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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SH3RF1-SPOCK3 (FusionGDB2 ID:81528)

Fusion Gene Summary for SH3RF1-SPOCK3

check button Fusion gene summary
Fusion gene informationFusion gene name: SH3RF1-SPOCK3
Fusion gene ID: 81528
HgeneTgene
Gene symbol

SH3RF1

SPOCK3

Gene ID

57630

50859

Gene nameSH3 domain containing ring finger 1SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
SynonymsPOSH|RNF142|SH3MD2HSAJ1454|TES-3|TICN3
Cytomap

4q32.3-q33

4q32.3

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase SH3RF1RING-type E3 ubiquitin transferase SH3RF1SH3 domain-containing RING finger protein 1SH3 multiple domains 2SH3 multiple domains protein 2plenty of SH3 domainsplenty of SH3sputative E3 ubiquitin-protein ligase SH3RF1testican-3SPARC/osteonectin, cwcv and kazal like domains proteoglycan 3sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000284637, ENST00000508685, 
ENST00000421836, ENST00000502330, 
ENST00000507137, ENST00000510741, 
ENST00000511269, ENST00000512648, 
ENST00000512681, ENST00000534949, 
ENST00000535728, ENST00000541354, 
ENST00000541637, ENST00000357154, 
ENST00000357545, ENST00000504953, 
ENST00000506886, ENST00000511531, 
Fusion gene scores* DoF score10 X 8 X 5=4005 X 5 X 5=125
# samples 106
** MAII scorelog2(10/400*10)=-2
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/125*10)=-1.05889368905357
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SH3RF1 [Title/Abstract] AND SPOCK3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSH3RF1(170057469)-SPOCK3(167810395), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SH3RF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SPOCK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4COADTCGA-AZ-6607-01ASH3RF1chr4

170057469

-SPOCK3chr4

167810395

-


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Fusion Gene ORF analysis for SH3RF1-SPOCK3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000284637ENST00000421836SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5CDS-5UTRENST00000284637ENST00000502330SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5CDS-5UTRENST00000284637ENST00000507137SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5CDS-5UTRENST00000284637ENST00000510741SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5CDS-5UTRENST00000284637ENST00000511269SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5CDS-5UTRENST00000284637ENST00000512648SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5CDS-5UTRENST00000284637ENST00000512681SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5CDS-5UTRENST00000284637ENST00000534949SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5CDS-5UTRENST00000284637ENST00000535728SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5CDS-5UTRENST00000284637ENST00000541354SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5CDS-5UTRENST00000284637ENST00000541637SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5UTR-3CDSENST00000508685ENST00000357154SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5UTR-3CDSENST00000508685ENST00000357545SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5UTR-3CDSENST00000508685ENST00000504953SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5UTR-3CDSENST00000508685ENST00000506886SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5UTR-3CDSENST00000508685ENST00000511531SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5UTR-5UTRENST00000508685ENST00000421836SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5UTR-5UTRENST00000508685ENST00000502330SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5UTR-5UTRENST00000508685ENST00000507137SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5UTR-5UTRENST00000508685ENST00000510741SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5UTR-5UTRENST00000508685ENST00000511269SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5UTR-5UTRENST00000508685ENST00000512648SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5UTR-5UTRENST00000508685ENST00000512681SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5UTR-5UTRENST00000508685ENST00000534949SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5UTR-5UTRENST00000508685ENST00000535728SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5UTR-5UTRENST00000508685ENST00000541354SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
5UTR-5UTRENST00000508685ENST00000541637SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
In-frameENST00000284637ENST00000357154SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
In-frameENST00000284637ENST00000357545SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
In-frameENST00000284637ENST00000504953SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
In-frameENST00000284637ENST00000506886SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-
In-frameENST00000284637ENST00000511531SH3RF1chr4

170057469

-SPOCK3chr4

167810395

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000284637SH3RF1chr4170057469-ENST00000357154SPOCK3chr4167810395-377514103422237631
ENST00000284637SH3RF1chr4170057469-ENST00000357545SPOCK3chr4167810395-377214103422237631
ENST00000284637SH3RF1chr4170057469-ENST00000504953SPOCK3chr4167810395-377214103422237631
ENST00000284637SH3RF1chr4170057469-ENST00000511531SPOCK3chr4167810395-377114103422237631
ENST00000284637SH3RF1chr4170057469-ENST00000506886SPOCK3chr4167810395-377114103422237631

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000284637ENST00000357154SH3RF1chr4170057469-SPOCK3chr4167810395-0.0003016360.9996984
ENST00000284637ENST00000357545SH3RF1chr4170057469-SPOCK3chr4167810395-0.0003026680.9996973
ENST00000284637ENST00000504953SH3RF1chr4170057469-SPOCK3chr4167810395-0.0003026680.9996973
ENST00000284637ENST00000511531SH3RF1chr4170057469-SPOCK3chr4167810395-0.000301250.99969876
ENST00000284637ENST00000506886SH3RF1chr4170057469-SPOCK3chr4167810395-0.000301250.99969876

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Fusion Genomic Features for SH3RF1-SPOCK3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SH3RF1-SPOCK3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:170057469/chr4:167810395)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSH3RF1chr4:170057469chr4:167810395ENST00000284637-512134_193356889.0DomainSH3 1
HgeneSH3RF1chr4:170057469chr4:167810395ENST00000284637-512196_259356889.0DomainSH3 2
HgeneSH3RF1chr4:170057469chr4:167810395ENST00000284637-51212_53356889.0Zinc fingerRING-type
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000357154512394_436161437.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000357545411394_436158434.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000421836512394_436110386.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000502330512394_436161437.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000504953411394_436158434.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000506886512394_436161437.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000510741410394_436158394.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000511269310394_436158434.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000511531512394_436161437.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr4:170057469chr4:167810395ENST0000051264848394_436158314.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr4:170057469chr4:167810395ENST0000051268118394_43663339.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr4:170057469chr4:167810395ENST0000053494918394_43665341.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000541354310394_43641317.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr4:170057469chr4:167810395ENST0000054163707394_43663339.0Compositional biasNote=Asp-rich
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000357154512314_380161437.0DomainThyroglobulin type-1
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000357545411314_380158434.0DomainThyroglobulin type-1
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000421836512133_185110386.0DomainKazal-like
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000421836512314_380110386.0DomainThyroglobulin type-1
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000502330512314_380161437.0DomainThyroglobulin type-1
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000504953411314_380158434.0DomainThyroglobulin type-1
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000506886512314_380161437.0DomainThyroglobulin type-1
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000510741410314_380158394.0DomainThyroglobulin type-1
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000511269310314_380158434.0DomainThyroglobulin type-1
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000511531512314_380161437.0DomainThyroglobulin type-1
TgeneSPOCK3chr4:170057469chr4:167810395ENST0000051264848314_380158314.0DomainThyroglobulin type-1
TgeneSPOCK3chr4:170057469chr4:167810395ENST0000051268118133_18563339.0DomainKazal-like
TgeneSPOCK3chr4:170057469chr4:167810395ENST0000051268118314_38063339.0DomainThyroglobulin type-1
TgeneSPOCK3chr4:170057469chr4:167810395ENST0000053494918133_18565341.0DomainKazal-like
TgeneSPOCK3chr4:170057469chr4:167810395ENST0000053494918314_38065341.0DomainThyroglobulin type-1
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000541354310133_18541317.0DomainKazal-like
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000541354310314_38041317.0DomainThyroglobulin type-1
TgeneSPOCK3chr4:170057469chr4:167810395ENST0000054163707133_18563339.0DomainKazal-like
TgeneSPOCK3chr4:170057469chr4:167810395ENST0000054163707314_38063339.0DomainThyroglobulin type-1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSH3RF1chr4:170057469chr4:167810395ENST00000284637-512397_403356889.0Compositional biasNote=Poly-Pro
HgeneSH3RF1chr4:170057469chr4:167810395ENST00000284637-512417_424356889.0Compositional biasNote=Poly-Ala
HgeneSH3RF1chr4:170057469chr4:167810395ENST00000284637-512657_662356889.0Compositional biasNote=Poly-Ala
HgeneSH3RF1chr4:170057469chr4:167810395ENST00000284637-512445_506356889.0DomainSH3 3
HgeneSH3RF1chr4:170057469chr4:167810395ENST00000284637-512829_888356889.0DomainSH3 4
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000357154512133_185161437.0DomainKazal-like
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000357545411133_185158434.0DomainKazal-like
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000502330512133_185161437.0DomainKazal-like
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000504953411133_185158434.0DomainKazal-like
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000506886512133_185161437.0DomainKazal-like
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000510741410133_185158394.0DomainKazal-like
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000511269310133_185158434.0DomainKazal-like
TgeneSPOCK3chr4:170057469chr4:167810395ENST00000511531512133_185161437.0DomainKazal-like
TgeneSPOCK3chr4:170057469chr4:167810395ENST0000051264848133_185158314.0DomainKazal-like


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Fusion Gene Sequence for SH3RF1-SPOCK3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81528_81528_1_SH3RF1-SPOCK3_SH3RF1_chr4_170057469_ENST00000284637_SPOCK3_chr4_167810395_ENST00000357154_length(transcript)=3775nt_BP=1410nt
CGCCCCGGGCGCCGGCTGCGTCCCGGCCTCCTCCTCCTCTTCCTCCGCCCTCCTTGGCTGGGAAAGTGGGAGGCGGCGGCGGCGGCGTGG
TGTGTGTGCGCGCGTGAGGGGGGCAGCAGAGAGGAGTCTCCCGGTGCCGCCGCGGCGTCAGAGACACTGCGAGCGGCGAGCGCGGTGGGG
CCGCATCTGCATCAGCCGCCGCAGCCGCTGCGGGGCCGCGAACAAAGAGGAGGAGCCGAGGCGCGAGAGCAAAGTCTGAAATGGATGTTA
CATGAGTCATTTTAAGGGATGCACACAACTATGAACATTTCTGAAGATTTTTTCTCAGTAAAGTAGATAAAGATGGATGAATCAGCCTTG
TTGGATCTTTTGGAGTGTCCGGTGTGTCTAGAGCGCCTTGATGCTTCTGCGAAGGTCTTGCCTTGCCAGCATACGTTTTGCAAGCGATGT
TTGCTGGGGATCGTAGGTTCTCGAAATGAACTCAGATGTCCCGAGTGCAGGACTCTTGTTGGCTCGGGTGTCGAGGAGCTTCCCAGTAAC
ATCTTGCTGGTCAGACTTCTGGATGGCATCAAACAGAGGCCTTGGAAACCTGGTCCTGGTGGGGGAAGTGGGACCAACTGCACAAATGCA
TTAAGGTCTCAGAGCAGCACTGTGGCTAATTGTAGCTCAAAAGATCTGCAGAGCTCCCAGGGCGGACAGCAGCCTCGGGTGCAATCCTGG
AGCCCCCCAGTGAGGGGTATACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCTGGAGACCTTAAATTCAGC
AAAGGTGACATCATCATTTTGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCATGGCTTTTTCCCCACCAAC
TTTGTGCAGATTATTAAACCGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAAGACAAGGAAGCAGACAAA
GATTGCCTTCCATTTGCAAAGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGAATGCTGGCAGACAAAATA
GGAATATTTCCAATTTCATATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCTGTGCCAGGAGTTGATGCT
GGAGAATGTTCCTCGGCAGCAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAAAAGCGGCACTCCTTCACT
TCCCTCACTATGGCCAACAAGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTCCTCATCAGCTCCAGCAAC
CCCACTGCTGCTGCACGGATCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGTGCAAACTAGAATATCAGGCATGTGTCTTA
GGAAAACAGATCTCAGTCAAATGTGAAGGACATTGCCCATGTCCTTCAGATAAGCCCACCAGTACAAGCAGAAATGTTAAGAGAGCATGC
AGTGACCTGGAGTTCAGGGAAGTGGCAAACAGATTGCGGGACTGGTTCAAGGCCCTTCATGAAAGTGGAAGTCAAAACAAGAAGACAAAA
ACATTGCTGAGGCCTGAGAGAAGCAGATTCGATACCAGCATCTTGCCAATTTGCAAGGACTCACTTGGCTGGATGTTTAACAGACTTGAT
ACAAACTATGACCTGCTATTGGACCAGTCAGAGCTCAGAAGCATTTACCTTGATAAGAATGAACAGTGTACCAAGGCATTCTTCAATTCT
TGTGACACATACAAGGACAGTTTAATATCTAATAATGAGTGGTGCTACTGCTTCCAGAGACAGCAAGACCCACCTTGCCAGACTGAGCTC
AGCAATATTCAGAAGCGGCAAGGGGTAAAGAAGCTCCTAGGACAGTATATCCCCCTGTGTGATGAAGATGGTTACTACAAGCCAACACAA
TGTCATGGCAGTGTTGGACAGTGCTGGTGTGTTGACAGATATGGAAATGAAGTCATGGGATCCAGAATAAATGGTGTTGCAGATTGTGCT
ATAGATTTTGAGATCTCCGGAGATTTTGCTAGTGGCGATTTTCATGAATGGACTGATGATGAGGATGATGAAGACGATATTATGAATGAT
GAAGATGAAATTGAAGATGATGATGAAGATGAAGGGGATGATGATGATGGTGGTGATGACCATGATGTATACATTTGATTGATGACAGTT
GAAATCAATAAATTCTACATTTCTAATATTTACAAAAATGATAGCCTATTTAAAATTATCTTCTTCCCCAATAACAAAATGATTCTAAAC
CTCACATATATTTTGTATAATTATTTGAAAAATTGCAGCTAAAGTTATAGAACTTTATGTTTAAATAAGAATCATTTGCTTTGAGTTTTT
ATATTCCTTACACAAAAAGAAAATACATATGCAGTCTAGTCAGACAAAATAAAGTTTTGAAGTGCTACTATAATAAGTTTTTCACGAGAA
CAAACTTTGTAAATCTTCCATAAGCAAAATGACAGCTAGTGCTTGGGATCGTACATGTTAATTTTCTGAAAGATAATTCTAAGTGAAATT
TAAAATAAATAAATTTTTAATGACCTGGGTCTTAAGGATTTAGGAAAAATATGCATGCTTTAATTGCATTTCCAAAGTAGCATCTTGCTA
GACCTAGTTGAGTCAGGATAACAGAGAGATACCACATGGCAAGAAAAACAAAGTGACAATTGTAGAGTCCTCAATTGTGTTTACATTAAT
AGTGGTGTTTTTACCTATGAAATTATTCTGGATCTAATAGGACATTTTACAAAATGGCAAGTATGGAAAACCATGGATTCTGAAAGTTAA
AAATTTAGTTGTTCTCCCCAATGTGTATTTTAATTTGGATGGCAGTCTCATGCAGATTTTTTAAAAGATTCTTTAATAACATGATTTGTT
TGCCTTTCTAGATTTCTTTATCTTTCTGACCAGCAACTTAGGGAGCAGAATTTAAATTAGGAAGACAAAGGGAAAGATTCATTTAAACCA
TATTTTTACAAAGTTTGTCATTTGCCCCAAGGTCAAATTTTAAATTCTTAATTTTCATTTTATTTCCCATTTTAGGTAAAAGTTTGCATT
TAATCTTAGAATTATGTTATTTTTGTTAGTAGTGTGGAAACTTAGAGAACTTATTGTATGGTGCCTTGCAAAAATAGAGATAGAAAGATT
TTAGCATGCATACCAATATAGTATATTACGCAATATATAAGCACACCTAATTAACAGATTAATATCAGTAAAGGTATTGCTGCTGGAATG
AAGAAAATGGGATACGTTTGTTTCTTTTTTTCTATTGTTACATAATTGCCATGTGGACTTGTTTATGATTATTGTGTAGAGTAGCATTTA
AGATTTAACTGTAGCAAAAATTACTTTAACCGCTGTATTTAAGTTAGCATGTTAATTAATTGTGTAGACATTTTGGCACACCATCACTTT
TAACTATATCATACCAATGGTTTTGTGCCCATAATAAAAATGGAAAAACCTGTTGAATGTTACGTATTGGTATCTTTAATTTCAACAGTG
GGTAAACTGGTTTCCCAGTATACAATTCATTGAAAGCAAAATTGATTAATTATTTCCATTTAATTTATACACACTCAATACAAAATTTAA

>81528_81528_1_SH3RF1-SPOCK3_SH3RF1_chr4_170057469_ENST00000284637_SPOCK3_chr4_167810395_ENST00000357154_length(amino acids)=631AA_BP=355
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVEELPSNILLVRLLDGIKQRPWKPGPGGGSG
TNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH
GFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPP
VPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQCKLE
YQACVLGKQISVKCEGHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSRFDTSILPICKDSLGW
MFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDG
YYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHDVY

--------------------------------------------------------------
>81528_81528_2_SH3RF1-SPOCK3_SH3RF1_chr4_170057469_ENST00000284637_SPOCK3_chr4_167810395_ENST00000357545_length(transcript)=3772nt_BP=1410nt
CGCCCCGGGCGCCGGCTGCGTCCCGGCCTCCTCCTCCTCTTCCTCCGCCCTCCTTGGCTGGGAAAGTGGGAGGCGGCGGCGGCGGCGTGG
TGTGTGTGCGCGCGTGAGGGGGGCAGCAGAGAGGAGTCTCCCGGTGCCGCCGCGGCGTCAGAGACACTGCGAGCGGCGAGCGCGGTGGGG
CCGCATCTGCATCAGCCGCCGCAGCCGCTGCGGGGCCGCGAACAAAGAGGAGGAGCCGAGGCGCGAGAGCAAAGTCTGAAATGGATGTTA
CATGAGTCATTTTAAGGGATGCACACAACTATGAACATTTCTGAAGATTTTTTCTCAGTAAAGTAGATAAAGATGGATGAATCAGCCTTG
TTGGATCTTTTGGAGTGTCCGGTGTGTCTAGAGCGCCTTGATGCTTCTGCGAAGGTCTTGCCTTGCCAGCATACGTTTTGCAAGCGATGT
TTGCTGGGGATCGTAGGTTCTCGAAATGAACTCAGATGTCCCGAGTGCAGGACTCTTGTTGGCTCGGGTGTCGAGGAGCTTCCCAGTAAC
ATCTTGCTGGTCAGACTTCTGGATGGCATCAAACAGAGGCCTTGGAAACCTGGTCCTGGTGGGGGAAGTGGGACCAACTGCACAAATGCA
TTAAGGTCTCAGAGCAGCACTGTGGCTAATTGTAGCTCAAAAGATCTGCAGAGCTCCCAGGGCGGACAGCAGCCTCGGGTGCAATCCTGG
AGCCCCCCAGTGAGGGGTATACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCTGGAGACCTTAAATTCAGC
AAAGGTGACATCATCATTTTGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCATGGCTTTTTCCCCACCAAC
TTTGTGCAGATTATTAAACCGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAAGACAAGGAAGCAGACAAA
GATTGCCTTCCATTTGCAAAGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGAATGCTGGCAGACAAAATA
GGAATATTTCCAATTTCATATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCTGTGCCAGGAGTTGATGCT
GGAGAATGTTCCTCGGCAGCAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAAAAGCGGCACTCCTTCACT
TCCCTCACTATGGCCAACAAGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTCCTCATCAGCTCCAGCAAC
CCCACTGCTGCTGCACGGATCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGTGCAAACTAGAATATCAGGCATGTGTCTTA
GGAAAACAGATCTCAGTCAAATGTGAAGGACATTGCCCATGTCCTTCAGATAAGCCCACCAGTACAAGCAGAAATGTTAAGAGAGCATGC
AGTGACCTGGAGTTCAGGGAAGTGGCAAACAGATTGCGGGACTGGTTCAAGGCCCTTCATGAAAGTGGAAGTCAAAACAAGAAGACAAAA
ACATTGCTGAGGCCTGAGAGAAGCAGATTCGATACCAGCATCTTGCCAATTTGCAAGGACTCACTTGGCTGGATGTTTAACAGACTTGAT
ACAAACTATGACCTGCTATTGGACCAGTCAGAGCTCAGAAGCATTTACCTTGATAAGAATGAACAGTGTACCAAGGCATTCTTCAATTCT
TGTGACACATACAAGGACAGTTTAATATCTAATAATGAGTGGTGCTACTGCTTCCAGAGACAGCAAGACCCACCTTGCCAGACTGAGCTC
AGCAATATTCAGAAGCGGCAAGGGGTAAAGAAGCTCCTAGGACAGTATATCCCCCTGTGTGATGAAGATGGTTACTACAAGCCAACACAA
TGTCATGGCAGTGTTGGACAGTGCTGGTGTGTTGACAGATATGGAAATGAAGTCATGGGATCCAGAATAAATGGTGTTGCAGATTGTGCT
ATAGATTTTGAGATCTCCGGAGATTTTGCTAGTGGCGATTTTCATGAATGGACTGATGATGAGGATGATGAAGACGATATTATGAATGAT
GAAGATGAAATTGAAGATGATGATGAAGATGAAGGGGATGATGATGATGGTGGTGATGACCATGATGTATACATTTGATTGATGACAGTT
GAAATCAATAAATTCTACATTTCTAATATTTACAAAAATGATAGCCTATTTAAAATTATCTTCTTCCCCAATAACAAAATGATTCTAAAC
CTCACATATATTTTGTATAATTATTTGAAAAATTGCAGCTAAAGTTATAGAACTTTATGTTTAAATAAGAATCATTTGCTTTGAGTTTTT
ATATTCCTTACACAAAAAGAAAATACATATGCAGTCTAGTCAGACAAAATAAAGTTTTGAAGTGCTACTATAATAAGTTTTTCACGAGAA
CAAACTTTGTAAATCTTCCATAAGCAAAATGACAGCTAGTGCTTGGGATCGTACATGTTAATTTTCTGAAAGATAATTCTAAGTGAAATT
TAAAATAAATAAATTTTTAATGACCTGGGTCTTAAGGATTTAGGAAAAATATGCATGCTTTAATTGCATTTCCAAAGTAGCATCTTGCTA
GACCTAGTTGAGTCAGGATAACAGAGAGATACCACATGGCAAGAAAAACAAAGTGACAATTGTAGAGTCCTCAATTGTGTTTACATTAAT
AGTGGTGTTTTTACCTATGAAATTATTCTGGATCTAATAGGACATTTTACAAAATGGCAAGTATGGAAAACCATGGATTCTGAAAGTTAA
AAATTTAGTTGTTCTCCCCAATGTGTATTTTAATTTGGATGGCAGTCTCATGCAGATTTTTTAAAAGATTCTTTAATAACATGATTTGTT
TGCCTTTCTAGATTTCTTTATCTTTCTGACCAGCAACTTAGGGAGCAGAATTTAAATTAGGAAGACAAAGGGAAAGATTCATTTAAACCA
TATTTTTACAAAGTTTGTCATTTGCCCCAAGGTCAAATTTTAAATTCTTAATTTTCATTTTATTTCCCATTTTAGGTAAAAGTTTGCATT
TAATCTTAGAATTATGTTATTTTTGTTAGTAGTGTGGAAACTTAGAGAACTTATTGTATGGTGCCTTGCAAAAATAGAGATAGAAAGATT
TTAGCATGCATACCAATATAGTATATTACGCAATATATAAGCACACCTAATTAACAGATTAATATCAGTAAAGGTATTGCTGCTGGAATG
AAGAAAATGGGATACGTTTGTTTCTTTTTTTCTATTGTTACATAATTGCCATGTGGACTTGTTTATGATTATTGTGTAGAGTAGCATTTA
AGATTTAACTGTAGCAAAAATTACTTTAACCGCTGTATTTAAGTTAGCATGTTAATTAATTGTGTAGACATTTTGGCACACCATCACTTT
TAACTATATCATACCAATGGTTTTGTGCCCATAATAAAAATGGAAAAACCTGTTGAATGTTACGTATTGGTATCTTTAATTTCAACAGTG
GGTAAACTGGTTTCCCAGTATACAATTCATTGAAAGCAAAATTGATTAATTATTTCCATTTAATTTATACACACTCAATACAAAATTTAA

>81528_81528_2_SH3RF1-SPOCK3_SH3RF1_chr4_170057469_ENST00000284637_SPOCK3_chr4_167810395_ENST00000357545_length(amino acids)=631AA_BP=355
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVEELPSNILLVRLLDGIKQRPWKPGPGGGSG
TNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH
GFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPP
VPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQCKLE
YQACVLGKQISVKCEGHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSRFDTSILPICKDSLGW
MFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDG
YYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHDVY

--------------------------------------------------------------
>81528_81528_3_SH3RF1-SPOCK3_SH3RF1_chr4_170057469_ENST00000284637_SPOCK3_chr4_167810395_ENST00000504953_length(transcript)=3772nt_BP=1410nt
CGCCCCGGGCGCCGGCTGCGTCCCGGCCTCCTCCTCCTCTTCCTCCGCCCTCCTTGGCTGGGAAAGTGGGAGGCGGCGGCGGCGGCGTGG
TGTGTGTGCGCGCGTGAGGGGGGCAGCAGAGAGGAGTCTCCCGGTGCCGCCGCGGCGTCAGAGACACTGCGAGCGGCGAGCGCGGTGGGG
CCGCATCTGCATCAGCCGCCGCAGCCGCTGCGGGGCCGCGAACAAAGAGGAGGAGCCGAGGCGCGAGAGCAAAGTCTGAAATGGATGTTA
CATGAGTCATTTTAAGGGATGCACACAACTATGAACATTTCTGAAGATTTTTTCTCAGTAAAGTAGATAAAGATGGATGAATCAGCCTTG
TTGGATCTTTTGGAGTGTCCGGTGTGTCTAGAGCGCCTTGATGCTTCTGCGAAGGTCTTGCCTTGCCAGCATACGTTTTGCAAGCGATGT
TTGCTGGGGATCGTAGGTTCTCGAAATGAACTCAGATGTCCCGAGTGCAGGACTCTTGTTGGCTCGGGTGTCGAGGAGCTTCCCAGTAAC
ATCTTGCTGGTCAGACTTCTGGATGGCATCAAACAGAGGCCTTGGAAACCTGGTCCTGGTGGGGGAAGTGGGACCAACTGCACAAATGCA
TTAAGGTCTCAGAGCAGCACTGTGGCTAATTGTAGCTCAAAAGATCTGCAGAGCTCCCAGGGCGGACAGCAGCCTCGGGTGCAATCCTGG
AGCCCCCCAGTGAGGGGTATACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCTGGAGACCTTAAATTCAGC
AAAGGTGACATCATCATTTTGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCATGGCTTTTTCCCCACCAAC
TTTGTGCAGATTATTAAACCGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAAGACAAGGAAGCAGACAAA
GATTGCCTTCCATTTGCAAAGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGAATGCTGGCAGACAAAATA
GGAATATTTCCAATTTCATATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCTGTGCCAGGAGTTGATGCT
GGAGAATGTTCCTCGGCAGCAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAAAAGCGGCACTCCTTCACT
TCCCTCACTATGGCCAACAAGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTCCTCATCAGCTCCAGCAAC
CCCACTGCTGCTGCACGGATCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGTGCAAACTAGAATATCAGGCATGTGTCTTA
GGAAAACAGATCTCAGTCAAATGTGAAGGACATTGCCCATGTCCTTCAGATAAGCCCACCAGTACAAGCAGAAATGTTAAGAGAGCATGC
AGTGACCTGGAGTTCAGGGAAGTGGCAAACAGATTGCGGGACTGGTTCAAGGCCCTTCATGAAAGTGGAAGTCAAAACAAGAAGACAAAA
ACATTGCTGAGGCCTGAGAGAAGCAGATTCGATACCAGCATCTTGCCAATTTGCAAGGACTCACTTGGCTGGATGTTTAACAGACTTGAT
ACAAACTATGACCTGCTATTGGACCAGTCAGAGCTCAGAAGCATTTACCTTGATAAGAATGAACAGTGTACCAAGGCATTCTTCAATTCT
TGTGACACATACAAGGACAGTTTAATATCTAATAATGAGTGGTGCTACTGCTTCCAGAGACAGCAAGACCCACCTTGCCAGACTGAGCTC
AGCAATATTCAGAAGCGGCAAGGGGTAAAGAAGCTCCTAGGACAGTATATCCCCCTGTGTGATGAAGATGGTTACTACAAGCCAACACAA
TGTCATGGCAGTGTTGGACAGTGCTGGTGTGTTGACAGATATGGAAATGAAGTCATGGGATCCAGAATAAATGGTGTTGCAGATTGTGCT
ATAGATTTTGAGATCTCCGGAGATTTTGCTAGTGGCGATTTTCATGAATGGACTGATGATGAGGATGATGAAGACGATATTATGAATGAT
GAAGATGAAATTGAAGATGATGATGAAGATGAAGGGGATGATGATGATGGTGGTGATGACCATGATGTATACATTTGATTGATGACAGTT
GAAATCAATAAATTCTACATTTCTAATATTTACAAAAATGATAGCCTATTTAAAATTATCTTCTTCCCCAATAACAAAATGATTCTAAAC
CTCACATATATTTTGTATAATTATTTGAAAAATTGCAGCTAAAGTTATAGAACTTTATGTTTAAATAAGAATCATTTGCTTTGAGTTTTT
ATATTCCTTACACAAAAAGAAAATACATATGCAGTCTAGTCAGACAAAATAAAGTTTTGAAGTGCTACTATAATAAGTTTTTCACGAGAA
CAAACTTTGTAAATCTTCCATAAGCAAAATGACAGCTAGTGCTTGGGATCGTACATGTTAATTTTCTGAAAGATAATTCTAAGTGAAATT
TAAAATAAATAAATTTTTAATGACCTGGGTCTTAAGGATTTAGGAAAAATATGCATGCTTTAATTGCATTTCCAAAGTAGCATCTTGCTA
GACCTAGTTGAGTCAGGATAACAGAGAGATACCACATGGCAAGAAAAACAAAGTGACAATTGTAGAGTCCTCAATTGTGTTTACATTAAT
AGTGGTGTTTTTACCTATGAAATTATTCTGGATCTAATAGGACATTTTACAAAATGGCAAGTATGGAAAACCATGGATTCTGAAAGTTAA
AAATTTAGTTGTTCTCCCCAATGTGTATTTTAATTTGGATGGCAGTCTCATGCAGATTTTTTAAAAGATTCTTTAATAACATGATTTGTT
TGCCTTTCTAGATTTCTTTATCTTTCTGACCAGCAACTTAGGGAGCAGAATTTAAATTAGGAAGACAAAGGGAAAGATTCATTTAAACCA
TATTTTTACAAAGTTTGTCATTTGCCCCAAGGTCAAATTTTAAATTCTTAATTTTCATTTTATTTCCCATTTTAGGTAAAAGTTTGCATT
TAATCTTAGAATTATGTTATTTTTGTTAGTAGTGTGGAAACTTAGAGAACTTATTGTATGGTGCCTTGCAAAAATAGAGATAGAAAGATT
TTAGCATGCATACCAATATAGTATATTACGCAATATATAAGCACACCTAATTAACAGATTAATATCAGTAAAGGTATTGCTGCTGGAATG
AAGAAAATGGGATACGTTTGTTTCTTTTTTTCTATTGTTACATAATTGCCATGTGGACTTGTTTATGATTATTGTGTAGAGTAGCATTTA
AGATTTAACTGTAGCAAAAATTACTTTAACCGCTGTATTTAAGTTAGCATGTTAATTAATTGTGTAGACATTTTGGCACACCATCACTTT
TAACTATATCATACCAATGGTTTTGTGCCCATAATAAAAATGGAAAAACCTGTTGAATGTTACGTATTGGTATCTTTAATTTCAACAGTG
GGTAAACTGGTTTCCCAGTATACAATTCATTGAAAGCAAAATTGATTAATTATTTCCATTTAATTTATACACACTCAATACAAAATTTAA

>81528_81528_3_SH3RF1-SPOCK3_SH3RF1_chr4_170057469_ENST00000284637_SPOCK3_chr4_167810395_ENST00000504953_length(amino acids)=631AA_BP=355
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVEELPSNILLVRLLDGIKQRPWKPGPGGGSG
TNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH
GFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPP
VPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQCKLE
YQACVLGKQISVKCEGHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSRFDTSILPICKDSLGW
MFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDG
YYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHDVY

--------------------------------------------------------------
>81528_81528_4_SH3RF1-SPOCK3_SH3RF1_chr4_170057469_ENST00000284637_SPOCK3_chr4_167810395_ENST00000506886_length(transcript)=3771nt_BP=1410nt
CGCCCCGGGCGCCGGCTGCGTCCCGGCCTCCTCCTCCTCTTCCTCCGCCCTCCTTGGCTGGGAAAGTGGGAGGCGGCGGCGGCGGCGTGG
TGTGTGTGCGCGCGTGAGGGGGGCAGCAGAGAGGAGTCTCCCGGTGCCGCCGCGGCGTCAGAGACACTGCGAGCGGCGAGCGCGGTGGGG
CCGCATCTGCATCAGCCGCCGCAGCCGCTGCGGGGCCGCGAACAAAGAGGAGGAGCCGAGGCGCGAGAGCAAAGTCTGAAATGGATGTTA
CATGAGTCATTTTAAGGGATGCACACAACTATGAACATTTCTGAAGATTTTTTCTCAGTAAAGTAGATAAAGATGGATGAATCAGCCTTG
TTGGATCTTTTGGAGTGTCCGGTGTGTCTAGAGCGCCTTGATGCTTCTGCGAAGGTCTTGCCTTGCCAGCATACGTTTTGCAAGCGATGT
TTGCTGGGGATCGTAGGTTCTCGAAATGAACTCAGATGTCCCGAGTGCAGGACTCTTGTTGGCTCGGGTGTCGAGGAGCTTCCCAGTAAC
ATCTTGCTGGTCAGACTTCTGGATGGCATCAAACAGAGGCCTTGGAAACCTGGTCCTGGTGGGGGAAGTGGGACCAACTGCACAAATGCA
TTAAGGTCTCAGAGCAGCACTGTGGCTAATTGTAGCTCAAAAGATCTGCAGAGCTCCCAGGGCGGACAGCAGCCTCGGGTGCAATCCTGG
AGCCCCCCAGTGAGGGGTATACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCTGGAGACCTTAAATTCAGC
AAAGGTGACATCATCATTTTGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCATGGCTTTTTCCCCACCAAC
TTTGTGCAGATTATTAAACCGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAAGACAAGGAAGCAGACAAA
GATTGCCTTCCATTTGCAAAGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGAATGCTGGCAGACAAAATA
GGAATATTTCCAATTTCATATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCTGTGCCAGGAGTTGATGCT
GGAGAATGTTCCTCGGCAGCAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAAAAGCGGCACTCCTTCACT
TCCCTCACTATGGCCAACAAGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTCCTCATCAGCTCCAGCAAC
CCCACTGCTGCTGCACGGATCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGTGCAAACTAGAATATCAGGCATGTGTCTTA
GGAAAACAGATCTCAGTCAAATGTGAAGGACATTGCCCATGTCCTTCAGATAAGCCCACCAGTACAAGCAGAAATGTTAAGAGAGCATGC
AGTGACCTGGAGTTCAGGGAAGTGGCAAACAGATTGCGGGACTGGTTCAAGGCCCTTCATGAAAGTGGAAGTCAAAACAAGAAGACAAAA
ACATTGCTGAGGCCTGAGAGAAGCAGATTCGATACCAGCATCTTGCCAATTTGCAAGGACTCACTTGGCTGGATGTTTAACAGACTTGAT
ACAAACTATGACCTGCTATTGGACCAGTCAGAGCTCAGAAGCATTTACCTTGATAAGAATGAACAGTGTACCAAGGCATTCTTCAATTCT
TGTGACACATACAAGGACAGTTTAATATCTAATAATGAGTGGTGCTACTGCTTCCAGAGACAGCAAGACCCACCTTGCCAGACTGAGCTC
AGCAATATTCAGAAGCGGCAAGGGGTAAAGAAGCTCCTAGGACAGTATATCCCCCTGTGTGATGAAGATGGTTACTACAAGCCAACACAA
TGTCATGGCAGTGTTGGACAGTGCTGGTGTGTTGACAGATATGGAAATGAAGTCATGGGATCCAGAATAAATGGTGTTGCAGATTGTGCT
ATAGATTTTGAGATCTCCGGAGATTTTGCTAGTGGCGATTTTCATGAATGGACTGATGATGAGGATGATGAAGACGATATTATGAATGAT
GAAGATGAAATTGAAGATGATGATGAAGATGAAGGGGATGATGATGATGGTGGTGATGACCATGATGTATACATTTGATTGATGACAGTT
GAAATCAATAAATTCTACATTTCTAATATTTACAAAAATGATAGCCTATTTAAAATTATCTTCTTCCCCAATAACAAAATGATTCTAAAC
CTCACATATATTTTGTATAATTATTTGAAAAATTGCAGCTAAAGTTATAGAACTTTATGTTTAAATAAGAATCATTTGCTTTGAGTTTTT
ATATTCCTTACACAAAAAGAAAATACATATGCAGTCTAGTCAGACAAAATAAAGTTTTGAAGTGCTACTATAATAAGTTTTTCACGAGAA
CAAACTTTGTAAATCTTCCATAAGCAAAATGACAGCTAGTGCTTGGGATCGTACATGTTAATTTTCTGAAAGATAATTCTAAGTGAAATT
TAAAATAAATAAATTTTTAATGACCTGGGTCTTAAGGATTTAGGAAAAATATGCATGCTTTAATTGCATTTCCAAAGTAGCATCTTGCTA
GACCTAGTTGAGTCAGGATAACAGAGAGATACCACATGGCAAGAAAAACAAAGTGACAATTGTAGAGTCCTCAATTGTGTTTACATTAAT
AGTGGTGTTTTTACCTATGAAATTATTCTGGATCTAATAGGACATTTTACAAAATGGCAAGTATGGAAAACCATGGATTCTGAAAGTTAA
AAATTTAGTTGTTCTCCCCAATGTGTATTTTAATTTGGATGGCAGTCTCATGCAGATTTTTTAAAAGATTCTTTAATAACATGATTTGTT
TGCCTTTCTAGATTTCTTTATCTTTCTGACCAGCAACTTAGGGAGCAGAATTTAAATTAGGAAGACAAAGGGAAAGATTCATTTAAACCA
TATTTTTACAAAGTTTGTCATTTGCCCCAAGGTCAAATTTTAAATTCTTAATTTTCATTTTATTTCCCATTTTAGGTAAAAGTTTGCATT
TAATCTTAGAATTATGTTATTTTTGTTAGTAGTGTGGAAACTTAGAGAACTTATTGTATGGTGCCTTGCAAAAATAGAGATAGAAAGATT
TTAGCATGCATACCAATATAGTATATTACGCAATATATAAGCACACCTAATTAACAGATTAATATCAGTAAAGGTATTGCTGCTGGAATG
AAGAAAATGGGATACGTTTGTTTCTTTTTTTCTATTGTTACATAATTGCCATGTGGACTTGTTTATGATTATTGTGTAGAGTAGCATTTA
AGATTTAACTGTAGCAAAAATTACTTTAACCGCTGTATTTAAGTTAGCATGTTAATTAATTGTGTAGACATTTTGGCACACCATCACTTT
TAACTATATCATACCAATGGTTTTGTGCCCATAATAAAAATGGAAAAACCTGTTGAATGTTACGTATTGGTATCTTTAATTTCAACAGTG
GGTAAACTGGTTTCCCAGTATACAATTCATTGAAAGCAAAATTGATTAATTATTTCCATTTAATTTATACACACTCAATACAAAATTTAA

>81528_81528_4_SH3RF1-SPOCK3_SH3RF1_chr4_170057469_ENST00000284637_SPOCK3_chr4_167810395_ENST00000506886_length(amino acids)=631AA_BP=355
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVEELPSNILLVRLLDGIKQRPWKPGPGGGSG
TNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH
GFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPP
VPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQCKLE
YQACVLGKQISVKCEGHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSRFDTSILPICKDSLGW
MFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDG
YYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHDVY

--------------------------------------------------------------
>81528_81528_5_SH3RF1-SPOCK3_SH3RF1_chr4_170057469_ENST00000284637_SPOCK3_chr4_167810395_ENST00000511531_length(transcript)=3771nt_BP=1410nt
CGCCCCGGGCGCCGGCTGCGTCCCGGCCTCCTCCTCCTCTTCCTCCGCCCTCCTTGGCTGGGAAAGTGGGAGGCGGCGGCGGCGGCGTGG
TGTGTGTGCGCGCGTGAGGGGGGCAGCAGAGAGGAGTCTCCCGGTGCCGCCGCGGCGTCAGAGACACTGCGAGCGGCGAGCGCGGTGGGG
CCGCATCTGCATCAGCCGCCGCAGCCGCTGCGGGGCCGCGAACAAAGAGGAGGAGCCGAGGCGCGAGAGCAAAGTCTGAAATGGATGTTA
CATGAGTCATTTTAAGGGATGCACACAACTATGAACATTTCTGAAGATTTTTTCTCAGTAAAGTAGATAAAGATGGATGAATCAGCCTTG
TTGGATCTTTTGGAGTGTCCGGTGTGTCTAGAGCGCCTTGATGCTTCTGCGAAGGTCTTGCCTTGCCAGCATACGTTTTGCAAGCGATGT
TTGCTGGGGATCGTAGGTTCTCGAAATGAACTCAGATGTCCCGAGTGCAGGACTCTTGTTGGCTCGGGTGTCGAGGAGCTTCCCAGTAAC
ATCTTGCTGGTCAGACTTCTGGATGGCATCAAACAGAGGCCTTGGAAACCTGGTCCTGGTGGGGGAAGTGGGACCAACTGCACAAATGCA
TTAAGGTCTCAGAGCAGCACTGTGGCTAATTGTAGCTCAAAAGATCTGCAGAGCTCCCAGGGCGGACAGCAGCCTCGGGTGCAATCCTGG
AGCCCCCCAGTGAGGGGTATACCTCAGTTACCATGTGCCAAAGCATTATACAACTATGAAGGAAAAGAGCCTGGAGACCTTAAATTCAGC
AAAGGTGACATCATCATTTTGCGAAGACAAGTGGATGAAAATTGGTACCATGGGGAAGTCAATGGAATCCATGGCTTTTTCCCCACCAAC
TTTGTGCAGATTATTAAACCGTTACCTCAGCCCCCACCTCAGTGCAAAGCACTTTATGACTTTGAAGTGAAAGACAAGGAAGCAGACAAA
GATTGCCTTCCATTTGCAAAGGATGATGTTCTGACTGTGATCCGAAGAGTGGATGAAAACTGGGCTGAAGGAATGCTGGCAGACAAAATA
GGAATATTTCCAATTTCATATGTTGAGTTTAACTCGGCTGCTAAGCAGCTGATAGAATGGGATAAGCCTCCTGTGCCAGGAGTTGATGCT
GGAGAATGTTCCTCGGCAGCAGCCCAGAGCAGCACTGCCCCAAAGCACTCCGACACCAAGAAGAACACCAAAAAGCGGCACTCCTTCACT
TCCCTCACTATGGCCAACAAGTCCTCCCAGGCATCCCAGAACCGCCACTCCATGGAGATCAGCCCCCCTGTCCTCATCAGCTCCAGCAAC
CCCACTGCTGCTGCACGGATCAGCGAGCTGTCTGGGCTCTCCTGCAGTGCCCCTTCTCAGTGCAAACTAGAATATCAGGCATGTGTCTTA
GGAAAACAGATCTCAGTCAAATGTGAAGGACATTGCCCATGTCCTTCAGATAAGCCCACCAGTACAAGCAGAAATGTTAAGAGAGCATGC
AGTGACCTGGAGTTCAGGGAAGTGGCAAACAGATTGCGGGACTGGTTCAAGGCCCTTCATGAAAGTGGAAGTCAAAACAAGAAGACAAAA
ACATTGCTGAGGCCTGAGAGAAGCAGATTCGATACCAGCATCTTGCCAATTTGCAAGGACTCACTTGGCTGGATGTTTAACAGACTTGAT
ACAAACTATGACCTGCTATTGGACCAGTCAGAGCTCAGAAGCATTTACCTTGATAAGAATGAACAGTGTACCAAGGCATTCTTCAATTCT
TGTGACACATACAAGGACAGTTTAATATCTAATAATGAGTGGTGCTACTGCTTCCAGAGACAGCAAGACCCACCTTGCCAGACTGAGCTC
AGCAATATTCAGAAGCGGCAAGGGGTAAAGAAGCTCCTAGGACAGTATATCCCCCTGTGTGATGAAGATGGTTACTACAAGCCAACACAA
TGTCATGGCAGTGTTGGACAGTGCTGGTGTGTTGACAGATATGGAAATGAAGTCATGGGATCCAGAATAAATGGTGTTGCAGATTGTGCT
ATAGATTTTGAGATCTCCGGAGATTTTGCTAGTGGCGATTTTCATGAATGGACTGATGATGAGGATGATGAAGACGATATTATGAATGAT
GAAGATGAAATTGAAGATGATGATGAAGATGAAGGGGATGATGATGATGGTGGTGATGACCATGATGTATACATTTGATTGATGACAGTT
GAAATCAATAAATTCTACATTTCTAATATTTACAAAAATGATAGCCTATTTAAAATTATCTTCTTCCCCAATAACAAAATGATTCTAAAC
CTCACATATATTTTGTATAATTATTTGAAAAATTGCAGCTAAAGTTATAGAACTTTATGTTTAAATAAGAATCATTTGCTTTGAGTTTTT
ATATTCCTTACACAAAAAGAAAATACATATGCAGTCTAGTCAGACAAAATAAAGTTTTGAAGTGCTACTATAATAAGTTTTTCACGAGAA
CAAACTTTGTAAATCTTCCATAAGCAAAATGACAGCTAGTGCTTGGGATCGTACATGTTAATTTTCTGAAAGATAATTCTAAGTGAAATT
TAAAATAAATAAATTTTTAATGACCTGGGTCTTAAGGATTTAGGAAAAATATGCATGCTTTAATTGCATTTCCAAAGTAGCATCTTGCTA
GACCTAGTTGAGTCAGGATAACAGAGAGATACCACATGGCAAGAAAAACAAAGTGACAATTGTAGAGTCCTCAATTGTGTTTACATTAAT
AGTGGTGTTTTTACCTATGAAATTATTCTGGATCTAATAGGACATTTTACAAAATGGCAAGTATGGAAAACCATGGATTCTGAAAGTTAA
AAATTTAGTTGTTCTCCCCAATGTGTATTTTAATTTGGATGGCAGTCTCATGCAGATTTTTTAAAAGATTCTTTAATAACATGATTTGTT
TGCCTTTCTAGATTTCTTTATCTTTCTGACCAGCAACTTAGGGAGCAGAATTTAAATTAGGAAGACAAAGGGAAAGATTCATTTAAACCA
TATTTTTACAAAGTTTGTCATTTGCCCCAAGGTCAAATTTTAAATTCTTAATTTTCATTTTATTTCCCATTTTAGGTAAAAGTTTGCATT
TAATCTTAGAATTATGTTATTTTTGTTAGTAGTGTGGAAACTTAGAGAACTTATTGTATGGTGCCTTGCAAAAATAGAGATAGAAAGATT
TTAGCATGCATACCAATATAGTATATTACGCAATATATAAGCACACCTAATTAACAGATTAATATCAGTAAAGGTATTGCTGCTGGAATG
AAGAAAATGGGATACGTTTGTTTCTTTTTTTCTATTGTTACATAATTGCCATGTGGACTTGTTTATGATTATTGTGTAGAGTAGCATTTA
AGATTTAACTGTAGCAAAAATTACTTTAACCGCTGTATTTAAGTTAGCATGTTAATTAATTGTGTAGACATTTTGGCACACCATCACTTT
TAACTATATCATACCAATGGTTTTGTGCCCATAATAAAAATGGAAAAACCTGTTGAATGTTACGTATTGGTATCTTTAATTTCAACAGTG
GGTAAACTGGTTTCCCAGTATACAATTCATTGAAAGCAAAATTGATTAATTATTTCCATTTAATTTATACACACTCAATACAAAATTTAA

>81528_81528_5_SH3RF1-SPOCK3_SH3RF1_chr4_170057469_ENST00000284637_SPOCK3_chr4_167810395_ENST00000511531_length(amino acids)=631AA_BP=355
MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVEELPSNILLVRLLDGIKQRPWKPGPGGGSG
TNCTNALRSQSSTVANCSSKDLQSSQGGQQPRVQSWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVNGIH
GFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPP
VPGVDAGECSSAAAQSSTAPKHSDTKKNTKKRHSFTSLTMANKSSQASQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQCKLE
YQACVLGKQISVKCEGHCPCPSDKPTSTSRNVKRACSDLEFREVANRLRDWFKALHESGSQNKKTKTLLRPERSRFDTSILPICKDSLGW
MFNRLDTNYDLLLDQSELRSIYLDKNEQCTKAFFNSCDTYKDSLISNNEWCYCFQRQQDPPCQTELSNIQKRQGVKKLLGQYIPLCDEDG
YYKPTQCHGSVGQCWCVDRYGNEVMGSRINGVADCAIDFEISGDFASGDFHEWTDDEDDEDDIMNDEDEIEDDDEDEGDDDDGGDDHDVY

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Fusion Gene PPI Analysis for SH3RF1-SPOCK3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSH3RF1chr4:170057469chr4:167810395ENST00000284637-512440_543356.0889.0AKT2
HgeneSH3RF1chr4:170057469chr4:167810395ENST00000284637-512292_362356.0889.0RAC1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SH3RF1-SPOCK3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SH3RF1-SPOCK3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource