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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SH3KBP1-RPS6KA3 (FusionGDB2 ID:81498)

Fusion Gene Summary for SH3KBP1-RPS6KA3

check button Fusion gene summary
Fusion gene informationFusion gene name: SH3KBP1-RPS6KA3
Fusion gene ID: 81498
HgeneTgene
Gene symbol

SH3KBP1

RPS6KA3

Gene ID

30011

6197

Gene nameSH3 domain containing kinase binding protein 1ribosomal protein S6 kinase A3
SynonymsAGMX2|CD2BP3|CIN85|GIG10|HSB-1|HSB1|IMD61|MIG18CLS|HU-3|ISPK-1|MAPKAPK1B|MRX19|RSK|RSK2|S6K-alpha3|p90-RSK2|pp90RSK2
Cytomap

Xp22.12

Xp22.12

Type of geneprotein-codingprotein-coding
DescriptionSH3 domain-containing kinase-binding protein 1CD2-binding protein 3SH3-domain kinase binding protein 1Src family kinase-binding protein 1c-Cbl-interacting proteincbl-interacting protein of 85 kDahuman Src family kinase-binding protein 1migration-inribosomal protein S6 kinase alpha-3MAP kinase-activated protein kinase 1bMAPK-activated protein kinase 1bMAPKAP kinase 1bMAPKAPK-1bRSK-2S6K-alpha-3epididymis secretory sperm binding proteininsulin-stimulated protein kinase 1p90-RSK 3ribosomal S6
Modification date2020032720200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000379697, ENST00000397821, 
ENST00000379698, ENST00000379716, 
ENST00000477102, ENST00000541422, 
ENST00000479809, ENST00000379548, 
ENST00000379565, ENST00000540702, 
ENST00000544447, 
Fusion gene scores* DoF score14 X 14 X 5=98010 X 8 X 5=400
# samples 1510
** MAII scorelog2(15/980*10)=-2.70781924850669
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/400*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SH3KBP1 [Title/Abstract] AND RPS6KA3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointRPS6KA3(20252876)-SH3KBP1(19663593), # samples:1
SH3KBP1(19854243)-RPS6KA3(20227522), # samples:1
Anticipated loss of major functional domain due to fusion event.RPS6KA3-SH3KBP1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
RPS6KA3-SH3KBP1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
RPS6KA3-SH3KBP1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
RPS6KA3-SH3KBP1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRPS6KA3

GO:0043154

negative regulation of cysteine-type endopeptidase activity involved in apoptotic process

18402937


check buttonFusion gene breakpoints across SH3KBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RPS6KA3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-AJ-A3QS-01ASH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-


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Fusion Gene ORF analysis for SH3KBP1-RPS6KA3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000379697ENST00000479809SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
5CDS-intronENST00000397821ENST00000479809SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
In-frameENST00000379697ENST00000379548SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
In-frameENST00000379697ENST00000379565SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
In-frameENST00000379697ENST00000540702SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
In-frameENST00000379697ENST00000544447SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
In-frameENST00000397821ENST00000379548SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
In-frameENST00000397821ENST00000379565SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
In-frameENST00000397821ENST00000540702SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
In-frameENST00000397821ENST00000544447SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-3CDSENST00000379698ENST00000379548SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-3CDSENST00000379698ENST00000379565SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-3CDSENST00000379698ENST00000540702SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-3CDSENST00000379698ENST00000544447SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-3CDSENST00000379716ENST00000379548SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-3CDSENST00000379716ENST00000379565SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-3CDSENST00000379716ENST00000540702SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-3CDSENST00000379716ENST00000544447SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-3CDSENST00000477102ENST00000379548SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-3CDSENST00000477102ENST00000379565SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-3CDSENST00000477102ENST00000540702SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-3CDSENST00000477102ENST00000544447SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-3CDSENST00000541422ENST00000379548SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-3CDSENST00000541422ENST00000379565SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-3CDSENST00000541422ENST00000540702SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-3CDSENST00000541422ENST00000544447SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-intronENST00000379698ENST00000479809SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-intronENST00000379716ENST00000479809SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-intronENST00000477102ENST00000479809SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-
intron-intronENST00000541422ENST00000479809SH3KBP1chrX

19854243

-RPS6KA3chrX

20227522

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000397821SH3KBP1chrX19854243-ENST00000379565RPS6KA3chrX20227522-80374532912549752
ENST00000397821SH3KBP1chrX19854243-ENST00000544447RPS6KA3chrX20227522-29824532912549752
ENST00000397821SH3KBP1chrX19854243-ENST00000379548RPS6KA3chrX20227522-28014532912546751
ENST00000397821SH3KBP1chrX19854243-ENST00000540702RPS6KA3chrX20227522-26884532912546751
ENST00000379697SH3KBP1chrX19854243-ENST00000379565RPS6KA3chrX20227522-78953111492407752
ENST00000379697SH3KBP1chrX19854243-ENST00000544447RPS6KA3chrX20227522-28403111492407752
ENST00000379697SH3KBP1chrX19854243-ENST00000379548RPS6KA3chrX20227522-26593111492404751
ENST00000379697SH3KBP1chrX19854243-ENST00000540702RPS6KA3chrX20227522-25463111492404751

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000397821ENST00000379565SH3KBP1chrX19854243-RPS6KA3chrX20227522-0.0001286520.9998714
ENST00000397821ENST00000544447SH3KBP1chrX19854243-RPS6KA3chrX20227522-0.0007157330.9992843
ENST00000397821ENST00000379548SH3KBP1chrX19854243-RPS6KA3chrX20227522-0.0011056630.9988944
ENST00000397821ENST00000540702SH3KBP1chrX19854243-RPS6KA3chrX20227522-0.0010815120.99891853
ENST00000379697ENST00000379565SH3KBP1chrX19854243-RPS6KA3chrX20227522-0.0001122150.9998878
ENST00000379697ENST00000544447SH3KBP1chrX19854243-RPS6KA3chrX20227522-0.0004189850.99958104
ENST00000379697ENST00000379548SH3KBP1chrX19854243-RPS6KA3chrX20227522-0.0006402580.9993598
ENST00000379697ENST00000540702SH3KBP1chrX19854243-RPS6KA3chrX20227522-0.0006297440.9993703

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Fusion Genomic Features for SH3KBP1-RPS6KA3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SH3KBP1-RPS6KA3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:20252876/chrX:19663593)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRPS6KA3chrX:19854243chrX:20227522ENST00000379565122328_39742741.0DomainAGC-kinase C-terminal
TgeneRPS6KA3chrX:19854243chrX:20227522ENST00000379565122422_67942741.0DomainProtein kinase 2
TgeneRPS6KA3chrX:19854243chrX:20227522ENST0000037956512268_32742741.0DomainProtein kinase 1
TgeneRPS6KA3chrX:19854243chrX:20227522ENST00000379565122428_43642741.0Nucleotide bindingATP
TgeneRPS6KA3chrX:19854243chrX:20227522ENST0000037956512274_8242741.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSH3KBP1chrX:19854243chrX:20227522ENST00000379698-117602_6640629.0Coiled coilOntology_term=ECO:0000255
HgeneSH3KBP1chrX:19854243chrX:20227522ENST00000379716-113602_6640428.0Coiled coilOntology_term=ECO:0000255
HgeneSH3KBP1chrX:19854243chrX:20227522ENST00000397821-218602_66454666.0Coiled coilOntology_term=ECO:0000255
HgeneSH3KBP1chrX:19854243chrX:20227522ENST00000379698-117327_4280629.0Compositional biasNote=Pro-rich
HgeneSH3KBP1chrX:19854243chrX:20227522ENST00000379716-113327_4280428.0Compositional biasNote=Pro-rich
HgeneSH3KBP1chrX:19854243chrX:20227522ENST00000397821-218327_42854666.0Compositional biasNote=Pro-rich
HgeneSH3KBP1chrX:19854243chrX:20227522ENST00000379698-1171_580629.0DomainSH3 1
HgeneSH3KBP1chrX:19854243chrX:20227522ENST00000379698-117267_3280629.0DomainSH3 3
HgeneSH3KBP1chrX:19854243chrX:20227522ENST00000379698-11798_1570629.0DomainSH3 2
HgeneSH3KBP1chrX:19854243chrX:20227522ENST00000379716-1131_580428.0DomainSH3 1
HgeneSH3KBP1chrX:19854243chrX:20227522ENST00000379716-113267_3280428.0DomainSH3 3
HgeneSH3KBP1chrX:19854243chrX:20227522ENST00000379716-11398_1570428.0DomainSH3 2
HgeneSH3KBP1chrX:19854243chrX:20227522ENST00000397821-2181_5854666.0DomainSH3 1
HgeneSH3KBP1chrX:19854243chrX:20227522ENST00000397821-218267_32854666.0DomainSH3 3
HgeneSH3KBP1chrX:19854243chrX:20227522ENST00000397821-21898_15754666.0DomainSH3 2


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Fusion Gene Sequence for SH3KBP1-RPS6KA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81498_81498_1_SH3KBP1-RPS6KA3_SH3KBP1_chrX_19854243_ENST00000379697_RPS6KA3_chrX_20227522_ENST00000379548_length(transcript)=2659nt_BP=311nt
GCCGCCACTGAGGAAGAAGCCGGCCCAGCCGCCGCCGCGTCCGGACCCTCGCGCCTGGATCCCAGCGCCCCGATCCCGGCGCCCCAACCC
CCACGCCCGCCTCCGCCAACTTTCACGCTGCCTCGGCGGCCCGGCCCGGCTCGACGCCAATGGTGGAGGCCATAGTGGAGTTTGACTACC
AGGCCCAGCACGATGATGAGCTGACGATCAGCGTGGGTGAAATCATCACCAACATCAGGAAGGAGGATGGAGGCTGGTGGGAGGGACAGA
TCAACGGCAGGAGAGGTTTGTTCCCTGACAACTTTGTAAGAGAAGAAGTCAGTATCAAAGAAATTGCAATCACACATCATGTAAAGGAAG
GACATGAAAAGGCAGATCCTTCCCAGTTTGAACTTTTAAAAGTATTAGGGCAGGGATCATTTGGAAAGGTTTTCTTAGTTAAAAAAATCT
CAGGCTCTGATGCTAGGCAGCTTTATGCCATGAAGGTATTGAAGAAGGCCACACTGAAAGTTCGAGACCGAGTTCGGACAAAAATGGAAC
GTGATATCTTGGTAGAGGTTAATCATCCTTTTATTGTCAAGTTGCATTATGCTTTTCAAACTGAAGGGAAGTTGTATCTTATTTTGGATT
TTCTCAGGGGAGGAGATTTGTTTACACGCTTATCCAAAGAGGTGATGTTCACAGAAGAAGATGTCAAATTCTACTTGGCTGAACTTGCAC
TTGCTTTAGACCATCTACATAGCCTGGGAATAATTTATAGAGACTTAAAACCAGAAAATATACTTCTTGATGAAGAAGGTCACATCAAGT
TAACAGATTTCGGCCTAAGTAAAGAGTCTATTGACCATGAAAAGAAGGCATATTCTTTTTGTGGAACTGTGGAGTATATGGCTCCAGAAG
TAGTTAATCGTCGAGGTCATACTCAGAGTGCTGACTGGTGGTCTTTTGGTGTGTTAATGTTTGAAATGCTTACTGGTACACTCCCTTTCC
AAGGAAAAGATCGAAAAGAAACAATGACTATGATTCTTAAAGCCAAACTTGGAATGCCACAGTTTTTGAGTCCTGAAGCGCAGAGTCTTT
TACGAATGCTTTTCAAGCGAAATCCTGCAAACAGATTAGGTGCAGGACCAGATGGAGTTGAAGAAATTAAAAGACATTCATTTTTCTCAA
CGATAGACTGGAATAAACTGTATAGAAGAGAAATTCATCCGCCATTTAAACCTGCAACGGGCAGGCCTGAAGATACATTCTATTTTGATC
CTGAGTTTACTGCAAAAACTCCCAAAGATTCACCTGGCATTCCACCTAGTGCTAATGCACATCAGCTTTTTCGGGGGTTTAGTTTTGTTG
CTATTACCTCAGATGATGAAAGCCAAGCTATGCAGACAGTTGGTGTACATTCAATTGTTCAGTTACACAGGAACAGTATTCAGTTTACTG
ATGGATATGAAGTAAAAGAAGATATTGGAGTTGGCTCCTACTCTGTTTGCAAGAGATGTATACATAAAGCTACAAACATGGAGTTTGCAG
TGAAGATTATTGATAAAAGCAAGAGAGACCCAACAGAAGAAATTGAAATTCTTCTTCGTTATGGACAGCATCCAAACATTATCACTCTAA
AGGATGTATATGATGATGGAAAGTATGTGTATGTAGTAACAGAACTTATGAAAGGAGGTGAATTGCTGGATAAAATTCTTAGACAAAAAT
TTTTCTCTGAACGAGAGGCCAGTGCTGTCCTGTTCACTATAACTAAAACCGTTGAATATCTTCACGCACAAGGGGTGGTTCATAGAGACT
TGAAACCTAGCAACATTCTTTATGTGGATGAATCTGGTAATCCGGAATCTATTCGAATTTGTGATTTTGGCTTTGCAAAACAGCTGAGAG
CGGAAAATGGTCTTCTCATGACTCCTTGTTACACTGCAAATTTTGTTGCACCAGAGGTTTTAAAAAGACAAGGCTATGATGCTGCTTGTG
ATATATGGAGTCTTGGTGTCCTACTCTATACAATGCTTACCGGTTACACTCCATTTGCAAATGGTCCTGATGATACACCAGAGGAAATAT
TGGCACGAATAGGTAGCGGAAAATTCTCACTCAGTGGTGGTTACTGGAATTCTGTTTCAGACACAGCAAAGGACCTGGTGTCAAAGATGC
TTCATGTAGACCCTCATCAGAGACTGACTGCTGCTCTTGTGCTCAGACATCCTTGGATCGTCCACTGGGACCAACTGCCACAATACCAAC
TAAACAGACAGGATGCACCACATCTAGTAAAGGGTGCCATGGCAGCTACATATTCTGCTTTGAACCGTAATCAGTCACCAGTTTTGGAAC
CAGTAGGCCGCTCTACTCTTGCTCAGCGGAGAGGTATTAAAAAAATCACCTCAACAGCCCTGTGAAGTGACCTCAGTGAGATATTTGGTA
CCATGGTGTAAGCTGATAGCACAAGTTCTGGCGACAGGTAGCACGTATCTGAGAGACACCTGCAAGCACACACTGTCCCAGCTGGTACCC
ATAATGCTGCTGTTCCTGCTGCTGCTCCTGCTTTCCTCTCTTCTCGCTTTAAATGATTGTTAGCAAGTTAGATTTTCCTGGAGCTTCGGA

>81498_81498_1_SH3KBP1-RPS6KA3_SH3KBP1_chrX_19854243_ENST00000379697_RPS6KA3_chrX_20227522_ENST00000379548_length(amino acids)=751AA_BP=54
MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGS
FGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEE
DVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLM
FEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPAT
GRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQLHRNSIQFTDGYEVKEDIGVGSYSVCKRC
IHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEY
LHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFA
NGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSA

--------------------------------------------------------------
>81498_81498_2_SH3KBP1-RPS6KA3_SH3KBP1_chrX_19854243_ENST00000379697_RPS6KA3_chrX_20227522_ENST00000379565_length(transcript)=7895nt_BP=311nt
GCCGCCACTGAGGAAGAAGCCGGCCCAGCCGCCGCCGCGTCCGGACCCTCGCGCCTGGATCCCAGCGCCCCGATCCCGGCGCCCCAACCC
CCACGCCCGCCTCCGCCAACTTTCACGCTGCCTCGGCGGCCCGGCCCGGCTCGACGCCAATGGTGGAGGCCATAGTGGAGTTTGACTACC
AGGCCCAGCACGATGATGAGCTGACGATCAGCGTGGGTGAAATCATCACCAACATCAGGAAGGAGGATGGAGGCTGGTGGGAGGGACAGA
TCAACGGCAGGAGAGGTTTGTTCCCTGACAACTTTGTAAGAGAAGAAGTCAGTATCAAAGAAATTGCAATCACACATCATGTAAAGGAAG
GACATGAAAAGGCAGATCCTTCCCAGTTTGAACTTTTAAAAGTATTAGGGCAGGGATCATTTGGAAAGGTTTTCTTAGTTAAAAAAATCT
CAGGCTCTGATGCTAGGCAGCTTTATGCCATGAAGGTATTGAAGAAGGCCACACTGAAAGTTCGAGACCGAGTTCGGACAAAAATGGAAC
GTGATATCTTGGTAGAGGTTAATCATCCTTTTATTGTCAAGTTGCATTATGCTTTTCAAACTGAAGGGAAGTTGTATCTTATTTTGGATT
TTCTCAGGGGAGGAGATTTGTTTACACGCTTATCCAAAGAGGTGATGTTCACAGAAGAAGATGTCAAATTCTACTTGGCTGAACTTGCAC
TTGCTTTAGACCATCTACATAGCCTGGGAATAATTTATAGAGACTTAAAACCAGAAAATATACTTCTTGATGAAGAAGGTCACATCAAGT
TAACAGATTTCGGCCTAAGTAAAGAGTCTATTGACCATGAAAAGAAGGCATATTCTTTTTGTGGAACTGTGGAGTATATGGCTCCAGAAG
TAGTTAATCGTCGAGGTCATACTCAGAGTGCTGACTGGTGGTCTTTTGGTGTGTTAATGTTTGAAATGCTTACTGGTACACTCCCTTTCC
AAGGAAAAGATCGAAAAGAAACAATGACTATGATTCTTAAAGCCAAACTTGGAATGCCACAGTTTTTGAGTCCTGAAGCGCAGAGTCTTT
TACGAATGCTTTTCAAGCGAAATCCTGCAAACAGATTAGGTGCAGGACCAGATGGAGTTGAAGAAATTAAAAGACATTCATTTTTCTCAA
CGATAGACTGGAATAAACTGTATAGAAGAGAAATTCATCCGCCATTTAAACCTGCAACGGGCAGGCCTGAAGATACATTCTATTTTGATC
CTGAGTTTACTGCAAAAACTCCCAAAGATTCACCTGGCATTCCACCTAGTGCTAATGCACATCAGCTTTTTCGGGGGTTTAGTTTTGTTG
CTATTACCTCAGATGATGAAAGCCAAGCTATGCAGACAGTTGGTGTACATTCAATTGTTCAGCAGTTACACAGGAACAGTATTCAGTTTA
CTGATGGATATGAAGTAAAAGAAGATATTGGAGTTGGCTCCTACTCTGTTTGCAAGAGATGTATACATAAAGCTACAAACATGGAGTTTG
CAGTGAAGATTATTGATAAAAGCAAGAGAGACCCAACAGAAGAAATTGAAATTCTTCTTCGTTATGGACAGCATCCAAACATTATCACTC
TAAAGGATGTATATGATGATGGAAAGTATGTGTATGTAGTAACAGAACTTATGAAAGGAGGTGAATTGCTGGATAAAATTCTTAGACAAA
AATTTTTCTCTGAACGAGAGGCCAGTGCTGTCCTGTTCACTATAACTAAAACCGTTGAATATCTTCACGCACAAGGGGTGGTTCATAGAG
ACTTGAAACCTAGCAACATTCTTTATGTGGATGAATCTGGTAATCCGGAATCTATTCGAATTTGTGATTTTGGCTTTGCAAAACAGCTGA
GAGCGGAAAATGGTCTTCTCATGACTCCTTGTTACACTGCAAATTTTGTTGCACCAGAGGTTTTAAAAAGACAAGGCTATGATGCTGCTT
GTGATATATGGAGTCTTGGTGTCCTACTCTATACAATGCTTACCGGTTACACTCCATTTGCAAATGGTCCTGATGATACACCAGAGGAAA
TATTGGCACGAATAGGTAGCGGAAAATTCTCACTCAGTGGTGGTTACTGGAATTCTGTTTCAGACACAGCAAAGGACCTGGTGTCAAAGA
TGCTTCATGTAGACCCTCATCAGAGACTGACTGCTGCTCTTGTGCTCAGACATCCTTGGATCGTCCACTGGGACCAACTGCCACAATACC
AACTAAACAGACAGGATGCACCACATCTAGTAAAGGGTGCCATGGCAGCTACATATTCTGCTTTGAACCGTAATCAGTCACCAGTTTTGG
AACCAGTAGGCCGCTCTACTCTTGCTCAGCGGAGAGGTATTAAAAAAATCACCTCAACAGCCCTGTGAAGTGACCTCAGTGAGATATTTG
GTACCATGGTGTAAGCTGATAGCACAAGTTCTGGCGACAGGTAGCACGTATCTGAGAGACACCTGCAAGCACACACTGTCCCAGCTGGTA
CCCATAATGCTGCTGTTCCTGCTGCTGCTCCTGCTTTCCTCTCTTCTCGCTTTAAATGATTGTTAGCAAGTTAGATTTTCCTGGAGCTTC
GGAAGAAATGAAAATGGAAACATGATGAAGATATAGTCACTGAATCAATGAGAAAAATAATGAACATATGAATACCACCTAAAAATACAC
TGAATAAAGTACACCATATAGCATTATTTTTATAGGAAATATTTCATGTCCCTTAAATATTCTTTGTTAGTTATAGGGATGGACAGTTTA
TGTTAAGCACTTAGCTTAAACAATCCGTTTATATTAGCACTGTATCCCTTGTGCCATCCAACATTTTGTATGTTTTTGTAAACAGTTCAT
ATACAGTACATTTCTGTACTGCTTTCTTTAATGTATACATGCCTTGTTTAACTTGGAATCTATTATTATTAATCAATTGACTATTAAATC
TGGTTAAATAGTTCACCTGGATTAACAGTATTGTTGGACAGTCCTAAAAATGGCCAGATTGTGGAACAGCTGTTGAATGTAATACTTCCA
AAATGTACATATCTTTCCCCACGTCTGTTTCACTGGTTCGTTCATTTGTTTGTTTCTTAAAGTCAGGTGCTCTGTCAGACTAACCTAGAG
AGCTGTTATGGTAGAGAAAGTTATCATATGTGTGTGGCATGAAATCAAGAATACACCTATGAAGTTAGTCCATATACTTTGCAACTCCTT
AGAGTACTTTTTTCCTTAATTAAGGAAGTAGTCCTTGCACTTCTAATCTTACATAGCATCCATACTTAGAATTTGGCATATCATCTGGGA
TTTTGCCAATATACGTCAAAGCCCTTTAAGAGTCATGGTAAGGAGATGGGTGAAGGAAAATTTAGCAACAGGTAATTGAAGTCCTATTGG
ATATTTCATGTTTAAATAGATATTCTATATTAAACACTAATTTAAATGTAATAAAGGCCAAAGGCCTCTGTATGAAATTGGATTTAAACT
TTCTTATTTTAGGGAATAAAACATTATTGATCAAACAGTATCTGTTCTAACCTAAAATTATAGGTAGGGCAGGCTAAGTGAACAGCATTG
AGTATTTTCTGAATCCCTCATGATAATTTATAGCCACATACTGCTTCCTTTGACTTCAGGAATGATCAGTTTTCATAATGGCCACTGGGC
CTGCTTAGATTGCAGTATTCATTATCTGCATCTAATTTGGTAGTTTCCACAATCGTATTTGATGAAAGAAACTTCAGTCCCCATTATTAC
CTGTGTCTTTGCCAAGCTGCCTAGCATACATCAGTATGTAATGTAAAAGACATATGAGCAAGAAAAAAGTGATTTAACTTACCTCATCAA
GAATGTGCCCCTACAGGCCGGGCGCAGTGGCTCACGCCTGTAATCCCAGCATTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGG
AGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAAATACAAAAATTAGCTGGGCATGGTGGCGTGCACCTGTAAT
CCTAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCTGGGAGGTGGTGGTTGCAGTGAGCCAAGATCACACCATTGCACTCCAG
CCTGGGTGACAGAGTGAGACTCTGTCTCAAGAAGGAAAAAAAAAAAAAAGAATGTACTCATACAGATTTTTGTTAGTCATCATGTAATAA
GCCATTTATATCAGAAACCTTTTTTCCTGCCACAGAAGCTTTAAATTTTCCCCTAAGAGTACAAAGCCAAGAGAGTGTGGTTTATCTAAA
TGTCCTGAAATCCACTTGTCATTCCTTAATTTCTCCTCTATGCAATTAAAGAGAAAGGGGAAATCTATAACATTTCTTTTGCCCAAGTGA
CACAAAAATGATTACTGCATAGAAATCAAATGTAAGTTTAGCTTCTAAATGAAATAATATATAGGAGGGATATCAGAATGTCTAGATAGA
GAAAGTATTTTCAAATTCTTGAATATATGGATGCTATTAAAAGCTGCTTTCCATTGCCTGGAAAGAGAGCTTTTTTCCCTCCTCTATTCA
GTGTTTCAAACTTTGGTCATCTCAAATTATTGTCACTTTTAAAATGTTAATGTCATTCTGAGCAGAAATAGATATATTTTCAGATTTTTT
TACACTGATGCTACTCCGTAATTGCTTAGGAGTATTGTCCATCATAGTATTTTAGAACTAGAAGTAAACACATAAATCCTTATAAATTAC
CCAATCCAACTTTCTCATATTGCATGTAGAGAACCTGAGACACATATCAAAGTCTAGAATCCTTAACTTCTCCCCATTTTGTTTTTTTCC
GCCTCATCACACCATGCTGCCTTTCCCTCATATGATCACCAACCAGTAGCTGAGTTCAAAAACTACATATTTCTTGGGCAGTCCTCTACT
GGTATGTGATGCCAACTTTTATTTCTTTCGAAGATAATTGCCTTCTTTGCCTAGCCAAGCAGCCAATTTTATTGGAGAAAAGCAAGTTAT
ATGTTCACAAAATGGAAGGCTTTCTACCTAAATTTATTTCATCTGTGGTCCTCTTATTCTCTTCCATTGCTTTTGACATACAGTGGAAAA
ACTTGGCCAACGATGTGCTCTAAATATAGTGCTTGTGTTGGGTTAACTTTTCCATTAATTTCTCAACATCAATTATTCAGGCCCCTACAG
TTGTGGTATTGAGGCCCCTAAAGGCTTCTGCCTTTCACCAATTAGTGCTGCCAGTTACTGAGGCTTCTCCCAAAAGGTATCAGTCCAGTC
TTAAAGATATTTCATTGTGAAAGAAGAAACTAAACTATCAGGCCTCTTTTACAAAATGAGAGATTGAATTTAAGCTTGTCAAGCACGTAC
TGGAAGGTATGAATTACACTACCATGTGTTTTGTATCTTCCCTTTCAAGTGATGATGTTAAATGAAGGTAAGTTTTTCATCCTTTTTTAA
TTTTTGTTTTTTATAAATCATTTCAGCTTTTTCTGGTTTATAGAGGTGTCTTATTTCTAATGCAACAGACCCCCAACTTTAACAGATTTG
ATATGGATGCATTTATTCACAAGCAACCCCAAAAGTCCAAAAATGTAATAATTTTGACAAGGCCCAAAGTTGAGATGCTATGAAGCTTGT
GTGTGTGAAAAGTCAGTTATGATTGTCTGGAGAGAAGCTGTGGTGTGTATGCTGTAGAGTTTCCACATTTCACATGCAGTGTACTCCAAA
AAGCGGGTTTGGGTCAACCATTTCCCATCTCTTTTTAAGAAGTGACTGCTGTTGGGGCCAGGGGACATCATGGGAGGTGGGGCTGTCCAG
TTAGCTGTGCCCTGCACCTTCAGCCCAGGAAAGATTTGAACAGAGCAAAGGCTTCAAGAGAGGGCAGAATGTATTCGGCAGAAAAGGGAC
TCAGGTAAGCCCAGCCTGGGATGAGAGCAGAAAAGCATTCAAGATTTGCAGGCCTTGCTATGGATGCGCTTAATCACCATGGAGGCCAGC
AATACCCATCTCAGCATGGCTTTGATATTCTCTACTTCCTGGCCTTTAAAAATGACCTATAATTTTTCAGTTTGCTTTACTATATTTTAT
AAAGAAAATTCTATCTTATGGTTGATTGAGCATTGAGACTTATGAAGGCATTAGGATAGATAGCTCAGGAATGTAAAGGTTCAGAAAAGG
TCTGTTTTCTCAGATTAACAAATATGATGGATTCCATGGCTGACCTTGGTGCTTAAACCAGGAGGTTTCAATCTAGTCCTAGAGTTGTGT
CCCTCTGAAAGGCCCAATGCCATGTAACTAACTTTAAACTGGATATATACTTTGAGCCTTACTTAATTCACAGATAAGTTGACTTAACTC
AGTATTTTTATTTCAATTAATGAAAACAGTCCTCTTTTCAACCCCAGGTTGCTTACATTTTGCTGGTCTCCCCAAGTGACCATTGGTGGA
GACCAATTAATGAAGGAATGAAATTCACTTTATTGGGACTGTGGTATTCAACAGAGCCACACTTAACCACTTTTTCCAATGAAGAATCTC
CAGAATGATAATGCCCAAATATGGATGGCCAAGAAGAATTTGTATCTACGGTGTGCTTTATGTGTTTTTGACACTGCTGTATTCTGTGTG
ATCAAGTGATTTGCAGCTGGTTCCAATGTGACTGAGTGTTCTCAAAGATTTCTAGTAACTAAGTCAACTTAATTTTCTTAAGCCTGGTAT
TACTATCAGCCTCACATTTACCACTTTGATTCTAGTTTTTTAACTGTTCATAACAGGGCATACCGAGGGTTGGGATGAGAGCCTACTTCC
TACCTCTTAAGGCACTTTCCTCATTATTTTGCCATATAATCTTGAACTGCATGATAAGCTGTTTAAATGTCCATGACTTCTCCCAGAGCA
ACTAGCAAAGTATATGACATTTTGAATAGAGATTAGTGGAAAGGAAAATGTAGAGATTTAAGTTCAGAGGTACAAACCTCAATAAAACCT
CCTTAGAGCACATACCATGAGTAGAGTATATGTAAACGTATATGAGAAGAGAGTCGCTATAATAGTCCTCTCTAAGTAGATTAGTTCATT
GTCTAATGGAAGTGAACATCTTTACTCCTGTTATCACCATAGTACTGAATGAACTGTATAATGAGTTTTTCAAACAAGTATTTAAAATAG
AACTTTCACGTACAAAGCAAGGGCATAAAGATTTTGGTTTGTGTTTCTGTAAGTGTAGTTTACCATCTAAAGCTTTGGTTTTTAATTTTA
AAAAAAGCTTCAAGGTATTGCCATTCCTTAGCATCCTTATTGATTATGGGTGATGAGTTTTTAACTCTTAAAATCATATACGTGTATTAG
TTTATCTTAACTGTTGCCCTAAGCAAAAGGGAAGGTATACACCTAAGGGATGTACTTATTTTGCATTTTTGGTCATGGGTGGGAATGGGG
TGGGTGCCTACTTAAATAGTTTTTAAAAAAGAAAAAAATCACAAATATTTTTCTACTGTTATATATGATCTTCCTTTATACTAGTTTCTC
TCTAGTAAGGCATGCCAGAAGCCCAAGATACCATATCATGAATTCTTACATATTGTACCTTTTGTTGGTGGTTAAATCGCATCAGATGCT
TGGCATTGCTGCCATAATTATAAAATGCTTGTAAAGGATCAAATATCACTAAATACTTTAAATTGTTTTACTTAAGAGTCTAATCTGGGA
AGTTTTCAAATCATACTATTAATGTGTAATCTAAGCTCTTCAGATGTATCCATGAATAATCCTGGAACAATATTGCTTGTATTCCTGTCA

>81498_81498_2_SH3KBP1-RPS6KA3_SH3KBP1_chrX_19854243_ENST00000379697_RPS6KA3_chrX_20227522_ENST00000379565_length(amino acids)=752AA_BP=54
MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGS
FGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEE
DVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLM
FEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPAT
GRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKR
CIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVE
YLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPF
ANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYS

--------------------------------------------------------------
>81498_81498_3_SH3KBP1-RPS6KA3_SH3KBP1_chrX_19854243_ENST00000379697_RPS6KA3_chrX_20227522_ENST00000540702_length(transcript)=2546nt_BP=311nt
GCCGCCACTGAGGAAGAAGCCGGCCCAGCCGCCGCCGCGTCCGGACCCTCGCGCCTGGATCCCAGCGCCCCGATCCCGGCGCCCCAACCC
CCACGCCCGCCTCCGCCAACTTTCACGCTGCCTCGGCGGCCCGGCCCGGCTCGACGCCAATGGTGGAGGCCATAGTGGAGTTTGACTACC
AGGCCCAGCACGATGATGAGCTGACGATCAGCGTGGGTGAAATCATCACCAACATCAGGAAGGAGGATGGAGGCTGGTGGGAGGGACAGA
TCAACGGCAGGAGAGGTTTGTTCCCTGACAACTTTGTAAGAGAAGAAGTCAGTATCAAAGAAATTGCAATCACACATCATGTAAAGGAAG
GACATGAAAAGGCAGATCCTTCCCAGTTTGAACTTTTAAAAGTATTAGGGCAGGGATCATTTGGAAAGGTTTTCTTAGTTAAAAAAATCT
CAGGCTCTGATGCTAGGCAGCTTTATGCCATGAAGGTATTGAAGAAGGCCACACTGAAAGTTCGAGACCGAGTTCGGACAAAAATGGAAC
GTGATATCTTGGTAGAGGTTAATCATCCTTTTATTGTCAAGTTGCATTATGCTTTTCAAACTGAAGGGAAGTTGTATCTTATTTTGGATT
TTCTCAGGGGAGGAGATTTGTTTACACGCTTATCCAAAGAGGTGATGTTCACAGAAGAAGATGTCAAATTCTACTTGGCTGAACTTGCAC
TTGCTTTAGACCATCTACATAGCCTGGGAATAATTTATAGAGACTTAAAACCAGAAAATATACTTCTTGATGAAGAAGGTCACATCAAGT
TAACAGATTTCGGCCTAAGTAAAGAGTCTATTGACCATGAAAAGAAGGCATATTCTTTTTGTGGAACTGTGGAGTATATGGCTCCAGAAG
TAGTTAATCGTCGAGGTCATACTCAGAGTGCTGACTGGTGGTCTTTTGGTGTGTTAATGTTTGAAATGCTTACTGGTACACTCCCTTTCC
AAGGAAAAGATCGAAAAGAAACAATGACTATGATTCTTAAAGCCAAACTTGGAATGCCACAGTTTTTGAGTCCTGAAGCGCAGAGTCTTT
TACGAATGCTTTTCAAGCGAAATCCTGCAAACAGATTAGGTGCAGGACCAGATGGAGTTGAAGAAATTAAAAGACATTCATTTTTCTCAA
CGATAGACTGGAATAAACTGTATAGAAGAGAAATTCATCCGCCATTTAAACCTGCAACGGGCAGGCCTGAAGATACATTCTATTTTGATC
CTGAGTTTACTGCAAAAACTCCCAAAGATTCACCTGGCATTCCACCTAGTGCTAATGCACATCAGCTTTTTCGGGGGTTTAGTTTTGTTG
CTATTACCTCAGATGATGAAAGCCAAGCTATGCAGACAGTTGGTGTACATTCAATTGTTCAGTTACACAGGAACAGTATTCAGTTTACTG
ATGGATATGAAGTAAAAGAAGATATTGGAGTTGGCTCCTACTCTGTTTGCAAGAGATGTATACATAAAGCTACAAACATGGAGTTTGCAG
TGAAGATTATTGATAAAAGCAAGAGAGACCCAACAGAAGAAATTGAAATTCTTCTTCGTTATGGACAGCATCCAAACATTATCACTCTAA
AGGATGTATATGATGATGGAAAGTATGTGTATGTAGTAACAGAACTTATGAAAGGAGGTGAATTGCTGGATAAAATTCTTAGACAAAAAT
TTTTCTCTGAACGAGAGGCCAGTGCTGTCCTGTTCACTATAACTAAAACCGTTGAATATCTTCACGCACAAGGGGTGGTTCATAGAGACT
TGAAACCTAGCAACATTCTTTATGTGGATGAATCTGGTAATCCGGAATCTATTCGAATTTGTGATTTTGGCTTTGCAAAACAGCTGAGAG
CGGAAAATGGTCTTCTCATGACTCCTTGTTACACTGCAAATTTTGTTGCACCAGAGGTTTTAAAAAGACAAGGCTATGATGCTGCTTGTG
ATATATGGAGTCTTGGTGTCCTACTCTATACAATGCTTACCGGTTACACTCCATTTGCAAATGGTCCTGATGATACACCAGAGGAAATAT
TGGCACGAATAGGTAGCGGAAAATTCTCACTCAGTGGTGGTTACTGGAATTCTGTTTCAGACACAGCAAAGGACCTGGTGTCAAAGATGC
TTCATGTAGACCCTCATCAGAGACTGACTGCTGCTCTTGTGCTCAGACATCCTTGGATCGTCCACTGGGACCAACTGCCACAATACCAAC
TAAACAGACAGGATGCACCACATCTAGTAAAGGGTGCCATGGCAGCTACATATTCTGCTTTGAACCGTAATCAGTCACCAGTTTTGGAAC
CAGTAGGCCGCTCTACTCTTGCTCAGCGGAGAGGTATTAAAAAAATCACCTCAACAGCCCTGTGAAGTGACCTCAGTGAGATATTTGGTA
CCATGGTGTAAGCTGATAGCACAAGTTCTGGCGACAGGTAGCACGTATCTGAGAGACACCTGCAAGCACACACTGTCCCAGCTGGTACCC

>81498_81498_3_SH3KBP1-RPS6KA3_SH3KBP1_chrX_19854243_ENST00000379697_RPS6KA3_chrX_20227522_ENST00000540702_length(amino acids)=751AA_BP=54
MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGS
FGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEE
DVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLM
FEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPAT
GRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQLHRNSIQFTDGYEVKEDIGVGSYSVCKRC
IHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEY
LHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFA
NGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSA

--------------------------------------------------------------
>81498_81498_4_SH3KBP1-RPS6KA3_SH3KBP1_chrX_19854243_ENST00000379697_RPS6KA3_chrX_20227522_ENST00000544447_length(transcript)=2840nt_BP=311nt
GCCGCCACTGAGGAAGAAGCCGGCCCAGCCGCCGCCGCGTCCGGACCCTCGCGCCTGGATCCCAGCGCCCCGATCCCGGCGCCCCAACCC
CCACGCCCGCCTCCGCCAACTTTCACGCTGCCTCGGCGGCCCGGCCCGGCTCGACGCCAATGGTGGAGGCCATAGTGGAGTTTGACTACC
AGGCCCAGCACGATGATGAGCTGACGATCAGCGTGGGTGAAATCATCACCAACATCAGGAAGGAGGATGGAGGCTGGTGGGAGGGACAGA
TCAACGGCAGGAGAGGTTTGTTCCCTGACAACTTTGTAAGAGAAGAAGTCAGTATCAAAGAAATTGCAATCACACATCATGTAAAGGAAG
GACATGAAAAGGCAGATCCTTCCCAGTTTGAACTTTTAAAAGTATTAGGGCAGGGATCATTTGGAAAGGTTTTCTTAGTTAAAAAAATCT
CAGGCTCTGATGCTAGGCAGCTTTATGCCATGAAGGTATTGAAGAAGGCCACACTGAAAGTTCGAGACCGAGTTCGGACAAAAATGGAAC
GTGATATCTTGGTAGAGGTTAATCATCCTTTTATTGTCAAGTTGCATTATGCTTTTCAAACTGAAGGGAAGTTGTATCTTATTTTGGATT
TTCTCAGGGGAGGAGATTTGTTTACACGCTTATCCAAAGAGGTGATGTTCACAGAAGAAGATGTCAAATTCTACTTGGCTGAACTTGCAC
TTGCTTTAGACCATCTACATAGCCTGGGAATAATTTATAGAGACTTAAAACCAGAAAATATACTTCTTGATGAAGAAGGTCACATCAAGT
TAACAGATTTCGGCCTAAGTAAAGAGTCTATTGACCATGAAAAGAAGGCATATTCTTTTTGTGGAACTGTGGAGTATATGGCTCCAGAAG
TAGTTAATCGTCGAGGTCATACTCAGAGTGCTGACTGGTGGTCTTTTGGTGTGTTAATGTTTGAAATGCTTACTGGTACACTCCCTTTCC
AAGGAAAAGATCGAAAAGAAACAATGACTATGATTCTTAAAGCCAAACTTGGAATGCCACAGTTTTTGAGTCCTGAAGCGCAGAGTCTTT
TACGAATGCTTTTCAAGCGAAATCCTGCAAACAGATTAGGTGCAGGACCAGATGGAGTTGAAGAAATTAAAAGACATTCATTTTTCTCAA
CGATAGACTGGAATAAACTGTATAGAAGAGAAATTCATCCGCCATTTAAACCTGCAACGGGCAGGCCTGAAGATACATTCTATTTTGATC
CTGAGTTTACTGCAAAAACTCCCAAAGATTCACCTGGCATTCCACCTAGTGCTAATGCACATCAGCTTTTTCGGGGGTTTAGTTTTGTTG
CTATTACCTCAGATGATGAAAGCCAAGCTATGCAGACAGTTGGTGTACATTCAATTGTTCAGCAGTTACACAGGAACAGTATTCAGTTTA
CTGATGGATATGAAGTAAAAGAAGATATTGGAGTTGGCTCCTACTCTGTTTGCAAGAGATGTATACATAAAGCTACAAACATGGAGTTTG
CAGTGAAGATTATTGATAAAAGCAAGAGAGACCCAACAGAAGAAATTGAAATTCTTCTTCGTTATGGACAGCATCCAAACATTATCACTC
TAAAGGATGTATATGATGATGGAAAGTATGTGTATGTAGTAACAGAACTTATGAAAGGAGGTGAATTGCTGGATAAAATTCTTAGACAAA
AATTTTTCTCTGAACGAGAGGCCAGTGCTGTCCTGTTCACTATAACTAAAACCGTTGAATATCTTCACGCACAAGGGGTGGTTCATAGAG
ACTTGAAACCTAGCAACATTCTTTATGTGGATGAATCTGGTAATCCGGAATCTATTCGAATTTGTGATTTTGGCTTTGCAAAACAGCTGA
GAGCGGAAAATGGTCTTCTCATGACTCCTTGTTACACTGCAAATTTTGTTGCACCAGAGGTTTTAAAAAGACAAGGCTATGATGCTGCTT
GTGATATATGGAGTCTTGGTGTCCTACTCTATACAATGCTTACCGGTTACACTCCATTTGCAAATGGTCCTGATGATACACCAGAGGAAA
TATTGGCACGAATAGGTAGCGGAAAATTCTCACTCAGTGGTGGTTACTGGAATTCTGTTTCAGACACAGCAAAGGACCTGGTGTCAAAGA
TGCTTCATGTAGACCCTCATCAGAGACTGACTGCTGCTCTTGTGCTCAGACATCCTTGGATCGTCCACTGGGACCAACTGCCACAATACC
AACTAAACAGACAGGATGCACCACATCTAGTAAAGGGTGCCATGGCAGCTACATATTCTGCTTTGAACCGTAATCAGTCACCAGTTTTGG
AACCAGTAGGCCGCTCTACTCTTGCTCAGCGGAGAGGTATTAAAAAAATCACCTCAACAGCCCTGTGAAGTGACCTCAGTGAGATATTTG
GTACCATGGTGTAAGCTGATAGCACAAGTTCTGGCGACAGGTAGCACGTATCTGAGAGACACCTGCAAGCACACACTGTCCCAGCTGGTA
CCCATAATGCTGCTGTTCCTGCTGCTGCTCCTGCTTTCCTCTCTTCTCGCTTTAAATGATTGTTAGCAAGTTAGATTTTCCTGGAGCTTC
GGAAGAAATGAAAATGGAAACATGATGAAGATATAGTCACTGAATCAATGAGAAAAATAATGAACATATGAATACCACCTAAAAATACAC
TGAATAAAGTACACCATATAGCATTATTTTTATAGGAAATATTTCATGTCCCTTAAATATTCTTTGTTAGTTATAGGGATGGACAGTTTA

>81498_81498_4_SH3KBP1-RPS6KA3_SH3KBP1_chrX_19854243_ENST00000379697_RPS6KA3_chrX_20227522_ENST00000544447_length(amino acids)=752AA_BP=54
MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGS
FGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEE
DVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLM
FEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPAT
GRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKR
CIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVE
YLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPF
ANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYS

--------------------------------------------------------------
>81498_81498_5_SH3KBP1-RPS6KA3_SH3KBP1_chrX_19854243_ENST00000397821_RPS6KA3_chrX_20227522_ENST00000379548_length(transcript)=2801nt_BP=453nt
CGCAATTTCCACTCGCGGGGAGCAGGAAACCCGGCGCAGCCGGGCGCATTGGGCCGCGATGCAACAGCAGCAGCAGGAGTCGCCCCGGGG
CAGCAGCGGCAGCAGCAGCAGAGGCAGCAGCGGGCGGCGCTGAGCCGCCGCCGCCGCCACTGAGGAAGAAGCCGGCCCAGCCGCCGCCGC
GTCCGGACCCTCGCGCCTGGATCCCAGCGCCCCGATCCCGGCGCCCCAACCCCCACGCCCGCCTCCGCCAACTTTCACGCTGCCTCGGCG
GCCCGGCCCGGCTCGACGCCAATGGTGGAGGCCATAGTGGAGTTTGACTACCAGGCCCAGCACGATGATGAGCTGACGATCAGCGTGGGT
GAAATCATCACCAACATCAGGAAGGAGGATGGAGGCTGGTGGGAGGGACAGATCAACGGCAGGAGAGGTTTGTTCCCTGACAACTTTGTA
AGAGAAGAAGTCAGTATCAAAGAAATTGCAATCACACATCATGTAAAGGAAGGACATGAAAAGGCAGATCCTTCCCAGTTTGAACTTTTA
AAAGTATTAGGGCAGGGATCATTTGGAAAGGTTTTCTTAGTTAAAAAAATCTCAGGCTCTGATGCTAGGCAGCTTTATGCCATGAAGGTA
TTGAAGAAGGCCACACTGAAAGTTCGAGACCGAGTTCGGACAAAAATGGAACGTGATATCTTGGTAGAGGTTAATCATCCTTTTATTGTC
AAGTTGCATTATGCTTTTCAAACTGAAGGGAAGTTGTATCTTATTTTGGATTTTCTCAGGGGAGGAGATTTGTTTACACGCTTATCCAAA
GAGGTGATGTTCACAGAAGAAGATGTCAAATTCTACTTGGCTGAACTTGCACTTGCTTTAGACCATCTACATAGCCTGGGAATAATTTAT
AGAGACTTAAAACCAGAAAATATACTTCTTGATGAAGAAGGTCACATCAAGTTAACAGATTTCGGCCTAAGTAAAGAGTCTATTGACCAT
GAAAAGAAGGCATATTCTTTTTGTGGAACTGTGGAGTATATGGCTCCAGAAGTAGTTAATCGTCGAGGTCATACTCAGAGTGCTGACTGG
TGGTCTTTTGGTGTGTTAATGTTTGAAATGCTTACTGGTACACTCCCTTTCCAAGGAAAAGATCGAAAAGAAACAATGACTATGATTCTT
AAAGCCAAACTTGGAATGCCACAGTTTTTGAGTCCTGAAGCGCAGAGTCTTTTACGAATGCTTTTCAAGCGAAATCCTGCAAACAGATTA
GGTGCAGGACCAGATGGAGTTGAAGAAATTAAAAGACATTCATTTTTCTCAACGATAGACTGGAATAAACTGTATAGAAGAGAAATTCAT
CCGCCATTTAAACCTGCAACGGGCAGGCCTGAAGATACATTCTATTTTGATCCTGAGTTTACTGCAAAAACTCCCAAAGATTCACCTGGC
ATTCCACCTAGTGCTAATGCACATCAGCTTTTTCGGGGGTTTAGTTTTGTTGCTATTACCTCAGATGATGAAAGCCAAGCTATGCAGACA
GTTGGTGTACATTCAATTGTTCAGTTACACAGGAACAGTATTCAGTTTACTGATGGATATGAAGTAAAAGAAGATATTGGAGTTGGCTCC
TACTCTGTTTGCAAGAGATGTATACATAAAGCTACAAACATGGAGTTTGCAGTGAAGATTATTGATAAAAGCAAGAGAGACCCAACAGAA
GAAATTGAAATTCTTCTTCGTTATGGACAGCATCCAAACATTATCACTCTAAAGGATGTATATGATGATGGAAAGTATGTGTATGTAGTA
ACAGAACTTATGAAAGGAGGTGAATTGCTGGATAAAATTCTTAGACAAAAATTTTTCTCTGAACGAGAGGCCAGTGCTGTCCTGTTCACT
ATAACTAAAACCGTTGAATATCTTCACGCACAAGGGGTGGTTCATAGAGACTTGAAACCTAGCAACATTCTTTATGTGGATGAATCTGGT
AATCCGGAATCTATTCGAATTTGTGATTTTGGCTTTGCAAAACAGCTGAGAGCGGAAAATGGTCTTCTCATGACTCCTTGTTACACTGCA
AATTTTGTTGCACCAGAGGTTTTAAAAAGACAAGGCTATGATGCTGCTTGTGATATATGGAGTCTTGGTGTCCTACTCTATACAATGCTT
ACCGGTTACACTCCATTTGCAAATGGTCCTGATGATACACCAGAGGAAATATTGGCACGAATAGGTAGCGGAAAATTCTCACTCAGTGGT
GGTTACTGGAATTCTGTTTCAGACACAGCAAAGGACCTGGTGTCAAAGATGCTTCATGTAGACCCTCATCAGAGACTGACTGCTGCTCTT
GTGCTCAGACATCCTTGGATCGTCCACTGGGACCAACTGCCACAATACCAACTAAACAGACAGGATGCACCACATCTAGTAAAGGGTGCC
ATGGCAGCTACATATTCTGCTTTGAACCGTAATCAGTCACCAGTTTTGGAACCAGTAGGCCGCTCTACTCTTGCTCAGCGGAGAGGTATT
AAAAAAATCACCTCAACAGCCCTGTGAAGTGACCTCAGTGAGATATTTGGTACCATGGTGTAAGCTGATAGCACAAGTTCTGGCGACAGG
TAGCACGTATCTGAGAGACACCTGCAAGCACACACTGTCCCAGCTGGTACCCATAATGCTGCTGTTCCTGCTGCTGCTCCTGCTTTCCTC
TCTTCTCGCTTTAAATGATTGTTAGCAAGTTAGATTTTCCTGGAGCTTCGGAAGAAATGAAAATGGAAACATGATGAAGATATAGTCACT

>81498_81498_5_SH3KBP1-RPS6KA3_SH3KBP1_chrX_19854243_ENST00000397821_RPS6KA3_chrX_20227522_ENST00000379548_length(amino acids)=751AA_BP=54
MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGS
FGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEE
DVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLM
FEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPAT
GRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQLHRNSIQFTDGYEVKEDIGVGSYSVCKRC
IHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEY
LHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFA
NGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSA

--------------------------------------------------------------
>81498_81498_6_SH3KBP1-RPS6KA3_SH3KBP1_chrX_19854243_ENST00000397821_RPS6KA3_chrX_20227522_ENST00000379565_length(transcript)=8037nt_BP=453nt
CGCAATTTCCACTCGCGGGGAGCAGGAAACCCGGCGCAGCCGGGCGCATTGGGCCGCGATGCAACAGCAGCAGCAGGAGTCGCCCCGGGG
CAGCAGCGGCAGCAGCAGCAGAGGCAGCAGCGGGCGGCGCTGAGCCGCCGCCGCCGCCACTGAGGAAGAAGCCGGCCCAGCCGCCGCCGC
GTCCGGACCCTCGCGCCTGGATCCCAGCGCCCCGATCCCGGCGCCCCAACCCCCACGCCCGCCTCCGCCAACTTTCACGCTGCCTCGGCG
GCCCGGCCCGGCTCGACGCCAATGGTGGAGGCCATAGTGGAGTTTGACTACCAGGCCCAGCACGATGATGAGCTGACGATCAGCGTGGGT
GAAATCATCACCAACATCAGGAAGGAGGATGGAGGCTGGTGGGAGGGACAGATCAACGGCAGGAGAGGTTTGTTCCCTGACAACTTTGTA
AGAGAAGAAGTCAGTATCAAAGAAATTGCAATCACACATCATGTAAAGGAAGGACATGAAAAGGCAGATCCTTCCCAGTTTGAACTTTTA
AAAGTATTAGGGCAGGGATCATTTGGAAAGGTTTTCTTAGTTAAAAAAATCTCAGGCTCTGATGCTAGGCAGCTTTATGCCATGAAGGTA
TTGAAGAAGGCCACACTGAAAGTTCGAGACCGAGTTCGGACAAAAATGGAACGTGATATCTTGGTAGAGGTTAATCATCCTTTTATTGTC
AAGTTGCATTATGCTTTTCAAACTGAAGGGAAGTTGTATCTTATTTTGGATTTTCTCAGGGGAGGAGATTTGTTTACACGCTTATCCAAA
GAGGTGATGTTCACAGAAGAAGATGTCAAATTCTACTTGGCTGAACTTGCACTTGCTTTAGACCATCTACATAGCCTGGGAATAATTTAT
AGAGACTTAAAACCAGAAAATATACTTCTTGATGAAGAAGGTCACATCAAGTTAACAGATTTCGGCCTAAGTAAAGAGTCTATTGACCAT
GAAAAGAAGGCATATTCTTTTTGTGGAACTGTGGAGTATATGGCTCCAGAAGTAGTTAATCGTCGAGGTCATACTCAGAGTGCTGACTGG
TGGTCTTTTGGTGTGTTAATGTTTGAAATGCTTACTGGTACACTCCCTTTCCAAGGAAAAGATCGAAAAGAAACAATGACTATGATTCTT
AAAGCCAAACTTGGAATGCCACAGTTTTTGAGTCCTGAAGCGCAGAGTCTTTTACGAATGCTTTTCAAGCGAAATCCTGCAAACAGATTA
GGTGCAGGACCAGATGGAGTTGAAGAAATTAAAAGACATTCATTTTTCTCAACGATAGACTGGAATAAACTGTATAGAAGAGAAATTCAT
CCGCCATTTAAACCTGCAACGGGCAGGCCTGAAGATACATTCTATTTTGATCCTGAGTTTACTGCAAAAACTCCCAAAGATTCACCTGGC
ATTCCACCTAGTGCTAATGCACATCAGCTTTTTCGGGGGTTTAGTTTTGTTGCTATTACCTCAGATGATGAAAGCCAAGCTATGCAGACA
GTTGGTGTACATTCAATTGTTCAGCAGTTACACAGGAACAGTATTCAGTTTACTGATGGATATGAAGTAAAAGAAGATATTGGAGTTGGC
TCCTACTCTGTTTGCAAGAGATGTATACATAAAGCTACAAACATGGAGTTTGCAGTGAAGATTATTGATAAAAGCAAGAGAGACCCAACA
GAAGAAATTGAAATTCTTCTTCGTTATGGACAGCATCCAAACATTATCACTCTAAAGGATGTATATGATGATGGAAAGTATGTGTATGTA
GTAACAGAACTTATGAAAGGAGGTGAATTGCTGGATAAAATTCTTAGACAAAAATTTTTCTCTGAACGAGAGGCCAGTGCTGTCCTGTTC
ACTATAACTAAAACCGTTGAATATCTTCACGCACAAGGGGTGGTTCATAGAGACTTGAAACCTAGCAACATTCTTTATGTGGATGAATCT
GGTAATCCGGAATCTATTCGAATTTGTGATTTTGGCTTTGCAAAACAGCTGAGAGCGGAAAATGGTCTTCTCATGACTCCTTGTTACACT
GCAAATTTTGTTGCACCAGAGGTTTTAAAAAGACAAGGCTATGATGCTGCTTGTGATATATGGAGTCTTGGTGTCCTACTCTATACAATG
CTTACCGGTTACACTCCATTTGCAAATGGTCCTGATGATACACCAGAGGAAATATTGGCACGAATAGGTAGCGGAAAATTCTCACTCAGT
GGTGGTTACTGGAATTCTGTTTCAGACACAGCAAAGGACCTGGTGTCAAAGATGCTTCATGTAGACCCTCATCAGAGACTGACTGCTGCT
CTTGTGCTCAGACATCCTTGGATCGTCCACTGGGACCAACTGCCACAATACCAACTAAACAGACAGGATGCACCACATCTAGTAAAGGGT
GCCATGGCAGCTACATATTCTGCTTTGAACCGTAATCAGTCACCAGTTTTGGAACCAGTAGGCCGCTCTACTCTTGCTCAGCGGAGAGGT
ATTAAAAAAATCACCTCAACAGCCCTGTGAAGTGACCTCAGTGAGATATTTGGTACCATGGTGTAAGCTGATAGCACAAGTTCTGGCGAC
AGGTAGCACGTATCTGAGAGACACCTGCAAGCACACACTGTCCCAGCTGGTACCCATAATGCTGCTGTTCCTGCTGCTGCTCCTGCTTTC
CTCTCTTCTCGCTTTAAATGATTGTTAGCAAGTTAGATTTTCCTGGAGCTTCGGAAGAAATGAAAATGGAAACATGATGAAGATATAGTC
ACTGAATCAATGAGAAAAATAATGAACATATGAATACCACCTAAAAATACACTGAATAAAGTACACCATATAGCATTATTTTTATAGGAA
ATATTTCATGTCCCTTAAATATTCTTTGTTAGTTATAGGGATGGACAGTTTATGTTAAGCACTTAGCTTAAACAATCCGTTTATATTAGC
ACTGTATCCCTTGTGCCATCCAACATTTTGTATGTTTTTGTAAACAGTTCATATACAGTACATTTCTGTACTGCTTTCTTTAATGTATAC
ATGCCTTGTTTAACTTGGAATCTATTATTATTAATCAATTGACTATTAAATCTGGTTAAATAGTTCACCTGGATTAACAGTATTGTTGGA
CAGTCCTAAAAATGGCCAGATTGTGGAACAGCTGTTGAATGTAATACTTCCAAAATGTACATATCTTTCCCCACGTCTGTTTCACTGGTT
CGTTCATTTGTTTGTTTCTTAAAGTCAGGTGCTCTGTCAGACTAACCTAGAGAGCTGTTATGGTAGAGAAAGTTATCATATGTGTGTGGC
ATGAAATCAAGAATACACCTATGAAGTTAGTCCATATACTTTGCAACTCCTTAGAGTACTTTTTTCCTTAATTAAGGAAGTAGTCCTTGC
ACTTCTAATCTTACATAGCATCCATACTTAGAATTTGGCATATCATCTGGGATTTTGCCAATATACGTCAAAGCCCTTTAAGAGTCATGG
TAAGGAGATGGGTGAAGGAAAATTTAGCAACAGGTAATTGAAGTCCTATTGGATATTTCATGTTTAAATAGATATTCTATATTAAACACT
AATTTAAATGTAATAAAGGCCAAAGGCCTCTGTATGAAATTGGATTTAAACTTTCTTATTTTAGGGAATAAAACATTATTGATCAAACAG
TATCTGTTCTAACCTAAAATTATAGGTAGGGCAGGCTAAGTGAACAGCATTGAGTATTTTCTGAATCCCTCATGATAATTTATAGCCACA
TACTGCTTCCTTTGACTTCAGGAATGATCAGTTTTCATAATGGCCACTGGGCCTGCTTAGATTGCAGTATTCATTATCTGCATCTAATTT
GGTAGTTTCCACAATCGTATTTGATGAAAGAAACTTCAGTCCCCATTATTACCTGTGTCTTTGCCAAGCTGCCTAGCATACATCAGTATG
TAATGTAAAAGACATATGAGCAAGAAAAAAGTGATTTAACTTACCTCATCAAGAATGTGCCCCTACAGGCCGGGCGCAGTGGCTCACGCC
TGTAATCCCAGCATTTTGGGAGGCCGAGGCAGGTGGATCACCTGAGGTCAGGAGTTTGAGACCAGCCTGGCCAACATGGTGAAACCCCGT
CTCTACTAAAAAATACAAAAATTAGCTGGGCATGGTGGCGTGCACCTGTAATCCTAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTG
AACCTGGGAGGTGGTGGTTGCAGTGAGCCAAGATCACACCATTGCACTCCAGCCTGGGTGACAGAGTGAGACTCTGTCTCAAGAAGGAAA
AAAAAAAAAAAGAATGTACTCATACAGATTTTTGTTAGTCATCATGTAATAAGCCATTTATATCAGAAACCTTTTTTCCTGCCACAGAAG
CTTTAAATTTTCCCCTAAGAGTACAAAGCCAAGAGAGTGTGGTTTATCTAAATGTCCTGAAATCCACTTGTCATTCCTTAATTTCTCCTC
TATGCAATTAAAGAGAAAGGGGAAATCTATAACATTTCTTTTGCCCAAGTGACACAAAAATGATTACTGCATAGAAATCAAATGTAAGTT
TAGCTTCTAAATGAAATAATATATAGGAGGGATATCAGAATGTCTAGATAGAGAAAGTATTTTCAAATTCTTGAATATATGGATGCTATT
AAAAGCTGCTTTCCATTGCCTGGAAAGAGAGCTTTTTTCCCTCCTCTATTCAGTGTTTCAAACTTTGGTCATCTCAAATTATTGTCACTT
TTAAAATGTTAATGTCATTCTGAGCAGAAATAGATATATTTTCAGATTTTTTTACACTGATGCTACTCCGTAATTGCTTAGGAGTATTGT
CCATCATAGTATTTTAGAACTAGAAGTAAACACATAAATCCTTATAAATTACCCAATCCAACTTTCTCATATTGCATGTAGAGAACCTGA
GACACATATCAAAGTCTAGAATCCTTAACTTCTCCCCATTTTGTTTTTTTCCGCCTCATCACACCATGCTGCCTTTCCCTCATATGATCA
CCAACCAGTAGCTGAGTTCAAAAACTACATATTTCTTGGGCAGTCCTCTACTGGTATGTGATGCCAACTTTTATTTCTTTCGAAGATAAT
TGCCTTCTTTGCCTAGCCAAGCAGCCAATTTTATTGGAGAAAAGCAAGTTATATGTTCACAAAATGGAAGGCTTTCTACCTAAATTTATT
TCATCTGTGGTCCTCTTATTCTCTTCCATTGCTTTTGACATACAGTGGAAAAACTTGGCCAACGATGTGCTCTAAATATAGTGCTTGTGT
TGGGTTAACTTTTCCATTAATTTCTCAACATCAATTATTCAGGCCCCTACAGTTGTGGTATTGAGGCCCCTAAAGGCTTCTGCCTTTCAC
CAATTAGTGCTGCCAGTTACTGAGGCTTCTCCCAAAAGGTATCAGTCCAGTCTTAAAGATATTTCATTGTGAAAGAAGAAACTAAACTAT
CAGGCCTCTTTTACAAAATGAGAGATTGAATTTAAGCTTGTCAAGCACGTACTGGAAGGTATGAATTACACTACCATGTGTTTTGTATCT
TCCCTTTCAAGTGATGATGTTAAATGAAGGTAAGTTTTTCATCCTTTTTTAATTTTTGTTTTTTATAAATCATTTCAGCTTTTTCTGGTT
TATAGAGGTGTCTTATTTCTAATGCAACAGACCCCCAACTTTAACAGATTTGATATGGATGCATTTATTCACAAGCAACCCCAAAAGTCC
AAAAATGTAATAATTTTGACAAGGCCCAAAGTTGAGATGCTATGAAGCTTGTGTGTGTGAAAAGTCAGTTATGATTGTCTGGAGAGAAGC
TGTGGTGTGTATGCTGTAGAGTTTCCACATTTCACATGCAGTGTACTCCAAAAAGCGGGTTTGGGTCAACCATTTCCCATCTCTTTTTAA
GAAGTGACTGCTGTTGGGGCCAGGGGACATCATGGGAGGTGGGGCTGTCCAGTTAGCTGTGCCCTGCACCTTCAGCCCAGGAAAGATTTG
AACAGAGCAAAGGCTTCAAGAGAGGGCAGAATGTATTCGGCAGAAAAGGGACTCAGGTAAGCCCAGCCTGGGATGAGAGCAGAAAAGCAT
TCAAGATTTGCAGGCCTTGCTATGGATGCGCTTAATCACCATGGAGGCCAGCAATACCCATCTCAGCATGGCTTTGATATTCTCTACTTC
CTGGCCTTTAAAAATGACCTATAATTTTTCAGTTTGCTTTACTATATTTTATAAAGAAAATTCTATCTTATGGTTGATTGAGCATTGAGA
CTTATGAAGGCATTAGGATAGATAGCTCAGGAATGTAAAGGTTCAGAAAAGGTCTGTTTTCTCAGATTAACAAATATGATGGATTCCATG
GCTGACCTTGGTGCTTAAACCAGGAGGTTTCAATCTAGTCCTAGAGTTGTGTCCCTCTGAAAGGCCCAATGCCATGTAACTAACTTTAAA
CTGGATATATACTTTGAGCCTTACTTAATTCACAGATAAGTTGACTTAACTCAGTATTTTTATTTCAATTAATGAAAACAGTCCTCTTTT
CAACCCCAGGTTGCTTACATTTTGCTGGTCTCCCCAAGTGACCATTGGTGGAGACCAATTAATGAAGGAATGAAATTCACTTTATTGGGA
CTGTGGTATTCAACAGAGCCACACTTAACCACTTTTTCCAATGAAGAATCTCCAGAATGATAATGCCCAAATATGGATGGCCAAGAAGAA
TTTGTATCTACGGTGTGCTTTATGTGTTTTTGACACTGCTGTATTCTGTGTGATCAAGTGATTTGCAGCTGGTTCCAATGTGACTGAGTG
TTCTCAAAGATTTCTAGTAACTAAGTCAACTTAATTTTCTTAAGCCTGGTATTACTATCAGCCTCACATTTACCACTTTGATTCTAGTTT
TTTAACTGTTCATAACAGGGCATACCGAGGGTTGGGATGAGAGCCTACTTCCTACCTCTTAAGGCACTTTCCTCATTATTTTGCCATATA
ATCTTGAACTGCATGATAAGCTGTTTAAATGTCCATGACTTCTCCCAGAGCAACTAGCAAAGTATATGACATTTTGAATAGAGATTAGTG
GAAAGGAAAATGTAGAGATTTAAGTTCAGAGGTACAAACCTCAATAAAACCTCCTTAGAGCACATACCATGAGTAGAGTATATGTAAACG
TATATGAGAAGAGAGTCGCTATAATAGTCCTCTCTAAGTAGATTAGTTCATTGTCTAATGGAAGTGAACATCTTTACTCCTGTTATCACC
ATAGTACTGAATGAACTGTATAATGAGTTTTTCAAACAAGTATTTAAAATAGAACTTTCACGTACAAAGCAAGGGCATAAAGATTTTGGT
TTGTGTTTCTGTAAGTGTAGTTTACCATCTAAAGCTTTGGTTTTTAATTTTAAAAAAAGCTTCAAGGTATTGCCATTCCTTAGCATCCTT
ATTGATTATGGGTGATGAGTTTTTAACTCTTAAAATCATATACGTGTATTAGTTTATCTTAACTGTTGCCCTAAGCAAAAGGGAAGGTAT
ACACCTAAGGGATGTACTTATTTTGCATTTTTGGTCATGGGTGGGAATGGGGTGGGTGCCTACTTAAATAGTTTTTAAAAAAGAAAAAAA
TCACAAATATTTTTCTACTGTTATATATGATCTTCCTTTATACTAGTTTCTCTCTAGTAAGGCATGCCAGAAGCCCAAGATACCATATCA
TGAATTCTTACATATTGTACCTTTTGTTGGTGGTTAAATCGCATCAGATGCTTGGCATTGCTGCCATAATTATAAAATGCTTGTAAAGGA
TCAAATATCACTAAATACTTTAAATTGTTTTACTTAAGAGTCTAATCTGGGAAGTTTTCAAATCATACTATTAATGTGTAATCTAAGCTC
TTCAGATGTATCCATGAATAATCCTGGAACAATATTGCTTGTATTCCTGTCATAGAACAGGTTTTGTAATCTTTAAAAGAAATGAAAATT

>81498_81498_6_SH3KBP1-RPS6KA3_SH3KBP1_chrX_19854243_ENST00000397821_RPS6KA3_chrX_20227522_ENST00000379565_length(amino acids)=752AA_BP=54
MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGS
FGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEE
DVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLM
FEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPAT
GRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKR
CIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVE
YLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPF
ANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYS

--------------------------------------------------------------
>81498_81498_7_SH3KBP1-RPS6KA3_SH3KBP1_chrX_19854243_ENST00000397821_RPS6KA3_chrX_20227522_ENST00000540702_length(transcript)=2688nt_BP=453nt
CGCAATTTCCACTCGCGGGGAGCAGGAAACCCGGCGCAGCCGGGCGCATTGGGCCGCGATGCAACAGCAGCAGCAGGAGTCGCCCCGGGG
CAGCAGCGGCAGCAGCAGCAGAGGCAGCAGCGGGCGGCGCTGAGCCGCCGCCGCCGCCACTGAGGAAGAAGCCGGCCCAGCCGCCGCCGC
GTCCGGACCCTCGCGCCTGGATCCCAGCGCCCCGATCCCGGCGCCCCAACCCCCACGCCCGCCTCCGCCAACTTTCACGCTGCCTCGGCG
GCCCGGCCCGGCTCGACGCCAATGGTGGAGGCCATAGTGGAGTTTGACTACCAGGCCCAGCACGATGATGAGCTGACGATCAGCGTGGGT
GAAATCATCACCAACATCAGGAAGGAGGATGGAGGCTGGTGGGAGGGACAGATCAACGGCAGGAGAGGTTTGTTCCCTGACAACTTTGTA
AGAGAAGAAGTCAGTATCAAAGAAATTGCAATCACACATCATGTAAAGGAAGGACATGAAAAGGCAGATCCTTCCCAGTTTGAACTTTTA
AAAGTATTAGGGCAGGGATCATTTGGAAAGGTTTTCTTAGTTAAAAAAATCTCAGGCTCTGATGCTAGGCAGCTTTATGCCATGAAGGTA
TTGAAGAAGGCCACACTGAAAGTTCGAGACCGAGTTCGGACAAAAATGGAACGTGATATCTTGGTAGAGGTTAATCATCCTTTTATTGTC
AAGTTGCATTATGCTTTTCAAACTGAAGGGAAGTTGTATCTTATTTTGGATTTTCTCAGGGGAGGAGATTTGTTTACACGCTTATCCAAA
GAGGTGATGTTCACAGAAGAAGATGTCAAATTCTACTTGGCTGAACTTGCACTTGCTTTAGACCATCTACATAGCCTGGGAATAATTTAT
AGAGACTTAAAACCAGAAAATATACTTCTTGATGAAGAAGGTCACATCAAGTTAACAGATTTCGGCCTAAGTAAAGAGTCTATTGACCAT
GAAAAGAAGGCATATTCTTTTTGTGGAACTGTGGAGTATATGGCTCCAGAAGTAGTTAATCGTCGAGGTCATACTCAGAGTGCTGACTGG
TGGTCTTTTGGTGTGTTAATGTTTGAAATGCTTACTGGTACACTCCCTTTCCAAGGAAAAGATCGAAAAGAAACAATGACTATGATTCTT
AAAGCCAAACTTGGAATGCCACAGTTTTTGAGTCCTGAAGCGCAGAGTCTTTTACGAATGCTTTTCAAGCGAAATCCTGCAAACAGATTA
GGTGCAGGACCAGATGGAGTTGAAGAAATTAAAAGACATTCATTTTTCTCAACGATAGACTGGAATAAACTGTATAGAAGAGAAATTCAT
CCGCCATTTAAACCTGCAACGGGCAGGCCTGAAGATACATTCTATTTTGATCCTGAGTTTACTGCAAAAACTCCCAAAGATTCACCTGGC
ATTCCACCTAGTGCTAATGCACATCAGCTTTTTCGGGGGTTTAGTTTTGTTGCTATTACCTCAGATGATGAAAGCCAAGCTATGCAGACA
GTTGGTGTACATTCAATTGTTCAGTTACACAGGAACAGTATTCAGTTTACTGATGGATATGAAGTAAAAGAAGATATTGGAGTTGGCTCC
TACTCTGTTTGCAAGAGATGTATACATAAAGCTACAAACATGGAGTTTGCAGTGAAGATTATTGATAAAAGCAAGAGAGACCCAACAGAA
GAAATTGAAATTCTTCTTCGTTATGGACAGCATCCAAACATTATCACTCTAAAGGATGTATATGATGATGGAAAGTATGTGTATGTAGTA
ACAGAACTTATGAAAGGAGGTGAATTGCTGGATAAAATTCTTAGACAAAAATTTTTCTCTGAACGAGAGGCCAGTGCTGTCCTGTTCACT
ATAACTAAAACCGTTGAATATCTTCACGCACAAGGGGTGGTTCATAGAGACTTGAAACCTAGCAACATTCTTTATGTGGATGAATCTGGT
AATCCGGAATCTATTCGAATTTGTGATTTTGGCTTTGCAAAACAGCTGAGAGCGGAAAATGGTCTTCTCATGACTCCTTGTTACACTGCA
AATTTTGTTGCACCAGAGGTTTTAAAAAGACAAGGCTATGATGCTGCTTGTGATATATGGAGTCTTGGTGTCCTACTCTATACAATGCTT
ACCGGTTACACTCCATTTGCAAATGGTCCTGATGATACACCAGAGGAAATATTGGCACGAATAGGTAGCGGAAAATTCTCACTCAGTGGT
GGTTACTGGAATTCTGTTTCAGACACAGCAAAGGACCTGGTGTCAAAGATGCTTCATGTAGACCCTCATCAGAGACTGACTGCTGCTCTT
GTGCTCAGACATCCTTGGATCGTCCACTGGGACCAACTGCCACAATACCAACTAAACAGACAGGATGCACCACATCTAGTAAAGGGTGCC
ATGGCAGCTACATATTCTGCTTTGAACCGTAATCAGTCACCAGTTTTGGAACCAGTAGGCCGCTCTACTCTTGCTCAGCGGAGAGGTATT
AAAAAAATCACCTCAACAGCCCTGTGAAGTGACCTCAGTGAGATATTTGGTACCATGGTGTAAGCTGATAGCACAAGTTCTGGCGACAGG

>81498_81498_7_SH3KBP1-RPS6KA3_SH3KBP1_chrX_19854243_ENST00000397821_RPS6KA3_chrX_20227522_ENST00000540702_length(amino acids)=751AA_BP=54
MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGS
FGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEE
DVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLM
FEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPAT
GRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQLHRNSIQFTDGYEVKEDIGVGSYSVCKRC
IHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVEY
LHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPFA
NGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYSA

--------------------------------------------------------------
>81498_81498_8_SH3KBP1-RPS6KA3_SH3KBP1_chrX_19854243_ENST00000397821_RPS6KA3_chrX_20227522_ENST00000544447_length(transcript)=2982nt_BP=453nt
CGCAATTTCCACTCGCGGGGAGCAGGAAACCCGGCGCAGCCGGGCGCATTGGGCCGCGATGCAACAGCAGCAGCAGGAGTCGCCCCGGGG
CAGCAGCGGCAGCAGCAGCAGAGGCAGCAGCGGGCGGCGCTGAGCCGCCGCCGCCGCCACTGAGGAAGAAGCCGGCCCAGCCGCCGCCGC
GTCCGGACCCTCGCGCCTGGATCCCAGCGCCCCGATCCCGGCGCCCCAACCCCCACGCCCGCCTCCGCCAACTTTCACGCTGCCTCGGCG
GCCCGGCCCGGCTCGACGCCAATGGTGGAGGCCATAGTGGAGTTTGACTACCAGGCCCAGCACGATGATGAGCTGACGATCAGCGTGGGT
GAAATCATCACCAACATCAGGAAGGAGGATGGAGGCTGGTGGGAGGGACAGATCAACGGCAGGAGAGGTTTGTTCCCTGACAACTTTGTA
AGAGAAGAAGTCAGTATCAAAGAAATTGCAATCACACATCATGTAAAGGAAGGACATGAAAAGGCAGATCCTTCCCAGTTTGAACTTTTA
AAAGTATTAGGGCAGGGATCATTTGGAAAGGTTTTCTTAGTTAAAAAAATCTCAGGCTCTGATGCTAGGCAGCTTTATGCCATGAAGGTA
TTGAAGAAGGCCACACTGAAAGTTCGAGACCGAGTTCGGACAAAAATGGAACGTGATATCTTGGTAGAGGTTAATCATCCTTTTATTGTC
AAGTTGCATTATGCTTTTCAAACTGAAGGGAAGTTGTATCTTATTTTGGATTTTCTCAGGGGAGGAGATTTGTTTACACGCTTATCCAAA
GAGGTGATGTTCACAGAAGAAGATGTCAAATTCTACTTGGCTGAACTTGCACTTGCTTTAGACCATCTACATAGCCTGGGAATAATTTAT
AGAGACTTAAAACCAGAAAATATACTTCTTGATGAAGAAGGTCACATCAAGTTAACAGATTTCGGCCTAAGTAAAGAGTCTATTGACCAT
GAAAAGAAGGCATATTCTTTTTGTGGAACTGTGGAGTATATGGCTCCAGAAGTAGTTAATCGTCGAGGTCATACTCAGAGTGCTGACTGG
TGGTCTTTTGGTGTGTTAATGTTTGAAATGCTTACTGGTACACTCCCTTTCCAAGGAAAAGATCGAAAAGAAACAATGACTATGATTCTT
AAAGCCAAACTTGGAATGCCACAGTTTTTGAGTCCTGAAGCGCAGAGTCTTTTACGAATGCTTTTCAAGCGAAATCCTGCAAACAGATTA
GGTGCAGGACCAGATGGAGTTGAAGAAATTAAAAGACATTCATTTTTCTCAACGATAGACTGGAATAAACTGTATAGAAGAGAAATTCAT
CCGCCATTTAAACCTGCAACGGGCAGGCCTGAAGATACATTCTATTTTGATCCTGAGTTTACTGCAAAAACTCCCAAAGATTCACCTGGC
ATTCCACCTAGTGCTAATGCACATCAGCTTTTTCGGGGGTTTAGTTTTGTTGCTATTACCTCAGATGATGAAAGCCAAGCTATGCAGACA
GTTGGTGTACATTCAATTGTTCAGCAGTTACACAGGAACAGTATTCAGTTTACTGATGGATATGAAGTAAAAGAAGATATTGGAGTTGGC
TCCTACTCTGTTTGCAAGAGATGTATACATAAAGCTACAAACATGGAGTTTGCAGTGAAGATTATTGATAAAAGCAAGAGAGACCCAACA
GAAGAAATTGAAATTCTTCTTCGTTATGGACAGCATCCAAACATTATCACTCTAAAGGATGTATATGATGATGGAAAGTATGTGTATGTA
GTAACAGAACTTATGAAAGGAGGTGAATTGCTGGATAAAATTCTTAGACAAAAATTTTTCTCTGAACGAGAGGCCAGTGCTGTCCTGTTC
ACTATAACTAAAACCGTTGAATATCTTCACGCACAAGGGGTGGTTCATAGAGACTTGAAACCTAGCAACATTCTTTATGTGGATGAATCT
GGTAATCCGGAATCTATTCGAATTTGTGATTTTGGCTTTGCAAAACAGCTGAGAGCGGAAAATGGTCTTCTCATGACTCCTTGTTACACT
GCAAATTTTGTTGCACCAGAGGTTTTAAAAAGACAAGGCTATGATGCTGCTTGTGATATATGGAGTCTTGGTGTCCTACTCTATACAATG
CTTACCGGTTACACTCCATTTGCAAATGGTCCTGATGATACACCAGAGGAAATATTGGCACGAATAGGTAGCGGAAAATTCTCACTCAGT
GGTGGTTACTGGAATTCTGTTTCAGACACAGCAAAGGACCTGGTGTCAAAGATGCTTCATGTAGACCCTCATCAGAGACTGACTGCTGCT
CTTGTGCTCAGACATCCTTGGATCGTCCACTGGGACCAACTGCCACAATACCAACTAAACAGACAGGATGCACCACATCTAGTAAAGGGT
GCCATGGCAGCTACATATTCTGCTTTGAACCGTAATCAGTCACCAGTTTTGGAACCAGTAGGCCGCTCTACTCTTGCTCAGCGGAGAGGT
ATTAAAAAAATCACCTCAACAGCCCTGTGAAGTGACCTCAGTGAGATATTTGGTACCATGGTGTAAGCTGATAGCACAAGTTCTGGCGAC
AGGTAGCACGTATCTGAGAGACACCTGCAAGCACACACTGTCCCAGCTGGTACCCATAATGCTGCTGTTCCTGCTGCTGCTCCTGCTTTC
CTCTCTTCTCGCTTTAAATGATTGTTAGCAAGTTAGATTTTCCTGGAGCTTCGGAAGAAATGAAAATGGAAACATGATGAAGATATAGTC
ACTGAATCAATGAGAAAAATAATGAACATATGAATACCACCTAAAAATACACTGAATAAAGTACACCATATAGCATTATTTTTATAGGAA
ATATTTCATGTCCCTTAAATATTCTTTGTTAGTTATAGGGATGGACAGTTTATGTTAAGCACTTAGCTTAAACAATCCGTTTATATTAGC

>81498_81498_8_SH3KBP1-RPS6KA3_SH3KBP1_chrX_19854243_ENST00000397821_RPS6KA3_chrX_20227522_ENST00000544447_length(amino acids)=752AA_BP=54
MVEAIVEFDYQAQHDDELTISVGEIITNIRKEDGGWWEGQINGRRGLFPDNFVREEVSIKEIAITHHVKEGHEKADPSQFELLKVLGQGS
FGKVFLVKKISGSDARQLYAMKVLKKATLKVRDRVRTKMERDILVEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEE
DVKFYLAELALALDHLHSLGIIYRDLKPENILLDEEGHIKLTDFGLSKESIDHEKKAYSFCGTVEYMAPEVVNRRGHTQSADWWSFGVLM
FEMLTGTLPFQGKDRKETMTMILKAKLGMPQFLSPEAQSLLRMLFKRNPANRLGAGPDGVEEIKRHSFFSTIDWNKLYRREIHPPFKPAT
GRPEDTFYFDPEFTAKTPKDSPGIPPSANAHQLFRGFSFVAITSDDESQAMQTVGVHSIVQQLHRNSIQFTDGYEVKEDIGVGSYSVCKR
CIHKATNMEFAVKIIDKSKRDPTEEIEILLRYGQHPNIITLKDVYDDGKYVYVVTELMKGGELLDKILRQKFFSEREASAVLFTITKTVE
YLHAQGVVHRDLKPSNILYVDESGNPESIRICDFGFAKQLRAENGLLMTPCYTANFVAPEVLKRQGYDAACDIWSLGVLLYTMLTGYTPF
ANGPDDTPEEILARIGSGKFSLSGGYWNSVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWIVHWDQLPQYQLNRQDAPHLVKGAMAATYS

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Fusion Gene PPI Analysis for SH3KBP1-RPS6KA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SH3KBP1-RPS6KA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SH3KBP1-RPS6KA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource