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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SH3YL1-MTHFD1L (FusionGDB2 ID:81539)

Fusion Gene Summary for SH3YL1-MTHFD1L

Fusion gene summary

Fusion gene information	Fusion gene name: SH3YL1-MTHFD1L
	Fusion gene ID: 81539
		Hgene	Tgene
	Gene symbol	SH3YL1	MTHFD1L
	Gene ID	26751	25902
	Gene name	SH3 and SYLF domain containing 1	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
	Synonyms	RAY	FTHFSDC1\|MTC1THFS\|dJ292B18.2
	Cytomap	2p25.3	6q25.1
	Type of gene	protein-coding	protein-coding
	Description	SH3 domain-containing YSC84-like protein 1SH3 domain containing, Ysc84-like 1	monofunctional C1-tetrahydrofolate synthase, mitochondrial10-formyl-THF synthetaseformyltetrahydrofolate synthetase domain containing 1
	Modification date	20200313	20200313
	UniProtAcc	.	Q6UB35
	Ensembl transtripts involved in fusion gene	ENST00000356150, ENST00000403657, ENST00000403658, ENST00000403712, ENST00000405430, ENST00000415006, ENST00000468321, ENST00000402632,	ENST00000367307, ENST00000478643, ENST00000367321,
Fusion gene scores	* DoF score	3 X 5 X 3=45	14 X 17 X 13=3094
	# samples	4	27
	** MAII score	log2(4/45*10)=-0.169925001442312 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(27/3094*10)=-3.51844188439821 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SH3YL1 [Title/Abstract] AND MTHFD1L [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SH3YL1(229966)-MTHFD1L(151243341), # samples:2
Anticipated loss of major functional domain due to fusion event.	SH3YL1-MTHFD1L seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. SH3YL1-MTHFD1L seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	MTHFD1L	GO:0006760	folic acid-containing compound metabolic process	12937168
Tgene	MTHFD1L	GO:0009257	10-formyltetrahydrofolate biosynthetic process	12937168
Tgene	MTHFD1L	GO:0015942	formate metabolic process	16171773

Fusion gene breakpoints across SH3YL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MTHFD1L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	SARC	TCGA-X2-A95T-01A	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+

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Fusion Gene ORF analysis for SH3YL1-MTHFD1L

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000356150	ENST00000367307	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
5CDS-intron	ENST00000356150	ENST00000478643	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
5CDS-intron	ENST00000403657	ENST00000367307	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
5CDS-intron	ENST00000403657	ENST00000478643	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
5CDS-intron	ENST00000403658	ENST00000367307	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
5CDS-intron	ENST00000403658	ENST00000478643	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
5CDS-intron	ENST00000403712	ENST00000367307	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
5CDS-intron	ENST00000403712	ENST00000478643	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
5CDS-intron	ENST00000405430	ENST00000367307	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
5CDS-intron	ENST00000405430	ENST00000478643	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
5CDS-intron	ENST00000415006	ENST00000367307	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
5CDS-intron	ENST00000415006	ENST00000478643	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
5UTR-3CDS	ENST00000468321	ENST00000367321	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
5UTR-intron	ENST00000468321	ENST00000367307	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
5UTR-intron	ENST00000468321	ENST00000478643	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
Frame-shift	ENST00000356150	ENST00000367321	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
Frame-shift	ENST00000403658	ENST00000367321	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
Frame-shift	ENST00000403712	ENST00000367321	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
Frame-shift	ENST00000415006	ENST00000367321	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
In-frame	ENST00000403657	ENST00000367321	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
In-frame	ENST00000405430	ENST00000367321	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
intron-3CDS	ENST00000402632	ENST00000367321	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
intron-intron	ENST00000402632	ENST00000367307	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+
intron-intron	ENST00000402632	ENST00000478643	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000405430

SH3YL1

chr2

229966

ENST00000367321

MTHFD1L

chr6

151243341

3504

1158

1146

3110

654

ENST00000403657

SH3YL1

chr2

229966

ENST00000367321

MTHFD1L

chr6

151243341

5035

2689

2677

4641

654

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000405430	ENST00000367321	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+	0.000941255	0.9990588
ENST00000403657	ENST00000367321	SH3YL1	chr2	229966	-	MTHFD1L	chr6	151243341	+	0.000946455	0.99905354

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Fusion Genomic Features for SH3YL1-MTHFD1L

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SH3YL1	chr2	229965	-	MTHFD1L	chr6	151243340	+	1.04E-08	1
SH3YL1	chr2	229965	-	MTHFD1L	chr6	151243340	+	1.04E-08	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SH3YL1-MTHFD1L

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:229966/chr6:151243341)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MTHFD1L Q6UB35
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. {ECO:0000250, ECO:0000269\|PubMed:16171773}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MTHFD1L

chr2:229966

chr6:151243341

ENST00000367307

34_42

276.0

Compositional bias

Note=Poly-Gly

Tgene

MTHFD1L

chr2:229966

chr6:151243341

ENST00000367307

423_430

276.0

Nucleotide binding

ATP

Tgene

MTHFD1L

chr2:229966

chr6:151243341

ENST00000367321

423_430

328

932.6666666666666

Nucleotide binding

ATP

Tgene

MTHFD1L

chr2:229966

chr6:151243341

ENST00000367307

31_348

276.0

Region

Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase

Tgene

MTHFD1L

chr2:229966

chr6:151243341

ENST00000367307

349_978

276.0

Region

Note=Formyltetrahydrofolate synthetase

Tgene

MTHFD1L

chr2:229966

chr6:151243341

ENST00000367321

349_978

328

932.6666666666666

Region

Note=Formyltetrahydrofolate synthetase

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SH3YL1

chr2:229966

chr6:151243341

ENST00000356150

283_342

260

343.0

Domain

SH3

Hgene

SH3YL1

chr2:229966

chr6:151243341

ENST00000402632

283_342

945.3333333333334

Domain

SH3

Hgene

SH3YL1

chr2:229966

chr6:151243341

ENST00000403657

283_342

164

228.0

Domain

SH3

Hgene

SH3YL1

chr2:229966

chr6:151243341

ENST00000403658

283_342

164

228.0

Domain

SH3

Hgene

SH3YL1

chr2:229966

chr6:151243341

ENST00000403712

283_342

260

324.0

Domain

SH3

Hgene

SH3YL1

chr2:229966

chr6:151243341

ENST00000405430

283_342

260

343.0

Domain

SH3

Hgene

SH3YL1

chr2:229966

chr6:151243341

ENST00000415006

283_342

164

247.0

Domain

SH3

Tgene

MTHFD1L

chr2:229966

chr6:151243341

ENST00000367321

34_42

328

932.6666666666666

Compositional bias

Note=Poly-Gly

Tgene

MTHFD1L

chr2:229966

chr6:151243341

ENST00000367321

31_348

328

932.6666666666666

Region

Note=Methylenetetrahydrofolate dehydrogenase and cyclohydrolase

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Fusion Gene Sequence for SH3YL1-MTHFD1L

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>81539_81539_1_SH3YL1-MTHFD1L_SH3YL1_chr2_229966_ENST00000403657_MTHFD1L_chr6_151243341_ENST00000367321_length(transcript)=5035nt_BP=2689nt
AAGAGGCTTCATTAGTAATGACCTGTGTCTTCATCAGTATGATAGAATGGGACATCAGCACTCTGATCAGGTCATGCTCTATATGCCTTA
TGGTACAGCAGAGGAAAAATGGGTGAGCCATCATTTGATGCTGAGGATGGGATTTGAGGCTTATGTCTAAATTTTTATTTGCATATTCTT
TTTGTTCTGACAGAGAAATTCACTGCATGTAACTATGACCACGCATGATTTTATCAGAAGTTGATTAGAATCTGTAACATTTTCTGTAGT
TCAGCTGACACACTGAAGATGTCCTCACTGTGACCAGCCTTGTCAACAGCTGGATCACAGTGACATAAGCTGTGTCTAGGATGAGTCTTG
CGGTCTGCAGCCGTGTGAGGCTGCATCTGATTCCCAAGTCCAATGGCTCTCTTCCCGTGTTTACAGATCAGGCCATGACCTTTCCCTACA
GCAGGATGTTTGCAAGATTAACTCTCAACTGAGGAATTTGCTTATTTGCTCTAATACTGCTTGGTTGAGAGAGTTCAAAGTAGAAAGTCT
TCTGAGGGGATAAGATTCATGTATTATTTACAGTGCTTCAGTTGCATGTATCAGAAAATCTAGTCTAAATTGCTTTAACAGAAAAAGATG
TTGCTGGTCCATTTGACGAAGAAGTCCAGAGCGGCTTGTGACTTCAGTCTGGCTTTGCAGAGCCCAGGTGCTCTCTCCACCTTCTGCCAG
GTTCCCCTATGAAGGCTTTGCTCTCAGACTCTCCCCTTGTGGAGACAAAAATCCCACAGCAAGTGGAAACAGAAGTGCCTTGGAAAAAGT
TATTCTGGCAGCTCCTATACAAGTCCCCCATCAGATGCTGGTATTGGACCAGCTTTGGTTATAAAGCCCTGCTGTGGCACCAAAAGGAAT
GTCGTCCTGATACAGCAGCCTCGGGTCACCCAATCCACTCCAGATACTATGGCTGCAGCATCAATGTAAGCAGACAAGTTGTGCTGCCTC
TGAAATAAAGTAGATGAAATATTCAGCAGCAGAAAGAACAAGTTTCCACTCCAGTGAACTAATTCAAATGTATCCAGCATCTAGATATAT
GTATAAATGTAATTAAAACATATTGAGCATCTAGAGCATCTCTCCCAAGATAATTACCACCTGATAGTAATGGCTATAAAAGCTAAAAGT
GGAATCAGTCTACATGTTTCGCAATAGGAATCAATTGAAGCATACATCAAAATGCAGACAGTAGTATTGATGGAGTTTCGTTCTTGCTGC
CCAAGCTGGAGTGCAATGGCGCCATCTCGGCTCACTGCAACCTCCACCTTCCAGGTTCAAGTGATTCTCCTGCCTCAGGCTCCTGAGTAG
CTGGGATTACAGGCGCACGTCACCACATCTGGCTAATTTTTTGTATTTTTAGTAGAAATGGGGTTTCACCATGTTAGCCAGGCTGGTCTT
GAACTCCTGACCTCAGGTGATCCCCCCACCTCGGCCTCCCAAATTGCTGGGATTACAGGTGTGAGCCACCGTGTCCGGCCATAAAACATT
TTTTTACAAAAGGCTTACAAAGGAATATTTATAGCAGTTTTATTTGTAATAGCCAAAAGCTGGAAACAACCCAATTGTCTATCAACAGTG
ACTGGAAGGACAAATTGTGCTATGTCCACACATTAGAATACCAGTTGGCAGTCAAAAAGGAAGAGCTGATCTGTGCAGCAATTTGAGTCT
CAGTAATTTCATGTGAATAACCCTATACCTTCCAATTTGAAATCAGAAGCAAAAAAGGCTGCCAAAATATTAAGAGAATTCACAGAAATA
ACTTCCAGAAATGGACCTGATAAGATCATTCCTGCTCACGTAATTGCGAAGGCTAAAGGCCTTGCAATTCTGTCTGTGATCAAAGCCGGG
TTCCTGGTGACTGCCAGAGGAGGCAGCGGGATTGTAGTGGCGCGCCTTCCAGATGGAAAATGGTCTGCACCCTCAGCCATTGGGATAGCT
GGCCTTGGTGGAGGATTTGAAATAGGAATTGAGAGACTGACGAGACACCCATGAATGCTTCCTTTTCTGTAAAATGGGACAATGACAGGA
CCTGTAACCACACAGGGTTTTCCTTTCAAGCACATAGATGGCACACACGTAATCGAGTGCCACTCCAGCTTTCTTAGGTTGCCATCTGCA
TGACACATCTTTCTCCATCCTTTTACTGTCAATCTAATGGTATCAGACTTGGTGATAATTCTGAATTATGACCGTGCTGTAGAAGCTTTT
GCAAAAGGCGGAAATCTGACCCTCGGAGGGAACTTGACTGTGGCGGTTGGGCCCTTGGGAAGGAACTTGGAAGGAAACGTGGCCCTGAGA
AGCTCCGCTGCCGTCTTCACGTACTGCAAGTCAAGGGGACTCTTTGCAGGCGTGTCTTTAGAAGGGAGCTGTTTGATTGAAAGGAAAGAA
ACTAATAGAAAATTTTATTGTCAAGATATCCGAGCTTATGACATTTTATTTGGAGATACACCGCGGCCTGCTCAAGCCGAAGATCTTTAT
GAAATTCTTGATTCCTTTACTGAAAAGTATGAAAATGAAGGACAACGAATCAATGCAAGAAAAGCAGCAAGGGAGCAGAGGAAGTCTTCT
GCTAAAGAATTACCTCCAAAGCCATTGTCAAGACCACAGCAGTCATCTGCACCAGTCCAGCTGAACTCTGGCTCTCAAAAACATGGTCAG
TAGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGTGCCAAGTGA
CATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGAAATCTATGG
CAAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGGGATCACACC
CACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTTTGCCTGCTT
GAGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGAGGAGTTCAA
CCTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCATGAAAACAC
GCAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCGGCTAAAAAA
ACTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATCTACCATCAC
GTGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTACCGGCAGGC
GCAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCTGGGAAGGAT
GGTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAAAGATGCAAT
AAAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAACTCTTCAGT
GTTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAA
ATTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGG
CGGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCA
GAAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTT
GGTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGC
TCGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCAT
TGCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAA
TTTGCCCATCTGCATGGCAAAGACCCACCTTTCTCTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAG
TGACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTT
TTATGACATAGATCTTGATACCGAAACAGAACAAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTG
AAACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAA
TAGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGA
AACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGA

>81539_81539_1_SH3YL1-MTHFD1L_SH3YL1_chr2_229966_ENST00000403657_MTHFD1L_chr6_151243341_ENST00000367321_length(amino acids)=654AA_BP=2
MALKNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISRGQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKY
VLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAID
TRILHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGINKTDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNT
EKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASDKSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFAN
IAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLV
ADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVP
IVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMP

--------------------------------------------------------------
>81539_81539_2_SH3YL1-MTHFD1L_SH3YL1_chr2_229966_ENST00000405430_MTHFD1L_chr6_151243341_ENST00000367321_length(transcript)=3504nt_BP=1158nt
CGAAGGCCTGAGCGCGGCCCGGCGGGCGCGTGGTTTTTGTCCCGCGAAACGTACACGGCGGGTGTTTTGCGCCGCCTCCTTCGTCACCTG
CCGCAGGAAGTGTGGAACTGGTCTCAATCGGTTGACCACCTTAAGGAAATAGGATTTACACTGTGGACAGAGATGTGTCCTTTACACTTC
ATTTGAACCAATATGCCCATGCTCCTGTGGAGGCTGAGTTGGAAAGTGACACGAAGCTGCCCCCCCGCAAGAGAGCAGAAATAAGGATCT
GGCATGTCAACACAAACATAGGAAGTTGAGGCAGTCAAAGGGAAATAACTGCTACCCTGACTCTGCTGAGAGCCTCACAAGTCCCTGTGC
ACGCCAGCTTGTTTGCCATGAATAACCCTATACCTTCCAATTTGAAATCAGAAGCAAAAAAGGCTGCCAAAATATTAAGAGAATTCACAG
AAATAACTTCCAGAAATGGACCTGATAAGATCATTCCTGCTCACGTAATTGCGAAGGCTAAAGGCCTTGCAATTCTGTCTGTGATCAAAG
CCGGGTTCCTGGTGACTGCCAGAGGAGGCAGCGGGATTGTAGTGGCGCGCCTTCCAGATGGAAAATGGTCTGCACCCTCAGCCATTGGGA
TAGCTGGCCTTGGTGGAGGATTTGAAATAGGAATTGAGGTATCAGACTTGGTGATAATTCTGAATTATGACCGTGCTGTAGAAGCTTTTG
CAAAAGGCGGAAATCTGACCCTCGGAGGGAACTTGACTGTGGCGGTTGGGCCCTTGGGAAGGAACTTGGAAGGAAACGTGGCCCTGAGAA
GCTCCGCTGCCGTCTTCACGTACTGCAAGTCAAGGGGACTCTTTGCAGGCGTGTCTTTAGAAGGGAGCTGTTTGATTGAAAGGAAAGAAA
CTAATAGAAAATTTTATTGTCAAGATATCCGAGCTTATGACATTTTATTTGGAGATACACCGCGGCCTGCTCAAGCCGAAGATCTTTATG
AAATTCTTGATTCCTTTACTGAAAAGTATGAAAATGAAGGACAACGAATCAATGCAAGAAAAGCAGCAAGGGAGCAGAGGAAGTCTTCTG
CTAAAGAATTACCTCCAAAGCCATTGTCAAGACCACAGCAGTCATCTGCACCAGTCCAGCTGAACTCTGGCTCTCAAAAACATGGTCAGT
AGTGGAAGGAGATGGCTTCGTGAACAGCAGCACAGGCGGTGGAGACTTCACTGCTTGAAACTTCAGCCTCTCTCCCCTGTGCCAAGTGAC
ATTGAGATTTCAAGAGGACAAACTCCAAAAGCTGTGGATGTCCTTGCCAAGGAGATTGGATTGCTTGCAGATGAAATTGAAATCTATGGC
AAAAGCAAAGCCAAAGTACGTTTGTCCGTGCTAGAAAGGTTAAAGGATCAAGCAGATGGAAAATACGTCTTAGTTGCTGGGATCACACCC
ACCCCTCTTGGAGAAGGGAAGAGCACAGTCACCATCGGGCTTGTGCAGGCTCTGACCGCACACCTGAATGTCAACTCCTTTGCCTGCTTG
AGGCAGCCTTCCCAAGGACCGACGTTTGGAGTGAAAGGAGGAGCCGCGGGTGGTGGATATGCCCAGGTCATCCCCATGGAGGAGTTCAAC
CTTCACTTGACTGGAGACATCCACGCCATCACCGCTGCCAATAACTTGCTGGCTGCCGCCATCGACACGAGGATTCTTCATGAAAACACG
CAAACAGATAAGGCTCTGTATAATCGGCTGGTTCCTTTAGTGAATGGTGTCAGAGAATTTTCAGAAATTCAGCTTGCTCGGCTAAAAAAA
CTGGGAATAAATAAGACTGATCCGAGCACACTGACAGAAGAGGAAGTGAGTAAATTTGCCCGTCTCGACATCGACCCATCTACCATCACG
TGGCAGAGAGTATTGGATACAAATGACCGATTTCTACGAAAAATAACCATCGGGCAGGGAAACACAGAGAAGGGCCATTACCGGCAGGCG
CAGTTTGACATCGCAGTGGCCAGCGAGATCATGGCGGTGCTGGCCCTGACGGACAGCCTCGCAGACATGAAGGCACGGCTGGGAAGGATG
GTGGTGGCCAGTGACAAAAGCGGGCAGCCTGTGACAGCAGATGATTTGGGGGTGACAGGTGCTTTGACAGTTTTGATGAAAGATGCAATA
AAACCAAACCTGATGCAGACCCTGGAAGGGACACCTGTGTTCGTGCATGCGGGCCCTTTTGCTAACATTGCTCACGGCAACTCTTCAGTG
TTGGCTGATAAAATTGCCCTGAAACTGGTTGGTGAAGAAGGATTTGTAGTGACCGAAGCTGGCTTTGGTGCTGACATCGGAATGGAGAAA
TTCTTCAACATCAAGTGCCGAGCTTCCGGCTTGGTGCCCAACGTGGTTGTGTTAGTGGCAACGGTGCGAGCTCTGAAGATGCATGGAGGC
GGGCCAAGTGTAACGGCTGGTGTTCCTCTTAAGAAAGAATATACAGAGGAGAACATCCAGCTGGTGGCAGACGGCTGCTGTAACCTCCAG
AAGCAAATTCAGATCACTCAGCTCTTTGGGGTTCCCGTTGTGGTGGCTCTGAATGTCTTCAAGACCGACACCCGCGCTGAGATTGACTTG
GTGTGTGAGCTTGCAAAGCGGGCTGGTGCCTTTGATGCAGTCCCCTGCTATCACTGGTCCGTTGGTGGAAAAGGATCGGTGGACTTGGCT
CGGGCTGTGAGAGAGGCTGCGAGTAAAAGAAGCCGATTCCAGTTCCTGTATGATGTTCAGGTTCCAATTGTGGACAAGATAAGGACCATT
GCTCAGGCTGTCTATGGAGCCAAAGATATTGAACTCTCTCCTGAGGCACAAGCCAAAATAGATCGTTACACTCAACAGGGTTTTGGAAAT
TTGCCCATCTGCATGGCAAAGACCCACCTTTCTCTATCTCACCAACCTGACAAAAAAGGTGTGCCAAGGGACTTCATCTTACCTATCAGT
GACGTCCGGGCCAGCATAGGCGCTGGGTTCATTTACCCTTTGGTCGGAACGATGAGCACCATGCCAGGACTGCCCACCCGGCCCTGCTTT
TATGACATAGATCTTGATACCGAAACAGAACAAGTTAAAGGCTTGTTCTAAGTGGACAAGGCTCTCACAGGACCCGATGCAGACTCCTGA
AACAGACTACTCTTTGCCTTTTTGCTGCAGTTGGAGAAGAAACTGAATTTGAAAAATGTCTGTTATGCAATGCTGGAGACATGGTGAAAT
AGGCCAAAGATTTCTTCTTCGTTCAAGATGAATTCTGTTCACAGTGGAGTATGGTGTTCGGCAAAAGGACCTCCACCAAGACTGAAAGAA
ACTAATTTATTTCTGTTTCTGTGGAGTTTCCATTATTTCTACTGCTTACACTTTAGAATGTTTATTTTATGGGGACTAAGGGATTAGGAG

>81539_81539_2_SH3YL1-MTHFD1L_SH3YL1_chr2_229966_ENST00000405430_MTHFD1L_chr6_151243341_ENST00000367321_length(amino acids)=654AA_BP=2
MALKNMVSSGRRWLREQQHRRWRLHCLKLQPLSPVPSDIEISRGQTPKAVDVLAKEIGLLADEIEIYGKSKAKVRLSVLERLKDQADGKY
VLVAGITPTPLGEGKSTVTIGLVQALTAHLNVNSFACLRQPSQGPTFGVKGGAAGGGYAQVIPMEEFNLHLTGDIHAITAANNLLAAAID
TRILHENTQTDKALYNRLVPLVNGVREFSEIQLARLKKLGINKTDPSTLTEEEVSKFARLDIDPSTITWQRVLDTNDRFLRKITIGQGNT
EKGHYRQAQFDIAVASEIMAVLALTDSLADMKARLGRMVVASDKSGQPVTADDLGVTGALTVLMKDAIKPNLMQTLEGTPVFVHAGPFAN
IAHGNSSVLADKIALKLVGEEGFVVTEAGFGADIGMEKFFNIKCRASGLVPNVVVLVATVRALKMHGGGPSVTAGVPLKKEYTEENIQLV
ADGCCNLQKQIQITQLFGVPVVVALNVFKTDTRAEIDLVCELAKRAGAFDAVPCYHWSVGGKGSVDLARAVREAASKRSRFQFLYDVQVP
IVDKIRTIAQAVYGAKDIELSPEAQAKIDRYTQQGFGNLPICMAKTHLSLSHQPDKKGVPRDFILPISDVRASIGAGFIYPLVGTMSTMP

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Fusion Gene PPI Analysis for SH3YL1-MTHFD1L

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs for SH3YL1-MTHFD1L

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SH3YL1-MTHFD1L

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source