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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SHC2-ZNF559 (FusionGDB2 ID:81651)

Fusion Gene Summary for SHC2-ZNF559

check button Fusion gene summary
Fusion gene informationFusion gene name: SHC2-ZNF559
Fusion gene ID: 81651
HgeneTgene
Gene symbol

SHC2

ZNF559

Gene ID

25759

84527

Gene nameSHC adaptor protein 2zinc finger protein 559
SynonymsSCK|SHCB|SLINBLA00121
Cytomap

19p13.3

19p13.2

Type of geneprotein-codingprotein-coding
DescriptionSHC-transforming protein 2SH2 domain protein C2SHC (Src homology 2 domain containing) transforming protein 2SHC-transforming protein Bneuronal Shc adaptor homologprotein Scksrc homology 2 domain-containing-transforming protein C2zinc finger protein 559putative protein product of Nbla00121
Modification date2020031320200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264554, ENST00000393883, 
ENST00000538743, ENST00000317221, 
ENST00000585352, ENST00000586255, 
ENST00000587557, ENST00000592896, 
ENST00000603380, ENST00000592504, 
Fusion gene scores* DoF score6 X 4 X 4=961 X 1 X 1=1
# samples 61
** MAII scorelog2(6/96*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: SHC2 [Title/Abstract] AND ZNF559 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSHC2(430684)-ZNF559(9451778), # samples:1
Anticipated loss of major functional domain due to fusion event.SHC2-ZNF559 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SHC2-ZNF559 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SHC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ZNF559 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-FX-A3NK-01ASHC2chr19

430684

-ZNF559chr19

9451778

+


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Fusion Gene ORF analysis for SHC2-ZNF559

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000264554ENST00000393883SHC2chr19

430684

-ZNF559chr19

9451778

+
5CDS-5UTRENST00000264554ENST00000538743SHC2chr19

430684

-ZNF559chr19

9451778

+
Frame-shiftENST00000264554ENST00000317221SHC2chr19

430684

-ZNF559chr19

9451778

+
Frame-shiftENST00000264554ENST00000585352SHC2chr19

430684

-ZNF559chr19

9451778

+
Frame-shiftENST00000264554ENST00000586255SHC2chr19

430684

-ZNF559chr19

9451778

+
Frame-shiftENST00000264554ENST00000587557SHC2chr19

430684

-ZNF559chr19

9451778

+
Frame-shiftENST00000264554ENST00000592896SHC2chr19

430684

-ZNF559chr19

9451778

+
Frame-shiftENST00000264554ENST00000603380SHC2chr19

430684

-ZNF559chr19

9451778

+
In-frameENST00000264554ENST00000592504SHC2chr19

430684

-ZNF559chr19

9451778

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264554SHC2chr19430684-ENST00000592504ZNF559chr199451778+2157117401541513

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264554ENST00000592504SHC2chr19430684-ZNF559chr199451778+0.0396743230.96032566

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Fusion Genomic Features for SHC2-ZNF559


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SHC2chr19430683-ZNF559chr199451777+0.0031235450.9968765
SHC2chr19430683-ZNF559chr199451777+0.0031235450.9968765

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SHC2-ZNF559


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:430684/chr19:9451778)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSHC2chr19:430684chr19:9451778ENST00000264554-913147_329391694.6666666666666DomainPID
TgeneZNF559chr19:430684chr19:9451778ENST0000031722147119_1415385.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZNF559chr19:430684chr19:9451778ENST0000031722147147_1795385.0Zinc fingerC2H2-type 3%3B degenerate
TgeneZNF559chr19:430684chr19:9451778ENST0000031722147185_2075385.0Zinc fingerC2H2-type 4%3B degenerate
TgeneZNF559chr19:430684chr19:9451778ENST0000031722147241_2635385.0Zinc fingerC2H2-type 5
TgeneZNF559chr19:430684chr19:9451778ENST0000031722147297_3195385.0Zinc fingerC2H2-type 6
TgeneZNF559chr19:430684chr19:9451778ENST0000031722147325_3475385.0Zinc fingerC2H2-type 7
TgeneZNF559chr19:430684chr19:9451778ENST0000031722147353_3755385.0Zinc fingerC2H2-type 8
TgeneZNF559chr19:430684chr19:9451778ENST0000031722147381_4035385.0Zinc fingerC2H2-type 9
TgeneZNF559chr19:430684chr19:9451778ENST0000031722147409_4315385.0Zinc fingerC2H2-type 10
TgeneZNF559chr19:430684chr19:9451778ENST0000031722147437_4595385.0Zinc fingerC2H2-type 11
TgeneZNF559chr19:430684chr19:9451778ENST0000031722147465_4875385.0Zinc fingerC2H2-type 12
TgeneZNF559chr19:430684chr19:9451778ENST0000031722147493_5155385.0Zinc fingerC2H2-type 13
TgeneZNF559chr19:430684chr19:9451778ENST000003172214791_1135385.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF559chr19:430684chr19:9451778ENST0000039388336119_14153539.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZNF559chr19:430684chr19:9451778ENST0000039388336147_17953539.0Zinc fingerC2H2-type 3%3B degenerate
TgeneZNF559chr19:430684chr19:9451778ENST0000039388336185_20753539.0Zinc fingerC2H2-type 4%3B degenerate
TgeneZNF559chr19:430684chr19:9451778ENST0000039388336241_26353539.0Zinc fingerC2H2-type 5
TgeneZNF559chr19:430684chr19:9451778ENST0000039388336297_31953539.0Zinc fingerC2H2-type 6
TgeneZNF559chr19:430684chr19:9451778ENST0000039388336325_34753539.0Zinc fingerC2H2-type 7
TgeneZNF559chr19:430684chr19:9451778ENST0000039388336353_37553539.0Zinc fingerC2H2-type 8
TgeneZNF559chr19:430684chr19:9451778ENST0000039388336381_40353539.0Zinc fingerC2H2-type 9
TgeneZNF559chr19:430684chr19:9451778ENST0000039388336409_43153539.0Zinc fingerC2H2-type 10
TgeneZNF559chr19:430684chr19:9451778ENST0000039388336437_45953539.0Zinc fingerC2H2-type 11
TgeneZNF559chr19:430684chr19:9451778ENST0000039388336465_48753539.0Zinc fingerC2H2-type 12
TgeneZNF559chr19:430684chr19:9451778ENST0000039388336493_51553539.0Zinc fingerC2H2-type 13
TgeneZNF559chr19:430684chr19:9451778ENST000003938833691_11353539.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF559chr19:430684chr19:9451778ENST0000058535236119_1415385.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZNF559chr19:430684chr19:9451778ENST0000058535236147_1795385.0Zinc fingerC2H2-type 3%3B degenerate
TgeneZNF559chr19:430684chr19:9451778ENST0000058535236185_2075385.0Zinc fingerC2H2-type 4%3B degenerate
TgeneZNF559chr19:430684chr19:9451778ENST0000058535236241_2635385.0Zinc fingerC2H2-type 5
TgeneZNF559chr19:430684chr19:9451778ENST0000058535236297_3195385.0Zinc fingerC2H2-type 6
TgeneZNF559chr19:430684chr19:9451778ENST0000058535236325_3475385.0Zinc fingerC2H2-type 7
TgeneZNF559chr19:430684chr19:9451778ENST0000058535236353_3755385.0Zinc fingerC2H2-type 8
TgeneZNF559chr19:430684chr19:9451778ENST0000058535236381_4035385.0Zinc fingerC2H2-type 9
TgeneZNF559chr19:430684chr19:9451778ENST0000058535236409_4315385.0Zinc fingerC2H2-type 10
TgeneZNF559chr19:430684chr19:9451778ENST0000058535236437_4595385.0Zinc fingerC2H2-type 11
TgeneZNF559chr19:430684chr19:9451778ENST0000058535236465_4875385.0Zinc fingerC2H2-type 12
TgeneZNF559chr19:430684chr19:9451778ENST0000058535236493_5155385.0Zinc fingerC2H2-type 13
TgeneZNF559chr19:430684chr19:9451778ENST000005853523691_1135385.0Zinc fingerC2H2-type 1%3B degenerate
TgeneZNF559chr19:430684chr19:9451778ENST0000060338036119_14153539.0Zinc fingerC2H2-type 2%3B degenerate
TgeneZNF559chr19:430684chr19:9451778ENST0000060338036147_17953539.0Zinc fingerC2H2-type 3%3B degenerate
TgeneZNF559chr19:430684chr19:9451778ENST0000060338036185_20753539.0Zinc fingerC2H2-type 4%3B degenerate
TgeneZNF559chr19:430684chr19:9451778ENST0000060338036241_26353539.0Zinc fingerC2H2-type 5
TgeneZNF559chr19:430684chr19:9451778ENST0000060338036297_31953539.0Zinc fingerC2H2-type 6
TgeneZNF559chr19:430684chr19:9451778ENST0000060338036325_34753539.0Zinc fingerC2H2-type 7
TgeneZNF559chr19:430684chr19:9451778ENST0000060338036353_37553539.0Zinc fingerC2H2-type 8
TgeneZNF559chr19:430684chr19:9451778ENST0000060338036381_40353539.0Zinc fingerC2H2-type 9
TgeneZNF559chr19:430684chr19:9451778ENST0000060338036409_43153539.0Zinc fingerC2H2-type 10
TgeneZNF559chr19:430684chr19:9451778ENST0000060338036437_45953539.0Zinc fingerC2H2-type 11
TgeneZNF559chr19:430684chr19:9451778ENST0000060338036465_48753539.0Zinc fingerC2H2-type 12
TgeneZNF559chr19:430684chr19:9451778ENST0000060338036493_51553539.0Zinc fingerC2H2-type 13
TgeneZNF559chr19:430684chr19:9451778ENST000006033803691_11353539.0Zinc fingerC2H2-type 1%3B degenerate

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSHC2chr19:430684chr19:9451778ENST00000264554-913487_578391694.6666666666666DomainSH2
HgeneSHC2chr19:430684chr19:9451778ENST00000264554-913330_486391694.6666666666666RegionNote=CH1
TgeneZNF559chr19:430684chr19:9451778ENST000003172214714_895385.0DomainKRAB
TgeneZNF559chr19:430684chr19:9451778ENST000003938833614_8953539.0DomainKRAB
TgeneZNF559chr19:430684chr19:9451778ENST000005853523614_895385.0DomainKRAB
TgeneZNF559chr19:430684chr19:9451778ENST000006033803614_8953539.0DomainKRAB


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Fusion Gene Sequence for SHC2-ZNF559


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81651_81651_1_SHC2-ZNF559_SHC2_chr19_430684_ENST00000264554_ZNF559_chr19_9451778_ENST00000592504_length(transcript)=2157nt_BP=1174nt
ATGACGCAGGGTCCGGGCGGGCGCGCGCCCCCGGCGCCCCCCGCGCCCCCCGAGCCCGAGGCGCCCACCACCTTCTGCGCGTTGCTGCCC
CGAATGCCGCAGTGGAAGTTCGCGGCCCCGGGCGGCTTCCTGGGCCGCGGCCCGGCGGCGGCGCGGGCGGCTGGGGCCTCGGGGGGCGCG
GACCCCCAACCCGAGCCGGCGGGCCCGGGGGGCGTCCCGGCGCTGGCGGCCGCCGTCCTGGGCGCCTGCGAGCCCCGCTGCGCCGCGCCC
TGTCCCCTGCCCGCGCTCAGCCGCTGTCGGGGCGCGGGGTCGCGGGGGTCGCGGGGCGGGCGGGGGGCGGCGGGGTCCGGGGACGCCGCC
GCCGCCGCCGAGTGGATCCGGAAGGGCAGCTTCATCCACAAACCCGCGCACGGCTGGCTACACCCCGACGCCAGGGTCCTGGGGCCCGGG
GTCTCCTACGTCGTGCGGTACATGGGCTGCATCGAGGTTCTCCGCTCTATGCGCTCCCTGGACTTTAACACGCGCACGCAGGTGACCAGG
GAAGCCATCAACCGGCTCCATGAGGCCGTGCCTGGCGTCCGGGGATCCTGGAAGAAAAAGGCCCCCAACAAGGCCCTGGCGTCCGTCCTG
GGCAAGAGCAACCTTCGCTTTGCCGGCATGAGCATCTCCATCCACATCTCCACTGATGGCCTCAGCCTCTCCGTGCCTGCCACGCGCCAG
GTCATCGCCAACCACCACATGCCGTCCATCTCCTTCGCGTCAGGCGGAGACACGGACATGACGGATTACGTGGCCTACGTCGCCAAGGAC
CCCATCAACCAGAGAGCCTGCCACATCCTGGAGTGCTGTGAGGGCCTGGCACAGAGCATCATCAGCACCGTGGGCCAAGCTTTCGAGCTG
CGCTTCAAGCAGTACCTGCACAGCCCGCCCAAGGTGGCGCTGCCCCCAGAAAGGCTGGCAGGGCCGGAGGAGTCGGCCTGGGGGGACGAG
GAGGACTCTTTGGAGCACAATTACTACAACAGCATCCCGGGGAAGGAGCCGCCGCTGGGCGGGCTAGTGGACTCCAGGCTGGCCCTGACA
CAGCCCTGCGCCCTCACGGCCCTCGACCAGGGCCCATCTCCTTCTCTAAGAGATGCCTGCAGCCTGCCATGGGACGTGGGGTCCACCGGT
ACAGATTGGGAGAGTCATATTAATACCAAATGGTCAGCACCTCAGCAGAATTTTTTGCAGGGGAAAACATCCAGTGTGGTGGAAATGGTA
AGATTCAGAAGGTATAATTTATTGTCTTCCATGTTAGAGGAAGATTGGAAATTCCTTAAAATGGAAAAGCAGCACAATAACCTTGAGACA
TTTGAGACTAGTGTTTTTCACCCAAAAATAATCTGTCTCTTGGAGAGACTATGGATCATGAGTTTGACAAACACTCTAAACATCCCTCAG
AATATATTTGTTTACATATTTCCTTCAACATTCCCATATGTATCTCAGATGTTTTTGATAAATAATTCACTCTTGGGCCGTTATCAGCTA
AGCTCTATTTAGAAGCCCTCTGAAAGTAAAGAATATAACAGAACTTCCTGCAGTCACTTTGTTCCACTTGAAAACACTCAGGTCTGAACC
ATGCCTTGCAATGAAAATGGCAGGAACAAACAGTTTCAATTATACTAACTTATTTTCCATGTGTAACAGAATTCAGAGTAAAAGGGAGAA
TCTCAATGAAATAAATTTGGAAAACTTCTATGAACCATCATTAATTTTCACCAACAGGAGAGAAACCATTTTGGAGAGGAACTGTTTGAC
TTTAACCAATGTGAAAAAGCCTTGAGTGAACACTCATGCCTTAAGACTCACAGGAGAACTTACTTTAGAAAGAAAACCTGTGAGTGTAAT
CAATGTGAAAAAGCCTTCAGAAAACCCTCTATCTTTACTTTACACAAGAAAACTGATATCGGAGAGGAACTTCCTAACTGTAATCAATGT
GAAACAGCCTTCAGCCAACATCTACATCTTGTTTGCAAGAAAACTAGCCAAAATCTACATCTTGTTTGCAAGAAAACTCACACTCAAGAG

>81651_81651_1_SHC2-ZNF559_SHC2_chr19_430684_ENST00000264554_ZNF559_chr19_9451778_ENST00000592504_length(amino acids)=513AA_BP=391
MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGADPQPEPAGPGGVPALAAAVLGACEPRCAAP
CPLPALSRCRGAGSRGSRGGRGAAGSGDAAAAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTR
EAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQVIANHHMPSISFASGGDTDMTDYVAYVAKD
PINQRACHILECCEGLAQSIISTVGQAFELRFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALT
QPCALTALDQGPSPSLRDACSLPWDVGSTGTDWESHINTKWSAPQQNFLQGKTSSVVEMVRFRRYNLLSSMLEEDWKFLKMEKQHNNLET

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SHC2-ZNF559


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SHC2-ZNF559


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SHC2-ZNF559


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource