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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SHMT2-SLC26A10 (FusionGDB2 ID:81728)

Fusion Gene Summary for SHMT2-SLC26A10

check button Fusion gene summary
Fusion gene informationFusion gene name: SHMT2-SLC26A10
Fusion gene ID: 81728
HgeneTgene
Gene symbol

SHMT2

SLC26A10

Gene ID

6472

65012

Gene nameserine hydroxymethyltransferase 2solute carrier family 26 member 10
SynonymsGLYA|HEL-S-51e|SHMT-
Cytomap

12q13.3

12q13.3

Type of geneprotein-codingprotein-coding
Descriptionserine hydroxymethyltransferase, mitochondrialGLY A+epididymis secretory sperm binding protein Li 51eglycine auxotroph A, human complement for hamsterglycine hydroxymethyltransferaseserine aldolaseserine hydroxymethylaseserine hydroxymethyltransfersolute carrier family 26 member 10
Modification date2020032720200329
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000328923, ENST00000393827, 
ENST00000414700, ENST00000449049, 
ENST00000553474, ENST00000557487, 
ENST00000554600, 		ENST00000490243, 
ENST00000320442, ENST00000379218, 
Fusion gene scores* DoF score7 X 6 X 4=1685 X 4 X 3=60
# samples 84
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/60*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SHMT2 [Title/Abstract] AND SLC26A10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSHMT2(57627893)-SLC26A10(58018649), # samples:1
Anticipated loss of major functional domain due to fusion event.SHMT2-SLC26A10 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SHMT2-SLC26A10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SHMT2-SLC26A10 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
SHMT2-SLC26A10 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSHMT2

GO:0006544

glycine metabolic process

25619277|29180469

HgeneSHMT2

GO:0006563

L-serine metabolic process

25619277|29180469

HgeneSHMT2

GO:0006730

one-carbon metabolic process

11516159|29180469|29364879|29452640

HgeneSHMT2

GO:0034340

response to type I interferon

24075985

HgeneSHMT2

GO:0046653

tetrahydrofolate metabolic process

24075985|25619277

HgeneSHMT2

GO:0051262

protein tetramerization

25619277

HgeneSHMT2

GO:0051289

protein homotetramerization

29180469


check buttonFusion gene breakpoints across SHMT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC26A10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-28-5207-01ASHMT2chr12

57627893

+SLC26A10chr12

58018649

+


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Fusion Gene ORF analysis for SHMT2-SLC26A10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000328923ENST00000490243SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
5CDS-3UTRENST00000393827ENST00000490243SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
5CDS-3UTRENST00000414700ENST00000490243SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
5CDS-3UTRENST00000449049ENST00000490243SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
5CDS-3UTRENST00000553474ENST00000490243SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
5CDS-3UTRENST00000557487ENST00000490243SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
Frame-shiftENST00000328923ENST00000320442SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
Frame-shiftENST00000393827ENST00000320442SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
Frame-shiftENST00000414700ENST00000320442SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
Frame-shiftENST00000449049ENST00000320442SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
Frame-shiftENST00000553474ENST00000320442SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
Frame-shiftENST00000557487ENST00000320442SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
In-frameENST00000328923ENST00000379218SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
In-frameENST00000393827ENST00000379218SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
In-frameENST00000414700ENST00000379218SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
In-frameENST00000449049ENST00000379218SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
In-frameENST00000553474ENST00000379218SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
In-frameENST00000557487ENST00000379218SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
intron-3CDSENST00000554600ENST00000320442SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
intron-3CDSENST00000554600ENST00000379218SHMT2chr12

57627893

+SLC26A10chr12

58018649

+
intron-3UTRENST00000554600ENST00000490243SHMT2chr12

57627893

+SLC26A10chr12

58018649

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000328923SHMT2chr1257627893+ENST00000379218SLC26A10chr1258018649+270918394521996514
ENST00000557487SHMT2chr1257627893+ENST00000379218SLC26A10chr1258018649+22951425681582504
ENST00000414700SHMT2chr1257627893+ENST00000379218SLC26A10chr1258018649+238315131021670522
ENST00000553474SHMT2chr1257627893+ENST00000379218SLC26A10chr1258018649+23171447331604523
ENST00000449049SHMT2chr1257627893+ENST00000379218SLC26A10chr1258018649+252516552951812505
ENST00000393827SHMT2chr1257627893+ENST00000379218SLC26A10chr1258018649+222513552561512418

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000328923ENST00000379218SHMT2chr1257627893+SLC26A10chr1258018649+0.0044792280.9955207
ENST00000557487ENST00000379218SHMT2chr1257627893+SLC26A10chr1258018649+0.0068637220.9931363
ENST00000414700ENST00000379218SHMT2chr1257627893+SLC26A10chr1258018649+0.0103566850.98964334
ENST00000553474ENST00000379218SHMT2chr1257627893+SLC26A10chr1258018649+0.0091817010.9908183
ENST00000449049ENST00000379218SHMT2chr1257627893+SLC26A10chr1258018649+0.0100520650.9899479
ENST00000393827ENST00000379218SHMT2chr1257627893+SLC26A10chr1258018649+0.083289580.91671044

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Fusion Genomic Features for SHMT2-SLC26A10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SHMT2chr1257627893+SLC26A10chr1258018648+0.0010369880.998963
SHMT2chr1257627893+SLC26A10chr1258018648+0.0010369880.998963

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SHMT2-SLC26A10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:57627893/chr12:58018649)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC26A10chr12:57627893chr12:58018649ENST00000320442814406_541409564.0DomainSTAS

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSLC26A10chr12:57627893chr12:58018649ENST00000379218915406_541444366.3333333333333DomainSTAS
TgeneSLC26A10chr12:57627893chr12:58018649ENST00000320442814116_136409564.0TransmembraneHelical
TgeneSLC26A10chr12:57627893chr12:58018649ENST00000320442814152_172409564.0TransmembraneHelical
TgeneSLC26A10chr12:57627893chr12:58018649ENST00000320442814352_372409564.0TransmembraneHelical
TgeneSLC26A10chr12:57627893chr12:58018649ENST0000032044281445_65409564.0TransmembraneHelical
TgeneSLC26A10chr12:57627893chr12:58018649ENST0000032044281475_91409564.0TransmembraneHelical
TgeneSLC26A10chr12:57627893chr12:58018649ENST00000379218915116_136444366.3333333333333TransmembraneHelical
TgeneSLC26A10chr12:57627893chr12:58018649ENST00000379218915152_172444366.3333333333333TransmembraneHelical
TgeneSLC26A10chr12:57627893chr12:58018649ENST00000379218915352_372444366.3333333333333TransmembraneHelical
TgeneSLC26A10chr12:57627893chr12:58018649ENST0000037921891545_65444366.3333333333333TransmembraneHelical
TgeneSLC26A10chr12:57627893chr12:58018649ENST0000037921891575_91444366.3333333333333TransmembraneHelical


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Fusion Gene Sequence for SHMT2-SLC26A10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81728_81728_1_SHMT2-SLC26A10_SHMT2_chr12_57627893_ENST00000328923_SLC26A10_chr12_58018649_ENST00000379218_length(transcript)=2709nt_BP=1839nt
ACGGTGCTTTCCAGTGTTCCATAGCTCTTTATCTTGTGTGGGGGTCTAGATCTCCTGGAGTCTAATAATGCTAGCTAGATATTCAGTAGG
CACCCTATAAACGTTTGTCTTGACAACAAGCAGAGAGAAAACCCTGAAAAGCTTCAAGATAGTAAGGAGAGGGGGCGGCACTGGACCTCT
GTTTTTGTTTTTTGTTTTTTTCCCCCCAGGCAAGGGCCTCTAACCCTGGGGCTACAGACGGGAATCATAAAGAAAAAAGCGGTGAGTGGG
CGAACTACAATTCCCAAAAGGCCACAAAGGGGCCACCACTACGCATGCGTAGATCCCTCCCGTTAGCTTTGGCGCCTCAGCGAGCTCTTC
TCGCGCATGCGTTCTCCGAACGGTCTTCTTCCGACAGCTTGCTGCCCTAGACCAGAGTTGGTGGCTGGACCTCCTGCGACTTCCGAGTTG
CGATGCTGTACTTCTCTTTGTTTTGGGCGGCTCGGCCTCTGCAGAGATGTGGGCAGCTGGTCAGGATGGCCATTCGGGCTCAGCACAGCA
ACGCAGCCCAGACTCAGACTGGGGAAGCAAACAGGGGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATCCTGAGATGTGGGAGTTGC
TGCAGAGGGAGAAGGACAGGCAGTGTCGTGGCCTGGAGCTCATTGCCTCAGAGAACTTCTGCAGCCGAGCTGCGCTGGAGGCCCTGGGGT
CCTGTCTGAACAACAAGTACTCGGAGGGTTATCCTGGCAAGAGATACTATGGGGGAGCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCC
AGCGCCGGGCCTTGGAAGCCTTTGACCTGGATCCTGCACAGTGGGGAGTCAATGTCCAGCCCTACTCCGGGTCCCCAGCCAACCTGGCCG
TCTACACAGCCCTTCTGCAACCTCACGACCGGATCATGGGGCTGGACCTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGACG
TCAAGCGGATATCAGCCACGTCCATCTTCTTCGAGTCTATGCCCTATAAGCTCAACCCCAAAACTGGCCTCATTGACTACAACCAGCTGG
CACTGACTGCTCGACTTTTCCGGCCACGGCTCATCATAGCTGGCACCAGCGCCTATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGG
TGTGTGATGAAGTCAAAGCACACCTGCTGGCAGACATGGCCCACATCAGTGGCCTGGTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGC
ACGCGGACATCGTCACCACCACTACTCACAAGACTCTTCGAGGGGCCAGGTCAGGGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGG
ACCCCAAGACTGGCCGGGAGATCCCTTACACATTTGAGGACCGAATCAACTTTGCCGTGTTCCCATCCCTGCAGGGGGGCCCCCACAATC
ATGCCATTGCTGCAGTAGCTGTGGCCCTAAAGCAGGCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGG
CCATGGCAGATGCCCTGCTAGAGCGAGGCTACTCACTGGTATCAGGTGGTACTGACAACCACCTGGTGCTGGTGGACCTGCGGCCCAAGG
GCCTGGATGGAGCTCGGGCTGAGCGGGTGCTAGAGCTTGTATCCATCACTGCCAACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCA
CACCGGGCGGCCTGCGGCTTGGGGCCCCAGCCTTAACTTCTCGACAGTTCCGTGAGGATGACTTCCGGAGAGTTGTGGACTTTATAGATG
AAGGGGTCAACATTGGCTTAGAGGTGAAGAGCAAGACTGCTCCTCCAGGTCCCGGGGCTCTGCATCCTGAGCTATCCAACACCACTGTAC
TTTGGGACCCGTGGGCAGTTTCGCTGCAACCTGGAGTGGCACCTGGGGCTCGGAGAAGGAGAAAAGGAGACTTCAAAGCCAGATGGCCCA
ATGGTTGCAGTTGCTGAGCCTGTCAGGGTGGTGGTCCTAGACTTCAGTGGTGTCACCTTTGCAGATGCTGCTGGGGCCAGAGAAGTGGTG
CAGGTGAGGGAGAGGCTGGCCAGCCGATGTCGAGATGCTAGGATCCGCCTCCTCCTGGCTCAGTGTAATGCCTTGGTGCAGGGGACACTG
ACCCGGGTAGGACTCCTGGACAGGGTGACTCCAGATCAGCTGTTTGTGAGTGTGCAGGATGCAGCTGCTTATGCCCTGGGGAGCCTGTTA
AGGGGCAGTAGCACCAGGAGCGGGAGCCAGGAGGCACTGGGCTGCGGCAAGTGAGGCAGGGGTAAGTGGCTGGAGACCCAGGGAGAGGGG
TTTGGGAAAGGGTCTGAGGAAGATCAAGAAGAAAAGGGTGGGGACGGAATGAATAGTAGATTGAAGACCAAATCAGGGAGCCCGGGCTGA
GCTATGGGTGAGGAACTGAAGAACTCAGATCCCTAAGTAGGTGGGGTACCCCTGAGAGGACTGCCACATTTCATTAAGGAAGAGGGGTGC
CTAATCTATTCCTGACATGTCTCCTCTCTTCTCCAGGAGCTCACTGACCCAAAGATTTGCACCGTGTGGGTCTGACCTCATCATGTGGAG
TGCAGAGGGCCCTGATGACATGTGTGTGATGAGGACCATGACCCTTGAACCCCCTTACCTAACGTAACTAATAAAATGAAGCTGAGAGCT

>81728_81728_1_SHMT2-SLC26A10_SHMT2_chr12_57627893_ENST00000328923_SLC26A10_chr12_58018649_ENST00000379218_length(amino acids)=514AA_BP=0
MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGS
CLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV
KRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKH
ADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARA
MADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDE

--------------------------------------------------------------
>81728_81728_2_SHMT2-SLC26A10_SHMT2_chr12_57627893_ENST00000393827_SLC26A10_chr12_58018649_ENST00000379218_length(transcript)=2225nt_BP=1355nt
ACAATCTGTGGCCTCAGCCCTTGCCAACTCTGCCTCTTCCCCCGCTGACTGGGCCTCTGCAGAGATGTGGGCAGCTGGTCAGGATGGCCA
TTCGGGCTCAGCACAGCAACGCAGCCCAGACTCAGACTGGGGAAGCAAACAGGGGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATC
CTGAGATGTGGGAGTTGCTGCAGAGGGAGAAGGACAGGCAGTGTCGTGGCCTGGAGCTCATTGCCTCAGAGATACTATGGGGGAGCAGAG
GTGGTGGATGAAATTGAGCTGCTGTGCCAGCGCCGGGCCTTGGAAGCCTTTGACCTGGATCCTGCACAGTGGGGAGTCAATGTCCAGCCC
TACTCCGGGTCCCCAGCCAACCTGGCCGTCTACACAGCCCTTCTGCAACCTCACGACCGGATCATGGGGCTGGACCTGCCCGATGGGGGC
CATCTCACCCACGGCTACATGTCTGACGTCAAGCGGATATCAGCCACGTCCATCTTCTTCGAGTCTATGCCCTATAAGCTCAACGGCTTT
AGCTGTTTGTGTGTCTGTCCAGCCCAAAACTGGCCTCATTGACTACAACCAGCTGGCACTGACTGCTCGACTTTTCCGGCCACGGCTCAT
CATAGCTGGCACCAGCGCCTATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTGTGATGAAGTCAAAGCACACCTGCTGGCAGA
CATGGCCCACATCAGTGGCCTGGTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGCACGCGGACATCGTCACCACCACTACTCACAAGAC
TCTTCGAGGGGCCAGGTCAGGGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCCCAAGACTGGCCGGGAGATCCCTTACACATT
TGAGGACCGAATCAACTTTGCCGTGTTCCCATCCCTGCAGGGGGGCCCCCACAATCATGCCATTGCTGCAGTAGCTGTGGCCCTAAAGCA
GGCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCATGGCAGATGCCCTGCTAGAGCGAGGCTACTC
ACTGGTATCAGGTGGTACTGACAACCACCTGGTGCTGGTGGACCTGCGGCCCAAGGGCCTGGATGGAGCTCGGGCTGAGCGGGTGCTAGA
GCTTGTATCCATCACTGCCAACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACCGGGCGGCCTGCGGCTTGGGGCCCCAGCCTT
AACTTCTCGACAGTTCCGTGAGGATGACTTCCGGAGAGTTGTGGACTTTATAGATGAAGGGGTCAACATTGGCTTAGAGGTGAAGAGCAA
GACTGCTCCTCCAGGTCCCGGGGCTCTGCATCCTGAGCTATCCAACACCACTGTACTTTGGGACCCGTGGGCAGTTTCGCTGCAACCTGG
AGTGGCACCTGGGGCTCGGAGAAGGAGAAAAGGAGACTTCAAAGCCAGATGGCCCAATGGTTGCAGTTGCTGAGCCTGTCAGGGTGGTGG
TCCTAGACTTCAGTGGTGTCACCTTTGCAGATGCTGCTGGGGCCAGAGAAGTGGTGCAGGTGAGGGAGAGGCTGGCCAGCCGATGTCGAG
ATGCTAGGATCCGCCTCCTCCTGGCTCAGTGTAATGCCTTGGTGCAGGGGACACTGACCCGGGTAGGACTCCTGGACAGGGTGACTCCAG
ATCAGCTGTTTGTGAGTGTGCAGGATGCAGCTGCTTATGCCCTGGGGAGCCTGTTAAGGGGCAGTAGCACCAGGAGCGGGAGCCAGGAGG
CACTGGGCTGCGGCAAGTGAGGCAGGGGTAAGTGGCTGGAGACCCAGGGAGAGGGGTTTGGGAAAGGGTCTGAGGAAGATCAAGAAGAAA
AGGGTGGGGACGGAATGAATAGTAGATTGAAGACCAAATCAGGGAGCCCGGGCTGAGCTATGGGTGAGGAACTGAAGAACTCAGATCCCT
AAGTAGGTGGGGTACCCCTGAGAGGACTGCCACATTTCATTAAGGAAGAGGGGTGCCTAATCTATTCCTGACATGTCTCCTCTCTTCTCC
AGGAGCTCACTGACCCAAAGATTTGCACCGTGTGGGTCTGACCTCATCATGTGGAGTGCAGAGGGCCCTGATGACATGTGTGTGATGAGG

>81728_81728_2_SHMT2-SLC26A10_SHMT2_chr12_57627893_ENST00000393827_SLC26A10_chr12_58018649_ENST00000379218_length(amino acids)=418AA_BP=0
MGEQRWWMKLSCCASAGPWKPLTWILHSGESMSSPTPGPQPTWPSTQPFCNLTTGSWGWTCPMGAISPTATCLTSSGYQPRPSSSSLCPI
SSTALAVCVSVQPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTT
TTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALL
ERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGL

--------------------------------------------------------------
>81728_81728_3_SHMT2-SLC26A10_SHMT2_chr12_57627893_ENST00000414700_SLC26A10_chr12_58018649_ENST00000379218_length(transcript)=2383nt_BP=1513nt
GCGGACCCGGTGCTGGCAAATGAGCGGAGTTTTCGGCCTGGTCTCACAAGCTGAGCCTTTCCGGCCAGCTCTGAGCCCTGCAGATGATGC
AACCGAGCTTCACTGCTTGCATCAGGCAGGGGTCCCGGCGGCAGTGAGGGCTGGAAGGAGGTGGAACGGCCTCTGCAGAGATGTGGGCAG
CTGGTCAGGATGGCCATTCGGGCTCAGCACAGCAACGCAGCCCAGACTCAGACTGGGGAAGCAAACAGGGGCTGGACAGGCCAGGAGAGC
CTGTCGGACAGTGATCCTGAGATGTGGGAGTTGCTGCAGAGGGAGAAGGACAGGCAGTGTCGTGGCCTGGAGCTCATTGCCTCAGAGAAC
TTCTGCAGCCGAGCTGCGCTGGAGGCCCTGGGGTCCTGTCTGAACAACAAGTACTCGGAGGGTTATCCTGGCAAGAGATACTATGGGGGA
GCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCCAGCGCCGGGCCTTGGAAGCCTTTGACCTGGATCCTGCACAGTGGGGAGTCAATGTC
CAGCCCTACTCCGGGTCCCCAGCCAACCTGGCCGTCTACACAGCCCTTCTGCAACCTCACGACCGGATCATGGGGCTGGACCTGCCCGAT
GGGGGCCATCTCACCCACGGCTACATGTCTGACGTCAAGCGGATATCAGCCACGTCCATCTTCTTCGAGTCTATGCCCTATAAGCTCAAC
CCCAAAACTGGCCTCATTGACTACAACCAGCTGGCACTGACTGCTCGACTTTTCCGGCCACGGCTCATCATAGCTGGCACCAGCGCCTAT
GCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTGTGATGAAGTCAAAGCACACCTGCTGGCAGACATGGCCCACATCAGTGGCCTG
GTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGCACGCGGACATCGTCACCACCACTACTCACAAGACTCTTCGAGGGGCCAGGTCAGGG
CTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCCCAAGACTGGCCGGGAGATCCCTTACACATTTGAGGACCGAATCAACTTTGCC
GTGTTCCCATCCCTGCAGGGGGGCCCCCACAATCATGCCATTGCTGCAGTAGCTGTGGCCCTAAAGCAGGCCTGCACCCCCATGTTCCGG
GAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCATGGCAGATGCCCTGCTAGAGCGAGGCTACTCACTGGTATCAGGTGGTACTGAC
AACCACCTGGTGCTGGTGGACCTGCGGCCCAAGGGCCTGGATGGAGCTCGGGCTGAGCGGGTGCTAGAGCTTGTATCCATCACTGCCAAC
AAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACCGGGCGGCCTGCGGCTTGGGGCCCCAGCCTTAACTTCTCGACAGTTCCGTGAG
GATGACTTCCGGAGAGTTGTGGACTTTATAGATGAAGGGGTCAACATTGGCTTAGAGGTGAAGAGCAAGACTGCTCCTCCAGGTCCCGGG
GCTCTGCATCCTGAGCTATCCAACACCACTGTACTTTGGGACCCGTGGGCAGTTTCGCTGCAACCTGGAGTGGCACCTGGGGCTCGGAGA
AGGAGAAAAGGAGACTTCAAAGCCAGATGGCCCAATGGTTGCAGTTGCTGAGCCTGTCAGGGTGGTGGTCCTAGACTTCAGTGGTGTCAC
CTTTGCAGATGCTGCTGGGGCCAGAGAAGTGGTGCAGGTGAGGGAGAGGCTGGCCAGCCGATGTCGAGATGCTAGGATCCGCCTCCTCCT
GGCTCAGTGTAATGCCTTGGTGCAGGGGACACTGACCCGGGTAGGACTCCTGGACAGGGTGACTCCAGATCAGCTGTTTGTGAGTGTGCA
GGATGCAGCTGCTTATGCCCTGGGGAGCCTGTTAAGGGGCAGTAGCACCAGGAGCGGGAGCCAGGAGGCACTGGGCTGCGGCAAGTGAGG
CAGGGGTAAGTGGCTGGAGACCCAGGGAGAGGGGTTTGGGAAAGGGTCTGAGGAAGATCAAGAAGAAAAGGGTGGGGACGGAATGAATAG
TAGATTGAAGACCAAATCAGGGAGCCCGGGCTGAGCTATGGGTGAGGAACTGAAGAACTCAGATCCCTAAGTAGGTGGGGTACCCCTGAG
AGGACTGCCACATTTCATTAAGGAAGAGGGGTGCCTAATCTATTCCTGACATGTCTCCTCTCTTCTCCAGGAGCTCACTGACCCAAAGAT
TTGCACCGTGTGGGTCTGACCTCATCATGTGGAGTGCAGAGGGCCCTGATGACATGTGTGTGATGAGGACCATGACCCTTGAACCCCCTT

>81728_81728_3_SHMT2-SLC26A10_SHMT2_chr12_57627893_ENST00000414700_SLC26A10_chr12_58018649_ENST00000379218_length(amino acids)=522AA_BP=1
MLASGRGPGGSEGWKEVERPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSR
AALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHL
THGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAK
VIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSL
QVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFR

--------------------------------------------------------------
>81728_81728_4_SHMT2-SLC26A10_SHMT2_chr12_57627893_ENST00000449049_SLC26A10_chr12_58018649_ENST00000379218_length(transcript)=2525nt_BP=1655nt
ATTGCTCTACAATCTGTGGCCTCAGCCCTTGCCAACTCTGCCTCTTCCCCCGCTGACTGGGGTATCAGTTTATGGTGCCCTGCAGGAAGA
CCCTCTTGTTCCTGTGGGTGGGAAGGTTCTGGAATCTCAGTTGCCCTCTCTGGAGTTGGGGAGACATAGGCTTTTGGAGGACAAGCTTTG
CAGAGTGGTTCATGGAGTGAGGTGGTGGGAGATTTCTGAGGTGCGGTGCGGTGAATGGAGCAAATCAGAACCACCCCTTGGACGTTGATC
TCAAGCTTGGCTCCAGAACTGGCTTTTGAAGCCTCTGCAGAGATGTGGGCAGCTGGTCAGGATGGCCATTCGGGCTCAGCACAGCAACGC
AGCCCAGACTCAGACTGGGGAAGCAAACAGGGGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATCCTGAGATGTGGGAGTTGCTGCA
GAGGGAGAAGGACAGGCAGTGTCGTGGCCTGGAGCTCATTGCCTCAGAGAACTTCTGCAGCCGAGCTGCGCTGGAGGCCCTGGGGTCCTG
TCTGAACAACAAGTACTCGGAGGGTTATCCTGGCAAGAGATACTATGGGGGAGCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCCAGCG
CCGGGCCTTGGAAGCCTTTGACCTGGATCCTGCACAGTGGGGAGTCAATGTCCAGCCCTACTCCGGGTCCCCAGCCAACCTGGCCGTCTA
CACAGCCCTTCTGCAACCTCACGACCGGATCATGGGGCTGGACCTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGACGTCAA
GCGGATATCAGCCACGTCCATCTTCTTCGAGTCTATGCCCTATAAGCTCAACCCCAAAACTGGCCTCATTGACTACAACCAGCTGGCACT
GACTGCTCGACTTTTCCGGCCACGGCTCATCATAGCTGGCACCAGCGCCTATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTG
TGATGAAGTCAAAGCACACCTGCTGGCAGACATGGCCCACATCAGTGGCCTGGTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGCACGC
GGACATCGTCACCACCACTACTCACAAGACTCTTCGAGGGGCCAGGTCAGGGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCC
CAAGACTGGCCGGGAGATCCCTTACACATTTGAGGACCGAATCAACTTTGCCGTGTTCCCATCCCTGCAGGGGGGCCCCCACAATCATGC
CATTGCTGCAGTAGCTGTGGCCCTAAAGCAGGCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCAT
GGCAGATGCCCTGCTAGAGCGAGGCTACTCACTGGTATCAGGTGGTACTGACAACCACCTGGTGCTGGTGGACCTGCGGCCCAAGGGCCT
GGATGGAGCTCGGGCTGAGCGGGTGCTAGAGCTTGTATCCATCACTGCCAACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACC
GGGCGGCCTGCGGCTTGGGGCCCCAGCCTTAACTTCTCGACAGTTCCGTGAGGATGACTTCCGGAGAGTTGTGGACTTTATAGATGAAGG
GGTCAACATTGGCTTAGAGGTGAAGAGCAAGACTGCTCCTCCAGGTCCCGGGGCTCTGCATCCTGAGCTATCCAACACCACTGTACTTTG
GGACCCGTGGGCAGTTTCGCTGCAACCTGGAGTGGCACCTGGGGCTCGGAGAAGGAGAAAAGGAGACTTCAAAGCCAGATGGCCCAATGG
TTGCAGTTGCTGAGCCTGTCAGGGTGGTGGTCCTAGACTTCAGTGGTGTCACCTTTGCAGATGCTGCTGGGGCCAGAGAAGTGGTGCAGG
TGAGGGAGAGGCTGGCCAGCCGATGTCGAGATGCTAGGATCCGCCTCCTCCTGGCTCAGTGTAATGCCTTGGTGCAGGGGACACTGACCC
GGGTAGGACTCCTGGACAGGGTGACTCCAGATCAGCTGTTTGTGAGTGTGCAGGATGCAGCTGCTTATGCCCTGGGGAGCCTGTTAAGGG
GCAGTAGCACCAGGAGCGGGAGCCAGGAGGCACTGGGCTGCGGCAAGTGAGGCAGGGGTAAGTGGCTGGAGACCCAGGGAGAGGGGTTTG
GGAAAGGGTCTGAGGAAGATCAAGAAGAAAAGGGTGGGGACGGAATGAATAGTAGATTGAAGACCAAATCAGGGAGCCCGGGCTGAGCTA
TGGGTGAGGAACTGAAGAACTCAGATCCCTAAGTAGGTGGGGTACCCCTGAGAGGACTGCCACATTTCATTAAGGAAGAGGGGTGCCTAA
TCTATTCCTGACATGTCTCCTCTCTTCTCCAGGAGCTCACTGACCCAAAGATTTGCACCGTGTGGGTCTGACCTCATCATGTGGAGTGCA
GAGGGCCCTGATGACATGTGTGTGATGAGGACCATGACCCTTGAACCCCCTTACCTAACGTAACTAATAAAATGAAGCTGAGAGCTTTGG

>81728_81728_4_SHMT2-SLC26A10_SHMT2_chr12_57627893_ENST00000449049_SLC26A10_chr12_58018649_ENST00000379218_length(amino acids)=505AA_BP=2
MKPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEG
YPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIF
FESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTH
KTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERG
YSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVK

--------------------------------------------------------------
>81728_81728_5_SHMT2-SLC26A10_SHMT2_chr12_57627893_ENST00000553474_SLC26A10_chr12_58018649_ENST00000379218_length(transcript)=2317nt_BP=1447nt
ACGGACTGCTAAAGGTCTCCCCTCCCACCTGCATTGCTCTACAATCTGTGGCCTCAGCCCTTGCCAACTCTGCCTCTTCCCCCGCTGACT
GGGCCTCTGCAGAGATGTGGGCAGCTGGTCAGGATGGCCATTCGGGCTCAGCACAGCAACGCAGCCCAGACTCAGACTGGGGAAGCAAAC
AGGGGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATCCTGAGATGTGGGAGTTGCTGCAGAGGGAGAAGGACAGGCAGTGTCGTGGC
CTGGAGCTCATTGCCTCAGAGAACTTCTGCAGCCGAGCTGCGCTGGAGGCCCTGGGGTCCTGTCTGAACAACAAGTACTCGGAGGGTTAT
CCTGGCAAGAGATACTATGGGGGAGCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCCAGCGCCGGGCCTTGGAAGCCTTTGACCTGGAT
CCTGCACAGTGGGGAGTCAATGTCCAGCCCTACTCCGGGTCCCCAGCCAACCTGGCCGTCTACACAGCCCTTCTGCAACCTCACGACCGG
ATCATGGGGCTGGACCTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGACGTCAAGCGGATATCAGCCACGTCCATCTTCTTC
GAGTCTATGCCCTATAAGCTCAACCCCAAAACTGGCCTCATTGACTACAACCAGCTGGCACTGACTGCTCGACTTTTCCGGCCACGGCTC
ATCATAGCTGGCACCAGCGCCTATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTGTGATGAAGTCAAAGCACACCTGCTGGCA
GACATGGCCCACATCAGTGGCCTGGTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGCACGCGGACATCGTCACCACCACTACTCACAAG
ACTCTTCGAGGGGCCAGGTCAGGGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCCCAAGACTGGCCGGGAGATCCCTTACACA
TTTGAGGACCGAATCAACTTTGCCGTGTTCCCATCCCTGCAGGGGGGCCCCCACAATCATGCCATTGCTGCAGTAGCTGTGGCCCTAAAG
CAGGCCTGCACCCCCATGTTCCGGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCATGGCAGATGCCCTGCTAGAGCGAGGCTAC
TCACTGGTATCAGGTGGTACTGACAACCACCTGGTGCTGGTGGACCTGCGGCCCAAGGGCCTGGATGGAGCTCGGGCTGAGCGGGTGCTA
GAGCTTGTATCCATCACTGCCAACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACCGGGCGGCCTGCGGCTTGGGGCCCCAGCC
TTAACTTCTCGACAGTTCCGTGAGGATGACTTCCGGAGAGTTGTGGACTTTATAGATGAAGGGGTCAACATTGGCTTAGAGGTGAAGAGC
AAGACTGCTCCTCCAGGTCCCGGGGCTCTGCATCCTGAGCTATCCAACACCACTGTACTTTGGGACCCGTGGGCAGTTTCGCTGCAACCT
GGAGTGGCACCTGGGGCTCGGAGAAGGAGAAAAGGAGACTTCAAAGCCAGATGGCCCAATGGTTGCAGTTGCTGAGCCTGTCAGGGTGGT
GGTCCTAGACTTCAGTGGTGTCACCTTTGCAGATGCTGCTGGGGCCAGAGAAGTGGTGCAGGTGAGGGAGAGGCTGGCCAGCCGATGTCG
AGATGCTAGGATCCGCCTCCTCCTGGCTCAGTGTAATGCCTTGGTGCAGGGGACACTGACCCGGGTAGGACTCCTGGACAGGGTGACTCC
AGATCAGCTGTTTGTGAGTGTGCAGGATGCAGCTGCTTATGCCCTGGGGAGCCTGTTAAGGGGCAGTAGCACCAGGAGCGGGAGCCAGGA
GGCACTGGGCTGCGGCAAGTGAGGCAGGGGTAAGTGGCTGGAGACCCAGGGAGAGGGGTTTGGGAAAGGGTCTGAGGAAGATCAAGAAGA
AAAGGGTGGGGACGGAATGAATAGTAGATTGAAGACCAAATCAGGGAGCCCGGGCTGAGCTATGGGTGAGGAACTGAAGAACTCAGATCC
CTAAGTAGGTGGGGTACCCCTGAGAGGACTGCCACATTTCATTAAGGAAGAGGGGTGCCTAATCTATTCCTGACATGTCTCCTCTCTTCT
CCAGGAGCTCACTGACCCAAAGATTTGCACCGTGTGGGTCTGACCTCATCATGTGGAGTGCAGAGGGCCCTGATGACATGTGTGTGATGA

>81728_81728_5_SHMT2-SLC26A10_SHMT2_chr12_57627893_ENST00000553474_SLC26A10_chr12_58018649_ENST00000379218_length(amino acids)=523AA_BP=1
MLYNLWPQPLPTLPLPPLTGPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCS
RAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGH
LTHGYMSDVKRISATSIFFESMPYKLNPKTGLIDYNQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAA
KVIPSPFKHADIVTTTTHKTLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYS
LQVLKNARAMADALLERGYSLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDF

--------------------------------------------------------------
>81728_81728_6_SHMT2-SLC26A10_SHMT2_chr12_57627893_ENST00000557487_SLC26A10_chr12_58018649_ENST00000379218_length(transcript)=2295nt_BP=1425nt
CTTCTTCCGACAGCTTGCTGCCCTAGACCAGAGTTGGTGGCTGGACCTCCTGCGACTTCCGAGTTGCGATGCTGTACTTCTCTTTGTTTT
GGGCGGCTCGGCCTCTGCAGAGATGTGGGCAGCTGGTCAGGATGGCCATTCGGGCTCAGCACAGCAACGCAGCCCAGACTCAGACTGGGG
AAGCAAACAGGGGCTGGACAGGCCAGGAGAGCCTGTCGGACAGTGATCCTGAGATGTGGGAGTTGCTGCAGAGGGAGAAGGACAGGCAGT
GTCGTGGCCTGGAGCTCATTGCCTCAGAGAACTTCTGCAGCCGAGCTGCGCTGGAGGCCCTGGGGTCCTGTCTGAACAACAAGTACTCGG
AGGGTTATCCTGGCAAGAGATACTATGGGGGAGCAGAGGTGGTGGATGAAATTGAGCTGCTGTGCCAGCGCCGGGCCTTGGAAGCCTTTG
ACCTGGATCCTGCACAGTGGGGAGTCAATGTCCAGCCCTACTCCGGGTCCCCAGCCAACCTGGCCGTCTACACAGCCCTTCTGCAACCTC
ACGACCGGATCATGGGGCTGGACCTGCCCGATGGGGGCCATCTCACCCACGGCTACATGTCTGACGTCAAGCGGATATCAGCCACGTCCA
TCTTCTTCGAGTCTATGCCCTATAAGCTCAACCTGGCACTGACTGCTCGACTTTTCCGGCCACGGCTCATCATAGCTGGCACCAGCGCCT
ATGCTCGCCTCATTGACTACGCCCGCATGAGAGAGGTGTGTGATGAAGTCAAAGCACACCTGCTGGCAGACATGGCCCACATCAGTGGCC
TGGTGGCTGCCAAGGTGATTCCCTCGCCTTTCAAGCACGCGGACATCGTCACCACCACTACTCACAAGACTCTTCGAGGGGCCAGGTCAG
GGCTCATCTTCTACCGGAAAGGGGTGAAGGCTGTGGACCCCAAGACTGGCCGGGAGATCCCTTACACATTTGAGGACCGAATCAACTTTG
CCGTGTTCCCATCCCTGCAGGGGGGCCCCCACAATCATGCCATTGCTGCAGTAGCTGTGGCCCTAAAGCAGGCCTGCACCCCCATGTTCC
GGGAGTACTCCCTGCAGGTTCTGAAGAATGCTCGGGCCATGGCAGATGCCCTGCTAGAGCGAGGCTACTCACTGGTATCAGGTGGTACTG
ACAACCACCTGGTGCTGGTGGACCTGCGGCCCAAGGGCCTGGATGGAGCTCGGGCTGAGCGGGTGCTAGAGCTTGTATCCATCACTGCCA
ACAAGAACACCTGTCCTGGAGACCGAAGTGCCATCACACCGGGCGGCCTGCGGCTTGGGGCCCCAGCCTTAACTTCTCGACAGTTCCGTG
AGGATGACTTCCGGAGAGTTGTGGACTTTATAGATGAAGGGGTCAACATTGGCTTAGAGGTGAAGAGCAAGACTGCTCCTCCAGGTCCCG
GGGCTCTGCATCCTGAGCTATCCAACACCACTGTACTTTGGGACCCGTGGGCAGTTTCGCTGCAACCTGGAGTGGCACCTGGGGCTCGGA
GAAGGAGAAAAGGAGACTTCAAAGCCAGATGGCCCAATGGTTGCAGTTGCTGAGCCTGTCAGGGTGGTGGTCCTAGACTTCAGTGGTGTC
ACCTTTGCAGATGCTGCTGGGGCCAGAGAAGTGGTGCAGGTGAGGGAGAGGCTGGCCAGCCGATGTCGAGATGCTAGGATCCGCCTCCTC
CTGGCTCAGTGTAATGCCTTGGTGCAGGGGACACTGACCCGGGTAGGACTCCTGGACAGGGTGACTCCAGATCAGCTGTTTGTGAGTGTG
CAGGATGCAGCTGCTTATGCCCTGGGGAGCCTGTTAAGGGGCAGTAGCACCAGGAGCGGGAGCCAGGAGGCACTGGGCTGCGGCAAGTGA
GGCAGGGGTAAGTGGCTGGAGACCCAGGGAGAGGGGTTTGGGAAAGGGTCTGAGGAAGATCAAGAAGAAAAGGGTGGGGACGGAATGAAT
AGTAGATTGAAGACCAAATCAGGGAGCCCGGGCTGAGCTATGGGTGAGGAACTGAAGAACTCAGATCCCTAAGTAGGTGGGGTACCCCTG
AGAGGACTGCCACATTTCATTAAGGAAGAGGGGTGCCTAATCTATTCCTGACATGTCTCCTCTCTTCTCCAGGAGCTCACTGACCCAAAG
ATTTGCACCGTGTGGGTCTGACCTCATCATGTGGAGTGCAGAGGGCCCTGATGACATGTGTGTGATGAGGACCATGACCCTTGAACCCCC

>81728_81728_6_SHMT2-SLC26A10_SHMT2_chr12_57627893_ENST00000557487_SLC26A10_chr12_58018649_ENST00000379218_length(amino acids)=504AA_BP=0
MLYFSLFWAARPLQRCGQLVRMAIRAQHSNAAQTQTGEANRGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGS
CLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAVYTALLQPHDRIMGLDLPDGGHLTHGYMSDV
KRISATSIFFESMPYKLNLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVKAHLLADMAHISGLVAAKVIPSPFKHADIVTTTTHK
TLRGARSGLIFYRKGVKAVDPKTGREIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLKNARAMADALLERGY
SLVSGGTDNHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SHMT2-SLC26A10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SHMT2-SLC26A10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SHMT2-SLC26A10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource