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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SHB-PALM2-AKAP2 (FusionGDB2 ID:81627)

Fusion Gene Summary for SHB-PALM2-AKAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: SHB-PALM2-AKAP2
Fusion gene ID: 81627
HgeneTgene
Gene symbol

SHB

PALM2-AKAP2

Gene ID

6461

445815

Gene nameSH2 domain containing adaptor protein BPALM2 and AKAP2 fusion
SynonymsbA3J10.2AKAP-2|AKAP-KL|AKAP2|AKAPKL|MISP2|PALM2|PALM2-AKAP2|PRKA2
Cytomap

9p13.1

9q31.3

Type of geneprotein-codingprotein-coding
DescriptionSH2 domain-containing adapter protein BSHB (Src homology 2 domain containing) adaptor protein BSHB adaptor protein (a Src homology 2 protein)Src homology 2 domain containing adaptor protein BA-kinase anchor protein 2PALM2-AKAP2 proteinparalemmin-2A kinase (PRKA) anchor protein 2A-kinase anchoring protein 2PALM2-AKAP2 fusionPALM2-AKAP2 readthroughparalemmin 2protein kinase A anchoring protein 2protein kinase A2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000377700, ENST00000377707, 
ENST00000302798, ENST00000374530, 
Fusion gene scores* DoF score15 X 10 X 8=120018 X 17 X 5=1530
# samples 1919
** MAII scorelog2(19/1200*10)=-2.65896308216493
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(19/1530*10)=-3.00946032924907
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SHB [Title/Abstract] AND PALM2-AKAP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSHB(38067926)-PALM2-AKAP2(112629771), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SHB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PALM2-AKAP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A06Z-01ASHBchr9

38067926

-PALM2-AKAP2chr9

112629771

+


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Fusion Gene ORF analysis for SHB-PALM2-AKAP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000377700ENST00000302798SHBchr9

38067926

-PALM2-AKAP2chr9

112629771

+
In-frameENST00000377700ENST00000374530SHBchr9

38067926

-PALM2-AKAP2chr9

112629771

+
In-frameENST00000377707ENST00000302798SHBchr9

38067926

-PALM2-AKAP2chr9

112629771

+
In-frameENST00000377707ENST00000374530SHBchr9

38067926

-PALM2-AKAP2chr9

112629771

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000377707SHBchr938067926-ENST00000374530PALM2-AKAP2chr9112629771+8565128350045491349
ENST00000377707SHBchr938067926-ENST00000302798PALM2-AKAP2chr9112629771+5923128350045101336
ENST00000377700SHBchr938067926-ENST00000374530PALM2-AKAP2chr9112629771+8567128550245511349
ENST00000377700SHBchr938067926-ENST00000302798PALM2-AKAP2chr9112629771+5925128550245121336

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000377707ENST00000374530SHBchr938067926-PALM2-AKAP2chr9112629771+0.0011367670.9988632
ENST00000377707ENST00000302798SHBchr938067926-PALM2-AKAP2chr9112629771+0.0048391940.99516076
ENST00000377700ENST00000374530SHBchr938067926-PALM2-AKAP2chr9112629771+0.0011377970.99886227
ENST00000377700ENST00000302798SHBchr938067926-PALM2-AKAP2chr9112629771+0.0048334090.99516666

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Fusion Genomic Features for SHB-PALM2-AKAP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SHBchr938067925-PALM2-AKAP2chr9112629770+7.69E-060.99999225
SHBchr938067925-PALM2-AKAP2chr9112629770+7.69E-060.99999225

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SHB-PALM2-AKAP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:38067926/chr9:112629771)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSHBchr9:38067926chr9:112629771ENST00000377700-13410_504239298.0DomainSH2
HgeneSHBchr9:38067926chr9:112629771ENST00000377707-16410_504239510.0DomainSH2


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Fusion Gene Sequence for SHB-PALM2-AKAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81627_81627_1_SHB-PALM2-AKAP2_SHB_chr9_38067926_ENST00000377700_PALM2-AKAP2_chr9_112629771_ENST00000302798_length(transcript)=5925nt_BP=1285nt
GCGCCGCCGGGACGGGCACGGGCGCGCGGGCTCCGGCGGGCGCCGGCTGCCTTCCTCCGTCGCTCGCTGTCTCTCCCGGCCGCATTCTCC
TCCGCTGCGGGGCCGAGCTCTCCCCAGCGCTCGCAGGAAGGAAGAAGGGAGCCGAGGACGCCGAGAAGTTCCCGCGGCAGCCGCGGATCC
CGGCCAAGGCGGAGGCTGCGGCTCCGACGGGGCAGGAGCGCGATCCACGGCGAGGGGCGTACGGCCAAAGGGTCCGCGGCGTGGAGCGCT
CGGACCTTCCGCTCTCCCCCGGGCGTGGGCCGGGACCCCATGAGACGCGCCCACGAGGGGCGCGAGATTCCTAGCTTGGGCGGCGCTAGG
CGGAGGGAGGTGTTGCAGCCGCCGGAGCCAGAGAGCTGCCGGCAGGAGGCGGCGGCGGCAAGAACTTGAACTTGGCGTCGGGAGCGGGCG
CCCCGGACGCCCCCCGCCGGGGCCGGGGCGCCGAGGGACCTGCGCCGCAGCGCTGCCCCCCGAATGGCCGCGGCGGCGGACCGGGCTCCC
GCGCCGCGGCCCTAGGCGGCCTCTCGCCATGGCCAAGTGGCTAAACAAGTACTTCAGCTTGGGCAACAGCAAGACCAAGAGCCCCCCGCA
GCCGCCGCGGCCAGACTACCGCGAGCAGCGGCGCCGAGGCGAGCGGCCTTCGCAGCCCCCCCAGGCCGTGCCGCAGGCCTCCTCCGCCGC
CTCGGCGTCCTGCGGTCCGGCCACCGCCTCCTGCTTCTCAGCCTCTTCGGGCTCGCTGCCCGACGACAGCGGCAGCACCAGCGACCTCAT
CCGCGCCTACCGCGCGCAGAAGGAGCGAGACTTCGAGGACCCCTACAACGGGCCTGGCTCGTCGCTGCGCAAACTGCGCGCCATGTGCCG
CCTGGACTACTGCGGCGGCAGCGGGGAGCCAGGCGGGGTCCAGCGCGCCTTCTCGGCCTCGTCCGCGTCGGGCGCCGCGGGCTGTTGCTG
CGCCTCCTCGGGCGCGGGGGCCGCCGCGTCCTCGTCCTCGTCCTCCGGCTCTCCGCATCTCTACCGCAGCAGCAGCGAGCGGCGGCCCGC
CACGCCGGCCGAGGTGCGCTACATCTCCCCCAAGCACCGCCTCATCAAAGTGGAGAGCGCCGCGGGCGGTGGGGCCGGGGACCCCCTGGG
GGGCGCCTGCGCGGGCGGCCGCACCTGGAGCCCGACGGCCTGCGGAGGCAAGAAACTGCTCAACAAGTGCGCCGCCTCAGCCGCGGAGGA
GAGCGGGGCCGGCAAGAAGGACAAGGAAAAAAGAAAGAGGCAGACTGAAATAGAAGGCAAGCGACAACAGCTTGACGAGCAGATACTTCT
GCTGCAGCATTCCAAGTCCAAAGTGCTTCGGGAGAAATGGCTGCTGCAGGGCATACCCGCTGGAACTGCCGAAGAGGAGGAAGCCAGGAG
GCGGCAGTCTGAAGAGGATGAGTTCAGAGTCAAGCAACTTGAAGATAACATTCAGAGGCTGGAGCAAGAAATACAAACGCTAGAAAGTGA
AGAGTCCCAGATATCTGCCAAAGAGCAAATCATCCTAGAGAAACTGAAGGAAACAGAAAAATCCTTCAAGGACTTTCAGAAGGGTTTCTC
CAGTACGGATGGAGATGCAGTAAATTACATTTCCTCCCAGCTTCCCGACCTGCCAATCCTCTGTTCACGAACAGCAGAACCATCACCTGG
GCAGGACGGGACCAGCAGAGCGGCTGGAGTCGGGTGGGAGAATGTGCTGCTAAAGGAAGGTGAGTCAGCCTCGAACGCCACAGAAACATC
CGGCCCAGACATGACTATCAAGAAGCCTCCCCAGCTTTCTGAGGATGATATCTGGCTAAAAAGCGAGGGAGACAACTATAGTGCCACCCT
CCTGGAGCCTGCTGCCAGCTCTCTTTCCCCAGATCACAAAAACATGGAAATTGAGGTGTCTGTTGCAGAATGTAAAAGTGTTCCTGGAAT
CACCTCTACCCCACATCCCATGGACCATCCCTCCGCTTTCTATTCACCCCCGCATAATGGCCTCCTTACTGATCACCACGAATCCCTGGA
TAATGATGTTGCCAGAGAGATCCGCTATCTAGATGAGGTGCTAGAGGCCAACTGCTGTGATTCTGCTGTGGATGGAACGTACAATGGAAC
ATCCTCCCCAGAGCCTGGTGCAGTGGTTCTGGTGGGCGGCCTAAGCCCCCCTGTCCACGAGGCGACCCAGCCAGAACCCACTGAAAGAAC
AGCTAGCCGGCAGGCACCTCCTCACATCGAGCTCAGTAATAGCAGCCCTGACCCCATGGCAGAGGCAGAAAGAACAAATGGCCATTCCCC
CAGCCAGCCTAGAGATGCGCTGGGGGACAGCCTGCAGGTGCCTGTCAGCCCCAGCTCCACAACCAGCTCACGGTGTTCTTCCCGAGATGG
AGAGTTCACTCTCACCACACTGAAAAAGGAGGCCAAGTTTGAGCTGCGTGCCTTCCATGAGGACAAGAAGCCCTCCAAGCTCTTTGAGGA
TGACGAGCATGAGAAAGAACAATACTGCATTAGAAAAGTGAGGCCTTCAGAGGAGATGCTGGAGCTGGAAAAGGAGAGGAGAGAGCTCAT
CCGCAGCCAGGCCGTCAAGAAGAATCCTGGCATTGCAGCAAAATGGTGGAATCCCCCGCAGGAAAAAACCATCGAGGAGCAGCTGGACGA
GGAACATCTGGAGTCGCACAAAAAGTACAAGGAGCGCAAAGAGAGAAGGGCACAGCAGGAACAGTTGCTGCTGCAGAAGCAGTTACAGCA
GCAGCAGCAGCAGCCCCCATCGCAGCTCTGCACAGCCCCTGCCTCTTCTCATGAACGCGCAAGCATGATTGACAAAGCAAAGGAGGACAT
TGTCACAGAGCAGATAGATTTCTCTGCTGCTCGCAAACAATTTCAGCTGATGGAGAATTCCAGGCAAGCGGTGGCCAAGGGCCAGAGTAC
ACCCAGGCTGTTCTCCATCAAGCCTTTCTACAGGCCTCTGGGGTCAGTCAACTCAGACAAGCCACTGACTAATCCGAGACCACCTTCTGT
CGGGGGACCTCCAGAAGACAGTGGTGCCTCAGCCGCCAAGGGACAGAAATCCCCCGGTGCCCTGGAGACCCCATCGGCAGCAGGAAGCCA
GGGCAACACAGCCTCTCAGGGGAAGGAAGGGCCCTACAGCGAGCCTTCTAAACGTGGGCCCTTATCTAAACTGTGGGCTGAGGATGGAGA
ATTTACGAGCGCCCGGGCTGTCCTCACTGTGGTCAAGGATGATGACCATGGGATTTTGGATCAGTTCTCAAGATCTGTCAATGTCTCCTT
GACCCAAGAGGAGCTTGACTCTGGTCTGGACGAATTGTCGGTGAGGTCTCAGGATACCACAGTCCTGGAGACCCTATCCAATGATTTCAG
CATGGACAACATCAGTGACAGCGGGGCATCCAATGAGACAACCAATGCCCTCCAGGAAAATTCACTGGCTGATTTTTCTCTGCCCCAGAC
ACCACAAACTGACAACCCCTCAGAGGGCCGAGGAGAAGGCGTCTCCAAGTCATTTAGTGATCATGGTTTCTATTCCCCTTCCTCCACGCT
GGGGGACTCTCCGTTGGTTGATGACCCCTTGGAGTATCAGGCTGGCCTCCTGGTGCAGAATGCCATTCAACAAGCCATAGCCGAGCAGGT
GGATAAAGCTGTGTCCAAAACCAGCAGGGATGGAGCAGAGCAACAGGGACCTGAAGCGACTGTAGAGGAAGCTGAAGCTGCGGCTTTCGG
CTCAGAAAAGCCTCAGAGCATGTTTGAGCCACCTCAGGTGTCTTCTCCTGTTCAAGAGAAAAGGGATGTATTACCAAAGATTCTGCCTGC
TGAAGACAGGGCGCTCAGGGAAAGGGGGCCCCCCCAGCCACTGCCAGCTGTGCAGCCCAGTGGCCCGATTAACATGGAGGAGACCAGGCC
CGAAGGAAGCTATTTCAGCAAGTACTCGGAGGCAGCTGAGCTGAGAAGCACAGCCTCCCTCCTGGCCACTCAAGAATCTGACGTGATGGT
TGGGCCTTTCAAGCTGAGGTCCAGGAAACAGCGGACTTTGTCCATGATTGAGGAAGAGATCCGAGCAGCTCAGGAAAGGGAAGAGGAGCT
GAAGAGGCAGAGACAAGTCTTGCAGAGTACGCAGAGCCCCAGGACAAAGAATGCCCCATCACTGCCCTCCAGAACATGCTACAAAACTGC
TCCAGGGAAAATAGAGAAAGTCAAACCTCCTCCATCCCCCACCACTGAAGGCCCCAGCTTGCAGCCTGACTTAGCCCCTGAAGAGGCTGC
CGGAACCCAGCGGCCCAAGAATCTGATGCAGACCCTCATGGAAGACTATGAGACACACAAATCTAAAAGGCGCGAGAGAATGGATGATAG
TAGTGTCCTCGAGGCCACACGGGTTAATCGAAGAAAGAGCGCACTGGCTTTGCGCTGGGAAGCAGGGATCTATGCCAACCAGGAGGAAGA
AGACAACGAATAAACTTCCTTCAACCCAGGAAGCGTCTTTGGTGCTTGGGAGACCAAGAAACCAAGAAATTAACAACTGAAAGCATTTTA
ATGGACTATTTATTAAAGTGCAAACAAACTCAGCAATCCTTATGTAGACCAGAAGCTGCAATATACAATGATGAAAATGAAACGAAAAGG
AAGTCCCCCCATCAGACTCTGGACACCCAGGAATCAAAAGAGAAAGGACTTTTTTGGTGACTCAATCCCAGTGTCTGGTTTGGGGCCAAT
CTACAATGGATCCAAAAGGACAAAACATGTTACAAGCAAATCAACATAGTTGCTGCAGGCGGAACTGAGACCAGCCTCTCTGGGCGATGA
AGGACAATGGTGGTAGGGCCACTTAGAGAGCAGTAGGGCCCAGGCTGGTGCAGCCTACATGGCACAGGATATTTCCCTGCACCAGTTTCC
CACCTGTCACTTGCAGCATCAGAGGGTGTTGCATTAACTCCATTTTCTCCAGCAGCCATAAAATGAATGGCGTTTCTCTCCATATTTGCC
CAGAAGAGGCAGTTATGATTCCACTTCTCCTACATTTAATTATTTTTAATTGAGAACAACTCATGATCACAATTCATAAAATCCATATTT
TAAGACAATAGTTCTTCATGTCACAAACACAATCTATTCTACATGAGGAGGCTGAGAAAGGGGAAGAGAAAAACAAACCAAATGGATGAT
GTTAGCTTTAGGATCGTGTCTGCTTATAATATTCACTGATCTGCAGTTTATGAGAACACATTTTCACAGTTATGTTTCTTCATAGGAAAA
CTATATTTAGTGGGCAACAACTATTTTTATGATGGGATGGGGGAGTATATACACGTATAGAATCTGTACGCGTTGAACAACTTGGTTCAA
GATGGTGGGGGCATTTTTAGAGCGGCAATAATTGAAAAAAAAGGCGAACTCTGCCTTGGAGAGGTAGATGATAAGAAATAAAAAGGTGTT
TATAACTATTTTGTATTATAAAGTGGGCCTTAGAGATAGGAAGAAGAATGATGGATTCCTTTTGGATCAATCAGAAAGGAAACACGAAAG
AAAAGTCAGGAAGGTAGAGAGAGAAAAAGGGAGGGAAGGAGAAAGAATGGGAATAAAATAAGGAGGTAAGAGATACTATTTTTGCTGAGC
AACCAGTGTGTTTCAGGATGATACAAAGAAAAATATAGAATAGAAATAAGTGCAGGCTTGGAATCAGCTACAAATCCTAAAGATGGGGTG
TGTGTGGATGTGTGTGTGTGTGTGTGTACACCATTGTGTGTTTGTAAAATGTGTATGTTCATGAGTAAGGGTGTGTGTGTGTGTGTATTA

>81627_81627_1_SHB-PALM2-AKAP2_SHB_chr9_38067926_ENST00000377700_PALM2-AKAP2_chr9_112629771_ENST00000302798_length(amino acids)=1336AA_BP=260
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKEKRKRQTEI
EGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKE
TEKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAGVGWENVLLKEGESASNATETSGPDMTIKKPPQLSEDDI
WLKSEGDNYSATLLEPAASSLSPDHKNMEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVLEAN
CCDSAVDGTYNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVPVSP
SSTTSSRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAKWWN
PPQEKTIEEQLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKAKEDIVTEQIDFSAARKQFQLM
ENSRQAVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPRPPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSEPSK
RGPLSKLWAEDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETTNAL
QENSLADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSPSSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGP
EATVEEAEAAAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINMEETRPEGSYFSKYSEAAELRST
ASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEG

--------------------------------------------------------------
>81627_81627_2_SHB-PALM2-AKAP2_SHB_chr9_38067926_ENST00000377700_PALM2-AKAP2_chr9_112629771_ENST00000374530_length(transcript)=8567nt_BP=1285nt
GCGCCGCCGGGACGGGCACGGGCGCGCGGGCTCCGGCGGGCGCCGGCTGCCTTCCTCCGTCGCTCGCTGTCTCTCCCGGCCGCATTCTCC
TCCGCTGCGGGGCCGAGCTCTCCCCAGCGCTCGCAGGAAGGAAGAAGGGAGCCGAGGACGCCGAGAAGTTCCCGCGGCAGCCGCGGATCC
CGGCCAAGGCGGAGGCTGCGGCTCCGACGGGGCAGGAGCGCGATCCACGGCGAGGGGCGTACGGCCAAAGGGTCCGCGGCGTGGAGCGCT
CGGACCTTCCGCTCTCCCCCGGGCGTGGGCCGGGACCCCATGAGACGCGCCCACGAGGGGCGCGAGATTCCTAGCTTGGGCGGCGCTAGG
CGGAGGGAGGTGTTGCAGCCGCCGGAGCCAGAGAGCTGCCGGCAGGAGGCGGCGGCGGCAAGAACTTGAACTTGGCGTCGGGAGCGGGCG
CCCCGGACGCCCCCCGCCGGGGCCGGGGCGCCGAGGGACCTGCGCCGCAGCGCTGCCCCCCGAATGGCCGCGGCGGCGGACCGGGCTCCC
GCGCCGCGGCCCTAGGCGGCCTCTCGCCATGGCCAAGTGGCTAAACAAGTACTTCAGCTTGGGCAACAGCAAGACCAAGAGCCCCCCGCA
GCCGCCGCGGCCAGACTACCGCGAGCAGCGGCGCCGAGGCGAGCGGCCTTCGCAGCCCCCCCAGGCCGTGCCGCAGGCCTCCTCCGCCGC
CTCGGCGTCCTGCGGTCCGGCCACCGCCTCCTGCTTCTCAGCCTCTTCGGGCTCGCTGCCCGACGACAGCGGCAGCACCAGCGACCTCAT
CCGCGCCTACCGCGCGCAGAAGGAGCGAGACTTCGAGGACCCCTACAACGGGCCTGGCTCGTCGCTGCGCAAACTGCGCGCCATGTGCCG
CCTGGACTACTGCGGCGGCAGCGGGGAGCCAGGCGGGGTCCAGCGCGCCTTCTCGGCCTCGTCCGCGTCGGGCGCCGCGGGCTGTTGCTG
CGCCTCCTCGGGCGCGGGGGCCGCCGCGTCCTCGTCCTCGTCCTCCGGCTCTCCGCATCTCTACCGCAGCAGCAGCGAGCGGCGGCCCGC
CACGCCGGCCGAGGTGCGCTACATCTCCCCCAAGCACCGCCTCATCAAAGTGGAGAGCGCCGCGGGCGGTGGGGCCGGGGACCCCCTGGG
GGGCGCCTGCGCGGGCGGCCGCACCTGGAGCCCGACGGCCTGCGGAGGCAAGAAACTGCTCAACAAGTGCGCCGCCTCAGCCGCGGAGGA
GAGCGGGGCCGGCAAGAAGGACAAGGAAAAAAGAAAGAGGCAGACTGAAATAGAAGGCAAGCGACAACAGCTTGACGAGCAGATACTTCT
GCTGCAGCATTCCAAGTCCAAAGTGCTTCGGGAGAAATGGCTGCTGCAGGGCATACCCGCTGGAACTGCCGAAGAGGAGGAAGCCAGGAG
GCGGCAGTCTGAAGAGGATGAGTTCAGAGTCAAGCAACTTGAAGATAACATTCAGAGGCTGGAGCAAGAAATACAAACGCTAGAAAGTGA
AGAGTCCCAGATATCTGCCAAAGAGCAAATCATCCTAGAGAAACTGAAGGAAACAGAAAAATCCTTCAAGGACTTTCAGAAGGGTTTCTC
CAGTACGGATGGAGATGCAGTAAATTACATTTCCTCCCAGCTTCCCGACCTGCCAATCCTCTGTTCACGAACAGCAGAACCATCACCTGG
GCAGGACGGGACCAGCAGAGCGGCTGGAGTCGGGTGGGAGAATGTGCTGCTAAAGGAAGGTGAGTCAGCCTCGAACGCCACAGAAACATC
CGGCCCAGACATGACTATCAAGAAGCCTCCCCAGCTTTCTGAGGATGATATCTGGCTAAAAAGCGAGGGAGACAACTATAGTGCCACCCT
CCTGGAGCCTGCTGCCAGCTCTCTTTCCCCAGATCACAAAAACATGGAAATTGAGGTGTCTGTTGCAGAATGTAAAAGTGTTCCTGGAAT
CACCTCTACCCCACATCCCATGGACCATCCCTCCGCTTTCTATTCACCCCCGCATAATGGCCTCCTTACTGATCACCACGAATCCCTGGA
TAATGATGTTGCCAGAGAGATCCGCTATCTAGATGAGGTGCTAGAGGCCAACTGCTGTGATTCTGCTGTGGATGGAACGTACAATGGAAC
ATCCTCCCCAGAGCCTGGTGCAGTGGTTCTGGTGGGCGGCCTAAGCCCCCCTGTCCACGAGGCGACCCAGCCAGAACCCACTGAAAGAAC
AGCTAGCCGGCAGGCACCTCCTCACATCGAGCTCAGTAATAGCAGCCCTGACCCCATGGCAGAGGCAGAAAGAACAAATGGCCATTCCCC
CAGCCAGCCTAGAGATGCGCTGGGGGACAGCCTGCAGGTGCCTGTCAGCCCCAGCTCCACAACCAGCTCACGGTGTTCTTCCCGAGATGG
AGAGTTCACTCTCACCACACTGAAAAAGGAGGCCAAGTTTGAGCTGCGTGCCTTCCATGAGGACAAGAAGCCCTCCAAGCTCTTTGAGGA
TGACGAGCATGAGAAAGAACAATACTGCATTAGAAAAGTGAGGCCTTCAGAGGAGATGCTGGAGCTGGAAAAGGAGAGGAGAGAGCTCAT
CCGCAGCCAGGCCGTCAAGAAGAATCCTGGCATTGCAGCAAAATGGTGGAATCCCCCGCAGGAAAAAACCATCGAGGAGCAGCTGGACGA
GGAACATCTGGAGTCGCACAAAAAGTACAAGGAGCGCAAAGAGAGAAGGGCACAGCAGGAACAGTTGCTGCTGCAGAAGCAGTTACAGCA
GCAGCAGCAGCAGCCCCCATCGCAGCTCTGCACAGCCCCTGCCTCTTCTCATGAACGCGCAAGCATGATTGACAAAGCAAAGGAGGACAT
TGTCACAGAGCAGATAGATTTCTCTGCTGCTCGCAAACAATTTCAGCTGATGGAGAATTCCAGGCAAGCGGTGGCCAAGGGCCAGAGTAC
ACCCAGGCTGTTCTCCATCAAGCCTTTCTACAGGCCTCTGGGGTCAGTCAACTCAGACAAGCCACTGACTAATCCGAGACCACCTTCTGT
CGGGGGACCTCCAGAAGACAGTGGTGCCTCAGCCGCCAAGGGACAGAAATCCCCCGGTGCCCTGGAGACCCCATCGGCAGCAGGAAGCCA
GGGCAACACAGCCTCTCAGGGGAAGGAAGGGCCCTACAGCGAGCCTTCTAAACGTGGGCCCTTATCTAAACTGTGGGCTGAGGATGGAGA
ATTTACGAGCGCCCGGGCTGTCCTCACTGTGGTCAAGGATGATGACCATGGGATTTTGGATCAGTTCTCAAGATCTGTCAATGTCTCCTT
GACCCAAGAGGAGCTTGACTCTGGTCTGGACGAATTGTCGGTGAGGTCTCAGGATACCACAGTCCTGGAGACCCTATCCAATGATTTCAG
CATGGACAACATCAGTGACAGCGGGGCATCCAATGAGACAACCAATGCCCTCCAGGAAAATTCACTGGCTGATTTTTCTCTGCCCCAGAC
ACCACAAACTGACAACCCCTCAGAGGGCCGAGGAGAAGGCGTCTCCAAGTCATTTAGTGATCATGGTTTCTATTCCCCTTCCTCCACGCT
GGGGGACTCTCCGTTGGTTGATGACCCCTTGGAGTATCAGGCTGGCCTCCTGGTGCAGAATGCCATTCAACAAGCCATAGCCGAGCAGGT
GGATAAAGCTGTGTCCAAAACCAGCAGGGATGGAGCAGAGCAACAGGGACCTGAAGCGACTGTAGAGGAAGCTGAAGCTGCGGCTTTCGG
CTCAGAAAAGCCTCAGAGCATGTTTGAGCCACCTCAGGTGTCTTCTCCTGTTCAAGAGAAAAGGGATGTATTACCAAAGATTCTGCCTGC
TGAAGACAGGGCGCTCAGGGAAAGGGGGCCCCCCCAGCCACTGCCAGCTGTGCAGCCCAGTGGCCCGATTAACATGGAGGAGACCAGGCC
CGAAGGAAGCTATTTCAGCAAGTACTCGGAGGCAGCTGAGCTGAGAAGCACAGCCTCCCTCCTGGCCACTCAAGAATCTGACGTGATGGT
TGGGCCTTTCAAGCTGAGGTCCAGGAAACAGCGGACTTTGTCCATGATTGAGGAAGAGATCCGAGCAGCTCAGGAAAGGGAAGAGGAGCT
GAAGAGGCAGAGACAAGTCTTGCAGAGTACGCAGAGCCCCAGGACAAAGAATGCCCCATCACTGCCCTCCAGAACATGCTACAAAACTGC
TCCAGGGAAAATAGAGAAAGTCAAACCTCCTCCATCCCCCACCACTGAAGGCCCCAGCTTGCAGCCTGACTTAGCCCCTGAAGAGGCTGC
CGGAACCCAGCGGCCCAAGAATCTGATGCAGACCCTCATGGAAGACTATGAGACACACAAATCTAAAAGGCGCGAGAGAATGGATGATAG
TAGTTACACTTCTAAGTTACTGTCTTGCAAGGTGACTTCCGAGGTCCTCGAGGCCACACGGGTTAATCGAAGAAAGAGCGCACTGGCTTT
GCGCTGGGAAGCAGGGATCTATGCCAACCAGGAGGAAGAAGACAACGAATAAACTTCCTTCAACCCAGGAAGCGTCTTTGGTGCTTGGGA
GACCAAGAAACCAAGAAATTAACAACTGAAAGCATTTTAATGGACTATTTATTAAAGTGCAAACAAACTCAGCAATCCTTATGTAGACCA
GAAGCTGCAATATACAATGATGAAAATGAAACGAAAAGGAAGTCCCCCCATCAGACTCTGGACACCCAGGAATCAAAAGAGAAAGGACTT
TTTTGGTGACTCAATCCCAGTGTCTGGTTTGGGGCCAATCTACAATGGATCCAAAAGGACAAAACATGTTACAAGCAAATCAACATAGTT
GCTGCAGGCGGAACTGAGACCAGCCTCTCTGGGCGATGAAGGACAATGGTGGTAGGGCCACTTAGAGAGCAGTAGGGCCCAGGCTGGTGC
AGCCTACATGGCACAGGATATTTCCCTGCACCAGTTTCCCACCTGTCACTTGCAGCATCAGAGGGTGTTGCATTAACTCCATTTTCTCCA
GCAGCCATAAAATGAATGGCGTTTCTCTCCATATTTGCCCAGAAGAGGCAGTTATGATTCCACTTCTCCTACATTTAATTATTTTTAATT
GAGAACAACTCATGATCACAATTCATAAAATCCATATTTTAAGACAATAGTTCTTCATGTCACAAACACAATCTATTCTACATGAGGAGG
CTGAGAAAGGGGAAGAGAAAAACAAACCAAATGGATGATGTTAGCTTTAGGATCGTGTCTGCTTATAATATTCACTGATCTGCAGTTTAT
GAGAACACATTTTCACAGTTATGTTTCTTCATAGGAAAACTATATTTAGTGGGCAACAACTATTTTTATGATGGGATGGGGGAGTATATA
CACGTATAGAATCTGTACGCGTTGAACAACTTGGTTCAAGATGGTGGGGGCATTTTTAGAGCGGCAATAATTGAAAAAAAAGGCGAACTC
TGCCTTGGAGAGGTAGATGATAAGAAATAAAAAGGTGTTTATAACTATTTTGTATTATAAAGTGGGCCTTAGAGATAGGAAGAAGAATGA
TGGATTCCTTTTGGATCAATCAGAAAGGAAACACGAAAGAAAAGTCAGGAAGGTAGAGAGAGAAAAAGGGAGGGAAGGAGAAAGAATGGG
AATAAAATAAGGAGGTAAGAGATACTATTTTTGCTGAGCAACCAGTGTGTTTCAGGATGATACAAAGAAAAATATAGAATAGAAATAAGT
GCAGGCTTGGAATCAGCTACAAATCCTAAAGATGGGGTGTGTGTGGATGTGTGTGTGTGTGTGTGTACACCATTGTGTGTTTGTAAAATG
TGTATGTTCATGAGTAAGGGTGTGTGTGTGTGTGTATTAAAATTCCAGAGTGACCGTGGCACTTGGGTGTACAGGTAATTCCTCCAGAGC
TGTTTGCTGGCTTCAGGAGTGGAGTGAGAATTTCTTTTTTATGAAAAGGGATATAAAGGCACCGAGCTGATGCAGTATTTGTAATATTAA
GTTGACCTAACAAGGTATTTGCATGAGTCACAATTACAAAGTTTTGAGCGGTTTTGTAATTTGACATTTAGGAGAGTCTCCTATTTATTC
TCATACTTTACATTCATGCTTAGTATACTATAGAGGATGCCAGCTTTAATCTTTCTGTCATTTAAAGCAATATGATAAGGGTATTCAATA
ATTGGGTGCCCTAAATTTCTGGATGAGAAAATTTTCAATTCTGGCCATGAGAAAGAAAAAAAAATAAACAGCCTTCTTTTTTTTTCCTTT
GTTTTAAAACTGTGGTTTTTTAAAAAAGCAATAATTAACTCAGACCTCACTAAAAATCATTTTTGTTTTTATATTGTTATGTCATAAGCT
CTATTATGTTATTCTAACAAGTAGCAATTTCACAAAATTTGTATGTAGATGTTAACGCACATTTCCTTTGCTTCTTTTATTAGACTAGTG
TTGACTTTGGGGGGGGACATTTATTCACAAATGAGAAGTAGGCACAAAGTAAAAAATGGAACCATCTACTAACAAGGATCCTTTAAAACT
GCCAAGGGAGCTCTAACTTGAAGCCACATCCTACAGATGGCAGCCCAAATAGCACATGGGCAATTGGCACCATCTTTATATGGTTGAGTC
TCCTGAATATTTTGAATGAATTCTCAACAAAATGTGCTAGCCACTGGGGACGCAAAACAAGTAAGATCCCTGTTGCAAGAAATTCATTTT
ATAGTGAGGGAGGTTGGCATGGAGACTAAAATTCTCAGGAAAATGAGATCCGTGTTAGATTAGAAGTCCTGATGTGAAATGGGAGGACTC
AGGAAGGAGGATCGTCTTTACCTGAGGATTTCTAGCCAGAGGTCCCAGATGCCTGGGCTGAGAACCCAGCGATAAGGGGGCGTTCCCAAA
GCAGACACAGGGATAAGAACAGAGGAGGCAGCAGCATTGCACAGCCCCAGGCACAGTGGCAGTTAGGATGGCTGGAGAGTAGGATAGTTC
TATGGGTTGCCCAAAAAATGTGATGCGCTTCATGTTTTCTCTGACTCATGGATCTGGTAGAGACCATAGACATGATATAGACTAACTTCC
CCATTTTTCACAAGAGGAAACCATCCTTATGACTTACCTTAAAGTTTTTTGTTCTGTTTTGAAGGAAACCATGTGCTTCATGAAACCTAC
AGTTGACAAGAGAATGTACAGCTAAGAGAAAAGCTTAAGAGGCCACACTATTCGCGGAATGGCTTTAGAGGCAGATGAAGTGGTCTTTGA
CCACAGTTGATTGAACCAGAGCACTTATTGCTTAAAGAATAACAGAGTTCTAGAGCTGGGGGTTCTTGGGCCATGCTCCGTGTGTGGATA
AGGAAAGAAATACTGTTTCTGGGACTCTCCCACAGTCACAAAGCTGTTTTCACTGTGGCCCCTACATCTCTTAACTTTTGCTATTACTCC
TATGCTGCCTTCCGGATTACTGCTGTCTATCTTCTTGCTCCACTCACTGAAGATCCTATTATAATCCCATGAAAATGTAAATTACAGTTT
ACTTGGGAGAGCCAGATTTTCTCTGTGCTCTTGAGTTTTTTATTCATTCAAGAAACCTTGGGCCACCGCTTTGTACATAGCACCGTGCTA
GGCTCTGGGATCCCAAATGGACCCTTTTAACTTTCTGAAGATGGGACCGTCCCCTGGAGGAAAGTCATTCCTGCCTAATCCATCGAGAGA
AAGAGGCTTACGAAAAACTTTGCCTCTGATGCTCAGCCCCACCCCCAAATAGCACACAAGCTTGTTAACCCCACCTCTTACAAAATGTTT
AGATTCTGTAGGTGTTAAAAGCCTTTCTGGAAGTATTGCATTCTGCCGTGTTTATAGGTGTTCACTTTCCTCCAGAGCTGATTAACTACT
GACATGACTTGGCTTTCTCATCCAGAAATTATGGAAACAGGGTCTGTCAGTGGCAGGAGGCCGTGCTGTGTTTTACTTGGATGACACAAT
GCAGTTTACTTGCCTCTTCATACCCATGCATGCTGCTCACCCTAGACAATGACATATAAGCCGTATATAGATCAATGTCCACATATATAT
ACACACACACATATATATATATAAAGTGTAACAAGGAACACTAAAACAGTGTTGATTCTTGTCTCTGAAGACAAATAATTAAACCTTTTT
TTTCCCAACTAAAGAATGGATTTAATTAAACTATGTATTGAAAAAAAAGTAGCCTAAGTGTTAGAGATGGTGAATATATTCCATTTTAGT
TAAAGAACAAATTTCCTGAATTTTAAGCATTCAGTGAGCTGCCAATTTTGATTTTGTGTTGCTCTTTACCCAAATTATTTTTTCTTTGTT
TTTCTTTTTTTGGGGGAGGAGGGGAAAAAAGCAGCAATACTGTGTTTGGAAATTATACTCTGTATCTGGTTTTCCTGTGTATGTTAACCA
CTTAAATGTTATTATCCTGCTTTGGTTTTAGAGTGATTGTGAGGCATTCAATGCAAGTATACAGTTATTTTCTCATTAAAATCCAATGTG

>81627_81627_2_SHB-PALM2-AKAP2_SHB_chr9_38067926_ENST00000377700_PALM2-AKAP2_chr9_112629771_ENST00000374530_length(amino acids)=1349AA_BP=260
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKEKRKRQTEI
EGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKE
TEKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAGVGWENVLLKEGESASNATETSGPDMTIKKPPQLSEDDI
WLKSEGDNYSATLLEPAASSLSPDHKNMEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVLEAN
CCDSAVDGTYNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVPVSP
SSTTSSRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAKWWN
PPQEKTIEEQLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKAKEDIVTEQIDFSAARKQFQLM
ENSRQAVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPRPPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSEPSK
RGPLSKLWAEDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETTNAL
QENSLADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSPSSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGP
EATVEEAEAAAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINMEETRPEGSYFSKYSEAAELRST
ASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEG

--------------------------------------------------------------
>81627_81627_3_SHB-PALM2-AKAP2_SHB_chr9_38067926_ENST00000377707_PALM2-AKAP2_chr9_112629771_ENST00000302798_length(transcript)=5923nt_BP=1283nt
GCCGCCGGGACGGGCACGGGCGCGCGGGCTCCGGCGGGCGCCGGCTGCCTTCCTCCGTCGCTCGCTGTCTCTCCCGGCCGCATTCTCCTC
CGCTGCGGGGCCGAGCTCTCCCCAGCGCTCGCAGGAAGGAAGAAGGGAGCCGAGGACGCCGAGAAGTTCCCGCGGCAGCCGCGGATCCCG
GCCAAGGCGGAGGCTGCGGCTCCGACGGGGCAGGAGCGCGATCCACGGCGAGGGGCGTACGGCCAAAGGGTCCGCGGCGTGGAGCGCTCG
GACCTTCCGCTCTCCCCCGGGCGTGGGCCGGGACCCCATGAGACGCGCCCACGAGGGGCGCGAGATTCCTAGCTTGGGCGGCGCTAGGCG
GAGGGAGGTGTTGCAGCCGCCGGAGCCAGAGAGCTGCCGGCAGGAGGCGGCGGCGGCAAGAACTTGAACTTGGCGTCGGGAGCGGGCGCC
CCGGACGCCCCCCGCCGGGGCCGGGGCGCCGAGGGACCTGCGCCGCAGCGCTGCCCCCCGAATGGCCGCGGCGGCGGACCGGGCTCCCGC
GCCGCGGCCCTAGGCGGCCTCTCGCCATGGCCAAGTGGCTAAACAAGTACTTCAGCTTGGGCAACAGCAAGACCAAGAGCCCCCCGCAGC
CGCCGCGGCCAGACTACCGCGAGCAGCGGCGCCGAGGCGAGCGGCCTTCGCAGCCCCCCCAGGCCGTGCCGCAGGCCTCCTCCGCCGCCT
CGGCGTCCTGCGGTCCGGCCACCGCCTCCTGCTTCTCAGCCTCTTCGGGCTCGCTGCCCGACGACAGCGGCAGCACCAGCGACCTCATCC
GCGCCTACCGCGCGCAGAAGGAGCGAGACTTCGAGGACCCCTACAACGGGCCTGGCTCGTCGCTGCGCAAACTGCGCGCCATGTGCCGCC
TGGACTACTGCGGCGGCAGCGGGGAGCCAGGCGGGGTCCAGCGCGCCTTCTCGGCCTCGTCCGCGTCGGGCGCCGCGGGCTGTTGCTGCG
CCTCCTCGGGCGCGGGGGCCGCCGCGTCCTCGTCCTCGTCCTCCGGCTCTCCGCATCTCTACCGCAGCAGCAGCGAGCGGCGGCCCGCCA
CGCCGGCCGAGGTGCGCTACATCTCCCCCAAGCACCGCCTCATCAAAGTGGAGAGCGCCGCGGGCGGTGGGGCCGGGGACCCCCTGGGGG
GCGCCTGCGCGGGCGGCCGCACCTGGAGCCCGACGGCCTGCGGAGGCAAGAAACTGCTCAACAAGTGCGCCGCCTCAGCCGCGGAGGAGA
GCGGGGCCGGCAAGAAGGACAAGGAAAAAAGAAAGAGGCAGACTGAAATAGAAGGCAAGCGACAACAGCTTGACGAGCAGATACTTCTGC
TGCAGCATTCCAAGTCCAAAGTGCTTCGGGAGAAATGGCTGCTGCAGGGCATACCCGCTGGAACTGCCGAAGAGGAGGAAGCCAGGAGGC
GGCAGTCTGAAGAGGATGAGTTCAGAGTCAAGCAACTTGAAGATAACATTCAGAGGCTGGAGCAAGAAATACAAACGCTAGAAAGTGAAG
AGTCCCAGATATCTGCCAAAGAGCAAATCATCCTAGAGAAACTGAAGGAAACAGAAAAATCCTTCAAGGACTTTCAGAAGGGTTTCTCCA
GTACGGATGGAGATGCAGTAAATTACATTTCCTCCCAGCTTCCCGACCTGCCAATCCTCTGTTCACGAACAGCAGAACCATCACCTGGGC
AGGACGGGACCAGCAGAGCGGCTGGAGTCGGGTGGGAGAATGTGCTGCTAAAGGAAGGTGAGTCAGCCTCGAACGCCACAGAAACATCCG
GCCCAGACATGACTATCAAGAAGCCTCCCCAGCTTTCTGAGGATGATATCTGGCTAAAAAGCGAGGGAGACAACTATAGTGCCACCCTCC
TGGAGCCTGCTGCCAGCTCTCTTTCCCCAGATCACAAAAACATGGAAATTGAGGTGTCTGTTGCAGAATGTAAAAGTGTTCCTGGAATCA
CCTCTACCCCACATCCCATGGACCATCCCTCCGCTTTCTATTCACCCCCGCATAATGGCCTCCTTACTGATCACCACGAATCCCTGGATA
ATGATGTTGCCAGAGAGATCCGCTATCTAGATGAGGTGCTAGAGGCCAACTGCTGTGATTCTGCTGTGGATGGAACGTACAATGGAACAT
CCTCCCCAGAGCCTGGTGCAGTGGTTCTGGTGGGCGGCCTAAGCCCCCCTGTCCACGAGGCGACCCAGCCAGAACCCACTGAAAGAACAG
CTAGCCGGCAGGCACCTCCTCACATCGAGCTCAGTAATAGCAGCCCTGACCCCATGGCAGAGGCAGAAAGAACAAATGGCCATTCCCCCA
GCCAGCCTAGAGATGCGCTGGGGGACAGCCTGCAGGTGCCTGTCAGCCCCAGCTCCACAACCAGCTCACGGTGTTCTTCCCGAGATGGAG
AGTTCACTCTCACCACACTGAAAAAGGAGGCCAAGTTTGAGCTGCGTGCCTTCCATGAGGACAAGAAGCCCTCCAAGCTCTTTGAGGATG
ACGAGCATGAGAAAGAACAATACTGCATTAGAAAAGTGAGGCCTTCAGAGGAGATGCTGGAGCTGGAAAAGGAGAGGAGAGAGCTCATCC
GCAGCCAGGCCGTCAAGAAGAATCCTGGCATTGCAGCAAAATGGTGGAATCCCCCGCAGGAAAAAACCATCGAGGAGCAGCTGGACGAGG
AACATCTGGAGTCGCACAAAAAGTACAAGGAGCGCAAAGAGAGAAGGGCACAGCAGGAACAGTTGCTGCTGCAGAAGCAGTTACAGCAGC
AGCAGCAGCAGCCCCCATCGCAGCTCTGCACAGCCCCTGCCTCTTCTCATGAACGCGCAAGCATGATTGACAAAGCAAAGGAGGACATTG
TCACAGAGCAGATAGATTTCTCTGCTGCTCGCAAACAATTTCAGCTGATGGAGAATTCCAGGCAAGCGGTGGCCAAGGGCCAGAGTACAC
CCAGGCTGTTCTCCATCAAGCCTTTCTACAGGCCTCTGGGGTCAGTCAACTCAGACAAGCCACTGACTAATCCGAGACCACCTTCTGTCG
GGGGACCTCCAGAAGACAGTGGTGCCTCAGCCGCCAAGGGACAGAAATCCCCCGGTGCCCTGGAGACCCCATCGGCAGCAGGAAGCCAGG
GCAACACAGCCTCTCAGGGGAAGGAAGGGCCCTACAGCGAGCCTTCTAAACGTGGGCCCTTATCTAAACTGTGGGCTGAGGATGGAGAAT
TTACGAGCGCCCGGGCTGTCCTCACTGTGGTCAAGGATGATGACCATGGGATTTTGGATCAGTTCTCAAGATCTGTCAATGTCTCCTTGA
CCCAAGAGGAGCTTGACTCTGGTCTGGACGAATTGTCGGTGAGGTCTCAGGATACCACAGTCCTGGAGACCCTATCCAATGATTTCAGCA
TGGACAACATCAGTGACAGCGGGGCATCCAATGAGACAACCAATGCCCTCCAGGAAAATTCACTGGCTGATTTTTCTCTGCCCCAGACAC
CACAAACTGACAACCCCTCAGAGGGCCGAGGAGAAGGCGTCTCCAAGTCATTTAGTGATCATGGTTTCTATTCCCCTTCCTCCACGCTGG
GGGACTCTCCGTTGGTTGATGACCCCTTGGAGTATCAGGCTGGCCTCCTGGTGCAGAATGCCATTCAACAAGCCATAGCCGAGCAGGTGG
ATAAAGCTGTGTCCAAAACCAGCAGGGATGGAGCAGAGCAACAGGGACCTGAAGCGACTGTAGAGGAAGCTGAAGCTGCGGCTTTCGGCT
CAGAAAAGCCTCAGAGCATGTTTGAGCCACCTCAGGTGTCTTCTCCTGTTCAAGAGAAAAGGGATGTATTACCAAAGATTCTGCCTGCTG
AAGACAGGGCGCTCAGGGAAAGGGGGCCCCCCCAGCCACTGCCAGCTGTGCAGCCCAGTGGCCCGATTAACATGGAGGAGACCAGGCCCG
AAGGAAGCTATTTCAGCAAGTACTCGGAGGCAGCTGAGCTGAGAAGCACAGCCTCCCTCCTGGCCACTCAAGAATCTGACGTGATGGTTG
GGCCTTTCAAGCTGAGGTCCAGGAAACAGCGGACTTTGTCCATGATTGAGGAAGAGATCCGAGCAGCTCAGGAAAGGGAAGAGGAGCTGA
AGAGGCAGAGACAAGTCTTGCAGAGTACGCAGAGCCCCAGGACAAAGAATGCCCCATCACTGCCCTCCAGAACATGCTACAAAACTGCTC
CAGGGAAAATAGAGAAAGTCAAACCTCCTCCATCCCCCACCACTGAAGGCCCCAGCTTGCAGCCTGACTTAGCCCCTGAAGAGGCTGCCG
GAACCCAGCGGCCCAAGAATCTGATGCAGACCCTCATGGAAGACTATGAGACACACAAATCTAAAAGGCGCGAGAGAATGGATGATAGTA
GTGTCCTCGAGGCCACACGGGTTAATCGAAGAAAGAGCGCACTGGCTTTGCGCTGGGAAGCAGGGATCTATGCCAACCAGGAGGAAGAAG
ACAACGAATAAACTTCCTTCAACCCAGGAAGCGTCTTTGGTGCTTGGGAGACCAAGAAACCAAGAAATTAACAACTGAAAGCATTTTAAT
GGACTATTTATTAAAGTGCAAACAAACTCAGCAATCCTTATGTAGACCAGAAGCTGCAATATACAATGATGAAAATGAAACGAAAAGGAA
GTCCCCCCATCAGACTCTGGACACCCAGGAATCAAAAGAGAAAGGACTTTTTTGGTGACTCAATCCCAGTGTCTGGTTTGGGGCCAATCT
ACAATGGATCCAAAAGGACAAAACATGTTACAAGCAAATCAACATAGTTGCTGCAGGCGGAACTGAGACCAGCCTCTCTGGGCGATGAAG
GACAATGGTGGTAGGGCCACTTAGAGAGCAGTAGGGCCCAGGCTGGTGCAGCCTACATGGCACAGGATATTTCCCTGCACCAGTTTCCCA
CCTGTCACTTGCAGCATCAGAGGGTGTTGCATTAACTCCATTTTCTCCAGCAGCCATAAAATGAATGGCGTTTCTCTCCATATTTGCCCA
GAAGAGGCAGTTATGATTCCACTTCTCCTACATTTAATTATTTTTAATTGAGAACAACTCATGATCACAATTCATAAAATCCATATTTTA
AGACAATAGTTCTTCATGTCACAAACACAATCTATTCTACATGAGGAGGCTGAGAAAGGGGAAGAGAAAAACAAACCAAATGGATGATGT
TAGCTTTAGGATCGTGTCTGCTTATAATATTCACTGATCTGCAGTTTATGAGAACACATTTTCACAGTTATGTTTCTTCATAGGAAAACT
ATATTTAGTGGGCAACAACTATTTTTATGATGGGATGGGGGAGTATATACACGTATAGAATCTGTACGCGTTGAACAACTTGGTTCAAGA
TGGTGGGGGCATTTTTAGAGCGGCAATAATTGAAAAAAAAGGCGAACTCTGCCTTGGAGAGGTAGATGATAAGAAATAAAAAGGTGTTTA
TAACTATTTTGTATTATAAAGTGGGCCTTAGAGATAGGAAGAAGAATGATGGATTCCTTTTGGATCAATCAGAAAGGAAACACGAAAGAA
AAGTCAGGAAGGTAGAGAGAGAAAAAGGGAGGGAAGGAGAAAGAATGGGAATAAAATAAGGAGGTAAGAGATACTATTTTTGCTGAGCAA
CCAGTGTGTTTCAGGATGATACAAAGAAAAATATAGAATAGAAATAAGTGCAGGCTTGGAATCAGCTACAAATCCTAAAGATGGGGTGTG
TGTGGATGTGTGTGTGTGTGTGTGTACACCATTGTGTGTTTGTAAAATGTGTATGTTCATGAGTAAGGGTGTGTGTGTGTGTGTATTAAA

>81627_81627_3_SHB-PALM2-AKAP2_SHB_chr9_38067926_ENST00000377707_PALM2-AKAP2_chr9_112629771_ENST00000302798_length(amino acids)=1336AA_BP=260
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKEKRKRQTEI
EGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKE
TEKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAGVGWENVLLKEGESASNATETSGPDMTIKKPPQLSEDDI
WLKSEGDNYSATLLEPAASSLSPDHKNMEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVLEAN
CCDSAVDGTYNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVPVSP
SSTTSSRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAKWWN
PPQEKTIEEQLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKAKEDIVTEQIDFSAARKQFQLM
ENSRQAVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPRPPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSEPSK
RGPLSKLWAEDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETTNAL
QENSLADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSPSSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGP
EATVEEAEAAAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINMEETRPEGSYFSKYSEAAELRST
ASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEG

--------------------------------------------------------------
>81627_81627_4_SHB-PALM2-AKAP2_SHB_chr9_38067926_ENST00000377707_PALM2-AKAP2_chr9_112629771_ENST00000374530_length(transcript)=8565nt_BP=1283nt
GCCGCCGGGACGGGCACGGGCGCGCGGGCTCCGGCGGGCGCCGGCTGCCTTCCTCCGTCGCTCGCTGTCTCTCCCGGCCGCATTCTCCTC
CGCTGCGGGGCCGAGCTCTCCCCAGCGCTCGCAGGAAGGAAGAAGGGAGCCGAGGACGCCGAGAAGTTCCCGCGGCAGCCGCGGATCCCG
GCCAAGGCGGAGGCTGCGGCTCCGACGGGGCAGGAGCGCGATCCACGGCGAGGGGCGTACGGCCAAAGGGTCCGCGGCGTGGAGCGCTCG
GACCTTCCGCTCTCCCCCGGGCGTGGGCCGGGACCCCATGAGACGCGCCCACGAGGGGCGCGAGATTCCTAGCTTGGGCGGCGCTAGGCG
GAGGGAGGTGTTGCAGCCGCCGGAGCCAGAGAGCTGCCGGCAGGAGGCGGCGGCGGCAAGAACTTGAACTTGGCGTCGGGAGCGGGCGCC
CCGGACGCCCCCCGCCGGGGCCGGGGCGCCGAGGGACCTGCGCCGCAGCGCTGCCCCCCGAATGGCCGCGGCGGCGGACCGGGCTCCCGC
GCCGCGGCCCTAGGCGGCCTCTCGCCATGGCCAAGTGGCTAAACAAGTACTTCAGCTTGGGCAACAGCAAGACCAAGAGCCCCCCGCAGC
CGCCGCGGCCAGACTACCGCGAGCAGCGGCGCCGAGGCGAGCGGCCTTCGCAGCCCCCCCAGGCCGTGCCGCAGGCCTCCTCCGCCGCCT
CGGCGTCCTGCGGTCCGGCCACCGCCTCCTGCTTCTCAGCCTCTTCGGGCTCGCTGCCCGACGACAGCGGCAGCACCAGCGACCTCATCC
GCGCCTACCGCGCGCAGAAGGAGCGAGACTTCGAGGACCCCTACAACGGGCCTGGCTCGTCGCTGCGCAAACTGCGCGCCATGTGCCGCC
TGGACTACTGCGGCGGCAGCGGGGAGCCAGGCGGGGTCCAGCGCGCCTTCTCGGCCTCGTCCGCGTCGGGCGCCGCGGGCTGTTGCTGCG
CCTCCTCGGGCGCGGGGGCCGCCGCGTCCTCGTCCTCGTCCTCCGGCTCTCCGCATCTCTACCGCAGCAGCAGCGAGCGGCGGCCCGCCA
CGCCGGCCGAGGTGCGCTACATCTCCCCCAAGCACCGCCTCATCAAAGTGGAGAGCGCCGCGGGCGGTGGGGCCGGGGACCCCCTGGGGG
GCGCCTGCGCGGGCGGCCGCACCTGGAGCCCGACGGCCTGCGGAGGCAAGAAACTGCTCAACAAGTGCGCCGCCTCAGCCGCGGAGGAGA
GCGGGGCCGGCAAGAAGGACAAGGAAAAAAGAAAGAGGCAGACTGAAATAGAAGGCAAGCGACAACAGCTTGACGAGCAGATACTTCTGC
TGCAGCATTCCAAGTCCAAAGTGCTTCGGGAGAAATGGCTGCTGCAGGGCATACCCGCTGGAACTGCCGAAGAGGAGGAAGCCAGGAGGC
GGCAGTCTGAAGAGGATGAGTTCAGAGTCAAGCAACTTGAAGATAACATTCAGAGGCTGGAGCAAGAAATACAAACGCTAGAAAGTGAAG
AGTCCCAGATATCTGCCAAAGAGCAAATCATCCTAGAGAAACTGAAGGAAACAGAAAAATCCTTCAAGGACTTTCAGAAGGGTTTCTCCA
GTACGGATGGAGATGCAGTAAATTACATTTCCTCCCAGCTTCCCGACCTGCCAATCCTCTGTTCACGAACAGCAGAACCATCACCTGGGC
AGGACGGGACCAGCAGAGCGGCTGGAGTCGGGTGGGAGAATGTGCTGCTAAAGGAAGGTGAGTCAGCCTCGAACGCCACAGAAACATCCG
GCCCAGACATGACTATCAAGAAGCCTCCCCAGCTTTCTGAGGATGATATCTGGCTAAAAAGCGAGGGAGACAACTATAGTGCCACCCTCC
TGGAGCCTGCTGCCAGCTCTCTTTCCCCAGATCACAAAAACATGGAAATTGAGGTGTCTGTTGCAGAATGTAAAAGTGTTCCTGGAATCA
CCTCTACCCCACATCCCATGGACCATCCCTCCGCTTTCTATTCACCCCCGCATAATGGCCTCCTTACTGATCACCACGAATCCCTGGATA
ATGATGTTGCCAGAGAGATCCGCTATCTAGATGAGGTGCTAGAGGCCAACTGCTGTGATTCTGCTGTGGATGGAACGTACAATGGAACAT
CCTCCCCAGAGCCTGGTGCAGTGGTTCTGGTGGGCGGCCTAAGCCCCCCTGTCCACGAGGCGACCCAGCCAGAACCCACTGAAAGAACAG
CTAGCCGGCAGGCACCTCCTCACATCGAGCTCAGTAATAGCAGCCCTGACCCCATGGCAGAGGCAGAAAGAACAAATGGCCATTCCCCCA
GCCAGCCTAGAGATGCGCTGGGGGACAGCCTGCAGGTGCCTGTCAGCCCCAGCTCCACAACCAGCTCACGGTGTTCTTCCCGAGATGGAG
AGTTCACTCTCACCACACTGAAAAAGGAGGCCAAGTTTGAGCTGCGTGCCTTCCATGAGGACAAGAAGCCCTCCAAGCTCTTTGAGGATG
ACGAGCATGAGAAAGAACAATACTGCATTAGAAAAGTGAGGCCTTCAGAGGAGATGCTGGAGCTGGAAAAGGAGAGGAGAGAGCTCATCC
GCAGCCAGGCCGTCAAGAAGAATCCTGGCATTGCAGCAAAATGGTGGAATCCCCCGCAGGAAAAAACCATCGAGGAGCAGCTGGACGAGG
AACATCTGGAGTCGCACAAAAAGTACAAGGAGCGCAAAGAGAGAAGGGCACAGCAGGAACAGTTGCTGCTGCAGAAGCAGTTACAGCAGC
AGCAGCAGCAGCCCCCATCGCAGCTCTGCACAGCCCCTGCCTCTTCTCATGAACGCGCAAGCATGATTGACAAAGCAAAGGAGGACATTG
TCACAGAGCAGATAGATTTCTCTGCTGCTCGCAAACAATTTCAGCTGATGGAGAATTCCAGGCAAGCGGTGGCCAAGGGCCAGAGTACAC
CCAGGCTGTTCTCCATCAAGCCTTTCTACAGGCCTCTGGGGTCAGTCAACTCAGACAAGCCACTGACTAATCCGAGACCACCTTCTGTCG
GGGGACCTCCAGAAGACAGTGGTGCCTCAGCCGCCAAGGGACAGAAATCCCCCGGTGCCCTGGAGACCCCATCGGCAGCAGGAAGCCAGG
GCAACACAGCCTCTCAGGGGAAGGAAGGGCCCTACAGCGAGCCTTCTAAACGTGGGCCCTTATCTAAACTGTGGGCTGAGGATGGAGAAT
TTACGAGCGCCCGGGCTGTCCTCACTGTGGTCAAGGATGATGACCATGGGATTTTGGATCAGTTCTCAAGATCTGTCAATGTCTCCTTGA
CCCAAGAGGAGCTTGACTCTGGTCTGGACGAATTGTCGGTGAGGTCTCAGGATACCACAGTCCTGGAGACCCTATCCAATGATTTCAGCA
TGGACAACATCAGTGACAGCGGGGCATCCAATGAGACAACCAATGCCCTCCAGGAAAATTCACTGGCTGATTTTTCTCTGCCCCAGACAC
CACAAACTGACAACCCCTCAGAGGGCCGAGGAGAAGGCGTCTCCAAGTCATTTAGTGATCATGGTTTCTATTCCCCTTCCTCCACGCTGG
GGGACTCTCCGTTGGTTGATGACCCCTTGGAGTATCAGGCTGGCCTCCTGGTGCAGAATGCCATTCAACAAGCCATAGCCGAGCAGGTGG
ATAAAGCTGTGTCCAAAACCAGCAGGGATGGAGCAGAGCAACAGGGACCTGAAGCGACTGTAGAGGAAGCTGAAGCTGCGGCTTTCGGCT
CAGAAAAGCCTCAGAGCATGTTTGAGCCACCTCAGGTGTCTTCTCCTGTTCAAGAGAAAAGGGATGTATTACCAAAGATTCTGCCTGCTG
AAGACAGGGCGCTCAGGGAAAGGGGGCCCCCCCAGCCACTGCCAGCTGTGCAGCCCAGTGGCCCGATTAACATGGAGGAGACCAGGCCCG
AAGGAAGCTATTTCAGCAAGTACTCGGAGGCAGCTGAGCTGAGAAGCACAGCCTCCCTCCTGGCCACTCAAGAATCTGACGTGATGGTTG
GGCCTTTCAAGCTGAGGTCCAGGAAACAGCGGACTTTGTCCATGATTGAGGAAGAGATCCGAGCAGCTCAGGAAAGGGAAGAGGAGCTGA
AGAGGCAGAGACAAGTCTTGCAGAGTACGCAGAGCCCCAGGACAAAGAATGCCCCATCACTGCCCTCCAGAACATGCTACAAAACTGCTC
CAGGGAAAATAGAGAAAGTCAAACCTCCTCCATCCCCCACCACTGAAGGCCCCAGCTTGCAGCCTGACTTAGCCCCTGAAGAGGCTGCCG
GAACCCAGCGGCCCAAGAATCTGATGCAGACCCTCATGGAAGACTATGAGACACACAAATCTAAAAGGCGCGAGAGAATGGATGATAGTA
GTTACACTTCTAAGTTACTGTCTTGCAAGGTGACTTCCGAGGTCCTCGAGGCCACACGGGTTAATCGAAGAAAGAGCGCACTGGCTTTGC
GCTGGGAAGCAGGGATCTATGCCAACCAGGAGGAAGAAGACAACGAATAAACTTCCTTCAACCCAGGAAGCGTCTTTGGTGCTTGGGAGA
CCAAGAAACCAAGAAATTAACAACTGAAAGCATTTTAATGGACTATTTATTAAAGTGCAAACAAACTCAGCAATCCTTATGTAGACCAGA
AGCTGCAATATACAATGATGAAAATGAAACGAAAAGGAAGTCCCCCCATCAGACTCTGGACACCCAGGAATCAAAAGAGAAAGGACTTTT
TTGGTGACTCAATCCCAGTGTCTGGTTTGGGGCCAATCTACAATGGATCCAAAAGGACAAAACATGTTACAAGCAAATCAACATAGTTGC
TGCAGGCGGAACTGAGACCAGCCTCTCTGGGCGATGAAGGACAATGGTGGTAGGGCCACTTAGAGAGCAGTAGGGCCCAGGCTGGTGCAG
CCTACATGGCACAGGATATTTCCCTGCACCAGTTTCCCACCTGTCACTTGCAGCATCAGAGGGTGTTGCATTAACTCCATTTTCTCCAGC
AGCCATAAAATGAATGGCGTTTCTCTCCATATTTGCCCAGAAGAGGCAGTTATGATTCCACTTCTCCTACATTTAATTATTTTTAATTGA
GAACAACTCATGATCACAATTCATAAAATCCATATTTTAAGACAATAGTTCTTCATGTCACAAACACAATCTATTCTACATGAGGAGGCT
GAGAAAGGGGAAGAGAAAAACAAACCAAATGGATGATGTTAGCTTTAGGATCGTGTCTGCTTATAATATTCACTGATCTGCAGTTTATGA
GAACACATTTTCACAGTTATGTTTCTTCATAGGAAAACTATATTTAGTGGGCAACAACTATTTTTATGATGGGATGGGGGAGTATATACA
CGTATAGAATCTGTACGCGTTGAACAACTTGGTTCAAGATGGTGGGGGCATTTTTAGAGCGGCAATAATTGAAAAAAAAGGCGAACTCTG
CCTTGGAGAGGTAGATGATAAGAAATAAAAAGGTGTTTATAACTATTTTGTATTATAAAGTGGGCCTTAGAGATAGGAAGAAGAATGATG
GATTCCTTTTGGATCAATCAGAAAGGAAACACGAAAGAAAAGTCAGGAAGGTAGAGAGAGAAAAAGGGAGGGAAGGAGAAAGAATGGGAA
TAAAATAAGGAGGTAAGAGATACTATTTTTGCTGAGCAACCAGTGTGTTTCAGGATGATACAAAGAAAAATATAGAATAGAAATAAGTGC
AGGCTTGGAATCAGCTACAAATCCTAAAGATGGGGTGTGTGTGGATGTGTGTGTGTGTGTGTGTACACCATTGTGTGTTTGTAAAATGTG
TATGTTCATGAGTAAGGGTGTGTGTGTGTGTGTATTAAAATTCCAGAGTGACCGTGGCACTTGGGTGTACAGGTAATTCCTCCAGAGCTG
TTTGCTGGCTTCAGGAGTGGAGTGAGAATTTCTTTTTTATGAAAAGGGATATAAAGGCACCGAGCTGATGCAGTATTTGTAATATTAAGT
TGACCTAACAAGGTATTTGCATGAGTCACAATTACAAAGTTTTGAGCGGTTTTGTAATTTGACATTTAGGAGAGTCTCCTATTTATTCTC
ATACTTTACATTCATGCTTAGTATACTATAGAGGATGCCAGCTTTAATCTTTCTGTCATTTAAAGCAATATGATAAGGGTATTCAATAAT
TGGGTGCCCTAAATTTCTGGATGAGAAAATTTTCAATTCTGGCCATGAGAAAGAAAAAAAAATAAACAGCCTTCTTTTTTTTTCCTTTGT
TTTAAAACTGTGGTTTTTTAAAAAAGCAATAATTAACTCAGACCTCACTAAAAATCATTTTTGTTTTTATATTGTTATGTCATAAGCTCT
ATTATGTTATTCTAACAAGTAGCAATTTCACAAAATTTGTATGTAGATGTTAACGCACATTTCCTTTGCTTCTTTTATTAGACTAGTGTT
GACTTTGGGGGGGGACATTTATTCACAAATGAGAAGTAGGCACAAAGTAAAAAATGGAACCATCTACTAACAAGGATCCTTTAAAACTGC
CAAGGGAGCTCTAACTTGAAGCCACATCCTACAGATGGCAGCCCAAATAGCACATGGGCAATTGGCACCATCTTTATATGGTTGAGTCTC
CTGAATATTTTGAATGAATTCTCAACAAAATGTGCTAGCCACTGGGGACGCAAAACAAGTAAGATCCCTGTTGCAAGAAATTCATTTTAT
AGTGAGGGAGGTTGGCATGGAGACTAAAATTCTCAGGAAAATGAGATCCGTGTTAGATTAGAAGTCCTGATGTGAAATGGGAGGACTCAG
GAAGGAGGATCGTCTTTACCTGAGGATTTCTAGCCAGAGGTCCCAGATGCCTGGGCTGAGAACCCAGCGATAAGGGGGCGTTCCCAAAGC
AGACACAGGGATAAGAACAGAGGAGGCAGCAGCATTGCACAGCCCCAGGCACAGTGGCAGTTAGGATGGCTGGAGAGTAGGATAGTTCTA
TGGGTTGCCCAAAAAATGTGATGCGCTTCATGTTTTCTCTGACTCATGGATCTGGTAGAGACCATAGACATGATATAGACTAACTTCCCC
ATTTTTCACAAGAGGAAACCATCCTTATGACTTACCTTAAAGTTTTTTGTTCTGTTTTGAAGGAAACCATGTGCTTCATGAAACCTACAG
TTGACAAGAGAATGTACAGCTAAGAGAAAAGCTTAAGAGGCCACACTATTCGCGGAATGGCTTTAGAGGCAGATGAAGTGGTCTTTGACC
ACAGTTGATTGAACCAGAGCACTTATTGCTTAAAGAATAACAGAGTTCTAGAGCTGGGGGTTCTTGGGCCATGCTCCGTGTGTGGATAAG
GAAAGAAATACTGTTTCTGGGACTCTCCCACAGTCACAAAGCTGTTTTCACTGTGGCCCCTACATCTCTTAACTTTTGCTATTACTCCTA
TGCTGCCTTCCGGATTACTGCTGTCTATCTTCTTGCTCCACTCACTGAAGATCCTATTATAATCCCATGAAAATGTAAATTACAGTTTAC
TTGGGAGAGCCAGATTTTCTCTGTGCTCTTGAGTTTTTTATTCATTCAAGAAACCTTGGGCCACCGCTTTGTACATAGCACCGTGCTAGG
CTCTGGGATCCCAAATGGACCCTTTTAACTTTCTGAAGATGGGACCGTCCCCTGGAGGAAAGTCATTCCTGCCTAATCCATCGAGAGAAA
GAGGCTTACGAAAAACTTTGCCTCTGATGCTCAGCCCCACCCCCAAATAGCACACAAGCTTGTTAACCCCACCTCTTACAAAATGTTTAG
ATTCTGTAGGTGTTAAAAGCCTTTCTGGAAGTATTGCATTCTGCCGTGTTTATAGGTGTTCACTTTCCTCCAGAGCTGATTAACTACTGA
CATGACTTGGCTTTCTCATCCAGAAATTATGGAAACAGGGTCTGTCAGTGGCAGGAGGCCGTGCTGTGTTTTACTTGGATGACACAATGC
AGTTTACTTGCCTCTTCATACCCATGCATGCTGCTCACCCTAGACAATGACATATAAGCCGTATATAGATCAATGTCCACATATATATAC
ACACACACATATATATATATAAAGTGTAACAAGGAACACTAAAACAGTGTTGATTCTTGTCTCTGAAGACAAATAATTAAACCTTTTTTT
TCCCAACTAAAGAATGGATTTAATTAAACTATGTATTGAAAAAAAAGTAGCCTAAGTGTTAGAGATGGTGAATATATTCCATTTTAGTTA
AAGAACAAATTTCCTGAATTTTAAGCATTCAGTGAGCTGCCAATTTTGATTTTGTGTTGCTCTTTACCCAAATTATTTTTTCTTTGTTTT
TCTTTTTTTGGGGGAGGAGGGGAAAAAAGCAGCAATACTGTGTTTGGAAATTATACTCTGTATCTGGTTTTCCTGTGTATGTTAACCACT
TAAATGTTATTATCCTGCTTTGGTTTTAGAGTGATTGTGAGGCATTCAATGCAAGTATACAGTTATTTTCTCATTAAAATCCAATGTGTG

>81627_81627_4_SHB-PALM2-AKAP2_SHB_chr9_38067926_ENST00000377707_PALM2-AKAP2_chr9_112629771_ENST00000374530_length(amino acids)=1349AA_BP=260
MPPEWPRRRTGLPRRGPRRPLAMAKWLNKYFSLGNSKTKSPPQPPRPDYREQRRRGERPSQPPQAVPQASSAASASCGPATASCFSASSG
SLPDDSGSTSDLIRAYRAQKERDFEDPYNGPGSSLRKLRAMCRLDYCGGSGEPGGVQRAFSASSASGAAGCCCASSGAGAAASSSSSSGS
PHLYRSSSERRPATPAEVRYISPKHRLIKVESAAGGGAGDPLGGACAGGRTWSPTACGGKKLLNKCAASAAEESGAGKKDKEKRKRQTEI
EGKRQQLDEQILLLQHSKSKVLREKWLLQGIPAGTAEEEEARRRQSEEDEFRVKQLEDNIQRLEQEIQTLESEESQISAKEQIILEKLKE
TEKSFKDFQKGFSSTDGDAVNYISSQLPDLPILCSRTAEPSPGQDGTSRAAGVGWENVLLKEGESASNATETSGPDMTIKKPPQLSEDDI
WLKSEGDNYSATLLEPAASSLSPDHKNMEIEVSVAECKSVPGITSTPHPMDHPSAFYSPPHNGLLTDHHESLDNDVAREIRYLDEVLEAN
CCDSAVDGTYNGTSSPEPGAVVLVGGLSPPVHEATQPEPTERTASRQAPPHIELSNSSPDPMAEAERTNGHSPSQPRDALGDSLQVPVSP
SSTTSSRCSSRDGEFTLTTLKKEAKFELRAFHEDKKPSKLFEDDEHEKEQYCIRKVRPSEEMLELEKERRELIRSQAVKKNPGIAAKWWN
PPQEKTIEEQLDEEHLESHKKYKERKERRAQQEQLLLQKQLQQQQQQPPSQLCTAPASSHERASMIDKAKEDIVTEQIDFSAARKQFQLM
ENSRQAVAKGQSTPRLFSIKPFYRPLGSVNSDKPLTNPRPPSVGGPPEDSGASAAKGQKSPGALETPSAAGSQGNTASQGKEGPYSEPSK
RGPLSKLWAEDGEFTSARAVLTVVKDDDHGILDQFSRSVNVSLTQEELDSGLDELSVRSQDTTVLETLSNDFSMDNISDSGASNETTNAL
QENSLADFSLPQTPQTDNPSEGRGEGVSKSFSDHGFYSPSSTLGDSPLVDDPLEYQAGLLVQNAIQQAIAEQVDKAVSKTSRDGAEQQGP
EATVEEAEAAAFGSEKPQSMFEPPQVSSPVQEKRDVLPKILPAEDRALRERGPPQPLPAVQPSGPINMEETRPEGSYFSKYSEAAELRST
ASLLATQESDVMVGPFKLRSRKQRTLSMIEEEIRAAQEREEELKRQRQVLQSTQSPRTKNAPSLPSRTCYKTAPGKIEKVKPPPSPTTEG

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Fusion Gene PPI Analysis for SHB-PALM2-AKAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SHB-PALM2-AKAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SHB-PALM2-AKAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource