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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:SHANK3-MAPK1 (FusionGDB2 ID:81611) |
Fusion Gene Summary for SHANK3-MAPK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SHANK3-MAPK1 | Fusion gene ID: 81611 | Hgene | Tgene | Gene symbol | SHANK3 | MAPK1 | Gene ID | 85358 | 5594 |
| Gene name | SH3 and multiple ankyrin repeat domains 3 | mitogen-activated protein kinase 1 | |
| Synonyms | DEL22q13.3|PROSAP2|PSAP2|SCZD15|SPANK-2 | ERK|ERK-2|ERK2|ERT1|MAPK2|P42MAPK|PRKM1|PRKM2|p38|p40|p41|p41mapk|p42-MAPK | |
| Cytomap | 22q13.33 | 22q11.22 | |
| Type of gene | protein-coding | protein-coding | |
| Description | SH3 and multiple ankyrin repeat domains protein 3proline rich synapse associated protein 2shank postsynaptic density protein | mitogen-activated protein kinase 1MAP kinase 1MAP kinase 2MAP kinase isoform p42MAPK 2extracellular signal-regulated kinase 2mitogen-activated protein kinase 2protein tyrosine kinase ERK2 | |
| Modification date | 20200320 | 20200327 | |
| UniProtAcc | . | Q8NDC0 | |
| Ensembl transtripts involved in fusion gene | ENST00000262795, ENST00000414786, ENST00000445220, | ENST00000491588, ENST00000215832, ENST00000398822, ENST00000544786, | |
| Fusion gene scores | * DoF score | 8 X 5 X 4=160 | 15 X 8 X 9=1080 |
| # samples | 7 | 16 | |
| ** MAII score | log2(7/160*10)=-1.1926450779424 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/1080*10)=-2.75488750216347 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SHANK3 [Title/Abstract] AND MAPK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | SHANK3(51115121)-MAPK1(22153417), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MAPK1 | GO:0006468 | protein phosphorylation | 23184662 |
| Tgene | MAPK1 | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation | 16314496 |
| Tgene | MAPK1 | GO:0018105 | peptidyl-serine phosphorylation | 15850461 |
| Tgene | MAPK1 | GO:0034198 | cellular response to amino acid starvation | 11096076 |
| Tgene | MAPK1 | GO:0038127 | ERBB signaling pathway | 15133037 |
| Tgene | MAPK1 | GO:0051403 | stress-activated MAPK cascade | 11096076 |
| Tgene | MAPK1 | GO:0070371 | ERK1 and ERK2 cascade | 16314496 |
| Tgene | MAPK1 | GO:0070849 | response to epidermal growth factor | 18794356 |
| Fusion gene breakpoints across SHANK3 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across MAPK1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SKCM | TCGA-D3-A1Q3-06A | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
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Fusion Gene ORF analysis for SHANK3-MAPK1 |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000262795 | ENST00000491588 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
| 5CDS-intron | ENST00000414786 | ENST00000491588 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
| 5CDS-intron | ENST00000445220 | ENST00000491588 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
| In-frame | ENST00000262795 | ENST00000215832 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
| In-frame | ENST00000262795 | ENST00000398822 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
| In-frame | ENST00000262795 | ENST00000544786 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
| In-frame | ENST00000414786 | ENST00000215832 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
| In-frame | ENST00000414786 | ENST00000398822 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
| In-frame | ENST00000414786 | ENST00000544786 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
| In-frame | ENST00000445220 | ENST00000215832 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
| In-frame | ENST00000445220 | ENST00000398822 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
| In-frame | ENST00000445220 | ENST00000544786 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000414786 | SHANK3 | chr22 | 51115121 | + | ENST00000215832 | MAPK1 | chr22 | 22153417 | - | 10907 | 566 | 227 | 1156 | 309 |
| ENST00000414786 | SHANK3 | chr22 | 51115121 | + | ENST00000398822 | MAPK1 | chr22 | 22153417 | - | 1321 | 566 | 227 | 1156 | 309 |
| ENST00000414786 | SHANK3 | chr22 | 51115121 | + | ENST00000544786 | MAPK1 | chr22 | 22153417 | - | 1025 | 566 | 227 | 1024 | 266 |
| ENST00000445220 | SHANK3 | chr22 | 51115121 | + | ENST00000215832 | MAPK1 | chr22 | 22153417 | - | 10680 | 339 | 0 | 929 | 309 |
| ENST00000445220 | SHANK3 | chr22 | 51115121 | + | ENST00000398822 | MAPK1 | chr22 | 22153417 | - | 1094 | 339 | 0 | 929 | 309 |
| ENST00000445220 | SHANK3 | chr22 | 51115121 | + | ENST00000544786 | MAPK1 | chr22 | 22153417 | - | 798 | 339 | 0 | 797 | 265 |
| ENST00000262795 | SHANK3 | chr22 | 51115121 | + | ENST00000215832 | MAPK1 | chr22 | 22153417 | - | 10680 | 339 | 0 | 929 | 309 |
| ENST00000262795 | SHANK3 | chr22 | 51115121 | + | ENST00000398822 | MAPK1 | chr22 | 22153417 | - | 1094 | 339 | 0 | 929 | 309 |
| ENST00000262795 | SHANK3 | chr22 | 51115121 | + | ENST00000544786 | MAPK1 | chr22 | 22153417 | - | 798 | 339 | 0 | 797 | 265 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000414786 | ENST00000215832 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - | 0.000713368 | 0.9992867 |
| ENST00000414786 | ENST00000398822 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - | 0.001742059 | 0.99825794 |
| ENST00000414786 | ENST00000544786 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - | 0.001695268 | 0.9983047 |
| ENST00000445220 | ENST00000215832 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - | 0.000663222 | 0.9993368 |
| ENST00000445220 | ENST00000398822 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - | 0.001462984 | 0.99853706 |
| ENST00000445220 | ENST00000544786 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - | 0.001251361 | 0.99874866 |
| ENST00000262795 | ENST00000215832 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - | 0.000663222 | 0.9993368 |
| ENST00000262795 | ENST00000398822 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - | 0.001462984 | 0.99853706 |
| ENST00000262795 | ENST00000544786 | SHANK3 | chr22 | 51115121 | + | MAPK1 | chr22 | 22153417 | - | 0.001251361 | 0.99874866 |
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Fusion Genomic Features for SHANK3-MAPK1 |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page. |
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Fusion Protein Features for SHANK3-MAPK1 |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:51115121/chr22:22153417) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | MAPK1 |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | 2 | 9 | 259_277 | 164 | 3486.3333333333335 | DNA binding | . | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | 2 | 8 | 259_277 | 164 | 361.0 | DNA binding | . | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | 2 | 7 | 259_277 | 164 | 317.0 | DNA binding | . | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | 2 | 9 | 185_187 | 164 | 3486.3333333333335 | Motif | TXY | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | 2 | 9 | 318_322 | 164 | 3486.3333333333335 | Motif | Cytoplasmic retention motif | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | 2 | 9 | 327_333 | 164 | 3486.3333333333335 | Motif | Nuclear translocation motif | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | 2 | 8 | 185_187 | 164 | 361.0 | Motif | TXY | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | 2 | 8 | 318_322 | 164 | 361.0 | Motif | Cytoplasmic retention motif | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | 2 | 8 | 327_333 | 164 | 361.0 | Motif | Nuclear translocation motif | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | 2 | 7 | 185_187 | 164 | 317.0 | Motif | TXY | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | 2 | 7 | 318_322 | 164 | 317.0 | Motif | Cytoplasmic retention motif | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | 2 | 7 | 327_333 | 164 | 317.0 | Motif | Nuclear translocation motif |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | 2 | 9 | 2_9 | 164 | 3486.3333333333335 | Compositional bias | Note=Poly-Ala | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | 2 | 8 | 2_9 | 164 | 361.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | 2 | 7 | 2_9 | 164 | 317.0 | Compositional bias | Note=Poly-Ala | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | 2 | 9 | 25_313 | 164 | 3486.3333333333335 | Domain | Protein kinase | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | 2 | 8 | 25_313 | 164 | 361.0 | Domain | Protein kinase | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | 2 | 7 | 25_313 | 164 | 317.0 | Domain | Protein kinase | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | 2 | 9 | 31_39 | 164 | 3486.3333333333335 | Nucleotide binding | ATP | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | 2 | 8 | 31_39 | 164 | 361.0 | Nucleotide binding | ATP | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | 2 | 7 | 31_39 | 164 | 317.0 | Nucleotide binding | ATP | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | 2 | 9 | 105_108 | 164 | 3486.3333333333335 | Region | Note=Inhibitor-binding | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000215832 | 2 | 9 | 153_154 | 164 | 3486.3333333333335 | Region | Note=Inhibitor-binding | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | 2 | 8 | 105_108 | 164 | 361.0 | Region | Note=Inhibitor-binding | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000398822 | 2 | 8 | 153_154 | 164 | 361.0 | Region | Note=Inhibitor-binding | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | 2 | 7 | 105_108 | 164 | 317.0 | Region | Note=Inhibitor-binding | |
| Tgene | MAPK1 | chr22:51115121 | chr22:22153417 | ENST00000544786 | 2 | 7 | 153_154 | 164 | 317.0 | Region | Note=Inhibitor-binding |
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Fusion Gene Sequence for SHANK3-MAPK1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >81611_81611_1_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000262795_MAPK1_chr22_22153417_ENST00000215832_length(transcript)=10680nt_BP=339nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT GCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGACAAGGGCTCAGAGGACTGGACGTGCTCAGACATCGGTGTTCTTCTTCCC AGTTCTTGACCCCTGGTCCTGTCTCCAGCCCGTCTTGGCTTATCCACTTTGACTCCTTTGAGCCGTTTGGAGGGGCGGTTTCTGGTAGTT GTGGCTTTTATGCTTTCAAAGAATTTCTTCAGTCCAGAGAATTCCTCCTGGCAGCCCTGTGTGTGTCACCCATTGGTGACCTGCGGCAGT ATGTACTTCAGTGCACCTACTGCTTACTGTTGCTTTAGTCACTAATTGCTTTCTGGTTTGAAAGATGCAGTGGTTCCTCCCTCTCCTGAA TCCTTTTCTACATGATGCCCTGCTGACCATGCAGCCGCACCAGAGAGAGATTCTTCCCCAATTGGCTCTAGTCACTGGCATCTCACTTTA TGATAGGGAAGGCTACTACCTAGGGCACTTTAAGTCAGTGACAGCCCCTTATTTGCACTTCACCTTTTGACCATAACTGTTTCCCCAGAG CAGGAGCTTGTGGAAATACCTTGGCTGATGTTGCAGCCTGCAGCAAGTGCTTCCGTCTCCGGAATCCTTGGGGAGCACTTGTCCACGTCT TTTCTCATATCATGGTAGTCACTAACATATATAAGGTATGTGCTATTGGCCCAGCTTTTAGAAAATGCAGTCATTTTTCTAAATAAAAAG GAAGTACTGCACCCAGCAGTGTCACTCTGTAGTTACTGTGGTCACTTGTACCATATAGAGGTGTAACACTTGTCAAGAAGCGTTATGTGC AGTACTTAATGTTTGTAAGACTTACAAAAAAAGATTTAAAGTGGCAGCTTCACTCGACATTTGGTGAGAGAAGTACAAAGGTTGCAGTGC TGAGCTGTGGGCGGTTTCTGGGGATGTCCCAGGGTGGAACTCCACATGCTGGTGCATATACGCCCTTGAGCTACTTCAAATGTGGGTGTT TCAGTAACCACGTTCCATGCCTGAGGATTTAGCAGAGAGGAACACTGCGTCTTTAAATGAGAAAGTATACAATTCTTTTTCCTTCTACAG CATGTCAGCATCTCAAGTTCATTTTTCAACCTACAGTATAACAATTTGTAATAAAGCCTCCAGGAGCTCATGACGTGAAGCACTGTTCTG TCCTCAAGTACTCAAATATTTCTGATACTGCTGAGTCAGACTGTCAGAAAAAGCTAGCACTAACTCGTGTTTGGAGCTCTATCCATATTT TACTGATCTCTTTAAGTATTTGTTCCTGCCACTGTGTACTGTGGAGTTGACTCGGTGTTCTGTCCCAGTGCGGTGCCTCCTCTTGACTTC CCCACTGCTCTCTGTGGTGAGAAATTTGCCTTGTTCAATAATTACTGTACCCTCGCATGACTGTTACAGCTTTCTGTGCAGAGATGACTG TCCAAGTGCCACATGCCTACGATTGAAATGAAAACTCTATTGTTACCTCTGAGTTGTGTTCCACGGAAAATGCTATCCAGCAGATCATTT AGGAAAAATAATTCTATTTTTAGCTTTTCATTTCTCAGCTGTCCTTTTTTCTTGTTTGATTTTTGACAGCAATGGAGAATGGGTTATATA AAGACTGCCTGCTAATATGAACAGAAATGCATTTGTAATTCATGAAAATAAATGTACATCTTCTATCTTCACATTCATGTTAAGATTCAG TGTTGCTTTCCTCTGGATCAGCGTGTCTGAATGGACAGTCAGGTTCAGGTTGTGCTGAACACAGAAATGCTCACAGGCCTCACTTTGCCG CCCAGGCACTGGCCCAGCACTTGGATTTACATAAGATGAGTTAGAAAGGTACTTCTGTAGGGTCCTTTTTACCTCTGCTCGGCAGAGAAT CGATGCTGTCATGTTCCTTTATTCACAATCTTAGGTCTCAAATATTCTGTCAAACCCTAACAAAGAAGCCCCGACATCTCAGGTTGGATT CCCTGGTTCTCTCTAAAGAGGGCCTGCCCTTGTGCCCCAGAGGTGCTGCTGGGCACAGCCAAGAGTTGGGAAGGGCCGCCCCACAGTACG CAGTCCTCACCACCCAGCCCAGGGTGCTCACGCTCACCACTCCTGTGGCTGAGGAAGGATAGCTGGCTCATCCTCGGAAAACAGACCCAC ATCTCTATTCTTGCCCTGAAATACGCGCTTTTCACTTGCGTGCTCAGAGCTGCCGTCTGAAGGTCCACACAGCATTGACGGGACACAGAA ATGTGACTGTTACCGGATAACACTGATTAGTCAGTTTTCATTTATAAAAAAGCATTGACAGTTTTATTACTCTTGTTTCTTTTTAAATGG AAAGTTACTATTATAAGGTTAATTTGGAGTCCTCTTCTAAATAGAAAACCATATCCTTGGCTACTAACATCTGGAGACTGTGAGCTCCTT CCCATTCCCCTTCCTGGTACTGTGGAGTCAGATTGGCATGAAACCACTAACTTCATTCTAGAATCATTGTAGCCATAAGTTGTGTGCTTT TTATTAATCATGCCAAACATAATGTAACTGGGCAGAGAATGGTCCTAACCAAGGTACCTATGAAAAGCGCTAGCTATCATGTGTAGTAGA TGCATCATTTTGGCTCTTCTTACATTTGTAAAAATGTACAGATTAGGTCATCTTAATTCATATTAGTGACACGGAACAGCACCTCCACTA TTTGTATGTTCAAATAAGCTTTCAGACTAATAGCTTTTTTGGTGTCTAAAATGTAAGCAAAAAATTCCTGCTGAAACATTCCAGTCCTTT CATTTAGTATAAAAGAAATACTGAACAAGCCAGTGGGATGGAATTGAAAGAACTAATCATGAGGACTCTGTCCTGACACAGGTCCTCAAA GCTAGCAGAGATACGCAGACATTGTGGCATCTGGGTAGAAGAATACTGTATTGTGTGTGCAGTGCACAGTGTGTGGTGTGTGCACACTCA TTCCTTCTGCTCTTGGGCACAGGCAGTGGGTGTAGAGGTAACCAGTAGCTTTGAGAAGCTACATGTAGCTCACCAGTGGTTTTCTCTAAG GAATCACAAAAGTAAACTACCCAACCACATGCCACGTAATATTTCAGCCATTCAGAGGAAACTGTTTTCTCTTTATTTGCTTATATGTTA ATATGGTTTTTAAATTGGTAACTTTTATATAGTATGGTAACAGTATGTTAATACACACATACATACGCACACATGCTTTGGGTCCTTCCA TAATACTTTTATATTTGTAAATCAATGTTTTGGAGCAATCCCAAGTTTAAGGGAAATATTTTTGTAAATGTAATGGTTTTGAAAATCTGA GCAATCCTTTTGCTTATACATTTTTAAAGCATTTGTGCTTTAAAATTGTTATGCTGGTGTTTGAAACATGATACTCCTGTGGTGCAGATG AGAAGCTATAACAGTGAATATGTGGTTTCTCTTACGTCATCCACCTTGACATGATGGGTCAGAAACAAATGGAAATCCAGAGCAAGTCCT CCAGGGTTGCACCAGGTTTACCTAAAGCTTGTTGCCTTTTCTTGTGCTGTTTATGCGTGTAGAGCACTCAAGAAAGTTCTGAAACTGCTT TGTATCTGCTTTGTACTGTTGGTGCCTTCTTGGTATTGTACCCCAAAATTCTGCATAGATTATTTAGTATAATGGTAAGTTAAAAAATGT TAAAGGAAGATTTTATTAAGAATCTGAATGTTTATTCATTATATTGTTACAATTTAACATTAACATTTATTTGTGGTATTTGTGATTTGG TTAATCTGTATAAAAATTGTAAGTAGAAAGGTTTATATTTCATCTTAATTCTTTTGATGTTGTAAACGTACTTTTTAAAAGATGGATTAT TTGAATGTTTATGGCACCTGACTTGTAAAAAAAAAAAACTACAAAAAAATCCTTAGAATCATTAAATTGTGTCCCTGTATTACCAAAATA ACACAGCACCGTGCATGTATAGTTTAATTGCAGTTTCATCTGTGAAAACGTGAAATTGTCTAGTCCTTCGTTATGTTCCCCAGATGTCTT CCAGATTTGCTCTGCATGTGGTAACTTGTGTTAGGGCTGTGAGCTGTTCCTCGAGTTGAATGGGGATGTCAGTGCTCCTAGGGTTCTCCA GGTGGTTCTTCAGACCTTCACCTGTGGGGGGGGGGGTAGGCGGTGCCCACGCCCATCTCCTCATCCTCCTGAACTTCTGCAACCCCACTG CTGGGCAGACATCCTGGGCAACCCCTTTTTTCAGAGCAAGAAGTCATAAAGATAGGATTTCTTGGACATTTGGTTCTTATCAATATTGGG CATTATGTAATGACTTATTTACAAAACAAAGATACTGGAAAATGTTTTGGATGTGGTGTTATGGAAAGAGCACAGGCCTTGGACCCATCC AGCTGGGTTCAGAACTACCCCCTGCTTATAACTGCGGCTGGCTGTGGGCCAGTCATTCTGCGTCTCTGCTTTCTTCCTCTGCTTCAGACT GTCAGCTGTAAAGTGGAAGCAATATTACTTGCCTTGTATATGGTAAAGATTATAAAAATACATTTCAACTGTTCAGCATAGTACTTCAAA GCAAGTACTCAGTAAATAGCAAGTCTTTTTAAATGCTGCTTTATTTCACTAAATTTTGTTGTGAGGTGTCACTAAAATGCCTGCAAACAA ACGTAACTGCTAATCTGAGAGGAAACCCTCTTACTAATCAGAGAAGAAACCCTCCTGTCAGAAACCTTCAGGGAAGTGAGCTGATCACAC CTAAACTGGGAGTTTGCAATGGGGTATTTGAAGCACTGTGGGAGTATTCCACTGGCCCTCTCCCTGAGAGACTTAACAGTCTTCCCTGTT GTCCAGATTCTGTATAAGGCAATCAGAATAATCATCTTCCTTGTTCAGCAGAGGAGCCTGGTCCCATTTTCCCCACTTTGTGATGGGCTT CTCTCAGCGGTAGCTCAGCAGTTCCAGATGGCAGTTTGGACCAGCATCTAGGCTGGCCAGTTCGCTGTGTTTACTTAGAACCAACACGTT CAGAGCTGGCCTGGACCATCTGAGGGGAACAGGAAACACCCCTAGGCTGTGGAAGCAAGTGCAGACCCCCACCCCCGGCCCTGAAGCCAA GGGGGCAGGGTTTGGGAGTGGCCAAAGAGAAGCAGTGCAGGGATGGGTTTTCCTAGGGACAGGCTTAGCATTCCTGACTCTAGGAAGAAG GAGCAGTGAGGCGGAGAAACAGTGGAGGGGATGGTGGCATTGGGCCCCATGGGGCCGAGATGGACACAGGGCTCGTTCTCTTGAGTCTGG TGCCAAGGACAGCTGAAGACGACATCATTTTCAGGTGGAGAGGAGAGAGTGGAGGGAGATCATGCCCTGTGATGTGTCTTTTGCAGGTGA AGGTGGGAGACAAGGTCTCTGCTGACGATGAGGCAGAGCCACCGTGAAAGTTGTAATAGGAGGACTGCCCGCCGCTGGAAGGGCCTGCAG TGACGCTAGGACACCCTCTGCCTGCATGTCACGTTAGCTGGGCTGGGCGAAGTAGAAGACCAAGGGGAAGAGGTGCAGTGGGGAGACCAG GTGGGATGCAACCACAGGACCAGTGGAGGGGCTGTGGCACGTGGGCGGAGACTGAGTGGCTGGGCATGTGTTGTGGCTGAGCATGTGGTG TGGGCAGTGGTCCTAGACCCCGCCATGTCCGGACAATGATATAGAGCGTCTCAGCATCGCCAGTCTAGACTGTCTATGGAGAGCAGAAAG TTGTCTGGGGCTGCCTGGGGAACTGTGAGGCCAGCTATATCACCGTCGCTGATGGTGACATTACGGTGGTGGCAGGAGCAAGGAGAGAGG GAAGAAGGACCCCGTCCAGCTTTAGTCACAAAATACCCAATGGAAGATGCCAGTGCCAATCCTGTGGGTTTCCTTGGGACTTCACACTGG CTTTCTTATCTGCTCCAGATCCATTCAGTAGTCACTGAGTTCCTGCCAAATACTTTGTAGCGCCAGAAGCCAGGAGCGGGGTCTGCAGCA GGGCAGTCCCCATTTTCAGGAAATGCCTGGAGCTGCTGGTCCCTGAGAGAAAGGAAAACATCTTTCAGCCGTACGCAGGCCAAGAAGGCC AATGTCCAGTAGCTTTGTGATTTTTTTTATATTTTTTTATTTATTTATTTTTGAGATAGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCA GTGGCGTGATCTCCACTCACTGCAACTTCCGCCTCCTGGGGTCAAGCAGTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACAC GCCACCACACCCAGCTAATTTTTGTGTTTTTAGTAGAGACGGTTTCACCATGTCGGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGAT TCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCCAGCCTGTGATGTTTCTGTGGGGTTCCACAAATGTGTGTGTGTGT AAAAGCTGATGATTACAGCAAGAATGTGAACAGTAGCAGTTTTCCATTTGAAGGCAAGTTTTGTCTTTATCTGGGTATCAGAAGGACCCT CTGGGCCATTGTCGCTTCCTGTACTCAGAGCCACCCTAGTACTACGGGCACACACAGAAAACAGCAGCCTGCGTACTTTCAAAGGAAAGG CATCTTTAATCACCAATGCCTGGAAAAATTATTTTGTTTCCCTCTTCCTTCCGTCTTGTTTCCTAACTTCTTACCAAAGTTTAGAGTCTG AGTTTTTCGTATAATAATGTCCCACATCCACACATCGGGCCTACAGATGCTCTCCCTTGAATCGACTGGAAACATGACACCGGTTCCATG CTCTGGAACTGTCACCTGTGATGTGCTGGGCTGTGTCCCAAGCACAGGAATCCCAGCAGTTTCAGCTCGATGCAGAACCACCATGCTCCA GACACAGGCTTGGGAAAGACACGTCAAAATTAAAATACTAGGTAAGAGAAGCACCTGATTGGGTAGAAGTTGGAGAGGAATCCTGGAATT TTGTGGCCAGAAGGAGCCACTGCCCCTTTTGTTTAGTAAGACTAGACAGTAACAGAAGCCAGTTGTCAGCTATGAAAGTGGTGGGTGAAG CAGGGGAGGCTCCTCTATGGTGGGACCCTGGACAAGGGAAGCCGAATGTGTGAAGAAGGGGTGCGGGGGTGTGCGGTGCCCTAGGACACT AGGGCAAAGGTTTCAAACCTGGAACAAGGCACTGGAGGAAGATCTGCTGCCAGTCAGCAGTGCGGGCCCTCGAGTTAGCAGTCCGTGCGC AGAGGGGCCAGTTCTGAGACCAGTTTGGAGAGTCAGGCAGTGACCCATTGGCCATGTCATAATTCCTTCAGCCTGCCTCCTCTTTAATCC CAGAGAGTGCTCTTTCTTCATACTTCCTTTAAAATACTAAATTGTTCCCATTCCATGGGGAGCTGGCTAGGCTTTACAGGCTAGGAAATG TAGGTTTTCTGAGATGGAACCATCTACACAAGGAGGAGGAAGGCACTAAGACTACAGATGAGACCCATGACAGGGCTGAGCATTTGGAAG CCAACCCTGGTTGCTTTTCAAGAATTGCTTTGTGGCTGGGTGCAGTGGTTCACACCTGTAATTGCAGCACTTTGGGAGGCTGAGGCAGGT GGATTGCTTGAACCCAGGAGTTCGAGACCAGCCTGGGCAACATATGGGACACCCCACCGCCCCCGGCTCTGCAAAAAAATTAAAAATTAG CCAGGCGTGGTGTCATGAGCCTGTGGTCTCAACTACTCAGGAGGCTGAGGCTGGAGGATCGCTTGAACCTGGGAGGTCAAGGCTCCAGTG AACCATAATTGTGCCACTGCACTGCAGCCTGGGCGACAATTTGTTTTCTAAATTGCTTTTGAAAGTCTACTGCATTACATATTCCAAAAA GCAGTGGTTTTCAAATACTTTTATCACCGATATCCTTTTATGAAATGAAATCAGTAGAACTTTCTCTGCTCTGAATAAGCAAGGGTGGGA ACCTGTCTACCTCCCACAGATAGCATAATGTGCCTGCCATAGAGGAGCCAAAAAATGGTGATGGGAACTGAGAGGAGAGCAAATGTCACA AAAGACTGAGCAATTGAGAAAACAAAACAAGACCACAGATGACTGTTAACGCCTCCACAGTGGACCAAGAAAGGACAGAGAGCTGGCAGC ATGGGCATCACTGTCTGGTCGGCAGCAGGAAGGCCTCGCTAGGGAATTGAGTACAGTCATCTAACTAGTTTAAAAGTACAGGAAGGATGA TTAAGGCTATTGGAGAGGTCATACAAATAGGGGAGGGGCAGGCAATGGCTGATAAGACATGAATTTGTAAGGCGATGAGTATTGCAGTCA GCAAAACAAACGAGACTGCTCTCCCAACACATAACTCAGCAGGGAGGCCAGGCATTGGTTTAACCATTTAATATAAAGAAGTTAAAATTA CAAATGCGCTAAGTGCCTAAAGAAGAATAAGTGCAGGAATGAGAGCAGCATGGACTGCCACAGTTTTAGAATAAGCACTGTCACTGCTAG ATTGGAAACAAAAATCCATAAATTTGGCCCGGTGTGGTGGCGGACGCCTGTAGTCCCAGCTACTTGGAGGCTGAGGCGTGAGAATCGCTT GAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATGGCGCCACTGCACTCCAGCCTGGGCGTCAGAGTGAGAACTCTGTATCAAAAAATA AAAATAAAAAAAAGTCCATAAATCTGCAATGTCTCAGTTAAGAAAGAAAGACTGGGCCAATGCAGATTTCAAACCGGAGAAAGTCATACT GTCAGTGAAGGCCGCCTGTGGCCGGAAGGCGCCAGGGGATTAGCACCCTGGACTCAGTGTTGCTGGGAAACAGGGCCCCAAGGCTGGGAG CACAGTGTTTAAAGGGCATCTACCCAAGAAGGGAGCACAGGGCAAGGAGGAGCTGCAGGGGGGCTTGGCTGCCAAAGTGAATTCTGAGGA GAGAGCTATTGCTGCCTACGATATGCAGGCTGCACAGAACACAAGTGGAATCAGCAGGCAGGAGAGGCAGCTAACGACGCAGCCCGTTTC TTATTTCTGTTTTCTCACAAGCGATGAAAGTGGAAAAGAGGGTGAGCAGGTGGCCCACACATGTGCCTCCAGTGCTGCGGCCCCTCCGGG GACCATCAGCCAGGCCCCGGGGAGGGAGCCAGCCACAGTGTGTCCGGCTCTTCTCTGAAGGGAAGAGAGCCTTGAATAGACTGAAGCGAA GACGGTTCTGCAAGGACAAGGCAGACCGAAGGCATTGGTTTTTTTTTTCAGATAAGGAGAATTAGACTCCCAAGTAGACACCAGAGTCAC TGTTTGGTTGGTGGGTGATAGTGGGGTCACAGTGGCTGCCTGTGCTCCCCCAGGGTGAGCGTGACTGTGCTAACCTGGGTGGGGCAGCAT GCACACCCCTCTGGCAGCCCTTTGTTGCTCGCTGATGACAAGTTTGGATGATCCCGCCAAACAGCTTGCTAAGATGTAGTCCCCAGTGTT GGAGGTGGGGCCTGATGGGAGGTGCTACCCTTGTGAGATAAGGTTGTGTAAAAGCCTGTGGCACCTCCCCACACTGACGCTCTCACCCCT GCTCTGGCCATGTGCCGCGCCTGCTCCCACTTCCCCTTCTGCCAGGAGTAAAAGCCCCCGAGACCTCCCAGAAGCCAAGCAGATGCTAGT >81611_81611_1_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000262795_MAPK1_chr22_22153417_ENST00000215832_length(amino acids)=309AA_BP=113 MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD -------------------------------------------------------------- >81611_81611_2_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000262795_MAPK1_chr22_22153417_ENST00000398822_length(transcript)=1094nt_BP=339nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT GCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGTACCTGGAGTTTAATACAGTGAGCTCTAGCAAGGGAGGCGCTGCCTTTTG TTTCTAGAATATTATGTTCCTCAAGGTCCATTATTTTGTATTCTTTTCCAAGCTCCTTATTGGAAGGTATTTTTTTAAATTTAGAATTAA >81611_81611_2_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000262795_MAPK1_chr22_22153417_ENST00000398822_length(amino acids)=309AA_BP=113 MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD -------------------------------------------------------------- >81611_81611_3_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000262795_MAPK1_chr22_22153417_ENST00000544786_length(transcript)=798nt_BP=339nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAA CAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTG >81611_81611_3_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000262795_MAPK1_chr22_22153417_ENST00000544786_length(amino acids)=265AA_BP=113 MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK -------------------------------------------------------------- >81611_81611_4_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000414786_MAPK1_chr22_22153417_ENST00000215832_length(transcript)=10907nt_BP=566nt ATGCAGCTGAGCCGCGCCGCCGCCGCCGCCGCCGCCGCCCCTGCGGAGCCCCCGGAGCCGCTGTCCCCCGCGCCGGCCCCGGCCCCGGCC CCCCCCGGCCCCCTCCCGCGCAGCGCGGCCGACGGGGCTCCGGCGGGGGGGAAGGGGGGGCCGGGGCGCCGCGCGCGGAGTCCCCGGGCG CTCCGTTCCCCGGCGCGAGCGGCCCCGGCCCGGGCCCCGGCGCGGGGATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCA TCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCGCCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACC ACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCCCGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGC AGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTTCGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATA AGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAG AATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCT GCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGAT CCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGA ACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAAC AGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGG ATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGACA AGGGCTCAGAGGACTGGACGTGCTCAGACATCGGTGTTCTTCTTCCCAGTTCTTGACCCCTGGTCCTGTCTCCAGCCCGTCTTGGCTTAT CCACTTTGACTCCTTTGAGCCGTTTGGAGGGGCGGTTTCTGGTAGTTGTGGCTTTTATGCTTTCAAAGAATTTCTTCAGTCCAGAGAATT CCTCCTGGCAGCCCTGTGTGTGTCACCCATTGGTGACCTGCGGCAGTATGTACTTCAGTGCACCTACTGCTTACTGTTGCTTTAGTCACT AATTGCTTTCTGGTTTGAAAGATGCAGTGGTTCCTCCCTCTCCTGAATCCTTTTCTACATGATGCCCTGCTGACCATGCAGCCGCACCAG AGAGAGATTCTTCCCCAATTGGCTCTAGTCACTGGCATCTCACTTTATGATAGGGAAGGCTACTACCTAGGGCACTTTAAGTCAGTGACA GCCCCTTATTTGCACTTCACCTTTTGACCATAACTGTTTCCCCAGAGCAGGAGCTTGTGGAAATACCTTGGCTGATGTTGCAGCCTGCAG CAAGTGCTTCCGTCTCCGGAATCCTTGGGGAGCACTTGTCCACGTCTTTTCTCATATCATGGTAGTCACTAACATATATAAGGTATGTGC TATTGGCCCAGCTTTTAGAAAATGCAGTCATTTTTCTAAATAAAAAGGAAGTACTGCACCCAGCAGTGTCACTCTGTAGTTACTGTGGTC ACTTGTACCATATAGAGGTGTAACACTTGTCAAGAAGCGTTATGTGCAGTACTTAATGTTTGTAAGACTTACAAAAAAAGATTTAAAGTG GCAGCTTCACTCGACATTTGGTGAGAGAAGTACAAAGGTTGCAGTGCTGAGCTGTGGGCGGTTTCTGGGGATGTCCCAGGGTGGAACTCC ACATGCTGGTGCATATACGCCCTTGAGCTACTTCAAATGTGGGTGTTTCAGTAACCACGTTCCATGCCTGAGGATTTAGCAGAGAGGAAC ACTGCGTCTTTAAATGAGAAAGTATACAATTCTTTTTCCTTCTACAGCATGTCAGCATCTCAAGTTCATTTTTCAACCTACAGTATAACA ATTTGTAATAAAGCCTCCAGGAGCTCATGACGTGAAGCACTGTTCTGTCCTCAAGTACTCAAATATTTCTGATACTGCTGAGTCAGACTG TCAGAAAAAGCTAGCACTAACTCGTGTTTGGAGCTCTATCCATATTTTACTGATCTCTTTAAGTATTTGTTCCTGCCACTGTGTACTGTG GAGTTGACTCGGTGTTCTGTCCCAGTGCGGTGCCTCCTCTTGACTTCCCCACTGCTCTCTGTGGTGAGAAATTTGCCTTGTTCAATAATT ACTGTACCCTCGCATGACTGTTACAGCTTTCTGTGCAGAGATGACTGTCCAAGTGCCACATGCCTACGATTGAAATGAAAACTCTATTGT TACCTCTGAGTTGTGTTCCACGGAAAATGCTATCCAGCAGATCATTTAGGAAAAATAATTCTATTTTTAGCTTTTCATTTCTCAGCTGTC CTTTTTTCTTGTTTGATTTTTGACAGCAATGGAGAATGGGTTATATAAAGACTGCCTGCTAATATGAACAGAAATGCATTTGTAATTCAT GAAAATAAATGTACATCTTCTATCTTCACATTCATGTTAAGATTCAGTGTTGCTTTCCTCTGGATCAGCGTGTCTGAATGGACAGTCAGG TTCAGGTTGTGCTGAACACAGAAATGCTCACAGGCCTCACTTTGCCGCCCAGGCACTGGCCCAGCACTTGGATTTACATAAGATGAGTTA GAAAGGTACTTCTGTAGGGTCCTTTTTACCTCTGCTCGGCAGAGAATCGATGCTGTCATGTTCCTTTATTCACAATCTTAGGTCTCAAAT ATTCTGTCAAACCCTAACAAAGAAGCCCCGACATCTCAGGTTGGATTCCCTGGTTCTCTCTAAAGAGGGCCTGCCCTTGTGCCCCAGAGG TGCTGCTGGGCACAGCCAAGAGTTGGGAAGGGCCGCCCCACAGTACGCAGTCCTCACCACCCAGCCCAGGGTGCTCACGCTCACCACTCC TGTGGCTGAGGAAGGATAGCTGGCTCATCCTCGGAAAACAGACCCACATCTCTATTCTTGCCCTGAAATACGCGCTTTTCACTTGCGTGC TCAGAGCTGCCGTCTGAAGGTCCACACAGCATTGACGGGACACAGAAATGTGACTGTTACCGGATAACACTGATTAGTCAGTTTTCATTT ATAAAAAAGCATTGACAGTTTTATTACTCTTGTTTCTTTTTAAATGGAAAGTTACTATTATAAGGTTAATTTGGAGTCCTCTTCTAAATA GAAAACCATATCCTTGGCTACTAACATCTGGAGACTGTGAGCTCCTTCCCATTCCCCTTCCTGGTACTGTGGAGTCAGATTGGCATGAAA CCACTAACTTCATTCTAGAATCATTGTAGCCATAAGTTGTGTGCTTTTTATTAATCATGCCAAACATAATGTAACTGGGCAGAGAATGGT CCTAACCAAGGTACCTATGAAAAGCGCTAGCTATCATGTGTAGTAGATGCATCATTTTGGCTCTTCTTACATTTGTAAAAATGTACAGAT TAGGTCATCTTAATTCATATTAGTGACACGGAACAGCACCTCCACTATTTGTATGTTCAAATAAGCTTTCAGACTAATAGCTTTTTTGGT GTCTAAAATGTAAGCAAAAAATTCCTGCTGAAACATTCCAGTCCTTTCATTTAGTATAAAAGAAATACTGAACAAGCCAGTGGGATGGAA TTGAAAGAACTAATCATGAGGACTCTGTCCTGACACAGGTCCTCAAAGCTAGCAGAGATACGCAGACATTGTGGCATCTGGGTAGAAGAA TACTGTATTGTGTGTGCAGTGCACAGTGTGTGGTGTGTGCACACTCATTCCTTCTGCTCTTGGGCACAGGCAGTGGGTGTAGAGGTAACC AGTAGCTTTGAGAAGCTACATGTAGCTCACCAGTGGTTTTCTCTAAGGAATCACAAAAGTAAACTACCCAACCACATGCCACGTAATATT TCAGCCATTCAGAGGAAACTGTTTTCTCTTTATTTGCTTATATGTTAATATGGTTTTTAAATTGGTAACTTTTATATAGTATGGTAACAG TATGTTAATACACACATACATACGCACACATGCTTTGGGTCCTTCCATAATACTTTTATATTTGTAAATCAATGTTTTGGAGCAATCCCA AGTTTAAGGGAAATATTTTTGTAAATGTAATGGTTTTGAAAATCTGAGCAATCCTTTTGCTTATACATTTTTAAAGCATTTGTGCTTTAA AATTGTTATGCTGGTGTTTGAAACATGATACTCCTGTGGTGCAGATGAGAAGCTATAACAGTGAATATGTGGTTTCTCTTACGTCATCCA CCTTGACATGATGGGTCAGAAACAAATGGAAATCCAGAGCAAGTCCTCCAGGGTTGCACCAGGTTTACCTAAAGCTTGTTGCCTTTTCTT GTGCTGTTTATGCGTGTAGAGCACTCAAGAAAGTTCTGAAACTGCTTTGTATCTGCTTTGTACTGTTGGTGCCTTCTTGGTATTGTACCC CAAAATTCTGCATAGATTATTTAGTATAATGGTAAGTTAAAAAATGTTAAAGGAAGATTTTATTAAGAATCTGAATGTTTATTCATTATA TTGTTACAATTTAACATTAACATTTATTTGTGGTATTTGTGATTTGGTTAATCTGTATAAAAATTGTAAGTAGAAAGGTTTATATTTCAT CTTAATTCTTTTGATGTTGTAAACGTACTTTTTAAAAGATGGATTATTTGAATGTTTATGGCACCTGACTTGTAAAAAAAAAAAACTACA AAAAAATCCTTAGAATCATTAAATTGTGTCCCTGTATTACCAAAATAACACAGCACCGTGCATGTATAGTTTAATTGCAGTTTCATCTGT GAAAACGTGAAATTGTCTAGTCCTTCGTTATGTTCCCCAGATGTCTTCCAGATTTGCTCTGCATGTGGTAACTTGTGTTAGGGCTGTGAG CTGTTCCTCGAGTTGAATGGGGATGTCAGTGCTCCTAGGGTTCTCCAGGTGGTTCTTCAGACCTTCACCTGTGGGGGGGGGGGTAGGCGG TGCCCACGCCCATCTCCTCATCCTCCTGAACTTCTGCAACCCCACTGCTGGGCAGACATCCTGGGCAACCCCTTTTTTCAGAGCAAGAAG TCATAAAGATAGGATTTCTTGGACATTTGGTTCTTATCAATATTGGGCATTATGTAATGACTTATTTACAAAACAAAGATACTGGAAAAT GTTTTGGATGTGGTGTTATGGAAAGAGCACAGGCCTTGGACCCATCCAGCTGGGTTCAGAACTACCCCCTGCTTATAACTGCGGCTGGCT GTGGGCCAGTCATTCTGCGTCTCTGCTTTCTTCCTCTGCTTCAGACTGTCAGCTGTAAAGTGGAAGCAATATTACTTGCCTTGTATATGG TAAAGATTATAAAAATACATTTCAACTGTTCAGCATAGTACTTCAAAGCAAGTACTCAGTAAATAGCAAGTCTTTTTAAATGCTGCTTTA TTTCACTAAATTTTGTTGTGAGGTGTCACTAAAATGCCTGCAAACAAACGTAACTGCTAATCTGAGAGGAAACCCTCTTACTAATCAGAG AAGAAACCCTCCTGTCAGAAACCTTCAGGGAAGTGAGCTGATCACACCTAAACTGGGAGTTTGCAATGGGGTATTTGAAGCACTGTGGGA GTATTCCACTGGCCCTCTCCCTGAGAGACTTAACAGTCTTCCCTGTTGTCCAGATTCTGTATAAGGCAATCAGAATAATCATCTTCCTTG TTCAGCAGAGGAGCCTGGTCCCATTTTCCCCACTTTGTGATGGGCTTCTCTCAGCGGTAGCTCAGCAGTTCCAGATGGCAGTTTGGACCA GCATCTAGGCTGGCCAGTTCGCTGTGTTTACTTAGAACCAACACGTTCAGAGCTGGCCTGGACCATCTGAGGGGAACAGGAAACACCCCT AGGCTGTGGAAGCAAGTGCAGACCCCCACCCCCGGCCCTGAAGCCAAGGGGGCAGGGTTTGGGAGTGGCCAAAGAGAAGCAGTGCAGGGA TGGGTTTTCCTAGGGACAGGCTTAGCATTCCTGACTCTAGGAAGAAGGAGCAGTGAGGCGGAGAAACAGTGGAGGGGATGGTGGCATTGG GCCCCATGGGGCCGAGATGGACACAGGGCTCGTTCTCTTGAGTCTGGTGCCAAGGACAGCTGAAGACGACATCATTTTCAGGTGGAGAGG AGAGAGTGGAGGGAGATCATGCCCTGTGATGTGTCTTTTGCAGGTGAAGGTGGGAGACAAGGTCTCTGCTGACGATGAGGCAGAGCCACC GTGAAAGTTGTAATAGGAGGACTGCCCGCCGCTGGAAGGGCCTGCAGTGACGCTAGGACACCCTCTGCCTGCATGTCACGTTAGCTGGGC TGGGCGAAGTAGAAGACCAAGGGGAAGAGGTGCAGTGGGGAGACCAGGTGGGATGCAACCACAGGACCAGTGGAGGGGCTGTGGCACGTG GGCGGAGACTGAGTGGCTGGGCATGTGTTGTGGCTGAGCATGTGGTGTGGGCAGTGGTCCTAGACCCCGCCATGTCCGGACAATGATATA GAGCGTCTCAGCATCGCCAGTCTAGACTGTCTATGGAGAGCAGAAAGTTGTCTGGGGCTGCCTGGGGAACTGTGAGGCCAGCTATATCAC CGTCGCTGATGGTGACATTACGGTGGTGGCAGGAGCAAGGAGAGAGGGAAGAAGGACCCCGTCCAGCTTTAGTCACAAAATACCCAATGG AAGATGCCAGTGCCAATCCTGTGGGTTTCCTTGGGACTTCACACTGGCTTTCTTATCTGCTCCAGATCCATTCAGTAGTCACTGAGTTCC TGCCAAATACTTTGTAGCGCCAGAAGCCAGGAGCGGGGTCTGCAGCAGGGCAGTCCCCATTTTCAGGAAATGCCTGGAGCTGCTGGTCCC TGAGAGAAAGGAAAACATCTTTCAGCCGTACGCAGGCCAAGAAGGCCAATGTCCAGTAGCTTTGTGATTTTTTTTATATTTTTTTATTTA TTTATTTTTGAGATAGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCAGTGGCGTGATCTCCACTCACTGCAACTTCCGCCTCCTGGGGTC AAGCAGTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACACGCCACCACACCCAGCTAATTTTTGTGTTTTTAGTAGAGACGGT TTCACCATGTCGGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGATTCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCA CCCAGCCTGTGATGTTTCTGTGGGGTTCCACAAATGTGTGTGTGTGTAAAAGCTGATGATTACAGCAAGAATGTGAACAGTAGCAGTTTT CCATTTGAAGGCAAGTTTTGTCTTTATCTGGGTATCAGAAGGACCCTCTGGGCCATTGTCGCTTCCTGTACTCAGAGCCACCCTAGTACT ACGGGCACACACAGAAAACAGCAGCCTGCGTACTTTCAAAGGAAAGGCATCTTTAATCACCAATGCCTGGAAAAATTATTTTGTTTCCCT CTTCCTTCCGTCTTGTTTCCTAACTTCTTACCAAAGTTTAGAGTCTGAGTTTTTCGTATAATAATGTCCCACATCCACACATCGGGCCTA CAGATGCTCTCCCTTGAATCGACTGGAAACATGACACCGGTTCCATGCTCTGGAACTGTCACCTGTGATGTGCTGGGCTGTGTCCCAAGC ACAGGAATCCCAGCAGTTTCAGCTCGATGCAGAACCACCATGCTCCAGACACAGGCTTGGGAAAGACACGTCAAAATTAAAATACTAGGT AAGAGAAGCACCTGATTGGGTAGAAGTTGGAGAGGAATCCTGGAATTTTGTGGCCAGAAGGAGCCACTGCCCCTTTTGTTTAGTAAGACT AGACAGTAACAGAAGCCAGTTGTCAGCTATGAAAGTGGTGGGTGAAGCAGGGGAGGCTCCTCTATGGTGGGACCCTGGACAAGGGAAGCC GAATGTGTGAAGAAGGGGTGCGGGGGTGTGCGGTGCCCTAGGACACTAGGGCAAAGGTTTCAAACCTGGAACAAGGCACTGGAGGAAGAT CTGCTGCCAGTCAGCAGTGCGGGCCCTCGAGTTAGCAGTCCGTGCGCAGAGGGGCCAGTTCTGAGACCAGTTTGGAGAGTCAGGCAGTGA CCCATTGGCCATGTCATAATTCCTTCAGCCTGCCTCCTCTTTAATCCCAGAGAGTGCTCTTTCTTCATACTTCCTTTAAAATACTAAATT GTTCCCATTCCATGGGGAGCTGGCTAGGCTTTACAGGCTAGGAAATGTAGGTTTTCTGAGATGGAACCATCTACACAAGGAGGAGGAAGG CACTAAGACTACAGATGAGACCCATGACAGGGCTGAGCATTTGGAAGCCAACCCTGGTTGCTTTTCAAGAATTGCTTTGTGGCTGGGTGC AGTGGTTCACACCTGTAATTGCAGCACTTTGGGAGGCTGAGGCAGGTGGATTGCTTGAACCCAGGAGTTCGAGACCAGCCTGGGCAACAT ATGGGACACCCCACCGCCCCCGGCTCTGCAAAAAAATTAAAAATTAGCCAGGCGTGGTGTCATGAGCCTGTGGTCTCAACTACTCAGGAG GCTGAGGCTGGAGGATCGCTTGAACCTGGGAGGTCAAGGCTCCAGTGAACCATAATTGTGCCACTGCACTGCAGCCTGGGCGACAATTTG TTTTCTAAATTGCTTTTGAAAGTCTACTGCATTACATATTCCAAAAAGCAGTGGTTTTCAAATACTTTTATCACCGATATCCTTTTATGA AATGAAATCAGTAGAACTTTCTCTGCTCTGAATAAGCAAGGGTGGGAACCTGTCTACCTCCCACAGATAGCATAATGTGCCTGCCATAGA GGAGCCAAAAAATGGTGATGGGAACTGAGAGGAGAGCAAATGTCACAAAAGACTGAGCAATTGAGAAAACAAAACAAGACCACAGATGAC TGTTAACGCCTCCACAGTGGACCAAGAAAGGACAGAGAGCTGGCAGCATGGGCATCACTGTCTGGTCGGCAGCAGGAAGGCCTCGCTAGG GAATTGAGTACAGTCATCTAACTAGTTTAAAAGTACAGGAAGGATGATTAAGGCTATTGGAGAGGTCATACAAATAGGGGAGGGGCAGGC AATGGCTGATAAGACATGAATTTGTAAGGCGATGAGTATTGCAGTCAGCAAAACAAACGAGACTGCTCTCCCAACACATAACTCAGCAGG GAGGCCAGGCATTGGTTTAACCATTTAATATAAAGAAGTTAAAATTACAAATGCGCTAAGTGCCTAAAGAAGAATAAGTGCAGGAATGAG AGCAGCATGGACTGCCACAGTTTTAGAATAAGCACTGTCACTGCTAGATTGGAAACAAAAATCCATAAATTTGGCCCGGTGTGGTGGCGG ACGCCTGTAGTCCCAGCTACTTGGAGGCTGAGGCGTGAGAATCGCTTGAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATGGCGCCAC TGCACTCCAGCCTGGGCGTCAGAGTGAGAACTCTGTATCAAAAAATAAAAATAAAAAAAAGTCCATAAATCTGCAATGTCTCAGTTAAGA AAGAAAGACTGGGCCAATGCAGATTTCAAACCGGAGAAAGTCATACTGTCAGTGAAGGCCGCCTGTGGCCGGAAGGCGCCAGGGGATTAG CACCCTGGACTCAGTGTTGCTGGGAAACAGGGCCCCAAGGCTGGGAGCACAGTGTTTAAAGGGCATCTACCCAAGAAGGGAGCACAGGGC AAGGAGGAGCTGCAGGGGGGCTTGGCTGCCAAAGTGAATTCTGAGGAGAGAGCTATTGCTGCCTACGATATGCAGGCTGCACAGAACACA AGTGGAATCAGCAGGCAGGAGAGGCAGCTAACGACGCAGCCCGTTTCTTATTTCTGTTTTCTCACAAGCGATGAAAGTGGAAAAGAGGGT GAGCAGGTGGCCCACACATGTGCCTCCAGTGCTGCGGCCCCTCCGGGGACCATCAGCCAGGCCCCGGGGAGGGAGCCAGCCACAGTGTGT CCGGCTCTTCTCTGAAGGGAAGAGAGCCTTGAATAGACTGAAGCGAAGACGGTTCTGCAAGGACAAGGCAGACCGAAGGCATTGGTTTTT TTTTTCAGATAAGGAGAATTAGACTCCCAAGTAGACACCAGAGTCACTGTTTGGTTGGTGGGTGATAGTGGGGTCACAGTGGCTGCCTGT GCTCCCCCAGGGTGAGCGTGACTGTGCTAACCTGGGTGGGGCAGCATGCACACCCCTCTGGCAGCCCTTTGTTGCTCGCTGATGACAAGT TTGGATGATCCCGCCAAACAGCTTGCTAAGATGTAGTCCCCAGTGTTGGAGGTGGGGCCTGATGGGAGGTGCTACCCTTGTGAGATAAGG TTGTGTAAAAGCCTGTGGCACCTCCCCACACTGACGCTCTCACCCCTGCTCTGGCCATGTGCCGCGCCTGCTCCCACTTCCCCTTCTGCC AGGAGTAAAAGCCCCCGAGACCTCCCAGAAGCCAAGCAGATGCTAGTGCCATGCTTCCTCTGCAGCCTGCAGAACTGTGAGCCAATTAAA >81611_81611_4_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000414786_MAPK1_chr22_22153417_ENST00000215832_length(amino acids)=309AA_BP=113 MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD -------------------------------------------------------------- >81611_81611_5_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000414786_MAPK1_chr22_22153417_ENST00000398822_length(transcript)=1321nt_BP=566nt ATGCAGCTGAGCCGCGCCGCCGCCGCCGCCGCCGCCGCCCCTGCGGAGCCCCCGGAGCCGCTGTCCCCCGCGCCGGCCCCGGCCCCGGCC CCCCCCGGCCCCCTCCCGCGCAGCGCGGCCGACGGGGCTCCGGCGGGGGGGAAGGGGGGGCCGGGGCGCCGCGCGCGGAGTCCCCGGGCG CTCCGTTCCCCGGCGCGAGCGGCCCCGGCCCGGGCCCCGGCGCGGGGATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCA TCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCGCCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACC ACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCCCGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGC AGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTTCGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATA AGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAG AATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCT GCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGAT CCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGGAACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGA ACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAAC AGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGG ATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACTGCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGTAC CTGGAGTTTAATACAGTGAGCTCTAGCAAGGGAGGCGCTGCCTTTTGTTTCTAGAATATTATGTTCCTCAAGGTCCATTATTTTGTATTC >81611_81611_5_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000414786_MAPK1_chr22_22153417_ENST00000398822_length(amino acids)=309AA_BP=113 MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD -------------------------------------------------------------- >81611_81611_6_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000414786_MAPK1_chr22_22153417_ENST00000544786_length(transcript)=1025nt_BP=566nt ATGCAGCTGAGCCGCGCCGCCGCCGCCGCCGCCGCCGCCCCTGCGGAGCCCCCGGAGCCGCTGTCCCCCGCGCCGGCCCCGGCCCCGGCC CCCCCCGGCCCCCTCCCGCGCAGCGCGGCCGACGGGGCTCCGGCGGGGGGGAAGGGGGGGCCGGGGCGCCGCGCGCGGAGTCCCCGGGCG CTCCGTTCCCCGGCGCGAGCGGCCCCGGCCCGGGCCCCGGCGCGGGGATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCA TCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCGCCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACC ACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCCCGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGC AGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTTCGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATA AGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCCCGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAG AATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAATTCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCT GCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAGCATTATCTTGACCAGCTGAACCACATTTTGGCTCTGGACTTAT TGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGA GTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAG >81611_81611_6_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000414786_MAPK1_chr22_22153417_ENST00000544786_length(amino acids)=266AA_BP=113 MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK -------------------------------------------------------------- >81611_81611_7_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000445220_MAPK1_chr22_22153417_ENST00000215832_length(transcript)=10680nt_BP=339nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT GCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGACAAGGGCTCAGAGGACTGGACGTGCTCAGACATCGGTGTTCTTCTTCCC AGTTCTTGACCCCTGGTCCTGTCTCCAGCCCGTCTTGGCTTATCCACTTTGACTCCTTTGAGCCGTTTGGAGGGGCGGTTTCTGGTAGTT GTGGCTTTTATGCTTTCAAAGAATTTCTTCAGTCCAGAGAATTCCTCCTGGCAGCCCTGTGTGTGTCACCCATTGGTGACCTGCGGCAGT ATGTACTTCAGTGCACCTACTGCTTACTGTTGCTTTAGTCACTAATTGCTTTCTGGTTTGAAAGATGCAGTGGTTCCTCCCTCTCCTGAA TCCTTTTCTACATGATGCCCTGCTGACCATGCAGCCGCACCAGAGAGAGATTCTTCCCCAATTGGCTCTAGTCACTGGCATCTCACTTTA TGATAGGGAAGGCTACTACCTAGGGCACTTTAAGTCAGTGACAGCCCCTTATTTGCACTTCACCTTTTGACCATAACTGTTTCCCCAGAG CAGGAGCTTGTGGAAATACCTTGGCTGATGTTGCAGCCTGCAGCAAGTGCTTCCGTCTCCGGAATCCTTGGGGAGCACTTGTCCACGTCT TTTCTCATATCATGGTAGTCACTAACATATATAAGGTATGTGCTATTGGCCCAGCTTTTAGAAAATGCAGTCATTTTTCTAAATAAAAAG GAAGTACTGCACCCAGCAGTGTCACTCTGTAGTTACTGTGGTCACTTGTACCATATAGAGGTGTAACACTTGTCAAGAAGCGTTATGTGC AGTACTTAATGTTTGTAAGACTTACAAAAAAAGATTTAAAGTGGCAGCTTCACTCGACATTTGGTGAGAGAAGTACAAAGGTTGCAGTGC TGAGCTGTGGGCGGTTTCTGGGGATGTCCCAGGGTGGAACTCCACATGCTGGTGCATATACGCCCTTGAGCTACTTCAAATGTGGGTGTT TCAGTAACCACGTTCCATGCCTGAGGATTTAGCAGAGAGGAACACTGCGTCTTTAAATGAGAAAGTATACAATTCTTTTTCCTTCTACAG CATGTCAGCATCTCAAGTTCATTTTTCAACCTACAGTATAACAATTTGTAATAAAGCCTCCAGGAGCTCATGACGTGAAGCACTGTTCTG TCCTCAAGTACTCAAATATTTCTGATACTGCTGAGTCAGACTGTCAGAAAAAGCTAGCACTAACTCGTGTTTGGAGCTCTATCCATATTT TACTGATCTCTTTAAGTATTTGTTCCTGCCACTGTGTACTGTGGAGTTGACTCGGTGTTCTGTCCCAGTGCGGTGCCTCCTCTTGACTTC CCCACTGCTCTCTGTGGTGAGAAATTTGCCTTGTTCAATAATTACTGTACCCTCGCATGACTGTTACAGCTTTCTGTGCAGAGATGACTG TCCAAGTGCCACATGCCTACGATTGAAATGAAAACTCTATTGTTACCTCTGAGTTGTGTTCCACGGAAAATGCTATCCAGCAGATCATTT AGGAAAAATAATTCTATTTTTAGCTTTTCATTTCTCAGCTGTCCTTTTTTCTTGTTTGATTTTTGACAGCAATGGAGAATGGGTTATATA AAGACTGCCTGCTAATATGAACAGAAATGCATTTGTAATTCATGAAAATAAATGTACATCTTCTATCTTCACATTCATGTTAAGATTCAG TGTTGCTTTCCTCTGGATCAGCGTGTCTGAATGGACAGTCAGGTTCAGGTTGTGCTGAACACAGAAATGCTCACAGGCCTCACTTTGCCG CCCAGGCACTGGCCCAGCACTTGGATTTACATAAGATGAGTTAGAAAGGTACTTCTGTAGGGTCCTTTTTACCTCTGCTCGGCAGAGAAT CGATGCTGTCATGTTCCTTTATTCACAATCTTAGGTCTCAAATATTCTGTCAAACCCTAACAAAGAAGCCCCGACATCTCAGGTTGGATT CCCTGGTTCTCTCTAAAGAGGGCCTGCCCTTGTGCCCCAGAGGTGCTGCTGGGCACAGCCAAGAGTTGGGAAGGGCCGCCCCACAGTACG CAGTCCTCACCACCCAGCCCAGGGTGCTCACGCTCACCACTCCTGTGGCTGAGGAAGGATAGCTGGCTCATCCTCGGAAAACAGACCCAC ATCTCTATTCTTGCCCTGAAATACGCGCTTTTCACTTGCGTGCTCAGAGCTGCCGTCTGAAGGTCCACACAGCATTGACGGGACACAGAA ATGTGACTGTTACCGGATAACACTGATTAGTCAGTTTTCATTTATAAAAAAGCATTGACAGTTTTATTACTCTTGTTTCTTTTTAAATGG AAAGTTACTATTATAAGGTTAATTTGGAGTCCTCTTCTAAATAGAAAACCATATCCTTGGCTACTAACATCTGGAGACTGTGAGCTCCTT CCCATTCCCCTTCCTGGTACTGTGGAGTCAGATTGGCATGAAACCACTAACTTCATTCTAGAATCATTGTAGCCATAAGTTGTGTGCTTT TTATTAATCATGCCAAACATAATGTAACTGGGCAGAGAATGGTCCTAACCAAGGTACCTATGAAAAGCGCTAGCTATCATGTGTAGTAGA TGCATCATTTTGGCTCTTCTTACATTTGTAAAAATGTACAGATTAGGTCATCTTAATTCATATTAGTGACACGGAACAGCACCTCCACTA TTTGTATGTTCAAATAAGCTTTCAGACTAATAGCTTTTTTGGTGTCTAAAATGTAAGCAAAAAATTCCTGCTGAAACATTCCAGTCCTTT CATTTAGTATAAAAGAAATACTGAACAAGCCAGTGGGATGGAATTGAAAGAACTAATCATGAGGACTCTGTCCTGACACAGGTCCTCAAA GCTAGCAGAGATACGCAGACATTGTGGCATCTGGGTAGAAGAATACTGTATTGTGTGTGCAGTGCACAGTGTGTGGTGTGTGCACACTCA TTCCTTCTGCTCTTGGGCACAGGCAGTGGGTGTAGAGGTAACCAGTAGCTTTGAGAAGCTACATGTAGCTCACCAGTGGTTTTCTCTAAG GAATCACAAAAGTAAACTACCCAACCACATGCCACGTAATATTTCAGCCATTCAGAGGAAACTGTTTTCTCTTTATTTGCTTATATGTTA ATATGGTTTTTAAATTGGTAACTTTTATATAGTATGGTAACAGTATGTTAATACACACATACATACGCACACATGCTTTGGGTCCTTCCA TAATACTTTTATATTTGTAAATCAATGTTTTGGAGCAATCCCAAGTTTAAGGGAAATATTTTTGTAAATGTAATGGTTTTGAAAATCTGA GCAATCCTTTTGCTTATACATTTTTAAAGCATTTGTGCTTTAAAATTGTTATGCTGGTGTTTGAAACATGATACTCCTGTGGTGCAGATG AGAAGCTATAACAGTGAATATGTGGTTTCTCTTACGTCATCCACCTTGACATGATGGGTCAGAAACAAATGGAAATCCAGAGCAAGTCCT CCAGGGTTGCACCAGGTTTACCTAAAGCTTGTTGCCTTTTCTTGTGCTGTTTATGCGTGTAGAGCACTCAAGAAAGTTCTGAAACTGCTT TGTATCTGCTTTGTACTGTTGGTGCCTTCTTGGTATTGTACCCCAAAATTCTGCATAGATTATTTAGTATAATGGTAAGTTAAAAAATGT TAAAGGAAGATTTTATTAAGAATCTGAATGTTTATTCATTATATTGTTACAATTTAACATTAACATTTATTTGTGGTATTTGTGATTTGG TTAATCTGTATAAAAATTGTAAGTAGAAAGGTTTATATTTCATCTTAATTCTTTTGATGTTGTAAACGTACTTTTTAAAAGATGGATTAT TTGAATGTTTATGGCACCTGACTTGTAAAAAAAAAAAACTACAAAAAAATCCTTAGAATCATTAAATTGTGTCCCTGTATTACCAAAATA ACACAGCACCGTGCATGTATAGTTTAATTGCAGTTTCATCTGTGAAAACGTGAAATTGTCTAGTCCTTCGTTATGTTCCCCAGATGTCTT CCAGATTTGCTCTGCATGTGGTAACTTGTGTTAGGGCTGTGAGCTGTTCCTCGAGTTGAATGGGGATGTCAGTGCTCCTAGGGTTCTCCA GGTGGTTCTTCAGACCTTCACCTGTGGGGGGGGGGGTAGGCGGTGCCCACGCCCATCTCCTCATCCTCCTGAACTTCTGCAACCCCACTG CTGGGCAGACATCCTGGGCAACCCCTTTTTTCAGAGCAAGAAGTCATAAAGATAGGATTTCTTGGACATTTGGTTCTTATCAATATTGGG CATTATGTAATGACTTATTTACAAAACAAAGATACTGGAAAATGTTTTGGATGTGGTGTTATGGAAAGAGCACAGGCCTTGGACCCATCC AGCTGGGTTCAGAACTACCCCCTGCTTATAACTGCGGCTGGCTGTGGGCCAGTCATTCTGCGTCTCTGCTTTCTTCCTCTGCTTCAGACT GTCAGCTGTAAAGTGGAAGCAATATTACTTGCCTTGTATATGGTAAAGATTATAAAAATACATTTCAACTGTTCAGCATAGTACTTCAAA GCAAGTACTCAGTAAATAGCAAGTCTTTTTAAATGCTGCTTTATTTCACTAAATTTTGTTGTGAGGTGTCACTAAAATGCCTGCAAACAA ACGTAACTGCTAATCTGAGAGGAAACCCTCTTACTAATCAGAGAAGAAACCCTCCTGTCAGAAACCTTCAGGGAAGTGAGCTGATCACAC CTAAACTGGGAGTTTGCAATGGGGTATTTGAAGCACTGTGGGAGTATTCCACTGGCCCTCTCCCTGAGAGACTTAACAGTCTTCCCTGTT GTCCAGATTCTGTATAAGGCAATCAGAATAATCATCTTCCTTGTTCAGCAGAGGAGCCTGGTCCCATTTTCCCCACTTTGTGATGGGCTT CTCTCAGCGGTAGCTCAGCAGTTCCAGATGGCAGTTTGGACCAGCATCTAGGCTGGCCAGTTCGCTGTGTTTACTTAGAACCAACACGTT CAGAGCTGGCCTGGACCATCTGAGGGGAACAGGAAACACCCCTAGGCTGTGGAAGCAAGTGCAGACCCCCACCCCCGGCCCTGAAGCCAA GGGGGCAGGGTTTGGGAGTGGCCAAAGAGAAGCAGTGCAGGGATGGGTTTTCCTAGGGACAGGCTTAGCATTCCTGACTCTAGGAAGAAG GAGCAGTGAGGCGGAGAAACAGTGGAGGGGATGGTGGCATTGGGCCCCATGGGGCCGAGATGGACACAGGGCTCGTTCTCTTGAGTCTGG TGCCAAGGACAGCTGAAGACGACATCATTTTCAGGTGGAGAGGAGAGAGTGGAGGGAGATCATGCCCTGTGATGTGTCTTTTGCAGGTGA AGGTGGGAGACAAGGTCTCTGCTGACGATGAGGCAGAGCCACCGTGAAAGTTGTAATAGGAGGACTGCCCGCCGCTGGAAGGGCCTGCAG TGACGCTAGGACACCCTCTGCCTGCATGTCACGTTAGCTGGGCTGGGCGAAGTAGAAGACCAAGGGGAAGAGGTGCAGTGGGGAGACCAG GTGGGATGCAACCACAGGACCAGTGGAGGGGCTGTGGCACGTGGGCGGAGACTGAGTGGCTGGGCATGTGTTGTGGCTGAGCATGTGGTG TGGGCAGTGGTCCTAGACCCCGCCATGTCCGGACAATGATATAGAGCGTCTCAGCATCGCCAGTCTAGACTGTCTATGGAGAGCAGAAAG TTGTCTGGGGCTGCCTGGGGAACTGTGAGGCCAGCTATATCACCGTCGCTGATGGTGACATTACGGTGGTGGCAGGAGCAAGGAGAGAGG GAAGAAGGACCCCGTCCAGCTTTAGTCACAAAATACCCAATGGAAGATGCCAGTGCCAATCCTGTGGGTTTCCTTGGGACTTCACACTGG CTTTCTTATCTGCTCCAGATCCATTCAGTAGTCACTGAGTTCCTGCCAAATACTTTGTAGCGCCAGAAGCCAGGAGCGGGGTCTGCAGCA GGGCAGTCCCCATTTTCAGGAAATGCCTGGAGCTGCTGGTCCCTGAGAGAAAGGAAAACATCTTTCAGCCGTACGCAGGCCAAGAAGGCC AATGTCCAGTAGCTTTGTGATTTTTTTTATATTTTTTTATTTATTTATTTTTGAGATAGAGTCTTGCTCTGTCGCTCAGGCTGGAGTGCA GTGGCGTGATCTCCACTCACTGCAACTTCCGCCTCCTGGGGTCAAGCAGTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGCACAC GCCACCACACCCAGCTAATTTTTGTGTTTTTAGTAGAGACGGTTTCACCATGTCGGCCAGGCTGGTCTCAAACTCCTGACCTCAGATGAT TCAGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCCAGCCTGTGATGTTTCTGTGGGGTTCCACAAATGTGTGTGTGTGT AAAAGCTGATGATTACAGCAAGAATGTGAACAGTAGCAGTTTTCCATTTGAAGGCAAGTTTTGTCTTTATCTGGGTATCAGAAGGACCCT CTGGGCCATTGTCGCTTCCTGTACTCAGAGCCACCCTAGTACTACGGGCACACACAGAAAACAGCAGCCTGCGTACTTTCAAAGGAAAGG CATCTTTAATCACCAATGCCTGGAAAAATTATTTTGTTTCCCTCTTCCTTCCGTCTTGTTTCCTAACTTCTTACCAAAGTTTAGAGTCTG AGTTTTTCGTATAATAATGTCCCACATCCACACATCGGGCCTACAGATGCTCTCCCTTGAATCGACTGGAAACATGACACCGGTTCCATG CTCTGGAACTGTCACCTGTGATGTGCTGGGCTGTGTCCCAAGCACAGGAATCCCAGCAGTTTCAGCTCGATGCAGAACCACCATGCTCCA GACACAGGCTTGGGAAAGACACGTCAAAATTAAAATACTAGGTAAGAGAAGCACCTGATTGGGTAGAAGTTGGAGAGGAATCCTGGAATT TTGTGGCCAGAAGGAGCCACTGCCCCTTTTGTTTAGTAAGACTAGACAGTAACAGAAGCCAGTTGTCAGCTATGAAAGTGGTGGGTGAAG CAGGGGAGGCTCCTCTATGGTGGGACCCTGGACAAGGGAAGCCGAATGTGTGAAGAAGGGGTGCGGGGGTGTGCGGTGCCCTAGGACACT AGGGCAAAGGTTTCAAACCTGGAACAAGGCACTGGAGGAAGATCTGCTGCCAGTCAGCAGTGCGGGCCCTCGAGTTAGCAGTCCGTGCGC AGAGGGGCCAGTTCTGAGACCAGTTTGGAGAGTCAGGCAGTGACCCATTGGCCATGTCATAATTCCTTCAGCCTGCCTCCTCTTTAATCC CAGAGAGTGCTCTTTCTTCATACTTCCTTTAAAATACTAAATTGTTCCCATTCCATGGGGAGCTGGCTAGGCTTTACAGGCTAGGAAATG TAGGTTTTCTGAGATGGAACCATCTACACAAGGAGGAGGAAGGCACTAAGACTACAGATGAGACCCATGACAGGGCTGAGCATTTGGAAG CCAACCCTGGTTGCTTTTCAAGAATTGCTTTGTGGCTGGGTGCAGTGGTTCACACCTGTAATTGCAGCACTTTGGGAGGCTGAGGCAGGT GGATTGCTTGAACCCAGGAGTTCGAGACCAGCCTGGGCAACATATGGGACACCCCACCGCCCCCGGCTCTGCAAAAAAATTAAAAATTAG CCAGGCGTGGTGTCATGAGCCTGTGGTCTCAACTACTCAGGAGGCTGAGGCTGGAGGATCGCTTGAACCTGGGAGGTCAAGGCTCCAGTG AACCATAATTGTGCCACTGCACTGCAGCCTGGGCGACAATTTGTTTTCTAAATTGCTTTTGAAAGTCTACTGCATTACATATTCCAAAAA GCAGTGGTTTTCAAATACTTTTATCACCGATATCCTTTTATGAAATGAAATCAGTAGAACTTTCTCTGCTCTGAATAAGCAAGGGTGGGA ACCTGTCTACCTCCCACAGATAGCATAATGTGCCTGCCATAGAGGAGCCAAAAAATGGTGATGGGAACTGAGAGGAGAGCAAATGTCACA AAAGACTGAGCAATTGAGAAAACAAAACAAGACCACAGATGACTGTTAACGCCTCCACAGTGGACCAAGAAAGGACAGAGAGCTGGCAGC ATGGGCATCACTGTCTGGTCGGCAGCAGGAAGGCCTCGCTAGGGAATTGAGTACAGTCATCTAACTAGTTTAAAAGTACAGGAAGGATGA TTAAGGCTATTGGAGAGGTCATACAAATAGGGGAGGGGCAGGCAATGGCTGATAAGACATGAATTTGTAAGGCGATGAGTATTGCAGTCA GCAAAACAAACGAGACTGCTCTCCCAACACATAACTCAGCAGGGAGGCCAGGCATTGGTTTAACCATTTAATATAAAGAAGTTAAAATTA CAAATGCGCTAAGTGCCTAAAGAAGAATAAGTGCAGGAATGAGAGCAGCATGGACTGCCACAGTTTTAGAATAAGCACTGTCACTGCTAG ATTGGAAACAAAAATCCATAAATTTGGCCCGGTGTGGTGGCGGACGCCTGTAGTCCCAGCTACTTGGAGGCTGAGGCGTGAGAATCGCTT GAACCCGGGAGGCGGAGGTTGCAGTGAGCCGAGATGGCGCCACTGCACTCCAGCCTGGGCGTCAGAGTGAGAACTCTGTATCAAAAAATA AAAATAAAAAAAAGTCCATAAATCTGCAATGTCTCAGTTAAGAAAGAAAGACTGGGCCAATGCAGATTTCAAACCGGAGAAAGTCATACT GTCAGTGAAGGCCGCCTGTGGCCGGAAGGCGCCAGGGGATTAGCACCCTGGACTCAGTGTTGCTGGGAAACAGGGCCCCAAGGCTGGGAG CACAGTGTTTAAAGGGCATCTACCCAAGAAGGGAGCACAGGGCAAGGAGGAGCTGCAGGGGGGCTTGGCTGCCAAAGTGAATTCTGAGGA GAGAGCTATTGCTGCCTACGATATGCAGGCTGCACAGAACACAAGTGGAATCAGCAGGCAGGAGAGGCAGCTAACGACGCAGCCCGTTTC TTATTTCTGTTTTCTCACAAGCGATGAAAGTGGAAAAGAGGGTGAGCAGGTGGCCCACACATGTGCCTCCAGTGCTGCGGCCCCTCCGGG GACCATCAGCCAGGCCCCGGGGAGGGAGCCAGCCACAGTGTGTCCGGCTCTTCTCTGAAGGGAAGAGAGCCTTGAATAGACTGAAGCGAA GACGGTTCTGCAAGGACAAGGCAGACCGAAGGCATTGGTTTTTTTTTTCAGATAAGGAGAATTAGACTCCCAAGTAGACACCAGAGTCAC TGTTTGGTTGGTGGGTGATAGTGGGGTCACAGTGGCTGCCTGTGCTCCCCCAGGGTGAGCGTGACTGTGCTAACCTGGGTGGGGCAGCAT GCACACCCCTCTGGCAGCCCTTTGTTGCTCGCTGATGACAAGTTTGGATGATCCCGCCAAACAGCTTGCTAAGATGTAGTCCCCAGTGTT GGAGGTGGGGCCTGATGGGAGGTGCTACCCTTGTGAGATAAGGTTGTGTAAAAGCCTGTGGCACCTCCCCACACTGACGCTCTCACCCCT GCTCTGGCCATGTGCCGCGCCTGCTCCCACTTCCCCTTCTGCCAGGAGTAAAAGCCCCCGAGACCTCCCAGAAGCCAAGCAGATGCTAGT >81611_81611_7_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000445220_MAPK1_chr22_22153417_ENST00000215832_length(amino acids)=309AA_BP=113 MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD -------------------------------------------------------------- >81611_81611_8_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000445220_MAPK1_chr22_22153417_ENST00000398822_length(transcript)=1094nt_BP=339nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGGTATTCTTGGATCCCCATCACAAGAAGACCTGAATTGTATAATAAATTTAAAAGCTAGG AACTATTTGCTTTCTCTTCCACACAAAAATAAGGTGCCATGGAACAGGCTGTTCCCAAATGCTGACTCCAAAGCTCTGGACTTATTGGAC AAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAACAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGAC GAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTGGATGACTTGCCTAAGGAAAAGCTCAAAGAACTAATTTTTGAAGAGACT GCTAGATTCCAGCCAGGATACAGATCTTAAATTTGTCAGGTACCTGGAGTTTAATACAGTGAGCTCTAGCAAGGGAGGCGCTGCCTTTTG TTTCTAGAATATTATGTTCCTCAAGGTCCATTATTTTGTATTCTTTTCCAAGCTCCTTATTGGAAGGTATTTTTTTAAATTTAGAATTAA >81611_81611_8_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000445220_MAPK1_chr22_22153417_ENST00000398822_length(amino acids)=309AA_BP=113 MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK HYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSD -------------------------------------------------------------- >81611_81611_9_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000445220_MAPK1_chr22_22153417_ENST00000544786_length(transcript)=798nt_BP=339nt ATGGACGGCCCCGGGGCCAGCGCCGTGGTCGTGCGCGTCGGCATCCCGGACCTGCAGCAGACGAAGTGCCTGCGCCTGGACCCGGCCGCG CCCGTGTGGGCCGCCAAGCAGCGCGTGCTCTGCGCCCTCAACCACAGCCTCCAGGACGCGCTCAACTATGGGCTTTTCCAGCCGCCCTCC CGGGGCCGCGCCGGCAAGTTCCTGGATGAGGAGCGGCTCCTGCAGGAGTACCCGCCCAACCTGGACACGCCCCTGCCCTACCTGGAGTTT CGATACAAGCGGCGAGTTTATGCCCAGAACCTCATCGATGATAAGCAGTTTGCAAAGCTTCACACAAAGATCTGTGACTTTGGCCTGGCC CGTGTTGCAGATCCAGACCATGATCACACAGGGTTCCTGACAGAATATGTGGCCACACGTTGGTACAGGGCTCCAGAAATTATGTTGAAT TCCAAGGGCTACACCAAGTCCATTGATATTTGGTCTGTAGGCTGCATTCTGGCAGAAATGCTTTCTAACAGGCCCATCTTTCCAGGGAAG CATTATCTTGACCAGCTGAACCACATTTTGGCTCTGGACTTATTGGACAAAATGTTGACATTCAACCCACACAAGAGGATTGAAGTAGAA CAGGCTCTGGCCCACCCATATCTGGAGCAGTATTACGACCCGAGTGACGAGCCCATCGCCGAAGCACCATTCAAGTTCGACATGGAATTG >81611_81611_9_SHANK3-MAPK1_SHANK3_chr22_51115121_ENST00000445220_MAPK1_chr22_22153417_ENST00000544786_length(amino acids)=265AA_BP=113 MDGPGASAVVVRVGIPDLQQTKCLRLDPAAPVWAAKQRVLCALNHSLQDALNYGLFQPPSRGRAGKFLDEERLLQEYPPNLDTPLPYLEF RYKRRVYAQNLIDDKQFAKLHTKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for SHANK3-MAPK1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for SHANK3-MAPK1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SHANK3-MAPK1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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