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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SHANK1-UNC5D (FusionGDB2 ID:81547)

Fusion Gene Summary for SHANK1-UNC5D

check button Fusion gene summary
Fusion gene informationFusion gene name: SHANK1-UNC5D
Fusion gene ID: 81547
HgeneTgene
Gene symbol

SHANK1

UNC5D

Gene ID

50944

137970

Gene nameSH3 and multiple ankyrin repeat domains 1unc-5 netrin receptor D
SynonymsSPANK-1|SSTRIP|synamonPRO34692|Unc5h4
Cytomap

19q13.33

8p12

Type of geneprotein-codingprotein-coding
DescriptionSH3 and multiple ankyrin repeat domains protein 1SSTR-interacting proteinsomatostatin receptor-interacting proteinnetrin receptor UNC5Dnetrin receptor Unc5h4protein unc-5 homolog 4protein unc-5 homolog Dunc-5 homolog 4unc-5 homolog D
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000293441, ENST00000359082, 
ENST00000391814, ENST00000391813, 
ENST00000483981, 		ENST00000449677, 
ENST00000287272, ENST00000404895, 
ENST00000416672, ENST00000420357, 
ENST00000453357, 
Fusion gene scores* DoF score6 X 5 X 3=9017 X 13 X 6=1326
# samples 520
** MAII scorelog2(5/90*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(20/1326*10)=-2.72900887033786
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SHANK1 [Title/Abstract] AND UNC5D [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSHANK1(51214628)-UNC5D(35541065), # samples:1
Anticipated loss of major functional domain due to fusion event.SHANK1-UNC5D seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SHANK1-UNC5D seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUNC5D

GO:0098742

cell-cell adhesion via plasma-membrane adhesion molecules

26235030


check buttonFusion gene breakpoints across SHANK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across UNC5D (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-AC-A2BM-01ASHANK1chr19

51214628

-UNC5Dchr8

35541065

+


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Fusion Gene ORF analysis for SHANK1-UNC5D

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000293441ENST00000449677SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
5CDS-intronENST00000359082ENST00000449677SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
5CDS-intronENST00000391814ENST00000449677SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
Frame-shiftENST00000391814ENST00000287272SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
Frame-shiftENST00000391814ENST00000404895SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
Frame-shiftENST00000391814ENST00000416672SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
Frame-shiftENST00000391814ENST00000420357SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
Frame-shiftENST00000391814ENST00000453357SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
In-frameENST00000293441ENST00000287272SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
In-frameENST00000293441ENST00000404895SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
In-frameENST00000293441ENST00000416672SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
In-frameENST00000293441ENST00000420357SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
In-frameENST00000293441ENST00000453357SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
In-frameENST00000359082ENST00000287272SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
In-frameENST00000359082ENST00000404895SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
In-frameENST00000359082ENST00000416672SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
In-frameENST00000359082ENST00000420357SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
In-frameENST00000359082ENST00000453357SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
intron-3CDSENST00000391813ENST00000287272SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
intron-3CDSENST00000391813ENST00000404895SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
intron-3CDSENST00000391813ENST00000416672SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
intron-3CDSENST00000391813ENST00000420357SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
intron-3CDSENST00000391813ENST00000453357SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
intron-3CDSENST00000483981ENST00000287272SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
intron-3CDSENST00000483981ENST00000404895SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
intron-3CDSENST00000483981ENST00000416672SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
intron-3CDSENST00000483981ENST00000420357SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
intron-3CDSENST00000483981ENST00000453357SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
intron-intronENST00000391813ENST00000449677SHANK1chr19

51214628

-UNC5Dchr8

35541065

+
intron-intronENST00000483981ENST00000449677SHANK1chr19

51214628

-UNC5Dchr8

35541065

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000293441SHANK1chr1951214628-ENST00000287272UNC5Dchr835541065+916810961931801053
ENST00000293441SHANK1chr1951214628-ENST00000453357UNC5Dchr835541065+748710961933871122
ENST00000293441SHANK1chr1951214628-ENST00000404895UNC5Dchr835541065+345010961933871122
ENST00000293441SHANK1chr1951214628-ENST00000420357UNC5Dchr835541065+347210961931861055
ENST00000293441SHANK1chr1951214628-ENST00000416672UNC5Dchr835541065+404810961934021127
ENST00000359082SHANK1chr1951214628-ENST00000287272UNC5Dchr835541065+91491077031611053
ENST00000359082SHANK1chr1951214628-ENST00000453357UNC5Dchr835541065+74681077033681122
ENST00000359082SHANK1chr1951214628-ENST00000404895UNC5Dchr835541065+34311077033681122
ENST00000359082SHANK1chr1951214628-ENST00000420357UNC5Dchr835541065+34531077031671055
ENST00000359082SHANK1chr1951214628-ENST00000416672UNC5Dchr835541065+40291077033831127

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000293441ENST00000287272SHANK1chr1951214628-UNC5Dchr835541065+0.0001272110.9998728
ENST00000293441ENST00000453357SHANK1chr1951214628-UNC5Dchr835541065+0.0002507140.99974924
ENST00000293441ENST00000404895SHANK1chr1951214628-UNC5Dchr835541065+0.001512290.9984877
ENST00000293441ENST00000420357SHANK1chr1951214628-UNC5Dchr835541065+0.0017500520.99824995
ENST00000293441ENST00000416672SHANK1chr1951214628-UNC5Dchr835541065+0.0009130310.999087
ENST00000359082ENST00000287272SHANK1chr1951214628-UNC5Dchr835541065+0.0001250130.99987495
ENST00000359082ENST00000453357SHANK1chr1951214628-UNC5Dchr835541065+0.0002456440.99975437
ENST00000359082ENST00000404895SHANK1chr1951214628-UNC5Dchr835541065+0.0014839790.998516
ENST00000359082ENST00000420357SHANK1chr1951214628-UNC5Dchr835541065+0.0017182680.9982817
ENST00000359082ENST00000416672SHANK1chr1951214628-UNC5Dchr835541065+0.0008932610.9991067

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Fusion Genomic Features for SHANK1-UNC5D


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SHANK1chr1951214627-UNC5Dchr835541064+1.08E-050.9999893
SHANK1chr1951214627-UNC5Dchr835541064+1.08E-050.9999893

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SHANK1-UNC5D


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:51214628/chr8:35541065)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSHANK1chr19:51214628chr8:35541065ENST00000293441-723212_2453592162.0RepeatNote=ANK 1
HgeneSHANK1chr19:51214628chr8:35541065ENST00000293441-723246_2783592162.0RepeatNote=ANK 2
HgeneSHANK1chr19:51214628chr8:35541065ENST00000293441-723279_3123592162.0RepeatNote=ANK 3
HgeneSHANK1chr19:51214628chr8:35541065ENST00000293441-723313_3453592162.0RepeatNote=ANK 4
HgeneSHANK1chr19:51214628chr8:35541065ENST00000359082-722212_2453592153.0RepeatNote=ANK 1
HgeneSHANK1chr19:51214628chr8:35541065ENST00000359082-722246_2783592153.0RepeatNote=ANK 2
HgeneSHANK1chr19:51214628chr8:35541065ENST00000359082-722279_3123592153.0RepeatNote=ANK 3
HgeneSHANK1chr19:51214628chr8:35541065ENST00000359082-722313_3453592153.0RepeatNote=ANK 4
TgeneUNC5Dchr19:51214628chr8:35541065ENST00000404895317252_306190954.0DomainTSP type-1 1
TgeneUNC5Dchr19:51214628chr8:35541065ENST00000404895317308_360190954.0DomainTSP type-1 2
TgeneUNC5Dchr19:51214628chr8:35541065ENST00000404895317542_682190954.0DomainZU5
TgeneUNC5Dchr19:51214628chr8:35541065ENST00000404895317859_936190954.0DomainNote=Death
TgeneUNC5Dchr19:51214628chr8:35541065ENST00000453357317252_306185949.0DomainTSP type-1 1
TgeneUNC5Dchr19:51214628chr8:35541065ENST00000453357317308_360185949.0DomainTSP type-1 2
TgeneUNC5Dchr19:51214628chr8:35541065ENST00000453357317542_682185949.0DomainZU5
TgeneUNC5Dchr19:51214628chr8:35541065ENST00000453357317859_936185949.0DomainNote=Death
TgeneUNC5Dchr19:51214628chr8:35541065ENST00000404895317401_953190954.0Topological domainCytoplasmic
TgeneUNC5Dchr19:51214628chr8:35541065ENST00000453357317401_953185949.0Topological domainCytoplasmic
TgeneUNC5Dchr19:51214628chr8:35541065ENST00000404895317380_400190954.0TransmembraneHelical
TgeneUNC5Dchr19:51214628chr8:35541065ENST00000453357317380_400185949.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSHANK1chr19:51214628chr8:35541065ENST00000293441-7231002_10073592162.0Compositional biasNote=Poly-His
HgeneSHANK1chr19:51214628chr8:35541065ENST00000293441-7231014_10193592162.0Compositional biasNote=Poly-His
HgeneSHANK1chr19:51214628chr8:35541065ENST00000293441-7231189_11953592162.0Compositional biasNote=Poly-Gly
HgeneSHANK1chr19:51214628chr8:35541065ENST00000293441-7231709_17173592162.0Compositional biasNote=Poly-Gly
HgeneSHANK1chr19:51214628chr8:35541065ENST00000293441-7231844_18543592162.0Compositional biasNote=Poly-Pro
HgeneSHANK1chr19:51214628chr8:35541065ENST00000293441-7231896_19023592162.0Compositional biasNote=Poly-Gly
HgeneSHANK1chr19:51214628chr8:35541065ENST00000293441-7231970_19793592162.0Compositional biasNote=Poly-Ser
HgeneSHANK1chr19:51214628chr8:35541065ENST00000359082-7221002_10073592153.0Compositional biasNote=Poly-His
HgeneSHANK1chr19:51214628chr8:35541065ENST00000359082-7221014_10193592153.0Compositional biasNote=Poly-His
HgeneSHANK1chr19:51214628chr8:35541065ENST00000359082-7221189_11953592153.0Compositional biasNote=Poly-Gly
HgeneSHANK1chr19:51214628chr8:35541065ENST00000359082-7221709_17173592153.0Compositional biasNote=Poly-Gly
HgeneSHANK1chr19:51214628chr8:35541065ENST00000359082-7221844_18543592153.0Compositional biasNote=Poly-Pro
HgeneSHANK1chr19:51214628chr8:35541065ENST00000359082-7221896_19023592153.0Compositional biasNote=Poly-Gly
HgeneSHANK1chr19:51214628chr8:35541065ENST00000359082-7221970_19793592153.0Compositional biasNote=Poly-Ser
HgeneSHANK1chr19:51214628chr8:35541065ENST00000391813-191002_100701549.0Compositional biasNote=Poly-His
HgeneSHANK1chr19:51214628chr8:35541065ENST00000391813-191014_101901549.0Compositional biasNote=Poly-His
HgeneSHANK1chr19:51214628chr8:35541065ENST00000391813-191189_119501549.0Compositional biasNote=Poly-Gly
HgeneSHANK1chr19:51214628chr8:35541065ENST00000391813-191709_171701549.0Compositional biasNote=Poly-Gly
HgeneSHANK1chr19:51214628chr8:35541065ENST00000391813-191844_185401549.0Compositional biasNote=Poly-Pro
HgeneSHANK1chr19:51214628chr8:35541065ENST00000391813-191896_190201549.0Compositional biasNote=Poly-Gly
HgeneSHANK1chr19:51214628chr8:35541065ENST00000391813-191970_197901549.0Compositional biasNote=Poly-Ser
HgeneSHANK1chr19:51214628chr8:35541065ENST00000293441-7232098_21613592162.0DomainSAM
HgeneSHANK1chr19:51214628chr8:35541065ENST00000293441-723554_6133592162.0DomainSH3
HgeneSHANK1chr19:51214628chr8:35541065ENST00000293441-723663_7573592162.0DomainPDZ
HgeneSHANK1chr19:51214628chr8:35541065ENST00000359082-7222098_21613592153.0DomainSAM
HgeneSHANK1chr19:51214628chr8:35541065ENST00000359082-722554_6133592153.0DomainSH3
HgeneSHANK1chr19:51214628chr8:35541065ENST00000359082-722663_7573592153.0DomainPDZ
HgeneSHANK1chr19:51214628chr8:35541065ENST00000391813-192098_216101549.0DomainSAM
HgeneSHANK1chr19:51214628chr8:35541065ENST00000391813-19554_61301549.0DomainSH3
HgeneSHANK1chr19:51214628chr8:35541065ENST00000391813-19663_75701549.0DomainPDZ
HgeneSHANK1chr19:51214628chr8:35541065ENST00000293441-723346_3783592162.0RepeatNote=ANK 5
HgeneSHANK1chr19:51214628chr8:35541065ENST00000293441-723379_3953592162.0RepeatNote=ANK 6
HgeneSHANK1chr19:51214628chr8:35541065ENST00000359082-722346_3783592153.0RepeatNote=ANK 5
HgeneSHANK1chr19:51214628chr8:35541065ENST00000359082-722379_3953592153.0RepeatNote=ANK 6
HgeneSHANK1chr19:51214628chr8:35541065ENST00000391813-19212_24501549.0RepeatNote=ANK 1
HgeneSHANK1chr19:51214628chr8:35541065ENST00000391813-19246_27801549.0RepeatNote=ANK 2
HgeneSHANK1chr19:51214628chr8:35541065ENST00000391813-19279_31201549.0RepeatNote=ANK 3
HgeneSHANK1chr19:51214628chr8:35541065ENST00000391813-19313_34501549.0RepeatNote=ANK 4
HgeneSHANK1chr19:51214628chr8:35541065ENST00000391813-19346_37801549.0RepeatNote=ANK 5
HgeneSHANK1chr19:51214628chr8:35541065ENST00000391813-19379_39501549.0RepeatNote=ANK 6
TgeneUNC5Dchr19:51214628chr8:35541065ENST00000404895317153_244190954.0DomainNote=Ig-like C2-type
TgeneUNC5Dchr19:51214628chr8:35541065ENST0000040489531754_151190954.0DomainNote=Ig-like
TgeneUNC5Dchr19:51214628chr8:35541065ENST00000453357317153_244185949.0DomainNote=Ig-like C2-type
TgeneUNC5Dchr19:51214628chr8:35541065ENST0000045335731754_151185949.0DomainNote=Ig-like
TgeneUNC5Dchr19:51214628chr8:35541065ENST0000040489531733_379190954.0Topological domainExtracellular
TgeneUNC5Dchr19:51214628chr8:35541065ENST0000045335731733_379185949.0Topological domainExtracellular


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Fusion Gene Sequence for SHANK1-UNC5D


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81547_81547_1_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000293441_UNC5D_chr8_35541065_ENST00000287272_length(transcript)=9168nt_BP=1096nt
GTCGCCCCGTGGCCCCACAATGACCCACAGCCCCGCGACAAGCGAGGACGAGGAACGCCACAGTGCCAGCGAGTGTCCCGAGGGGGGCTC
AGAGTCCGACAGCTCCCCAGACGGGCCAGGTCGAGGCCCCCGGGGGACCCGGGGCCAGGGCAGTGGGGCACCTGGTAGCCTGGCCTCTGT
TAGAGGCCTCCAGGGCCGCTCAATGTCCGTCCCAGACGACGCCCACTTCAGCATGATGGTCTTCAGGATTGGCATCCCGGACCTGCACCA
GACAAAATGCCTTCGCTTCAACCCCGATGCCACCATCTGGACGGCCAAGCAGCAGGTGCTCTGTGCCCTGAGCGAGAGCCTGCAGGATGT
GCTCAACTATGGCCTGTTCCAACCGGCCACCTCCGGCCGCGATGCCAACTTCCTGGAGGAGGAGAGGCTGCTGCGGGAGTACCCCCAGTC
CTTTGAGAAGGGGGTCCCCTACCTGGAGTTCCGATACAAGACCCGAGTTTACAAACAGACCAACCTGGATGAGAAGCAGCTGGCCAAGTT
GCACACGAAGACGGGGTTGAAGAAGTTCCTGGAGTATGTGCAGCTCGGGACATCTGACAAGGTGGCGCGGCTGCTGGACAAGGGGCTGGA
CCCCAATTACCATGACTCGGATTCGGGAGAGACCCCCTTGACACTGGCGGCCCAGACCGAAGGCTCTGTAGAGGTGATTCGAACCCTGTG
CCTGGGCGGGGCCCACATTGACTTCCGGGCCCGGGATGGCATGACCGCACTGCATAAGGCCGCATGCGCCCGACACTGCCTGGCACTCAC
GGCGCTCCTGGACCTTGGGGGTTCCCCCAACTACAAGGACCGTCGGGGGCTGACCCCTCTGTTCCACACGGCCATGGTGGGTGGTGACCC
CCGATGCTGCGAGCTGCTCCTGTTCAACAGGGCCCAGCTGGGCATAGCTGATGAGAACGGCTGGCAGGAAATCCACCAGGCCTGCCAGCG
GGGTCACTCTCAGCACCTGGAGCATCTGCTTTTCTACGGGGCTGAGCCTGGAGCCCAGAACGCCTCGGGGAACACGGCTCTGCACATCTG
CGCCCTCTACAACAAGGTGGAATGGCTGAAAAATGAAGAGCCCATTGACTCTGAACAAGACGAGAACATTGACACCAGGGCTGACCATAA
CCTGATCATCAGGCAGGCACGGCTCTCGGACTCAGGAAATTACACCTGCATGGCAGCCAACATCGTGGCTAAGAGGAGAAGCCTGTCGGC
CACTGTTGTGGTCTACGTGGATGGGAGCTGGGAAGTGTGGAGCGAATGGTCCGTCTGCAGTCCAGAGTGTGAACATTTGCGGATCCGGGA
GTGCACAGCACCACCCCCGAGAAATGGGGGCAAATTCTGTGAAGGTCTAAGCCAGGAATCTGAAAACTGCACAGATGGTCTTTGCATCCT
AGATAAAAAACCTCTTCATGAAATAAAACCCCAAAGCATTGAGAATGCCAGCGACATTGCTTTGTACTCGGGCTTGGGTGCTGCCGTCGT
GGCCGTTGCAGTCCTGGTCATTGGTGTCACCCTTTACAGACGGAGCCAGAGTGACTATGGCGTGGACGTCATTGACTCTTCTGCATTGAC
AGGTAACTCCCTGCTCCTGAATTCTGCCATGCAGCCAGATCTGACAGTGAGCCGGACATACAGCGGACCCATCTGTCTGCAGGACCCTCT
GGACAAGGAGCTCATGACAGAGTCCTCACTCTTTAACCCTTTGTCGGACATCAAAGTGAAAGTCCAGAGCTCGTTCATGGTTTCCCTGGG
AGTGTCTGAGAGAGCTGAGTACCACGGCAAGAATCATTCCAGGACTTTTCCCCATGGAAACAACCACAGCTTTAGTACAATGCATCCCAG
AAATAAAATGCCCTACATCCAAAATCTGTCATCACTCCCCACAAGGACAGAACTGAGGACAACTGGTGTCTTTGGCCATTTAGGGGGGCG
CTTAGTAATGCCAAATACAGGGGTGAGCTTACTCATACCACACGGTGCCATCCCAGAGGAGAATTCTTGGGAGATTTATATGTCCATCAA
CCAAGGTGAACCCAGCCTCCAGTCAGATGGCTCTGAGGTGCTCCTGAGTCCTGAAGTCACCTGTGGTCCTCCAGACATGATCGTCACCAC
TCCCTTTGCATTGACCATCCCGCACTGTGCAGATGTCAGTTCTGAGCATTGGAATATCCATTTAAAGAAGAGGACACAGCAGGGCAAATG
GGAGGAAGTGATGTCAGTGGAAGATGAATCTACATCCTGTTACTGCCTTTTGGACCCCTTTGCGTGTCATGTGCTCCTGGACAGCTTTGG
GACCTATGCGCTCACTGGAGAGCCAATCACAGACTGTGCCGTGAAGCAACTGAAGGTGGCGGTTTTTGGCTGCATGTCCTGTAACTCCCT
GGATTACAACTTGAGAGTTTACTGTGTGGACAATACCCCTTGTGCATTTCAGGAAGTGGTTTCAGATGAAAGGCATCAAGGTGGACAGCT
CCTGGAAGAACCAAAATTGCTGCATTTCAAAGGGAATACCTTTAGTCTTCAGATTTCTGTCCTTGATATTCCCCCATTCCTCTGGAGAAT
TAAACCATTCACTGCCTGCCAGGAAGTCCCGTTCTCCCGCGTGTGGTGCAGTAACCGGCAGCCCCTGCACTGTGCCTTCTCCCTGGAGCG
TTATACGCCCACTACCACCCAGCTGTCCTGCAAAATCTGCATTCGGCAGCTCAAAGGCCATGAACAGATCCTCCAAGTGCAGACATCAAT
CCTAGAGAGTGAACGAGAAACCATCACTTTCTTCGCACAAGAGGACAGCACTTTCCCTGCACAGACTGGCCCCAAAGCCTTCAAAATTCC
CTACTCCATCAGACAGCGGATTTGTGCTACATTTGATACCCCCAATGCCAAAGGCAAGGACTGGCAGATGTTAGCACAGAAAAACAGCAT
CAACAGGAATTTATCTTATTTCGCTACACAAAGTAGCCCATCTGCTGTCATTTTGAACCTGTGGGAAGCTCGTCATCAGCATGATGGTGA
TCTTGACTCCCTGGCCTGTGCCCTTGAAGAGATTGGGAGGACACACACGAAACTCTCAAACATTTCAGAATCCCAGCTTGATGAAGCCGA
CTTCAACTACAGCAGGCAAAATGGACTCTAGTCCACTTCCTCCCATGAGACAGAGTGATGGCCAGCTTGGGGACATTTGCTTTAAATGGG
AAAGAGGCCGCTTTCTGCCCAGTGGCGTTGGGGGAATTCAGCCTTCATTTATAATCAGTGAGATTCCCCTGTTGAAGAAACTAAATTTTA
TATAGGTAAAACATGTTAATAGGGAAGAGTACAAGCTCTCTTACATATAAGAGGGCTCTACTATCTCCTTGGAATCCACATTTGGGTTAA
CTCCTCAGATTTGGAGTGGCAAGGATAAAAGTGAGGGCAGAAGTAGCTGTGGGAAAAGATGAGCTATGATAATGCTGGGAAGGCAGAGAT
TGATTAAGTGCATGCTTTGAAATAGGTTTTTAATGATGTGCCCCAAAGGGCCAGCTGATTCTGGTACTAGATTGTCAGAGTTTTCTACCA
ACTGGCATCTGTGATGTCAGAGATCATTGTAAAAATGGCTTTTAGACGTGAAACAGGGTTGCCAACCCATTTGTATGACTTCAACAACGT
CAAGGAGGGCATTTAGAATTTAGAATCTGAGCACATCACACCAGCACCAGCTCCCTGTCTCTTCTAGCCACTTAATGGAGACACAATGGA
GAGGTAAGACAGACCACAAACTAGTTCTTATAGTGTACTCCACCTTTTACTTTTTTCCTGAGACAAATCTACCCTTATTCTTTCTTCCTC
TTCCTTACCCCTTGCAGTAGGGAGGTATCAAGGAGCATAATTAAACTTGTCAATACGGAAAGTTGTTTTTTCTAACACAACAAAGTGGGA
CCATCTCTATTCCCATCTAAGCCACTCAAATTGCTGAGTGCTATTAGAACACAGCTTATTACATGGATATGGGGACAGGAGAGATTAAAG
CAGGTTCAAAAACACATGAACTGCAGATGCCATAGGCCTCAAATCAGCTGTAATTCTAGGAGACACGTGTTGATCTAGTTATCTAACATT
GTTGTTATAAGAAAATGAGTTTACTGCATTTTTCAATCCAGATTCTTGAAATTGTCTAACATGTGGGTACTGTGTCATCACAAAATCTCT
CAGTAAGGCTATATGTGATCCTCATTTTGCCTCTTGGGAAATTAGCAGATAGTCTTTGCTCTAAATGATATCTGAGTAAATAGACTTGAG
GAATCCTCTACCACAGTGTCCCTGAAACCACATGCATCATTCAGGAAGCCTTCACCCTGTGACTATTCAGCCTCCCTGAATATGCTTTCT
CTATAGAACCACTAACATATGGCTATTGCTCTATGATTTTTTTTTTTACATTAGGAGGCAGTGATATTGTGGAAGATTGAAATCCACAGA
TAATTCATGACCCTCATCTTATCACTTTACTCCATCTTTTTATCCTATTAAATTATTTTTGACAAGATGTCCTGGTAGACTAAAGGTGAA
CAGATTTGCTCTTGCTCATCTTCTGGTGGATATTTTAACTTGCTATTCACAATCAGGACAACCAAAGTCAAGGACCCAGATGAACCACAA
GGCAGCTAGTCAGCTACTTAGAGGTTGGTTACATTCGAATAAAAAGTAGTCAGGGAATGGGGGAGGTGGGGAGTTGGGGAGTACTTGGCA
GTTGGGATATGATCCATTTTTTTAAACAAGTTTTTTGTAGATCCCTTGTAAAATAATAATAATAATGTTGTGAATCTCCATGCCAAGTGA
AAAAGGCCTAAAGATGAGTTGAATTTGTGATACCATGGGTAAGGCATGGAAGAACTCTTGAATGTGTTGGCCATTTTCTCTAACTAACAT
GTGGTATGTATGGTCCCCTATATTAGATAGAAGTCTTTGCTACATGTAATTCAAAAGCATCTCGCTTTTCTCAGGAACCAAAGGCTTATG
ATGTAGGACAAAGAAATCATCTTAGAACTGTCAAGCATATTTTCACAATACCATGTCAAGATCAGGAAAACACCCTTTTGCTAGTGTGCT
TAACTTATTTATTTCTTCTAGGAAACAATAGATAAACAGCATGAAAATGTAAATCATCTGGCATCACTGATAGAATTTCTGAAAGAGAAA
GAGAAGTAGATGGTCAACCAGTCACTAGTTGGTTGGCATGAGGTGGTGTGCAGAGGAAAGCTGCATTCACTATTGAGTAAAAACTTGTAG
AAAGCACATTATAGAGCTTATGTTGGAATCCATCTTGGAGGATTTTTGTTTTAAACTGTCTTTAGCATTTTCCCTCTTCCCTTCTAATGG
GCATTATAATTGTTTCATCTACTCTGTGAATCTACATAGGTCTTTTTTTTTAGATGTTTGATACATTTTAAGTATTTTTAAATAGATGAA
AATTCTAAATGATTTTCCCTCAAATCTATCTAGATTATTTTAAGATGAGACAAGATTATTGTCAATCCCTGAATGTCTGGAGTTACCTCC
CATGGATTTTTTTTTCCTTTGGCCTGGGTTTTATAAACAACTTGAACATCATATCATATAGGATAACAAAGGAGGAAGTTAACTTAATTC
ACCTCAGACTTCAGCCTAAGATTCAATCAAATTCATCCTTCAGCCTGTCTTGTTTCTTCTTTATGTTTCTTTTACTTATTGCTGCTAGGA
TCCTACATAGGATTTCTATAGAAATGTATGAAATTCTGTGGTCACTGCATGTCAGGATTGCACAGTATGTTACAATACAATTTCAAAGAG
AACCCACATTTGTGAGATTTACAGACCAAGGTGTGGTGGAGGAGGTAGAATTGCAGATCAGATAAAAAGTGAGCTTACACTTGAACTTAG
TTATTCACTGTGACCTAAATTTAGTCCTATTGTAATATGTGCCTGTCACAACACAAATACCCCTCTTGAAAGAGATTTACTCATCTATCC
AAGCACTTAATTTGGAAATTTTATTGTCCTATTGCAAAATGAAACAAAATTAAAAGTGGCCTCGAGTACTTGGTAAGTTACTTAAAATTT
TTACAAAAATATCCCACTCAATGCCAAATCTTTCAGTCCTCAAAGGCATTTAAGTCCAATAGTCATGCTTTAAATATGGCTTTAAATTAT
GCCACCAAAATGGTGCACTTCACAGATTCACCAGACTGTAGCATCATAAAGTTAATTTACAGTTTTTACAACATTGCTTCTACATTCTTA
CTGGTTTACATTAAAATCCTTTAAGCCAAAAGGAAGCTTGCTCTATGGATTTAAATGCAAACTTCATTTACCAGTGCAGGAAGTCTCATA
AAACTCAGATGTACTCCCACAAAAATTTTATTGGCCTTTTTGTAAGAGATGAAAAAGAATTGACACAGTTCTCTTTAAAGAGAAGAACTT
TTTTATTATTATTTTTATCTCCAACTGCAGGTGGTGTCTTTTGCCAAGGTCTCTGTATTTTTCTTTCAGTTGTCTTTGGGAGGGGATGTT
AAGTCAAATCACTAAAACAGGGTTCTCTTTGGATTAAAAGTTCTGGATTTATTGCAACTATTTTCCTTGAGAAACATTCTCAGCATCAGG
ATTGATAAACAAATGTAGATGATTAAAATAGGATAATTGGTTTTAGATAATATCTTCTACTGCCAAACTTCTGGCAAATTTACCTGTGAA
TTTCAAAATGTTATAAAATCTCTTGATATGCTTTTGTTTTTCCTTTTAGCCATTTTCTCTTCAATTTCTTAGTCCCTCTGCCCTCTGTAA
ATGTGTTGAGTGATATAGCTATCAGATGTATTGAAGGCAAAGTTCTCGCAGAGGTCTCTGTTCCAGCTCTGTAAAGGTCACAGGAATCGT
GAAGGAGCTGAGAAATCTTCCTCTCCGGCCCACTGTCTGTGGCCCATTGTCATTGTTTCCTCATGAAACATTGCAGAGTTTGAATCCTCA
GTAACTCTCATTGACTGGATTAGAGGTGATGGCCACAGCAAATGGGAGAGCAAAATGTTGGCCTACAGAGAATGACACAATTTTATTCGC
CTTTGGTGTTAGTTGCCATAGTGCTGTATTTGAAAATCGATGCTTTAGCCAAAAGCTGAATGACCACCGTTTCCGTAGTTTCCACTGTTT
TGTCTGCATAGAATTTTCCTGAACTACAAGCAAAAATGTATTTTGTCCAATGTCACAAAAGTGAAAATGTTACTAATCTTAGATGTGTTG
CATATTTTGTGTTTTTACGTTCCAAACTCTTTCAAAAGCTGCCGTTACAAAGCTGTTTGGCTGTATTGACAGCATGTGGTGTTTTTACAA
AAGCAATTCTAGGAGAGCCAGTGTCTACCATGAACTCCTGACATCCCCACTCCAGGGTCATTCATGACATTGAAATGGCAACTTGTACAC
TGTAATTCTTCGAAAAGTAACAGGGGATGGAAATCAGACCTGGCCGTTAGTCACTAGTGTGTAGTACCGTGATCTGAAGTAGGAAATTTA
ACTGACATAGAATAATTGTGGTTTTTGAAGCAGCTACTCATTGCTTTTTCCTTTTGCTGTGAAGATCATGGATTGGGAATGTCCTCGTGA
GGTGGACCTAAGGCAGTAACATTTAAACTTCATGTCCTAGCACCCGCCCTCCATCTGACCCAAAGATAAAAAAGGCATCAAGCTTCATGG
TTATGCCTAAGCTTAAAAATTCCCTTCCCCACTACTAATATTGAGTTCAGCAGGGCCCCATCTTACTTATTTTTCAAAAAAGTTATAGCT
TTGAATTATAGACTATATTACTAAATTTGGTAAGGTAGTTCTTTGCATGAATGGGAATGTGTGTCAAAATACTTTCACAAAAGGCATGAT
TACAATGGAAATGCCCCTTTGCCTCCAGTTTTGCTAACCCTAAAAAGTATTTCACTAATTTCAAGCACTGTTTACACTCAAATCCCAAAA
TTGGCCAAATTATATAATTCTCTTAAATTTTCATTTCTGTAGGTGGAGATTTAACTATGGTTCTGGTGAATCATAGAAGGGAGAGACAAT
ATTTGAGGGGAGTTTATCAGCAGAATATCATGCCTTATGACCCCATTACTGAAACACAGACATTACAATCAGAAATAGACCTAATAATTC
CAATATCCCTCCATTAACTAGTTCCAGTGATGCTGAGAGACACAGCACCCTGTGCCAGGTATCAGAAATATAAGCCTCAGCAGAGGGTAA
CTGAAAACTTTCAATCAGAAACACTCTCCAAGGCTTATGGCTAGATTATGTAGGTCACTACCATTCAAAACTTTTCTATACAAAGGTGGA
AAAGCACTCAGAATCTGGGAATTTTCTGGTTGGAAGAACAATGTTCTCCTTTTCCAAATTGGAATAAAGACTCAGAATTACCCATTCTTC
ATAATCATGTCTGATTGGTACATACACTCCAGGAAGTCTCAACCTAGAAACATTTCCAACCTAAGCATTTAAAGGAAAACTGGCTCATTC
TTCTGACCCAAACTCAAAAAATATGAGTACTTGCGTACCTCCATTTCTGCATGAAGATTTTAAAACAGATTTCATTTTTTTCTGTTTATT
TTGGGAAGGTGCGTGGGGGTGTTCTTTCAAGTGATTCACATCTCAAACCCATACCACTCTCAACTTTTATTTGATGTGTTCAAAGCCAAA
AAATAAAATAAAATAAAGCAGGGCTGAACACTTAATTTGACATGAAGCTGAAGGACTGAGCAAGCCAGAGGAGAGAGGTTGAATGAAGCA
TAGCCTTGGCTTCATACCACACTTTTTGTGCCTTGTATTATCAATGTAAATTCTGAATGTTGTACAGTAAACTTGGATGGACTTCTTAGA
AAAGGCTGCACTGGCTTCTTTTTCAGCACATGTACATATCTATAAATATATATACATATATATTTGGTAATGCCAAACAGCTCTGTTATA
TTGTATTGAACAAAATGGACGGTTTGGATGTTTTATGTCGAGTTTGCAAAAAAAAAAAAAAAAAAAAAAACTGGATGGTTGCAGACTTTT

>81547_81547_1_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000293441_UNC5D_chr8_35541065_ENST00000287272_length(amino acids)=1053AA_BP=359
MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRF
NPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGL
KKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLG
GSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKV
EWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVDGSWEVWSEWSVCSPECEHLRIRECTAPPP
RNGGKFCEGLSQESENCTDGLCILDKKPLHEIKPQSIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSALTGNSLLL
NSAMQPDLTVSRTYSGPICLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYI
QNLSSLPTRTELRTTGVFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTI
PHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRV
YCVDNTPCAFQEVVSDERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTT
QLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSY

--------------------------------------------------------------
>81547_81547_2_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000293441_UNC5D_chr8_35541065_ENST00000404895_length(transcript)=3450nt_BP=1096nt
GTCGCCCCGTGGCCCCACAATGACCCACAGCCCCGCGACAAGCGAGGACGAGGAACGCCACAGTGCCAGCGAGTGTCCCGAGGGGGGCTC
AGAGTCCGACAGCTCCCCAGACGGGCCAGGTCGAGGCCCCCGGGGGACCCGGGGCCAGGGCAGTGGGGCACCTGGTAGCCTGGCCTCTGT
TAGAGGCCTCCAGGGCCGCTCAATGTCCGTCCCAGACGACGCCCACTTCAGCATGATGGTCTTCAGGATTGGCATCCCGGACCTGCACCA
GACAAAATGCCTTCGCTTCAACCCCGATGCCACCATCTGGACGGCCAAGCAGCAGGTGCTCTGTGCCCTGAGCGAGAGCCTGCAGGATGT
GCTCAACTATGGCCTGTTCCAACCGGCCACCTCCGGCCGCGATGCCAACTTCCTGGAGGAGGAGAGGCTGCTGCGGGAGTACCCCCAGTC
CTTTGAGAAGGGGGTCCCCTACCTGGAGTTCCGATACAAGACCCGAGTTTACAAACAGACCAACCTGGATGAGAAGCAGCTGGCCAAGTT
GCACACGAAGACGGGGTTGAAGAAGTTCCTGGAGTATGTGCAGCTCGGGACATCTGACAAGGTGGCGCGGCTGCTGGACAAGGGGCTGGA
CCCCAATTACCATGACTCGGATTCGGGAGAGACCCCCTTGACACTGGCGGCCCAGACCGAAGGCTCTGTAGAGGTGATTCGAACCCTGTG
CCTGGGCGGGGCCCACATTGACTTCCGGGCCCGGGATGGCATGACCGCACTGCATAAGGCCGCATGCGCCCGACACTGCCTGGCACTCAC
GGCGCTCCTGGACCTTGGGGGTTCCCCCAACTACAAGGACCGTCGGGGGCTGACCCCTCTGTTCCACACGGCCATGGTGGGTGGTGACCC
CCGATGCTGCGAGCTGCTCCTGTTCAACAGGGCCCAGCTGGGCATAGCTGATGAGAACGGCTGGCAGGAAATCCACCAGGCCTGCCAGCG
GGGTCACTCTCAGCACCTGGAGCATCTGCTTTTCTACGGGGCTGAGCCTGGAGCCCAGAACGCCTCGGGGAACACGGCTCTGCACATCTG
CGCCCTCTACAACAAGGTGGAATGGCTGAAAAATGAAGAGCCCATTGACTCTGAACAAGACGAGAACATTGACACCAGGGCTGACCATAA
CCTGATCATCAGGCAGGCACGGCTCTCGGACTCAGGAAATTACACCTGCATGGCAGCCAACATCGTGGCTAAGAGGAGAAGCCTGTCGGC
CACTGTTGTGGTCTACGTGAATGGAGGCTGGTCTTCCTGGACAGAGTGGTCAGCCTGCAATGTTCGCTGTGGTAGAGGATGGCAGAAACG
TTCCCGGACCTGCACCAACCCAGCTCCTCTCAATGGTGGGGCCTTTTGTGAGGGAATGTCAGTGCAGAAAATAACCTGCACTTCTCTTTG
TCCTGTGGATGGGAGCTGGGAAGTGTGGAGCGAATGGTCCGTCTGCAGTCCAGAGTGTGAACATTTGCGGATCCGGGAGTGCACAGCACC
ACCCCCGAGAAATGGGGGCAAATTCTGTGAAGGTCTAAGCCAGGAATCTGAAAACTGCACAGATGGTCTTTGCATCCTAGATAAAAAACC
TCTTCATGAAATAAAACCCCAAAGCATTGAGAATGCCAGCGACATTGCTTTGTACTCGGGCTTGGGTGCTGCCGTCGTGGCCGTTGCAGT
CCTGGTCATTGGTGTCACCCTTTACAGACGGAGCCAGAGTGACTATGGCGTGGACGTCATTGACTCTTCTGCATTGACAGGTGGCTTCCA
GACCTTCAACTTCAAAACAGTCCGTCAAGGTAACTCCCTGCTCCTGAATTCTGCCATGCAGCCAGATCTGACAGTGAGCCGGACATACAG
CGGACCCATCTGTCTGCAGGACCCTCTGGACAAGGAGCTCATGACAGAGTCCTCACTCTTTAACCCTTTGTCGGACATCAAAGTGAAAGT
CCAGAGCTCGTTCATGGTTTCCCTGGGAGTGTCTGAGAGAGCTGAGTACCACGGCAAGAATCATTCCAGGACTTTTCCCCATGGAAACAA
CCACAGCTTTAGTACAATGCATCCCAGAAATAAAATGCCCTACATCCAAAATCTGTCATCACTCCCCACAAGGACAGAACTGAGGACAAC
TGGTGTCTTTGGCCATTTAGGGGGGCGCTTAGTAATGCCAAATACAGGGGTGAGCTTACTCATACCACACGGTGCCATCCCAGAGGAGAA
TTCTTGGGAGATTTATATGTCCATCAACCAAGGTGAACCCAGCCTCCAGTCAGATGGCTCTGAGGTGCTCCTGAGTCCTGAAGTCACCTG
TGGTCCTCCAGACATGATCGTCACCACTCCCTTTGCATTGACCATCCCGCACTGTGCAGATGTCAGTTCTGAGCATTGGAATATCCATTT
AAAGAAGAGGACACAGCAGGGCAAATGGGAGGAAGTGATGTCAGTGGAAGATGAATCTACATCCTGTTACTGCCTTTTGGACCCCTTTGC
GTGTCATGTGCTCCTGGACAGCTTTGGGACCTATGCGCTCACTGGAGAGCCAATCACAGACTGTGCCGTGAAGCAACTGAAGGTGGCGGT
TTTTGGCTGCATGTCCTGTAACTCCCTGGATTACAACTTGAGAGTTTACTGTGTGGACAATACCCCTTGTGCATTTCAGGAAGTGGTTTC
AGATGAAAGGCATCAAGGTGGACAGCTCCTGGAAGAACCAAAATTGCTGCATTTCAAAGGGAATACCTTTAGTCTTCAGATTTCTGTCCT
TGATATTCCCCCATTCCTCTGGAGAATTAAACCATTCACTGCCTGCCAGGAAGTCCCGTTCTCCCGCGTGTGGTGCAGTAACCGGCAGCC
CCTGCACTGTGCCTTCTCCCTGGAGCGTTATACGCCCACTACCACCCAGCTGTCCTGCAAAATCTGCATTCGGCAGCTCAAAGGCCATGA
ACAGATCCTCCAAGTGCAGACATCAATCCTAGAGAGTGAACGAGAAACCATCACTTTCTTCGCACAAGAGGACAGCACTTTCCCTGCACA
GACTGGCCCCAAAGCCTTCAAAATTCCCTACTCCATCAGACAGCGGATTTGTGCTACATTTGATACCCCCAATGCCAAAGGCAAGGACTG
GCAGATGTTAGCACAGAAAAACAGCATCAACAGGAATTTATCTTATTTCGCTACACAAAGTAGCCCATCTGCTGTCATTTTGAACCTGTG
GGAAGCTCGTCATCAGCATGATGGTGATCTTGACTCCCTGGCCTGTGCCCTTGAAGAGATTGGGAGGACACACACGAAACTCTCAAACAT
TTCAGAATCCCAGCTTGATGAAGCCGACTTCAACTACAGCAGGCAAAATGGACTCTAGTCCACTTCCTCCCATGAGACAGAGTGATGGCC

>81547_81547_2_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000293441_UNC5D_chr8_35541065_ENST00000404895_length(amino acids)=1122AA_BP=359
MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRF
NPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGL
KKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLG
GSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKV
EWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTN
PAPLNGGAFCEGMSVQKITCTSLCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKP
QSIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNSAMQPDLTVSRTYSGPICLQ
DPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTGVFGHL
GGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQ
GKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQG
GQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQ
TSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQH

--------------------------------------------------------------
>81547_81547_3_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000293441_UNC5D_chr8_35541065_ENST00000416672_length(transcript)=4048nt_BP=1096nt
GTCGCCCCGTGGCCCCACAATGACCCACAGCCCCGCGACAAGCGAGGACGAGGAACGCCACAGTGCCAGCGAGTGTCCCGAGGGGGGCTC
AGAGTCCGACAGCTCCCCAGACGGGCCAGGTCGAGGCCCCCGGGGGACCCGGGGCCAGGGCAGTGGGGCACCTGGTAGCCTGGCCTCTGT
TAGAGGCCTCCAGGGCCGCTCAATGTCCGTCCCAGACGACGCCCACTTCAGCATGATGGTCTTCAGGATTGGCATCCCGGACCTGCACCA
GACAAAATGCCTTCGCTTCAACCCCGATGCCACCATCTGGACGGCCAAGCAGCAGGTGCTCTGTGCCCTGAGCGAGAGCCTGCAGGATGT
GCTCAACTATGGCCTGTTCCAACCGGCCACCTCCGGCCGCGATGCCAACTTCCTGGAGGAGGAGAGGCTGCTGCGGGAGTACCCCCAGTC
CTTTGAGAAGGGGGTCCCCTACCTGGAGTTCCGATACAAGACCCGAGTTTACAAACAGACCAACCTGGATGAGAAGCAGCTGGCCAAGTT
GCACACGAAGACGGGGTTGAAGAAGTTCCTGGAGTATGTGCAGCTCGGGACATCTGACAAGGTGGCGCGGCTGCTGGACAAGGGGCTGGA
CCCCAATTACCATGACTCGGATTCGGGAGAGACCCCCTTGACACTGGCGGCCCAGACCGAAGGCTCTGTAGAGGTGATTCGAACCCTGTG
CCTGGGCGGGGCCCACATTGACTTCCGGGCCCGGGATGGCATGACCGCACTGCATAAGGCCGCATGCGCCCGACACTGCCTGGCACTCAC
GGCGCTCCTGGACCTTGGGGGTTCCCCCAACTACAAGGACCGTCGGGGGCTGACCCCTCTGTTCCACACGGCCATGGTGGGTGGTGACCC
CCGATGCTGCGAGCTGCTCCTGTTCAACAGGGCCCAGCTGGGCATAGCTGATGAGAACGGCTGGCAGGAAATCCACCAGGCCTGCCAGCG
GGGTCACTCTCAGCACCTGGAGCATCTGCTTTTCTACGGGGCTGAGCCTGGAGCCCAGAACGCCTCGGGGAACACGGCTCTGCACATCTG
CGCCCTCTACAACAAGGTGGAATGGCTGAAAAATGAAGAGCCCATTGACTCTGAACAAGACGAGAACATTGACACCAGGGCTGACCATAA
CCTGATCATCAGGCAGGCACGGCTCTCGGACTCAGGAAATTACACCTGCATGGCAGCCAACATCGTGGCTAAGAGGAGAAGCCTGTCGGC
CACTGTTGTGGTCTACGTGAATGGAGGCTGGTCTTCCTGGACAGAGTGGTCAGCCTGCAATGTTCGCTGTGGTAGAGGATGGCAGAAACG
TTCCCGGACCTGCACCAACCCAGCTCCTCTCAATGGTGGGGCCTTTTGTGAGGGAATGTCAGTGCAGAAAATAACCTGCACTTCTCTTTG
TCCTGTGGATGGGAGCTGGGAAGTGTGGAGCGAATGGTCCGTCTGCAGTCCAGAGTGTGAACATTTGCGGATCCGGGAGTGCACAGCACC
ACCCCCGAGAAATGGGGGCAAATTCTGTGAAGGTCTAAGCCAGGAATCTGAAAACTGCACAGATGGTCTTTGCATCCTAGATAAAAAACC
TCTTCATGAAATAAAACCCCAAAGATGGAGTAGGAGAGGCATTGAGAATGCCAGCGACATTGCTTTGTACTCGGGCTTGGGTGCTGCCGT
CGTGGCCGTTGCAGTCCTGGTCATTGGTGTCACCCTTTACAGACGGAGCCAGAGTGACTATGGCGTGGACGTCATTGACTCTTCTGCATT
GACAGGTGGCTTCCAGACCTTCAACTTCAAAACAGTCCGTCAAGGTAACTCCCTGCTCCTGAATTCTGCCATGCAGCCAGATCTGACAGT
GAGCCGGACATACAGCGGACCCATCTGTCTGCAGGACCCTCTGGACAAGGAGCTCATGACAGAGTCCTCACTCTTTAACCCTTTGTCGGA
CATCAAAGTGAAAGTCCAGAGCTCGTTCATGGTTTCCCTGGGAGTGTCTGAGAGAGCTGAGTACCACGGCAAGAATCATTCCAGGACTTT
TCCCCATGGAAACAACCACAGCTTTAGTACAATGCATCCCAGAAATAAAATGCCCTACATCCAAAATCTGTCATCACTCCCCACAAGGAC
AGAACTGAGGACAACTGGTGTCTTTGGCCATTTAGGGGGGCGCTTAGTAATGCCAAATACAGGGGTGAGCTTACTCATACCACACGGTGC
CATCCCAGAGGAGAATTCTTGGGAGATTTATATGTCCATCAACCAAGGTGAACCCAGCCTCCAGTCAGATGGCTCTGAGGTGCTCCTGAG
TCCTGAAGTCACCTGTGGTCCTCCAGACATGATCGTCACCACTCCCTTTGCATTGACCATCCCGCACTGTGCAGATGTCAGTTCTGAGCA
TTGGAATATCCATTTAAAGAAGAGGACACAGCAGGGCAAATGGGAGGAAGTGATGTCAGTGGAAGATGAATCTACATCCTGTTACTGCCT
TTTGGACCCCTTTGCGTGTCATGTGCTCCTGGACAGCTTTGGGACCTATGCGCTCACTGGAGAGCCAATCACAGACTGTGCCGTGAAGCA
ACTGAAGGTGGCGGTTTTTGGCTGCATGTCCTGTAACTCCCTGGATTACAACTTGAGAGTTTACTGTGTGGACAATACCCCTTGTGCATT
TCAGGAAGTGGTTTCAGATGAAAGGCATCAAGGTGGACAGCTCCTGGAAGAACCAAAATTGCTGCATTTCAAAGGGAATACCTTTAGTCT
TCAGATTTCTGTCCTTGATATTCCCCCATTCCTCTGGAGAATTAAACCATTCACTGCCTGCCAGGAAGTCCCGTTCTCCCGCGTGTGGTG
CAGTAACCGGCAGCCCCTGCACTGTGCCTTCTCCCTGGAGCGTTATACGCCCACTACCACCCAGCTGTCCTGCAAAATCTGCATTCGGCA
GCTCAAAGGCCATGAACAGATCCTCCAAGTGCAGACATCAATCCTAGAGAGTGAACGAGAAACCATCACTTTCTTCGCACAAGAGGACAG
CACTTTCCCTGCACAGACTGGCCCCAAAGCCTTCAAAATTCCCTACTCCATCAGACAGCGGATTTGTGCTACATTTGATACCCCCAATGC
CAAAGGCAAGGACTGGCAGATGTTAGCACAGAAAAACAGCATCAACAGGAATTTATCTTATTTCGCTACACAAAGTAGCCCATCTGCTGT
CATTTTGAACCTGTGGGAAGCTCGTCATCAGCATGATGGTGATCTTGACTCCCTGGCCTGTGCCCTTGAAGAGATTGGGAGGACACACAC
GAAACTCTCAAACATTTCAGAATCCCAGCTTGATGAAGCCGACTTCAACTACAGCAGGCAAAATGGACTCTAGTCCACTTCCTCCCATGA
GACAGAGTGATGGCCAGCTTGGGGACATTTGCTTTAAATGGGAAAGAGGCCGCTTTCTGCCCAGTGGCGTTGGGGGAATTCAGCCTTCAT
TTATAATCAGTGAGATTCCCCTGTTGAAGAAACTAAATTTTATATAGGTAAAACATGTTAATAGGGAAGAGTACAAGCTCTCTTACATAT
AAGAGGGCTCTACTATCTCCTTGGAATCCACATTTGGGTTAACTCCTCAGATTTGGAGTGGCAAGGATAAAAGTGAGGGCAGAAGTAGCT
GTGGGAAAAGATGAGCTATGATAATGCTGGGAAGGCAGAGATTGATTAAGTGCATGCTTTGAAATAGGTTTTTAATGATGTGCCCCAAAG
GGCCAGCTGATTCTGGTACTAGATTGTCAGAGTTTTCTACCAACTGGCATCTGTGATGTCAGAGATCATTGTAAAAATGGCTTTTAGACG
TGAAACAGGGTTGCCAACCCATTTGTATGACTTCAACAACGTCAAGGAGGGCATTTAGAATTTAGAATCTGAGCACATCACACCAGCACC

>81547_81547_3_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000293441_UNC5D_chr8_35541065_ENST00000416672_length(amino acids)=1127AA_BP=359
MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRF
NPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGL
KKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLG
GSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKV
EWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTN
PAPLNGGAFCEGMSVQKITCTSLCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKP
QRWSRRGIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNSAMQPDLTVSRTYSG
PICLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTG
VFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLK
KRTQQGKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSD
ERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQ
ILQVQTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWE

--------------------------------------------------------------
>81547_81547_4_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000293441_UNC5D_chr8_35541065_ENST00000420357_length(transcript)=3472nt_BP=1096nt
GTCGCCCCGTGGCCCCACAATGACCCACAGCCCCGCGACAAGCGAGGACGAGGAACGCCACAGTGCCAGCGAGTGTCCCGAGGGGGGCTC
AGAGTCCGACAGCTCCCCAGACGGGCCAGGTCGAGGCCCCCGGGGGACCCGGGGCCAGGGCAGTGGGGCACCTGGTAGCCTGGCCTCTGT
TAGAGGCCTCCAGGGCCGCTCAATGTCCGTCCCAGACGACGCCCACTTCAGCATGATGGTCTTCAGGATTGGCATCCCGGACCTGCACCA
GACAAAATGCCTTCGCTTCAACCCCGATGCCACCATCTGGACGGCCAAGCAGCAGGTGCTCTGTGCCCTGAGCGAGAGCCTGCAGGATGT
GCTCAACTATGGCCTGTTCCAACCGGCCACCTCCGGCCGCGATGCCAACTTCCTGGAGGAGGAGAGGCTGCTGCGGGAGTACCCCCAGTC
CTTTGAGAAGGGGGTCCCCTACCTGGAGTTCCGATACAAGACCCGAGTTTACAAACAGACCAACCTGGATGAGAAGCAGCTGGCCAAGTT
GCACACGAAGACGGGGTTGAAGAAGTTCCTGGAGTATGTGCAGCTCGGGACATCTGACAAGGTGGCGCGGCTGCTGGACAAGGGGCTGGA
CCCCAATTACCATGACTCGGATTCGGGAGAGACCCCCTTGACACTGGCGGCCCAGACCGAAGGCTCTGTAGAGGTGATTCGAACCCTGTG
CCTGGGCGGGGCCCACATTGACTTCCGGGCCCGGGATGGCATGACCGCACTGCATAAGGCCGCATGCGCCCGACACTGCCTGGCACTCAC
GGCGCTCCTGGACCTTGGGGGTTCCCCCAACTACAAGGACCGTCGGGGGCTGACCCCTCTGTTCCACACGGCCATGGTGGGTGGTGACCC
CCGATGCTGCGAGCTGCTCCTGTTCAACAGGGCCCAGCTGGGCATAGCTGATGAGAACGGCTGGCAGGAAATCCACCAGGCCTGCCAGCG
GGGTCACTCTCAGCACCTGGAGCATCTGCTTTTCTACGGGGCTGAGCCTGGAGCCCAGAACGCCTCGGGGAACACGGCTCTGCACATCTG
CGCCCTCTACAACAAGGTGGAATGGCTGAAAAATGAAGAGCCCATTGACTCTGAACAAGACGAGAACATTGACACCAGGGCTGACCATAA
CCTGATCATCAGGCAGGCACGGCTCTCGGACTCAGGAAATTACACCTGCATGGCAGCCAACATCGTGGCTAAGAGGAGAAGCCTGTCGGC
CACTGTTGTGGTCTACGTGGATGGGAGCTGGGAAGTGTGGAGCGAATGGTCCGTCTGCAGTCCAGAGTGTGAACATTTGCGGATCCGGGA
GTGCACAGCACCACCCCCGAGAAATGGGGGCAAATTCTGTGAAGGTCTAAGCCAGGAATCTGAAAACTGCACAGATGGTCTTTGCATCCT
AGGCATTGAGAATGCCAGCGACATTGCTTTGTACTCGGGCTTGGGTGCTGCCGTCGTGGCCGTTGCAGTCCTGGTCATTGGTGTCACCCT
TTACAGACGGAGCCAGAGTGACTATGGCGTGGACGTCATTGACTCTTCTGCATTGACAGGTGGCTTCCAGACCTTCAACTTCAAAACAGT
CCGTCAAGGTAACTCCCTGCTCCTGAATTCTGCCATGCAGCCAGATCTGACAGTGAGCCGGACATACAGCGGACCCATCTGTCTGCAGGA
CCCTCTGGACAAGGAGCTCATGACAGAGTCCTCACTCTTTAACCCTTTGTCGGACATCAAAGTGAAAGTCCAGAGCTCGTTCATGGTTTC
CCTGGGAGTGTCTGAGAGAGCTGAGTACCACGGCAAGAATCATTCCAGGACTTTTCCCCATGGAAACAACCACAGCTTTAGTACAATGCA
TCCCAGAAATAAAATGCCCTACATCCAAAATCTGTCATCACTCCCCACAAGGACAGAACTGAGGACAACTGGTGTCTTTGGCCATTTAGG
GGGGCGCTTAGTAATGCCAAATACAGGGGTGAGCTTACTCATACCACACGGTGCCATCCCAGAGGAGAATTCTTGGGAGATTTATATGTC
CATCAACCAAGGTGAACCCAGCCTCCAGTCAGATGGCTCTGAGGTGCTCCTGAGTCCTGAAGTCACCTGTGGTCCTCCAGACATGATCGT
CACCACTCCCTTTGCATTGACCATCCCGCACTGTGCAGATGTCAGTTCTGAGCATTGGAATATCCATTTAAAGAAGAGGACACAGCAGGG
CAAATGGGAGGAAGTGATGTCAGTGGAAGATGAATCTACATCCTGTTACTGCCTTTTGGACCCCTTTGCGTGTCATGTGCTCCTGGACAG
CTTTGGGACCTATGCGCTCACTGGAGAGCCAATCACAGACTGTGCCGTGAAGCAACTGAAGGTGGCGGTTTTTGGCTGCATGTCCTGTAA
CTCCCTGGATTACAACTTGAGAGTTTACTGTGTGGACAATACCCCTTGTGCATTTCAGGAAGTGGTTTCAGATGAAAGGCATCAAGGTGG
ACAGCTCCTGGAAGAACCAAAATTGCTGCATTTCAAAGGGAATACCTTTAGTCTTCAGATTTCTGTCCTTGATATTCCCCCATTCCTCTG
GAGAATTAAACCATTCACTGCCTGCCAGGAAGTCCCGTTCTCCCGCGTGTGGTGCAGTAACCGGCAGCCCCTGCACTGTGCCTTCTCCCT
GGAGCGTTATACGCCCACTACCACCCAGCTGTCCTGCAAAATCTGCATTCGGCAGCTCAAAGGCCATGAACAGATCCTCCAAGTGCAGAC
ATCAATCCTAGAGAGTGAACGAGAAACCATCACTTTCTTCGCACAAGAGGACAGCACTTTCCCTGCACAGACTGGCCCCAAAGCCTTCAA
AATTCCCTACTCCATCAGACAGCGGATTTGTGCTACATTTGATACCCCCAATGCCAAAGGCAAGGACTGGCAGATGTTAGCACAGAAAAA
CAGCATCAACAGGAATTTATCTTATTTCGCTACACAAAGTAGCCCATCTGCTGTCATTTTGAACCTGTGGGAAGCTCGTCATCAGCATGA
TGGTGATCTTGACTCCCTGGCCTGTGCCCTTGAAGAGATTGGGAGGACACACACGAAACTCTCAAACATTTCAGAATCCCAGCTTGATGA
AGCCGACTTCAACTACAGCAGGCAAAATGGACTCTAGTCCACTTCCTCCCATGAGACAGAGTGATGGCCAGCTTGGGGACATTTGCTTTA
AATGGGAAAGAGGCCGCTTTCTGCCCAGTGGCGTTGGGGGAATTCAGCCTTCATTTATAATCAGTGAGATTCCCCTGTTGAAGAAACTAA
ATTTTATATAGGTAAAACATGTTAATAGGGAAGAGTACAAGCTCTCTTACATATAAGAGGGCTCTACTATCTCCTTGGAATCCACATTTG

>81547_81547_4_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000293441_UNC5D_chr8_35541065_ENST00000420357_length(amino acids)=1055AA_BP=359
MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRF
NPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGL
KKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLG
GSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKV
EWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVDGSWEVWSEWSVCSPECEHLRIRECTAPPP
RNGGKFCEGLSQESENCTDGLCILGIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSL
LLNSAMQPDLTVSRTYSGPICLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMP
YIQNLSSLPTRTELRTTGVFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFAL
TIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNL
RVYCVDNTPCAFQEVVSDERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPT
TTQLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNL

--------------------------------------------------------------
>81547_81547_5_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000293441_UNC5D_chr8_35541065_ENST00000453357_length(transcript)=7487nt_BP=1096nt
GTCGCCCCGTGGCCCCACAATGACCCACAGCCCCGCGACAAGCGAGGACGAGGAACGCCACAGTGCCAGCGAGTGTCCCGAGGGGGGCTC
AGAGTCCGACAGCTCCCCAGACGGGCCAGGTCGAGGCCCCCGGGGGACCCGGGGCCAGGGCAGTGGGGCACCTGGTAGCCTGGCCTCTGT
TAGAGGCCTCCAGGGCCGCTCAATGTCCGTCCCAGACGACGCCCACTTCAGCATGATGGTCTTCAGGATTGGCATCCCGGACCTGCACCA
GACAAAATGCCTTCGCTTCAACCCCGATGCCACCATCTGGACGGCCAAGCAGCAGGTGCTCTGTGCCCTGAGCGAGAGCCTGCAGGATGT
GCTCAACTATGGCCTGTTCCAACCGGCCACCTCCGGCCGCGATGCCAACTTCCTGGAGGAGGAGAGGCTGCTGCGGGAGTACCCCCAGTC
CTTTGAGAAGGGGGTCCCCTACCTGGAGTTCCGATACAAGACCCGAGTTTACAAACAGACCAACCTGGATGAGAAGCAGCTGGCCAAGTT
GCACACGAAGACGGGGTTGAAGAAGTTCCTGGAGTATGTGCAGCTCGGGACATCTGACAAGGTGGCGCGGCTGCTGGACAAGGGGCTGGA
CCCCAATTACCATGACTCGGATTCGGGAGAGACCCCCTTGACACTGGCGGCCCAGACCGAAGGCTCTGTAGAGGTGATTCGAACCCTGTG
CCTGGGCGGGGCCCACATTGACTTCCGGGCCCGGGATGGCATGACCGCACTGCATAAGGCCGCATGCGCCCGACACTGCCTGGCACTCAC
GGCGCTCCTGGACCTTGGGGGTTCCCCCAACTACAAGGACCGTCGGGGGCTGACCCCTCTGTTCCACACGGCCATGGTGGGTGGTGACCC
CCGATGCTGCGAGCTGCTCCTGTTCAACAGGGCCCAGCTGGGCATAGCTGATGAGAACGGCTGGCAGGAAATCCACCAGGCCTGCCAGCG
GGGTCACTCTCAGCACCTGGAGCATCTGCTTTTCTACGGGGCTGAGCCTGGAGCCCAGAACGCCTCGGGGAACACGGCTCTGCACATCTG
CGCCCTCTACAACAAGGTGGAATGGCTGAAAAATGAAGAGCCCATTGACTCTGAACAAGACGAGAACATTGACACCAGGGCTGACCATAA
CCTGATCATCAGGCAGGCACGGCTCTCGGACTCAGGAAATTACACCTGCATGGCAGCCAACATCGTGGCTAAGAGGAGAAGCCTGTCGGC
CACTGTTGTGGTCTACGTGAATGGAGGCTGGTCTTCCTGGACAGAGTGGTCAGCCTGCAATGTTCGCTGTGGTAGAGGATGGCAGAAACG
TTCCCGGACCTGCACCAACCCAGCTCCTCTCAATGGTGGGGCCTTTTGTGAGGGAATGTCAGTGCAGAAAATAACCTGCACTTCTCTTTG
TCCTGTGGATGGGAGCTGGGAAGTGTGGAGCGAATGGTCCGTCTGCAGTCCAGAGTGTGAACATTTGCGGATCCGGGAGTGCACAGCACC
ACCCCCGAGAAATGGGGGCAAATTCTGTGAAGGTCTAAGCCAGGAATCTGAAAACTGCACAGATGGTCTTTGCATCCTAGATAAAAAACC
TCTTCATGAAATAAAACCCCAAAGCATTGAGAATGCCAGCGACATTGCTTTGTACTCGGGCTTGGGTGCTGCCGTCGTGGCCGTTGCAGT
CCTGGTCATTGGTGTCACCCTTTACAGACGGAGCCAGAGTGACTATGGCGTGGACGTCATTGACTCTTCTGCATTGACAGGTGGCTTCCA
GACCTTCAACTTCAAAACAGTCCGTCAAGGTAACTCCCTGCTCCTGAATTCTGCCATGCAGCCAGATCTGACAGTGAGCCGGACATACAG
CGGACCCATCTGTCTGCAGGACCCTCTGGACAAGGAGCTCATGACAGAGTCCTCACTCTTTAACCCTTTGTCGGACATCAAAGTGAAAGT
CCAGAGCTCGTTCATGGTTTCCCTGGGAGTGTCTGAGAGAGCTGAGTACCACGGCAAGAATCATTCCAGGACTTTTCCCCATGGAAACAA
CCACAGCTTTAGTACAATGCATCCCAGAAATAAAATGCCCTACATCCAAAATCTGTCATCACTCCCCACAAGGACAGAACTGAGGACAAC
TGGTGTCTTTGGCCATTTAGGGGGGCGCTTAGTAATGCCAAATACAGGGGTGAGCTTACTCATACCACACGGTGCCATCCCAGAGGAGAA
TTCTTGGGAGATTTATATGTCCATCAACCAAGGTGAACCCAGCCTCCAGTCAGATGGCTCTGAGGTGCTCCTGAGTCCTGAAGTCACCTG
TGGTCCTCCAGACATGATCGTCACCACTCCCTTTGCATTGACCATCCCGCACTGTGCAGATGTCAGTTCTGAGCATTGGAATATCCATTT
AAAGAAGAGGACACAGCAGGGCAAATGGGAGGAAGTGATGTCAGTGGAAGATGAATCTACATCCTGTTACTGCCTTTTGGACCCCTTTGC
GTGTCATGTGCTCCTGGACAGCTTTGGGACCTATGCGCTCACTGGAGAGCCAATCACAGACTGTGCCGTGAAGCAACTGAAGGTGGCGGT
TTTTGGCTGCATGTCCTGTAACTCCCTGGATTACAACTTGAGAGTTTACTGTGTGGACAATACCCCTTGTGCATTTCAGGAAGTGGTTTC
AGATGAAAGGCATCAAGGTGGACAGCTCCTGGAAGAACCAAAATTGCTGCATTTCAAAGGGAATACCTTTAGTCTTCAGATTTCTGTCCT
TGATATTCCCCCATTCCTCTGGAGAATTAAACCATTCACTGCCTGCCAGGAAGTCCCGTTCTCCCGCGTGTGGTGCAGTAACCGGCAGCC
CCTGCACTGTGCCTTCTCCCTGGAGCGTTATACGCCCACTACCACCCAGCTGTCCTGCAAAATCTGCATTCGGCAGCTCAAAGGCCATGA
ACAGATCCTCCAAGTGCAGACATCAATCCTAGAGAGTGAACGAGAAACCATCACTTTCTTCGCACAAGAGGACAGCACTTTCCCTGCACA
GACTGGCCCCAAAGCCTTCAAAATTCCCTACTCCATCAGACAGCGGATTTGTGCTACATTTGATACCCCCAATGCCAAAGGCAAGGACTG
GCAGATGTTAGCACAGAAAAACAGCATCAACAGGAATTTATCTTATTTCGCTACACAAAGTAGCCCATCTGCTGTCATTTTGAACCTGTG
GGAAGCTCGTCATCAGCATGATGGTGATCTTGACTCCCTGGCCTGTGCCCTTGAAGAGATTGGGAGGACACACACGAAACTCTCAAACAT
TTCAGAATCCCAGCTTGATGAAGCCGACTTCAACTACAGCAGGCAAAATGGACTCTAGTCCACTTCCTCCCATGAGACAGAGTGATGGCC
AGCTTGGGGACATTTGCTTTAAATGGGAAAGAGGCCGCTTTCTGCCCAGTGGCGTTGGGGGAATTCAGCCTTCATTTATAATCAGTGAGA
TTCCCCTGTTGAAGAAACTAAATTTTATATAGGTAAAACATGTTAATAGGGAAGAGTACAAGCTCTCTTACATATAAGAGGGCTCTACTA
TCTCCTTGGAATCCACATTTGGGTTAACTCCTCAGATTTGGAGTGGCAAGGATAAAAGTGAGGGCAGAAGTAGCTGTGGGAAAAGATGAG
CTATGATAATGCTGGGAAGGCAGAGATTGATTAAGTGCATGCTTTGAAATAGGTTTTTAATGATGTGCCCCAAAGGGCCAGCTGATTCTG
GTACTAGATTGTCAGAGTTTTCTACCAACTGGCATCTGTGATGTCAGAGATCATTGTAAAAATGGCTTTTAGACGTGAAACAGGGTTGCC
AACCCATTTGTATGACTTCAACAACGTCAAGGAGGGCATTTAGAATTTAGAATCTGAGCACATCACACCAGCACCAGCTCCCTGTCTCTT
CTAGCCACTTAATGGAGACACAATGGAGAGGTAAGACAGACCACAAACTAGTTCTTATAGTGTACTCCACCTTTTACTTTTTTCCTGAGA
CAAATCTACCCTTATTCTTTCTTCCTCTTCCTTACCCCTTGCAGTAGGGAGGTATCAAGGAGCATAATTAAACTTGTCAATACGGAAAGT
TGTTTTTTCTAACACAACAAAGTGGGACCATCTCTATTCCCATCTAAGCCACTCAAATTGCTGAGTGCTATTAGAACACAGCTTATTACA
TGGATATGGGGACAGGAGAGATTAAAGCAGGTTCAAAAACACATGAACTGCAGATGCCATAGGCCTCAAATCAGCTGTAATTCTAGGAGA
CACGTGTTGATCTAGTTATCTAACATTGTTGTTATAAGAAAATGAGTTTACTGCATTTTTCAATCCAGATTCTTGAAATTGTCTAACATG
TGGGTACTGTGTCATCACAAAATCTCTCAGTAAGGCTATATGTGATCCTCATTTTGCCTCTTGGGAAATTAGCAGATAGTCTTTGCTCTA
AATGATATCTGAGTAAATAGACTTGAGGAATCCTCTACCACAGTGTCCCTGAAACCACATGCATCATTCAGGAAGCCTTCACCCTGTGAC
TATTCAGCCTCCCTGAATATGCTTTCTCTATAGAACCACTAACATATGGCTATTGCTCTATGATTTTTTTTTTTACATTAGGAGGCAGTG
ATATTGTGGAAGATTGAAATCCACAGATAATTCATGACCCTCATCTTATCACTTTACTCCATCTTTTTATCCTATTAAATTATTTTTGAC
AAGATGTCCTGGTAGACTAAAGGTGAACAGATTTGCTCTTGCTCATCTTCTGGTGGATATTTTAACTTGCTATTCACAATCAGGACAACC
AAAGTCAAGGACCCAGATGAACCACAAGGCAGCTAGTCAGCTACTTAGAGGTTGGTTACATTCGAATAAAAAGTAGTCAGGGAATGGGGG
AGGTGGGGAGTTGGGGAGTACTTGGCAGTTGGGATATGATCCATTTTTTTAAACAAGTTTTTTGTAGATCCCTTGTAAAATAATAATAAT
AATGTTGTGAATCTCCATGCCAAGTGAAAAAGGCCTAAAGATGAGTTGAATTTGTGATACCATGGGTAAGGCATGGAAGAACTCTTGAAT
GTGTTGGCCATTTTCTCTAACTAACATGTGGTATGTATGGTCCCCTATATTAGATAGAAGTCTTTGCTACATGTAATTCAAAAGCATCTC
GCTTTTCTCAGGAACCAAAGGCTTATGATGTAGGACAAAGAAATCATCTTAGAACTGTCAAGCATATTTTCACAATACCATGTCAAGATC
AGGAAAACACCCTTTTGCTAGTGTGCTTAACTTATTTATTTCTTCTAGGAAACAATAGATAAACAGCATGAAAATGTAAATCATCTGGCA
TCACTGATAGAATTTCTGAAAGAGAAAGAGAAGTAGATGGTCAACCAGTCACTAGTTGGTTGGCATGAGGTGGTGTGCAGAGGAAAGCTG
CATTCACTATTGAGTAAAAACTTGTAGAAAGCACATTATAGAGCTTATGTTGGAATCCATCTTGGAGGATTTTTGTTTTAAACTGTCTTT
AGCATTTTCCCTCTTCCCTTCTAATGGGCATTATAATTGTTTCATCTACTCTGTGAATCTACATAGGTCTTTTTTTTTAGATGTTTGATA
CATTTTAAGTATTTTTAAATAGATGAAAATTCTAAATGATTTTCCCTCAAATCTATCTAGATTATTTTAAGATGAGACAAGATTATTGTC
AATCCCTGAATGTCTGGAGTTACCTCCCATGGATTTTTTTTTCCTTTGGCCTGGGTTTTATAAACAACTTGAACATCATATCATATAGGA
TAACAAAGGAGGAAGTTAACTTAATTCACCTCAGACTTCAGCCTAAGATTCAATCAAATTCATCCTTCAGCCTGTCTTGTTTCTTCTTTA
TGTTTCTTTTACTTATTGCTGCTAGGATCCTACATAGGATTTCTATAGAAATGTATGAAATTCTGTGGTCACTGCATGTCAGGATTGCAC
AGTATGTTACAATACAATTTCAAAGAGAACCCACATTTGTGAGATTTACAGACCAAGGTGTGGTGGAGGAGGTAGAATTGCAGATCAGAT
AAAAAGTGAGCTTACACTTGAACTTAGTTATTCACTGTGACCTAAATTTAGTCCTATTGTAATATGTGCCTGTCACAACACAAATACCCC
TCTTGAAAGAGATTTACTCATCTATCCAAGCACTTAATTTGGAAATTTTATTGTCCTATTGCAAAATGAAACAAAATTAAAAGTGGCCTC
GAGTACTTGGTAAGTTACTTAAAATTTTTACAAAAATATCCCACTCAATGCCAAATCTTTCAGTCCTCAAAGGCATTTAAGTCCAATAGT
CATGCTTTAAATATGGCTTTAAATTATGCCACCAAAATGGTGCACTTCACAGATTCACCAGACTGTAGCATCATAAAGTTAATTTACAGT
TTTTACAACATTGCTTCTACATTCTTACTGGTTTACATTAAAATCCTTTAAGCCAAAAGGAAGCTTGCTCTATGGATTTAAATGCAAACT
TCATTTACCAGTGCAGGAAGTCTCATAAAACTCAGATGTACTCCCACAAAAATTTTATTGGCCTTTTTGTAAGAGATGAAAAAGAATTGA
CACAGTTCTCTTTAAAGAGAAGAACTTTTTTATTATTATTTTTATCTCCAACTGCAGGTGGTGTCTTTTGCCAAGGTCTCTGTATTTTTC
TTTCAGTTGTCTTTGGGAGGGGATGTTAAGTCAAATCACTAAAACAGGGTTCTCTTTGGATTAAAAGTTCTGGATTTATTGCAACTATTT
TCCTTGAGAAACATTCTCAGCATCAGGATTGATAAACAAATGTAGATGATTAAAATAGGATAATTGGTTTTAGATAATATCTTCTACTGC
CAAACTTCTGGCAAATTTACCTGTGAATTTCAAAATGTTATAAAATCTCTTGATATGCTTTTGTTTTTCCTTTTAGCCATTTTCTCTTCA
ATTTCTTAGTCCCTCTGCCCTCTGTAAATGTGTTGAGTGATATAGCTATCAGATGTATTGAAGGCAAAGTTCTCGCAGAGGTCTCTGTTC
CAGCTCTGTAAAGGTCACAGGAATCGTGAAGGAGCTGAGAAATCTTCCTCTCCGGCCCACTGTCTGTGGCCCATTGTCATTGTTTCCTCA
TGAAACATTGCAGAGTTTGAATCCTCAGTAACTCTCATTGACTGGATTAGAGGTGATGGCCACAGCAAATGGGAGAGCAAAATGTTGGCC
TACAGAGAATGACACAATTTTATTCGCCTTTGGTGTTAGTTGCCATAGTGCTGTATTTGAAAATCGATGCTTTAGCCAAAAGCTGAATGA
CCACCGTTTCCGTAGTTTCCACTGTTTTGTCTGCATAGAATTTTCCTGAACTACAAGCAAAAATGTATTTTGTCCAATGTCACAAAAGTG

>81547_81547_5_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000293441_UNC5D_chr8_35541065_ENST00000453357_length(amino acids)=1122AA_BP=359
MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRF
NPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGL
KKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLG
GSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKV
EWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTN
PAPLNGGAFCEGMSVQKITCTSLCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKP
QSIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNSAMQPDLTVSRTYSGPICLQ
DPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTGVFGHL
GGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQ
GKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQG
GQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQ
TSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQH

--------------------------------------------------------------
>81547_81547_6_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000359082_UNC5D_chr8_35541065_ENST00000287272_length(transcript)=9149nt_BP=1077nt
ATGACCCACAGCCCCGCGACAAGCGAGGACGAGGAACGCCACAGTGCCAGCGAGTGTCCCGAGGGGGGCTCAGAGTCCGACAGCTCCCCA
GACGGGCCAGGTCGAGGCCCCCGGGGGACCCGGGGCCAGGGCAGTGGGGCACCTGGTAGCCTGGCCTCTGTTAGAGGCCTCCAGGGCCGC
TCAATGTCCGTCCCAGACGACGCCCACTTCAGCATGATGGTCTTCAGGATTGGCATCCCGGACCTGCACCAGACAAAATGCCTTCGCTTC
AACCCCGATGCCACCATCTGGACGGCCAAGCAGCAGGTGCTCTGTGCCCTGAGCGAGAGCCTGCAGGATGTGCTCAACTATGGCCTGTTC
CAACCGGCCACCTCCGGCCGCGATGCCAACTTCCTGGAGGAGGAGAGGCTGCTGCGGGAGTACCCCCAGTCCTTTGAGAAGGGGGTCCCC
TACCTGGAGTTCCGATACAAGACCCGAGTTTACAAACAGACCAACCTGGATGAGAAGCAGCTGGCCAAGTTGCACACGAAGACGGGGTTG
AAGAAGTTCCTGGAGTATGTGCAGCTCGGGACATCTGACAAGGTGGCGCGGCTGCTGGACAAGGGGCTGGACCCCAATTACCATGACTCG
GATTCGGGAGAGACCCCCTTGACACTGGCGGCCCAGACCGAAGGCTCTGTAGAGGTGATTCGAACCCTGTGCCTGGGCGGGGCCCACATT
GACTTCCGGGCCCGGGATGGCATGACCGCACTGCATAAGGCCGCATGCGCCCGACACTGCCTGGCACTCACGGCGCTCCTGGACCTTGGG
GGTTCCCCCAACTACAAGGACCGTCGGGGGCTGACCCCTCTGTTCCACACGGCCATGGTGGGTGGTGACCCCCGATGCTGCGAGCTGCTC
CTGTTCAACAGGGCCCAGCTGGGCATAGCTGATGAGAACGGCTGGCAGGAAATCCACCAGGCCTGCCAGCGGGGTCACTCTCAGCACCTG
GAGCATCTGCTTTTCTACGGGGCTGAGCCTGGAGCCCAGAACGCCTCGGGGAACACGGCTCTGCACATCTGCGCCCTCTACAACAAGGTG
GAATGGCTGAAAAATGAAGAGCCCATTGACTCTGAACAAGACGAGAACATTGACACCAGGGCTGACCATAACCTGATCATCAGGCAGGCA
CGGCTCTCGGACTCAGGAAATTACACCTGCATGGCAGCCAACATCGTGGCTAAGAGGAGAAGCCTGTCGGCCACTGTTGTGGTCTACGTG
GATGGGAGCTGGGAAGTGTGGAGCGAATGGTCCGTCTGCAGTCCAGAGTGTGAACATTTGCGGATCCGGGAGTGCACAGCACCACCCCCG
AGAAATGGGGGCAAATTCTGTGAAGGTCTAAGCCAGGAATCTGAAAACTGCACAGATGGTCTTTGCATCCTAGATAAAAAACCTCTTCAT
GAAATAAAACCCCAAAGCATTGAGAATGCCAGCGACATTGCTTTGTACTCGGGCTTGGGTGCTGCCGTCGTGGCCGTTGCAGTCCTGGTC
ATTGGTGTCACCCTTTACAGACGGAGCCAGAGTGACTATGGCGTGGACGTCATTGACTCTTCTGCATTGACAGGTAACTCCCTGCTCCTG
AATTCTGCCATGCAGCCAGATCTGACAGTGAGCCGGACATACAGCGGACCCATCTGTCTGCAGGACCCTCTGGACAAGGAGCTCATGACA
GAGTCCTCACTCTTTAACCCTTTGTCGGACATCAAAGTGAAAGTCCAGAGCTCGTTCATGGTTTCCCTGGGAGTGTCTGAGAGAGCTGAG
TACCACGGCAAGAATCATTCCAGGACTTTTCCCCATGGAAACAACCACAGCTTTAGTACAATGCATCCCAGAAATAAAATGCCCTACATC
CAAAATCTGTCATCACTCCCCACAAGGACAGAACTGAGGACAACTGGTGTCTTTGGCCATTTAGGGGGGCGCTTAGTAATGCCAAATACA
GGGGTGAGCTTACTCATACCACACGGTGCCATCCCAGAGGAGAATTCTTGGGAGATTTATATGTCCATCAACCAAGGTGAACCCAGCCTC
CAGTCAGATGGCTCTGAGGTGCTCCTGAGTCCTGAAGTCACCTGTGGTCCTCCAGACATGATCGTCACCACTCCCTTTGCATTGACCATC
CCGCACTGTGCAGATGTCAGTTCTGAGCATTGGAATATCCATTTAAAGAAGAGGACACAGCAGGGCAAATGGGAGGAAGTGATGTCAGTG
GAAGATGAATCTACATCCTGTTACTGCCTTTTGGACCCCTTTGCGTGTCATGTGCTCCTGGACAGCTTTGGGACCTATGCGCTCACTGGA
GAGCCAATCACAGACTGTGCCGTGAAGCAACTGAAGGTGGCGGTTTTTGGCTGCATGTCCTGTAACTCCCTGGATTACAACTTGAGAGTT
TACTGTGTGGACAATACCCCTTGTGCATTTCAGGAAGTGGTTTCAGATGAAAGGCATCAAGGTGGACAGCTCCTGGAAGAACCAAAATTG
CTGCATTTCAAAGGGAATACCTTTAGTCTTCAGATTTCTGTCCTTGATATTCCCCCATTCCTCTGGAGAATTAAACCATTCACTGCCTGC
CAGGAAGTCCCGTTCTCCCGCGTGTGGTGCAGTAACCGGCAGCCCCTGCACTGTGCCTTCTCCCTGGAGCGTTATACGCCCACTACCACC
CAGCTGTCCTGCAAAATCTGCATTCGGCAGCTCAAAGGCCATGAACAGATCCTCCAAGTGCAGACATCAATCCTAGAGAGTGAACGAGAA
ACCATCACTTTCTTCGCACAAGAGGACAGCACTTTCCCTGCACAGACTGGCCCCAAAGCCTTCAAAATTCCCTACTCCATCAGACAGCGG
ATTTGTGCTACATTTGATACCCCCAATGCCAAAGGCAAGGACTGGCAGATGTTAGCACAGAAAAACAGCATCAACAGGAATTTATCTTAT
TTCGCTACACAAAGTAGCCCATCTGCTGTCATTTTGAACCTGTGGGAAGCTCGTCATCAGCATGATGGTGATCTTGACTCCCTGGCCTGT
GCCCTTGAAGAGATTGGGAGGACACACACGAAACTCTCAAACATTTCAGAATCCCAGCTTGATGAAGCCGACTTCAACTACAGCAGGCAA
AATGGACTCTAGTCCACTTCCTCCCATGAGACAGAGTGATGGCCAGCTTGGGGACATTTGCTTTAAATGGGAAAGAGGCCGCTTTCTGCC
CAGTGGCGTTGGGGGAATTCAGCCTTCATTTATAATCAGTGAGATTCCCCTGTTGAAGAAACTAAATTTTATATAGGTAAAACATGTTAA
TAGGGAAGAGTACAAGCTCTCTTACATATAAGAGGGCTCTACTATCTCCTTGGAATCCACATTTGGGTTAACTCCTCAGATTTGGAGTGG
CAAGGATAAAAGTGAGGGCAGAAGTAGCTGTGGGAAAAGATGAGCTATGATAATGCTGGGAAGGCAGAGATTGATTAAGTGCATGCTTTG
AAATAGGTTTTTAATGATGTGCCCCAAAGGGCCAGCTGATTCTGGTACTAGATTGTCAGAGTTTTCTACCAACTGGCATCTGTGATGTCA
GAGATCATTGTAAAAATGGCTTTTAGACGTGAAACAGGGTTGCCAACCCATTTGTATGACTTCAACAACGTCAAGGAGGGCATTTAGAAT
TTAGAATCTGAGCACATCACACCAGCACCAGCTCCCTGTCTCTTCTAGCCACTTAATGGAGACACAATGGAGAGGTAAGACAGACCACAA
ACTAGTTCTTATAGTGTACTCCACCTTTTACTTTTTTCCTGAGACAAATCTACCCTTATTCTTTCTTCCTCTTCCTTACCCCTTGCAGTA
GGGAGGTATCAAGGAGCATAATTAAACTTGTCAATACGGAAAGTTGTTTTTTCTAACACAACAAAGTGGGACCATCTCTATTCCCATCTA
AGCCACTCAAATTGCTGAGTGCTATTAGAACACAGCTTATTACATGGATATGGGGACAGGAGAGATTAAAGCAGGTTCAAAAACACATGA
ACTGCAGATGCCATAGGCCTCAAATCAGCTGTAATTCTAGGAGACACGTGTTGATCTAGTTATCTAACATTGTTGTTATAAGAAAATGAG
TTTACTGCATTTTTCAATCCAGATTCTTGAAATTGTCTAACATGTGGGTACTGTGTCATCACAAAATCTCTCAGTAAGGCTATATGTGAT
CCTCATTTTGCCTCTTGGGAAATTAGCAGATAGTCTTTGCTCTAAATGATATCTGAGTAAATAGACTTGAGGAATCCTCTACCACAGTGT
CCCTGAAACCACATGCATCATTCAGGAAGCCTTCACCCTGTGACTATTCAGCCTCCCTGAATATGCTTTCTCTATAGAACCACTAACATA
TGGCTATTGCTCTATGATTTTTTTTTTTACATTAGGAGGCAGTGATATTGTGGAAGATTGAAATCCACAGATAATTCATGACCCTCATCT
TATCACTTTACTCCATCTTTTTATCCTATTAAATTATTTTTGACAAGATGTCCTGGTAGACTAAAGGTGAACAGATTTGCTCTTGCTCAT
CTTCTGGTGGATATTTTAACTTGCTATTCACAATCAGGACAACCAAAGTCAAGGACCCAGATGAACCACAAGGCAGCTAGTCAGCTACTT
AGAGGTTGGTTACATTCGAATAAAAAGTAGTCAGGGAATGGGGGAGGTGGGGAGTTGGGGAGTACTTGGCAGTTGGGATATGATCCATTT
TTTTAAACAAGTTTTTTGTAGATCCCTTGTAAAATAATAATAATAATGTTGTGAATCTCCATGCCAAGTGAAAAAGGCCTAAAGATGAGT
TGAATTTGTGATACCATGGGTAAGGCATGGAAGAACTCTTGAATGTGTTGGCCATTTTCTCTAACTAACATGTGGTATGTATGGTCCCCT
ATATTAGATAGAAGTCTTTGCTACATGTAATTCAAAAGCATCTCGCTTTTCTCAGGAACCAAAGGCTTATGATGTAGGACAAAGAAATCA
TCTTAGAACTGTCAAGCATATTTTCACAATACCATGTCAAGATCAGGAAAACACCCTTTTGCTAGTGTGCTTAACTTATTTATTTCTTCT
AGGAAACAATAGATAAACAGCATGAAAATGTAAATCATCTGGCATCACTGATAGAATTTCTGAAAGAGAAAGAGAAGTAGATGGTCAACC
AGTCACTAGTTGGTTGGCATGAGGTGGTGTGCAGAGGAAAGCTGCATTCACTATTGAGTAAAAACTTGTAGAAAGCACATTATAGAGCTT
ATGTTGGAATCCATCTTGGAGGATTTTTGTTTTAAACTGTCTTTAGCATTTTCCCTCTTCCCTTCTAATGGGCATTATAATTGTTTCATC
TACTCTGTGAATCTACATAGGTCTTTTTTTTTAGATGTTTGATACATTTTAAGTATTTTTAAATAGATGAAAATTCTAAATGATTTTCCC
TCAAATCTATCTAGATTATTTTAAGATGAGACAAGATTATTGTCAATCCCTGAATGTCTGGAGTTACCTCCCATGGATTTTTTTTTCCTT
TGGCCTGGGTTTTATAAACAACTTGAACATCATATCATATAGGATAACAAAGGAGGAAGTTAACTTAATTCACCTCAGACTTCAGCCTAA
GATTCAATCAAATTCATCCTTCAGCCTGTCTTGTTTCTTCTTTATGTTTCTTTTACTTATTGCTGCTAGGATCCTACATAGGATTTCTAT
AGAAATGTATGAAATTCTGTGGTCACTGCATGTCAGGATTGCACAGTATGTTACAATACAATTTCAAAGAGAACCCACATTTGTGAGATT
TACAGACCAAGGTGTGGTGGAGGAGGTAGAATTGCAGATCAGATAAAAAGTGAGCTTACACTTGAACTTAGTTATTCACTGTGACCTAAA
TTTAGTCCTATTGTAATATGTGCCTGTCACAACACAAATACCCCTCTTGAAAGAGATTTACTCATCTATCCAAGCACTTAATTTGGAAAT
TTTATTGTCCTATTGCAAAATGAAACAAAATTAAAAGTGGCCTCGAGTACTTGGTAAGTTACTTAAAATTTTTACAAAAATATCCCACTC
AATGCCAAATCTTTCAGTCCTCAAAGGCATTTAAGTCCAATAGTCATGCTTTAAATATGGCTTTAAATTATGCCACCAAAATGGTGCACT
TCACAGATTCACCAGACTGTAGCATCATAAAGTTAATTTACAGTTTTTACAACATTGCTTCTACATTCTTACTGGTTTACATTAAAATCC
TTTAAGCCAAAAGGAAGCTTGCTCTATGGATTTAAATGCAAACTTCATTTACCAGTGCAGGAAGTCTCATAAAACTCAGATGTACTCCCA
CAAAAATTTTATTGGCCTTTTTGTAAGAGATGAAAAAGAATTGACACAGTTCTCTTTAAAGAGAAGAACTTTTTTATTATTATTTTTATC
TCCAACTGCAGGTGGTGTCTTTTGCCAAGGTCTCTGTATTTTTCTTTCAGTTGTCTTTGGGAGGGGATGTTAAGTCAAATCACTAAAACA
GGGTTCTCTTTGGATTAAAAGTTCTGGATTTATTGCAACTATTTTCCTTGAGAAACATTCTCAGCATCAGGATTGATAAACAAATGTAGA
TGATTAAAATAGGATAATTGGTTTTAGATAATATCTTCTACTGCCAAACTTCTGGCAAATTTACCTGTGAATTTCAAAATGTTATAAAAT
CTCTTGATATGCTTTTGTTTTTCCTTTTAGCCATTTTCTCTTCAATTTCTTAGTCCCTCTGCCCTCTGTAAATGTGTTGAGTGATATAGC
TATCAGATGTATTGAAGGCAAAGTTCTCGCAGAGGTCTCTGTTCCAGCTCTGTAAAGGTCACAGGAATCGTGAAGGAGCTGAGAAATCTT
CCTCTCCGGCCCACTGTCTGTGGCCCATTGTCATTGTTTCCTCATGAAACATTGCAGAGTTTGAATCCTCAGTAACTCTCATTGACTGGA
TTAGAGGTGATGGCCACAGCAAATGGGAGAGCAAAATGTTGGCCTACAGAGAATGACACAATTTTATTCGCCTTTGGTGTTAGTTGCCAT
AGTGCTGTATTTGAAAATCGATGCTTTAGCCAAAAGCTGAATGACCACCGTTTCCGTAGTTTCCACTGTTTTGTCTGCATAGAATTTTCC
TGAACTACAAGCAAAAATGTATTTTGTCCAATGTCACAAAAGTGAAAATGTTACTAATCTTAGATGTGTTGCATATTTTGTGTTTTTACG
TTCCAAACTCTTTCAAAAGCTGCCGTTACAAAGCTGTTTGGCTGTATTGACAGCATGTGGTGTTTTTACAAAAGCAATTCTAGGAGAGCC
AGTGTCTACCATGAACTCCTGACATCCCCACTCCAGGGTCATTCATGACATTGAAATGGCAACTTGTACACTGTAATTCTTCGAAAAGTA
ACAGGGGATGGAAATCAGACCTGGCCGTTAGTCACTAGTGTGTAGTACCGTGATCTGAAGTAGGAAATTTAACTGACATAGAATAATTGT
GGTTTTTGAAGCAGCTACTCATTGCTTTTTCCTTTTGCTGTGAAGATCATGGATTGGGAATGTCCTCGTGAGGTGGACCTAAGGCAGTAA
CATTTAAACTTCATGTCCTAGCACCCGCCCTCCATCTGACCCAAAGATAAAAAAGGCATCAAGCTTCATGGTTATGCCTAAGCTTAAAAA
TTCCCTTCCCCACTACTAATATTGAGTTCAGCAGGGCCCCATCTTACTTATTTTTCAAAAAAGTTATAGCTTTGAATTATAGACTATATT
ACTAAATTTGGTAAGGTAGTTCTTTGCATGAATGGGAATGTGTGTCAAAATACTTTCACAAAAGGCATGATTACAATGGAAATGCCCCTT
TGCCTCCAGTTTTGCTAACCCTAAAAAGTATTTCACTAATTTCAAGCACTGTTTACACTCAAATCCCAAAATTGGCCAAATTATATAATT
CTCTTAAATTTTCATTTCTGTAGGTGGAGATTTAACTATGGTTCTGGTGAATCATAGAAGGGAGAGACAATATTTGAGGGGAGTTTATCA
GCAGAATATCATGCCTTATGACCCCATTACTGAAACACAGACATTACAATCAGAAATAGACCTAATAATTCCAATATCCCTCCATTAACT
AGTTCCAGTGATGCTGAGAGACACAGCACCCTGTGCCAGGTATCAGAAATATAAGCCTCAGCAGAGGGTAACTGAAAACTTTCAATCAGA
AACACTCTCCAAGGCTTATGGCTAGATTATGTAGGTCACTACCATTCAAAACTTTTCTATACAAAGGTGGAAAAGCACTCAGAATCTGGG
AATTTTCTGGTTGGAAGAACAATGTTCTCCTTTTCCAAATTGGAATAAAGACTCAGAATTACCCATTCTTCATAATCATGTCTGATTGGT
ACATACACTCCAGGAAGTCTCAACCTAGAAACATTTCCAACCTAAGCATTTAAAGGAAAACTGGCTCATTCTTCTGACCCAAACTCAAAA
AATATGAGTACTTGCGTACCTCCATTTCTGCATGAAGATTTTAAAACAGATTTCATTTTTTTCTGTTTATTTTGGGAAGGTGCGTGGGGG
TGTTCTTTCAAGTGATTCACATCTCAAACCCATACCACTCTCAACTTTTATTTGATGTGTTCAAAGCCAAAAAATAAAATAAAATAAAGC
AGGGCTGAACACTTAATTTGACATGAAGCTGAAGGACTGAGCAAGCCAGAGGAGAGAGGTTGAATGAAGCATAGCCTTGGCTTCATACCA
CACTTTTTGTGCCTTGTATTATCAATGTAAATTCTGAATGTTGTACAGTAAACTTGGATGGACTTCTTAGAAAAGGCTGCACTGGCTTCT
TTTTCAGCACATGTACATATCTATAAATATATATACATATATATTTGGTAATGCCAAACAGCTCTGTTATATTGTATTGAACAAAATGGA
CGGTTTGGATGTTTTATGTCGAGTTTGCAAAAAAAAAAAAAAAAAAAAAAACTGGATGGTTGCAGACTTTTCAAGATAAATGTACAGACG

>81547_81547_6_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000359082_UNC5D_chr8_35541065_ENST00000287272_length(amino acids)=1053AA_BP=359
MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRF
NPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGL
KKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLG
GSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKV
EWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVDGSWEVWSEWSVCSPECEHLRIRECTAPPP
RNGGKFCEGLSQESENCTDGLCILDKKPLHEIKPQSIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSALTGNSLLL
NSAMQPDLTVSRTYSGPICLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYI
QNLSSLPTRTELRTTGVFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTI
PHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRV
YCVDNTPCAFQEVVSDERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTT
QLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSY

--------------------------------------------------------------
>81547_81547_7_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000359082_UNC5D_chr8_35541065_ENST00000404895_length(transcript)=3431nt_BP=1077nt
ATGACCCACAGCCCCGCGACAAGCGAGGACGAGGAACGCCACAGTGCCAGCGAGTGTCCCGAGGGGGGCTCAGAGTCCGACAGCTCCCCA
GACGGGCCAGGTCGAGGCCCCCGGGGGACCCGGGGCCAGGGCAGTGGGGCACCTGGTAGCCTGGCCTCTGTTAGAGGCCTCCAGGGCCGC
TCAATGTCCGTCCCAGACGACGCCCACTTCAGCATGATGGTCTTCAGGATTGGCATCCCGGACCTGCACCAGACAAAATGCCTTCGCTTC
AACCCCGATGCCACCATCTGGACGGCCAAGCAGCAGGTGCTCTGTGCCCTGAGCGAGAGCCTGCAGGATGTGCTCAACTATGGCCTGTTC
CAACCGGCCACCTCCGGCCGCGATGCCAACTTCCTGGAGGAGGAGAGGCTGCTGCGGGAGTACCCCCAGTCCTTTGAGAAGGGGGTCCCC
TACCTGGAGTTCCGATACAAGACCCGAGTTTACAAACAGACCAACCTGGATGAGAAGCAGCTGGCCAAGTTGCACACGAAGACGGGGTTG
AAGAAGTTCCTGGAGTATGTGCAGCTCGGGACATCTGACAAGGTGGCGCGGCTGCTGGACAAGGGGCTGGACCCCAATTACCATGACTCG
GATTCGGGAGAGACCCCCTTGACACTGGCGGCCCAGACCGAAGGCTCTGTAGAGGTGATTCGAACCCTGTGCCTGGGCGGGGCCCACATT
GACTTCCGGGCCCGGGATGGCATGACCGCACTGCATAAGGCCGCATGCGCCCGACACTGCCTGGCACTCACGGCGCTCCTGGACCTTGGG
GGTTCCCCCAACTACAAGGACCGTCGGGGGCTGACCCCTCTGTTCCACACGGCCATGGTGGGTGGTGACCCCCGATGCTGCGAGCTGCTC
CTGTTCAACAGGGCCCAGCTGGGCATAGCTGATGAGAACGGCTGGCAGGAAATCCACCAGGCCTGCCAGCGGGGTCACTCTCAGCACCTG
GAGCATCTGCTTTTCTACGGGGCTGAGCCTGGAGCCCAGAACGCCTCGGGGAACACGGCTCTGCACATCTGCGCCCTCTACAACAAGGTG
GAATGGCTGAAAAATGAAGAGCCCATTGACTCTGAACAAGACGAGAACATTGACACCAGGGCTGACCATAACCTGATCATCAGGCAGGCA
CGGCTCTCGGACTCAGGAAATTACACCTGCATGGCAGCCAACATCGTGGCTAAGAGGAGAAGCCTGTCGGCCACTGTTGTGGTCTACGTG
AATGGAGGCTGGTCTTCCTGGACAGAGTGGTCAGCCTGCAATGTTCGCTGTGGTAGAGGATGGCAGAAACGTTCCCGGACCTGCACCAAC
CCAGCTCCTCTCAATGGTGGGGCCTTTTGTGAGGGAATGTCAGTGCAGAAAATAACCTGCACTTCTCTTTGTCCTGTGGATGGGAGCTGG
GAAGTGTGGAGCGAATGGTCCGTCTGCAGTCCAGAGTGTGAACATTTGCGGATCCGGGAGTGCACAGCACCACCCCCGAGAAATGGGGGC
AAATTCTGTGAAGGTCTAAGCCAGGAATCTGAAAACTGCACAGATGGTCTTTGCATCCTAGATAAAAAACCTCTTCATGAAATAAAACCC
CAAAGCATTGAGAATGCCAGCGACATTGCTTTGTACTCGGGCTTGGGTGCTGCCGTCGTGGCCGTTGCAGTCCTGGTCATTGGTGTCACC
CTTTACAGACGGAGCCAGAGTGACTATGGCGTGGACGTCATTGACTCTTCTGCATTGACAGGTGGCTTCCAGACCTTCAACTTCAAAACA
GTCCGTCAAGGTAACTCCCTGCTCCTGAATTCTGCCATGCAGCCAGATCTGACAGTGAGCCGGACATACAGCGGACCCATCTGTCTGCAG
GACCCTCTGGACAAGGAGCTCATGACAGAGTCCTCACTCTTTAACCCTTTGTCGGACATCAAAGTGAAAGTCCAGAGCTCGTTCATGGTT
TCCCTGGGAGTGTCTGAGAGAGCTGAGTACCACGGCAAGAATCATTCCAGGACTTTTCCCCATGGAAACAACCACAGCTTTAGTACAATG
CATCCCAGAAATAAAATGCCCTACATCCAAAATCTGTCATCACTCCCCACAAGGACAGAACTGAGGACAACTGGTGTCTTTGGCCATTTA
GGGGGGCGCTTAGTAATGCCAAATACAGGGGTGAGCTTACTCATACCACACGGTGCCATCCCAGAGGAGAATTCTTGGGAGATTTATATG
TCCATCAACCAAGGTGAACCCAGCCTCCAGTCAGATGGCTCTGAGGTGCTCCTGAGTCCTGAAGTCACCTGTGGTCCTCCAGACATGATC
GTCACCACTCCCTTTGCATTGACCATCCCGCACTGTGCAGATGTCAGTTCTGAGCATTGGAATATCCATTTAAAGAAGAGGACACAGCAG
GGCAAATGGGAGGAAGTGATGTCAGTGGAAGATGAATCTACATCCTGTTACTGCCTTTTGGACCCCTTTGCGTGTCATGTGCTCCTGGAC
AGCTTTGGGACCTATGCGCTCACTGGAGAGCCAATCACAGACTGTGCCGTGAAGCAACTGAAGGTGGCGGTTTTTGGCTGCATGTCCTGT
AACTCCCTGGATTACAACTTGAGAGTTTACTGTGTGGACAATACCCCTTGTGCATTTCAGGAAGTGGTTTCAGATGAAAGGCATCAAGGT
GGACAGCTCCTGGAAGAACCAAAATTGCTGCATTTCAAAGGGAATACCTTTAGTCTTCAGATTTCTGTCCTTGATATTCCCCCATTCCTC
TGGAGAATTAAACCATTCACTGCCTGCCAGGAAGTCCCGTTCTCCCGCGTGTGGTGCAGTAACCGGCAGCCCCTGCACTGTGCCTTCTCC
CTGGAGCGTTATACGCCCACTACCACCCAGCTGTCCTGCAAAATCTGCATTCGGCAGCTCAAAGGCCATGAACAGATCCTCCAAGTGCAG
ACATCAATCCTAGAGAGTGAACGAGAAACCATCACTTTCTTCGCACAAGAGGACAGCACTTTCCCTGCACAGACTGGCCCCAAAGCCTTC
AAAATTCCCTACTCCATCAGACAGCGGATTTGTGCTACATTTGATACCCCCAATGCCAAAGGCAAGGACTGGCAGATGTTAGCACAGAAA
AACAGCATCAACAGGAATTTATCTTATTTCGCTACACAAAGTAGCCCATCTGCTGTCATTTTGAACCTGTGGGAAGCTCGTCATCAGCAT
GATGGTGATCTTGACTCCCTGGCCTGTGCCCTTGAAGAGATTGGGAGGACACACACGAAACTCTCAAACATTTCAGAATCCCAGCTTGAT
GAAGCCGACTTCAACTACAGCAGGCAAAATGGACTCTAGTCCACTTCCTCCCATGAGACAGAGTGATGGCCAGCTTGGGGACATTTGCTT

>81547_81547_7_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000359082_UNC5D_chr8_35541065_ENST00000404895_length(amino acids)=1122AA_BP=359
MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRF
NPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGL
KKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLG
GSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKV
EWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTN
PAPLNGGAFCEGMSVQKITCTSLCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKP
QSIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNSAMQPDLTVSRTYSGPICLQ
DPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTGVFGHL
GGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQ
GKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQG
GQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQ
TSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQH

--------------------------------------------------------------
>81547_81547_8_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000359082_UNC5D_chr8_35541065_ENST00000416672_length(transcript)=4029nt_BP=1077nt
ATGACCCACAGCCCCGCGACAAGCGAGGACGAGGAACGCCACAGTGCCAGCGAGTGTCCCGAGGGGGGCTCAGAGTCCGACAGCTCCCCA
GACGGGCCAGGTCGAGGCCCCCGGGGGACCCGGGGCCAGGGCAGTGGGGCACCTGGTAGCCTGGCCTCTGTTAGAGGCCTCCAGGGCCGC
TCAATGTCCGTCCCAGACGACGCCCACTTCAGCATGATGGTCTTCAGGATTGGCATCCCGGACCTGCACCAGACAAAATGCCTTCGCTTC
AACCCCGATGCCACCATCTGGACGGCCAAGCAGCAGGTGCTCTGTGCCCTGAGCGAGAGCCTGCAGGATGTGCTCAACTATGGCCTGTTC
CAACCGGCCACCTCCGGCCGCGATGCCAACTTCCTGGAGGAGGAGAGGCTGCTGCGGGAGTACCCCCAGTCCTTTGAGAAGGGGGTCCCC
TACCTGGAGTTCCGATACAAGACCCGAGTTTACAAACAGACCAACCTGGATGAGAAGCAGCTGGCCAAGTTGCACACGAAGACGGGGTTG
AAGAAGTTCCTGGAGTATGTGCAGCTCGGGACATCTGACAAGGTGGCGCGGCTGCTGGACAAGGGGCTGGACCCCAATTACCATGACTCG
GATTCGGGAGAGACCCCCTTGACACTGGCGGCCCAGACCGAAGGCTCTGTAGAGGTGATTCGAACCCTGTGCCTGGGCGGGGCCCACATT
GACTTCCGGGCCCGGGATGGCATGACCGCACTGCATAAGGCCGCATGCGCCCGACACTGCCTGGCACTCACGGCGCTCCTGGACCTTGGG
GGTTCCCCCAACTACAAGGACCGTCGGGGGCTGACCCCTCTGTTCCACACGGCCATGGTGGGTGGTGACCCCCGATGCTGCGAGCTGCTC
CTGTTCAACAGGGCCCAGCTGGGCATAGCTGATGAGAACGGCTGGCAGGAAATCCACCAGGCCTGCCAGCGGGGTCACTCTCAGCACCTG
GAGCATCTGCTTTTCTACGGGGCTGAGCCTGGAGCCCAGAACGCCTCGGGGAACACGGCTCTGCACATCTGCGCCCTCTACAACAAGGTG
GAATGGCTGAAAAATGAAGAGCCCATTGACTCTGAACAAGACGAGAACATTGACACCAGGGCTGACCATAACCTGATCATCAGGCAGGCA
CGGCTCTCGGACTCAGGAAATTACACCTGCATGGCAGCCAACATCGTGGCTAAGAGGAGAAGCCTGTCGGCCACTGTTGTGGTCTACGTG
AATGGAGGCTGGTCTTCCTGGACAGAGTGGTCAGCCTGCAATGTTCGCTGTGGTAGAGGATGGCAGAAACGTTCCCGGACCTGCACCAAC
CCAGCTCCTCTCAATGGTGGGGCCTTTTGTGAGGGAATGTCAGTGCAGAAAATAACCTGCACTTCTCTTTGTCCTGTGGATGGGAGCTGG
GAAGTGTGGAGCGAATGGTCCGTCTGCAGTCCAGAGTGTGAACATTTGCGGATCCGGGAGTGCACAGCACCACCCCCGAGAAATGGGGGC
AAATTCTGTGAAGGTCTAAGCCAGGAATCTGAAAACTGCACAGATGGTCTTTGCATCCTAGATAAAAAACCTCTTCATGAAATAAAACCC
CAAAGATGGAGTAGGAGAGGCATTGAGAATGCCAGCGACATTGCTTTGTACTCGGGCTTGGGTGCTGCCGTCGTGGCCGTTGCAGTCCTG
GTCATTGGTGTCACCCTTTACAGACGGAGCCAGAGTGACTATGGCGTGGACGTCATTGACTCTTCTGCATTGACAGGTGGCTTCCAGACC
TTCAACTTCAAAACAGTCCGTCAAGGTAACTCCCTGCTCCTGAATTCTGCCATGCAGCCAGATCTGACAGTGAGCCGGACATACAGCGGA
CCCATCTGTCTGCAGGACCCTCTGGACAAGGAGCTCATGACAGAGTCCTCACTCTTTAACCCTTTGTCGGACATCAAAGTGAAAGTCCAG
AGCTCGTTCATGGTTTCCCTGGGAGTGTCTGAGAGAGCTGAGTACCACGGCAAGAATCATTCCAGGACTTTTCCCCATGGAAACAACCAC
AGCTTTAGTACAATGCATCCCAGAAATAAAATGCCCTACATCCAAAATCTGTCATCACTCCCCACAAGGACAGAACTGAGGACAACTGGT
GTCTTTGGCCATTTAGGGGGGCGCTTAGTAATGCCAAATACAGGGGTGAGCTTACTCATACCACACGGTGCCATCCCAGAGGAGAATTCT
TGGGAGATTTATATGTCCATCAACCAAGGTGAACCCAGCCTCCAGTCAGATGGCTCTGAGGTGCTCCTGAGTCCTGAAGTCACCTGTGGT
CCTCCAGACATGATCGTCACCACTCCCTTTGCATTGACCATCCCGCACTGTGCAGATGTCAGTTCTGAGCATTGGAATATCCATTTAAAG
AAGAGGACACAGCAGGGCAAATGGGAGGAAGTGATGTCAGTGGAAGATGAATCTACATCCTGTTACTGCCTTTTGGACCCCTTTGCGTGT
CATGTGCTCCTGGACAGCTTTGGGACCTATGCGCTCACTGGAGAGCCAATCACAGACTGTGCCGTGAAGCAACTGAAGGTGGCGGTTTTT
GGCTGCATGTCCTGTAACTCCCTGGATTACAACTTGAGAGTTTACTGTGTGGACAATACCCCTTGTGCATTTCAGGAAGTGGTTTCAGAT
GAAAGGCATCAAGGTGGACAGCTCCTGGAAGAACCAAAATTGCTGCATTTCAAAGGGAATACCTTTAGTCTTCAGATTTCTGTCCTTGAT
ATTCCCCCATTCCTCTGGAGAATTAAACCATTCACTGCCTGCCAGGAAGTCCCGTTCTCCCGCGTGTGGTGCAGTAACCGGCAGCCCCTG
CACTGTGCCTTCTCCCTGGAGCGTTATACGCCCACTACCACCCAGCTGTCCTGCAAAATCTGCATTCGGCAGCTCAAAGGCCATGAACAG
ATCCTCCAAGTGCAGACATCAATCCTAGAGAGTGAACGAGAAACCATCACTTTCTTCGCACAAGAGGACAGCACTTTCCCTGCACAGACT
GGCCCCAAAGCCTTCAAAATTCCCTACTCCATCAGACAGCGGATTTGTGCTACATTTGATACCCCCAATGCCAAAGGCAAGGACTGGCAG
ATGTTAGCACAGAAAAACAGCATCAACAGGAATTTATCTTATTTCGCTACACAAAGTAGCCCATCTGCTGTCATTTTGAACCTGTGGGAA
GCTCGTCATCAGCATGATGGTGATCTTGACTCCCTGGCCTGTGCCCTTGAAGAGATTGGGAGGACACACACGAAACTCTCAAACATTTCA
GAATCCCAGCTTGATGAAGCCGACTTCAACTACAGCAGGCAAAATGGACTCTAGTCCACTTCCTCCCATGAGACAGAGTGATGGCCAGCT
TGGGGACATTTGCTTTAAATGGGAAAGAGGCCGCTTTCTGCCCAGTGGCGTTGGGGGAATTCAGCCTTCATTTATAATCAGTGAGATTCC
CCTGTTGAAGAAACTAAATTTTATATAGGTAAAACATGTTAATAGGGAAGAGTACAAGCTCTCTTACATATAAGAGGGCTCTACTATCTC
CTTGGAATCCACATTTGGGTTAACTCCTCAGATTTGGAGTGGCAAGGATAAAAGTGAGGGCAGAAGTAGCTGTGGGAAAAGATGAGCTAT
GATAATGCTGGGAAGGCAGAGATTGATTAAGTGCATGCTTTGAAATAGGTTTTTAATGATGTGCCCCAAAGGGCCAGCTGATTCTGGTAC
TAGATTGTCAGAGTTTTCTACCAACTGGCATCTGTGATGTCAGAGATCATTGTAAAAATGGCTTTTAGACGTGAAACAGGGTTGCCAACC
CATTTGTATGACTTCAACAACGTCAAGGAGGGCATTTAGAATTTAGAATCTGAGCACATCACACCAGCACCAGCTCCCTGTCTCTTCTAG

>81547_81547_8_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000359082_UNC5D_chr8_35541065_ENST00000416672_length(amino acids)=1127AA_BP=359
MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRF
NPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGL
KKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLG
GSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKV
EWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTN
PAPLNGGAFCEGMSVQKITCTSLCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKP
QRWSRRGIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNSAMQPDLTVSRTYSG
PICLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTG
VFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLK
KRTQQGKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSD
ERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQ
ILQVQTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWE

--------------------------------------------------------------
>81547_81547_9_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000359082_UNC5D_chr8_35541065_ENST00000420357_length(transcript)=3453nt_BP=1077nt
ATGACCCACAGCCCCGCGACAAGCGAGGACGAGGAACGCCACAGTGCCAGCGAGTGTCCCGAGGGGGGCTCAGAGTCCGACAGCTCCCCA
GACGGGCCAGGTCGAGGCCCCCGGGGGACCCGGGGCCAGGGCAGTGGGGCACCTGGTAGCCTGGCCTCTGTTAGAGGCCTCCAGGGCCGC
TCAATGTCCGTCCCAGACGACGCCCACTTCAGCATGATGGTCTTCAGGATTGGCATCCCGGACCTGCACCAGACAAAATGCCTTCGCTTC
AACCCCGATGCCACCATCTGGACGGCCAAGCAGCAGGTGCTCTGTGCCCTGAGCGAGAGCCTGCAGGATGTGCTCAACTATGGCCTGTTC
CAACCGGCCACCTCCGGCCGCGATGCCAACTTCCTGGAGGAGGAGAGGCTGCTGCGGGAGTACCCCCAGTCCTTTGAGAAGGGGGTCCCC
TACCTGGAGTTCCGATACAAGACCCGAGTTTACAAACAGACCAACCTGGATGAGAAGCAGCTGGCCAAGTTGCACACGAAGACGGGGTTG
AAGAAGTTCCTGGAGTATGTGCAGCTCGGGACATCTGACAAGGTGGCGCGGCTGCTGGACAAGGGGCTGGACCCCAATTACCATGACTCG
GATTCGGGAGAGACCCCCTTGACACTGGCGGCCCAGACCGAAGGCTCTGTAGAGGTGATTCGAACCCTGTGCCTGGGCGGGGCCCACATT
GACTTCCGGGCCCGGGATGGCATGACCGCACTGCATAAGGCCGCATGCGCCCGACACTGCCTGGCACTCACGGCGCTCCTGGACCTTGGG
GGTTCCCCCAACTACAAGGACCGTCGGGGGCTGACCCCTCTGTTCCACACGGCCATGGTGGGTGGTGACCCCCGATGCTGCGAGCTGCTC
CTGTTCAACAGGGCCCAGCTGGGCATAGCTGATGAGAACGGCTGGCAGGAAATCCACCAGGCCTGCCAGCGGGGTCACTCTCAGCACCTG
GAGCATCTGCTTTTCTACGGGGCTGAGCCTGGAGCCCAGAACGCCTCGGGGAACACGGCTCTGCACATCTGCGCCCTCTACAACAAGGTG
GAATGGCTGAAAAATGAAGAGCCCATTGACTCTGAACAAGACGAGAACATTGACACCAGGGCTGACCATAACCTGATCATCAGGCAGGCA
CGGCTCTCGGACTCAGGAAATTACACCTGCATGGCAGCCAACATCGTGGCTAAGAGGAGAAGCCTGTCGGCCACTGTTGTGGTCTACGTG
GATGGGAGCTGGGAAGTGTGGAGCGAATGGTCCGTCTGCAGTCCAGAGTGTGAACATTTGCGGATCCGGGAGTGCACAGCACCACCCCCG
AGAAATGGGGGCAAATTCTGTGAAGGTCTAAGCCAGGAATCTGAAAACTGCACAGATGGTCTTTGCATCCTAGGCATTGAGAATGCCAGC
GACATTGCTTTGTACTCGGGCTTGGGTGCTGCCGTCGTGGCCGTTGCAGTCCTGGTCATTGGTGTCACCCTTTACAGACGGAGCCAGAGT
GACTATGGCGTGGACGTCATTGACTCTTCTGCATTGACAGGTGGCTTCCAGACCTTCAACTTCAAAACAGTCCGTCAAGGTAACTCCCTG
CTCCTGAATTCTGCCATGCAGCCAGATCTGACAGTGAGCCGGACATACAGCGGACCCATCTGTCTGCAGGACCCTCTGGACAAGGAGCTC
ATGACAGAGTCCTCACTCTTTAACCCTTTGTCGGACATCAAAGTGAAAGTCCAGAGCTCGTTCATGGTTTCCCTGGGAGTGTCTGAGAGA
GCTGAGTACCACGGCAAGAATCATTCCAGGACTTTTCCCCATGGAAACAACCACAGCTTTAGTACAATGCATCCCAGAAATAAAATGCCC
TACATCCAAAATCTGTCATCACTCCCCACAAGGACAGAACTGAGGACAACTGGTGTCTTTGGCCATTTAGGGGGGCGCTTAGTAATGCCA
AATACAGGGGTGAGCTTACTCATACCACACGGTGCCATCCCAGAGGAGAATTCTTGGGAGATTTATATGTCCATCAACCAAGGTGAACCC
AGCCTCCAGTCAGATGGCTCTGAGGTGCTCCTGAGTCCTGAAGTCACCTGTGGTCCTCCAGACATGATCGTCACCACTCCCTTTGCATTG
ACCATCCCGCACTGTGCAGATGTCAGTTCTGAGCATTGGAATATCCATTTAAAGAAGAGGACACAGCAGGGCAAATGGGAGGAAGTGATG
TCAGTGGAAGATGAATCTACATCCTGTTACTGCCTTTTGGACCCCTTTGCGTGTCATGTGCTCCTGGACAGCTTTGGGACCTATGCGCTC
ACTGGAGAGCCAATCACAGACTGTGCCGTGAAGCAACTGAAGGTGGCGGTTTTTGGCTGCATGTCCTGTAACTCCCTGGATTACAACTTG
AGAGTTTACTGTGTGGACAATACCCCTTGTGCATTTCAGGAAGTGGTTTCAGATGAAAGGCATCAAGGTGGACAGCTCCTGGAAGAACCA
AAATTGCTGCATTTCAAAGGGAATACCTTTAGTCTTCAGATTTCTGTCCTTGATATTCCCCCATTCCTCTGGAGAATTAAACCATTCACT
GCCTGCCAGGAAGTCCCGTTCTCCCGCGTGTGGTGCAGTAACCGGCAGCCCCTGCACTGTGCCTTCTCCCTGGAGCGTTATACGCCCACT
ACCACCCAGCTGTCCTGCAAAATCTGCATTCGGCAGCTCAAAGGCCATGAACAGATCCTCCAAGTGCAGACATCAATCCTAGAGAGTGAA
CGAGAAACCATCACTTTCTTCGCACAAGAGGACAGCACTTTCCCTGCACAGACTGGCCCCAAAGCCTTCAAAATTCCCTACTCCATCAGA
CAGCGGATTTGTGCTACATTTGATACCCCCAATGCCAAAGGCAAGGACTGGCAGATGTTAGCACAGAAAAACAGCATCAACAGGAATTTA
TCTTATTTCGCTACACAAAGTAGCCCATCTGCTGTCATTTTGAACCTGTGGGAAGCTCGTCATCAGCATGATGGTGATCTTGACTCCCTG
GCCTGTGCCCTTGAAGAGATTGGGAGGACACACACGAAACTCTCAAACATTTCAGAATCCCAGCTTGATGAAGCCGACTTCAACTACAGC
AGGCAAAATGGACTCTAGTCCACTTCCTCCCATGAGACAGAGTGATGGCCAGCTTGGGGACATTTGCTTTAAATGGGAAAGAGGCCGCTT
TCTGCCCAGTGGCGTTGGGGGAATTCAGCCTTCATTTATAATCAGTGAGATTCCCCTGTTGAAGAAACTAAATTTTATATAGGTAAAACA
TGTTAATAGGGAAGAGTACAAGCTCTCTTACATATAAGAGGGCTCTACTATCTCCTTGGAATCCACATTTGGGTTAACTCCTCAGATTTG

>81547_81547_9_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000359082_UNC5D_chr8_35541065_ENST00000420357_length(amino acids)=1055AA_BP=359
MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRF
NPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGL
KKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLG
GSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKV
EWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVDGSWEVWSEWSVCSPECEHLRIRECTAPPP
RNGGKFCEGLSQESENCTDGLCILGIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSL
LLNSAMQPDLTVSRTYSGPICLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMP
YIQNLSSLPTRTELRTTGVFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFAL
TIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNL
RVYCVDNTPCAFQEVVSDERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPT
TTQLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNL

--------------------------------------------------------------
>81547_81547_10_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000359082_UNC5D_chr8_35541065_ENST00000453357_length(transcript)=7468nt_BP=1077nt
ATGACCCACAGCCCCGCGACAAGCGAGGACGAGGAACGCCACAGTGCCAGCGAGTGTCCCGAGGGGGGCTCAGAGTCCGACAGCTCCCCA
GACGGGCCAGGTCGAGGCCCCCGGGGGACCCGGGGCCAGGGCAGTGGGGCACCTGGTAGCCTGGCCTCTGTTAGAGGCCTCCAGGGCCGC
TCAATGTCCGTCCCAGACGACGCCCACTTCAGCATGATGGTCTTCAGGATTGGCATCCCGGACCTGCACCAGACAAAATGCCTTCGCTTC
AACCCCGATGCCACCATCTGGACGGCCAAGCAGCAGGTGCTCTGTGCCCTGAGCGAGAGCCTGCAGGATGTGCTCAACTATGGCCTGTTC
CAACCGGCCACCTCCGGCCGCGATGCCAACTTCCTGGAGGAGGAGAGGCTGCTGCGGGAGTACCCCCAGTCCTTTGAGAAGGGGGTCCCC
TACCTGGAGTTCCGATACAAGACCCGAGTTTACAAACAGACCAACCTGGATGAGAAGCAGCTGGCCAAGTTGCACACGAAGACGGGGTTG
AAGAAGTTCCTGGAGTATGTGCAGCTCGGGACATCTGACAAGGTGGCGCGGCTGCTGGACAAGGGGCTGGACCCCAATTACCATGACTCG
GATTCGGGAGAGACCCCCTTGACACTGGCGGCCCAGACCGAAGGCTCTGTAGAGGTGATTCGAACCCTGTGCCTGGGCGGGGCCCACATT
GACTTCCGGGCCCGGGATGGCATGACCGCACTGCATAAGGCCGCATGCGCCCGACACTGCCTGGCACTCACGGCGCTCCTGGACCTTGGG
GGTTCCCCCAACTACAAGGACCGTCGGGGGCTGACCCCTCTGTTCCACACGGCCATGGTGGGTGGTGACCCCCGATGCTGCGAGCTGCTC
CTGTTCAACAGGGCCCAGCTGGGCATAGCTGATGAGAACGGCTGGCAGGAAATCCACCAGGCCTGCCAGCGGGGTCACTCTCAGCACCTG
GAGCATCTGCTTTTCTACGGGGCTGAGCCTGGAGCCCAGAACGCCTCGGGGAACACGGCTCTGCACATCTGCGCCCTCTACAACAAGGTG
GAATGGCTGAAAAATGAAGAGCCCATTGACTCTGAACAAGACGAGAACATTGACACCAGGGCTGACCATAACCTGATCATCAGGCAGGCA
CGGCTCTCGGACTCAGGAAATTACACCTGCATGGCAGCCAACATCGTGGCTAAGAGGAGAAGCCTGTCGGCCACTGTTGTGGTCTACGTG
AATGGAGGCTGGTCTTCCTGGACAGAGTGGTCAGCCTGCAATGTTCGCTGTGGTAGAGGATGGCAGAAACGTTCCCGGACCTGCACCAAC
CCAGCTCCTCTCAATGGTGGGGCCTTTTGTGAGGGAATGTCAGTGCAGAAAATAACCTGCACTTCTCTTTGTCCTGTGGATGGGAGCTGG
GAAGTGTGGAGCGAATGGTCCGTCTGCAGTCCAGAGTGTGAACATTTGCGGATCCGGGAGTGCACAGCACCACCCCCGAGAAATGGGGGC
AAATTCTGTGAAGGTCTAAGCCAGGAATCTGAAAACTGCACAGATGGTCTTTGCATCCTAGATAAAAAACCTCTTCATGAAATAAAACCC
CAAAGCATTGAGAATGCCAGCGACATTGCTTTGTACTCGGGCTTGGGTGCTGCCGTCGTGGCCGTTGCAGTCCTGGTCATTGGTGTCACC
CTTTACAGACGGAGCCAGAGTGACTATGGCGTGGACGTCATTGACTCTTCTGCATTGACAGGTGGCTTCCAGACCTTCAACTTCAAAACA
GTCCGTCAAGGTAACTCCCTGCTCCTGAATTCTGCCATGCAGCCAGATCTGACAGTGAGCCGGACATACAGCGGACCCATCTGTCTGCAG
GACCCTCTGGACAAGGAGCTCATGACAGAGTCCTCACTCTTTAACCCTTTGTCGGACATCAAAGTGAAAGTCCAGAGCTCGTTCATGGTT
TCCCTGGGAGTGTCTGAGAGAGCTGAGTACCACGGCAAGAATCATTCCAGGACTTTTCCCCATGGAAACAACCACAGCTTTAGTACAATG
CATCCCAGAAATAAAATGCCCTACATCCAAAATCTGTCATCACTCCCCACAAGGACAGAACTGAGGACAACTGGTGTCTTTGGCCATTTA
GGGGGGCGCTTAGTAATGCCAAATACAGGGGTGAGCTTACTCATACCACACGGTGCCATCCCAGAGGAGAATTCTTGGGAGATTTATATG
TCCATCAACCAAGGTGAACCCAGCCTCCAGTCAGATGGCTCTGAGGTGCTCCTGAGTCCTGAAGTCACCTGTGGTCCTCCAGACATGATC
GTCACCACTCCCTTTGCATTGACCATCCCGCACTGTGCAGATGTCAGTTCTGAGCATTGGAATATCCATTTAAAGAAGAGGACACAGCAG
GGCAAATGGGAGGAAGTGATGTCAGTGGAAGATGAATCTACATCCTGTTACTGCCTTTTGGACCCCTTTGCGTGTCATGTGCTCCTGGAC
AGCTTTGGGACCTATGCGCTCACTGGAGAGCCAATCACAGACTGTGCCGTGAAGCAACTGAAGGTGGCGGTTTTTGGCTGCATGTCCTGT
AACTCCCTGGATTACAACTTGAGAGTTTACTGTGTGGACAATACCCCTTGTGCATTTCAGGAAGTGGTTTCAGATGAAAGGCATCAAGGT
GGACAGCTCCTGGAAGAACCAAAATTGCTGCATTTCAAAGGGAATACCTTTAGTCTTCAGATTTCTGTCCTTGATATTCCCCCATTCCTC
TGGAGAATTAAACCATTCACTGCCTGCCAGGAAGTCCCGTTCTCCCGCGTGTGGTGCAGTAACCGGCAGCCCCTGCACTGTGCCTTCTCC
CTGGAGCGTTATACGCCCACTACCACCCAGCTGTCCTGCAAAATCTGCATTCGGCAGCTCAAAGGCCATGAACAGATCCTCCAAGTGCAG
ACATCAATCCTAGAGAGTGAACGAGAAACCATCACTTTCTTCGCACAAGAGGACAGCACTTTCCCTGCACAGACTGGCCCCAAAGCCTTC
AAAATTCCCTACTCCATCAGACAGCGGATTTGTGCTACATTTGATACCCCCAATGCCAAAGGCAAGGACTGGCAGATGTTAGCACAGAAA
AACAGCATCAACAGGAATTTATCTTATTTCGCTACACAAAGTAGCCCATCTGCTGTCATTTTGAACCTGTGGGAAGCTCGTCATCAGCAT
GATGGTGATCTTGACTCCCTGGCCTGTGCCCTTGAAGAGATTGGGAGGACACACACGAAACTCTCAAACATTTCAGAATCCCAGCTTGAT
GAAGCCGACTTCAACTACAGCAGGCAAAATGGACTCTAGTCCACTTCCTCCCATGAGACAGAGTGATGGCCAGCTTGGGGACATTTGCTT
TAAATGGGAAAGAGGCCGCTTTCTGCCCAGTGGCGTTGGGGGAATTCAGCCTTCATTTATAATCAGTGAGATTCCCCTGTTGAAGAAACT
AAATTTTATATAGGTAAAACATGTTAATAGGGAAGAGTACAAGCTCTCTTACATATAAGAGGGCTCTACTATCTCCTTGGAATCCACATT
TGGGTTAACTCCTCAGATTTGGAGTGGCAAGGATAAAAGTGAGGGCAGAAGTAGCTGTGGGAAAAGATGAGCTATGATAATGCTGGGAAG
GCAGAGATTGATTAAGTGCATGCTTTGAAATAGGTTTTTAATGATGTGCCCCAAAGGGCCAGCTGATTCTGGTACTAGATTGTCAGAGTT
TTCTACCAACTGGCATCTGTGATGTCAGAGATCATTGTAAAAATGGCTTTTAGACGTGAAACAGGGTTGCCAACCCATTTGTATGACTTC
AACAACGTCAAGGAGGGCATTTAGAATTTAGAATCTGAGCACATCACACCAGCACCAGCTCCCTGTCTCTTCTAGCCACTTAATGGAGAC
ACAATGGAGAGGTAAGACAGACCACAAACTAGTTCTTATAGTGTACTCCACCTTTTACTTTTTTCCTGAGACAAATCTACCCTTATTCTT
TCTTCCTCTTCCTTACCCCTTGCAGTAGGGAGGTATCAAGGAGCATAATTAAACTTGTCAATACGGAAAGTTGTTTTTTCTAACACAACA
AAGTGGGACCATCTCTATTCCCATCTAAGCCACTCAAATTGCTGAGTGCTATTAGAACACAGCTTATTACATGGATATGGGGACAGGAGA
GATTAAAGCAGGTTCAAAAACACATGAACTGCAGATGCCATAGGCCTCAAATCAGCTGTAATTCTAGGAGACACGTGTTGATCTAGTTAT
CTAACATTGTTGTTATAAGAAAATGAGTTTACTGCATTTTTCAATCCAGATTCTTGAAATTGTCTAACATGTGGGTACTGTGTCATCACA
AAATCTCTCAGTAAGGCTATATGTGATCCTCATTTTGCCTCTTGGGAAATTAGCAGATAGTCTTTGCTCTAAATGATATCTGAGTAAATA
GACTTGAGGAATCCTCTACCACAGTGTCCCTGAAACCACATGCATCATTCAGGAAGCCTTCACCCTGTGACTATTCAGCCTCCCTGAATA
TGCTTTCTCTATAGAACCACTAACATATGGCTATTGCTCTATGATTTTTTTTTTTACATTAGGAGGCAGTGATATTGTGGAAGATTGAAA
TCCACAGATAATTCATGACCCTCATCTTATCACTTTACTCCATCTTTTTATCCTATTAAATTATTTTTGACAAGATGTCCTGGTAGACTA
AAGGTGAACAGATTTGCTCTTGCTCATCTTCTGGTGGATATTTTAACTTGCTATTCACAATCAGGACAACCAAAGTCAAGGACCCAGATG
AACCACAAGGCAGCTAGTCAGCTACTTAGAGGTTGGTTACATTCGAATAAAAAGTAGTCAGGGAATGGGGGAGGTGGGGAGTTGGGGAGT
ACTTGGCAGTTGGGATATGATCCATTTTTTTAAACAAGTTTTTTGTAGATCCCTTGTAAAATAATAATAATAATGTTGTGAATCTCCATG
CCAAGTGAAAAAGGCCTAAAGATGAGTTGAATTTGTGATACCATGGGTAAGGCATGGAAGAACTCTTGAATGTGTTGGCCATTTTCTCTA
ACTAACATGTGGTATGTATGGTCCCCTATATTAGATAGAAGTCTTTGCTACATGTAATTCAAAAGCATCTCGCTTTTCTCAGGAACCAAA
GGCTTATGATGTAGGACAAAGAAATCATCTTAGAACTGTCAAGCATATTTTCACAATACCATGTCAAGATCAGGAAAACACCCTTTTGCT
AGTGTGCTTAACTTATTTATTTCTTCTAGGAAACAATAGATAAACAGCATGAAAATGTAAATCATCTGGCATCACTGATAGAATTTCTGA
AAGAGAAAGAGAAGTAGATGGTCAACCAGTCACTAGTTGGTTGGCATGAGGTGGTGTGCAGAGGAAAGCTGCATTCACTATTGAGTAAAA
ACTTGTAGAAAGCACATTATAGAGCTTATGTTGGAATCCATCTTGGAGGATTTTTGTTTTAAACTGTCTTTAGCATTTTCCCTCTTCCCT
TCTAATGGGCATTATAATTGTTTCATCTACTCTGTGAATCTACATAGGTCTTTTTTTTTAGATGTTTGATACATTTTAAGTATTTTTAAA
TAGATGAAAATTCTAAATGATTTTCCCTCAAATCTATCTAGATTATTTTAAGATGAGACAAGATTATTGTCAATCCCTGAATGTCTGGAG
TTACCTCCCATGGATTTTTTTTTCCTTTGGCCTGGGTTTTATAAACAACTTGAACATCATATCATATAGGATAACAAAGGAGGAAGTTAA
CTTAATTCACCTCAGACTTCAGCCTAAGATTCAATCAAATTCATCCTTCAGCCTGTCTTGTTTCTTCTTTATGTTTCTTTTACTTATTGC
TGCTAGGATCCTACATAGGATTTCTATAGAAATGTATGAAATTCTGTGGTCACTGCATGTCAGGATTGCACAGTATGTTACAATACAATT
TCAAAGAGAACCCACATTTGTGAGATTTACAGACCAAGGTGTGGTGGAGGAGGTAGAATTGCAGATCAGATAAAAAGTGAGCTTACACTT
GAACTTAGTTATTCACTGTGACCTAAATTTAGTCCTATTGTAATATGTGCCTGTCACAACACAAATACCCCTCTTGAAAGAGATTTACTC
ATCTATCCAAGCACTTAATTTGGAAATTTTATTGTCCTATTGCAAAATGAAACAAAATTAAAAGTGGCCTCGAGTACTTGGTAAGTTACT
TAAAATTTTTACAAAAATATCCCACTCAATGCCAAATCTTTCAGTCCTCAAAGGCATTTAAGTCCAATAGTCATGCTTTAAATATGGCTT
TAAATTATGCCACCAAAATGGTGCACTTCACAGATTCACCAGACTGTAGCATCATAAAGTTAATTTACAGTTTTTACAACATTGCTTCTA
CATTCTTACTGGTTTACATTAAAATCCTTTAAGCCAAAAGGAAGCTTGCTCTATGGATTTAAATGCAAACTTCATTTACCAGTGCAGGAA
GTCTCATAAAACTCAGATGTACTCCCACAAAAATTTTATTGGCCTTTTTGTAAGAGATGAAAAAGAATTGACACAGTTCTCTTTAAAGAG
AAGAACTTTTTTATTATTATTTTTATCTCCAACTGCAGGTGGTGTCTTTTGCCAAGGTCTCTGTATTTTTCTTTCAGTTGTCTTTGGGAG
GGGATGTTAAGTCAAATCACTAAAACAGGGTTCTCTTTGGATTAAAAGTTCTGGATTTATTGCAACTATTTTCCTTGAGAAACATTCTCA
GCATCAGGATTGATAAACAAATGTAGATGATTAAAATAGGATAATTGGTTTTAGATAATATCTTCTACTGCCAAACTTCTGGCAAATTTA
CCTGTGAATTTCAAAATGTTATAAAATCTCTTGATATGCTTTTGTTTTTCCTTTTAGCCATTTTCTCTTCAATTTCTTAGTCCCTCTGCC
CTCTGTAAATGTGTTGAGTGATATAGCTATCAGATGTATTGAAGGCAAAGTTCTCGCAGAGGTCTCTGTTCCAGCTCTGTAAAGGTCACA
GGAATCGTGAAGGAGCTGAGAAATCTTCCTCTCCGGCCCACTGTCTGTGGCCCATTGTCATTGTTTCCTCATGAAACATTGCAGAGTTTG
AATCCTCAGTAACTCTCATTGACTGGATTAGAGGTGATGGCCACAGCAAATGGGAGAGCAAAATGTTGGCCTACAGAGAATGACACAATT
TTATTCGCCTTTGGTGTTAGTTGCCATAGTGCTGTATTTGAAAATCGATGCTTTAGCCAAAAGCTGAATGACCACCGTTTCCGTAGTTTC

>81547_81547_10_SHANK1-UNC5D_SHANK1_chr19_51214628_ENST00000359082_UNC5D_chr8_35541065_ENST00000453357_length(amino acids)=1122AA_BP=359
MTHSPATSEDEERHSASECPEGGSESDSSPDGPGRGPRGTRGQGSGAPGSLASVRGLQGRSMSVPDDAHFSMMVFRIGIPDLHQTKCLRF
NPDATIWTAKQQVLCALSESLQDVLNYGLFQPATSGRDANFLEEERLLREYPQSFEKGVPYLEFRYKTRVYKQTNLDEKQLAKLHTKTGL
KKFLEYVQLGTSDKVARLLDKGLDPNYHDSDSGETPLTLAAQTEGSVEVIRTLCLGGAHIDFRARDGMTALHKAACARHCLALTALLDLG
GSPNYKDRRGLTPLFHTAMVGGDPRCCELLLFNRAQLGIADENGWQEIHQACQRGHSQHLEHLLFYGAEPGAQNASGNTALHICALYNKV
EWLKNEEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWSSWTEWSACNVRCGRGWQKRSRTCTN
PAPLNGGAFCEGMSVQKITCTSLCPVDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKP
QSIENASDIALYSGLGAAVVAVAVLVIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQGNSLLLNSAMQPDLTVSRTYSGPICLQ
DPLDKELMTESSLFNPLSDIKVKVQSSFMVSLGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLSSLPTRTELRTTGVFGHL
GGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSLQSDGSEVLLSPEVTCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQ
GKWEEVMSVEDESTSCYCLLDPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQEVVSDERHQG
GQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCSNRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQ
TSILESERETITFFAQEDSTFPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVILNLWEARHQH

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Fusion Gene PPI Analysis for SHANK1-UNC5D


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SHANK1-UNC5D


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SHANK1-UNC5D


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource