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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SIDT1-ERCC5 (FusionGDB2 ID:81825)

Fusion Gene Summary for SIDT1-ERCC5

check button Fusion gene summary
Fusion gene informationFusion gene name: SIDT1-ERCC5
Fusion gene ID: 81825
HgeneTgene
Gene symbol

SIDT1

ERCC5

Gene ID

54847

2073

Gene nameSID1 transmembrane family member 1ERCC excision repair 5, endonuclease
SynonymsSID-1|SID1COFS3|ERCC5-201|ERCM2|UVDR|XPG|XPGC
Cytomap

3q13.2

13q33.1

Type of geneprotein-codingprotein-coding
DescriptionSID1 transmembrane family member 1DNA repair protein complementing XP-G cellsDNA excision repair protein ERCC-5XPG-complementing proteinexcision repair cross-complementation group 5excision repair cross-complementing rodent repair deficiency, complementation group 5xeroderma pigmento
Modification date2020031320200322
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000264852, ENST00000393830, 
ENST00000463226, 		ENST00000375954, 
ENST00000472247, ENST00000355739, 
ENST00000535557, 
Fusion gene scores* DoF score4 X 4 X 2=322 X 1 X 2=4
# samples 42
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(2/4*10)=2.32192809488736
Context

PubMed: SIDT1 [Title/Abstract] AND ERCC5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSIDT1(113286557)-ERCC5(103506638), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneERCC5

GO:0006289

nucleotide-excision repair

11259578

TgeneERCC5

GO:0006295

nucleotide-excision repair, DNA incision, 3'-to lesion

8090225

TgeneERCC5

GO:0009411

response to UV

8710877


check buttonFusion gene breakpoints across SIDT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ERCC5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1JA-01ASIDT1chr3

113286557

+ERCC5chr13

103506638

+


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Fusion Gene ORF analysis for SIDT1-ERCC5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264852ENST00000375954SIDT1chr3

113286557

+ERCC5chr13

103506638

+
5CDS-intronENST00000264852ENST00000472247SIDT1chr3

113286557

+ERCC5chr13

103506638

+
5CDS-intronENST00000393830ENST00000375954SIDT1chr3

113286557

+ERCC5chr13

103506638

+
5CDS-intronENST00000393830ENST00000472247SIDT1chr3

113286557

+ERCC5chr13

103506638

+
In-frameENST00000264852ENST00000355739SIDT1chr3

113286557

+ERCC5chr13

103506638

+
In-frameENST00000264852ENST00000535557SIDT1chr3

113286557

+ERCC5chr13

103506638

+
In-frameENST00000393830ENST00000355739SIDT1chr3

113286557

+ERCC5chr13

103506638

+
In-frameENST00000393830ENST00000535557SIDT1chr3

113286557

+ERCC5chr13

103506638

+
intron-3CDSENST00000463226ENST00000355739SIDT1chr3

113286557

+ERCC5chr13

103506638

+
intron-3CDSENST00000463226ENST00000535557SIDT1chr3

113286557

+ERCC5chr13

103506638

+
intron-intronENST00000463226ENST00000375954SIDT1chr3

113286557

+ERCC5chr13

103506638

+
intron-intronENST00000463226ENST00000472247SIDT1chr3

113286557

+ERCC5chr13

103506638

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264852SIDT1chr3113286557+ENST00000355739ERCC5chr13103506638+4514124155244211289
ENST00000264852SIDT1chr3113286557+ENST00000535557ERCC5chr13103506638+156012415521559335
ENST00000393830SIDT1chr3113286557+ENST00000355739ERCC5chr13103506638+4439116647743461289
ENST00000393830SIDT1chr3113286557+ENST00000535557ERCC5chr13103506638+148511664771484335

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264852ENST00000355739SIDT1chr3113286557+ERCC5chr13103506638+0.0018988050.9981012
ENST00000264852ENST00000535557SIDT1chr3113286557+ERCC5chr13103506638+0.0053042870.9946957
ENST00000393830ENST00000355739SIDT1chr3113286557+ERCC5chr13103506638+0.0018843450.99811566
ENST00000393830ENST00000535557SIDT1chr3113286557+ERCC5chr13103506638+0.0065098210.9934902

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Fusion Genomic Features for SIDT1-ERCC5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SIDT1chr3113286557+ERCC5chr13103506637+0.0075815670.9924184
SIDT1chr3113286557+ERCC5chr13103506637+0.0075815670.9924184

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SIDT1-ERCC5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:113286557/chr13:103506638)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneERCC5chr3:113286557chr13:103506638ENST000003557392151057_10731261187.0MotifNuclear localization signal
TgeneERCC5chr3:113286557chr13:103506638ENST00000375954061057_10730420.0MotifNuclear localization signal
TgeneERCC5chr3:113286557chr13:103506638ENST00000355739215753_8811261187.0RegionNote=I-domain
TgeneERCC5chr3:113286557chr13:103506638ENST00000375954061_950420.0RegionNote=N-domain
TgeneERCC5chr3:113286557chr13:103506638ENST0000037595406753_8810420.0RegionNote=I-domain

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+32520_309171828.0Topological domainExtracellular
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325331_442171828.0Topological domainCytoplasmic
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325464_494171828.0Topological domainExtracellular
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325516_541171828.0Topological domainCytoplasmic
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325563_572171828.0Topological domainExtracellular
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325591_600171828.0Topological domainCytoplasmic
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325622_626171828.0Topological domainExtracellular
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325648_683171828.0Topological domainCytoplasmic
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325705_710171828.0Topological domainExtracellular
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325732_741171828.0Topological domainCytoplasmic
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325763_791171828.0Topological domainExtracellular
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325813_827171828.0Topological domainCytoplasmic
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325310_330171828.0TransmembraneHelical
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325443_463171828.0TransmembraneHelical
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325495_515171828.0TransmembraneHelical
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325542_562171828.0TransmembraneHelical
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325573_590171828.0TransmembraneHelical
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325601_621171828.0TransmembraneHelical
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325627_647171828.0TransmembraneHelical
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325684_704171828.0TransmembraneHelical
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325711_731171828.0TransmembraneHelical
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325742_762171828.0TransmembraneHelical
HgeneSIDT1chr3:113286557chr13:103506638ENST00000264852+325792_812171828.0TransmembraneHelical
TgeneERCC5chr3:113286557chr13:103506638ENST000003557392151_951261187.0RegionNote=N-domain


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Fusion Gene Sequence for SIDT1-ERCC5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81825_81825_1_SIDT1-ERCC5_SIDT1_chr3_113286557_ENST00000264852_ERCC5_chr13_103506638_ENST00000355739_length(transcript)=4514nt_BP=1241nt
ACATATTTACATACATACACATATGGTGAGGGAGAGAACGTGATGACGTGAGACTCTCCATGGAGAGTAGGAGGTAATAAAGAAATAAAA
CAGGTGTCTGAGGAGAGGTTCTATTAGAGAGGGGAGAATAGAGAGTAATTATCGTTCAGACAGGCAAGAGTTCTCTGCAGGTAGCAGCCT
GGGAAAGCGAACTCGCGCACCCTCTTGGGGGACGGGCTCTTTTGCTTTCTATTTCTTCTCCTGCAGCCAGGGTGCACACGTATTTGAAAC
AGACCGAATTTCCTCCTCGATGTGGCGTCAGGTTGACTTTTCGAGACTAGCGGGTATTTCTTTTTAATGACTCCAATGCCTTTTTATTAT
TGCTGTTATTGAGGTTGAGGGAGAAGAGATCGGTCTAAATTCTGGCTGGGTAAGTGGGGGGATTCTCGGCGATGAGAAACGGGGGACTTA
GAAGCCGGAGGAAAATCAGCAGCCCCACATCTCCACTTCTCCAGTCCGCCCTACTCTCCACCCGTGACCTCCAGTGGAGACCCCAGGCGG
CAGCATCAGTATTTGATCGGCCCTTCGTCAGCACGCTGCCAGCCCTGGCCGGCTGGGTTCGCCAGGCATCACCCGCTCGGCTCTGAAGCG
GACGCCTGGCCCTGCACCGGGCTTTGGAAGGACCCTCTCTGCGCTCGCCCCCTCCCCAGGGTGGCTCCGCTTTCGAGCCCGGGCGCGGTG
CCCACCATGCGCGGCTGCCTGCGGCTCGCGCTGCTCTGCGCGCTGCCCTGGCTCCTGCTGGCGGCGTCGCCCGGGCACCCGGCGAAATCC
CCCAGGCAGCCCCCGGCACCGCGCCGCGACCCCTTCGACGCTGCCAGGGGCGCCGATTTCGATCATGTCTACAGCGGGGTGGTGAACCTC
AGCACCGAGAACATCTACTCTTTCAACTACACCAGCCAGCCCGACCAGGTGACAGCCGTGAGGGTGTATGTGAACAGTTCCTCTGAGAAT
CTCAACTACCCGGTCCTTGTTGTGGTTCGCCAGCAGAAAGAGGTGCTGTCCTGGCAGGTTCCTCTGCTCTTCCAAGGACTATACCAGAGG
AGCTACAACTATCAAGAAGTGAGCCGCACCTTATGTCCCTCAGAAGCAACCAATGAGACGGGACCCTTGCAGCAACTGATATTTGTAGAT
GTCGCATCCATGGCACCCCTGGGTGCTCAGTACAAACTGCTAGTTACCAAGCTGAAGCACTTCCAGCTCCGAGATGAAGCACTACCCAGT
CTTACCCAAGTTCGAAGAGAAAACGACCTCTATGTTTTGCCTCCTTTACAAGAGGAAGAAAAACACAGTTCAGAAGAGGAAGATGAAAAA
GAATGGCAAGAAAGAATGAATCAAAAACAAGCATTACAGGAAGAGTTCTTTCATAATCCTCAAGCGATAGATATTGAGTCTGAGGACTTC
AGCAGCCTGCCCCCTGAAGTAAAGCATGAAATCTTGACTGATATGAAAGAGTTCACCAAGCGCAGAAGAACATTATTTGAAGCAATGCCA
GAGGAGTCTGATGACTTTTCACAGTACCAACTCAAAGGCTTGCTTAAAAAGAACTATCTGAACCAGCATATAGAACATGTCCAAAAGGAA
ATGAATCAGCAACATTCAGGACACATCCGAAGGCAGTATGAAGATGAAGGGGGCTTTCTGAAGGAGGTAGAGTCAAGGAGAGTGGTCTCT
GAAGACACTTCACATTACATCTTGATAAAAGGTATTCAAGCTAAGACAGTTGCAGAAGTGGATTCAGAGTCTCTTCCTTCTTCCAGCAAA
ATGCACGGCATGTCTTTTGACGTGAAGTCATCTCCATGTGAAAAACTGAAGACAGAGAAAGAGCCTGATGCTACCCCTCCTTCTCCAAGA
ACTTTACTAGCTATGCAAGCTGCCCTGCTGGGAAGTAGCTCAGAAGAGGAGCTGGAGAGTGAAAATCGAAGGCAGGCCCGTGGGAGGAAC
GCACCTGCTGCTGTAGACGAAGGCTCCATATCACCCCGGACTCTTTCAGCCATTAAGAGAGCTCTTGACGATGACGAAGATGTAAAAGTG
TGTGCTGGGGATGATGTGCAGACGGGAGGGCCAGGAGCAGAAGAAATGCGTATAAACAGCTCCACCGAGAACAGTGATGAAGGACTTAAA
GTGAGAGATGGAAAAGGAATACCGTTTACTGCAACACTTGCGTCATCTAGTGTGAACTCTGCAGAGGAGCACGTAGCCAGCACTAATGAG
GGGAGAGAGCCCACAGACTCAGTTCCAAAAGAACAAATGTCACTTGTTCACGTGGGGACTGAAGCCTTTCCGATAAGTGATGAGTCTATG
ATTAAGGACAGAAAAGATCGGCTGCCTCTGGAGAGTGCAGTGGTTAGACATAGTGACGCACCTGGGCTCCCGAATGGAAGGGAACTGACA
CCGGCATCTCCAACTTGTACAAATTCTGTGTCAAAGAATGAAACACATGCTGAAGTGCTTGAGCAGCAGAACGAACTTTGCCCATATGAG
AGTAAATTCGATTCTTCTCTTCTTTCAAGTGATGATGAAACAAAATGTAAACCGAATTCTGCTTCTGAAGTCATTGGCCCTGTCAGTTTG
CAAGAAACAAGTAGCATAGTAAGTGTCCCTTCAGAGGCAGTAGATAATGTGGAAAATGTGGTGTCATTTAATGCTAAAGAGCATGAGAAT
TTTCTGGAAACCATCCAAGAACAGCAGACCACTGAATCTGCAGGCCAGGATTTAATTTCCATTCCAAAGGCCGTGGAACCAATGGAAATT
GACTCGGAAGAAAGTGAATCTGATGGAAGTTTCATTGAAGTGCAAAGTGTGATTAGTGATGAGGAACTTCAAGCAGAATTCCCTGAAACT
TCCAAACCTCCCTCAGAACAAGGCGAAGAGGAACTGGTAGGAACTAGGGAGGGAGAAGCCCCTGCTGAGTCCGAGAGCCTCCTGAGGGAC
AACTCTGAGAGGGACGACGTGGATGGTGAGCCACAGGAAGCTGAGAAAGATGCGGAAGATTCGCTCCATGAATGGCAAGATATTAATTTG
GAGGAGTTGGAAACTCTGGAGAGCAACCTCTTAGCACAGCAGAATTCACTGAAAGCTCAAAAACAGCAGCAAGAACGGATCGCTGCTACT
GTCACCGGACAGATGTTCCTGGAAAGCCAGGAACTCCTGCGCCTGTTCGGCATTCCCTACATCCAGGCTCCCATGGAAGCAGAGGCGCAG
TGCGCCATCCTGGACCTGACTGATCAGACTTCCGGAACCATCACTGATGACAGTGATATCTGGCTGTTTGGAGCGCGGCATGTCTATAGA
AACTTTTTTAATAAAAACAAGTTTGTAGAATATTATCAATATGTGGACTTTCACAATCAATTGGGATTGGACCGGAATAAGTTAATAAAT
TTGGCTTATTTGCTTGGAAGTGATTATACCGAAGGAATACCAACTGTGGGTTGTGTAACCGCCATGGAAATTCTCAATGAATTCCCTGGG
CATGGCCTGGAACCTCTCCTAAAATTCTCAGAATGGTGGCATGAAGCTCAAAAAAATCCAAAGATAAGACCTAATCCTCATGACACCAAA
GTGAAAAAAAAATTACGGACATTGCAACTCACCCCTGGCTTTCCTAACCCAGCTGTTGCCGAGGCCTACCTCAAACCCGTGGTGGATGAC
TCGAAGGGATCCTTTCTGTGGGGGAAACCTGATCTCGACAAAATTAGAGAATTTTGTCAGCGGTATTTCGGCTGGAACAGAACGAAGACA
GATGAATCTCTGTTTCCTGTATTAAAGCAACTCGATGCCCAGCAGACACAGCTCCGAATTGATTCCTTCTTTAGATTAGCACAACAGGAG
AAAGAAGATGCTAAACGTATTAAGAGCCAGAGACTAAACAGAGCTGTGACATGTATGCTAAGGAAAGAGAAAGAAGCAGCAGCCAGCGAA
ATAGAAGCAGTTTCTGTTGCCATGGAGAAAGAATTTGAGCTACTTGATAAGGCAAAAGGAAAAACCCAGAAGAGAGGCATAACAAATACC
TTAGAAGAGTCATCAAGCCTGAAAAGAAAGAGGCTTTCAGATTCTAAAGGAAAGAATACATGCGGTGGATTTTTGGGGGAGACCTGCCTC
TCAGAATCATCTGATGGATCTTCAAGTGAAGATGCTGAAAGTTCATCTTTAATGAATGTACAAAGGAGAACAGCTGCGAAAGAGCCAAAA
ACCAGTGCTTCAGATTCGCAGAACTCAGTGAAGGAAGCTCCCGTGAAGAATGGAGGTGCGACCACCAGCAGCTCTAGTGATAGTGATGAC
GATGGAGGGAAAGAGAAGATGGTCCTCGTGACCGCCAGATCTGTGTTTGGGAAGAAAAGAAGGAAACTAAGACGTGCGAGGGGAAGAAAA
AGGAAAACCTAATTAAAAAATATGTATCCTCTATAATTAGTTATGACAGCCATTTGTAATGAATTTGTCGCAAAGACGTAATAAAATTAA

>81825_81825_1_SIDT1-ERCC5_SIDT1_chr3_113286557_ENST00000264852_ERCC5_chr13_103506638_ENST00000355739_length(amino acids)=1289AA_BP=229
MIGPSSARCQPWPAGFARHHPLGSEADAWPCTGLWKDPLCARPLPRVAPLSSPGAVPTMRGCLRLALLCALPWLLLAASPGHPAKSPRQP
PAPRRDPFDAARGADFDHVYSGVVNLSTENIYSFNYTSQPDQVTAVRVYVNSSSENLNYPVLVVVRQQKEVLSWQVPLLFQGLYQRSYNY
QEVSRTLCPSEATNETGPLQQLIFVDVASMAPLGAQYKLLVTKLKHFQLRDEALPSLTQVRRENDLYVLPPLQEEEKHSSEEEDEKEWQE
RMNQKQALQEEFFHNPQAIDIESEDFSSLPPEVKHEILTDMKEFTKRRRTLFEAMPEESDDFSQYQLKGLLKKNYLNQHIEHVQKEMNQQ
HSGHIRRQYEDEGGFLKEVESRRVVSEDTSHYILIKGIQAKTVAEVDSESLPSSSKMHGMSFDVKSSPCEKLKTEKEPDATPPSPRTLLA
MQAALLGSSSEEELESENRRQARGRNAPAAVDEGSISPRTLSAIKRALDDDEDVKVCAGDDVQTGGPGAEEMRINSSTENSDEGLKVRDG
KGIPFTATLASSSVNSAEEHVASTNEGREPTDSVPKEQMSLVHVGTEAFPISDESMIKDRKDRLPLESAVVRHSDAPGLPNGRELTPASP
TCTNSVSKNETHAEVLEQQNELCPYESKFDSSLLSSDDETKCKPNSASEVIGPVSLQETSSIVSVPSEAVDNVENVVSFNAKEHENFLET
IQEQQTTESAGQDLISIPKAVEPMEIDSEESESDGSFIEVQSVISDEELQAEFPETSKPPSEQGEEELVGTREGEAPAESESLLRDNSER
DDVDGEPQEAEKDAEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFLESQELLRLFGIPYIQAPMEAEAQCAIL
DLTDQTSGTITDDSDIWLFGARHVYRNFFNKNKFVEYYQYVDFHNQLGLDRNKLINLAYLLGSDYTEGIPTVGCVTAMEILNEFPGHGLE
PLLKFSEWWHEAQKNPKIRPNPHDTKVKKKLRTLQLTPGFPNPAVAEAYLKPVVDDSKGSFLWGKPDLDKIREFCQRYFGWNRTKTDESL
FPVLKQLDAQQTQLRIDSFFRLAQQEKEDAKRIKSQRLNRAVTCMLRKEKEAAASEIEAVSVAMEKEFELLDKAKGKTQKRGITNTLEES
SSLKRKRLSDSKGKNTCGGFLGETCLSESSDGSSSEDAESSSLMNVQRRTAAKEPKTSASDSQNSVKEAPVKNGGATTSSSSDSDDDGGK

--------------------------------------------------------------
>81825_81825_2_SIDT1-ERCC5_SIDT1_chr3_113286557_ENST00000264852_ERCC5_chr13_103506638_ENST00000535557_length(transcript)=1560nt_BP=1241nt
ACATATTTACATACATACACATATGGTGAGGGAGAGAACGTGATGACGTGAGACTCTCCATGGAGAGTAGGAGGTAATAAAGAAATAAAA
CAGGTGTCTGAGGAGAGGTTCTATTAGAGAGGGGAGAATAGAGAGTAATTATCGTTCAGACAGGCAAGAGTTCTCTGCAGGTAGCAGCCT
GGGAAAGCGAACTCGCGCACCCTCTTGGGGGACGGGCTCTTTTGCTTTCTATTTCTTCTCCTGCAGCCAGGGTGCACACGTATTTGAAAC
AGACCGAATTTCCTCCTCGATGTGGCGTCAGGTTGACTTTTCGAGACTAGCGGGTATTTCTTTTTAATGACTCCAATGCCTTTTTATTAT
TGCTGTTATTGAGGTTGAGGGAGAAGAGATCGGTCTAAATTCTGGCTGGGTAAGTGGGGGGATTCTCGGCGATGAGAAACGGGGGACTTA
GAAGCCGGAGGAAAATCAGCAGCCCCACATCTCCACTTCTCCAGTCCGCCCTACTCTCCACCCGTGACCTCCAGTGGAGACCCCAGGCGG
CAGCATCAGTATTTGATCGGCCCTTCGTCAGCACGCTGCCAGCCCTGGCCGGCTGGGTTCGCCAGGCATCACCCGCTCGGCTCTGAAGCG
GACGCCTGGCCCTGCACCGGGCTTTGGAAGGACCCTCTCTGCGCTCGCCCCCTCCCCAGGGTGGCTCCGCTTTCGAGCCCGGGCGCGGTG
CCCACCATGCGCGGCTGCCTGCGGCTCGCGCTGCTCTGCGCGCTGCCCTGGCTCCTGCTGGCGGCGTCGCCCGGGCACCCGGCGAAATCC
CCCAGGCAGCCCCCGGCACCGCGCCGCGACCCCTTCGACGCTGCCAGGGGCGCCGATTTCGATCATGTCTACAGCGGGGTGGTGAACCTC
AGCACCGAGAACATCTACTCTTTCAACTACACCAGCCAGCCCGACCAGGTGACAGCCGTGAGGGTGTATGTGAACAGTTCCTCTGAGAAT
CTCAACTACCCGGTCCTTGTTGTGGTTCGCCAGCAGAAAGAGGTGCTGTCCTGGCAGGTTCCTCTGCTCTTCCAAGGACTATACCAGAGG
AGCTACAACTATCAAGAAGTGAGCCGCACCTTATGTCCCTCAGAAGCAACCAATGAGACGGGACCCTTGCAGCAACTGATATTTGTAGAT
GTCGCATCCATGGCACCCCTGGGTGCTCAGTACAAACTGCTAGTTACCAAGCTGAAGCACTTCCAGCTCCGAGATGAAGCACTACCCAGT
CTTACCCAAGTTCGAAGAGAAAACGACCTCTATGTTTTGCCTCCTTTACAAGAGGAAGAAAAACACAGTTCAGAAGAGGAAGATGAAAAA
GAATGGCAAGAAAGAATGAATCAAAAACAAGCATTACAGGAAGAGTTCTTTCATAATCCTCAAGCGATAGATATTGAGTCTGAGGACTTC
AGCAGCCTGCCCCCTGAAGTAAAGCATGAAATCTTGACTGATATGAAAGAGTTCACCAAGCGCAGAAGAACATTATTTGAAGCAATGCCA

>81825_81825_2_SIDT1-ERCC5_SIDT1_chr3_113286557_ENST00000264852_ERCC5_chr13_103506638_ENST00000535557_length(amino acids)=335AA_BP=229
MIGPSSARCQPWPAGFARHHPLGSEADAWPCTGLWKDPLCARPLPRVAPLSSPGAVPTMRGCLRLALLCALPWLLLAASPGHPAKSPRQP
PAPRRDPFDAARGADFDHVYSGVVNLSTENIYSFNYTSQPDQVTAVRVYVNSSSENLNYPVLVVVRQQKEVLSWQVPLLFQGLYQRSYNY
QEVSRTLCPSEATNETGPLQQLIFVDVASMAPLGAQYKLLVTKLKHFQLRDEALPSLTQVRRENDLYVLPPLQEEEKHSSEEEDEKEWQE

--------------------------------------------------------------
>81825_81825_3_SIDT1-ERCC5_SIDT1_chr3_113286557_ENST00000393830_ERCC5_chr13_103506638_ENST00000355739_length(transcript)=4439nt_BP=1166nt
AATAAAGAAATAAAACAGGTGTCTGAGGAGAGGTTCTATTAGAGAGGGGAGAATAGAGAGTAATTATCGTTCAGACAGGCAAGAGTTCTC
TGCAGGTAGCAGCCTGGGAAAGCGAACTCGCGCACCCTCTTGGGGGACGGGCTCTTTTGCTTTCTATTTCTTCTCCTGCAGCCAGGGTGC
ACACGTATTTGAAACAGACCGAATTTCCTCCTCGATGTGGCGTCAGGTTGACTTTTCGAGACTAGCGGGTATTTCTTTTTAATGACTCCA
ATGCCTTTTTATTATTGCTGTTATTGAGGTTGAGGGAGAAGAGATCGGTCTAAATTCTGGCTGGGTAAGTGGGGGGATTCTCGGCGATGA
GAAACGGGGGACTTAGAAGCCGGAGGAAAATCAGCAGCCCCACATCTCCACTTCTCCAGTCCGCCCTACTCTCCACCCGTGACCTCCAGT
GGAGACCCCAGGCGGCAGCATCAGTATTTGATCGGCCCTTCGTCAGCACGCTGCCAGCCCTGGCCGGCTGGGTTCGCCAGGCATCACCCG
CTCGGCTCTGAAGCGGACGCCTGGCCCTGCACCGGGCTTTGGAAGGACCCTCTCTGCGCTCGCCCCCTCCCCAGGGTGGCTCCGCTTTCG
AGCCCGGGCGCGGTGCCCACCATGCGCGGCTGCCTGCGGCTCGCGCTGCTCTGCGCGCTGCCCTGGCTCCTGCTGGCGGCGTCGCCCGGG
CACCCGGCGAAATCCCCCAGGCAGCCCCCGGCACCGCGCCGCGACCCCTTCGACGCTGCCAGGGGCGCCGATTTCGATCATGTCTACAGC
GGGGTGGTGAACCTCAGCACCGAGAACATCTACTCTTTCAACTACACCAGCCAGCCCGACCAGGTGACAGCCGTGAGGGTGTATGTGAAC
AGTTCCTCTGAGAATCTCAACTACCCGGTCCTTGTTGTGGTTCGCCAGCAGAAAGAGGTGCTGTCCTGGCAGGTTCCTCTGCTCTTCCAA
GGACTATACCAGAGGAGCTACAACTATCAAGAAGTGAGCCGCACCTTATGTCCCTCAGAAGCAACCAATGAGACGGGACCCTTGCAGCAA
CTGATATTTGTAGATGTCGCATCCATGGCACCCCTGGGTGCTCAGTACAAACTGCTAGTTACCAAGCTGAAGCACTTCCAGCTCCGAGAT
GAAGCACTACCCAGTCTTACCCAAGTTCGAAGAGAAAACGACCTCTATGTTTTGCCTCCTTTACAAGAGGAAGAAAAACACAGTTCAGAA
GAGGAAGATGAAAAAGAATGGCAAGAAAGAATGAATCAAAAACAAGCATTACAGGAAGAGTTCTTTCATAATCCTCAAGCGATAGATATT
GAGTCTGAGGACTTCAGCAGCCTGCCCCCTGAAGTAAAGCATGAAATCTTGACTGATATGAAAGAGTTCACCAAGCGCAGAAGAACATTA
TTTGAAGCAATGCCAGAGGAGTCTGATGACTTTTCACAGTACCAACTCAAAGGCTTGCTTAAAAAGAACTATCTGAACCAGCATATAGAA
CATGTCCAAAAGGAAATGAATCAGCAACATTCAGGACACATCCGAAGGCAGTATGAAGATGAAGGGGGCTTTCTGAAGGAGGTAGAGTCA
AGGAGAGTGGTCTCTGAAGACACTTCACATTACATCTTGATAAAAGGTATTCAAGCTAAGACAGTTGCAGAAGTGGATTCAGAGTCTCTT
CCTTCTTCCAGCAAAATGCACGGCATGTCTTTTGACGTGAAGTCATCTCCATGTGAAAAACTGAAGACAGAGAAAGAGCCTGATGCTACC
CCTCCTTCTCCAAGAACTTTACTAGCTATGCAAGCTGCCCTGCTGGGAAGTAGCTCAGAAGAGGAGCTGGAGAGTGAAAATCGAAGGCAG
GCCCGTGGGAGGAACGCACCTGCTGCTGTAGACGAAGGCTCCATATCACCCCGGACTCTTTCAGCCATTAAGAGAGCTCTTGACGATGAC
GAAGATGTAAAAGTGTGTGCTGGGGATGATGTGCAGACGGGAGGGCCAGGAGCAGAAGAAATGCGTATAAACAGCTCCACCGAGAACAGT
GATGAAGGACTTAAAGTGAGAGATGGAAAAGGAATACCGTTTACTGCAACACTTGCGTCATCTAGTGTGAACTCTGCAGAGGAGCACGTA
GCCAGCACTAATGAGGGGAGAGAGCCCACAGACTCAGTTCCAAAAGAACAAATGTCACTTGTTCACGTGGGGACTGAAGCCTTTCCGATA
AGTGATGAGTCTATGATTAAGGACAGAAAAGATCGGCTGCCTCTGGAGAGTGCAGTGGTTAGACATAGTGACGCACCTGGGCTCCCGAAT
GGAAGGGAACTGACACCGGCATCTCCAACTTGTACAAATTCTGTGTCAAAGAATGAAACACATGCTGAAGTGCTTGAGCAGCAGAACGAA
CTTTGCCCATATGAGAGTAAATTCGATTCTTCTCTTCTTTCAAGTGATGATGAAACAAAATGTAAACCGAATTCTGCTTCTGAAGTCATT
GGCCCTGTCAGTTTGCAAGAAACAAGTAGCATAGTAAGTGTCCCTTCAGAGGCAGTAGATAATGTGGAAAATGTGGTGTCATTTAATGCT
AAAGAGCATGAGAATTTTCTGGAAACCATCCAAGAACAGCAGACCACTGAATCTGCAGGCCAGGATTTAATTTCCATTCCAAAGGCCGTG
GAACCAATGGAAATTGACTCGGAAGAAAGTGAATCTGATGGAAGTTTCATTGAAGTGCAAAGTGTGATTAGTGATGAGGAACTTCAAGCA
GAATTCCCTGAAACTTCCAAACCTCCCTCAGAACAAGGCGAAGAGGAACTGGTAGGAACTAGGGAGGGAGAAGCCCCTGCTGAGTCCGAG
AGCCTCCTGAGGGACAACTCTGAGAGGGACGACGTGGATGGTGAGCCACAGGAAGCTGAGAAAGATGCGGAAGATTCGCTCCATGAATGG
CAAGATATTAATTTGGAGGAGTTGGAAACTCTGGAGAGCAACCTCTTAGCACAGCAGAATTCACTGAAAGCTCAAAAACAGCAGCAAGAA
CGGATCGCTGCTACTGTCACCGGACAGATGTTCCTGGAAAGCCAGGAACTCCTGCGCCTGTTCGGCATTCCCTACATCCAGGCTCCCATG
GAAGCAGAGGCGCAGTGCGCCATCCTGGACCTGACTGATCAGACTTCCGGAACCATCACTGATGACAGTGATATCTGGCTGTTTGGAGCG
CGGCATGTCTATAGAAACTTTTTTAATAAAAACAAGTTTGTAGAATATTATCAATATGTGGACTTTCACAATCAATTGGGATTGGACCGG
AATAAGTTAATAAATTTGGCTTATTTGCTTGGAAGTGATTATACCGAAGGAATACCAACTGTGGGTTGTGTAACCGCCATGGAAATTCTC
AATGAATTCCCTGGGCATGGCCTGGAACCTCTCCTAAAATTCTCAGAATGGTGGCATGAAGCTCAAAAAAATCCAAAGATAAGACCTAAT
CCTCATGACACCAAAGTGAAAAAAAAATTACGGACATTGCAACTCACCCCTGGCTTTCCTAACCCAGCTGTTGCCGAGGCCTACCTCAAA
CCCGTGGTGGATGACTCGAAGGGATCCTTTCTGTGGGGGAAACCTGATCTCGACAAAATTAGAGAATTTTGTCAGCGGTATTTCGGCTGG
AACAGAACGAAGACAGATGAATCTCTGTTTCCTGTATTAAAGCAACTCGATGCCCAGCAGACACAGCTCCGAATTGATTCCTTCTTTAGA
TTAGCACAACAGGAGAAAGAAGATGCTAAACGTATTAAGAGCCAGAGACTAAACAGAGCTGTGACATGTATGCTAAGGAAAGAGAAAGAA
GCAGCAGCCAGCGAAATAGAAGCAGTTTCTGTTGCCATGGAGAAAGAATTTGAGCTACTTGATAAGGCAAAAGGAAAAACCCAGAAGAGA
GGCATAACAAATACCTTAGAAGAGTCATCAAGCCTGAAAAGAAAGAGGCTTTCAGATTCTAAAGGAAAGAATACATGCGGTGGATTTTTG
GGGGAGACCTGCCTCTCAGAATCATCTGATGGATCTTCAAGTGAAGATGCTGAAAGTTCATCTTTAATGAATGTACAAAGGAGAACAGCT
GCGAAAGAGCCAAAAACCAGTGCTTCAGATTCGCAGAACTCAGTGAAGGAAGCTCCCGTGAAGAATGGAGGTGCGACCACCAGCAGCTCT
AGTGATAGTGATGACGATGGAGGGAAAGAGAAGATGGTCCTCGTGACCGCCAGATCTGTGTTTGGGAAGAAAAGAAGGAAACTAAGACGT
GCGAGGGGAAGAAAAAGGAAAACCTAATTAAAAAATATGTATCCTCTATAATTAGTTATGACAGCCATTTGTAATGAATTTGTCGCAAAG

>81825_81825_3_SIDT1-ERCC5_SIDT1_chr3_113286557_ENST00000393830_ERCC5_chr13_103506638_ENST00000355739_length(amino acids)=1289AA_BP=229
MIGPSSARCQPWPAGFARHHPLGSEADAWPCTGLWKDPLCARPLPRVAPLSSPGAVPTMRGCLRLALLCALPWLLLAASPGHPAKSPRQP
PAPRRDPFDAARGADFDHVYSGVVNLSTENIYSFNYTSQPDQVTAVRVYVNSSSENLNYPVLVVVRQQKEVLSWQVPLLFQGLYQRSYNY
QEVSRTLCPSEATNETGPLQQLIFVDVASMAPLGAQYKLLVTKLKHFQLRDEALPSLTQVRRENDLYVLPPLQEEEKHSSEEEDEKEWQE
RMNQKQALQEEFFHNPQAIDIESEDFSSLPPEVKHEILTDMKEFTKRRRTLFEAMPEESDDFSQYQLKGLLKKNYLNQHIEHVQKEMNQQ
HSGHIRRQYEDEGGFLKEVESRRVVSEDTSHYILIKGIQAKTVAEVDSESLPSSSKMHGMSFDVKSSPCEKLKTEKEPDATPPSPRTLLA
MQAALLGSSSEEELESENRRQARGRNAPAAVDEGSISPRTLSAIKRALDDDEDVKVCAGDDVQTGGPGAEEMRINSSTENSDEGLKVRDG
KGIPFTATLASSSVNSAEEHVASTNEGREPTDSVPKEQMSLVHVGTEAFPISDESMIKDRKDRLPLESAVVRHSDAPGLPNGRELTPASP
TCTNSVSKNETHAEVLEQQNELCPYESKFDSSLLSSDDETKCKPNSASEVIGPVSLQETSSIVSVPSEAVDNVENVVSFNAKEHENFLET
IQEQQTTESAGQDLISIPKAVEPMEIDSEESESDGSFIEVQSVISDEELQAEFPETSKPPSEQGEEELVGTREGEAPAESESLLRDNSER
DDVDGEPQEAEKDAEDSLHEWQDINLEELETLESNLLAQQNSLKAQKQQQERIAATVTGQMFLESQELLRLFGIPYIQAPMEAEAQCAIL
DLTDQTSGTITDDSDIWLFGARHVYRNFFNKNKFVEYYQYVDFHNQLGLDRNKLINLAYLLGSDYTEGIPTVGCVTAMEILNEFPGHGLE
PLLKFSEWWHEAQKNPKIRPNPHDTKVKKKLRTLQLTPGFPNPAVAEAYLKPVVDDSKGSFLWGKPDLDKIREFCQRYFGWNRTKTDESL
FPVLKQLDAQQTQLRIDSFFRLAQQEKEDAKRIKSQRLNRAVTCMLRKEKEAAASEIEAVSVAMEKEFELLDKAKGKTQKRGITNTLEES
SSLKRKRLSDSKGKNTCGGFLGETCLSESSDGSSSEDAESSSLMNVQRRTAAKEPKTSASDSQNSVKEAPVKNGGATTSSSSDSDDDGGK

--------------------------------------------------------------
>81825_81825_4_SIDT1-ERCC5_SIDT1_chr3_113286557_ENST00000393830_ERCC5_chr13_103506638_ENST00000535557_length(transcript)=1485nt_BP=1166nt
AATAAAGAAATAAAACAGGTGTCTGAGGAGAGGTTCTATTAGAGAGGGGAGAATAGAGAGTAATTATCGTTCAGACAGGCAAGAGTTCTC
TGCAGGTAGCAGCCTGGGAAAGCGAACTCGCGCACCCTCTTGGGGGACGGGCTCTTTTGCTTTCTATTTCTTCTCCTGCAGCCAGGGTGC
ACACGTATTTGAAACAGACCGAATTTCCTCCTCGATGTGGCGTCAGGTTGACTTTTCGAGACTAGCGGGTATTTCTTTTTAATGACTCCA
ATGCCTTTTTATTATTGCTGTTATTGAGGTTGAGGGAGAAGAGATCGGTCTAAATTCTGGCTGGGTAAGTGGGGGGATTCTCGGCGATGA
GAAACGGGGGACTTAGAAGCCGGAGGAAAATCAGCAGCCCCACATCTCCACTTCTCCAGTCCGCCCTACTCTCCACCCGTGACCTCCAGT
GGAGACCCCAGGCGGCAGCATCAGTATTTGATCGGCCCTTCGTCAGCACGCTGCCAGCCCTGGCCGGCTGGGTTCGCCAGGCATCACCCG
CTCGGCTCTGAAGCGGACGCCTGGCCCTGCACCGGGCTTTGGAAGGACCCTCTCTGCGCTCGCCCCCTCCCCAGGGTGGCTCCGCTTTCG
AGCCCGGGCGCGGTGCCCACCATGCGCGGCTGCCTGCGGCTCGCGCTGCTCTGCGCGCTGCCCTGGCTCCTGCTGGCGGCGTCGCCCGGG
CACCCGGCGAAATCCCCCAGGCAGCCCCCGGCACCGCGCCGCGACCCCTTCGACGCTGCCAGGGGCGCCGATTTCGATCATGTCTACAGC
GGGGTGGTGAACCTCAGCACCGAGAACATCTACTCTTTCAACTACACCAGCCAGCCCGACCAGGTGACAGCCGTGAGGGTGTATGTGAAC
AGTTCCTCTGAGAATCTCAACTACCCGGTCCTTGTTGTGGTTCGCCAGCAGAAAGAGGTGCTGTCCTGGCAGGTTCCTCTGCTCTTCCAA
GGACTATACCAGAGGAGCTACAACTATCAAGAAGTGAGCCGCACCTTATGTCCCTCAGAAGCAACCAATGAGACGGGACCCTTGCAGCAA
CTGATATTTGTAGATGTCGCATCCATGGCACCCCTGGGTGCTCAGTACAAACTGCTAGTTACCAAGCTGAAGCACTTCCAGCTCCGAGAT
GAAGCACTACCCAGTCTTACCCAAGTTCGAAGAGAAAACGACCTCTATGTTTTGCCTCCTTTACAAGAGGAAGAAAAACACAGTTCAGAA
GAGGAAGATGAAAAAGAATGGCAAGAAAGAATGAATCAAAAACAAGCATTACAGGAAGAGTTCTTTCATAATCCTCAAGCGATAGATATT
GAGTCTGAGGACTTCAGCAGCCTGCCCCCTGAAGTAAAGCATGAAATCTTGACTGATATGAAAGAGTTCACCAAGCGCAGAAGAACATTA

>81825_81825_4_SIDT1-ERCC5_SIDT1_chr3_113286557_ENST00000393830_ERCC5_chr13_103506638_ENST00000535557_length(amino acids)=335AA_BP=229
MIGPSSARCQPWPAGFARHHPLGSEADAWPCTGLWKDPLCARPLPRVAPLSSPGAVPTMRGCLRLALLCALPWLLLAASPGHPAKSPRQP
PAPRRDPFDAARGADFDHVYSGVVNLSTENIYSFNYTSQPDQVTAVRVYVNSSSENLNYPVLVVVRQQKEVLSWQVPLLFQGLYQRSYNY
QEVSRTLCPSEATNETGPLQQLIFVDVASMAPLGAQYKLLVTKLKHFQLRDEALPSLTQVRRENDLYVLPPLQEEEKHSSEEEDEKEWQE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SIDT1-ERCC5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneERCC5chr3:113286557chr13:103506638ENST00000355739215981_1009126.666666666666671187.0PCNA
TgeneERCC5chr3:113286557chr13:103506638ENST0000037595406981_10090420.0PCNA


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SIDT1-ERCC5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SIDT1-ERCC5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource