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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SHPRH-RCL1 (FusionGDB2 ID:81748)

Fusion Gene Summary for SHPRH-RCL1

check button Fusion gene summary
Fusion gene informationFusion gene name: SHPRH-RCL1
Fusion gene ID: 81748
HgeneTgene
Gene symbol

SHPRH

RCL1

Gene ID

257218

10171

Gene nameSNF2 histone linker PHD RING helicaseRNA terminal phosphate cyclase like 1
SynonymsbA545I5.2RNAC|RPCL1
Cytomap

6q24.3

9p24.1

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase SHPRH2610103K11RikRING-type E3 ubiquitin transferase SHPRHSNF2 histone linker PHD RING helicase, E3 ubiquitin protein ligaseSNF2, histone-linker, PHD and RING finger domain-containing helicaseRNA 3'-terminal phosphate cyclase-like proteinRNA cyclase homolog
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000275233, ENST00000367503, 
ENST00000367505, ENST00000438092, 
ENST00000381732, ENST00000445485, 
ENST00000381750, ENST00000381728, 
ENST00000381730, ENST00000448872, 
Fusion gene scores* DoF score4 X 3 X 3=367 X 8 X 6=336
# samples 49
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SHPRH [Title/Abstract] AND RCL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSHPRH(146273485)-RCL1(4860125), # samples:3
Anticipated loss of major functional domain due to fusion event.SHPRH-RCL1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
SHPRH-RCL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SHPRH-RCL1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
SHPRH-RCL1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSHPRH

GO:0000209

protein polyubiquitination

17108083

HgeneSHPRH

GO:0006974

cellular response to DNA damage stimulus

25023518


check buttonFusion gene breakpoints across SHPRH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RCL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GC-A4ZW-01ASHPRHchr6

146273485

-RCL1chr9

4860125

+


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Fusion Gene ORF analysis for SHPRH-RCL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000275233ENST00000381732SHPRHchr6

146273485

-RCL1chr9

4860125

+
5CDS-intronENST00000275233ENST00000445485SHPRHchr6

146273485

-RCL1chr9

4860125

+
5CDS-intronENST00000367503ENST00000381732SHPRHchr6

146273485

-RCL1chr9

4860125

+
5CDS-intronENST00000367503ENST00000445485SHPRHchr6

146273485

-RCL1chr9

4860125

+
5CDS-intronENST00000367505ENST00000381732SHPRHchr6

146273485

-RCL1chr9

4860125

+
5CDS-intronENST00000367505ENST00000445485SHPRHchr6

146273485

-RCL1chr9

4860125

+
5CDS-intronENST00000438092ENST00000381732SHPRHchr6

146273485

-RCL1chr9

4860125

+
5CDS-intronENST00000438092ENST00000445485SHPRHchr6

146273485

-RCL1chr9

4860125

+
Frame-shiftENST00000275233ENST00000381750SHPRHchr6

146273485

-RCL1chr9

4860125

+
Frame-shiftENST00000367503ENST00000381750SHPRHchr6

146273485

-RCL1chr9

4860125

+
Frame-shiftENST00000367505ENST00000381750SHPRHchr6

146273485

-RCL1chr9

4860125

+
Frame-shiftENST00000438092ENST00000381750SHPRHchr6

146273485

-RCL1chr9

4860125

+
In-frameENST00000275233ENST00000381728SHPRHchr6

146273485

-RCL1chr9

4860125

+
In-frameENST00000275233ENST00000381730SHPRHchr6

146273485

-RCL1chr9

4860125

+
In-frameENST00000275233ENST00000448872SHPRHchr6

146273485

-RCL1chr9

4860125

+
In-frameENST00000367503ENST00000381728SHPRHchr6

146273485

-RCL1chr9

4860125

+
In-frameENST00000367503ENST00000381730SHPRHchr6

146273485

-RCL1chr9

4860125

+
In-frameENST00000367503ENST00000448872SHPRHchr6

146273485

-RCL1chr9

4860125

+
In-frameENST00000367505ENST00000381728SHPRHchr6

146273485

-RCL1chr9

4860125

+
In-frameENST00000367505ENST00000381730SHPRHchr6

146273485

-RCL1chr9

4860125

+
In-frameENST00000367505ENST00000448872SHPRHchr6

146273485

-RCL1chr9

4860125

+
In-frameENST00000438092ENST00000381728SHPRHchr6

146273485

-RCL1chr9

4860125

+
In-frameENST00000438092ENST00000381730SHPRHchr6

146273485

-RCL1chr9

4860125

+
In-frameENST00000438092ENST00000448872SHPRHchr6

146273485

-RCL1chr9

4860125

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367505SHPRHchr6146273485-ENST00000381730RCL1chr94860125+13761028611032323
ENST00000367505SHPRHchr6146273485-ENST00000381728RCL1chr94860125+11961028611032323
ENST00000367505SHPRHchr6146273485-ENST00000448872RCL1chr94860125+13401028611032323
ENST00000367503SHPRHchr6146273485-ENST00000381730RCL1chr94860125+151011623631166267
ENST00000367503SHPRHchr6146273485-ENST00000381728RCL1chr94860125+133011623631166267
ENST00000367503SHPRHchr6146273485-ENST00000448872RCL1chr94860125+147411623631166267
ENST00000438092SHPRHchr6146273485-ENST00000381730RCL1chr94860125+151011623631166267
ENST00000438092SHPRHchr6146273485-ENST00000381728RCL1chr94860125+133011623631166267
ENST00000438092SHPRHchr6146273485-ENST00000448872RCL1chr94860125+147411623631166267
ENST00000275233SHPRHchr6146273485-ENST00000381730RCL1chr94860125+151011623631166267
ENST00000275233SHPRHchr6146273485-ENST00000381728RCL1chr94860125+133011623631166267
ENST00000275233SHPRHchr6146273485-ENST00000448872RCL1chr94860125+147411623631166267

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367505ENST00000381730SHPRHchr6146273485-RCL1chr94860125+0.0055575460.9944424
ENST00000367505ENST00000381728SHPRHchr6146273485-RCL1chr94860125+0.0051121380.9948879
ENST00000367505ENST00000448872SHPRHchr6146273485-RCL1chr94860125+0.0060938840.9939061
ENST00000367503ENST00000381730SHPRHchr6146273485-RCL1chr94860125+0.0047834380.9952166
ENST00000367503ENST00000381728SHPRHchr6146273485-RCL1chr94860125+0.0041471420.9958528
ENST00000367503ENST00000448872SHPRHchr6146273485-RCL1chr94860125+0.0051805530.99481946
ENST00000438092ENST00000381730SHPRHchr6146273485-RCL1chr94860125+0.0047834380.9952166
ENST00000438092ENST00000381728SHPRHchr6146273485-RCL1chr94860125+0.0041471420.9958528
ENST00000438092ENST00000448872SHPRHchr6146273485-RCL1chr94860125+0.0051805530.99481946
ENST00000275233ENST00000381730SHPRHchr6146273485-RCL1chr94860125+0.0047834380.9952166
ENST00000275233ENST00000381728SHPRHchr6146273485-RCL1chr94860125+0.0041471420.9958528
ENST00000275233ENST00000448872SHPRHchr6146273485-RCL1chr94860125+0.0051805530.99481946

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Fusion Genomic Features for SHPRH-RCL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SHPRHchr6146273484-RCL1chr94860124+5.79E-050.99994206
SHPRHchr6146273484-RCL1chr94860124+5.79E-050.99994206

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SHPRH-RCL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:146273485/chr9:4860125)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSHPRHchr6:146273485chr9:4860125ENST00000275233-3301514_16722541684.0DomainHelicase C-terminal
HgeneSHPRHchr6:146273485chr9:4860125ENST00000275233-330307_3892541684.0DomainHelicase ATP-binding%3B first part
HgeneSHPRHchr6:146273485chr9:4860125ENST00000275233-330438_5122541684.0DomainH15
HgeneSHPRHchr6:146273485chr9:4860125ENST00000275233-330710_8682541684.0DomainHelicase ATP-binding%3B second part
HgeneSHPRHchr6:146273485chr9:4860125ENST00000367505-3301514_16722541684.0DomainHelicase C-terminal
HgeneSHPRHchr6:146273485chr9:4860125ENST00000367505-330307_3892541684.0DomainHelicase ATP-binding%3B first part
HgeneSHPRHchr6:146273485chr9:4860125ENST00000367505-330438_5122541684.0DomainH15
HgeneSHPRHchr6:146273485chr9:4860125ENST00000367505-330710_8682541684.0DomainHelicase ATP-binding%3B second part
HgeneSHPRHchr6:146273485chr9:4860125ENST00000438092-3301514_16722541660.0DomainHelicase C-terminal
HgeneSHPRHchr6:146273485chr9:4860125ENST00000438092-330307_3892541660.0DomainHelicase ATP-binding%3B first part
HgeneSHPRHchr6:146273485chr9:4860125ENST00000438092-330438_5122541660.0DomainH15
HgeneSHPRHchr6:146273485chr9:4860125ENST00000438092-330710_8682541660.0DomainHelicase ATP-binding%3B second part
HgeneSHPRHchr6:146273485chr9:4860125ENST00000275233-330819_8222541684.0MotifNote=DEAQ box
HgeneSHPRHchr6:146273485chr9:4860125ENST00000367505-330819_8222541684.0MotifNote=DEAQ box
HgeneSHPRHchr6:146273485chr9:4860125ENST00000438092-330819_8222541660.0MotifNote=DEAQ box
HgeneSHPRHchr6:146273485chr9:4860125ENST00000275233-330373_3802541684.0Nucleotide bindingATP
HgeneSHPRHchr6:146273485chr9:4860125ENST00000367505-330373_3802541684.0Nucleotide bindingATP
HgeneSHPRHchr6:146273485chr9:4860125ENST00000438092-330373_3802541660.0Nucleotide bindingATP
HgeneSHPRHchr6:146273485chr9:4860125ENST00000275233-3301432_14792541684.0Zinc fingerRING-type
HgeneSHPRHchr6:146273485chr9:4860125ENST00000275233-330658_7092541684.0Zinc fingerNote=PHD-type
HgeneSHPRHchr6:146273485chr9:4860125ENST00000367505-3301432_14792541684.0Zinc fingerRING-type
HgeneSHPRHchr6:146273485chr9:4860125ENST00000367505-330658_7092541684.0Zinc fingerNote=PHD-type
HgeneSHPRHchr6:146273485chr9:4860125ENST00000438092-3301432_14792541660.0Zinc fingerRING-type
HgeneSHPRHchr6:146273485chr9:4860125ENST00000438092-330658_7092541660.0Zinc fingerNote=PHD-type


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Fusion Gene Sequence for SHPRH-RCL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81748_81748_1_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000275233_RCL1_chr9_4860125_ENST00000381728_length(transcript)=1330nt_BP=1162nt
GTCTTTGGCCTCCGGGACCAGGGAGGGAGGACGCTGGTTGTCCTGGAGCCCGGGAAGCTCAAGGGCTGAGAGGGAGCCGCTGCGCGAGTC
TTCCCCACCTCTTCCCGATCCCGGACTAGCGAACTTCGGACCACCACGTCCCTCCGGGGATAAAGTGGGGTCGTGGGAAAGGAGGCTGTG
CTTCTCCTCATGCACTGGGGCCTGCGGTGTTTGTCTCGAGCGTCCAACACACTAGGATCCGGGAGTCCGTCGTCACGCTCCTTGGCCTCG
CGGTCGCTTGTTTGCTCGGCCTGCTGGGAGCGATCCGGCGCTGACAGCCCCGCTCAGACTCCGGGAGCCGCTTGTGGGTCTTTCGGAAGA
TAACTGAAGTTCACAGTTACCAGCCAAGAAAACTTGAAAATGAGCAGCCGACGGAAACGTGCTCCTCCAGTGAGGGTAGATGAGGAAAAG
AGGCAGCAGCTTCATTGGAATATGCATGAGGACAGAAGGAATGAACCTATCATCATAAGTGATGATGACGAGCAGCCCTGCCCAGGTTCA
GATACCTCTTCTGCTCATTATATCATTCTAAGTGATAGTCTAAAGGAAGAAGTGGCTCACAGAGATAAGAAGAGGTGTTCAAAAGTGGTG
AGCTTCTCAAAACCAATTGAAAAAGAAGAGACTGTTGGTATTTTTTCCCCTTTGTCTGTAAAGTTAAATATTGTGATTTCTCCCTATCAT
TTTGATAATTCCTGGAAAGCATTTCTAGGAGAATTAACTCTTCAGCTTCTTCCTGCACAGAGTTTAATTGAAAATTTTTCCGAAAGGAGT
ATTACATTGATGAGTTCAGAGTCAAGCAATCAGTTCCTGATTTATGTTCATTCAAAAGGTGAAGATGTAGAGAAACAAAAAAAAGAACCG
ATGAGTATTTGTGACAAGGGTATTCTGGTGGAGTCATCCTTCAGTGGTGAAATGTTAGAAGATTTGGGGTGGCTACAAAAGAAGAGAAGA
ATAAAACTCTATCAGAAACCAGAAGGAAATCACATTATCAAGGTTGGAATTTATCTTTTGGAAGCTGGCCTAGCAAAACTAGACTTCTTG
AGTGATGCAAATTCAAGAATGAAAAAGTTCAATCAGCTCATGAAGAAAGTAATGGAAAAGTTACACAATTCTATTATTCCAGGATAGAAT
TTTTGCGGCATTTGAAGAGCTTTTTCCAGATTATGTTTAAAATTGAAACCAAGCCATGTGGTGAAGAACTCAAGGGTGGGGATAAAGTGC

>81748_81748_1_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000275233_RCL1_chr9_4860125_ENST00000381728_length(amino acids)=267AA_BP=
MKFTVTSQENLKMSSRRKRAPPVRVDEEKRQQLHWNMHEDRRNEPIIISDDDEQPCPGSDTSSAHYIILSDSLKEEVAHRDKKRCSKVVS
FSKPIEKEETVGIFSPLSVKLNIVISPYHFDNSWKAFLGELTLQLLPAQSLIENFSERSITLMSSESSNQFLIYVHSKGEDVEKQKKEPM

--------------------------------------------------------------
>81748_81748_2_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000275233_RCL1_chr9_4860125_ENST00000381730_length(transcript)=1510nt_BP=1162nt
GTCTTTGGCCTCCGGGACCAGGGAGGGAGGACGCTGGTTGTCCTGGAGCCCGGGAAGCTCAAGGGCTGAGAGGGAGCCGCTGCGCGAGTC
TTCCCCACCTCTTCCCGATCCCGGACTAGCGAACTTCGGACCACCACGTCCCTCCGGGGATAAAGTGGGGTCGTGGGAAAGGAGGCTGTG
CTTCTCCTCATGCACTGGGGCCTGCGGTGTTTGTCTCGAGCGTCCAACACACTAGGATCCGGGAGTCCGTCGTCACGCTCCTTGGCCTCG
CGGTCGCTTGTTTGCTCGGCCTGCTGGGAGCGATCCGGCGCTGACAGCCCCGCTCAGACTCCGGGAGCCGCTTGTGGGTCTTTCGGAAGA
TAACTGAAGTTCACAGTTACCAGCCAAGAAAACTTGAAAATGAGCAGCCGACGGAAACGTGCTCCTCCAGTGAGGGTAGATGAGGAAAAG
AGGCAGCAGCTTCATTGGAATATGCATGAGGACAGAAGGAATGAACCTATCATCATAAGTGATGATGACGAGCAGCCCTGCCCAGGTTCA
GATACCTCTTCTGCTCATTATATCATTCTAAGTGATAGTCTAAAGGAAGAAGTGGCTCACAGAGATAAGAAGAGGTGTTCAAAAGTGGTG
AGCTTCTCAAAACCAATTGAAAAAGAAGAGACTGTTGGTATTTTTTCCCCTTTGTCTGTAAAGTTAAATATTGTGATTTCTCCCTATCAT
TTTGATAATTCCTGGAAAGCATTTCTAGGAGAATTAACTCTTCAGCTTCTTCCTGCACAGAGTTTAATTGAAAATTTTTCCGAAAGGAGT
ATTACATTGATGAGTTCAGAGTCAAGCAATCAGTTCCTGATTTATGTTCATTCAAAAGGTGAAGATGTAGAGAAACAAAAAAAAGAACCG
ATGAGTATTTGTGACAAGGGTATTCTGGTGGAGTCATCCTTCAGTGGTGAAATGTTAGAAGATTTGGGGTGGCTACAAAAGAAGAGAAGA
ATAAAACTCTATCAGAAACCAGAAGGAAATCACATTATCAAGGTTGGAATTTATCTTTTGGAAGCTGGCCTAGCAAAACTAGACTTCTTG
AGTGATGCAAATTCAAGAATGAAAAAGTTCAATCAGCTCATGAAGAAAGTAATGGAAAAGTTACACAATTCTATTATTCCAGGATAGAAT
TTTTGCGGCATTTGAAGAGCTTTTTCCAGATTATGTTTAAAATTGAAACCAAGCCATGTGGTGAAGAACTCAAGGGTGGGGATAAAGTGC
TGATGACCTGTGTTGGCATTGGTTTCTCCAACCTTAGCAAGACCCTCAAGTGATAACCATCACAAGATAAGGCCCCAATGCCTACAGACA
AAGCAGAAGCTGCCACGGACACCAATGGGACCAAGTCCAAATGGATTAATCCAGGACAGAATAGCCACTTGCTTAATTTTCTGTGAAGAA

>81748_81748_2_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000275233_RCL1_chr9_4860125_ENST00000381730_length(amino acids)=267AA_BP=
MKFTVTSQENLKMSSRRKRAPPVRVDEEKRQQLHWNMHEDRRNEPIIISDDDEQPCPGSDTSSAHYIILSDSLKEEVAHRDKKRCSKVVS
FSKPIEKEETVGIFSPLSVKLNIVISPYHFDNSWKAFLGELTLQLLPAQSLIENFSERSITLMSSESSNQFLIYVHSKGEDVEKQKKEPM

--------------------------------------------------------------
>81748_81748_3_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000275233_RCL1_chr9_4860125_ENST00000448872_length(transcript)=1474nt_BP=1162nt
GTCTTTGGCCTCCGGGACCAGGGAGGGAGGACGCTGGTTGTCCTGGAGCCCGGGAAGCTCAAGGGCTGAGAGGGAGCCGCTGCGCGAGTC
TTCCCCACCTCTTCCCGATCCCGGACTAGCGAACTTCGGACCACCACGTCCCTCCGGGGATAAAGTGGGGTCGTGGGAAAGGAGGCTGTG
CTTCTCCTCATGCACTGGGGCCTGCGGTGTTTGTCTCGAGCGTCCAACACACTAGGATCCGGGAGTCCGTCGTCACGCTCCTTGGCCTCG
CGGTCGCTTGTTTGCTCGGCCTGCTGGGAGCGATCCGGCGCTGACAGCCCCGCTCAGACTCCGGGAGCCGCTTGTGGGTCTTTCGGAAGA
TAACTGAAGTTCACAGTTACCAGCCAAGAAAACTTGAAAATGAGCAGCCGACGGAAACGTGCTCCTCCAGTGAGGGTAGATGAGGAAAAG
AGGCAGCAGCTTCATTGGAATATGCATGAGGACAGAAGGAATGAACCTATCATCATAAGTGATGATGACGAGCAGCCCTGCCCAGGTTCA
GATACCTCTTCTGCTCATTATATCATTCTAAGTGATAGTCTAAAGGAAGAAGTGGCTCACAGAGATAAGAAGAGGTGTTCAAAAGTGGTG
AGCTTCTCAAAACCAATTGAAAAAGAAGAGACTGTTGGTATTTTTTCCCCTTTGTCTGTAAAGTTAAATATTGTGATTTCTCCCTATCAT
TTTGATAATTCCTGGAAAGCATTTCTAGGAGAATTAACTCTTCAGCTTCTTCCTGCACAGAGTTTAATTGAAAATTTTTCCGAAAGGAGT
ATTACATTGATGAGTTCAGAGTCAAGCAATCAGTTCCTGATTTATGTTCATTCAAAAGGTGAAGATGTAGAGAAACAAAAAAAAGAACCG
ATGAGTATTTGTGACAAGGGTATTCTGGTGGAGTCATCCTTCAGTGGTGAAATGTTAGAAGATTTGGGGTGGCTACAAAAGAAGAGAAGA
ATAAAACTCTATCAGAAACCAGAAGGAAATCACATTATCAAGGTTGGAATTTATCTTTTGGAAGCTGGCCTAGCAAAACTAGACTTCTTG
AGTGATGCAAATTCAAGAATGAAAAAGTTCAATCAGCTCATGAAGAAAGTAATGGAAAAGTTACACAATTCTATTATTCCAGGATAGAAT
TTTTGCGGCATTTGAAGAGCTTTTTCCAGATTATGTTTAAAATTGAAACCAAGCCATGTGGTGAAGAACTCAAGGGTGGGGATAAAGTGC
TGATGACCTGTGTTGGCATTGGTTTCTCCAACCTTAGCAAGACCCTCAAGTGATAACCATCACAAGATAAGGCCCCAATGCCTACAGACA
AAGCAGAAGCTGCCACGGACACCAATGGGACCAAGTCCAAATGGATTAATCCAGGACAGAATAGCCACTTGCTTAATTTTCTGTGAAGAA

>81748_81748_3_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000275233_RCL1_chr9_4860125_ENST00000448872_length(amino acids)=267AA_BP=
MKFTVTSQENLKMSSRRKRAPPVRVDEEKRQQLHWNMHEDRRNEPIIISDDDEQPCPGSDTSSAHYIILSDSLKEEVAHRDKKRCSKVVS
FSKPIEKEETVGIFSPLSVKLNIVISPYHFDNSWKAFLGELTLQLLPAQSLIENFSERSITLMSSESSNQFLIYVHSKGEDVEKQKKEPM

--------------------------------------------------------------
>81748_81748_4_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000367503_RCL1_chr9_4860125_ENST00000381728_length(transcript)=1330nt_BP=1162nt
GTCTTTGGCCTCCGGGACCAGGGAGGGAGGACGCTGGTTGTCCTGGAGCCCGGGAAGCTCAAGGGCTGAGAGGGAGCCGCTGCGCGAGTC
TTCCCCACCTCTTCCCGATCCCGGACTAGCGAACTTCGGACCACCACGTCCCTCCGGGGATAAAGTGGGGTCGTGGGAAAGGAGGCTGTG
CTTCTCCTCATGCACTGGGGCCTGCGGTGTTTGTCTCGAGCGTCCAACACACTAGGATCCGGGAGTCCGTCGTCACGCTCCTTGGCCTCG
CGGTCGCTTGTTTGCTCGGCCTGCTGGGAGCGATCCGGCGCTGACAGCCCCGCTCAGACTCCGGGAGCCGCTTGTGGGTCTTTCGGAAGA
TAACTGAAGTTCACAGTTACCAGCCAAGAAAACTTGAAAATGAGCAGCCGACGGAAACGTGCTCCTCCAGTGAGGGTAGATGAGGAAAAG
AGGCAGCAGCTTCATTGGAATATGCATGAGGACAGAAGGAATGAACCTATCATCATAAGTGATGATGACGAGCAGCCCTGCCCAGGTTCA
GATACCTCTTCTGCTCATTATATCATTCTAAGTGATAGTCTAAAGGAAGAAGTGGCTCACAGAGATAAGAAGAGGTGTTCAAAAGTGGTG
AGCTTCTCAAAACCAATTGAAAAAGAAGAGACTGTTGGTATTTTTTCCCCTTTGTCTGTAAAGTTAAATATTGTGATTTCTCCCTATCAT
TTTGATAATTCCTGGAAAGCATTTCTAGGAGAATTAACTCTTCAGCTTCTTCCTGCACAGAGTTTAATTGAAAATTTTTCCGAAAGGAGT
ATTACATTGATGAGTTCAGAGTCAAGCAATCAGTTCCTGATTTATGTTCATTCAAAAGGTGAAGATGTAGAGAAACAAAAAAAAGAACCG
ATGAGTATTTGTGACAAGGGTATTCTGGTGGAGTCATCCTTCAGTGGTGAAATGTTAGAAGATTTGGGGTGGCTACAAAAGAAGAGAAGA
ATAAAACTCTATCAGAAACCAGAAGGAAATCACATTATCAAGGTTGGAATTTATCTTTTGGAAGCTGGCCTAGCAAAACTAGACTTCTTG
AGTGATGCAAATTCAAGAATGAAAAAGTTCAATCAGCTCATGAAGAAAGTAATGGAAAAGTTACACAATTCTATTATTCCAGGATAGAAT
TTTTGCGGCATTTGAAGAGCTTTTTCCAGATTATGTTTAAAATTGAAACCAAGCCATGTGGTGAAGAACTCAAGGGTGGGGATAAAGTGC

>81748_81748_4_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000367503_RCL1_chr9_4860125_ENST00000381728_length(amino acids)=267AA_BP=
MKFTVTSQENLKMSSRRKRAPPVRVDEEKRQQLHWNMHEDRRNEPIIISDDDEQPCPGSDTSSAHYIILSDSLKEEVAHRDKKRCSKVVS
FSKPIEKEETVGIFSPLSVKLNIVISPYHFDNSWKAFLGELTLQLLPAQSLIENFSERSITLMSSESSNQFLIYVHSKGEDVEKQKKEPM

--------------------------------------------------------------
>81748_81748_5_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000367503_RCL1_chr9_4860125_ENST00000381730_length(transcript)=1510nt_BP=1162nt
GTCTTTGGCCTCCGGGACCAGGGAGGGAGGACGCTGGTTGTCCTGGAGCCCGGGAAGCTCAAGGGCTGAGAGGGAGCCGCTGCGCGAGTC
TTCCCCACCTCTTCCCGATCCCGGACTAGCGAACTTCGGACCACCACGTCCCTCCGGGGATAAAGTGGGGTCGTGGGAAAGGAGGCTGTG
CTTCTCCTCATGCACTGGGGCCTGCGGTGTTTGTCTCGAGCGTCCAACACACTAGGATCCGGGAGTCCGTCGTCACGCTCCTTGGCCTCG
CGGTCGCTTGTTTGCTCGGCCTGCTGGGAGCGATCCGGCGCTGACAGCCCCGCTCAGACTCCGGGAGCCGCTTGTGGGTCTTTCGGAAGA
TAACTGAAGTTCACAGTTACCAGCCAAGAAAACTTGAAAATGAGCAGCCGACGGAAACGTGCTCCTCCAGTGAGGGTAGATGAGGAAAAG
AGGCAGCAGCTTCATTGGAATATGCATGAGGACAGAAGGAATGAACCTATCATCATAAGTGATGATGACGAGCAGCCCTGCCCAGGTTCA
GATACCTCTTCTGCTCATTATATCATTCTAAGTGATAGTCTAAAGGAAGAAGTGGCTCACAGAGATAAGAAGAGGTGTTCAAAAGTGGTG
AGCTTCTCAAAACCAATTGAAAAAGAAGAGACTGTTGGTATTTTTTCCCCTTTGTCTGTAAAGTTAAATATTGTGATTTCTCCCTATCAT
TTTGATAATTCCTGGAAAGCATTTCTAGGAGAATTAACTCTTCAGCTTCTTCCTGCACAGAGTTTAATTGAAAATTTTTCCGAAAGGAGT
ATTACATTGATGAGTTCAGAGTCAAGCAATCAGTTCCTGATTTATGTTCATTCAAAAGGTGAAGATGTAGAGAAACAAAAAAAAGAACCG
ATGAGTATTTGTGACAAGGGTATTCTGGTGGAGTCATCCTTCAGTGGTGAAATGTTAGAAGATTTGGGGTGGCTACAAAAGAAGAGAAGA
ATAAAACTCTATCAGAAACCAGAAGGAAATCACATTATCAAGGTTGGAATTTATCTTTTGGAAGCTGGCCTAGCAAAACTAGACTTCTTG
AGTGATGCAAATTCAAGAATGAAAAAGTTCAATCAGCTCATGAAGAAAGTAATGGAAAAGTTACACAATTCTATTATTCCAGGATAGAAT
TTTTGCGGCATTTGAAGAGCTTTTTCCAGATTATGTTTAAAATTGAAACCAAGCCATGTGGTGAAGAACTCAAGGGTGGGGATAAAGTGC
TGATGACCTGTGTTGGCATTGGTTTCTCCAACCTTAGCAAGACCCTCAAGTGATAACCATCACAAGATAAGGCCCCAATGCCTACAGACA
AAGCAGAAGCTGCCACGGACACCAATGGGACCAAGTCCAAATGGATTAATCCAGGACAGAATAGCCACTTGCTTAATTTTCTGTGAAGAA

>81748_81748_5_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000367503_RCL1_chr9_4860125_ENST00000381730_length(amino acids)=267AA_BP=
MKFTVTSQENLKMSSRRKRAPPVRVDEEKRQQLHWNMHEDRRNEPIIISDDDEQPCPGSDTSSAHYIILSDSLKEEVAHRDKKRCSKVVS
FSKPIEKEETVGIFSPLSVKLNIVISPYHFDNSWKAFLGELTLQLLPAQSLIENFSERSITLMSSESSNQFLIYVHSKGEDVEKQKKEPM

--------------------------------------------------------------
>81748_81748_6_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000367503_RCL1_chr9_4860125_ENST00000448872_length(transcript)=1474nt_BP=1162nt
GTCTTTGGCCTCCGGGACCAGGGAGGGAGGACGCTGGTTGTCCTGGAGCCCGGGAAGCTCAAGGGCTGAGAGGGAGCCGCTGCGCGAGTC
TTCCCCACCTCTTCCCGATCCCGGACTAGCGAACTTCGGACCACCACGTCCCTCCGGGGATAAAGTGGGGTCGTGGGAAAGGAGGCTGTG
CTTCTCCTCATGCACTGGGGCCTGCGGTGTTTGTCTCGAGCGTCCAACACACTAGGATCCGGGAGTCCGTCGTCACGCTCCTTGGCCTCG
CGGTCGCTTGTTTGCTCGGCCTGCTGGGAGCGATCCGGCGCTGACAGCCCCGCTCAGACTCCGGGAGCCGCTTGTGGGTCTTTCGGAAGA
TAACTGAAGTTCACAGTTACCAGCCAAGAAAACTTGAAAATGAGCAGCCGACGGAAACGTGCTCCTCCAGTGAGGGTAGATGAGGAAAAG
AGGCAGCAGCTTCATTGGAATATGCATGAGGACAGAAGGAATGAACCTATCATCATAAGTGATGATGACGAGCAGCCCTGCCCAGGTTCA
GATACCTCTTCTGCTCATTATATCATTCTAAGTGATAGTCTAAAGGAAGAAGTGGCTCACAGAGATAAGAAGAGGTGTTCAAAAGTGGTG
AGCTTCTCAAAACCAATTGAAAAAGAAGAGACTGTTGGTATTTTTTCCCCTTTGTCTGTAAAGTTAAATATTGTGATTTCTCCCTATCAT
TTTGATAATTCCTGGAAAGCATTTCTAGGAGAATTAACTCTTCAGCTTCTTCCTGCACAGAGTTTAATTGAAAATTTTTCCGAAAGGAGT
ATTACATTGATGAGTTCAGAGTCAAGCAATCAGTTCCTGATTTATGTTCATTCAAAAGGTGAAGATGTAGAGAAACAAAAAAAAGAACCG
ATGAGTATTTGTGACAAGGGTATTCTGGTGGAGTCATCCTTCAGTGGTGAAATGTTAGAAGATTTGGGGTGGCTACAAAAGAAGAGAAGA
ATAAAACTCTATCAGAAACCAGAAGGAAATCACATTATCAAGGTTGGAATTTATCTTTTGGAAGCTGGCCTAGCAAAACTAGACTTCTTG
AGTGATGCAAATTCAAGAATGAAAAAGTTCAATCAGCTCATGAAGAAAGTAATGGAAAAGTTACACAATTCTATTATTCCAGGATAGAAT
TTTTGCGGCATTTGAAGAGCTTTTTCCAGATTATGTTTAAAATTGAAACCAAGCCATGTGGTGAAGAACTCAAGGGTGGGGATAAAGTGC
TGATGACCTGTGTTGGCATTGGTTTCTCCAACCTTAGCAAGACCCTCAAGTGATAACCATCACAAGATAAGGCCCCAATGCCTACAGACA
AAGCAGAAGCTGCCACGGACACCAATGGGACCAAGTCCAAATGGATTAATCCAGGACAGAATAGCCACTTGCTTAATTTTCTGTGAAGAA

>81748_81748_6_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000367503_RCL1_chr9_4860125_ENST00000448872_length(amino acids)=267AA_BP=
MKFTVTSQENLKMSSRRKRAPPVRVDEEKRQQLHWNMHEDRRNEPIIISDDDEQPCPGSDTSSAHYIILSDSLKEEVAHRDKKRCSKVVS
FSKPIEKEETVGIFSPLSVKLNIVISPYHFDNSWKAFLGELTLQLLPAQSLIENFSERSITLMSSESSNQFLIYVHSKGEDVEKQKKEPM

--------------------------------------------------------------
>81748_81748_7_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000367505_RCL1_chr9_4860125_ENST00000381728_length(transcript)=1196nt_BP=1028nt
GTGCTCTGACGAGCGCGTTCGCCTTGACCCCACGCTACAGCGCGCGCCCGGCAGCTAGGCGCTGTGGTTTCTGGGTCTCCCGGGGGACCC
CTACACGTTCCGGCAAAAAGCGCTCGTGCCCACCTCAAGCCCATGTTCGGTGGGTGGCGAATGCGTGCCCGTGATCTGCTGGGTCTGTAG
AGGAGCGCAGGCCTGGTGCAAACAGACTCAAGAGGCTCGGAGAACCAGCTTGGAGTTCACAGTTACCAGCCAAGAAAACTTGAAAATGAG
CAGCCGACGGAAACGTGCTCCTCCAGTGAGGGTAGATGAGGAAAAGAGGCAGCAGCTTCATTGGAATATGCATGAGGACAGAAGGAATGA
ACCTATCATCATAAGTGATGATGACGAGCAGCCCTGCCCAGGTTCAGATACCTCTTCTGCTCATTATATCATTCTAAGTGATAGTCTAAA
GGAAGAAGTGGCTCACAGAGATAAGAAGAGGTGTTCAAAAGTGGTGAGCTTCTCAAAACCAATTGAAAAAGAAGAGACTGTTGGTATTTT
TTCCCCTTTGTCTGTAAAGTTAAATATTGTGATTTCTCCCTATCATTTTGATAATTCCTGGAAAGCATTTCTAGGAGAATTAACTCTTCA
GCTTCTTCCTGCACAGAGTTTAATTGAAAATTTTTCCGAAAGGAGTATTACATTGATGAGTTCAGAGTCAAGCAATCAGTTCCTGATTTA
TGTTCATTCAAAAGGTGAAGATGTAGAGAAACAAAAAAAAGAACCGATGAGTATTTGTGACAAGGGTATTCTGGTGGAGTCATCCTTCAG
TGGTGAAATGTTAGAAGATTTGGGGTGGCTACAAAAGAAGAGAAGAATAAAACTCTATCAGAAACCAGAAGGAAATCACATTATCAAGGT
TGGAATTTATCTTTTGGAAGCTGGCCTAGCAAAACTAGACTTCTTGAGTGATGCAAATTCAAGAATGAAAAAGTTCAATCAGCTCATGAA
GAAAGTAATGGAAAAGTTACACAATTCTATTATTCCAGGATAGAATTTTTGCGGCATTTGAAGAGCTTTTTCCAGATTATGTTTAAAATT
GAAACCAAGCCATGTGGTGAAGAACTCAAGGGTGGGGATAAAGTGCTGATGACCTGTGTTGGCATTGGTTTCTCCAACCTTAGCAAGACC

>81748_81748_7_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000367505_RCL1_chr9_4860125_ENST00000381728_length(amino acids)=323AA_BP=
MWFLGLPGDPYTFRQKALVPTSSPCSVGGECVPVICWVCRGAQAWCKQTQEARRTSLEFTVTSQENLKMSSRRKRAPPVRVDEEKRQQLH
WNMHEDRRNEPIIISDDDEQPCPGSDTSSAHYIILSDSLKEEVAHRDKKRCSKVVSFSKPIEKEETVGIFSPLSVKLNIVISPYHFDNSW
KAFLGELTLQLLPAQSLIENFSERSITLMSSESSNQFLIYVHSKGEDVEKQKKEPMSICDKGILVESSFSGEMLEDLGWLQKKRRIKLYQ

--------------------------------------------------------------
>81748_81748_8_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000367505_RCL1_chr9_4860125_ENST00000381730_length(transcript)=1376nt_BP=1028nt
GTGCTCTGACGAGCGCGTTCGCCTTGACCCCACGCTACAGCGCGCGCCCGGCAGCTAGGCGCTGTGGTTTCTGGGTCTCCCGGGGGACCC
CTACACGTTCCGGCAAAAAGCGCTCGTGCCCACCTCAAGCCCATGTTCGGTGGGTGGCGAATGCGTGCCCGTGATCTGCTGGGTCTGTAG
AGGAGCGCAGGCCTGGTGCAAACAGACTCAAGAGGCTCGGAGAACCAGCTTGGAGTTCACAGTTACCAGCCAAGAAAACTTGAAAATGAG
CAGCCGACGGAAACGTGCTCCTCCAGTGAGGGTAGATGAGGAAAAGAGGCAGCAGCTTCATTGGAATATGCATGAGGACAGAAGGAATGA
ACCTATCATCATAAGTGATGATGACGAGCAGCCCTGCCCAGGTTCAGATACCTCTTCTGCTCATTATATCATTCTAAGTGATAGTCTAAA
GGAAGAAGTGGCTCACAGAGATAAGAAGAGGTGTTCAAAAGTGGTGAGCTTCTCAAAACCAATTGAAAAAGAAGAGACTGTTGGTATTTT
TTCCCCTTTGTCTGTAAAGTTAAATATTGTGATTTCTCCCTATCATTTTGATAATTCCTGGAAAGCATTTCTAGGAGAATTAACTCTTCA
GCTTCTTCCTGCACAGAGTTTAATTGAAAATTTTTCCGAAAGGAGTATTACATTGATGAGTTCAGAGTCAAGCAATCAGTTCCTGATTTA
TGTTCATTCAAAAGGTGAAGATGTAGAGAAACAAAAAAAAGAACCGATGAGTATTTGTGACAAGGGTATTCTGGTGGAGTCATCCTTCAG
TGGTGAAATGTTAGAAGATTTGGGGTGGCTACAAAAGAAGAGAAGAATAAAACTCTATCAGAAACCAGAAGGAAATCACATTATCAAGGT
TGGAATTTATCTTTTGGAAGCTGGCCTAGCAAAACTAGACTTCTTGAGTGATGCAAATTCAAGAATGAAAAAGTTCAATCAGCTCATGAA
GAAAGTAATGGAAAAGTTACACAATTCTATTATTCCAGGATAGAATTTTTGCGGCATTTGAAGAGCTTTTTCCAGATTATGTTTAAAATT
GAAACCAAGCCATGTGGTGAAGAACTCAAGGGTGGGGATAAAGTGCTGATGACCTGTGTTGGCATTGGTTTCTCCAACCTTAGCAAGACC
CTCAAGTGATAACCATCACAAGATAAGGCCCCAATGCCTACAGACAAAGCAGAAGCTGCCACGGACACCAATGGGACCAAGTCCAAATGG
ATTAATCCAGGACAGAATAGCCACTTGCTTAATTTTCTGTGAAGAAATATCAATATACAAATAAAAGACATCCCTGTAGCATATGGTTTC

>81748_81748_8_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000367505_RCL1_chr9_4860125_ENST00000381730_length(amino acids)=323AA_BP=
MWFLGLPGDPYTFRQKALVPTSSPCSVGGECVPVICWVCRGAQAWCKQTQEARRTSLEFTVTSQENLKMSSRRKRAPPVRVDEEKRQQLH
WNMHEDRRNEPIIISDDDEQPCPGSDTSSAHYIILSDSLKEEVAHRDKKRCSKVVSFSKPIEKEETVGIFSPLSVKLNIVISPYHFDNSW
KAFLGELTLQLLPAQSLIENFSERSITLMSSESSNQFLIYVHSKGEDVEKQKKEPMSICDKGILVESSFSGEMLEDLGWLQKKRRIKLYQ

--------------------------------------------------------------
>81748_81748_9_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000367505_RCL1_chr9_4860125_ENST00000448872_length(transcript)=1340nt_BP=1028nt
GTGCTCTGACGAGCGCGTTCGCCTTGACCCCACGCTACAGCGCGCGCCCGGCAGCTAGGCGCTGTGGTTTCTGGGTCTCCCGGGGGACCC
CTACACGTTCCGGCAAAAAGCGCTCGTGCCCACCTCAAGCCCATGTTCGGTGGGTGGCGAATGCGTGCCCGTGATCTGCTGGGTCTGTAG
AGGAGCGCAGGCCTGGTGCAAACAGACTCAAGAGGCTCGGAGAACCAGCTTGGAGTTCACAGTTACCAGCCAAGAAAACTTGAAAATGAG
CAGCCGACGGAAACGTGCTCCTCCAGTGAGGGTAGATGAGGAAAAGAGGCAGCAGCTTCATTGGAATATGCATGAGGACAGAAGGAATGA
ACCTATCATCATAAGTGATGATGACGAGCAGCCCTGCCCAGGTTCAGATACCTCTTCTGCTCATTATATCATTCTAAGTGATAGTCTAAA
GGAAGAAGTGGCTCACAGAGATAAGAAGAGGTGTTCAAAAGTGGTGAGCTTCTCAAAACCAATTGAAAAAGAAGAGACTGTTGGTATTTT
TTCCCCTTTGTCTGTAAAGTTAAATATTGTGATTTCTCCCTATCATTTTGATAATTCCTGGAAAGCATTTCTAGGAGAATTAACTCTTCA
GCTTCTTCCTGCACAGAGTTTAATTGAAAATTTTTCCGAAAGGAGTATTACATTGATGAGTTCAGAGTCAAGCAATCAGTTCCTGATTTA
TGTTCATTCAAAAGGTGAAGATGTAGAGAAACAAAAAAAAGAACCGATGAGTATTTGTGACAAGGGTATTCTGGTGGAGTCATCCTTCAG
TGGTGAAATGTTAGAAGATTTGGGGTGGCTACAAAAGAAGAGAAGAATAAAACTCTATCAGAAACCAGAAGGAAATCACATTATCAAGGT
TGGAATTTATCTTTTGGAAGCTGGCCTAGCAAAACTAGACTTCTTGAGTGATGCAAATTCAAGAATGAAAAAGTTCAATCAGCTCATGAA
GAAAGTAATGGAAAAGTTACACAATTCTATTATTCCAGGATAGAATTTTTGCGGCATTTGAAGAGCTTTTTCCAGATTATGTTTAAAATT
GAAACCAAGCCATGTGGTGAAGAACTCAAGGGTGGGGATAAAGTGCTGATGACCTGTGTTGGCATTGGTTTCTCCAACCTTAGCAAGACC
CTCAAGTGATAACCATCACAAGATAAGGCCCCAATGCCTACAGACAAAGCAGAAGCTGCCACGGACACCAATGGGACCAAGTCCAAATGG

>81748_81748_9_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000367505_RCL1_chr9_4860125_ENST00000448872_length(amino acids)=323AA_BP=
MWFLGLPGDPYTFRQKALVPTSSPCSVGGECVPVICWVCRGAQAWCKQTQEARRTSLEFTVTSQENLKMSSRRKRAPPVRVDEEKRQQLH
WNMHEDRRNEPIIISDDDEQPCPGSDTSSAHYIILSDSLKEEVAHRDKKRCSKVVSFSKPIEKEETVGIFSPLSVKLNIVISPYHFDNSW
KAFLGELTLQLLPAQSLIENFSERSITLMSSESSNQFLIYVHSKGEDVEKQKKEPMSICDKGILVESSFSGEMLEDLGWLQKKRRIKLYQ

--------------------------------------------------------------
>81748_81748_10_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000438092_RCL1_chr9_4860125_ENST00000381728_length(transcript)=1330nt_BP=1162nt
GTCTTTGGCCTCCGGGACCAGGGAGGGAGGACGCTGGTTGTCCTGGAGCCCGGGAAGCTCAAGGGCTGAGAGGGAGCCGCTGCGCGAGTC
TTCCCCACCTCTTCCCGATCCCGGACTAGCGAACTTCGGACCACCACGTCCCTCCGGGGATAAAGTGGGGTCGTGGGAAAGGAGGCTGTG
CTTCTCCTCATGCACTGGGGCCTGCGGTGTTTGTCTCGAGCGTCCAACACACTAGGATCCGGGAGTCCGTCGTCACGCTCCTTGGCCTCG
CGGTCGCTTGTTTGCTCGGCCTGCTGGGAGCGATCCGGCGCTGACAGCCCCGCTCAGACTCCGGGAGCCGCTTGTGGGTCTTTCGGAAGA
TAACTGAAGTTCACAGTTACCAGCCAAGAAAACTTGAAAATGAGCAGCCGACGGAAACGTGCTCCTCCAGTGAGGGTAGATGAGGAAAAG
AGGCAGCAGCTTCATTGGAATATGCATGAGGACAGAAGGAATGAACCTATCATCATAAGTGATGATGACGAGCAGCCCTGCCCAGGTTCA
GATACCTCTTCTGCTCATTATATCATTCTAAGTGATAGTCTAAAGGAAGAAGTGGCTCACAGAGATAAGAAGAGGTGTTCAAAAGTGGTG
AGCTTCTCAAAACCAATTGAAAAAGAAGAGACTGTTGGTATTTTTTCCCCTTTGTCTGTAAAGTTAAATATTGTGATTTCTCCCTATCAT
TTTGATAATTCCTGGAAAGCATTTCTAGGAGAATTAACTCTTCAGCTTCTTCCTGCACAGAGTTTAATTGAAAATTTTTCCGAAAGGAGT
ATTACATTGATGAGTTCAGAGTCAAGCAATCAGTTCCTGATTTATGTTCATTCAAAAGGTGAAGATGTAGAGAAACAAAAAAAAGAACCG
ATGAGTATTTGTGACAAGGGTATTCTGGTGGAGTCATCCTTCAGTGGTGAAATGTTAGAAGATTTGGGGTGGCTACAAAAGAAGAGAAGA
ATAAAACTCTATCAGAAACCAGAAGGAAATCACATTATCAAGGTTGGAATTTATCTTTTGGAAGCTGGCCTAGCAAAACTAGACTTCTTG
AGTGATGCAAATTCAAGAATGAAAAAGTTCAATCAGCTCATGAAGAAAGTAATGGAAAAGTTACACAATTCTATTATTCCAGGATAGAAT
TTTTGCGGCATTTGAAGAGCTTTTTCCAGATTATGTTTAAAATTGAAACCAAGCCATGTGGTGAAGAACTCAAGGGTGGGGATAAAGTGC

>81748_81748_10_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000438092_RCL1_chr9_4860125_ENST00000381728_length(amino acids)=267AA_BP=
MKFTVTSQENLKMSSRRKRAPPVRVDEEKRQQLHWNMHEDRRNEPIIISDDDEQPCPGSDTSSAHYIILSDSLKEEVAHRDKKRCSKVVS
FSKPIEKEETVGIFSPLSVKLNIVISPYHFDNSWKAFLGELTLQLLPAQSLIENFSERSITLMSSESSNQFLIYVHSKGEDVEKQKKEPM

--------------------------------------------------------------
>81748_81748_11_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000438092_RCL1_chr9_4860125_ENST00000381730_length(transcript)=1510nt_BP=1162nt
GTCTTTGGCCTCCGGGACCAGGGAGGGAGGACGCTGGTTGTCCTGGAGCCCGGGAAGCTCAAGGGCTGAGAGGGAGCCGCTGCGCGAGTC
TTCCCCACCTCTTCCCGATCCCGGACTAGCGAACTTCGGACCACCACGTCCCTCCGGGGATAAAGTGGGGTCGTGGGAAAGGAGGCTGTG
CTTCTCCTCATGCACTGGGGCCTGCGGTGTTTGTCTCGAGCGTCCAACACACTAGGATCCGGGAGTCCGTCGTCACGCTCCTTGGCCTCG
CGGTCGCTTGTTTGCTCGGCCTGCTGGGAGCGATCCGGCGCTGACAGCCCCGCTCAGACTCCGGGAGCCGCTTGTGGGTCTTTCGGAAGA
TAACTGAAGTTCACAGTTACCAGCCAAGAAAACTTGAAAATGAGCAGCCGACGGAAACGTGCTCCTCCAGTGAGGGTAGATGAGGAAAAG
AGGCAGCAGCTTCATTGGAATATGCATGAGGACAGAAGGAATGAACCTATCATCATAAGTGATGATGACGAGCAGCCCTGCCCAGGTTCA
GATACCTCTTCTGCTCATTATATCATTCTAAGTGATAGTCTAAAGGAAGAAGTGGCTCACAGAGATAAGAAGAGGTGTTCAAAAGTGGTG
AGCTTCTCAAAACCAATTGAAAAAGAAGAGACTGTTGGTATTTTTTCCCCTTTGTCTGTAAAGTTAAATATTGTGATTTCTCCCTATCAT
TTTGATAATTCCTGGAAAGCATTTCTAGGAGAATTAACTCTTCAGCTTCTTCCTGCACAGAGTTTAATTGAAAATTTTTCCGAAAGGAGT
ATTACATTGATGAGTTCAGAGTCAAGCAATCAGTTCCTGATTTATGTTCATTCAAAAGGTGAAGATGTAGAGAAACAAAAAAAAGAACCG
ATGAGTATTTGTGACAAGGGTATTCTGGTGGAGTCATCCTTCAGTGGTGAAATGTTAGAAGATTTGGGGTGGCTACAAAAGAAGAGAAGA
ATAAAACTCTATCAGAAACCAGAAGGAAATCACATTATCAAGGTTGGAATTTATCTTTTGGAAGCTGGCCTAGCAAAACTAGACTTCTTG
AGTGATGCAAATTCAAGAATGAAAAAGTTCAATCAGCTCATGAAGAAAGTAATGGAAAAGTTACACAATTCTATTATTCCAGGATAGAAT
TTTTGCGGCATTTGAAGAGCTTTTTCCAGATTATGTTTAAAATTGAAACCAAGCCATGTGGTGAAGAACTCAAGGGTGGGGATAAAGTGC
TGATGACCTGTGTTGGCATTGGTTTCTCCAACCTTAGCAAGACCCTCAAGTGATAACCATCACAAGATAAGGCCCCAATGCCTACAGACA
AAGCAGAAGCTGCCACGGACACCAATGGGACCAAGTCCAAATGGATTAATCCAGGACAGAATAGCCACTTGCTTAATTTTCTGTGAAGAA

>81748_81748_11_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000438092_RCL1_chr9_4860125_ENST00000381730_length(amino acids)=267AA_BP=
MKFTVTSQENLKMSSRRKRAPPVRVDEEKRQQLHWNMHEDRRNEPIIISDDDEQPCPGSDTSSAHYIILSDSLKEEVAHRDKKRCSKVVS
FSKPIEKEETVGIFSPLSVKLNIVISPYHFDNSWKAFLGELTLQLLPAQSLIENFSERSITLMSSESSNQFLIYVHSKGEDVEKQKKEPM

--------------------------------------------------------------
>81748_81748_12_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000438092_RCL1_chr9_4860125_ENST00000448872_length(transcript)=1474nt_BP=1162nt
GTCTTTGGCCTCCGGGACCAGGGAGGGAGGACGCTGGTTGTCCTGGAGCCCGGGAAGCTCAAGGGCTGAGAGGGAGCCGCTGCGCGAGTC
TTCCCCACCTCTTCCCGATCCCGGACTAGCGAACTTCGGACCACCACGTCCCTCCGGGGATAAAGTGGGGTCGTGGGAAAGGAGGCTGTG
CTTCTCCTCATGCACTGGGGCCTGCGGTGTTTGTCTCGAGCGTCCAACACACTAGGATCCGGGAGTCCGTCGTCACGCTCCTTGGCCTCG
CGGTCGCTTGTTTGCTCGGCCTGCTGGGAGCGATCCGGCGCTGACAGCCCCGCTCAGACTCCGGGAGCCGCTTGTGGGTCTTTCGGAAGA
TAACTGAAGTTCACAGTTACCAGCCAAGAAAACTTGAAAATGAGCAGCCGACGGAAACGTGCTCCTCCAGTGAGGGTAGATGAGGAAAAG
AGGCAGCAGCTTCATTGGAATATGCATGAGGACAGAAGGAATGAACCTATCATCATAAGTGATGATGACGAGCAGCCCTGCCCAGGTTCA
GATACCTCTTCTGCTCATTATATCATTCTAAGTGATAGTCTAAAGGAAGAAGTGGCTCACAGAGATAAGAAGAGGTGTTCAAAAGTGGTG
AGCTTCTCAAAACCAATTGAAAAAGAAGAGACTGTTGGTATTTTTTCCCCTTTGTCTGTAAAGTTAAATATTGTGATTTCTCCCTATCAT
TTTGATAATTCCTGGAAAGCATTTCTAGGAGAATTAACTCTTCAGCTTCTTCCTGCACAGAGTTTAATTGAAAATTTTTCCGAAAGGAGT
ATTACATTGATGAGTTCAGAGTCAAGCAATCAGTTCCTGATTTATGTTCATTCAAAAGGTGAAGATGTAGAGAAACAAAAAAAAGAACCG
ATGAGTATTTGTGACAAGGGTATTCTGGTGGAGTCATCCTTCAGTGGTGAAATGTTAGAAGATTTGGGGTGGCTACAAAAGAAGAGAAGA
ATAAAACTCTATCAGAAACCAGAAGGAAATCACATTATCAAGGTTGGAATTTATCTTTTGGAAGCTGGCCTAGCAAAACTAGACTTCTTG
AGTGATGCAAATTCAAGAATGAAAAAGTTCAATCAGCTCATGAAGAAAGTAATGGAAAAGTTACACAATTCTATTATTCCAGGATAGAAT
TTTTGCGGCATTTGAAGAGCTTTTTCCAGATTATGTTTAAAATTGAAACCAAGCCATGTGGTGAAGAACTCAAGGGTGGGGATAAAGTGC
TGATGACCTGTGTTGGCATTGGTTTCTCCAACCTTAGCAAGACCCTCAAGTGATAACCATCACAAGATAAGGCCCCAATGCCTACAGACA
AAGCAGAAGCTGCCACGGACACCAATGGGACCAAGTCCAAATGGATTAATCCAGGACAGAATAGCCACTTGCTTAATTTTCTGTGAAGAA

>81748_81748_12_SHPRH-RCL1_SHPRH_chr6_146273485_ENST00000438092_RCL1_chr9_4860125_ENST00000448872_length(amino acids)=267AA_BP=
MKFTVTSQENLKMSSRRKRAPPVRVDEEKRQQLHWNMHEDRRNEPIIISDDDEQPCPGSDTSSAHYIILSDSLKEEVAHRDKKRCSKVVS
FSKPIEKEETVGIFSPLSVKLNIVISPYHFDNSWKAFLGELTLQLLPAQSLIENFSERSITLMSSESSNQFLIYVHSKGEDVEKQKKEPM

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Fusion Gene PPI Analysis for SHPRH-RCL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SHPRH-RCL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SHPRH-RCL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource