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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SIDT2-CYP2C8 (FusionGDB2 ID:81829)

Fusion Gene Summary for SIDT2-CYP2C8

Fusion gene summary

Fusion gene information	Fusion gene name: SIDT2-CYP2C8
	Fusion gene ID: 81829
		Hgene	Tgene
	Gene symbol	SIDT2	CYP2C8
	Gene ID	51092	1558
	Gene name	SID1 transmembrane family member 2	cytochrome P450 family 2 subfamily C member 8
	Synonyms	CGI-40	CPC8\|CYP2C8DM\|CYPIIC8\|MP-12/MP-20
	Cytomap	11q23.3	10q23.33
	Type of gene	protein-coding	protein-coding
	Description	SID1 transmembrane family member 2	cytochrome P450 2C8P450 form 1cytochrome P450 IIC2cytochrome P450 MP-12cytochrome P450 MP-20cytochrome P450 form 1cytochrome P450, family 2, subfamily C, polypeptide 8cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8flavopr
	Modification date	20200313	20200320
	UniProtAcc	.	P10632
	Ensembl transtripts involved in fusion gene	ENST00000324225, ENST00000431081, ENST00000532062, ENST00000530948,	ENST00000539050, ENST00000535898, ENST00000371270,
Fusion gene scores	* DoF score	4 X 4 X 2=32	6 X 2 X 5=60
	# samples	4	6
	** MAII score	log2(4/32*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/60*10)=0
Context	PubMed: SIDT2 [Title/Abstract] AND CYP2C8 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SIDT2(117064679)-CYP2C8(96827448), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SIDT2	GO:0050658	RNA transport	28277980
Tgene	CYP2C8	GO:0002933	lipid hydroxylation	14559847
Tgene	CYP2C8	GO:0006082	organic acid metabolic process	19651758
Tgene	CYP2C8	GO:0008202	steroid metabolic process	14559847
Tgene	CYP2C8	GO:0008210	estrogen metabolic process	12865317\|14559847
Tgene	CYP2C8	GO:0017144	drug metabolic process	19651758
Tgene	CYP2C8	GO:0019373	epoxygenase P450 pathway	7574697
Tgene	CYP2C8	GO:0042573	retinoic acid metabolic process	11093772
Tgene	CYP2C8	GO:0042738	exogenous drug catabolic process	18619574
Tgene	CYP2C8	GO:0046456	icosanoid biosynthetic process	15766564
Tgene	CYP2C8	GO:0055114	oxidation-reduction process	19651758
Tgene	CYP2C8	GO:0070989	oxidative demethylation	18619574

Fusion gene breakpoints across SIDT2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CYP2C8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	THCA	TCGA-EL-A3CP	SIDT2	chr11	117064679	+	CYP2C8	chr10	96827448	-

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Fusion Gene ORF analysis for SIDT2-CYP2C8

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000324225	ENST00000539050	SIDT2	chr11	117064679	+	CYP2C8	chr10	96827448	-
5CDS-5UTR	ENST00000431081	ENST00000539050	SIDT2	chr11	117064679	+	CYP2C8	chr10	96827448	-
5CDS-5UTR	ENST00000532062	ENST00000539050	SIDT2	chr11	117064679	+	CYP2C8	chr10	96827448	-
5CDS-intron	ENST00000324225	ENST00000535898	SIDT2	chr11	117064679	+	CYP2C8	chr10	96827448	-
5CDS-intron	ENST00000431081	ENST00000535898	SIDT2	chr11	117064679	+	CYP2C8	chr10	96827448	-
5CDS-intron	ENST00000532062	ENST00000535898	SIDT2	chr11	117064679	+	CYP2C8	chr10	96827448	-
In-frame	ENST00000324225	ENST00000371270	SIDT2	chr11	117064679	+	CYP2C8	chr10	96827448	-
In-frame	ENST00000431081	ENST00000371270	SIDT2	chr11	117064679	+	CYP2C8	chr10	96827448	-
In-frame	ENST00000532062	ENST00000371270	SIDT2	chr11	117064679	+	CYP2C8	chr10	96827448	-
intron-3CDS	ENST00000530948	ENST00000371270	SIDT2	chr11	117064679	+	CYP2C8	chr10	96827448	-
intron-5UTR	ENST00000530948	ENST00000539050	SIDT2	chr11	117064679	+	CYP2C8	chr10	96827448	-
intron-intron	ENST00000530948	ENST00000535898	SIDT2	chr11	117064679	+	CYP2C8	chr10	96827448	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000324225	SIDT2	chr11	117064679	+	ENST00000371270	CYP2C8	chr10	96827448	-	4513	2853	531	4157	1208
ENST00000431081	SIDT2	chr11	117064679	+	ENST00000371270	CYP2C8	chr10	96827448	-	4043	2383	70	3687	1205
ENST00000532062	SIDT2	chr11	117064679	+	ENST00000371270	CYP2C8	chr10	96827448	-	2413	753	555	2057	500

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000324225	ENST00000371270	SIDT2	chr11	117064679	+	CYP2C8	chr10	96827448	-	0.00081154	0.9991885
ENST00000431081	ENST00000371270	SIDT2	chr11	117064679	+	CYP2C8	chr10	96827448	-	0.000265441	0.9997346
ENST00000532062	ENST00000371270	SIDT2	chr11	117064679	+	CYP2C8	chr10	96827448	-	0.001072549	0.9989274

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Fusion Genomic Features for SIDT2-CYP2C8

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SIDT2-CYP2C8

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:117064679/chr10:96827448)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	CYP2C8 P10632
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, steroid hormones and vitamins (PubMed:7574697, PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:7574697, PubMed:11093772, PubMed:14559847, PubMed:15766564, PubMed:19965576). Primarily catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) with a preference for the last double bond (PubMed:7574697, PubMed:15766564, PubMed:19965576). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes all trans-retinoic acid toward its 4-hydroxylated form (PubMed:11093772). Displays 16-alpha hydroxylase activity toward estrogen steroid hormones, 17beta-estradiol (E2) and estrone (E1) (PubMed:14559847). Plays a role in the oxidative metabolism of xenobiotics. It is the principal enzyme responsible for the metabolism of the anti-cancer drug paclitaxel (taxol) (PubMed:26427316). {ECO:0000269\|PubMed:11093772, ECO:0000269\|PubMed:14559847, ECO:0000269\|PubMed:15766564, ECO:0000269\|PubMed:19965576, ECO:0000269\|PubMed:26427316, ECO:0000269\|PubMed:7574697}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

764_767

774

833.0

Compositional bias

Note=Poly-Phe

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

19_296

774

833.0

Topological domain

Extracellular

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

318_447

774

833.0

Topological domain

Cytoplasmic

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

469_499

774

833.0

Topological domain

Extracellular

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

521_546

774

833.0

Topological domain

Cytoplasmic

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

568_605

774

833.0

Topological domain

Extracellular

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

627_631

774

833.0

Topological domain

Cytoplasmic

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

653_688

774

833.0

Topological domain

Extracellular

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

710_715

774

833.0

Topological domain

Cytoplasmic

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

737_746

774

833.0

Topological domain

Extracellular

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

297_317

774

833.0

Transmembrane

Helical

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

448_468

774

833.0

Transmembrane

Helical

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

500_520

774

833.0

Transmembrane

Helical

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

547_567

774

833.0

Transmembrane

Helical

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

606_626

774

833.0

Transmembrane

Helical

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

632_652

774

833.0

Transmembrane

Helical

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

689_709

774

833.0

Transmembrane

Helical

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

716_736

774

833.0

Transmembrane

Helical

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

747_767

774

833.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

768_796

774

833.0

Topological domain

Cytoplasmic

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

818_832

774

833.0

Topological domain

Extracellular

Hgene

SIDT2

chr11:117064679

chr10:96827448

ENST00000324225

797_817

774

833.0

Transmembrane

Helical

Top

Fusion Gene Sequence for SIDT2-CYP2C8

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>81829_81829_1_SIDT2-CYP2C8_SIDT2_chr11_117064679_ENST00000324225_CYP2C8_chr10_96827448_ENST00000371270_length(transcript)=4513nt_BP=2853nt
CTCACTTTTCAGTGTTCGTGCGTCGGGACGGCGCGTCCGCCCGCCCTTAAAGGGCCCGCACCTCGGAAAACTCGCAGCCCAGCACGGCGT
CGGGTAGCTACCACCTATCACGCCCCTCACTCTGCGACTCGCCTTCCTCCGCGGCCAGCCCCCGCCGCCGGCTCTTCCTCCCTCCCCTTT
CCCGGCGTCTCCAGGCTCCCGGCAACCAGCCGCCCTCCTTCTCACGGCCCTGGCCCGGGGCTCCAGGGTCTCAGGTCGTACTCAGCCCCT
CGCGAGCTGGGACCCCTTCCCGTAGCCAGCATCCCCTCCCTCCCCGCCCCCTCCCGGCCGCCCCCTCCCCTGCGGGGACCCTGGGAGCCT
CTTCGGGGCTCTTGGGAGGGGACATTTCCTAATCTCAGGCCGGGGTTAAAGTTCTGGTCCTGGTGAGATGCTGGAAGCTGCGGCCGCAGC
CGCAACCCGTCCCGGAGGTGTCCTGTCTCCTGTCGCCGCCGCCGCCGCCACCACCGCTGCCACTGCCGCCCTGCCGGGGCCATGTTCGCT
CTGGGCTTGCCCTTCTTGGTGCTCTTGGTGGCCTCGGTCGAGAGCCATCTGGGGGTTCTGGGGCCCAAGAACGTCTCGCAGAAAGACGCC
GAGTTTGAGCGCACCTACGTGGACGAGGTCAACAGCGAGCTGGTCAACATCTACACCTTCAACCATACTGTGACCCGCAACAGGACAGAG
GGCGTGCGTGTGTCTGTGAACGTCCTGAACAAGCAGAAGGGGGCGCCGTTGCTGTTTGTGGTCCGCCAGAAGGAGGCTGTGGTGTCCTTC
CAGGTGCCCCTAATCCTGCGAGGGATGTTTCAGCGCAAGTACCTCTACCAAAAAGTGGAACGAACCCTGTGTCAGCCCCCCACCAAGAAT
GAGTCGGAGATTCAGTTCTTCTACGTGGATGTGTCCACCCTGTCACCAGTCAACACCACATACCAGCTCCGGGTCAGCCGCATGGACGAT
TTTGTGCTCAGGACTGGGGAGCAGTTCAGCTTCAATACCACAGCAGCACAGCCCCAGTACTTCAAGTATGAGTTCCCTGAAGGCGTGGAC
TCGGTAATTGTCAAGGTGACCTCCAACAAGGCCTTCCCCTGCTCAGTCATCTCCATTCAGGATGTGCTGTGTCCTGTCTATGACCTGGAC
AACAACGTAGCCTTCATCGGCATGTACCAGACGATGACCAAGAAGGCGGCCATCACCGTACAGCGCAAAGACTTCCCCAGCAACAGCTTT
TATGTGGTGGTGGTGGTGAAGACCGAAGACCAAGCCTGCGGGGGCTCCCTGCCTTTCTACCCCTTCGCAGAAGATGAACCGGTCGATCAA
GGGCACCGCCAGAAAACCCTGTCAGTGCTGGTGTCTCAAGCAGTCACGTCTGAGGCATACGTCAGTGGGATGCTCTTTTGCCTGGGTATA
TTTCTCTCCTTTTACCTGCTGACCGTCCTCCTGGCCTGCTGGGAGAACTGGAGGCAGAAGAAGAAGACCCTGCTGGTGGCCATTGACCGA
GCCTGCCCAGAAAGCGGTCACCCTCGAGTCCTGGCTGATTCTTTTCCTGGCAGTTCCCCTTATGAGGGTTACAACTATGGCTCCTTTGAG
AATGTTTCTGGATCTACCGATGGTCTGGTTGACAGCGCTGGCACTGGGGACCTCTCTTACGGTTACCAGGGCCGCTCCTTTGAACCTGTA
GGTACTCGGCCCCGAGTGGACTCCATGAGCTCTGTGGAGGAGGATGACTACGACACATTGACCGACATCGATTCCGACAAGAATGTCATT
CGCACCAAGCAATACCTCTATGTGGCTGACCTGGCACGGAAGGACAAGCGTGTTCTGCGGAAAAAGTACCAGATCTACTTCTGGAACATT
GCCACCATTGCTGTCTTCTATGCCCTTCCTGTGGTGCAGCTGGTGATCACCTACCAGACGGTGGTGAATGTCACAGGGAATCAGGACATC
TGCTACTACAACTTCCTCTGCGCCCACCCACTGGGCAATCTCAGCGCCTTCAACAACATCCTCAGCAACCTGGGGTACATCCTGCTGGGG
CTGCTTTTCCTGCTCATCATCCTGCAACGGGAGATCAACCACAACCGGGCCCTGCTGCGCAATGACCTCTGTGCCCTGGAATGTGGGATC
CCCAAACACTTTGGGCTTTTCTACGCCATGGGCACAGCCCTGATGATGGAGGGGCTGCTCAGTGCTTGCTATCATGTGTGCCCCAACTAT
ACCAATTTCCAGTTTGACACATCGTTCATGTACATGATCGCCGGACTCTGCATGCTGAAGCTCTACCAGAAGCGGCACCCGGACATCAAC
GCCAGCGCCTACAGTGCCTACGCCTGCCTGGCCATTGTCATCTTCTTCTCTGTGCTGGGCGTGGTCTTTGGCAAAGGGAACACGGCGTTC
TGGATCGTCTTCTCCATCATTCACATCATCGCCACCCTGCTCCTCAGCACGCAGCTCTATTACATGGGCCGGTGGAAACTGGACTCGGGG
ATCTTCCGCCGCATCCTCCACGTGCTCTACACAGACTGCATCCGGCAGTGCAGCGGGCCGCTCTACGTGGACCGCATGGTGCTGCTGGTC
ATGGGCAACGTCATCAACTGGTCGCTGGCTGCCTATGGGCTTATCATGCGCCCCAATGATTTCGCTTCCTACTTGTTGGCCATTGGCATC
TGCAACCTGCTCCTTTACTTCGCCTTCTACATCATCATGAAGCTCCGGAGTGGGGAGAGGATCAAGCTCATCCCCCTGCTCTGCATCGTT
TGCACCTCCGTGGTCTGGGGCTTCGCGCTCTTCTTCTTCTTCCAGGGACTCAGCACCTGGCAGTTCTCAAAAGTCTATGGTCCTGTGTTC
ACCGTGTATTTTGGCATGAATCCCATAGTGGTGTTTCATGGATATGAGGCAGTGAAGGAAGCCCTGATTGATAATGGAGAGGAGTTTTCT
GGAAGAGGCAATTCCCCAATATCTCAAAGAATTACTAAAGGACTTGGAATCATTTCCAGCAATGGAAAGAGATGGAAGGAGATCCGGCGT
TTCTCCCTCACAACCTTGCGGAATTTTGGGATGGGGAAGAGGAGCATTGAGGACCGTGTTCAAGAGGAAGCTCACTGCCTTGTGGAGGAG
TTGAGAAAAACCAAGGCTTCACCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCCGTTGTTTTCCAGAAA
CGATTTGATTATAAAGATCAGAATTTTCTCACCCTGATGAAAAGATTCAATGAAAACTTCAGGATTCTGAACTCCCCATGGATCCAGGTC
TGCAATAATTTCCCTCTACTCATTGATTGTTTCCCAGGAACTCACAACAAAGTGCTTAAAAATGTTGCTCTTACACGAAGTTACATTAGG
GAGAAAGTAAAAGAACACCAAGCATCACTGGATGTTAACAATCCTCGGGACTTTATCGATTGCTTCCTGATCAAAATGGAGCAGGAAAAG
GACAACCAAAAGTCAGAATTCAATATTGAAAACTTGGTTGGCACTGTAGCTGATCTATTTGTTGCTGGAACAGAGACAACAAGCACCACT
CTGAGATATGGACTCCTGCTCCTGCTGAAGCACCCAGAGGTCACAGCTAAAGTCCAGGAAGAGATTGATCATGTAATTGGCAGACACAGG
AGCCCCTGCATGCAGGATAGGAGCCACATGCCTTACACTGATGCTGTAGTGCACGAGATCCAGAGATACAGTGACCTTGTCCCCACCGGT
GTGCCCCATGCAGTGACCACTGATACTAAGTTCAGAAACTACCTCATCCCCAAGGGCACAACCATAATGGCATTACTGACTTCCGTGCTA
CATGATGACAAAGAATTTCCTAATCCAAATATCTTTGACCCTGGCCACTTTCTAGATAAGAATGGCAACTTTAAGAAAAGTGACTACTTC
ATGCCTTTCTCAGCAGGAAAACGAATTTGTGCAGGAGAAGGACTTGCCCGCATGGAGCTATTTTTATTTCTAACCACAATTTTACAGAAC
TTTAACCTGAAATCTGTTGATGATTTAAAGAACCTCAATACTACTGCAGTTACCAAAGGGATTGTTTCTCTGCCACCCTCATACCAGATC
TGCTTCATCCCTGTCTGAAGAATGCTAGCCCATCTGGCTGCCGATCTGCTATCACCTGCAACTCTTTTTTTATCAAGGACATTCCCACTA
TTATGTCTTCTCTGACCTCTCATCAAATCTTCCCATTCACTCAATATCCCATAAGCATCCAAACTCCATTAAGGAGAGTTGTTCAGGTCA
CTGCACAAATATATCTGCAATTATTCATACTCTGTAACACTTGTATTAATTGCTGCATATGCTAATACTTTTCTAATGCTGACTTTTTAA
TATGTTATCACTGTAAAACACAGAAAAGTGATTAATGAATGATAATTTAGATCCATTTCTTTTGTGAATGTGCTAAATAAAAAGTGTTAT

>81829_81829_1_SIDT2-CYP2C8_SIDT2_chr11_117064679_ENST00000324225_CYP2C8_chr10_96827448_ENST00000371270_length(amino acids)=1208AA_BP=762
MFALGLPFLVLLVASVESHLGVLGPKNVSQKDAEFERTYVDEVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAV
VSFQVPLILRGMFQRKYLYQKVERTLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVSRMDDFVLRTGEQFSFNTTAAQPQYFKYEFPE
GVDSVIVKVTSNKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFAEDEP
VDQGHRQKTLSVLVSQAVTSEAYVSGMLFCLGIFLSFYLLTVLLACWENWRQKKKTLLVAIDRACPESGHPRVLADSFPGSSPYEGYNYG
SFENVSGSTDGLVDSAGTGDLSYGYQGRSFEPVGTRPRVDSMSSVEEDDYDTLTDIDSDKNVIRTKQYLYVADLARKDKRVLRKKYQIYF
WNIATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNRALLRNDLCALE
CGIPKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGN
TAFWIVFSIIHIIATLLLSTQLYYMGRWKLDSGIFRRILHVLYTDCIRQCSGPLYVDRMVLLVMGNVINWSLAAYGLIMRPNDFASYLLA
IGICNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGE
EFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVV
FQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKME
QEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLV
PTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTI

--------------------------------------------------------------
>81829_81829_2_SIDT2-CYP2C8_SIDT2_chr11_117064679_ENST00000431081_CYP2C8_chr10_96827448_ENST00000371270_length(transcript)=4043nt_BP=2383nt
CCGGAGGTGTCCTGTCTCCTGTCGCCGCCGCCGCCGCCACCACCGCTGCCACTGCCGCCCTGCCGGGGCCATGTTCGCTCTGGGCTTGCC
CTTCTTGGTGCTCTTGGTGGCCTCGGTCGAGAGCCATCTGGGGGTTCTGGGGCCCAAGAACGTCTCGCAGAAAGACGCCGAGTTTGAGCG
CACCTACGTGGACGAGGTCAACAGCGAGCTGGTCAACATCTACACCTTCAACCATACTGTGACCCGCAACAGGACAGAGGGCGTGCGTGT
GTCTGTGAACGTCCTGAACAAGCAGAAGGGGGCGCCGTTGCTGTTTGTGGTCCGCCAGAAGGAGGCTGTGGTGTCCTTCCAGGTGCCCCT
AATCCTGCGAGGGATGTTTCAGCGCAAGTACCTCTACCAAAAAGTGGAACGAACCCTGTGTCAGCCCCCCACCAAGAATGAGTCGGAGAT
TCAGTTCTTCTACGTGGATGTGTCCACCCTGTCACCAGTCAACACCACATACCAGCTCCGGGTCAGCCGCATGGACGATTTTGTGCTCAG
GACTGGGGAGCAGTTCAGCTTCAATACCACAGCAGCACAGCCCCAGTACTTCAAGTATGAGTTCCCTGAAGGCGTGGACTCGGTAATTGT
CAAGGTGACCTCCAACAAGGCCTTCCCCTGCTCAGTCATCTCCATTCAGGATGTGCTGTGTCCTGTCTATGACCTGGACAACAACGTAGC
CTTCATCGGCATGTACCAGACGATGACCAAGAAGGCGGCCATCACCGTACAGCGCAAAGACTTCCCCAGCAACAGCTTTTATGTGGTGGT
GGTGGTGAAGACCGAAGACCAAGCCTGCGGGGGCTCCCTGCCTTTCTACCCCTTCGCAGAAGATGAACCGGTCGATCAAGGGCACCGCCA
GAAAACCCTGTCAGTGCTGGTGTCTCAAGCAGTCACGTCTGAGGCATACGTCAGTGGGATGCTCTTTTGCCTGGGTATATTTCTCTCCTT
TTACCTGCTGACCGTCCTCCTGGCCTGCTGGGAGAACTGGAGGCAGAAGAAGAAGACCCTGCTGGTGGCCATTGACCGAGCCTGCCCAGA
AAGCGCTTCTCTCCTTGGTCACCCTCGAGTCCTGGCTGATTCTTTTCCTGGCAGTTCCCCTTATGAGGGTTACAACTATGGCTCCTTTGA
GAATGTTTCTGGATCTACCGATGGTCTGGTTGACAGCGCTGGCACTGGGGACCTCTCTTACGGTTACCAGGGTACTCGGCCCCGAGTGGA
CTCCATGAGCTCTGTGGAGGAGGATGACTACGACACATTGACCGACATCGATTCCGACAAGAATGTCATTCGCACCAAGCAATACCTCTA
TGTGGCTGACCTGGCACGGAAGGACAAGCGTGTTCTGCGGAAAAAGTACCAGATCTACTTCTGGAACATTGCCACCATTGCTGTCTTCTA
TGCCCTTCCTGTGGTGCAGCTGGTGATCACCTACCAGACGGTGGTGAATGTCACAGGGAATCAGGACATCTGCTACTACAACTTCCTCTG
CGCCCACCCACTGGGCAATCTCAGCGCCTTCAACAACATCCTCAGCAACCTGGGGTACATCCTGCTGGGGCTGCTTTTCCTGCTCATCAT
CCTGCAACGGGAGATCAACCACAACCGGGCCCTGCTGCGCAATGACCTCTGTGCCCTGGAATGTGGGATCCCCAAACACTTTGGGCTTTT
CTACGCCATGGGCACAGCCCTGATGATGGAGGGGCTGCTCAGTGCTTGCTATCATGTGTGCCCCAACTATACCAATTTCCAGTTTGACAC
ATCGTTCATGTACATGATCGCCGGACTCTGCATGCTGAAGCTCTACCAGAAGCGGCACCCGGACATCAACGCCAGCGCCTACAGTGCCTA
CGCCTGCCTGGCCATTGTCATCTTCTTCTCTGTGCTGGGCGTGGTCTTTGGCAAAGGGAACACGGCGTTCTGGATCGTCTTCTCCATCAT
TCACATCATCGCCACCCTGCTCCTCAGCACGCAGCTCTATTACATGGGCCGGTGGAAACTGGACTCGGGGATCTTCCGCCGCATCCTCCA
CGTGCTCTACACAGACTGCATCCGGCAGTGCAGCGGGCCGCTCTACGTGGACCGCATGGTGCTGCTGGTCATGGGCAACGTCATCAACTG
GTCGCTGGCTGCCTATGGGCTTATCATGCGCCCCAATGATTTCGCTTCCTACTTGTTGGCCATTGGCATCTGCAACCTGCTCCTTTACTT
CGCCTTCTACATCATCATGAAGCTCCGGAGTGGGGAGAGGATCAAGCTCATCCCCCTGCTCTGCATCGTTTGCACCTCCGTGGTCTGGGG
CTTCGCGCTCTTCTTCTTCTTCCAGGGACTCAGCACCTGGCAGTTCTCAAAAGTCTATGGTCCTGTGTTCACCGTGTATTTTGGCATGAA
TCCCATAGTGGTGTTTCATGGATATGAGGCAGTGAAGGAAGCCCTGATTGATAATGGAGAGGAGTTTTCTGGAAGAGGCAATTCCCCAAT
ATCTCAAAGAATTACTAAAGGACTTGGAATCATTTCCAGCAATGGAAAGAGATGGAAGGAGATCCGGCGTTTCTCCCTCACAACCTTGCG
GAATTTTGGGATGGGGAAGAGGAGCATTGAGGACCGTGTTCAAGAGGAAGCTCACTGCCTTGTGGAGGAGTTGAGAAAAACCAAGGCTTC
ACCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCCGTTGTTTTCCAGAAACGATTTGATTATAAAGATCA
GAATTTTCTCACCCTGATGAAAAGATTCAATGAAAACTTCAGGATTCTGAACTCCCCATGGATCCAGGTCTGCAATAATTTCCCTCTACT
CATTGATTGTTTCCCAGGAACTCACAACAAAGTGCTTAAAAATGTTGCTCTTACACGAAGTTACATTAGGGAGAAAGTAAAAGAACACCA
AGCATCACTGGATGTTAACAATCCTCGGGACTTTATCGATTGCTTCCTGATCAAAATGGAGCAGGAAAAGGACAACCAAAAGTCAGAATT
CAATATTGAAAACTTGGTTGGCACTGTAGCTGATCTATTTGTTGCTGGAACAGAGACAACAAGCACCACTCTGAGATATGGACTCCTGCT
CCTGCTGAAGCACCCAGAGGTCACAGCTAAAGTCCAGGAAGAGATTGATCATGTAATTGGCAGACACAGGAGCCCCTGCATGCAGGATAG
GAGCCACATGCCTTACACTGATGCTGTAGTGCACGAGATCCAGAGATACAGTGACCTTGTCCCCACCGGTGTGCCCCATGCAGTGACCAC
TGATACTAAGTTCAGAAACTACCTCATCCCCAAGGGCACAACCATAATGGCATTACTGACTTCCGTGCTACATGATGACAAAGAATTTCC
TAATCCAAATATCTTTGACCCTGGCCACTTTCTAGATAAGAATGGCAACTTTAAGAAAAGTGACTACTTCATGCCTTTCTCAGCAGGAAA
ACGAATTTGTGCAGGAGAAGGACTTGCCCGCATGGAGCTATTTTTATTTCTAACCACAATTTTACAGAACTTTAACCTGAAATCTGTTGA
TGATTTAAAGAACCTCAATACTACTGCAGTTACCAAAGGGATTGTTTCTCTGCCACCCTCATACCAGATCTGCTTCATCCCTGTCTGAAG
AATGCTAGCCCATCTGGCTGCCGATCTGCTATCACCTGCAACTCTTTTTTTATCAAGGACATTCCCACTATTATGTCTTCTCTGACCTCT
CATCAAATCTTCCCATTCACTCAATATCCCATAAGCATCCAAACTCCATTAAGGAGAGTTGTTCAGGTCACTGCACAAATATATCTGCAA
TTATTCATACTCTGTAACACTTGTATTAATTGCTGCATATGCTAATACTTTTCTAATGCTGACTTTTTAATATGTTATCACTGTAAAACA

>81829_81829_2_SIDT2-CYP2C8_SIDT2_chr11_117064679_ENST00000431081_CYP2C8_chr10_96827448_ENST00000371270_length(amino acids)=1205AA_BP=759
MFALGLPFLVLLVASVESHLGVLGPKNVSQKDAEFERTYVDEVNSELVNIYTFNHTVTRNRTEGVRVSVNVLNKQKGAPLLFVVRQKEAV
VSFQVPLILRGMFQRKYLYQKVERTLCQPPTKNESEIQFFYVDVSTLSPVNTTYQLRVSRMDDFVLRTGEQFSFNTTAAQPQYFKYEFPE
GVDSVIVKVTSNKAFPCSVISIQDVLCPVYDLDNNVAFIGMYQTMTKKAAITVQRKDFPSNSFYVVVVVKTEDQACGGSLPFYPFAEDEP
VDQGHRQKTLSVLVSQAVTSEAYVSGMLFCLGIFLSFYLLTVLLACWENWRQKKKTLLVAIDRACPESASLLGHPRVLADSFPGSSPYEG
YNYGSFENVSGSTDGLVDSAGTGDLSYGYQGTRPRVDSMSSVEEDDYDTLTDIDSDKNVIRTKQYLYVADLARKDKRVLRKKYQIYFWNI
ATIAVFYALPVVQLVITYQTVVNVTGNQDICYYNFLCAHPLGNLSAFNNILSNLGYILLGLLFLLIILQREINHNRALLRNDLCALECGI
PKHFGLFYAMGTALMMEGLLSACYHVCPNYTNFQFDTSFMYMIAGLCMLKLYQKRHPDINASAYSAYACLAIVIFFSVLGVVFGKGNTAF
WIVFSIIHIIATLLLSTQLYYMGRWKLDSGIFRRILHVLYTDCIRQCSGPLYVDRMVLLVMGNVINWSLAAYGLIMRPNDFASYLLAIGI
CNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFS
GRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQK
RFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEK
DNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTG
VPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQN

--------------------------------------------------------------
>81829_81829_3_SIDT2-CYP2C8_SIDT2_chr11_117064679_ENST00000532062_CYP2C8_chr10_96827448_ENST00000371270_length(transcript)=2413nt_BP=753nt
CTGCATCCGGCAGTGCAGCGGGCCGCTCTACGTGGTACCTGCCTGGTTCCCCTGCTCCATTCTCCACATCTCCTTTCTTCCCTCTGATGG
GGGAGTGGGGCTGGGCTGAGGACCCAGGGGAGAGTGGGGACCAGCTGGCTGGGCCTTCTTCCACCACCCTCCCTGCCCCTGCCCTCAGTC
CCTGTGTCCCTGCTTCCCTCCAGGACCGCATGGTGCTGCTGGTCATGGGCAACGTCATCAACTGGTCGCTGTGAGTATGGTCAGCAGTAG
TGGCCTGGTTGGGTGGACAGCTGGGGACTCGGTCAGCCACTGGCTGCCTTGGGGGCTAAGGACAACTTCCAAATGTTGGGCATAAGACAT
GGGGGCTAAGAGAGATCTTGGCCTCTCTTCTCTCTCTTGGCATCTGGGCTTCTAGAATCTTCTGTGGGCTTCTGAACACAGCCCAACATC
ATAATAAAACATGCCTAGGCAGGGCAGGAAGAGCACTTCCTTGCCCTTGGGCTTCCTGCTTCACCACCCTTCATCCCTCTTGCCAGGGCT
GCCTATGGGCTTATCATGCGCCCCAATGATTTCGCTTCCTACTTGTTGGCCATTGGCATCTGCAACCTGCTCCTTTACTTCGCCTTCTAC
ATCATCATGAAGCTCCGGAGTGGGGAGAGGATCAAGCTCATCCCCCTGCTCTGCATCGTTTGCACCTCCGTGGTCTGGGGCTTCGCGCTC
TTCTTCTTCTTCCAGGGACTCAGCACCTGGCAGTTCTCAAAAGTCTATGGTCCTGTGTTCACCGTGTATTTTGGCATGAATCCCATAGTG
GTGTTTCATGGATATGAGGCAGTGAAGGAAGCCCTGATTGATAATGGAGAGGAGTTTTCTGGAAGAGGCAATTCCCCAATATCTCAAAGA
ATTACTAAAGGACTTGGAATCATTTCCAGCAATGGAAAGAGATGGAAGGAGATCCGGCGTTTCTCCCTCACAACCTTGCGGAATTTTGGG
ATGGGGAAGAGGAGCATTGAGGACCGTGTTCAAGAGGAAGCTCACTGCCTTGTGGAGGAGTTGAGAAAAACCAAGGCTTCACCCTGTGAT
CCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCCGTTGTTTTCCAGAAACGATTTGATTATAAAGATCAGAATTTTCTC
ACCCTGATGAAAAGATTCAATGAAAACTTCAGGATTCTGAACTCCCCATGGATCCAGGTCTGCAATAATTTCCCTCTACTCATTGATTGT
TTCCCAGGAACTCACAACAAAGTGCTTAAAAATGTTGCTCTTACACGAAGTTACATTAGGGAGAAAGTAAAAGAACACCAAGCATCACTG
GATGTTAACAATCCTCGGGACTTTATCGATTGCTTCCTGATCAAAATGGAGCAGGAAAAGGACAACCAAAAGTCAGAATTCAATATTGAA
AACTTGGTTGGCACTGTAGCTGATCTATTTGTTGCTGGAACAGAGACAACAAGCACCACTCTGAGATATGGACTCCTGCTCCTGCTGAAG
CACCCAGAGGTCACAGCTAAAGTCCAGGAAGAGATTGATCATGTAATTGGCAGACACAGGAGCCCCTGCATGCAGGATAGGAGCCACATG
CCTTACACTGATGCTGTAGTGCACGAGATCCAGAGATACAGTGACCTTGTCCCCACCGGTGTGCCCCATGCAGTGACCACTGATACTAAG
TTCAGAAACTACCTCATCCCCAAGGGCACAACCATAATGGCATTACTGACTTCCGTGCTACATGATGACAAAGAATTTCCTAATCCAAAT
ATCTTTGACCCTGGCCACTTTCTAGATAAGAATGGCAACTTTAAGAAAAGTGACTACTTCATGCCTTTCTCAGCAGGAAAACGAATTTGT
GCAGGAGAAGGACTTGCCCGCATGGAGCTATTTTTATTTCTAACCACAATTTTACAGAACTTTAACCTGAAATCTGTTGATGATTTAAAG
AACCTCAATACTACTGCAGTTACCAAAGGGATTGTTTCTCTGCCACCCTCATACCAGATCTGCTTCATCCCTGTCTGAAGAATGCTAGCC
CATCTGGCTGCCGATCTGCTATCACCTGCAACTCTTTTTTTATCAAGGACATTCCCACTATTATGTCTTCTCTGACCTCTCATCAAATCT
TCCCATTCACTCAATATCCCATAAGCATCCAAACTCCATTAAGGAGAGTTGTTCAGGTCACTGCACAAATATATCTGCAATTATTCATAC
TCTGTAACACTTGTATTAATTGCTGCATATGCTAATACTTTTCTAATGCTGACTTTTTAATATGTTATCACTGTAAAACACAGAAAAGTG

>81829_81829_3_SIDT2-CYP2C8_SIDT2_chr11_117064679_ENST00000532062_CYP2C8_chr10_96827448_ENST00000371270_length(amino acids)=500AA_BP=54
MRPNDFASYLLAIGICNLLLYFAFYIIMKLRSGERIKLIPLLCIVCTSVVWGFALFFFFQGLSTWQFSKVYGPVFTVYFGMNPIVVFHGY
EAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFIL
GCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNP
RDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDA
VVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SIDT2-CYP2C8

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SIDT2-CYP2C8

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SIDT2-CYP2C8

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source