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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATP6V1E1-BID (FusionGDB2 ID:8175)

Fusion Gene Summary for ATP6V1E1-BID

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP6V1E1-BID
Fusion gene ID: 8175
HgeneTgene
Gene symbol

ATP6V1E1

BID

Gene ID

529

637

Gene nameATPase H+ transporting V1 subunit E1BH3 interacting domain death agonist
SynonymsARCL2C|ATP6E|ATP6E2|ATP6V1E|P31|Vma4FP497
Cytomap

22q11.21

22q11.21

Type of geneprotein-codingprotein-coding
DescriptionV-type proton ATPase subunit E 1ATPase, H+ transporting, lysosomal 31kDa, V1 subunit E1H(+)-transporting two-sector ATPase, 31kDa subunitH+-transporting ATP synthase chain E, vacuolarV-ATPase 31 kDa subunitV-ATPase subunit E 1V-ATPase, subunit EvacBH3-interacting domain death agonistBH3 interacting domain death agonist Si6 isoformBID isoform ES(1b)BID isoform L(2)BID isoform Si6Human BID coding sequenceapoptic death agonistdesmocollin type 4p22 BID
Modification date2020031320200313
UniProtAcc

P36543

P55957

Ensembl transtripts involved in fusion geneENST00000253413, ENST00000399796, 
ENST00000399798, ENST00000478963, 
ENST00000399767, ENST00000399774, 
ENST00000473439, ENST00000342111, 
ENST00000399765, ENST00000551952, 
ENST00000317361, 
Fusion gene scores* DoF score7 X 7 X 2=988 X 6 X 7=336
# samples 79
** MAII scorelog2(7/98*10)=-0.485426827170242
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP6V1E1 [Title/Abstract] AND BID [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATP6V1E1(18095578)-BID(18226779), # samples:1
BID(18220783)-ATP6V1E1(18096086), # samples:1
BID(18220782)-ATP6V1E1(18096086), # samples:1
Anticipated loss of major functional domain due to fusion event.BID-ATP6V1E1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
BID-ATP6V1E1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
BID-ATP6V1E1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBID

GO:0001836

release of cytochrome c from mitochondria

17052454

TgeneBID

GO:0031334

positive regulation of protein complex assembly

19074440|21041309

TgeneBID

GO:0090150

establishment of protein localization to membrane

21041309


check buttonFusion gene breakpoints across ATP6V1E1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BID (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-05-4389-01AATP6V1E1chr22

18095578

-BIDchr22

18226779

-


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Fusion Gene ORF analysis for ATP6V1E1-BID

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000253413ENST00000399767ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-5UTRENST00000253413ENST00000399774ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-5UTRENST00000253413ENST00000473439ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-5UTRENST00000399796ENST00000399767ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-5UTRENST00000399796ENST00000399774ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-5UTRENST00000399796ENST00000473439ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-5UTRENST00000399798ENST00000399767ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-5UTRENST00000399798ENST00000399774ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-5UTRENST00000399798ENST00000473439ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-intronENST00000253413ENST00000342111ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-intronENST00000253413ENST00000399765ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-intronENST00000253413ENST00000551952ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-intronENST00000399796ENST00000342111ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-intronENST00000399796ENST00000399765ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-intronENST00000399796ENST00000551952ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-intronENST00000399798ENST00000342111ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-intronENST00000399798ENST00000399765ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
5CDS-intronENST00000399798ENST00000551952ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
In-frameENST00000253413ENST00000317361ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
In-frameENST00000399796ENST00000317361ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
In-frameENST00000399798ENST00000317361ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
intron-3CDSENST00000478963ENST00000317361ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
intron-5UTRENST00000478963ENST00000399767ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
intron-5UTRENST00000478963ENST00000399774ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
intron-5UTRENST00000478963ENST00000473439ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
intron-intronENST00000478963ENST00000342111ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
intron-intronENST00000478963ENST00000399765ATP6V1E1chr22

18095578

-BIDchr22

18226779

-
intron-intronENST00000478963ENST00000551952ATP6V1E1chr22

18095578

-BIDchr22

18226779

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000253413ATP6V1E1chr2218095578-ENST00000317361BIDchr2218226779-24754591081034308
ENST00000399796ATP6V1E1chr2218095578-ENST00000317361BIDchr2218226779-240438837963308
ENST00000399798ATP6V1E1chr2218095578-ENST00000317361BIDchr2218226779-234032439899286

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000253413ENST00000317361ATP6V1E1chr2218095578-BIDchr2218226779-0.0018557960.99814427
ENST00000399796ENST00000317361ATP6V1E1chr2218095578-BIDchr2218226779-0.0018455340.99815446
ENST00000399798ENST00000317361ATP6V1E1chr2218095578-BIDchr2218226779-0.0013033330.99869674

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Fusion Genomic Features for ATP6V1E1-BID


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for ATP6V1E1-BID


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:18095578/chr22:18226779)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP6V1E1

P36543

BID

P55957

FUNCTION: Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.FUNCTION: The major proteolytic product p15 BID allows the release of cytochrome c (By similarity). Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. {ECO:0000250|UniProtKB:P70444, ECO:0000269|PubMed:14583606}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBIDchr22:18095578chr22:18226779ENST000003173611686_10050242.0MotifBH3
TgeneBIDchr22:18095578chr22:18226779ENST000003421111786_1004182.33333333333334MotifBH3
TgeneBIDchr22:18095578chr22:18226779ENST000003997650486_1000100.0MotifBH3
TgeneBIDchr22:18095578chr22:18226779ENST000003997670586_1000100.0MotifBH3
TgeneBIDchr22:18095578chr22:18226779ENST000003997741686_1004196.0MotifBH3
TgeneBIDchr22:18095578chr22:18226779ENST000005519521686_1004196.0MotifBH3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for ATP6V1E1-BID


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8175_8175_1_ATP6V1E1-BID_ATP6V1E1_chr22_18095578_ENST00000253413_BID_chr22_18226779_ENST00000317361_length(transcript)=2475nt_BP=459nt
TCCCATTGGCTGAGAAGGGTCATGAGGATGAACTGTGCAGTCACCTGGCAGGAACCGGAACCCGCGGTTATAAAGTAAAGGAACCCGAGA
TCTGCGCAGGGGTTCCCTTTGCCGATTTCTCTCACCTCACCTTTCAAACCTAAACTCGAGCCTACTGTTCACCGGCCTAGCATTGCTCTC
GCCATGGCTCTCAGCGATGCTGACGTGCAAAAGCAGATAAAGCATATGATGGCTTTCATTGAACAAGAAGCCAATGAGAAAGCAGAAGAA
ATAGATGCAAAGGCAGAAGAAGAGTTCAACATAGAGAAAGGTCGGCTTGTGCAAACCCAAAGACTAAAGATTATGGAATATTATGAGAAG
AAAGAGAAACAGATTGAGCAGCAGAAGAAAATTCAGATGTCCAATTTGATGAATCAAGCGAGACTCAAAGTCCTCAGAGCAAGAGATGAC
CTTATCACAGTCAACAACGGTTCCAGCCTCAGGGATGAGTGCATCACAAACCTACTGGTGTTTGGCTTCCTCCAAAGCTGTTCTGACAAC
AGCTTCCGCAGAGAGCTGGACGCACTGGGCCACGAGCTGCCAGTGCTGGCTCCCCAGTGGGAGGGCTACGATGAGCTGCAGACTGATGGC
AACCGCAGCAGCCACTCCCGCTTGGGAAGAATAGAGGCAGATTCTGAAAGTCAAGAAGACATCATCCGGAATATTGCCAGGCACCTCGCC
CAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTGAACGGCCTGGCCCTGCAGCTCAGGAACACCAGCCGGTCGGAGGAG
GACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGGAGAAGGAGAAGACCATGCTGGTGCTG
GCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACAACAGTGAATTTTATTAACCAGAAC
CTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGATGTGGTCA
CAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTGTGACTTCT
ATTTTAAAGACAATGTTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTCCATTTACACGTATTTGAAT
GGCCTTCATATCATCCACACATGAATCTGCACATCTGTAAATCTACACACGGTGCCTTTATTTCCACTGTGCAGGTTCCCACTTAAAAAT
TAAATTGGAAAGCAGGTTTCAAGGAAGTAGAAACAAAATACAATTTTTTTGGTAAAAAAAAATTACTGTTTATTAAAGTACAACCATAGA
GGATGGTCTTACAGCAGGCAGTATCCTGTTTGAGGAAAGCAAGAATCAGAGAAGGAACATACCCCTTACAAATGAAAAATTCCACTCAAA
ATAGGGACTATCTATCTTAATACTAAGGAACCAACAATCTTCCTGTTTAAAAAACCACATGGCACAGAGATTCTGAACTAAAGTGCTGCA
CTCAAATGATGGGAAGTCCGGCCCCAGTACACAGGGGCTTGACTTTTTCAACTTCGTTTCCTTTGTTGGAGTCAAAAAGAACCACTTGTG
GTTCTAAAAGGTGTGAAGGTGATTTAAGGGCCCAGGTCAGCCACTGTTTGTTTACAAAATCAGGTAACTAACTGCATACACTTTTTCTCT
TTCCATGACATCAAGACTTTGCTAAAGACATGAAGCCACGGGTGCCAGAAGCTACTGCGATGCCCCGGGAGTTAGCCCCCTGGTAATAGC
TGTAAACTTCCAATTTCTAGCCATACGCTCAGCTCATCCATGCCTCAGAAGTGCATCTGGAGAGAACAGGTTTCTAAGCATAAAAGATGA
AAGAGCAGTTGGACTTTTTAAAAATTCAGCAAAGTGGTTCCCTCTCTTAGGGACAGTCAAAACCAAGTCACTTAGGTAGTACCAAAATAA
ATAAGGAAAAGCTTAGCTTTAGAAACAGTGCAACACTGGTCTGCTGTTCCAGTGGTAAGCTATGTCCCAGGAATCAGTTTAAAAGCACGA
CAGTGGATGCTGGGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACAACATGAGGCCACTGGAGACGCATATGAGTA
AGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCAGAAAGGAAAAACAAACTCTA
TATTGTTCAGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAAGTGCTGCCGC

>8175_8175_1_ATP6V1E1-BID_ATP6V1E1_chr22_18095578_ENST00000253413_BID_chr22_18226779_ENST00000317361_length(amino acids)=308AA_BP=117
MPISLTSPFKPKLEPTVHRPSIALAMALSDADVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIE
QQKKIQMSNLMNQARLKVLRARDDLITVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHS
RLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAK

--------------------------------------------------------------
>8175_8175_2_ATP6V1E1-BID_ATP6V1E1_chr22_18095578_ENST00000399796_BID_chr22_18226779_ENST00000317361_length(transcript)=2404nt_BP=388nt
AAAGTAAAGGAACCCGAGATCTGCGCAGGGGTTCCCTTTGCCGATTTCTCTCACCTCACCTTTCAAACCTAAACTCGAGCCTACTGTTCA
CCGGCCTAGCATTGCTCTCGCCATGGCTCTCAGCGATGCTGACGTGCAAAAGCAGATAAAGCATATGATGGCTTTCATTGAACAAGAAGC
CAATGAGAAAGCAGAAGAAATAGATGCAAAGGCAGAAGAAGAGTTCAACATAGAGAAAGGTCGGCTTGTGCAAACCCAAAGACTAAAGAT
TATGGAATATTATGAGAAGAAAGAGAAACAGATTGAGCAGCAGAAGAAAATTCAGATGTCCAATTTGATGAATCAAGCGAGACTCAAAGT
CCTCAGAGCAAGAGATGACCTTATCACAGTCAACAACGGTTCCAGCCTCAGGGATGAGTGCATCACAAACCTACTGGTGTTTGGCTTCCT
CCAAAGCTGTTCTGACAACAGCTTCCGCAGAGAGCTGGACGCACTGGGCCACGAGCTGCCAGTGCTGGCTCCCCAGTGGGAGGGCTACGA
TGAGCTGCAGACTGATGGCAACCGCAGCAGCCACTCCCGCTTGGGAAGAATAGAGGCAGATTCTGAAAGTCAAGAAGACATCATCCGGAA
TATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTGAACGGCCTGGCCCTGCAGCTCAGGAA
CACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAGGCCTACCCTAGAGACATGGAGAAGGA
GAAGACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTGCTCCGTGATGTCTTTCACACAACAGT
GAATTTTATTAACCAGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGAACGGACAGTTCCAGAAGTGTGACTGG
CTAAAGCTCGATGTGGTCACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCAACAGCGTTCCTAGAGAAGACAGGCTG
GAAGATAGCTGTGACTTCTATTTTAAAGACAATGTTAAACTTATAACCCACTTTAAAATATCTACATTAATATACTTGAATGAAAATGTC
CATTTACACGTATTTGAATGGCCTTCATATCATCCACACATGAATCTGCACATCTGTAAATCTACACACGGTGCCTTTATTTCCACTGTG
CAGGTTCCCACTTAAAAATTAAATTGGAAAGCAGGTTTCAAGGAAGTAGAAACAAAATACAATTTTTTTGGTAAAAAAAAATTACTGTTT
ATTAAAGTACAACCATAGAGGATGGTCTTACAGCAGGCAGTATCCTGTTTGAGGAAAGCAAGAATCAGAGAAGGAACATACCCCTTACAA
ATGAAAAATTCCACTCAAAATAGGGACTATCTATCTTAATACTAAGGAACCAACAATCTTCCTGTTTAAAAAACCACATGGCACAGAGAT
TCTGAACTAAAGTGCTGCACTCAAATGATGGGAAGTCCGGCCCCAGTACACAGGGGCTTGACTTTTTCAACTTCGTTTCCTTTGTTGGAG
TCAAAAAGAACCACTTGTGGTTCTAAAAGGTGTGAAGGTGATTTAAGGGCCCAGGTCAGCCACTGTTTGTTTACAAAATCAGGTAACTAA
CTGCATACACTTTTTCTCTTTCCATGACATCAAGACTTTGCTAAAGACATGAAGCCACGGGTGCCAGAAGCTACTGCGATGCCCCGGGAG
TTAGCCCCCTGGTAATAGCTGTAAACTTCCAATTTCTAGCCATACGCTCAGCTCATCCATGCCTCAGAAGTGCATCTGGAGAGAACAGGT
TTCTAAGCATAAAAGATGAAAGAGCAGTTGGACTTTTTAAAAATTCAGCAAAGTGGTTCCCTCTCTTAGGGACAGTCAAAACCAAGTCAC
TTAGGTAGTACCAAAATAAATAAGGAAAAGCTTAGCTTTAGAAACAGTGCAACACTGGTCTGCTGTTCCAGTGGTAAGCTATGTCCCAGG
AATCAGTTTAAAAGCACGACAGTGGATGCTGGGTCCATATCACACACATTGCTGTGAACAGGAAACTCCTGTGACCACAACATGAGGCCA
CTGGAGACGCATATGAGTAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCTGTTCTTTAAGAGTTTAAAATCATCAG
AAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGGCTGGCTCAATTGAAAGTGGGCAAAAGCTTACAAATAC

>8175_8175_2_ATP6V1E1-BID_ATP6V1E1_chr22_18095578_ENST00000399796_BID_chr22_18226779_ENST00000317361_length(amino acids)=308AA_BP=117
MPISLTSPFKPKLEPTVHRPSIALAMALSDADVQKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIE
QQKKIQMSNLMNQARLKVLRARDDLITVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHS
RLGRIEADSESQEDIIRNIARHLAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAK

--------------------------------------------------------------
>8175_8175_3_ATP6V1E1-BID_ATP6V1E1_chr22_18095578_ENST00000399798_BID_chr22_18226779_ENST00000317361_length(transcript)=2340nt_BP=324nt
ATAAAGTAAAGGAACCCGAGATCTGCGCAGGGGTTCCCTTTGCCGATTTCTCTCACCTCACCTTTCAAACCTAAACTCGAGCCTACTGTT
CACCGGCCTAGCATTGCTCTCGCCATGGCTCTCAGCGATGCTGACGTGCAAAAGCAGGCAGAAGAAGAGTTCAACATAGAGAAAGGTCGG
CTTGTGCAAACCCAAAGACTAAAGATTATGGAATATTATGAGAAGAAAGAGAAACAGATTGAGCAGCAGAAGAAAATTCAGATGTCCAAT
TTGATGAATCAAGCGAGACTCAAAGTCCTCAGAGCAAGAGATGACCTTATCACAGTCAACAACGGTTCCAGCCTCAGGGATGAGTGCATC
ACAAACCTACTGGTGTTTGGCTTCCTCCAAAGCTGTTCTGACAACAGCTTCCGCAGAGAGCTGGACGCACTGGGCCACGAGCTGCCAGTG
CTGGCTCCCCAGTGGGAGGGCTACGATGAGCTGCAGACTGATGGCAACCGCAGCAGCCACTCCCGCTTGGGAAGAATAGAGGCAGATTCT
GAAAGTCAAGAAGACATCATCCGGAATATTGCCAGGCACCTCGCCCAGGTCGGGGACAGCATGGACCGTAGCATCCCTCCGGGCCTGGTG
AACGGCCTGGCCCTGCAGCTCAGGAACACCAGCCGGTCGGAGGAGGACCGGAACAGGGACCTGGCCACTGCCCTGGAGCAGCTGCTGCAG
GCCTACCCTAGAGACATGGAGAAGGAGAAGACCATGCTGGTGCTGGCCCTGCTGCTGGCCAAGAAGGTGGCCAGTCACACGCCGTCCTTG
CTCCGTGATGTCTTTCACACAACAGTGAATTTTATTAACCAGAACCTACGCACCTACGTGAGGAGCTTAGCCAGAAATGGGATGGACTGA
ACGGACAGTTCCAGAAGTGTGACTGGCTAAAGCTCGATGTGGTCACAGCTGTATAGCTGCTTCCAGTGTAGACGGAGCCCTGGCATGTCA
ACAGCGTTCCTAGAGAAGACAGGCTGGAAGATAGCTGTGACTTCTATTTTAAAGACAATGTTAAACTTATAACCCACTTTAAAATATCTA
CATTAATATACTTGAATGAAAATGTCCATTTACACGTATTTGAATGGCCTTCATATCATCCACACATGAATCTGCACATCTGTAAATCTA
CACACGGTGCCTTTATTTCCACTGTGCAGGTTCCCACTTAAAAATTAAATTGGAAAGCAGGTTTCAAGGAAGTAGAAACAAAATACAATT
TTTTTGGTAAAAAAAAATTACTGTTTATTAAAGTACAACCATAGAGGATGGTCTTACAGCAGGCAGTATCCTGTTTGAGGAAAGCAAGAA
TCAGAGAAGGAACATACCCCTTACAAATGAAAAATTCCACTCAAAATAGGGACTATCTATCTTAATACTAAGGAACCAACAATCTTCCTG
TTTAAAAAACCACATGGCACAGAGATTCTGAACTAAAGTGCTGCACTCAAATGATGGGAAGTCCGGCCCCAGTACACAGGGGCTTGACTT
TTTCAACTTCGTTTCCTTTGTTGGAGTCAAAAAGAACCACTTGTGGTTCTAAAAGGTGTGAAGGTGATTTAAGGGCCCAGGTCAGCCACT
GTTTGTTTACAAAATCAGGTAACTAACTGCATACACTTTTTCTCTTTCCATGACATCAAGACTTTGCTAAAGACATGAAGCCACGGGTGC
CAGAAGCTACTGCGATGCCCCGGGAGTTAGCCCCCTGGTAATAGCTGTAAACTTCCAATTTCTAGCCATACGCTCAGCTCATCCATGCCT
CAGAAGTGCATCTGGAGAGAACAGGTTTCTAAGCATAAAAGATGAAAGAGCAGTTGGACTTTTTAAAAATTCAGCAAAGTGGTTCCCTCT
CTTAGGGACAGTCAAAACCAAGTCACTTAGGTAGTACCAAAATAAATAAGGAAAAGCTTAGCTTTAGAAACAGTGCAACACTGGTCTGCT
GTTCCAGTGGTAAGCTATGTCCCAGGAATCAGTTTAAAAGCACGACAGTGGATGCTGGGTCCATATCACACACATTGCTGTGAACAGGAA
ACTCCTGTGACCACAACATGAGGCCACTGGAGACGCATATGAGTAAGGGCACTGACGGACTCATGATTTCTTCTTACCAGATGCTTTCCT
GTTCTTTAAGAGTTTAAAATCATCAGAAAGGAAAAACAAACTCTATATTGTTCAGCATGCAATACATACCACGCTAGGGCTGGCTCAATT
GAAAGTGGGCAAAAGCTTACAAATACTAAAAAGAAGTGCTGCCGCGCAGTGTGGAGGCCACTGTTTGGAAATAAATCTTCCTAACACTAC

>8175_8175_3_ATP6V1E1-BID_ATP6V1E1_chr22_18095578_ENST00000399798_BID_chr22_18226779_ENST00000317361_length(amino acids)=286AA_BP=95
MPISLTSPFKPKLEPTVHRPSIALAMALSDADVQKQAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKIQMSNLMNQARLKVLRAR
DDLITVNNGSSLRDECITNLLVFGFLQSCSDNSFRRELDALGHELPVLAPQWEGYDELQTDGNRSSHSRLGRIEADSESQEDIIRNIARH
LAQVGDSMDRSIPPGLVNGLALQLRNTSRSEEDRNRDLATALEQLLQAYPRDMEKEKTMLVLALLLAKKVASHTPSLLRDVFHTTVNFIN

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Fusion Gene PPI Analysis for ATP6V1E1-BID


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATP6V1E1-BID


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATP6V1E1-BID


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource