene ORF analysis for SH3GLB1-CLCA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000535010ENST00000234701SH3GLB1chr1

87170654

+CLCA1chr1

86934704

+
5UTR-3CDSENST00000535010ENST00000394711SH3GLB1chr1

87170654

+CLCA1chr1

86934704

+
Frame-shiftENST00000370558ENST00000234701SH3GLB1chr1

87170654

+CLCA1chr1

86934704

+
Frame-shiftENST00000370558ENST00000394711SH3GLB1chr1

87181548

+CLCA1chr1

86934704

+
Frame-shiftENST00000482504ENST00000234701SH3GLB1chr1

87170654

+CLCA1chr1

86934704

+
Frame-shiftENST00000482504ENST00000394711SH3GLB1chr1

87181548

+CLCA1chr1

86934704

+
In-frameENST00000370558ENST00000234701SH3GLB1chr1

87181548

+CLCA1chr1

86934704

+
In-frameENST00000370558ENST00000394711SH3GLB1chr1

87170654

+CLCA1chr1

86934704

+
In-frameENST00000482504ENST00000234701SH3GLB1chr1

87181548

+CLCA1chr1

86934704

+
In-frameENST00000482504ENST00000394711SH3GLB1chr1

87170654

+CLCA1chr1

86934704

+
intron-3CDSENST00000535010ENST00000234701SH3GLB1chr1

87181548

+CLCA1chr1

86934704

+
intron-3CDSENST00000535010ENST00000394711SH3GLB1chr1

87181548

+CLCA1chr1

86934704

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370558SH3GLB1chr187181548+ENST00000234701CLCA1chr186934704+34475385453232895
ENST00000482504SH3GLB1chr187181548+ENST00000234701CLCA1chr186934704+31282192262913895
ENST00000370558SH3GLB1chr187170654+ENST00000394711CLCA1chr186934704+33353964033090895
ENST00000482504SH3GLB1chr187170654+ENST00000394711CLCA1chr186934704+301677842771895

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370558ENST00000234701SH3GLB1chr187181548+CLCA1chr186934704+0.0015934540.9984066
ENST00000482504ENST00000234701SH3GLB1chr187181548+CLCA1chr186934704+0.0015680780.99843186
ENST00000370558ENST00000394711SH3GLB1chr187170654+CLCA1chr186934704+0.0015229210.99847704
ENST00000482504ENST00000394711SH3GLB1chr187170654+CLCA1chr186934704+0.0015449910.99845505

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Fusion Genomic Features for SH3GLB1-CLCA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SH3GLB1-CLCA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:87181548/chr1:86934704)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CLCA1

A8K7I4

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC. {ECO:0000269|PubMed:11445004, ECO:0000269|PubMed:11842292, ECO:0000269|PubMed:11956057, ECO:0000269|PubMed:23112050, ECO:0000269|PubMed:9828122}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSH3GLB1chr1:87181548chr1:86934704ENST00000370558+291_3071366.0RegionNote=Membrane-binding amphipathic helix
HgeneSH3GLB1chr1:87181548chr1:86934704ENST00000370558+291_3771366.0RegionRequired for membrane binding
HgeneSH3GLB1chr1:87181548chr1:86934704ENST00000482504+2111_3071387.0RegionNote=Membrane-binding amphipathic helix
HgeneSH3GLB1chr1:87181548chr1:86934704ENST00000482504+2111_3771387.0RegionRequired for membrane binding
TgeneCLCA1chr1:87170654chr1:86934704ENST00000234701015306_4750915.0DomainVWFA
TgeneCLCA1chr1:87170654chr1:86934704ENST00000394711014306_4750915.0DomainVWFA
TgeneCLCA1chr1:87181548chr1:86934704ENST00000234701015306_4750915.0DomainVWFA
TgeneCLCA1chr1:87181548chr1:86934704ENST00000394711014306_4750915.0DomainVWFA
TgeneCLCA1chr1:87170654chr1:86934704ENST0000023470101546_1990915.0RegionMetalloprotease domain
TgeneCLCA1chr1:87170654chr1:86934704ENST0000039471101446_1990915.0RegionMetalloprotease domain
TgeneCLCA1chr1:87181548chr1:86934704ENST0000023470101546_1990915.0RegionMetalloprotease domain
TgeneCLCA1chr1:87181548chr1:86934704ENST0000039471101446_1990915.0RegionMetalloprotease domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSH3GLB1chr1:87170654chr1:86934704ENST00000370558+19155_19524366.0Coiled coilOntology_term=ECO:0000255
HgeneSH3GLB1chr1:87170654chr1:86934704ENST00000482504+111155_19524387.0Coiled coilOntology_term=ECO:0000255
HgeneSH3GLB1chr1:87170654chr1:86934704ENST00000535010+18155_1950266.0Coiled coilOntology_term=ECO:0000255
HgeneSH3GLB1chr1:87181548chr1:86934704ENST00000370558+29155_19571366.0Coiled coilOntology_term=ECO:0000255
HgeneSH3GLB1chr1:87181548chr1:86934704ENST00000482504+211155_19571387.0Coiled coilOntology_term=ECO:0000255
HgeneSH3GLB1chr1:87181548chr1:86934704ENST00000535010+18155_1950266.0Coiled coilOntology_term=ECO:0000255
HgeneSH3GLB1chr1:87170654chr1:86934704ENST00000370558+1927_26124366.0DomainBAR
HgeneSH3GLB1chr1:87170654chr1:86934704ENST00000370558+19305_36524366.0DomainSH3
HgeneSH3GLB1chr1:87170654chr1:86934704ENST00000482504+11127_26124387.0DomainBAR
HgeneSH3GLB1chr1:87170654chr1:86934704ENST00000482504+111305_36524387.0DomainSH3
HgeneSH3GLB1chr1:87170654chr1:86934704ENST00000535010+1827_2610266.0DomainBAR
HgeneSH3GLB1chr1:87170654chr1:86934704ENST00000535010+18305_3650266.0DomainSH3
HgeneSH3GLB1chr1:87181548chr1:86934704ENST00000370558+2927_26171366.0DomainBAR
HgeneSH3GLB1chr1:87181548chr1:86934704ENST00000370558+29305_36571366.0DomainSH3
HgeneSH3GLB1chr1:87181548chr1:86934704ENST00000482504+21127_26171387.0DomainBAR
HgeneSH3GLB1chr1:87181548chr1:86934704ENST00000482504+211305_36571387.0DomainSH3
HgeneSH3GLB1chr1:87181548chr1:86934704ENST00000535010+1827_2610266.0DomainBAR
HgeneSH3GLB1chr1:87181548chr1:86934704ENST00000535010+18305_3650266.0DomainSH3
HgeneSH3GLB1chr1:87170654chr1:86934704ENST00000370558+191_3024366.0RegionNote=Membrane-binding amphipathic helix
HgeneSH3GLB1chr1:87170654chr1:86934704ENST00000370558+191_3724366.0RegionRequired for membrane binding
HgeneSH3GLB1chr1:87170654chr1:86934704ENST00000482504+1111_3024387.0RegionNote=Membrane-binding amphipathic helix
HgeneSH3GLB1chr1:87170654chr1:86934704ENST00000482504+1111_3724387.0RegionRequired for membrane binding
HgeneSH3GLB1chr1:87170654chr1:86934704ENST00000535010+181_300266.0RegionNote=Membrane-binding amphipathic helix
HgeneSH3GLB1chr1:87170654chr1:86934704ENST00000535010+181_370266.0RegionRequired for membrane binding
HgeneSH3GLB1chr1:87181548chr1:86934704ENST00000535010+181_300266.0RegionNote=Membrane-binding amphipathic helix
HgeneSH3GLB1chr1:87181548chr1:86934704ENST00000535010+181_370266.0RegionRequired for membrane binding


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Fusion Gene Sequence for SH3GLB1-CLCA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81479_81479_1_SH3GLB1-CLCA1_SH3GLB1_chr1_87170654_ENST00000370558_CLCA1_chr1_86934704_ENST00000394711_length(transcript)=3335nt_BP=396nt
GTTTTTCCCTTGGGACCCGGGTCCACACGGCGGGGTCGCCCGTCCATCTCCGGCTCGCCCGCGGGGCCCATCGTCGACGTTAGCGGCCGT
TCTCCGAGCCGACTGACCCATCCTTGGCGCTGCCGCCGCGCGCTTGTTCTCCTCCCTCGCCCCGCCTTCATCCTCCCCGTTCACGGAAAC
GACAGCTGCGGCTGCGGGGCTGGCGCCGCCTCCCTCCACCTACCACGTCTGCCCTCGCCGCTCTAGCCCTGCGCCCCAGCCCGGCCGCGG
CACCTCCGCCTCGCCGCCGCTAGGTCGGCCGGCTCCGCCCGGCTGCCGCCTAGGATGAATATCATGGACTTCAACGTGAAGAAGCTGGCG
GCCGACGCAGGCACCTTCCTCAGTCGCGCCGTGCAGAGGGGCCCTGAGTAATTCACTCATTCAGCTGAACAACAATGGCTATGAAGGCAT
TGTCGTTGCAATCGACCCCAATGTGCCAGAAGATGAAACACTCATTCAACAAATAAAGGACATGGTGACCCAGGCATCTCTGTATCTGCT
TGAAGCTACAGGAAAGCGATTTTATTTCAAAAATGTTGCCATTTTGATTCCTGAAACATGGAAGACAAAGGCTGACTATGTGAGACCAAA
ACTTGAGACCTACAAAAATGCTGATGTTCTGGTTGCTGAGTCTACTCCTCCAGGTAATGATGAACCCTACACTGAGCAGATGGGCAACTG
TGGAGAGAAGGGTGAAAGGATCCACCTCACTCCTGATTTCATTGCAGGAAAAAAGTTAGCTGAATATGGACCACAAGGTAGGGCATTTGT
CCATGAGTGGGCTCATCTACGATGGGGAGTATTTGACGAGTACAATAATGATGAGAAATTCTACTTATCCAATGGAAGAATACAAGCAGT
AAGATGTTCAGCAGGTATTACTGGTACAAATGTAGTAAAGAAGTGTCAGGGAGGCAGCTGTTACACCAAAAGATGCACATTCAATAAAGT
AACAGGACTCTATGAAAAAGGATGTGAGTTTGTTCTCCAATCCCGCCAGACGGAGAAGGCTTCTATAATGTTTGCACAACATGTTGATTC
TATAGTTGAATTCTGTACAGAACAAAACCACAACAAAGAAGCTCCAAACAAGCAAAATCAAAAATGCAATCTCCGAAGCACATGGGAAGT
GATCCGTGATTCTGAGGACTTTAAGAAAACCACTCCTATGACAACACAGCCACCAAATCCCACCTTCTCATTGCTGCAGATTGGACAAAG
AATTGTGTGTTTAGTCCTTGACAAATCTGGAAGCATGGCGACTGGTAACCGCCTCAATCGACTGAATCAAGCAGGCCAGCTTTTCCTGCT
GCAGACAGTTGAGCTGGGGTCCTGGGTTGGGATGGTGACATTTGACAGTGCTGCCCATGTACAAAATGAACTCATACAGATAAACAGTGG
CAGTGACAGGGACACACTCGCCAAAAGATTACCTGCAGCAGCTTCAGGAGGGACGTCCATCTGCAGCGGGCTTCGATCGGCATTTACTGT
GATTAGGAAGAAATATCCAACTGATGGATCTGAAATTGTGCTGCTGACGGATGGGGAAGACAACACTATAAGTGGGTGCTTTAACGAGGT
CAAACAAAGTGGTGCCATCATCCACACAGTCGCTTTGGGGCCCTCTGCAGCTCAAGAACTAGAGGAGCTGTCCAAAATGACAGGAGGTTT
ACAGACATATGCTTCAGATCAAGTTCAGAACAATGGCCTCATTGATGCTTTTGGGGCCCTTTCATCAGGAAATGGAGCTGTCTCTCAGCG
CTCCATCCAGCTTGAGAGTAAGGGATTAACCCTCCAGAACAGCCAGTGGATGAATGGCACAGTGATCGTGGACAGCACCGTGGGAAAGGA
CACTTTGTTTCTTATCACCTGGACAATGCAGCCTCCCCAAATCCTTCTCTGGGATCCCAGTGGACAGAAGCAAGGTGGCTTTGTAGTGGA
CAAAAACACCAAAATGGCCTACCTCCAAATCCCAGGCATTGCTAAGGTTGGCACTTGGAAATACAGTCTGCAAGCAAGCTCACAAACCTT
GACCCTGACTGTCACGTCCCGTGCGTCCAATGCTACCCTGCCTCCAATTACAGTGACTTCCAAAACGAACAAGGACACCAGCAAATTCCC
CAGCCCTCTGGTAGTTTATGCAAATATTCGCCAAGGAGCCTCCCCAATTCTCAGGGCCAGTGTCACAGCCCTGATTGAATCAGTGAATGG
AAAAACAGTTACCTTGGAACTACTGGATAATGGAGCAGGTGCTGATGCTACTAAGGATGACGGTGTCTACTCAAGGTATTTCACAACTTA
TGACACGAATGGTAGATACAGTGTAAAAGTGCGGGCTCTGGGAGGAGTTAACGCAGCCAGACGGAGAGTGATACCCCAGCAGAGTGGAGC
ACTGTACATACCTGGCTGGATTGAGAATGATGAAATACAATGGAATCCACCAAGACCTGAAATTAATAAGGATGATGTTCAACACAAGCA
AGTGTGTTTCAGCAGAACATCCTCGGGAGGCTCATTTGTGGCTTCTGATGTCCCAAATGCTCCCATACCTGATCTCTTCCCACCTGGCCA
AATCACCGACCTGAAGGCGGAAATTCACGGGGGCAGTCTCATTAATCTGACTTGGACAGCTCCTGGGGATGATTATGACCATGGAACAGC
TCACAAGTATATCATTCGAATAAGTACAAGTATTCTTGATCTCAGAGACAAGTTCAATGAATCTCTTCAAGTGAATACTACTGCTCTCAT
CCCAAAGGAAGCCAACTCTGAGGAAGTCTTTTTGTTTAAACCAGAAAACATTACTTTTGAAAATGGCACAGATCTTTTCATTGCTATTCA
GGCTGTTGATAAGGTCGATCTGAAATCAGAAATATCCAACATTGCACGAGTATCTTTGTTTATTCCTCCACAGACTCCGCCAGAGACACC
TAGTCCTGATGAAACGTCTGCTCCTTGTCCTAATATTCATATCAACAGCACCATTCCTGGCATTCACATTTTAAAAATTATGTGGAAGTG
GATAGGAGAACTGCAGCTGTCAATAGCCTAGGGCTGAATTTTTGTCAGATAAATAAAATAAATCATTCATCCTTTTTTTTGATTATAAAA
TTTTCTAAAATGTATTTTAGACTTCCTGTAGGGGGCGATATACTAAATGTATATAGTACATTTATACTAAATGTATTCCTGTAGGGGGCG
ATATACTAAATGTATTTTAGACTTCCTGTAGGGGGCGATAAAATAAAATGCTAAACAACTGGGTATACATGCATAAAAACTATCCATTCA

>81479_81479_1_SH3GLB1-CLCA1_SH3GLB1_chr1_87170654_ENST00000370558_CLCA1_chr1_86934704_ENST00000394711_length(amino acids)=895AA_BP=
MSNSLIQLNNNGYEGIVVAIDPNVPEDETLIQQIKDMVTQASLYLLEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAES
TPPGNDEPYTEQMGNCGEKGERIHLTPDFIAGKKLAEYGPQGRAFVHEWAHLRWGVFDEYNNDEKFYLSNGRIQAVRCSAGITGTNVVKK
CQGGSCYTKRCTFNKVTGLYEKGCEFVLQSRQTEKASIMFAQHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVIRDSEDFKKTTPMT
TQPPNPTFSLLQIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQTVELGSWVGMVTFDSAAHVQNELIQINSGSDRDTLAKRLPAAA
SGGTSICSGLRSAFTVIRKKYPTDGSEIVLLTDGEDNTISGCFNEVKQSGAIIHTVALGPSAAQELEELSKMTGGLQTYASDQVQNNGLI
DAFGALSSGNGAVSQRSIQLESKGLTLQNSQWMNGTVIVDSTVGKDTLFLITWTMQPPQILLWDPSGQKQGGFVVDKNTKMAYLQIPGIA
KVGTWKYSLQASSQTLTLTVTSRASNATLPPITVTSKTNKDTSKFPSPLVVYANIRQGASPILRASVTALIESVNGKTVTLELLDNGAGA
DATKDDGVYSRYFTTYDTNGRYSVKVRALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQVCFSRTSSGGSFVA
SDVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDYDHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKP

--------------------------------------------------------------
>81479_81479_2_SH3GLB1-CLCA1_SH3GLB1_chr1_87170654_ENST00000482504_CLCA1_chr1_86934704_ENST00000394711_length(transcript)=3016nt_BP=77nt
CTAGGATGAATATCATGGACTTCAACGTGAAGAAGCTGGCGGCCGACGCAGGCACCTTCCTCAGTCGCGCCGTGCAGAGGGGCCCTGAGT
AATTCACTCATTCAGCTGAACAACAATGGCTATGAAGGCATTGTCGTTGCAATCGACCCCAATGTGCCAGAAGATGAAACACTCATTCAA
CAAATAAAGGACATGGTGACCCAGGCATCTCTGTATCTGCTTGAAGCTACAGGAAAGCGATTTTATTTCAAAAATGTTGCCATTTTGATT
CCTGAAACATGGAAGACAAAGGCTGACTATGTGAGACCAAAACTTGAGACCTACAAAAATGCTGATGTTCTGGTTGCTGAGTCTACTCCT
CCAGGTAATGATGAACCCTACACTGAGCAGATGGGCAACTGTGGAGAGAAGGGTGAAAGGATCCACCTCACTCCTGATTTCATTGCAGGA
AAAAAGTTAGCTGAATATGGACCACAAGGTAGGGCATTTGTCCATGAGTGGGCTCATCTACGATGGGGAGTATTTGACGAGTACAATAAT
GATGAGAAATTCTACTTATCCAATGGAAGAATACAAGCAGTAAGATGTTCAGCAGGTATTACTGGTACAAATGTAGTAAAGAAGTGTCAG
GGAGGCAGCTGTTACACCAAAAGATGCACATTCAATAAAGTAACAGGACTCTATGAAAAAGGATGTGAGTTTGTTCTCCAATCCCGCCAG
ACGGAGAAGGCTTCTATAATGTTTGCACAACATGTTGATTCTATAGTTGAATTCTGTACAGAACAAAACCACAACAAAGAAGCTCCAAAC
AAGCAAAATCAAAAATGCAATCTCCGAAGCACATGGGAAGTGATCCGTGATTCTGAGGACTTTAAGAAAACCACTCCTATGACAACACAG
CCACCAAATCCCACCTTCTCATTGCTGCAGATTGGACAAAGAATTGTGTGTTTAGTCCTTGACAAATCTGGAAGCATGGCGACTGGTAAC
CGCCTCAATCGACTGAATCAAGCAGGCCAGCTTTTCCTGCTGCAGACAGTTGAGCTGGGGTCCTGGGTTGGGATGGTGACATTTGACAGT
GCTGCCCATGTACAAAATGAACTCATACAGATAAACAGTGGCAGTGACAGGGACACACTCGCCAAAAGATTACCTGCAGCAGCTTCAGGA
GGGACGTCCATCTGCAGCGGGCTTCGATCGGCATTTACTGTGATTAGGAAGAAATATCCAACTGATGGATCTGAAATTGTGCTGCTGACG
GATGGGGAAGACAACACTATAAGTGGGTGCTTTAACGAGGTCAAACAAAGTGGTGCCATCATCCACACAGTCGCTTTGGGGCCCTCTGCA
GCTCAAGAACTAGAGGAGCTGTCCAAAATGACAGGAGGTTTACAGACATATGCTTCAGATCAAGTTCAGAACAATGGCCTCATTGATGCT
TTTGGGGCCCTTTCATCAGGAAATGGAGCTGTCTCTCAGCGCTCCATCCAGCTTGAGAGTAAGGGATTAACCCTCCAGAACAGCCAGTGG
ATGAATGGCACAGTGATCGTGGACAGCACCGTGGGAAAGGACACTTTGTTTCTTATCACCTGGACAATGCAGCCTCCCCAAATCCTTCTC
TGGGATCCCAGTGGACAGAAGCAAGGTGGCTTTGTAGTGGACAAAAACACCAAAATGGCCTACCTCCAAATCCCAGGCATTGCTAAGGTT
GGCACTTGGAAATACAGTCTGCAAGCAAGCTCACAAACCTTGACCCTGACTGTCACGTCCCGTGCGTCCAATGCTACCCTGCCTCCAATT
ACAGTGACTTCCAAAACGAACAAGGACACCAGCAAATTCCCCAGCCCTCTGGTAGTTTATGCAAATATTCGCCAAGGAGCCTCCCCAATT
CTCAGGGCCAGTGTCACAGCCCTGATTGAATCAGTGAATGGAAAAACAGTTACCTTGGAACTACTGGATAATGGAGCAGGTGCTGATGCT
ACTAAGGATGACGGTGTCTACTCAAGGTATTTCACAACTTATGACACGAATGGTAGATACAGTGTAAAAGTGCGGGCTCTGGGAGGAGTT
AACGCAGCCAGACGGAGAGTGATACCCCAGCAGAGTGGAGCACTGTACATACCTGGCTGGATTGAGAATGATGAAATACAATGGAATCCA
CCAAGACCTGAAATTAATAAGGATGATGTTCAACACAAGCAAGTGTGTTTCAGCAGAACATCCTCGGGAGGCTCATTTGTGGCTTCTGAT
GTCCCAAATGCTCCCATACCTGATCTCTTCCCACCTGGCCAAATCACCGACCTGAAGGCGGAAATTCACGGGGGCAGTCTCATTAATCTG
ACTTGGACAGCTCCTGGGGATGATTATGACCATGGAACAGCTCACAAGTATATCATTCGAATAAGTACAAGTATTCTTGATCTCAGAGAC
AAGTTCAATGAATCTCTTCAAGTGAATACTACTGCTCTCATCCCAAAGGAAGCCAACTCTGAGGAAGTCTTTTTGTTTAAACCAGAAAAC
ATTACTTTTGAAAATGGCACAGATCTTTTCATTGCTATTCAGGCTGTTGATAAGGTCGATCTGAAATCAGAAATATCCAACATTGCACGA
GTATCTTTGTTTATTCCTCCACAGACTCCGCCAGAGACACCTAGTCCTGATGAAACGTCTGCTCCTTGTCCTAATATTCATATCAACAGC
ACCATTCCTGGCATTCACATTTTAAAAATTATGTGGAAGTGGATAGGAGAACTGCAGCTGTCAATAGCCTAGGGCTGAATTTTTGTCAGA
TAAATAAAATAAATCATTCATCCTTTTTTTTGATTATAAAATTTTCTAAAATGTATTTTAGACTTCCTGTAGGGGGCGATATACTAAATG
TATATAGTACATTTATACTAAATGTATTCCTGTAGGGGGCGATATACTAAATGTATTTTAGACTTCCTGTAGGGGGCGATAAAATAAAAT

>81479_81479_2_SH3GLB1-CLCA1_SH3GLB1_chr1_87170654_ENST00000482504_CLCA1_chr1_86934704_ENST00000394711_length(amino acids)=895AA_BP=
MSNSLIQLNNNGYEGIVVAIDPNVPEDETLIQQIKDMVTQASLYLLEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAES
TPPGNDEPYTEQMGNCGEKGERIHLTPDFIAGKKLAEYGPQGRAFVHEWAHLRWGVFDEYNNDEKFYLSNGRIQAVRCSAGITGTNVVKK
CQGGSCYTKRCTFNKVTGLYEKGCEFVLQSRQTEKASIMFAQHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVIRDSEDFKKTTPMT
TQPPNPTFSLLQIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQTVELGSWVGMVTFDSAAHVQNELIQINSGSDRDTLAKRLPAAA
SGGTSICSGLRSAFTVIRKKYPTDGSEIVLLTDGEDNTISGCFNEVKQSGAIIHTVALGPSAAQELEELSKMTGGLQTYASDQVQNNGLI
DAFGALSSGNGAVSQRSIQLESKGLTLQNSQWMNGTVIVDSTVGKDTLFLITWTMQPPQILLWDPSGQKQGGFVVDKNTKMAYLQIPGIA
KVGTWKYSLQASSQTLTLTVTSRASNATLPPITVTSKTNKDTSKFPSPLVVYANIRQGASPILRASVTALIESVNGKTVTLELLDNGAGA
DATKDDGVYSRYFTTYDTNGRYSVKVRALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQVCFSRTSSGGSFVA
SDVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDYDHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKP

--------------------------------------------------------------
>81479_81479_3_SH3GLB1-CLCA1_SH3GLB1_chr1_87181548_ENST00000370558_CLCA1_chr1_86934704_ENST00000234701_length(transcript)=3447nt_BP=538nt
GTTTTTCCCTTGGGACCCGGGTCCACACGGCGGGGTCGCCCGTCCATCTCCGGCTCGCCCGCGGGGCCCATCGTCGACGTTAGCGGCCGT
TCTCCGAGCCGACTGACCCATCCTTGGCGCTGCCGCCGCGCGCTTGTTCTCCTCCCTCGCCCCGCCTTCATCCTCCCCGTTCACGGAAAC
GACAGCTGCGGCTGCGGGGCTGGCGCCGCCTCCCTCCACCTACCACGTCTGCCCTCGCCGCTCTAGCCCTGCGCCCCAGCCCGGCCGCGG
CACCTCCGCCTCGCCGCCGCTAGGTCGGCCGGCTCCGCCCGGCTGCCGCCTAGGATGAATATCATGGACTTCAACGTGAAGAAGCTGGCG
GCCGACGCAGGCACCTTCCTCAGTCGCGCCGTGCAGTTCACAGAAGAAAAGCTTGGCCAGGCTGAGAAGACAGAATTGGATGCTCACTTA
GAGAACCTCCTTAGCAAAGCTGAATGTACCAAAATATGGACAGAAAAAATAATGAAACAAACTGAAGTGTTATTGCAGCCAAATCCAAAG
GGGCCCTGAGTAATTCACTCATTCAGCTGAACAACAATGGCTATGAAGGCATTGTCGTTGCAATCGACCCCAATGTGCCAGAAGATGAAA
CACTCATTCAACAAATAAAGGACATGGTGACCCAGGCATCTCTGTATCTGCTTGAAGCTACAGGAAAGCGATTTTATTTCAAAAATGTTG
CCATTTTGATTCCTGAAACATGGAAGACAAAGGCTGACTATGTGAGACCAAAACTTGAGACCTACAAAAATGCTGATGTTCTGGTTGCTG
AGTCTACTCCTCCAGGTAATGATGAACCCTACACTGAGCAGATGGGCAACTGTGGAGAGAAGGGTGAAAGGATCCACCTCACTCCTGATT
TCATTGCAGGAAAAAAGTTAGCTGAATATGGACCACAAGGTAGGGCATTTGTCCATGAGTGGGCTCATCTACGATGGGGAGTATTTGACG
AGTACAATAATGATGAGAAATTCTACTTATCCAATGGAAGAATACAAGCAGTAAGATGTTCAGCAGGTATTACTGGTACAAATGTAGTAA
AGAAGTGTCAGGGAGGCAGCTGTTACACCAAAAGATGCACATTCAATAAAGTAACAGGACTCTATGAAAAAGGATGTGAGTTTGTTCTCC
AATCCCGCCAGACGGAGAAGGCTTCTATAATGTTTGCACAACATGTTGATTCTATAGTTGAATTCTGTACAGAACAAAACCACAACAAAG
AAGCTCCAAACAAGCAAAATCAAAAATGCAATCTCCGAAGCACATGGGAAGTGATCCGTGATTCTGAGGACTTTAAGAAAACCACTCCTA
TGACAACACAGCCACCAAATCCCACCTTCTCATTGCTGCAGATTGGACAAAGAATTGTGTGTTTAGTCCTTGACAAATCTGGAAGCATGG
CGACTGGTAACCGCCTCAATCGACTGAATCAAGCAGGCCAGCTTTTCCTGCTGCAGACAGTTGAGCTGGGGTCCTGGGTTGGGATGGTGA
CATTTGACAGTGCTGCCCATGTACAAAATGAACTCATACAGATAAACAGTGGCAGTGACAGGGACACACTCGCCAAAAGATTACCTGCAG
CAGCTTCAGGAGGGACGTCCATCTGCAGCGGGCTTCGATCGGCATTTACTGTGATTAGGAAGAAATATCCAACTGATGGATCTGAAATTG
TGCTGCTGACGGATGGGGAAGACAACACTATAAGTGGGTGCTTTAACGAGGTCAAACAAAGTGGTGCCATCATCCACACAGTCGCTTTGG
GGCCCTCTGCAGCTCAAGAACTAGAGGAGCTGTCCAAAATGACAGGAGGTTTACAGACATATGCTTCAGATCAAGTTCAGAACAATGGCC
TCATTGATGCTTTTGGGGCCCTTTCATCAGGAAATGGAGCTGTCTCTCAGCGCTCCATCCAGCTTGAGAGTAAGGGATTAACCCTCCAGA
ACAGCCAGTGGATGAATGGCACAGTGATCGTGGACAGCACCGTGGGAAAGGACACTTTGTTTCTTATCACCTGGACAATGCAGCCTCCCC
AAATCCTTCTCTGGGATCCCAGTGGACAGAAGCAAGGTGGCTTTGTAGTGGACAAAAACACCAAAATGGCCTACCTCCAAATCCCAGGCA
TTGCTAAGGTTGGCACTTGGAAATACAGTCTGCAAGCAAGCTCACAAACCTTGACCCTGACTGTCACGTCCCGTGCGTCCAATGCTACCC
TGCCTCCAATTACAGTGACTTCCAAAACGAACAAGGACACCAGCAAATTCCCCAGCCCTCTGGTAGTTTATGCAAATATTCGCCAAGGAG
CCTCCCCAATTCTCAGGGCCAGTGTCACAGCCCTGATTGAATCAGTGAATGGAAAAACAGTTACCTTGGAACTACTGGATAATGGAGCAG
GTGCTGATGCTACTAAGGATGACGGTGTCTACTCAAGGTATTTCACAACTTATGACACGAATGGTAGATACAGTGTAAAAGTGCGGGCTC
TGGGAGGAGTTAACGCAGCCAGACGGAGAGTGATACCCCAGCAGAGTGGAGCACTGTACATACCTGGCTGGATTGAGAATGATGAAATAC
AATGGAATCCACCAAGACCTGAAATTAATAAGGATGATGTTCAACACAAGCAAGTGTGTTTCAGCAGAACATCCTCGGGAGGCTCATTTG
TGGCTTCTGATGTCCCAAATGCTCCCATACCTGATCTCTTCCCACCTGGCCAAATCACCGACCTGAAGGCGGAAATTCACGGGGGCAGTC
TCATTAATCTGACTTGGACAGCTCCTGGGGATGATTATGACCATGGAACAGCTCACAAGTATATCATTCGAATAAGTACAAGTATTCTTG
ATCTCAGAGACAAGTTCAATGAATCTCTTCAAGTGAATACTACTGCTCTCATCCCAAAGGAAGCCAACTCTGAGGAAGTCTTTTTGTTTA
AACCAGAAAACATTACTTTTGAAAATGGCACAGATCTTTTCATTGCTATTCAGGCTGTTGATAAGGTCGATCTGAAATCAGAAATATCCA
ACATTGCACGAGTATCTTTGTTTATTCCTCCACAGACTCCGCCAGAGACACCTAGTCCTGATGAAACGTCTGCTCCTTGTCCTAATATTC
ATATCAACAGCACCATTCCTGGCATTCACATTTTAAAAATTATGTGGAAGTGGATAGGAGAACTGCAGCTGTCAATAGCCTAGGGCTGAA
TTTTTGTCAGATAAATAAAATAAATCATTCATCCTTTTTTTTGATTATAAAATTTTCTAAAATGTATTTTAGACTTCCTGTAGGGGGCGA
TATACTAAATGTATATAGTACATTTATACTAAATGTATTCCTGTAGGGGGCGATATACTAAATGTATTTTAGACTTCCTGTAGGGGGCGA

>81479_81479_3_SH3GLB1-CLCA1_SH3GLB1_chr1_87181548_ENST00000370558_CLCA1_chr1_86934704_ENST00000234701_length(amino acids)=895AA_BP=
MSNSLIQLNNNGYEGIVVAIDPNVPEDETLIQQIKDMVTQASLYLLEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAES
TPPGNDEPYTEQMGNCGEKGERIHLTPDFIAGKKLAEYGPQGRAFVHEWAHLRWGVFDEYNNDEKFYLSNGRIQAVRCSAGITGTNVVKK
CQGGSCYTKRCTFNKVTGLYEKGCEFVLQSRQTEKASIMFAQHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVIRDSEDFKKTTPMT
TQPPNPTFSLLQIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQTVELGSWVGMVTFDSAAHVQNELIQINSGSDRDTLAKRLPAAA
SGGTSICSGLRSAFTVIRKKYPTDGSEIVLLTDGEDNTISGCFNEVKQSGAIIHTVALGPSAAQELEELSKMTGGLQTYASDQVQNNGLI
DAFGALSSGNGAVSQRSIQLESKGLTLQNSQWMNGTVIVDSTVGKDTLFLITWTMQPPQILLWDPSGQKQGGFVVDKNTKMAYLQIPGIA
KVGTWKYSLQASSQTLTLTVTSRASNATLPPITVTSKTNKDTSKFPSPLVVYANIRQGASPILRASVTALIESVNGKTVTLELLDNGAGA
DATKDDGVYSRYFTTYDTNGRYSVKVRALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQVCFSRTSSGGSFVA
SDVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDYDHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKP

--------------------------------------------------------------
>81479_81479_4_SH3GLB1-CLCA1_SH3GLB1_chr1_87181548_ENST00000482504_CLCA1_chr1_86934704_ENST00000234701_length(transcript)=3128nt_BP=219nt
CTAGGATGAATATCATGGACTTCAACGTGAAGAAGCTGGCGGCCGACGCAGGCACCTTCCTCAGTCGCGCCGTGCAGTTCACAGAAGAAA
AGCTTGGCCAGGCTGAGAAGACAGAATTGGATGCTCACTTAGAGAACCTCCTTAGCAAAGCTGAATGTACCAAAATATGGACAGAAAAAA
TAATGAAACAAACTGAAGTGTTATTGCAGCCAAATCCAAAGGGGCCCTGAGTAATTCACTCATTCAGCTGAACAACAATGGCTATGAAGG
CATTGTCGTTGCAATCGACCCCAATGTGCCAGAAGATGAAACACTCATTCAACAAATAAAGGACATGGTGACCCAGGCATCTCTGTATCT
GCTTGAAGCTACAGGAAAGCGATTTTATTTCAAAAATGTTGCCATTTTGATTCCTGAAACATGGAAGACAAAGGCTGACTATGTGAGACC
AAAACTTGAGACCTACAAAAATGCTGATGTTCTGGTTGCTGAGTCTACTCCTCCAGGTAATGATGAACCCTACACTGAGCAGATGGGCAA
CTGTGGAGAGAAGGGTGAAAGGATCCACCTCACTCCTGATTTCATTGCAGGAAAAAAGTTAGCTGAATATGGACCACAAGGTAGGGCATT
TGTCCATGAGTGGGCTCATCTACGATGGGGAGTATTTGACGAGTACAATAATGATGAGAAATTCTACTTATCCAATGGAAGAATACAAGC
AGTAAGATGTTCAGCAGGTATTACTGGTACAAATGTAGTAAAGAAGTGTCAGGGAGGCAGCTGTTACACCAAAAGATGCACATTCAATAA
AGTAACAGGACTCTATGAAAAAGGATGTGAGTTTGTTCTCCAATCCCGCCAGACGGAGAAGGCTTCTATAATGTTTGCACAACATGTTGA
TTCTATAGTTGAATTCTGTACAGAACAAAACCACAACAAAGAAGCTCCAAACAAGCAAAATCAAAAATGCAATCTCCGAAGCACATGGGA
AGTGATCCGTGATTCTGAGGACTTTAAGAAAACCACTCCTATGACAACACAGCCACCAAATCCCACCTTCTCATTGCTGCAGATTGGACA
AAGAATTGTGTGTTTAGTCCTTGACAAATCTGGAAGCATGGCGACTGGTAACCGCCTCAATCGACTGAATCAAGCAGGCCAGCTTTTCCT
GCTGCAGACAGTTGAGCTGGGGTCCTGGGTTGGGATGGTGACATTTGACAGTGCTGCCCATGTACAAAATGAACTCATACAGATAAACAG
TGGCAGTGACAGGGACACACTCGCCAAAAGATTACCTGCAGCAGCTTCAGGAGGGACGTCCATCTGCAGCGGGCTTCGATCGGCATTTAC
TGTGATTAGGAAGAAATATCCAACTGATGGATCTGAAATTGTGCTGCTGACGGATGGGGAAGACAACACTATAAGTGGGTGCTTTAACGA
GGTCAAACAAAGTGGTGCCATCATCCACACAGTCGCTTTGGGGCCCTCTGCAGCTCAAGAACTAGAGGAGCTGTCCAAAATGACAGGAGG
TTTACAGACATATGCTTCAGATCAAGTTCAGAACAATGGCCTCATTGATGCTTTTGGGGCCCTTTCATCAGGAAATGGAGCTGTCTCTCA
GCGCTCCATCCAGCTTGAGAGTAAGGGATTAACCCTCCAGAACAGCCAGTGGATGAATGGCACAGTGATCGTGGACAGCACCGTGGGAAA
GGACACTTTGTTTCTTATCACCTGGACAATGCAGCCTCCCCAAATCCTTCTCTGGGATCCCAGTGGACAGAAGCAAGGTGGCTTTGTAGT
GGACAAAAACACCAAAATGGCCTACCTCCAAATCCCAGGCATTGCTAAGGTTGGCACTTGGAAATACAGTCTGCAAGCAAGCTCACAAAC
CTTGACCCTGACTGTCACGTCCCGTGCGTCCAATGCTACCCTGCCTCCAATTACAGTGACTTCCAAAACGAACAAGGACACCAGCAAATT
CCCCAGCCCTCTGGTAGTTTATGCAAATATTCGCCAAGGAGCCTCCCCAATTCTCAGGGCCAGTGTCACAGCCCTGATTGAATCAGTGAA
TGGAAAAACAGTTACCTTGGAACTACTGGATAATGGAGCAGGTGCTGATGCTACTAAGGATGACGGTGTCTACTCAAGGTATTTCACAAC
TTATGACACGAATGGTAGATACAGTGTAAAAGTGCGGGCTCTGGGAGGAGTTAACGCAGCCAGACGGAGAGTGATACCCCAGCAGAGTGG
AGCACTGTACATACCTGGCTGGATTGAGAATGATGAAATACAATGGAATCCACCAAGACCTGAAATTAATAAGGATGATGTTCAACACAA
GCAAGTGTGTTTCAGCAGAACATCCTCGGGAGGCTCATTTGTGGCTTCTGATGTCCCAAATGCTCCCATACCTGATCTCTTCCCACCTGG
CCAAATCACCGACCTGAAGGCGGAAATTCACGGGGGCAGTCTCATTAATCTGACTTGGACAGCTCCTGGGGATGATTATGACCATGGAAC
AGCTCACAAGTATATCATTCGAATAAGTACAAGTATTCTTGATCTCAGAGACAAGTTCAATGAATCTCTTCAAGTGAATACTACTGCTCT
CATCCCAAAGGAAGCCAACTCTGAGGAAGTCTTTTTGTTTAAACCAGAAAACATTACTTTTGAAAATGGCACAGATCTTTTCATTGCTAT
TCAGGCTGTTGATAAGGTCGATCTGAAATCAGAAATATCCAACATTGCACGAGTATCTTTGTTTATTCCTCCACAGACTCCGCCAGAGAC
ACCTAGTCCTGATGAAACGTCTGCTCCTTGTCCTAATATTCATATCAACAGCACCATTCCTGGCATTCACATTTTAAAAATTATGTGGAA
GTGGATAGGAGAACTGCAGCTGTCAATAGCCTAGGGCTGAATTTTTGTCAGATAAATAAAATAAATCATTCATCCTTTTTTTTGATTATA
AAATTTTCTAAAATGTATTTTAGACTTCCTGTAGGGGGCGATATACTAAATGTATATAGTACATTTATACTAAATGTATTCCTGTAGGGG

>81479_81479_4_SH3GLB1-CLCA1_SH3GLB1_chr1_87181548_ENST00000482504_CLCA1_chr1_86934704_ENST00000234701_length(amino acids)=895AA_BP=
MSNSLIQLNNNGYEGIVVAIDPNVPEDETLIQQIKDMVTQASLYLLEATGKRFYFKNVAILIPETWKTKADYVRPKLETYKNADVLVAES
TPPGNDEPYTEQMGNCGEKGERIHLTPDFIAGKKLAEYGPQGRAFVHEWAHLRWGVFDEYNNDEKFYLSNGRIQAVRCSAGITGTNVVKK
CQGGSCYTKRCTFNKVTGLYEKGCEFVLQSRQTEKASIMFAQHVDSIVEFCTEQNHNKEAPNKQNQKCNLRSTWEVIRDSEDFKKTTPMT
TQPPNPTFSLLQIGQRIVCLVLDKSGSMATGNRLNRLNQAGQLFLLQTVELGSWVGMVTFDSAAHVQNELIQINSGSDRDTLAKRLPAAA
SGGTSICSGLRSAFTVIRKKYPTDGSEIVLLTDGEDNTISGCFNEVKQSGAIIHTVALGPSAAQELEELSKMTGGLQTYASDQVQNNGLI
DAFGALSSGNGAVSQRSIQLESKGLTLQNSQWMNGTVIVDSTVGKDTLFLITWTMQPPQILLWDPSGQKQGGFVVDKNTKMAYLQIPGIA
KVGTWKYSLQASSQTLTLTVTSRASNATLPPITVTSKTNKDTSKFPSPLVVYANIRQGASPILRASVTALIESVNGKTVTLELLDNGAGA
DATKDDGVYSRYFTTYDTNGRYSVKVRALGGVNAARRRVIPQQSGALYIPGWIENDEIQWNPPRPEINKDDVQHKQVCFSRTSSGGSFVA
SDVPNAPIPDLFPPGQITDLKAEIHGGSLINLTWTAPGDDYDHGTAHKYIIRISTSILDLRDKFNESLQVNTTALIPKEANSEEVFLFKP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SH3GLB1-CLCA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SH3GLB1-CLCA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SH3GLB1-CLCA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource