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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SHMT2-SLC16A7 (FusionGDB2 ID:81727)

Fusion Gene Summary for SHMT2-SLC16A7

check button Fusion gene summary
Fusion gene informationFusion gene name: SHMT2-SLC16A7
Fusion gene ID: 81727
HgeneTgene
Gene symbol

SHMT2

SLC16A7

Gene ID

6472

9194

Gene nameserine hydroxymethyltransferase 2solute carrier family 16 member 7
SynonymsGLYA|HEL-S-51e|SHMTMCT2
Cytomap

12q13.3

12q14.1

Type of geneprotein-codingprotein-coding
Descriptionserine hydroxymethyltransferase, mitochondrialGLY A+epididymis secretory sperm binding protein Li 51eglycine auxotroph A, human complement for hamsterglycine hydroxymethyltransferaseserine aldolaseserine hydroxymethylaseserine hydroxymethyltransfermonocarboxylate transporter 2solute carrier family 16 (monocarboxylate transporter), member 7solute carrier family 16, member 7 (monocarboxylic acid transporter 2)
Modification date2020032720200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000328923, ENST00000393827, 
ENST00000414700, ENST00000449049, 
ENST00000553474, ENST00000557487, 
ENST00000554600, 		ENST00000549588, 
ENST00000543448, ENST00000261187, 
ENST00000547379, ENST00000549465, 
ENST00000552024, ENST00000552432, 
Fusion gene scores* DoF score7 X 6 X 4=1689 X 8 X 7=504
# samples 812
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/504*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SHMT2 [Title/Abstract] AND SLC16A7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSHMT2(57627893)-SLC16A7(60165000), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSHMT2

GO:0006544

glycine metabolic process

25619277|29180469

HgeneSHMT2

GO:0006563

L-serine metabolic process

25619277|29180469

HgeneSHMT2

GO:0006730

one-carbon metabolic process

11516159|29180469|29364879|29452640

HgeneSHMT2

GO:0034340

response to type I interferon

24075985

HgeneSHMT2

GO:0046653

tetrahydrofolate metabolic process

24075985|25619277

HgeneSHMT2

GO:0051262

protein tetramerization

25619277

HgeneSHMT2

GO:0051289

protein homotetramerization

29180469

TgeneSLC16A7

GO:1901475

pyruvate transmembrane transport

9786900


check buttonFusion gene breakpoints across SHMT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC16A7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-GN-A26D-06ASHMT2chr12

57627893

+SLC16A7chr12

60154906

+
ChimerDB4SKCMTCGA-GN-A26D-06ASHMT2chr12

57627893

+SLC16A7chr12

60165000

+


Top

Fusion Gene ORF analysis for SHMT2-SLC16A7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000328923ENST00000549588SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-3UTRENST00000393827ENST00000549588SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-3UTRENST00000414700ENST00000549588SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-3UTRENST00000449049ENST00000549588SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-3UTRENST00000553474ENST00000549588SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-3UTRENST00000557487ENST00000549588SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-5UTRENST00000328923ENST00000543448SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-5UTRENST00000328923ENST00000543448SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-5UTRENST00000393827ENST00000543448SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-5UTRENST00000393827ENST00000543448SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-5UTRENST00000414700ENST00000543448SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-5UTRENST00000414700ENST00000543448SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-5UTRENST00000449049ENST00000543448SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-5UTRENST00000449049ENST00000543448SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-5UTRENST00000553474ENST00000543448SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-5UTRENST00000553474ENST00000543448SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-5UTRENST00000557487ENST00000543448SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-5UTRENST00000557487ENST00000543448SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000328923ENST00000261187SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000328923ENST00000261187SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000328923ENST00000547379SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000328923ENST00000549465SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000328923ENST00000549465SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000328923ENST00000549588SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000328923ENST00000552024SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000328923ENST00000552024SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000328923ENST00000552432SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000393827ENST00000261187SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000393827ENST00000261187SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000393827ENST00000547379SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000393827ENST00000549465SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000393827ENST00000549465SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000393827ENST00000549588SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000393827ENST00000552024SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000393827ENST00000552024SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000393827ENST00000552432SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000414700ENST00000261187SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000414700ENST00000261187SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000414700ENST00000547379SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000414700ENST00000549465SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000414700ENST00000549465SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000414700ENST00000549588SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000414700ENST00000552024SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000414700ENST00000552024SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000414700ENST00000552432SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000449049ENST00000261187SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000449049ENST00000261187SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000449049ENST00000547379SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000449049ENST00000549465SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000449049ENST00000549465SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000449049ENST00000549588SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000449049ENST00000552024SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000449049ENST00000552024SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000449049ENST00000552432SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000553474ENST00000261187SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000553474ENST00000261187SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000553474ENST00000547379SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000553474ENST00000549465SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000553474ENST00000549465SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000553474ENST00000549588SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000553474ENST00000552024SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000553474ENST00000552024SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000553474ENST00000552432SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000557487ENST00000261187SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000557487ENST00000261187SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000557487ENST00000547379SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000557487ENST00000549465SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000557487ENST00000549465SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000557487ENST00000549588SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000557487ENST00000552024SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
5CDS-intronENST00000557487ENST00000552024SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
5CDS-intronENST00000557487ENST00000552432SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
In-frameENST00000328923ENST00000547379SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
In-frameENST00000328923ENST00000552432SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
In-frameENST00000393827ENST00000547379SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
In-frameENST00000393827ENST00000552432SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
In-frameENST00000414700ENST00000547379SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
In-frameENST00000414700ENST00000552432SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
In-frameENST00000449049ENST00000547379SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
In-frameENST00000449049ENST00000552432SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
In-frameENST00000553474ENST00000547379SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
In-frameENST00000553474ENST00000552432SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
In-frameENST00000557487ENST00000547379SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
In-frameENST00000557487ENST00000552432SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
intron-3CDSENST00000554600ENST00000547379SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
intron-3CDSENST00000554600ENST00000552432SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
intron-3UTRENST00000554600ENST00000549588SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
intron-5UTRENST00000554600ENST00000543448SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
intron-5UTRENST00000554600ENST00000543448SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
intron-intronENST00000554600ENST00000261187SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
intron-intronENST00000554600ENST00000261187SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
intron-intronENST00000554600ENST00000547379SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
intron-intronENST00000554600ENST00000549465SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
intron-intronENST00000554600ENST00000549465SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
intron-intronENST00000554600ENST00000549588SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
intron-intronENST00000554600ENST00000552024SHMT2chr12

57627893

+SLC16A7chr12

60154906

+
intron-intronENST00000554600ENST00000552024SHMT2chr12

57627893

+SLC16A7chr12

60165000

+
intron-intronENST00000554600ENST00000552432SHMT2chr12

57627893

+SLC16A7chr12

60154906

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000328923SHMT2chr1257627893+ENST00000552432SLC16A7chr1260165000+359318394523058868
ENST00000328923SHMT2chr1257627893+ENST00000547379SLC16A7chr1260165000+336918394523058868
ENST00000557487SHMT2chr1257627893+ENST00000552432SLC16A7chr1260165000+31791425682644858
ENST00000557487SHMT2chr1257627893+ENST00000547379SLC16A7chr1260165000+29551425682644858
ENST00000414700SHMT2chr1257627893+ENST00000552432SLC16A7chr1260165000+326715131022732876
ENST00000414700SHMT2chr1257627893+ENST00000547379SLC16A7chr1260165000+304315131022732876
ENST00000553474SHMT2chr1257627893+ENST00000552432SLC16A7chr1260165000+32011447332666877
ENST00000553474SHMT2chr1257627893+ENST00000547379SLC16A7chr1260165000+29771447332666877
ENST00000449049SHMT2chr1257627893+ENST00000552432SLC16A7chr1260165000+340916552952874859
ENST00000449049SHMT2chr1257627893+ENST00000547379SLC16A7chr1260165000+318516552952874859
ENST00000393827SHMT2chr1257627893+ENST00000552432SLC16A7chr1260165000+310913552562574772
ENST00000393827SHMT2chr1257627893+ENST00000547379SLC16A7chr1260165000+288513552562574772

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000328923ENST00000552432SHMT2chr1257627893+SLC16A7chr1260165000+0.0002479760.999752
ENST00000328923ENST00000547379SHMT2chr1257627893+SLC16A7chr1260165000+0.0003753460.9996246
ENST00000557487ENST00000552432SHMT2chr1257627893+SLC16A7chr1260165000+0.000336370.9996636
ENST00000557487ENST00000547379SHMT2chr1257627893+SLC16A7chr1260165000+0.000538270.9994617
ENST00000414700ENST00000552432SHMT2chr1257627893+SLC16A7chr1260165000+0.0005441070.99945587
ENST00000414700ENST00000547379SHMT2chr1257627893+SLC16A7chr1260165000+0.0008625170.9991374
ENST00000553474ENST00000552432SHMT2chr1257627893+SLC16A7chr1260165000+0.0004614450.99953854
ENST00000553474ENST00000547379SHMT2chr1257627893+SLC16A7chr1260165000+0.0007298610.99927014
ENST00000449049ENST00000552432SHMT2chr1257627893+SLC16A7chr1260165000+0.0005249870.99947506
ENST00000449049ENST00000547379SHMT2chr1257627893+SLC16A7chr1260165000+0.000824760.99917525
ENST00000393827ENST00000552432SHMT2chr1257627893+SLC16A7chr1260165000+0.0010475530.9989524
ENST00000393827ENST00000547379SHMT2chr1257627893+SLC16A7chr1260165000+0.0014758050.99852425

Top

Fusion Genomic Features for SHMT2-SLC16A7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SHMT2chr1257627893+SLC16A7chr1260154905+0.124156980.875843
SHMT2chr1257627893+SLC16A7chr1260164999+0.0057635490.9942365
SHMT2chr1257627893+SLC16A7chr1260154905+0.124156980.875843
SHMT2chr1257627893+SLC16A7chr1260164999+0.0057635490.9942365

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SHMT2-SLC16A7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:57627893/chr12:60165000)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715111_11572479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715137_14872479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715170_17372479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715195_24672479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715268_28272479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715304_31272479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715334_33872479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715360_37372479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715395_40672479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715428_47872479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST000002611871581_8972479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926111_11572479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926137_14872479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926170_17372479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926195_24672479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926268_28272479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926304_31272479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926334_33872479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926360_37372479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926395_40672479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926428_47872479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST000005473792681_8972479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437111_11572479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437137_14872479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437170_17372479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437195_24672479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437268_28272479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437304_31272479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437334_33872479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437360_37372479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437395_40672479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437428_47872479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST000005520243781_8972479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226111_11572479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226137_14872479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226170_17372479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226195_24672479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226268_28272479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226304_31272479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226334_33872479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226360_37372479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226395_40672479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226428_47872479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST000005524322681_8972479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715116_13672479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715149_16972479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715174_19472479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715247_26772479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715283_30372479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715313_33372479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715339_35972479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715374_39472479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000026118715407_42772479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST000002611871590_11072479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926116_13672479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926149_16972479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926174_19472479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926247_26772479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926283_30372479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926313_33372479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926339_35972479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926374_39472479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000054737926407_42772479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST000005473792690_11072479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437116_13672479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437149_16972479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437174_19472479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437247_26772479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437283_30372479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437313_33372479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437339_35972479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437374_39472479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055202437407_42772479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST000005520243790_11072479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226116_13672479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226149_16972479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226174_19472479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226247_26772479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226283_30372479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226313_33372479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226339_35972479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226374_39472479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST0000055243226407_42772479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST000005524322690_11072479.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC16A7chr12:57627893chr12:60165000ENST00000261187151_1572479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST000002611871537_5972479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST00000547379261_1572479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST000005473792637_5972479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST00000552024371_1572479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST000005520243737_5972479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST00000552432261_1572479.0Topological domainCytoplasmic
TgeneSLC16A7chr12:57627893chr12:60165000ENST000005524322637_5972479.0Topological domainExtracellular
TgeneSLC16A7chr12:57627893chr12:60165000ENST000002611871516_3672479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST000002611871560_8072479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST000005473792616_3672479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST000005473792660_8072479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST000005520243716_3672479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST000005520243760_8072479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST000005524322616_3672479.0TransmembraneHelical
TgeneSLC16A7chr12:57627893chr12:60165000ENST000005524322660_8072479.0TransmembraneHelical


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Fusion Gene Sequence for SHMT2-SLC16A7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81727_81727_1_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000328923_SLC16A7_chr12_60165000_ENST00000547379_length(transcript)=3369nt_BP=1839nt
ACGGTGCTTTCCAGTGTTCCATAGCTCTTTATCTTGTGTGGGGGTCTAGATCTCCTGGAGTCTAATAATGCTAGCTAGATATTCAGTAGG
CACCCTATAAACGTTTGTCTTGACAACAAGCAGAGAGAAAACCCTGAAAAGCTTCAAGATAGTAAGGAGAGGGGGCGGCACTGGACCTCT
GTTTTTGTTTTTTGTTTTTTTCCCCCCAGGCAAGGGCCTCTAACCCTGGGGCTACAGACGGGAATCATAAAGAAAAAAGCGGTGAGTGGG
CGAACTACAATTCCCAAAAGGCCACAAAGGGGCCACCACTACGCATGCGTAGATCCCTCCCGTTAGCTTTGGCGCCTCAGCGAGCTCTTC
TCGCGCATGCGTTCTCCGAACGGTCTTCTTCCGACAGCTTGCTGCCCTAGACCAGAGTTGGTGGCTGGACCTCCTGCGACTTCCGAGTTG
CGATGCTGTACTTCTCTTTGTTTTGGGCGGCTCGGCCTCTGCAGAGATGTGGGCAGCTGGTCAGGATGGCCATTCGGGCTCAGCACAGCA
ACGCAGCCCAGACTCAGACTGGGGAAGCAAACAGGGGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATCCTGAGATGTGGGAGTTGC
TGCAGAGGGAGAAGGACAGGCAGTGTCGTGGCCTGGAGCTCATTGCCTCAGAGAACTTCTGCAGCCGAGCTGCGCTGGAGGCCCTGGGGT
CCTGTCTGAACAACAAGTACTCGGAGGGTTATCCTGGCAAGAGATACTATGGGGGAGCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCC
AGCGCCGGGCCTTGGAAGCCTTTGACCTGGATCCTGCACAGTGGGGAGTCAATGTCCAGCCCTACTCCGGGTCCCCAGCCAACCTGGCCG
TCTACACAGCCCTTCTGCAACCTCACGACCGGATCATGGGGCTGGACCTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGACG
TCAAGCGGATATCAGCCACGTCCATCTTCTTCGAGTCTATGCCCTATAAGCTCAACCCCAAAACTGGCCTCATTGACTACAACCAGCTGG
CACTGACTGCTCGACTTTTCCGGCCACGGCTCATCATAGCTGGCACCAGCGCCTATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGG
TGTGTGATGAAGTCAAAGCACACCTGCTGGCAGACATGGCCCACATCAGTGGCCTGGTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGC
ACGCGGACATCGTCACCACCACTACTCACAAGACTCTTCGAGGGGCCAGGTCAGGGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGG
ACCCCAAGACTGGCCGGGAGATCCCTTACACATTTGAGGACCGAATCAACTTTGCCGTGTTCCCATCCCTGCAGGGGGGCCCCCACAATC
ATGCCATTGCTGCAGTAGCTGTGGCCCTAAAGCAGGCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGG
CCATGGCAGATGCCCTGCTAGAGCGAGGCTACTCACTGGTATCAGGTGGTACTGACAACCACCTGGTGCTGGTGGACCTGCGGCCCAAGG
GCCTGGATGGAGCTCGGGCTGAGCGGGTGCTAGAGCTTGTATCCATCACTGCCAACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCA
CACCGGGCGGCCTGCGGCTTGGGGCCCCAGCCTTAACTTCTCGACAGTTCCGTGAGGATGACTTCCGGAGAGTTGTGGACTTTATAGATG
AAGGGGTCAACATTGGCTTAGAGGTGAAGAGCAAGACTGGTCCTGTAAGTAGTGTTTTGGTGAATAAATACGGCAGCCGGCCGGTGGTGA
TAGCAGGAGGCTTATTATGCTGTCTTGGAATGGTGTTGGCCTCCTTTAGTAGCAGCGTGGTACAGCTGTACCTCACTATGGGATTCATTA
CAGGTTTAGGTTTAGCCTTCAACCTGCAACCCGCCTTAACCATAATTGGCAAATACTTCTATAGGAAGCGACCCATGGCAAATGGATTGG
CCATGGCAGGAAGTCCTGTTTTCTTAAGTTCATTGGCTCCTTTCAATCAGTACCTTTTTAATACTTTTGGCTGGAAAGGAAGCTTCCTGA
TTTTGGGAAGTCTACTTTTGAATGCCTGTGTGGCTGGTTCCCTCATGAGACCCCTTGGACCCAATCAAACCACTTCTAAGTCTAAAAATA
AGACTGGCAAAACAGAAGATGATTCAAGCCCAAAGAAAATCAAAACGAAGAAATCAACTTGGGAAAAAGTTAATAAGTATTTAGATTTCT
CCCTTTTTAAGCATAGAGGATTTCTGATATATCTGTCTGGAAATGTCATTATGTTCCTAGGTTTTTTTGCCCCCATTATATTCTTGGCTC
CATATGCTAAAGACCAAGGAATTGATGAGTACTCGGCAGCTTTTCTGCTATCTGTTATGGCTTTCGTTGATATGTTTGCTAGGCCTTCTG
TAGGATTAATTGCAAACTCCAAATATATTCGACCTCGAATTCAGTACTTCTTCAGTTTTGCAATCATGTTCAATGGAGTGTGTCACCTCT
TGTGCCCACTGGCACAGGACTACACAAGCCTGGTATTATATGCTGTATTTTTTGGCCTTGGATTTGGGAGTGTTAGCAGTGTTCTCTTTG
AAACTCTCATGGACCTCGTGGGTGCACCAAGATTTTCCAGTGCCGTCGGACTTGTCACAATTGTGGAGTGTGGCCCAGTTCTTCTTGGCC
CTCCTCTTGCAGGTAAATTGGTGGATTTAACTGGAGAATATAAATACATGTACATGTCCTGTGGGGCTATTGTGGTAGCAGCAAGCGTGT
GGCTGCTCATTGGCAATGCTATCAACTATAGATTGCTTGCAAAGGAAAGGAAGGAGGAAAATGCAAGGCAGAAGACCAGAGAATCTGAAC
CCTTGAGCAAATCTAAACATTCGGAAGATGTTAACGTCAAAGTTTCAAATGCACAGAGTGTAACCTCAGAAAGAGAAACTAACATTTAAC
AAGAATCACATCTCTGATTTCAGTGTTTATGACTTTATCTAGGAGTTTGTTTTTCATTTTGTTTTTTTAAAGTATTAGAAAAGGTTTTAG
CTGAAATGAGGAGTCACAATTAAGGATGGAGGTGATATTTTCCTCAATGGCAAATTTTAAATTAGTTTTTAAAAACTTACTTATTTGGGT
AGTTAAATTTTGAGATTATGCATAGAAAGAATCCATGCTATAGGTTTATTTCCATACCTGACTCTGGGTGTGGTGGTTAAAATACTAATT

>81727_81727_1_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000328923_SLC16A7_chr12_60165000_ENST00000547379_length(amino acids)=868AA_BP=462
MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGS
CLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV
KRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKH
ADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA
MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDE
GVNIGLEVKSKTGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLA
MAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFS
LFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLL
CPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVW

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>81727_81727_2_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000328923_SLC16A7_chr12_60165000_ENST00000552432_length(transcript)=3593nt_BP=1839nt
ACGGTGCTTTCCAGTGTTCCATAGCTCTTTATCTTGTGTGGGGGTCTAGATCTCCTGGAGTCTAATAATGCTAGCTAGATATTCAGTAGG
CACCCTATAAACGTTTGTCTTGACAACAAGCAGAGAGAAAACCCTGAAAAGCTTCAAGATAGTAAGGAGAGGGGGCGGCACTGGACCTCT
GTTTTTGTTTTTTGTTTTTTTCCCCCCAGGCAAGGGCCTCTAACCCTGGGGCTACAGACGGGAATCATAAAGAAAAAAGCGGTGAGTGGG
CGAACTACAATTCCCAAAAGGCCACAAAGGGGCCACCACTACGCATGCGTAGATCCCTCCCGTTAGCTTTGGCGCCTCAGCGAGCTCTTC
TCGCGCATGCGTTCTCCGAACGGTCTTCTTCCGACAGCTTGCTGCCCTAGACCAGAGTTGGTGGCTGGACCTCCTGCGACTTCCGAGTTG
CGATGCTGTACTTCTCTTTGTTTTGGGCGGCTCGGCCTCTGCAGAGATGTGGGCAGCTGGTCAGGATGGCCATTCGGGCTCAGCACAGCA
ACGCAGCCCAGACTCAGACTGGGGAAGCAAACAGGGGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATCCTGAGATGTGGGAGTTGC
TGCAGAGGGAGAAGGACAGGCAGTGTCGTGGCCTGGAGCTCATTGCCTCAGAGAACTTCTGCAGCCGAGCTGCGCTGGAGGCCCTGGGGT
CCTGTCTGAACAACAAGTACTCGGAGGGTTATCCTGGCAAGAGATACTATGGGGGAGCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCC
AGCGCCGGGCCTTGGAAGCCTTTGACCTGGATCCTGCACAGTGGGGAGTCAATGTCCAGCCCTACTCCGGGTCCCCAGCCAACCTGGCCG
TCTACACAGCCCTTCTGCAACCTCACGACCGGATCATGGGGCTGGACCTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGACG
TCAAGCGGATATCAGCCACGTCCATCTTCTTCGAGTCTATGCCCTATAAGCTCAACCCCAAAACTGGCCTCATTGACTACAACCAGCTGG
CACTGACTGCTCGACTTTTCCGGCCACGGCTCATCATAGCTGGCACCAGCGCCTATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGG
TGTGTGATGAAGTCAAAGCACACCTGCTGGCAGACATGGCCCACATCAGTGGCCTGGTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGC
ACGCGGACATCGTCACCACCACTACTCACAAGACTCTTCGAGGGGCCAGGTCAGGGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGG
ACCCCAAGACTGGCCGGGAGATCCCTTACACATTTGAGGACCGAATCAACTTTGCCGTGTTCCCATCCCTGCAGGGGGGCCCCCACAATC
ATGCCATTGCTGCAGTAGCTGTGGCCCTAAAGCAGGCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGG
CCATGGCAGATGCCCTGCTAGAGCGAGGCTACTCACTGGTATCAGGTGGTACTGACAACCACCTGGTGCTGGTGGACCTGCGGCCCAAGG
GCCTGGATGGAGCTCGGGCTGAGCGGGTGCTAGAGCTTGTATCCATCACTGCCAACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCA
CACCGGGCGGCCTGCGGCTTGGGGCCCCAGCCTTAACTTCTCGACAGTTCCGTGAGGATGACTTCCGGAGAGTTGTGGACTTTATAGATG
AAGGGGTCAACATTGGCTTAGAGGTGAAGAGCAAGACTGGTCCTGTAAGTAGTGTTTTGGTGAATAAATACGGCAGCCGGCCGGTGGTGA
TAGCAGGAGGCTTATTATGCTGTCTTGGAATGGTGTTGGCCTCCTTTAGTAGCAGCGTGGTACAGCTGTACCTCACTATGGGATTCATTA
CAGGTTTAGGTTTAGCCTTCAACCTGCAACCCGCCTTAACCATAATTGGCAAATACTTCTATAGGAAGCGACCCATGGCAAATGGATTGG
CCATGGCAGGAAGTCCTGTTTTCTTAAGTTCATTGGCTCCTTTCAATCAGTACCTTTTTAATACTTTTGGCTGGAAAGGAAGCTTCCTGA
TTTTGGGAAGTCTACTTTTGAATGCCTGTGTGGCTGGTTCCCTCATGAGACCCCTTGGACCCAATCAAACCACTTCTAAGTCTAAAAATA
AGACTGGCAAAACAGAAGATGATTCAAGCCCAAAGAAAATCAAAACGAAGAAATCAACTTGGGAAAAAGTTAATAAGTATTTAGATTTCT
CCCTTTTTAAGCATAGAGGATTTCTGATATATCTGTCTGGAAATGTCATTATGTTCCTAGGTTTTTTTGCCCCCATTATATTCTTGGCTC
CATATGCTAAAGACCAAGGAATTGATGAGTACTCGGCAGCTTTTCTGCTATCTGTTATGGCTTTCGTTGATATGTTTGCTAGGCCTTCTG
TAGGATTAATTGCAAACTCCAAATATATTCGACCTCGAATTCAGTACTTCTTCAGTTTTGCAATCATGTTCAATGGAGTGTGTCACCTCT
TGTGCCCACTGGCACAGGACTACACAAGCCTGGTATTATATGCTGTATTTTTTGGCCTTGGATTTGGGAGTGTTAGCAGTGTTCTCTTTG
AAACTCTCATGGACCTCGTGGGTGCACCAAGATTTTCCAGTGCCGTCGGACTTGTCACAATTGTGGAGTGTGGCCCAGTTCTTCTTGGCC
CTCCTCTTGCAGGTAAATTGGTGGATTTAACTGGAGAATATAAATACATGTACATGTCCTGTGGGGCTATTGTGGTAGCAGCAAGCGTGT
GGCTGCTCATTGGCAATGCTATCAACTATAGATTGCTTGCAAAGGAAAGGAAGGAGGAAAATGCAAGGCAGAAGACCAGAGAATCTGAAC
CCTTGAGCAAATCTAAACATTCGGAAGATGTTAACGTCAAAGTTTCAAATGCACAGAGTGTAACCTCAGAAAGAGAAACTAACATTTAAC
AAGAATCACATCTCTGATTTCAGTGTTTATGACTTTATCTAGGAGTTTGTTTTTCATTTTGTTTTTTTAAAGTATTAGAAAAGGTTTTAG
CTGAAATGAGGAGTCACAATTAAGGATGGAGGTGATATTTTCCTCAATGGCAAATTTTAAATTAGTTTTTAAAAACTTACTTATTTGGGT
AGTTAAATTTTGAGATTATGCATAGAAAGAATCCATGCTATAGGTTTATTTCCATACCTGACTCTGGGTGTGGTGGTTAAAATACTAATT
TTAAAGTCTTCCAGTGACTTTCGGTCTTGGTTATATGGAGAATTCTGAATCCCAAACCCCTGGTTTAAGTAGGTAGAAGGAGGATGCCTA
ATCCTACAAAGTGACCCTTTATACATTTCATTTTTTATTTGATATTAAAGTATGAGATAGAGTTGAGAGACAATTAATTATCCCCTCTTA

>81727_81727_2_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000328923_SLC16A7_chr12_60165000_ENST00000552432_length(amino acids)=868AA_BP=462
MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGS
CLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV
KRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKH
ADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA
MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDE
GVNIGLEVKSKTGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLA
MAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFS
LFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLL
CPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVW

--------------------------------------------------------------
>81727_81727_3_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000393827_SLC16A7_chr12_60165000_ENST00000547379_length(transcript)=2885nt_BP=1355nt
ACAATCTGTGGCCTCAGCCCTTGCCAACTCTGCCTCTTCCCCCGCTGACTGGGCCTCTGCAGAGATGTGGGCAGCTGGTCAGGATGGCCA
TTCGGGCTCAGCACAGCAACGCAGCCCAGACTCAGACTGGGGAAGCAAACAGGGGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATC
CTGAGATGTGGGAGTTGCTGCAGAGGGAGAAGGACAGGCAGTGTCGTGGCCTGGAGCTCATTGCCTCAGAGATACTATGGGGGAGCAGAG
GTGGTGGATGAAATTGAGCTGCTGTGCCAGCGCCGGGCCTTGGAAGCCTTTGACCTGGATCCTGCACAGTGGGGAGTCAATGTCCAGCCC
TACTCCGGGTCCCCAGCCAACCTGGCCGTCTACACAGCCCTTCTGCAACCTCACGACCGGATCATGGGGCTGGACCTGCCCGATGGGGGC
CATCTCACCCACGGCTACATGTCTGACGTCAAGCGGATATCAGCCACGTCCATCTTCTTCGAGTCTATGCCCTATAAGCTCAACGGCTTT
AGCTGTTTGTGTGTCTGTCCAGCCCAAAACTGGCCTCATTGACTACAACCAGCTGGCACTGACTGCTCGACTTTTCCGGCCACGGCTCAT
CATAGCTGGCACCAGCGCCTATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTGTGATGAAGTCAAAGCACACCTGCTGGCAGA
CATGGCCCACATCAGTGGCCTGGTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGCACGCGGACATCGTCACCACCACTACTCACAAGAC
TCTTCGAGGGGCCAGGTCAGGGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCCCAAGACTGGCCGGGAGATCCCTTACACATT
TGAGGACCGAATCAACTTTGCCGTGTTCCCATCCCTGCAGGGGGGCCCCCACAATCATGCCATTGCTGCAGTAGCTGTGGCCCTAAAGCA
GGCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCATGGCAGATGCCCTGCTAGAGCGAGGCTACTC
ACTGGTATCAGGTGGTACTGACAACCACCTGGTGCTGGTGGACCTGCGGCCCAAGGGCCTGGATGGAGCTCGGGCTGAGCGGGTGCTAGA
GCTTGTATCCATCACTGCCAACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACCGGGCGGCCTGCGGCTTGGGGCCCCAGCCTT
AACTTCTCGACAGTTCCGTGAGGATGACTTCCGGAGAGTTGTGGACTTTATAGATGAAGGGGTCAACATTGGCTTAGAGGTGAAGAGCAA
GACTGGTCCTGTAAGTAGTGTTTTGGTGAATAAATACGGCAGCCGGCCGGTGGTGATAGCAGGAGGCTTATTATGCTGTCTTGGAATGGT
GTTGGCCTCCTTTAGTAGCAGCGTGGTACAGCTGTACCTCACTATGGGATTCATTACAGGTTTAGGTTTAGCCTTCAACCTGCAACCCGC
CTTAACCATAATTGGCAAATACTTCTATAGGAAGCGACCCATGGCAAATGGATTGGCCATGGCAGGAAGTCCTGTTTTCTTAAGTTCATT
GGCTCCTTTCAATCAGTACCTTTTTAATACTTTTGGCTGGAAAGGAAGCTTCCTGATTTTGGGAAGTCTACTTTTGAATGCCTGTGTGGC
TGGTTCCCTCATGAGACCCCTTGGACCCAATCAAACCACTTCTAAGTCTAAAAATAAGACTGGCAAAACAGAAGATGATTCAAGCCCAAA
GAAAATCAAAACGAAGAAATCAACTTGGGAAAAAGTTAATAAGTATTTAGATTTCTCCCTTTTTAAGCATAGAGGATTTCTGATATATCT
GTCTGGAAATGTCATTATGTTCCTAGGTTTTTTTGCCCCCATTATATTCTTGGCTCCATATGCTAAAGACCAAGGAATTGATGAGTACTC
GGCAGCTTTTCTGCTATCTGTTATGGCTTTCGTTGATATGTTTGCTAGGCCTTCTGTAGGATTAATTGCAAACTCCAAATATATTCGACC
TCGAATTCAGTACTTCTTCAGTTTTGCAATCATGTTCAATGGAGTGTGTCACCTCTTGTGCCCACTGGCACAGGACTACACAAGCCTGGT
ATTATATGCTGTATTTTTTGGCCTTGGATTTGGGAGTGTTAGCAGTGTTCTCTTTGAAACTCTCATGGACCTCGTGGGTGCACCAAGATT
TTCCAGTGCCGTCGGACTTGTCACAATTGTGGAGTGTGGCCCAGTTCTTCTTGGCCCTCCTCTTGCAGGTAAATTGGTGGATTTAACTGG
AGAATATAAATACATGTACATGTCCTGTGGGGCTATTGTGGTAGCAGCAAGCGTGTGGCTGCTCATTGGCAATGCTATCAACTATAGATT
GCTTGCAAAGGAAAGGAAGGAGGAAAATGCAAGGCAGAAGACCAGAGAATCTGAACCCTTGAGCAAATCTAAACATTCGGAAGATGTTAA
CGTCAAAGTTTCAAATGCACAGAGTGTAACCTCAGAAAGAGAAACTAACATTTAACAAGAATCACATCTCTGATTTCAGTGTTTATGACT
TTATCTAGGAGTTTGTTTTTCATTTTGTTTTTTTAAAGTATTAGAAAAGGTTTTAGCTGAAATGAGGAGTCACAATTAAGGATGGAGGTG
ATATTTTCCTCAATGGCAAATTTTAAATTAGTTTTTAAAAACTTACTTATTTGGGTAGTTAAATTTTGAGATTATGCATAGAAAGAATCC
ATGCTATAGGTTTATTTCCATACCTGACTCTGGGTGTGGTGGTTAAAATACTAATTTTAAAGTCTTCCAGTGACTTTCGGTCTTGGTTAT

>81727_81727_3_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000393827_SLC16A7_chr12_60165000_ENST00000547379_length(amino acids)=772AA_BP=366
MGEQRWWMKLSCCASAGPWKPLTWILHSGESMSSPTPGPQPTWPSTQPFCNLTTGSWGWTCPMGAISPTATCLTSSGYQPRPSSSSLCPI
SSTALAVCVSVQPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTT
TTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALL
ERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGL
EVKSKTGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPV
FLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRG
FLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQD
YTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNA

--------------------------------------------------------------
>81727_81727_4_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000393827_SLC16A7_chr12_60165000_ENST00000552432_length(transcript)=3109nt_BP=1355nt
ACAATCTGTGGCCTCAGCCCTTGCCAACTCTGCCTCTTCCCCCGCTGACTGGGCCTCTGCAGAGATGTGGGCAGCTGGTCAGGATGGCCA
TTCGGGCTCAGCACAGCAACGCAGCCCAGACTCAGACTGGGGAAGCAAACAGGGGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATC
CTGAGATGTGGGAGTTGCTGCAGAGGGAGAAGGACAGGCAGTGTCGTGGCCTGGAGCTCATTGCCTCAGAGATACTATGGGGGAGCAGAG
GTGGTGGATGAAATTGAGCTGCTGTGCCAGCGCCGGGCCTTGGAAGCCTTTGACCTGGATCCTGCACAGTGGGGAGTCAATGTCCAGCCC
TACTCCGGGTCCCCAGCCAACCTGGCCGTCTACACAGCCCTTCTGCAACCTCACGACCGGATCATGGGGCTGGACCTGCCCGATGGGGGC
CATCTCACCCACGGCTACATGTCTGACGTCAAGCGGATATCAGCCACGTCCATCTTCTTCGAGTCTATGCCCTATAAGCTCAACGGCTTT
AGCTGTTTGTGTGTCTGTCCAGCCCAAAACTGGCCTCATTGACTACAACCAGCTGGCACTGACTGCTCGACTTTTCCGGCCACGGCTCAT
CATAGCTGGCACCAGCGCCTATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTGTGATGAAGTCAAAGCACACCTGCTGGCAGA
CATGGCCCACATCAGTGGCCTGGTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGCACGCGGACATCGTCACCACCACTACTCACAAGAC
TCTTCGAGGGGCCAGGTCAGGGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCCCAAGACTGGCCGGGAGATCCCTTACACATT
TGAGGACCGAATCAACTTTGCCGTGTTCCCATCCCTGCAGGGGGGCCCCCACAATCATGCCATTGCTGCAGTAGCTGTGGCCCTAAAGCA
GGCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCATGGCAGATGCCCTGCTAGAGCGAGGCTACTC
ACTGGTATCAGGTGGTACTGACAACCACCTGGTGCTGGTGGACCTGCGGCCCAAGGGCCTGGATGGAGCTCGGGCTGAGCGGGTGCTAGA
GCTTGTATCCATCACTGCCAACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACCGGGCGGCCTGCGGCTTGGGGCCCCAGCCTT
AACTTCTCGACAGTTCCGTGAGGATGACTTCCGGAGAGTTGTGGACTTTATAGATGAAGGGGTCAACATTGGCTTAGAGGTGAAGAGCAA
GACTGGTCCTGTAAGTAGTGTTTTGGTGAATAAATACGGCAGCCGGCCGGTGGTGATAGCAGGAGGCTTATTATGCTGTCTTGGAATGGT
GTTGGCCTCCTTTAGTAGCAGCGTGGTACAGCTGTACCTCACTATGGGATTCATTACAGGTTTAGGTTTAGCCTTCAACCTGCAACCCGC
CTTAACCATAATTGGCAAATACTTCTATAGGAAGCGACCCATGGCAAATGGATTGGCCATGGCAGGAAGTCCTGTTTTCTTAAGTTCATT
GGCTCCTTTCAATCAGTACCTTTTTAATACTTTTGGCTGGAAAGGAAGCTTCCTGATTTTGGGAAGTCTACTTTTGAATGCCTGTGTGGC
TGGTTCCCTCATGAGACCCCTTGGACCCAATCAAACCACTTCTAAGTCTAAAAATAAGACTGGCAAAACAGAAGATGATTCAAGCCCAAA
GAAAATCAAAACGAAGAAATCAACTTGGGAAAAAGTTAATAAGTATTTAGATTTCTCCCTTTTTAAGCATAGAGGATTTCTGATATATCT
GTCTGGAAATGTCATTATGTTCCTAGGTTTTTTTGCCCCCATTATATTCTTGGCTCCATATGCTAAAGACCAAGGAATTGATGAGTACTC
GGCAGCTTTTCTGCTATCTGTTATGGCTTTCGTTGATATGTTTGCTAGGCCTTCTGTAGGATTAATTGCAAACTCCAAATATATTCGACC
TCGAATTCAGTACTTCTTCAGTTTTGCAATCATGTTCAATGGAGTGTGTCACCTCTTGTGCCCACTGGCACAGGACTACACAAGCCTGGT
ATTATATGCTGTATTTTTTGGCCTTGGATTTGGGAGTGTTAGCAGTGTTCTCTTTGAAACTCTCATGGACCTCGTGGGTGCACCAAGATT
TTCCAGTGCCGTCGGACTTGTCACAATTGTGGAGTGTGGCCCAGTTCTTCTTGGCCCTCCTCTTGCAGGTAAATTGGTGGATTTAACTGG
AGAATATAAATACATGTACATGTCCTGTGGGGCTATTGTGGTAGCAGCAAGCGTGTGGCTGCTCATTGGCAATGCTATCAACTATAGATT
GCTTGCAAAGGAAAGGAAGGAGGAAAATGCAAGGCAGAAGACCAGAGAATCTGAACCCTTGAGCAAATCTAAACATTCGGAAGATGTTAA
CGTCAAAGTTTCAAATGCACAGAGTGTAACCTCAGAAAGAGAAACTAACATTTAACAAGAATCACATCTCTGATTTCAGTGTTTATGACT
TTATCTAGGAGTTTGTTTTTCATTTTGTTTTTTTAAAGTATTAGAAAAGGTTTTAGCTGAAATGAGGAGTCACAATTAAGGATGGAGGTG
ATATTTTCCTCAATGGCAAATTTTAAATTAGTTTTTAAAAACTTACTTATTTGGGTAGTTAAATTTTGAGATTATGCATAGAAAGAATCC
ATGCTATAGGTTTATTTCCATACCTGACTCTGGGTGTGGTGGTTAAAATACTAATTTTAAAGTCTTCCAGTGACTTTCGGTCTTGGTTAT
ATGGAGAATTCTGAATCCCAAACCCCTGGTTTAAGTAGGTAGAAGGAGGATGCCTAATCCTACAAAGTGACCCTTTATACATTTCATTTT
TTATTTGATATTAAAGTATGAGATAGAGTTGAGAGACAATTAATTATCCCCTCTTACACACAAACACACATACTCCCACATACTTACCCA

>81727_81727_4_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000393827_SLC16A7_chr12_60165000_ENST00000552432_length(amino acids)=772AA_BP=366
MGEQRWWMKLSCCASAGPWKPLTWILHSGESMSSPTPGPQPTWPSTQPFCNLTTGSWGWTCPMGAISPTATCLTSSGYQPRPSSSSLCPI
SSTALAVCVSVQPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTT
TTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALL
ERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGL
EVKSKTGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPV
FLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRG
FLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQD
YTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNA

--------------------------------------------------------------
>81727_81727_5_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000414700_SLC16A7_chr12_60165000_ENST00000547379_length(transcript)=3043nt_BP=1513nt
GCGGACCCGGTGCTGGCAAATGAGCGGAGTTTTCGGCCTGGTCTCACAAGCTGAGCCTTTCCGGCCAGCTCTGAGCCCTGCAGATGATGC
AACCGAGCTTCACTGCTTGCATCAGGCAGGGGTCCCGGCGGCAGTGAGGGCTGGAAGGAGGTGGAACGGCCTCTGCAGAGATGTGGGCAG
CTGGTCAGGATGGCCATTCGGGCTCAGCACAGCAACGCAGCCCAGACTCAGACTGGGGAAGCAAACAGGGGCTGGACAGGCCAGGAGAGC
CTGTCGGACAGTGATCCTGAGATGTGGGAGTTGCTGCAGAGGGAGAAGGACAGGCAGTGTCGTGGCCTGGAGCTCATTGCCTCAGAGAAC
TTCTGCAGCCGAGCTGCGCTGGAGGCCCTGGGGTCCTGTCTGAACAACAAGTACTCGGAGGGTTATCCTGGCAAGAGATACTATGGGGGA
GCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCCAGCGCCGGGCCTTGGAAGCCTTTGACCTGGATCCTGCACAGTGGGGAGTCAATGTC
CAGCCCTACTCCGGGTCCCCAGCCAACCTGGCCGTCTACACAGCCCTTCTGCAACCTCACGACCGGATCATGGGGCTGGACCTGCCCGAT
GGGGGCCATCTCACCCACGGCTACATGTCTGACGTCAAGCGGATATCAGCCACGTCCATCTTCTTCGAGTCTATGCCCTATAAGCTCAAC
CCCAAAACTGGCCTCATTGACTACAACCAGCTGGCACTGACTGCTCGACTTTTCCGGCCACGGCTCATCATAGCTGGCACCAGCGCCTAT
GCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTGTGATGAAGTCAAAGCACACCTGCTGGCAGACATGGCCCACATCAGTGGCCTG
GTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGCACGCGGACATCGTCACCACCACTACTCACAAGACTCTTCGAGGGGCCAGGTCAGGG
CTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCCCAAGACTGGCCGGGAGATCCCTTACACATTTGAGGACCGAATCAACTTTGCC
GTGTTCCCATCCCTGCAGGGGGGCCCCCACAATCATGCCATTGCTGCAGTAGCTGTGGCCCTAAAGCAGGCCTGCACCCCCATGTTCCGG
GAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCATGGCAGATGCCCTGCTAGAGCGAGGCTACTCACTGGTATCAGGTGGTACTGAC
AACCACCTGGTGCTGGTGGACCTGCGGCCCAAGGGCCTGGATGGAGCTCGGGCTGAGCGGGTGCTAGAGCTTGTATCCATCACTGCCAAC
AAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACCGGGCGGCCTGCGGCTTGGGGCCCCAGCCTTAACTTCTCGACAGTTCCGTGAG
GATGACTTCCGGAGAGTTGTGGACTTTATAGATGAAGGGGTCAACATTGGCTTAGAGGTGAAGAGCAAGACTGGTCCTGTAAGTAGTGTT
TTGGTGAATAAATACGGCAGCCGGCCGGTGGTGATAGCAGGAGGCTTATTATGCTGTCTTGGAATGGTGTTGGCCTCCTTTAGTAGCAGC
GTGGTACAGCTGTACCTCACTATGGGATTCATTACAGGTTTAGGTTTAGCCTTCAACCTGCAACCCGCCTTAACCATAATTGGCAAATAC
TTCTATAGGAAGCGACCCATGGCAAATGGATTGGCCATGGCAGGAAGTCCTGTTTTCTTAAGTTCATTGGCTCCTTTCAATCAGTACCTT
TTTAATACTTTTGGCTGGAAAGGAAGCTTCCTGATTTTGGGAAGTCTACTTTTGAATGCCTGTGTGGCTGGTTCCCTCATGAGACCCCTT
GGACCCAATCAAACCACTTCTAAGTCTAAAAATAAGACTGGCAAAACAGAAGATGATTCAAGCCCAAAGAAAATCAAAACGAAGAAATCA
ACTTGGGAAAAAGTTAATAAGTATTTAGATTTCTCCCTTTTTAAGCATAGAGGATTTCTGATATATCTGTCTGGAAATGTCATTATGTTC
CTAGGTTTTTTTGCCCCCATTATATTCTTGGCTCCATATGCTAAAGACCAAGGAATTGATGAGTACTCGGCAGCTTTTCTGCTATCTGTT
ATGGCTTTCGTTGATATGTTTGCTAGGCCTTCTGTAGGATTAATTGCAAACTCCAAATATATTCGACCTCGAATTCAGTACTTCTTCAGT
TTTGCAATCATGTTCAATGGAGTGTGTCACCTCTTGTGCCCACTGGCACAGGACTACACAAGCCTGGTATTATATGCTGTATTTTTTGGC
CTTGGATTTGGGAGTGTTAGCAGTGTTCTCTTTGAAACTCTCATGGACCTCGTGGGTGCACCAAGATTTTCCAGTGCCGTCGGACTTGTC
ACAATTGTGGAGTGTGGCCCAGTTCTTCTTGGCCCTCCTCTTGCAGGTAAATTGGTGGATTTAACTGGAGAATATAAATACATGTACATG
TCCTGTGGGGCTATTGTGGTAGCAGCAAGCGTGTGGCTGCTCATTGGCAATGCTATCAACTATAGATTGCTTGCAAAGGAAAGGAAGGAG
GAAAATGCAAGGCAGAAGACCAGAGAATCTGAACCCTTGAGCAAATCTAAACATTCGGAAGATGTTAACGTCAAAGTTTCAAATGCACAG
AGTGTAACCTCAGAAAGAGAAACTAACATTTAACAAGAATCACATCTCTGATTTCAGTGTTTATGACTTTATCTAGGAGTTTGTTTTTCA
TTTTGTTTTTTTAAAGTATTAGAAAAGGTTTTAGCTGAAATGAGGAGTCACAATTAAGGATGGAGGTGATATTTTCCTCAATGGCAAATT
TTAAATTAGTTTTTAAAAACTTACTTATTTGGGTAGTTAAATTTTGAGATTATGCATAGAAAGAATCCATGCTATAGGTTTATTTCCATA

>81727_81727_5_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000414700_SLC16A7_chr12_60165000_ENST00000547379_length(amino acids)=876AA_BP=470
MLASGRGPGGSEGWKEVERPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSR
AALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHL
THGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAK
VIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSL
QVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFR
RVVDFIDEGVNIGLEVKSKTGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRK
RPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEK
VNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIM
FNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGA

--------------------------------------------------------------
>81727_81727_6_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000414700_SLC16A7_chr12_60165000_ENST00000552432_length(transcript)=3267nt_BP=1513nt
GCGGACCCGGTGCTGGCAAATGAGCGGAGTTTTCGGCCTGGTCTCACAAGCTGAGCCTTTCCGGCCAGCTCTGAGCCCTGCAGATGATGC
AACCGAGCTTCACTGCTTGCATCAGGCAGGGGTCCCGGCGGCAGTGAGGGCTGGAAGGAGGTGGAACGGCCTCTGCAGAGATGTGGGCAG
CTGGTCAGGATGGCCATTCGGGCTCAGCACAGCAACGCAGCCCAGACTCAGACTGGGGAAGCAAACAGGGGCTGGACAGGCCAGGAGAGC
CTGTCGGACAGTGATCCTGAGATGTGGGAGTTGCTGCAGAGGGAGAAGGACAGGCAGTGTCGTGGCCTGGAGCTCATTGCCTCAGAGAAC
TTCTGCAGCCGAGCTGCGCTGGAGGCCCTGGGGTCCTGTCTGAACAACAAGTACTCGGAGGGTTATCCTGGCAAGAGATACTATGGGGGA
GCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCCAGCGCCGGGCCTTGGAAGCCTTTGACCTGGATCCTGCACAGTGGGGAGTCAATGTC
CAGCCCTACTCCGGGTCCCCAGCCAACCTGGCCGTCTACACAGCCCTTCTGCAACCTCACGACCGGATCATGGGGCTGGACCTGCCCGAT
GGGGGCCATCTCACCCACGGCTACATGTCTGACGTCAAGCGGATATCAGCCACGTCCATCTTCTTCGAGTCTATGCCCTATAAGCTCAAC
CCCAAAACTGGCCTCATTGACTACAACCAGCTGGCACTGACTGCTCGACTTTTCCGGCCACGGCTCATCATAGCTGGCACCAGCGCCTAT
GCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTGTGATGAAGTCAAAGCACACCTGCTGGCAGACATGGCCCACATCAGTGGCCTG
GTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGCACGCGGACATCGTCACCACCACTACTCACAAGACTCTTCGAGGGGCCAGGTCAGGG
CTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCCCAAGACTGGCCGGGAGATCCCTTACACATTTGAGGACCGAATCAACTTTGCC
GTGTTCCCATCCCTGCAGGGGGGCCCCCACAATCATGCCATTGCTGCAGTAGCTGTGGCCCTAAAGCAGGCCTGCACCCCCATGTTCCGG
GAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCATGGCAGATGCCCTGCTAGAGCGAGGCTACTCACTGGTATCAGGTGGTACTGAC
AACCACCTGGTGCTGGTGGACCTGCGGCCCAAGGGCCTGGATGGAGCTCGGGCTGAGCGGGTGCTAGAGCTTGTATCCATCACTGCCAAC
AAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACCGGGCGGCCTGCGGCTTGGGGCCCCAGCCTTAACTTCTCGACAGTTCCGTGAG
GATGACTTCCGGAGAGTTGTGGACTTTATAGATGAAGGGGTCAACATTGGCTTAGAGGTGAAGAGCAAGACTGGTCCTGTAAGTAGTGTT
TTGGTGAATAAATACGGCAGCCGGCCGGTGGTGATAGCAGGAGGCTTATTATGCTGTCTTGGAATGGTGTTGGCCTCCTTTAGTAGCAGC
GTGGTACAGCTGTACCTCACTATGGGATTCATTACAGGTTTAGGTTTAGCCTTCAACCTGCAACCCGCCTTAACCATAATTGGCAAATAC
TTCTATAGGAAGCGACCCATGGCAAATGGATTGGCCATGGCAGGAAGTCCTGTTTTCTTAAGTTCATTGGCTCCTTTCAATCAGTACCTT
TTTAATACTTTTGGCTGGAAAGGAAGCTTCCTGATTTTGGGAAGTCTACTTTTGAATGCCTGTGTGGCTGGTTCCCTCATGAGACCCCTT
GGACCCAATCAAACCACTTCTAAGTCTAAAAATAAGACTGGCAAAACAGAAGATGATTCAAGCCCAAAGAAAATCAAAACGAAGAAATCA
ACTTGGGAAAAAGTTAATAAGTATTTAGATTTCTCCCTTTTTAAGCATAGAGGATTTCTGATATATCTGTCTGGAAATGTCATTATGTTC
CTAGGTTTTTTTGCCCCCATTATATTCTTGGCTCCATATGCTAAAGACCAAGGAATTGATGAGTACTCGGCAGCTTTTCTGCTATCTGTT
ATGGCTTTCGTTGATATGTTTGCTAGGCCTTCTGTAGGATTAATTGCAAACTCCAAATATATTCGACCTCGAATTCAGTACTTCTTCAGT
TTTGCAATCATGTTCAATGGAGTGTGTCACCTCTTGTGCCCACTGGCACAGGACTACACAAGCCTGGTATTATATGCTGTATTTTTTGGC
CTTGGATTTGGGAGTGTTAGCAGTGTTCTCTTTGAAACTCTCATGGACCTCGTGGGTGCACCAAGATTTTCCAGTGCCGTCGGACTTGTC
ACAATTGTGGAGTGTGGCCCAGTTCTTCTTGGCCCTCCTCTTGCAGGTAAATTGGTGGATTTAACTGGAGAATATAAATACATGTACATG
TCCTGTGGGGCTATTGTGGTAGCAGCAAGCGTGTGGCTGCTCATTGGCAATGCTATCAACTATAGATTGCTTGCAAAGGAAAGGAAGGAG
GAAAATGCAAGGCAGAAGACCAGAGAATCTGAACCCTTGAGCAAATCTAAACATTCGGAAGATGTTAACGTCAAAGTTTCAAATGCACAG
AGTGTAACCTCAGAAAGAGAAACTAACATTTAACAAGAATCACATCTCTGATTTCAGTGTTTATGACTTTATCTAGGAGTTTGTTTTTCA
TTTTGTTTTTTTAAAGTATTAGAAAAGGTTTTAGCTGAAATGAGGAGTCACAATTAAGGATGGAGGTGATATTTTCCTCAATGGCAAATT
TTAAATTAGTTTTTAAAAACTTACTTATTTGGGTAGTTAAATTTTGAGATTATGCATAGAAAGAATCCATGCTATAGGTTTATTTCCATA
CCTGACTCTGGGTGTGGTGGTTAAAATACTAATTTTAAAGTCTTCCAGTGACTTTCGGTCTTGGTTATATGGAGAATTCTGAATCCCAAA
CCCCTGGTTTAAGTAGGTAGAAGGAGGATGCCTAATCCTACAAAGTGACCCTTTATACATTTCATTTTTTATTTGATATTAAAGTATGAG
ATAGAGTTGAGAGACAATTAATTATCCCCTCTTACACACAAACACACATACTCCCACATACTTACCCACATGTACACAGAGTATCTGGAG

>81727_81727_6_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000414700_SLC16A7_chr12_60165000_ENST00000552432_length(amino acids)=876AA_BP=470
MLASGRGPGGSEGWKEVERPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSR
AALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHL
THGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAK
VIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSL
QVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFR
RVVDFIDEGVNIGLEVKSKTGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRK
RPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEK
VNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIM
FNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGA

--------------------------------------------------------------
>81727_81727_7_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000449049_SLC16A7_chr12_60165000_ENST00000547379_length(transcript)=3185nt_BP=1655nt
ATTGCTCTACAATCTGTGGCCTCAGCCCTTGCCAACTCTGCCTCTTCCCCCGCTGACTGGGGTATCAGTTTATGGTGCCCTGCAGGAAGA
CCCTCTTGTTCCTGTGGGTGGGAAGGTTCTGGAATCTCAGTTGCCCTCTCTGGAGTTGGGGAGACATAGGCTTTTGGAGGACAAGCTTTG
CAGAGTGGTTCATGGAGTGAGGTGGTGGGAGATTTCTGAGGTGCGGTGCGGTGAATGGAGCAAATCAGAACCACCCCTTGGACGTTGATC
TCAAGCTTGGCTCCAGAACTGGCTTTTGAAGCCTCTGCAGAGATGTGGGCAGCTGGTCAGGATGGCCATTCGGGCTCAGCACAGCAACGC
AGCCCAGACTCAGACTGGGGAAGCAAACAGGGGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATCCTGAGATGTGGGAGTTGCTGCA
GAGGGAGAAGGACAGGCAGTGTCGTGGCCTGGAGCTCATTGCCTCAGAGAACTTCTGCAGCCGAGCTGCGCTGGAGGCCCTGGGGTCCTG
TCTGAACAACAAGTACTCGGAGGGTTATCCTGGCAAGAGATACTATGGGGGAGCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCCAGCG
CCGGGCCTTGGAAGCCTTTGACCTGGATCCTGCACAGTGGGGAGTCAATGTCCAGCCCTACTCCGGGTCCCCAGCCAACCTGGCCGTCTA
CACAGCCCTTCTGCAACCTCACGACCGGATCATGGGGCTGGACCTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGACGTCAA
GCGGATATCAGCCACGTCCATCTTCTTCGAGTCTATGCCCTATAAGCTCAACCCCAAAACTGGCCTCATTGACTACAACCAGCTGGCACT
GACTGCTCGACTTTTCCGGCCACGGCTCATCATAGCTGGCACCAGCGCCTATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTG
TGATGAAGTCAAAGCACACCTGCTGGCAGACATGGCCCACATCAGTGGCCTGGTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGCACGC
GGACATCGTCACCACCACTACTCACAAGACTCTTCGAGGGGCCAGGTCAGGGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCC
CAAGACTGGCCGGGAGATCCCTTACACATTTGAGGACCGAATCAACTTTGCCGTGTTCCCATCCCTGCAGGGGGGCCCCCACAATCATGC
CATTGCTGCAGTAGCTGTGGCCCTAAAGCAGGCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCAT
GGCAGATGCCCTGCTAGAGCGAGGCTACTCACTGGTATCAGGTGGTACTGACAACCACCTGGTGCTGGTGGACCTGCGGCCCAAGGGCCT
GGATGGAGCTCGGGCTGAGCGGGTGCTAGAGCTTGTATCCATCACTGCCAACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACC
GGGCGGCCTGCGGCTTGGGGCCCCAGCCTTAACTTCTCGACAGTTCCGTGAGGATGACTTCCGGAGAGTTGTGGACTTTATAGATGAAGG
GGTCAACATTGGCTTAGAGGTGAAGAGCAAGACTGGTCCTGTAAGTAGTGTTTTGGTGAATAAATACGGCAGCCGGCCGGTGGTGATAGC
AGGAGGCTTATTATGCTGTCTTGGAATGGTGTTGGCCTCCTTTAGTAGCAGCGTGGTACAGCTGTACCTCACTATGGGATTCATTACAGG
TTTAGGTTTAGCCTTCAACCTGCAACCCGCCTTAACCATAATTGGCAAATACTTCTATAGGAAGCGACCCATGGCAAATGGATTGGCCAT
GGCAGGAAGTCCTGTTTTCTTAAGTTCATTGGCTCCTTTCAATCAGTACCTTTTTAATACTTTTGGCTGGAAAGGAAGCTTCCTGATTTT
GGGAAGTCTACTTTTGAATGCCTGTGTGGCTGGTTCCCTCATGAGACCCCTTGGACCCAATCAAACCACTTCTAAGTCTAAAAATAAGAC
TGGCAAAACAGAAGATGATTCAAGCCCAAAGAAAATCAAAACGAAGAAATCAACTTGGGAAAAAGTTAATAAGTATTTAGATTTCTCCCT
TTTTAAGCATAGAGGATTTCTGATATATCTGTCTGGAAATGTCATTATGTTCCTAGGTTTTTTTGCCCCCATTATATTCTTGGCTCCATA
TGCTAAAGACCAAGGAATTGATGAGTACTCGGCAGCTTTTCTGCTATCTGTTATGGCTTTCGTTGATATGTTTGCTAGGCCTTCTGTAGG
ATTAATTGCAAACTCCAAATATATTCGACCTCGAATTCAGTACTTCTTCAGTTTTGCAATCATGTTCAATGGAGTGTGTCACCTCTTGTG
CCCACTGGCACAGGACTACACAAGCCTGGTATTATATGCTGTATTTTTTGGCCTTGGATTTGGGAGTGTTAGCAGTGTTCTCTTTGAAAC
TCTCATGGACCTCGTGGGTGCACCAAGATTTTCCAGTGCCGTCGGACTTGTCACAATTGTGGAGTGTGGCCCAGTTCTTCTTGGCCCTCC
TCTTGCAGGTAAATTGGTGGATTTAACTGGAGAATATAAATACATGTACATGTCCTGTGGGGCTATTGTGGTAGCAGCAAGCGTGTGGCT
GCTCATTGGCAATGCTATCAACTATAGATTGCTTGCAAAGGAAAGGAAGGAGGAAAATGCAAGGCAGAAGACCAGAGAATCTGAACCCTT
GAGCAAATCTAAACATTCGGAAGATGTTAACGTCAAAGTTTCAAATGCACAGAGTGTAACCTCAGAAAGAGAAACTAACATTTAACAAGA
ATCACATCTCTGATTTCAGTGTTTATGACTTTATCTAGGAGTTTGTTTTTCATTTTGTTTTTTTAAAGTATTAGAAAAGGTTTTAGCTGA
AATGAGGAGTCACAATTAAGGATGGAGGTGATATTTTCCTCAATGGCAAATTTTAAATTAGTTTTTAAAAACTTACTTATTTGGGTAGTT
AAATTTTGAGATTATGCATAGAAAGAATCCATGCTATAGGTTTATTTCCATACCTGACTCTGGGTGTGGTGGTTAAAATACTAATTTTAA

>81727_81727_7_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000449049_SLC16A7_chr12_60165000_ENST00000547379_length(amino acids)=859AA_BP=453
MKPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEG
YPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIF
FESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTH
KTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERG
YSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVK
SKTGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLS
SLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLI
YLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTS
LVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAINY

--------------------------------------------------------------
>81727_81727_8_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000449049_SLC16A7_chr12_60165000_ENST00000552432_length(transcript)=3409nt_BP=1655nt
ATTGCTCTACAATCTGTGGCCTCAGCCCTTGCCAACTCTGCCTCTTCCCCCGCTGACTGGGGTATCAGTTTATGGTGCCCTGCAGGAAGA
CCCTCTTGTTCCTGTGGGTGGGAAGGTTCTGGAATCTCAGTTGCCCTCTCTGGAGTTGGGGAGACATAGGCTTTTGGAGGACAAGCTTTG
CAGAGTGGTTCATGGAGTGAGGTGGTGGGAGATTTCTGAGGTGCGGTGCGGTGAATGGAGCAAATCAGAACCACCCCTTGGACGTTGATC
TCAAGCTTGGCTCCAGAACTGGCTTTTGAAGCCTCTGCAGAGATGTGGGCAGCTGGTCAGGATGGCCATTCGGGCTCAGCACAGCAACGC
AGCCCAGACTCAGACTGGGGAAGCAAACAGGGGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATCCTGAGATGTGGGAGTTGCTGCA
GAGGGAGAAGGACAGGCAGTGTCGTGGCCTGGAGCTCATTGCCTCAGAGAACTTCTGCAGCCGAGCTGCGCTGGAGGCCCTGGGGTCCTG
TCTGAACAACAAGTACTCGGAGGGTTATCCTGGCAAGAGATACTATGGGGGAGCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCCAGCG
CCGGGCCTTGGAAGCCTTTGACCTGGATCCTGCACAGTGGGGAGTCAATGTCCAGCCCTACTCCGGGTCCCCAGCCAACCTGGCCGTCTA
CACAGCCCTTCTGCAACCTCACGACCGGATCATGGGGCTGGACCTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGACGTCAA
GCGGATATCAGCCACGTCCATCTTCTTCGAGTCTATGCCCTATAAGCTCAACCCCAAAACTGGCCTCATTGACTACAACCAGCTGGCACT
GACTGCTCGACTTTTCCGGCCACGGCTCATCATAGCTGGCACCAGCGCCTATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTG
TGATGAAGTCAAAGCACACCTGCTGGCAGACATGGCCCACATCAGTGGCCTGGTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGCACGC
GGACATCGTCACCACCACTACTCACAAGACTCTTCGAGGGGCCAGGTCAGGGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCC
CAAGACTGGCCGGGAGATCCCTTACACATTTGAGGACCGAATCAACTTTGCCGTGTTCCCATCCCTGCAGGGGGGCCCCCACAATCATGC
CATTGCTGCAGTAGCTGTGGCCCTAAAGCAGGCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCAT
GGCAGATGCCCTGCTAGAGCGAGGCTACTCACTGGTATCAGGTGGTACTGACAACCACCTGGTGCTGGTGGACCTGCGGCCCAAGGGCCT
GGATGGAGCTCGGGCTGAGCGGGTGCTAGAGCTTGTATCCATCACTGCCAACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACC
GGGCGGCCTGCGGCTTGGGGCCCCAGCCTTAACTTCTCGACAGTTCCGTGAGGATGACTTCCGGAGAGTTGTGGACTTTATAGATGAAGG
GGTCAACATTGGCTTAGAGGTGAAGAGCAAGACTGGTCCTGTAAGTAGTGTTTTGGTGAATAAATACGGCAGCCGGCCGGTGGTGATAGC
AGGAGGCTTATTATGCTGTCTTGGAATGGTGTTGGCCTCCTTTAGTAGCAGCGTGGTACAGCTGTACCTCACTATGGGATTCATTACAGG
TTTAGGTTTAGCCTTCAACCTGCAACCCGCCTTAACCATAATTGGCAAATACTTCTATAGGAAGCGACCCATGGCAAATGGATTGGCCAT
GGCAGGAAGTCCTGTTTTCTTAAGTTCATTGGCTCCTTTCAATCAGTACCTTTTTAATACTTTTGGCTGGAAAGGAAGCTTCCTGATTTT
GGGAAGTCTACTTTTGAATGCCTGTGTGGCTGGTTCCCTCATGAGACCCCTTGGACCCAATCAAACCACTTCTAAGTCTAAAAATAAGAC
TGGCAAAACAGAAGATGATTCAAGCCCAAAGAAAATCAAAACGAAGAAATCAACTTGGGAAAAAGTTAATAAGTATTTAGATTTCTCCCT
TTTTAAGCATAGAGGATTTCTGATATATCTGTCTGGAAATGTCATTATGTTCCTAGGTTTTTTTGCCCCCATTATATTCTTGGCTCCATA
TGCTAAAGACCAAGGAATTGATGAGTACTCGGCAGCTTTTCTGCTATCTGTTATGGCTTTCGTTGATATGTTTGCTAGGCCTTCTGTAGG
ATTAATTGCAAACTCCAAATATATTCGACCTCGAATTCAGTACTTCTTCAGTTTTGCAATCATGTTCAATGGAGTGTGTCACCTCTTGTG
CCCACTGGCACAGGACTACACAAGCCTGGTATTATATGCTGTATTTTTTGGCCTTGGATTTGGGAGTGTTAGCAGTGTTCTCTTTGAAAC
TCTCATGGACCTCGTGGGTGCACCAAGATTTTCCAGTGCCGTCGGACTTGTCACAATTGTGGAGTGTGGCCCAGTTCTTCTTGGCCCTCC
TCTTGCAGGTAAATTGGTGGATTTAACTGGAGAATATAAATACATGTACATGTCCTGTGGGGCTATTGTGGTAGCAGCAAGCGTGTGGCT
GCTCATTGGCAATGCTATCAACTATAGATTGCTTGCAAAGGAAAGGAAGGAGGAAAATGCAAGGCAGAAGACCAGAGAATCTGAACCCTT
GAGCAAATCTAAACATTCGGAAGATGTTAACGTCAAAGTTTCAAATGCACAGAGTGTAACCTCAGAAAGAGAAACTAACATTTAACAAGA
ATCACATCTCTGATTTCAGTGTTTATGACTTTATCTAGGAGTTTGTTTTTCATTTTGTTTTTTTAAAGTATTAGAAAAGGTTTTAGCTGA
AATGAGGAGTCACAATTAAGGATGGAGGTGATATTTTCCTCAATGGCAAATTTTAAATTAGTTTTTAAAAACTTACTTATTTGGGTAGTT
AAATTTTGAGATTATGCATAGAAAGAATCCATGCTATAGGTTTATTTCCATACCTGACTCTGGGTGTGGTGGTTAAAATACTAATTTTAA
AGTCTTCCAGTGACTTTCGGTCTTGGTTATATGGAGAATTCTGAATCCCAAACCCCTGGTTTAAGTAGGTAGAAGGAGGATGCCTAATCC
TACAAAGTGACCCTTTATACATTTCATTTTTTATTTGATATTAAAGTATGAGATAGAGTTGAGAGACAATTAATTATCCCCTCTTACACA

>81727_81727_8_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000449049_SLC16A7_chr12_60165000_ENST00000552432_length(amino acids)=859AA_BP=453
MKPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEG
YPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIF
FESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTH
KTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERG
YSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVK
SKTGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLS
SLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLI
YLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTS
LVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAINY

--------------------------------------------------------------
>81727_81727_9_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000553474_SLC16A7_chr12_60165000_ENST00000547379_length(transcript)=2977nt_BP=1447nt
ACGGACTGCTAAAGGTCTCCCCTCCCACCTGCATTGCTCTACAATCTGTGGCCTCAGCCCTTGCCAACTCTGCCTCTTCCCCCGCTGACT
GGGCCTCTGCAGAGATGTGGGCAGCTGGTCAGGATGGCCATTCGGGCTCAGCACAGCAACGCAGCCCAGACTCAGACTGGGGAAGCAAAC
AGGGGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATCCTGAGATGTGGGAGTTGCTGCAGAGGGAGAAGGACAGGCAGTGTCGTGGC
CTGGAGCTCATTGCCTCAGAGAACTTCTGCAGCCGAGCTGCGCTGGAGGCCCTGGGGTCCTGTCTGAACAACAAGTACTCGGAGGGTTAT
CCTGGCAAGAGATACTATGGGGGAGCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCCAGCGCCGGGCCTTGGAAGCCTTTGACCTGGAT
CCTGCACAGTGGGGAGTCAATGTCCAGCCCTACTCCGGGTCCCCAGCCAACCTGGCCGTCTACACAGCCCTTCTGCAACCTCACGACCGG
ATCATGGGGCTGGACCTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGACGTCAAGCGGATATCAGCCACGTCCATCTTCTTC
GAGTCTATGCCCTATAAGCTCAACCCCAAAACTGGCCTCATTGACTACAACCAGCTGGCACTGACTGCTCGACTTTTCCGGCCACGGCTC
ATCATAGCTGGCACCAGCGCCTATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTGTGATGAAGTCAAAGCACACCTGCTGGCA
GACATGGCCCACATCAGTGGCCTGGTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGCACGCGGACATCGTCACCACCACTACTCACAAG
ACTCTTCGAGGGGCCAGGTCAGGGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCCCAAGACTGGCCGGGAGATCCCTTACACA
TTTGAGGACCGAATCAACTTTGCCGTGTTCCCATCCCTGCAGGGGGGCCCCCACAATCATGCCATTGCTGCAGTAGCTGTGGCCCTAAAG
CAGGCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCATGGCAGATGCCCTGCTAGAGCGAGGCTAC
TCACTGGTATCAGGTGGTACTGACAACCACCTGGTGCTGGTGGACCTGCGGCCCAAGGGCCTGGATGGAGCTCGGGCTGAGCGGGTGCTA
GAGCTTGTATCCATCACTGCCAACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACCGGGCGGCCTGCGGCTTGGGGCCCCAGCC
TTAACTTCTCGACAGTTCCGTGAGGATGACTTCCGGAGAGTTGTGGACTTTATAGATGAAGGGGTCAACATTGGCTTAGAGGTGAAGAGC
AAGACTGGTCCTGTAAGTAGTGTTTTGGTGAATAAATACGGCAGCCGGCCGGTGGTGATAGCAGGAGGCTTATTATGCTGTCTTGGAATG
GTGTTGGCCTCCTTTAGTAGCAGCGTGGTACAGCTGTACCTCACTATGGGATTCATTACAGGTTTAGGTTTAGCCTTCAACCTGCAACCC
GCCTTAACCATAATTGGCAAATACTTCTATAGGAAGCGACCCATGGCAAATGGATTGGCCATGGCAGGAAGTCCTGTTTTCTTAAGTTCA
TTGGCTCCTTTCAATCAGTACCTTTTTAATACTTTTGGCTGGAAAGGAAGCTTCCTGATTTTGGGAAGTCTACTTTTGAATGCCTGTGTG
GCTGGTTCCCTCATGAGACCCCTTGGACCCAATCAAACCACTTCTAAGTCTAAAAATAAGACTGGCAAAACAGAAGATGATTCAAGCCCA
AAGAAAATCAAAACGAAGAAATCAACTTGGGAAAAAGTTAATAAGTATTTAGATTTCTCCCTTTTTAAGCATAGAGGATTTCTGATATAT
CTGTCTGGAAATGTCATTATGTTCCTAGGTTTTTTTGCCCCCATTATATTCTTGGCTCCATATGCTAAAGACCAAGGAATTGATGAGTAC
TCGGCAGCTTTTCTGCTATCTGTTATGGCTTTCGTTGATATGTTTGCTAGGCCTTCTGTAGGATTAATTGCAAACTCCAAATATATTCGA
CCTCGAATTCAGTACTTCTTCAGTTTTGCAATCATGTTCAATGGAGTGTGTCACCTCTTGTGCCCACTGGCACAGGACTACACAAGCCTG
GTATTATATGCTGTATTTTTTGGCCTTGGATTTGGGAGTGTTAGCAGTGTTCTCTTTGAAACTCTCATGGACCTCGTGGGTGCACCAAGA
TTTTCCAGTGCCGTCGGACTTGTCACAATTGTGGAGTGTGGCCCAGTTCTTCTTGGCCCTCCTCTTGCAGGTAAATTGGTGGATTTAACT
GGAGAATATAAATACATGTACATGTCCTGTGGGGCTATTGTGGTAGCAGCAAGCGTGTGGCTGCTCATTGGCAATGCTATCAACTATAGA
TTGCTTGCAAAGGAAAGGAAGGAGGAAAATGCAAGGCAGAAGACCAGAGAATCTGAACCCTTGAGCAAATCTAAACATTCGGAAGATGTT
AACGTCAAAGTTTCAAATGCACAGAGTGTAACCTCAGAAAGAGAAACTAACATTTAACAAGAATCACATCTCTGATTTCAGTGTTTATGA
CTTTATCTAGGAGTTTGTTTTTCATTTTGTTTTTTTAAAGTATTAGAAAAGGTTTTAGCTGAAATGAGGAGTCACAATTAAGGATGGAGG
TGATATTTTCCTCAATGGCAAATTTTAAATTAGTTTTTAAAAACTTACTTATTTGGGTAGTTAAATTTTGAGATTATGCATAGAAAGAAT
CCATGCTATAGGTTTATTTCCATACCTGACTCTGGGTGTGGTGGTTAAAATACTAATTTTAAAGTCTTCCAGTGACTTTCGGTCTTGGTT

>81727_81727_9_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000553474_SLC16A7_chr12_60165000_ENST00000547379_length(amino acids)=877AA_BP=471
MLYNLWPQPLPTLPLPPLTGPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCS
RAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGH
LTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAA
KVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYS
LQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDF
RRVVDFIDEGVNIGLEVKSKTGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYR
KRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWE
KVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAI
MFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCG

--------------------------------------------------------------
>81727_81727_10_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000553474_SLC16A7_chr12_60165000_ENST00000552432_length(transcript)=3201nt_BP=1447nt
ACGGACTGCTAAAGGTCTCCCCTCCCACCTGCATTGCTCTACAATCTGTGGCCTCAGCCCTTGCCAACTCTGCCTCTTCCCCCGCTGACT
GGGCCTCTGCAGAGATGTGGGCAGCTGGTCAGGATGGCCATTCGGGCTCAGCACAGCAACGCAGCCCAGACTCAGACTGGGGAAGCAAAC
AGGGGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATCCTGAGATGTGGGAGTTGCTGCAGAGGGAGAAGGACAGGCAGTGTCGTGGC
CTGGAGCTCATTGCCTCAGAGAACTTCTGCAGCCGAGCTGCGCTGGAGGCCCTGGGGTCCTGTCTGAACAACAAGTACTCGGAGGGTTAT
CCTGGCAAGAGATACTATGGGGGAGCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCCAGCGCCGGGCCTTGGAAGCCTTTGACCTGGAT
CCTGCACAGTGGGGAGTCAATGTCCAGCCCTACTCCGGGTCCCCAGCCAACCTGGCCGTCTACACAGCCCTTCTGCAACCTCACGACCGG
ATCATGGGGCTGGACCTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGACGTCAAGCGGATATCAGCCACGTCCATCTTCTTC
GAGTCTATGCCCTATAAGCTCAACCCCAAAACTGGCCTCATTGACTACAACCAGCTGGCACTGACTGCTCGACTTTTCCGGCCACGGCTC
ATCATAGCTGGCACCAGCGCCTATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTGTGATGAAGTCAAAGCACACCTGCTGGCA
GACATGGCCCACATCAGTGGCCTGGTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGCACGCGGACATCGTCACCACCACTACTCACAAG
ACTCTTCGAGGGGCCAGGTCAGGGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCCCAAGACTGGCCGGGAGATCCCTTACACA
TTTGAGGACCGAATCAACTTTGCCGTGTTCCCATCCCTGCAGGGGGGCCCCCACAATCATGCCATTGCTGCAGTAGCTGTGGCCCTAAAG
CAGGCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCATGGCAGATGCCCTGCTAGAGCGAGGCTAC
TCACTGGTATCAGGTGGTACTGACAACCACCTGGTGCTGGTGGACCTGCGGCCCAAGGGCCTGGATGGAGCTCGGGCTGAGCGGGTGCTA
GAGCTTGTATCCATCACTGCCAACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACCGGGCGGCCTGCGGCTTGGGGCCCCAGCC
TTAACTTCTCGACAGTTCCGTGAGGATGACTTCCGGAGAGTTGTGGACTTTATAGATGAAGGGGTCAACATTGGCTTAGAGGTGAAGAGC
AAGACTGGTCCTGTAAGTAGTGTTTTGGTGAATAAATACGGCAGCCGGCCGGTGGTGATAGCAGGAGGCTTATTATGCTGTCTTGGAATG
GTGTTGGCCTCCTTTAGTAGCAGCGTGGTACAGCTGTACCTCACTATGGGATTCATTACAGGTTTAGGTTTAGCCTTCAACCTGCAACCC
GCCTTAACCATAATTGGCAAATACTTCTATAGGAAGCGACCCATGGCAAATGGATTGGCCATGGCAGGAAGTCCTGTTTTCTTAAGTTCA
TTGGCTCCTTTCAATCAGTACCTTTTTAATACTTTTGGCTGGAAAGGAAGCTTCCTGATTTTGGGAAGTCTACTTTTGAATGCCTGTGTG
GCTGGTTCCCTCATGAGACCCCTTGGACCCAATCAAACCACTTCTAAGTCTAAAAATAAGACTGGCAAAACAGAAGATGATTCAAGCCCA
AAGAAAATCAAAACGAAGAAATCAACTTGGGAAAAAGTTAATAAGTATTTAGATTTCTCCCTTTTTAAGCATAGAGGATTTCTGATATAT
CTGTCTGGAAATGTCATTATGTTCCTAGGTTTTTTTGCCCCCATTATATTCTTGGCTCCATATGCTAAAGACCAAGGAATTGATGAGTAC
TCGGCAGCTTTTCTGCTATCTGTTATGGCTTTCGTTGATATGTTTGCTAGGCCTTCTGTAGGATTAATTGCAAACTCCAAATATATTCGA
CCTCGAATTCAGTACTTCTTCAGTTTTGCAATCATGTTCAATGGAGTGTGTCACCTCTTGTGCCCACTGGCACAGGACTACACAAGCCTG
GTATTATATGCTGTATTTTTTGGCCTTGGATTTGGGAGTGTTAGCAGTGTTCTCTTTGAAACTCTCATGGACCTCGTGGGTGCACCAAGA
TTTTCCAGTGCCGTCGGACTTGTCACAATTGTGGAGTGTGGCCCAGTTCTTCTTGGCCCTCCTCTTGCAGGTAAATTGGTGGATTTAACT
GGAGAATATAAATACATGTACATGTCCTGTGGGGCTATTGTGGTAGCAGCAAGCGTGTGGCTGCTCATTGGCAATGCTATCAACTATAGA
TTGCTTGCAAAGGAAAGGAAGGAGGAAAATGCAAGGCAGAAGACCAGAGAATCTGAACCCTTGAGCAAATCTAAACATTCGGAAGATGTT
AACGTCAAAGTTTCAAATGCACAGAGTGTAACCTCAGAAAGAGAAACTAACATTTAACAAGAATCACATCTCTGATTTCAGTGTTTATGA
CTTTATCTAGGAGTTTGTTTTTCATTTTGTTTTTTTAAAGTATTAGAAAAGGTTTTAGCTGAAATGAGGAGTCACAATTAAGGATGGAGG
TGATATTTTCCTCAATGGCAAATTTTAAATTAGTTTTTAAAAACTTACTTATTTGGGTAGTTAAATTTTGAGATTATGCATAGAAAGAAT
CCATGCTATAGGTTTATTTCCATACCTGACTCTGGGTGTGGTGGTTAAAATACTAATTTTAAAGTCTTCCAGTGACTTTCGGTCTTGGTT
ATATGGAGAATTCTGAATCCCAAACCCCTGGTTTAAGTAGGTAGAAGGAGGATGCCTAATCCTACAAAGTGACCCTTTATACATTTCATT
TTTTATTTGATATTAAAGTATGAGATAGAGTTGAGAGACAATTAATTATCCCCTCTTACACACAAACACACATACTCCCACATACTTACC

>81727_81727_10_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000553474_SLC16A7_chr12_60165000_ENST00000552432_length(amino acids)=877AA_BP=471
MLYNLWPQPLPTLPLPPLTGPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCS
RAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGH
LTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAA
KVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYS
LQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDF
RRVVDFIDEGVNIGLEVKSKTGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYR
KRPMANGLAMAGSPVFLSSLAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWE
KVNKYLDFSLFKHRGFLIYLSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAI
MFNGVCHLLCPLAQDYTSLVLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCG

--------------------------------------------------------------
>81727_81727_11_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000557487_SLC16A7_chr12_60165000_ENST00000547379_length(transcript)=2955nt_BP=1425nt
CTTCTTCCGACAGCTTGCTGCCCTAGACCAGAGTTGGTGGCTGGACCTCCTGCGACTTCCGAGTTGCGATGCTGTACTTCTCTTTGTTTT
GGGCGGCTCGGCCTCTGCAGAGATGTGGGCAGCTGGTCAGGATGGCCATTCGGGCTCAGCACAGCAACGCAGCCCAGACTCAGACTGGGG
AAGCAAACAGGGGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATCCTGAGATGTGGGAGTTGCTGCAGAGGGAGAAGGACAGGCAGT
GTCGTGGCCTGGAGCTCATTGCCTCAGAGAACTTCTGCAGCCGAGCTGCGCTGGAGGCCCTGGGGTCCTGTCTGAACAACAAGTACTCGG
AGGGTTATCCTGGCAAGAGATACTATGGGGGAGCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCCAGCGCCGGGCCTTGGAAGCCTTTG
ACCTGGATCCTGCACAGTGGGGAGTCAATGTCCAGCCCTACTCCGGGTCCCCAGCCAACCTGGCCGTCTACACAGCCCTTCTGCAACCTC
ACGACCGGATCATGGGGCTGGACCTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGACGTCAAGCGGATATCAGCCACGTCCA
TCTTCTTCGAGTCTATGCCCTATAAGCTCAACCTGGCACTGACTGCTCGACTTTTCCGGCCACGGCTCATCATAGCTGGCACCAGCGCCT
ATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTGTGATGAAGTCAAAGCACACCTGCTGGCAGACATGGCCCACATCAGTGGCC
TGGTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGCACGCGGACATCGTCACCACCACTACTCACAAGACTCTTCGAGGGGCCAGGTCAG
GGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCCCAAGACTGGCCGGGAGATCCCTTACACATTTGAGGACCGAATCAACTTTG
CCGTGTTCCCATCCCTGCAGGGGGGCCCCCACAATCATGCCATTGCTGCAGTAGCTGTGGCCCTAAAGCAGGCCTGCACCCCCATGTTCC
GGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCATGGCAGATGCCCTGCTAGAGCGAGGCTACTCACTGGTATCAGGTGGTACTG
ACAACCACCTGGTGCTGGTGGACCTGCGGCCCAAGGGCCTGGATGGAGCTCGGGCTGAGCGGGTGCTAGAGCTTGTATCCATCACTGCCA
ACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACCGGGCGGCCTGCGGCTTGGGGCCCCAGCCTTAACTTCTCGACAGTTCCGTG
AGGATGACTTCCGGAGAGTTGTGGACTTTATAGATGAAGGGGTCAACATTGGCTTAGAGGTGAAGAGCAAGACTGGTCCTGTAAGTAGTG
TTTTGGTGAATAAATACGGCAGCCGGCCGGTGGTGATAGCAGGAGGCTTATTATGCTGTCTTGGAATGGTGTTGGCCTCCTTTAGTAGCA
GCGTGGTACAGCTGTACCTCACTATGGGATTCATTACAGGTTTAGGTTTAGCCTTCAACCTGCAACCCGCCTTAACCATAATTGGCAAAT
ACTTCTATAGGAAGCGACCCATGGCAAATGGATTGGCCATGGCAGGAAGTCCTGTTTTCTTAAGTTCATTGGCTCCTTTCAATCAGTACC
TTTTTAATACTTTTGGCTGGAAAGGAAGCTTCCTGATTTTGGGAAGTCTACTTTTGAATGCCTGTGTGGCTGGTTCCCTCATGAGACCCC
TTGGACCCAATCAAACCACTTCTAAGTCTAAAAATAAGACTGGCAAAACAGAAGATGATTCAAGCCCAAAGAAAATCAAAACGAAGAAAT
CAACTTGGGAAAAAGTTAATAAGTATTTAGATTTCTCCCTTTTTAAGCATAGAGGATTTCTGATATATCTGTCTGGAAATGTCATTATGT
TCCTAGGTTTTTTTGCCCCCATTATATTCTTGGCTCCATATGCTAAAGACCAAGGAATTGATGAGTACTCGGCAGCTTTTCTGCTATCTG
TTATGGCTTTCGTTGATATGTTTGCTAGGCCTTCTGTAGGATTAATTGCAAACTCCAAATATATTCGACCTCGAATTCAGTACTTCTTCA
GTTTTGCAATCATGTTCAATGGAGTGTGTCACCTCTTGTGCCCACTGGCACAGGACTACACAAGCCTGGTATTATATGCTGTATTTTTTG
GCCTTGGATTTGGGAGTGTTAGCAGTGTTCTCTTTGAAACTCTCATGGACCTCGTGGGTGCACCAAGATTTTCCAGTGCCGTCGGACTTG
TCACAATTGTGGAGTGTGGCCCAGTTCTTCTTGGCCCTCCTCTTGCAGGTAAATTGGTGGATTTAACTGGAGAATATAAATACATGTACA
TGTCCTGTGGGGCTATTGTGGTAGCAGCAAGCGTGTGGCTGCTCATTGGCAATGCTATCAACTATAGATTGCTTGCAAAGGAAAGGAAGG
AGGAAAATGCAAGGCAGAAGACCAGAGAATCTGAACCCTTGAGCAAATCTAAACATTCGGAAGATGTTAACGTCAAAGTTTCAAATGCAC
AGAGTGTAACCTCAGAAAGAGAAACTAACATTTAACAAGAATCACATCTCTGATTTCAGTGTTTATGACTTTATCTAGGAGTTTGTTTTT
CATTTTGTTTTTTTAAAGTATTAGAAAAGGTTTTAGCTGAAATGAGGAGTCACAATTAAGGATGGAGGTGATATTTTCCTCAATGGCAAA
TTTTAAATTAGTTTTTAAAAACTTACTTATTTGGGTAGTTAAATTTTGAGATTATGCATAGAAAGAATCCATGCTATAGGTTTATTTCCA

>81727_81727_11_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000557487_SLC16A7_chr12_60165000_ENST00000547379_length(amino acids)=858AA_BP=452
MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGS
CLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV
KRISATSIFFESMPYKLNLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHK
TLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGY
SLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKS
KTGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSS
LAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIY
LSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSL
VLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAINYR

--------------------------------------------------------------
>81727_81727_12_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000557487_SLC16A7_chr12_60165000_ENST00000552432_length(transcript)=3179nt_BP=1425nt
CTTCTTCCGACAGCTTGCTGCCCTAGACCAGAGTTGGTGGCTGGACCTCCTGCGACTTCCGAGTTGCGATGCTGTACTTCTCTTTGTTTT
GGGCGGCTCGGCCTCTGCAGAGATGTGGGCAGCTGGTCAGGATGGCCATTCGGGCTCAGCACAGCAACGCAGCCCAGACTCAGACTGGGG
AAGCAAACAGGGGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATCCTGAGATGTGGGAGTTGCTGCAGAGGGAGAAGGACAGGCAGT
GTCGTGGCCTGGAGCTCATTGCCTCAGAGAACTTCTGCAGCCGAGCTGCGCTGGAGGCCCTGGGGTCCTGTCTGAACAACAAGTACTCGG
AGGGTTATCCTGGCAAGAGATACTATGGGGGAGCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCCAGCGCCGGGCCTTGGAAGCCTTTG
ACCTGGATCCTGCACAGTGGGGAGTCAATGTCCAGCCCTACTCCGGGTCCCCAGCCAACCTGGCCGTCTACACAGCCCTTCTGCAACCTC
ACGACCGGATCATGGGGCTGGACCTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGACGTCAAGCGGATATCAGCCACGTCCA
TCTTCTTCGAGTCTATGCCCTATAAGCTCAACCTGGCACTGACTGCTCGACTTTTCCGGCCACGGCTCATCATAGCTGGCACCAGCGCCT
ATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTGTGATGAAGTCAAAGCACACCTGCTGGCAGACATGGCCCACATCAGTGGCC
TGGTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGCACGCGGACATCGTCACCACCACTACTCACAAGACTCTTCGAGGGGCCAGGTCAG
GGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCCCAAGACTGGCCGGGAGATCCCTTACACATTTGAGGACCGAATCAACTTTG
CCGTGTTCCCATCCCTGCAGGGGGGCCCCCACAATCATGCCATTGCTGCAGTAGCTGTGGCCCTAAAGCAGGCCTGCACCCCCATGTTCC
GGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCATGGCAGATGCCCTGCTAGAGCGAGGCTACTCACTGGTATCAGGTGGTACTG
ACAACCACCTGGTGCTGGTGGACCTGCGGCCCAAGGGCCTGGATGGAGCTCGGGCTGAGCGGGTGCTAGAGCTTGTATCCATCACTGCCA
ACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACCGGGCGGCCTGCGGCTTGGGGCCCCAGCCTTAACTTCTCGACAGTTCCGTG
AGGATGACTTCCGGAGAGTTGTGGACTTTATAGATGAAGGGGTCAACATTGGCTTAGAGGTGAAGAGCAAGACTGGTCCTGTAAGTAGTG
TTTTGGTGAATAAATACGGCAGCCGGCCGGTGGTGATAGCAGGAGGCTTATTATGCTGTCTTGGAATGGTGTTGGCCTCCTTTAGTAGCA
GCGTGGTACAGCTGTACCTCACTATGGGATTCATTACAGGTTTAGGTTTAGCCTTCAACCTGCAACCCGCCTTAACCATAATTGGCAAAT
ACTTCTATAGGAAGCGACCCATGGCAAATGGATTGGCCATGGCAGGAAGTCCTGTTTTCTTAAGTTCATTGGCTCCTTTCAATCAGTACC
TTTTTAATACTTTTGGCTGGAAAGGAAGCTTCCTGATTTTGGGAAGTCTACTTTTGAATGCCTGTGTGGCTGGTTCCCTCATGAGACCCC
TTGGACCCAATCAAACCACTTCTAAGTCTAAAAATAAGACTGGCAAAACAGAAGATGATTCAAGCCCAAAGAAAATCAAAACGAAGAAAT
CAACTTGGGAAAAAGTTAATAAGTATTTAGATTTCTCCCTTTTTAAGCATAGAGGATTTCTGATATATCTGTCTGGAAATGTCATTATGT
TCCTAGGTTTTTTTGCCCCCATTATATTCTTGGCTCCATATGCTAAAGACCAAGGAATTGATGAGTACTCGGCAGCTTTTCTGCTATCTG
TTATGGCTTTCGTTGATATGTTTGCTAGGCCTTCTGTAGGATTAATTGCAAACTCCAAATATATTCGACCTCGAATTCAGTACTTCTTCA
GTTTTGCAATCATGTTCAATGGAGTGTGTCACCTCTTGTGCCCACTGGCACAGGACTACACAAGCCTGGTATTATATGCTGTATTTTTTG
GCCTTGGATTTGGGAGTGTTAGCAGTGTTCTCTTTGAAACTCTCATGGACCTCGTGGGTGCACCAAGATTTTCCAGTGCCGTCGGACTTG
TCACAATTGTGGAGTGTGGCCCAGTTCTTCTTGGCCCTCCTCTTGCAGGTAAATTGGTGGATTTAACTGGAGAATATAAATACATGTACA
TGTCCTGTGGGGCTATTGTGGTAGCAGCAAGCGTGTGGCTGCTCATTGGCAATGCTATCAACTATAGATTGCTTGCAAAGGAAAGGAAGG
AGGAAAATGCAAGGCAGAAGACCAGAGAATCTGAACCCTTGAGCAAATCTAAACATTCGGAAGATGTTAACGTCAAAGTTTCAAATGCAC
AGAGTGTAACCTCAGAAAGAGAAACTAACATTTAACAAGAATCACATCTCTGATTTCAGTGTTTATGACTTTATCTAGGAGTTTGTTTTT
CATTTTGTTTTTTTAAAGTATTAGAAAAGGTTTTAGCTGAAATGAGGAGTCACAATTAAGGATGGAGGTGATATTTTCCTCAATGGCAAA
TTTTAAATTAGTTTTTAAAAACTTACTTATTTGGGTAGTTAAATTTTGAGATTATGCATAGAAAGAATCCATGCTATAGGTTTATTTCCA
TACCTGACTCTGGGTGTGGTGGTTAAAATACTAATTTTAAAGTCTTCCAGTGACTTTCGGTCTTGGTTATATGGAGAATTCTGAATCCCA
AACCCCTGGTTTAAGTAGGTAGAAGGAGGATGCCTAATCCTACAAAGTGACCCTTTATACATTTCATTTTTTATTTGATATTAAAGTATG
AGATAGAGTTGAGAGACAATTAATTATCCCCTCTTACACACAAACACACATACTCCCACATACTTACCCACATGTACACAGAGTATCTGG

>81727_81727_12_SHMT2-SLC16A7_SHMT2_chr12_57627893_ENST00000557487_SLC16A7_chr12_60165000_ENST00000552432_length(amino acids)=858AA_BP=452
MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGS
CLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV
KRISATSIFFESMPYKLNLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHK
TLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGY
SLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKS
KTGPVSSVLVNKYGSRPVVIAGGLLCCLGMVLASFSSSVVQLYLTMGFITGLGLAFNLQPALTIIGKYFYRKRPMANGLAMAGSPVFLSS
LAPFNQYLFNTFGWKGSFLILGSLLLNACVAGSLMRPLGPNQTTSKSKNKTGKTEDDSSPKKIKTKKSTWEKVNKYLDFSLFKHRGFLIY
LSGNVIMFLGFFAPIIFLAPYAKDQGIDEYSAAFLLSVMAFVDMFARPSVGLIANSKYIRPRIQYFFSFAIMFNGVCHLLCPLAQDYTSL
VLYAVFFGLGFGSVSSVLFETLMDLVGAPRFSSAVGLVTIVECGPVLLGPPLAGKLVDLTGEYKYMYMSCGAIVVAASVWLLIGNAINYR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SHMT2-SLC16A7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SHMT2-SLC16A7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SHMT2-SLC16A7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource