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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SHISA5-IP6K2 (FusionGDB2 ID:81694)

Fusion Gene Summary for SHISA5-IP6K2

check button Fusion gene summary
Fusion gene informationFusion gene name: SHISA5-IP6K2
Fusion gene ID: 81694
HgeneTgene
Gene symbol

SHISA5

IP6K2

Gene ID

51246

51447

Gene nameshisa family member 5inositol hexakisphosphate kinase 2
SynonymsSCOTINIHPK2|InsP6K2|PIUS
Cytomap

3p21.31

3p21.31

Type of geneprotein-codingprotein-coding
Descriptionprotein shisa-5putative NF-kappa-B-activating protein 120shisa homolog 5inositol hexakisphosphate kinase 2ATP:1D-myo-inositol-hexakisphosphate phosphotransferaseinositol hexaphosphate kinase 2insp6 kinase 2pi uptake stimulator
Modification date2020032020200327
UniProtAcc.

Q9UHH9

Ensembl transtripts involved in fusion geneENST00000296444, ENST00000442747, 
ENST00000444115, ENST00000426002, 
ENST00000443308, ENST00000465449, 
ENST00000328631, ENST00000340879, 
ENST00000413298, ENST00000417896, 
ENST00000431721, ENST00000432678, 
ENST00000436134, ENST00000443964, 
ENST00000446860, ENST00000449610, 
ENST00000450045, ENST00000453202, 
Fusion gene scores* DoF score6 X 5 X 4=12010 X 8 X 4=320
# samples 712
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/320*10)=-1.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SHISA5 [Title/Abstract] AND IP6K2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSHISA5(48538570)-IP6K2(48732851), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneIP6K2

GO:0043647

inositol phosphate metabolic process

30624931

TgeneIP6K2

GO:0046854

phosphatidylinositol phosphorylation

10574768


check buttonFusion gene breakpoints across SHISA5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across IP6K2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-VS-A8EC-01ASHISA5chr3

48538570

-IP6K2chr3

48732851

-
ChimerDB4CESCTCGA-VS-A8EC-01ASHISA5chr3

48538570

-IP6K2chr3

48732854

-
ChimerDB4CESCTCGA-VS-A8ECSHISA5chr3

48538569

-IP6K2chr3

48732851

-
ChimerDB4CESCTCGA-VS-A8ECSHISA5chr3

48538569

-IP6K2chr3

48732854

-


Top

Fusion Gene ORF analysis for SHISA5-IP6K2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000296444ENST00000328631SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000328631SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000328631SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000328631SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000340879SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000340879SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000340879SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000340879SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000413298SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000413298SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000413298SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000413298SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000417896SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000417896SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000417896SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000417896SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000431721SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000431721SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000431721SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000431721SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000432678SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000432678SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000432678SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000432678SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000436134SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000436134SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000436134SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000436134SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000443964SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000443964SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000443964SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000443964SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000446860SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000446860SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000446860SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000446860SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000449610SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000449610SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000449610SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000449610SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000450045SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000450045SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000450045SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000450045SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000453202SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000453202SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000296444ENST00000453202SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000296444ENST00000453202SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000328631SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000328631SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000328631SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000328631SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000340879SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000340879SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000340879SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000340879SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000413298SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000413298SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000413298SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000413298SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000417896SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000417896SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000417896SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000417896SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000431721SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000431721SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000431721SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000431721SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000432678SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000432678SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000432678SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000432678SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000436134SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000436134SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000436134SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000436134SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000443964SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000443964SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000443964SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000443964SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000446860SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000446860SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000446860SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000446860SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000449610SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000449610SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000449610SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000449610SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000450045SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000450045SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000450045SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000450045SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000453202SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000453202SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000442747ENST00000453202SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000442747ENST00000453202SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000328631SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000328631SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000328631SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000328631SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000340879SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000340879SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000340879SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000340879SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000413298SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000413298SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000413298SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000413298SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000417896SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000417896SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000417896SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000417896SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000431721SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000431721SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000431721SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000431721SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000432678SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000432678SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000432678SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000432678SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000436134SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000436134SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000436134SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000436134SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000443964SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000443964SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000443964SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000443964SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000446860SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000446860SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000446860SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000446860SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000449610SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000449610SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000449610SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000449610SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000450045SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000450045SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000450045SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000450045SHISA5chr3

48538569

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000453202SHISA5chr3

48538570

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000453202SHISA5chr3

48538570

-IP6K2chr3

48732854

-
5CDS-5UTRENST00000444115ENST00000453202SHISA5chr3

48538569

-IP6K2chr3

48732851

-
5CDS-5UTRENST00000444115ENST00000453202SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000328631SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000328631SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000328631SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000328631SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000340879SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000340879SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000340879SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000340879SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000413298SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000413298SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000413298SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000413298SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000417896SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000417896SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000417896SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000417896SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000431721SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000431721SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000431721SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000431721SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000432678SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000432678SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000432678SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000432678SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000436134SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000436134SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000436134SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000436134SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000443964SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000443964SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000443964SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000443964SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000446860SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000446860SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000446860SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000446860SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000449610SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000449610SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000449610SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000449610SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000450045SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000450045SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000450045SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000450045SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000453202SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000453202SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000426002ENST00000453202SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000426002ENST00000453202SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000328631SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000328631SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000328631SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000328631SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000340879SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000340879SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000340879SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000340879SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000413298SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000413298SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000413298SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000413298SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000417896SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000417896SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000417896SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000417896SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000431721SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000431721SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000431721SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000431721SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000432678SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000432678SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000432678SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000432678SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000436134SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000436134SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000436134SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000436134SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000443964SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000443964SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000443964SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000443964SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000446860SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000446860SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000446860SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000446860SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000449610SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000449610SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000449610SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000449610SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000450045SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000450045SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000450045SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000450045SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000453202SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000453202SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000443308ENST00000453202SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000443308ENST00000453202SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000328631SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000328631SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000328631SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000328631SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000340879SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000340879SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000340879SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000340879SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000413298SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000413298SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000413298SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000413298SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000417896SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000417896SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000417896SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000417896SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000431721SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000431721SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000431721SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000431721SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000432678SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000432678SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000432678SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000432678SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000436134SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000436134SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000436134SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000436134SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000443964SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000443964SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000443964SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000443964SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000446860SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000446860SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000446860SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000446860SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000449610SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000449610SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000449610SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000449610SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000450045SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000450045SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000450045SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000450045SHISA5chr3

48538569

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000453202SHISA5chr3

48538570

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000453202SHISA5chr3

48538570

-IP6K2chr3

48732854

-
intron-5UTRENST00000465449ENST00000453202SHISA5chr3

48538569

-IP6K2chr3

48732851

-
intron-5UTRENST00000465449ENST00000453202SHISA5chr3

48538569

-IP6K2chr3

48732854

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SHISA5-IP6K2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SHISA5-IP6K2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:48538570/:48732851)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.IP6K2

Q9UHH9

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). {ECO:0000269|PubMed:10574768, ECO:0000269|PubMed:30624931}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SHISA5-IP6K2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SHISA5-IP6K2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SHISA5-IP6K2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SHISA5-IP6K2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource