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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SIL1-SLC23A1 (FusionGDB2 ID:81893)

Fusion Gene Summary for SIL1-SLC23A1

Fusion gene summary

Fusion gene information	Fusion gene name: SIL1-SLC23A1
	Fusion gene ID: 81893
		Hgene	Tgene
	Gene symbol	SIL1	SLC23A1
	Gene ID	64374	9963
	Gene name	SIL1 nucleotide exchange factor	solute carrier family 23 member 1
	Synonyms	BAP\|MSS\|ULG5	SLC23A2\|SVCT1\|YSPL3
	Cytomap	5q31.2	5q31.2
	Type of gene	protein-coding	protein-coding
	Description	nucleotide exchange factor SIL1BiP-associated proteinSIL1 homolog, endoplasmic reticulum chaperoneSIL1-like protein endoplasmic reticulum chaperone	solute carrier family 23 member 1Na(+)/L-ascorbic acid transporter 1hSVCT1sodium-dependent vitamin C transporter-1solute carrier family 23 (ascorbic acid transporter), member 1solute carrier family 23 (nucleobase transporters), member 1solute carrie
	Modification date	20200313	20200327
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000265195, ENST00000394817, ENST00000509534, ENST00000515008,	ENST00000503919, ENST00000348729, ENST00000353963,
Fusion gene scores	* DoF score	14 X 11 X 10=1540	4 X 4 X 3=48
	# samples	17	4
	** MAII score	log2(17/1540*10)=-3.17932369944456 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SIL1 [Title/Abstract] AND SLC23A1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SIL1(138456724)-SLC23A1(138716575), # samples:1
Anticipated loss of major functional domain due to fusion event.	SIL1-SLC23A1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. SIL1-SLC23A1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. SIL1-SLC23A1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. SIL1-SLC23A1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SLC23A1	GO:0006814	sodium ion transport	18094143
Tgene	SLC23A1	GO:0009636	response to toxic substance	17575980
Tgene	SLC23A1	GO:0015882	L-ascorbic acid transmembrane transport	10631088\|11895172\|18247577\|18417304\|19216494
Tgene	SLC23A1	GO:0070904	transepithelial L-ascorbic acid transport	18417304

Fusion gene breakpoints across SIL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SLC23A1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCEC	TCGA-2E-A9G8-01A	SIL1	chr5	138456724	-	SLC23A1	chr5	138716575	-

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Fusion Gene ORF analysis for SIL1-SLC23A1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000265195	ENST00000503919	SIL1	chr5	138456724	-	SLC23A1	chr5	138716575	-
5CDS-5UTR	ENST00000394817	ENST00000503919	SIL1	chr5	138456724	-	SLC23A1	chr5	138716575	-
5CDS-5UTR	ENST00000509534	ENST00000503919	SIL1	chr5	138456724	-	SLC23A1	chr5	138716575	-
Frame-shift	ENST00000265195	ENST00000348729	SIL1	chr5	138456724	-	SLC23A1	chr5	138716575	-
Frame-shift	ENST00000265195	ENST00000353963	SIL1	chr5	138456724	-	SLC23A1	chr5	138716575	-
Frame-shift	ENST00000509534	ENST00000348729	SIL1	chr5	138456724	-	SLC23A1	chr5	138716575	-
Frame-shift	ENST00000509534	ENST00000353963	SIL1	chr5	138456724	-	SLC23A1	chr5	138716575	-
In-frame	ENST00000394817	ENST00000348729	SIL1	chr5	138456724	-	SLC23A1	chr5	138716575	-
In-frame	ENST00000394817	ENST00000353963	SIL1	chr5	138456724	-	SLC23A1	chr5	138716575	-
intron-3CDS	ENST00000515008	ENST00000348729	SIL1	chr5	138456724	-	SLC23A1	chr5	138716575	-
intron-3CDS	ENST00000515008	ENST00000353963	SIL1	chr5	138456724	-	SLC23A1	chr5	138716575	-
intron-5UTR	ENST00000515008	ENST00000503919	SIL1	chr5	138456724	-	SLC23A1	chr5	138716575	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000394817	SIL1	chr5	138456724	-	ENST00000353963	SLC23A1	chr5	138716575	-	2340	384	385	1884	499
ENST00000394817	SIL1	chr5	138456724	-	ENST00000348729	SLC23A1	chr5	138716575	-	2328	384	385	1872	495

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000394817	ENST00000353963	SIL1	chr5	138456724	-	SLC23A1	chr5	138716575	-	0.005216655	0.99478334
ENST00000394817	ENST00000348729	SIL1	chr5	138456724	-	SLC23A1	chr5	138716575	-	0.005429373	0.99457055

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Fusion Genomic Features for SIL1-SLC23A1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SIL1-SLC23A1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:138456724/chr5:138716575)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

230_243

102

767.6666666666666

Intramembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

230_243

102

774.3333333333334

Intramembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

103_103

102

767.6666666666666

Topological domain

Cytoplasmic

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

125_159

102

767.6666666666666

Topological domain

Extracellular

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

181_207

102

767.6666666666666

Topological domain

Cytoplasmic

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

226_229

102

767.6666666666666

Topological domain

Extracellular

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

244_250

102

767.6666666666666

Topological domain

Extracellular

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

272_312

102

767.6666666666666

Topological domain

Cytoplasmic

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

334_358

102

767.6666666666666

Topological domain

Extracellular

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

380_402

102

767.6666666666666

Topological domain

Cytoplasmic

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

424_426

102

767.6666666666666

Topological domain

Extracellular

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

448_457

102

767.6666666666666

Topological domain

Cytoplasmic

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

479_490

102

767.6666666666666

Topological domain

Extracellular

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

512_598

102

767.6666666666666

Topological domain

Cytoplasmic

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

103_103

102

774.3333333333334

Topological domain

Cytoplasmic

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

125_159

102

774.3333333333334

Topological domain

Extracellular

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

181_207

102

774.3333333333334

Topological domain

Cytoplasmic

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

226_229

102

774.3333333333334

Topological domain

Extracellular

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

244_250

102

774.3333333333334

Topological domain

Extracellular

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

272_312

102

774.3333333333334

Topological domain

Cytoplasmic

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

334_358

102

774.3333333333334

Topological domain

Extracellular

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

380_402

102

774.3333333333334

Topological domain

Cytoplasmic

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

424_426

102

774.3333333333334

Topological domain

Extracellular

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

448_457

102

774.3333333333334

Topological domain

Cytoplasmic

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

479_490

102

774.3333333333334

Topological domain

Extracellular

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

512_598

102

774.3333333333334

Topological domain

Cytoplasmic

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

104_124

102

767.6666666666666

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

160_180

102

767.6666666666666

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

208_225

102

767.6666666666666

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

251_271

102

767.6666666666666

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

313_333

102

767.6666666666666

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

359_379

102

767.6666666666666

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

403_423

102

767.6666666666666

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

427_447

102

767.6666666666666

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

458_478

102

767.6666666666666

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

491_511

102

767.6666666666666

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

104_124

102

774.3333333333334

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

160_180

102

774.3333333333334

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

208_225

102

774.3333333333334

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

251_271

102

774.3333333333334

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

313_333

102

774.3333333333334

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

359_379

102

774.3333333333334

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

403_423

102

774.3333333333334

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

427_447

102

774.3333333333334

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

458_478

102

774.3333333333334

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

491_511

102

774.3333333333334

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

1_52

102

767.6666666666666

Topological domain

Cytoplasmic

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

74_81

102

767.6666666666666

Topological domain

Extracellular

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

1_52

102

774.3333333333334

Topological domain

Cytoplasmic

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

74_81

102

774.3333333333334

Topological domain

Extracellular

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

53_73

102

767.6666666666666

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000348729

82_102

102

767.6666666666666

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

53_73

102

774.3333333333334

Transmembrane

Helical

Tgene

SLC23A1

chr5:138456724

chr5:138716575

ENST00000353963

82_102

102

774.3333333333334

Transmembrane

Helical

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Fusion Gene Sequence for SIL1-SLC23A1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>81893_81893_1_SIL1-SLC23A1_SIL1_chr5_138456724_ENST00000394817_SLC23A1_chr5_138716575_ENST00000348729_length(transcript)=2328nt_BP=384nt
GCGGCGTGACAGCTGCCAGCTCACCGGCTCAGACGGTCGCCGCCGCGTTTGCGCAGGGGGAGCTGGTCGCCGCCGCGGCCGCCTGGAATT
GTGGGAGTTGTGTCTGCCACTCGGCTGCCGGAGGCCGAAGGTCCCTGACTATGGCTCCCCAGAGCCTGCCTTCATCTAGGATGGCTCCTC
TGGGCATGCTGCTTGGGCTGCTGATGGCCGCCTGCTTCACCTTCTGCCTCAGTCATCAGAACCTGAAGGAGTTTGCCCTGACCAACCCAG
AGAAGAGCAGCACCAAAGAAACAGAGAGAAAAGAAACCAAAGCCGAGGAGGAGCTGGATGCCGAAGTCCTGGAGGTGTTCCACCCGACGC
ATGAGTGGCAGGCCCTTCAGCCAGGCTGCCGCTGTTCCAGGCCAGTGCCTTTGCATTTCTGGTTCCAGCCAAAGCCATACTGGCTCTGGA
GAGATGGAAATGCCCCCCGGAAGAGGAGATCTACGGTAACTGGAGTCTGCCCCTGAACACCTCTCATATTTGGCACCCACGGATACGGGA
GGTCCAGGGTGCAATCATGGTGTCCAGCGTGGTGGAGGTGGTGATTGGCCTGCTGGGGCTGCCTGGGGCCCTGCTCAACTACATTGGGCC
TCTCACAGTCACCCCCACTGTCTCCCTCATTGGCCTTTCTGTCTTCCAAGCTGCTGGCGACCGAGCTGGCTCCCACTGGGGCATCTCAGC
TTGCTCCATTCTCCTGATCATCCTCTTCTCCCAGTACCTGCGCAACCTCACCTTCCTGCTGCCTGTCTACCGCTGGGGCAAGGGCCTCAC
TCTCCTCCGCATCCAGATCTTCAAAATGTTTCCTATCATGCTGGCCATCATGACCGTGTGGCTGCTCTGCTATGTCCTGACCTTGACAGA
CGTGCTGCCCACAGACCCAAAAGCCTATGGCTTCCAGGCACGAACCGATGCCCGTGGTGACATCATGGCTATTGCACCCTGGATCCGCAT
CCCCTACCCCTGTCAGTGGGGCCTGCCCACGGTGACTGCGGCTGCTGTCCTGGGAATGTTCAGCGCCACTCTGGCAGGCATCATTGAGTC
CATCGGAGATTACTACGCCTGTGCCCGCCTGGCTGGTGCACCACCCCCTCCAGTACATGCTATCAACAGGGGCATCTTCACCGAAGGCAT
TTGCTGCATCATCGCGGGGCTATTGGGCACGGGCAACGGGTCCACCTCGTCCAGTCCCAACATTGGCGTCCTGGGAATTACCAAGGTGGG
CAGCCGGCGCGTGGTGCAGTATGGTGCGGCTATCATGCTGGTCCTGGGCACCATCGGCAAGTTCACGGCCCTCTTCTCCTCGCTCCCTGA
CCCCATCCTGGGGGGCATGTTCTGCACTCTCTTTGGCATGATTACAGCTGTGGGGCTGTCCAACCTGCAATTTGTGGACATGAACTCCTC
TCGCAACCTCTTCGTGCTGGGATTTTCCATGTTCTTCGGGCTCACGCTGCCCAATTACCTGGAGTCCAACCCTGGCGCCATCAATACAGG
CATTCTTGAAGTGGATCAGATTCTGATTGTGCTGCTGACCACGGAGATGTTTGTGGGCGGGTGCCTTGCTTTCATACTTGACAACACAGT
GCCAGGGAGCCCAGAGGAGCGTGGTCTGATACAGTGGAAAGCTGGGGCTCATGCCAACAGTGACATGTCTTCCAGCCTCAAGAGCTACGA
TTTCCCCATTGGGATGGGCATAGTAAAAAGAATTACCTTTCTGAAATACATTCCTATCTGCCCAGTCTTCAAAGGATTTTCTTCAAGTTC
AAAAGATCAGATTGCAATTCCAGAAGACACTCCAGAAAATACAGAAACTGCATCTGTGTGCACCAAGGTCTGAAAAATGACTTCCAGGAA
AGGAAGCATGGTATATAACAGGAAAAGAAAACTACATGGGGAACCAGAAGACCTAAGCCTGAAATCCCAGCCCTGCCCCTAACTAACTTC
TGTGTAAACTCAGATAAGTCACCTTTCTCTGGGATTCAAATTTTTGCATCAGTTAAAAAAAAAGGGGTGGGGGGGAATGGGCCAAAGTCT
GAGTCTTAGAGACTTGTACCAATGTTATGCTATGTCTCTAAATCTTTACTCTCCTAAGTAGACTTGTCAGCATCTAGGAAGAACAGCTAG
AAATTTTCCTCTGTGATATTTTAGACTGCAAGTTGAAAAAAATAAAAAGAAATGAGGGCAGGTTCCAGGGCCTGAAATGTAGGTATGCTG

>81893_81893_1_SIL1-SLC23A1_SIL1_chr5_138456724_ENST00000394817_SLC23A1_chr5_138716575_ENST00000348729_length(amino acids)=495AA_BP=1
MPLFQASAFAFLVPAKAILALERWKCPPEEEIYGNWSLPLNTSHIWHPRIREVQGAIMVSSVVEVVIGLLGLPGALLNYIGPLTVTPTVS
LIGLSVFQAAGDRAGSHWGISACSILLIILFSQYLRNLTFLLPVYRWGKGLTLLRIQIFKMFPIMLAIMTVWLLCYVLTLTDVLPTDPKA
YGFQARTDARGDIMAIAPWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGICCIIAGLL
GTGNGSTSSSPNIGVLGITKVGSRRVVQYGAAIMLVLGTIGKFTALFSSLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLFVLGF
SMFFGLTLPNYLESNPGAINTGILEVDQILIVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSDMSSSLKSYDFPIGMGIV

--------------------------------------------------------------
>81893_81893_2_SIL1-SLC23A1_SIL1_chr5_138456724_ENST00000394817_SLC23A1_chr5_138716575_ENST00000353963_length(transcript)=2340nt_BP=384nt
GCGGCGTGACAGCTGCCAGCTCACCGGCTCAGACGGTCGCCGCCGCGTTTGCGCAGGGGGAGCTGGTCGCCGCCGCGGCCGCCTGGAATT
GTGGGAGTTGTGTCTGCCACTCGGCTGCCGGAGGCCGAAGGTCCCTGACTATGGCTCCCCAGAGCCTGCCTTCATCTAGGATGGCTCCTC
TGGGCATGCTGCTTGGGCTGCTGATGGCCGCCTGCTTCACCTTCTGCCTCAGTCATCAGAACCTGAAGGAGTTTGCCCTGACCAACCCAG
AGAAGAGCAGCACCAAAGAAACAGAGAGAAAAGAAACCAAAGCCGAGGAGGAGCTGGATGCCGAAGTCCTGGAGGTGTTCCACCCGACGC
ATGAGTGGCAGGCCCTTCAGCCAGGCTGCCGCTGTTCCAGGCCAGTGCCTTTGCATTTCTGGTTCCAGCCAAAGCCATACTGGCTCTGGA
GAGATGGAAATGCCCCCCGGAAGAGGAGATCTACGGTAACTGGAGTCTGCCCCTGAACACCTCTCATATTTGGCACCCACGGATACGGGA
GGTGGGTTTGCATGTCCAGGGTGCAATCATGGTGTCCAGCGTGGTGGAGGTGGTGATTGGCCTGCTGGGGCTGCCTGGGGCCCTGCTCAA
CTACATTGGGCCTCTCACAGTCACCCCCACTGTCTCCCTCATTGGCCTTTCTGTCTTCCAAGCTGCTGGCGACCGAGCTGGCTCCCACTG
GGGCATCTCAGCTTGCTCCATTCTCCTGATCATCCTCTTCTCCCAGTACCTGCGCAACCTCACCTTCCTGCTGCCTGTCTACCGCTGGGG
CAAGGGCCTCACTCTCCTCCGCATCCAGATCTTCAAAATGTTTCCTATCATGCTGGCCATCATGACCGTGTGGCTGCTCTGCTATGTCCT
GACCTTGACAGACGTGCTGCCCACAGACCCAAAAGCCTATGGCTTCCAGGCACGAACCGATGCCCGTGGTGACATCATGGCTATTGCACC
CTGGATCCGCATCCCCTACCCCTGTCAGTGGGGCCTGCCCACGGTGACTGCGGCTGCTGTCCTGGGAATGTTCAGCGCCACTCTGGCAGG
CATCATTGAGTCCATCGGAGATTACTACGCCTGTGCCCGCCTGGCTGGTGCACCACCCCCTCCAGTACATGCTATCAACAGGGGCATCTT
CACCGAAGGCATTTGCTGCATCATCGCGGGGCTATTGGGCACGGGCAACGGGTCCACCTCGTCCAGTCCCAACATTGGCGTCCTGGGAAT
TACCAAGGTGGGCAGCCGGCGCGTGGTGCAGTATGGTGCGGCTATCATGCTGGTCCTGGGCACCATCGGCAAGTTCACGGCCCTCTTCTC
CTCGCTCCCTGACCCCATCCTGGGGGGCATGTTCTGCACTCTCTTTGGCATGATTACAGCTGTGGGGCTGTCCAACCTGCAATTTGTGGA
CATGAACTCCTCTCGCAACCTCTTCGTGCTGGGATTTTCCATGTTCTTCGGGCTCACGCTGCCCAATTACCTGGAGTCCAACCCTGGCGC
CATCAATACAGGCATTCTTGAAGTGGATCAGATTCTGATTGTGCTGCTGACCACGGAGATGTTTGTGGGCGGGTGCCTTGCTTTCATACT
TGACAACACAGTGCCAGGGAGCCCAGAGGAGCGTGGTCTGATACAGTGGAAAGCTGGGGCTCATGCCAACAGTGACATGTCTTCCAGCCT
CAAGAGCTACGATTTCCCCATTGGGATGGGCATAGTAAAAAGAATTACCTTTCTGAAATACATTCCTATCTGCCCAGTCTTCAAAGGATT
TTCTTCAAGTTCAAAAGATCAGATTGCAATTCCAGAAGACACTCCAGAAAATACAGAAACTGCATCTGTGTGCACCAAGGTCTGAAAAAT
GACTTCCAGGAAAGGAAGCATGGTATATAACAGGAAAAGAAAACTACATGGGGAACCAGAAGACCTAAGCCTGAAATCCCAGCCCTGCCC
CTAACTAACTTCTGTGTAAACTCAGATAAGTCACCTTTCTCTGGGATTCAAATTTTTGCATCAGTTAAAAAAAAAGGGGTGGGGGGGAAT
GGGCCAAAGTCTGAGTCTTAGAGACTTGTACCAATGTTATGCTATGTCTCTAAATCTTTACTCTCCTAAGTAGACTTGTCAGCATCTAGG
AAGAACAGCTAGAAATTTTCCTCTGTGATATTTTAGACTGCAAGTTGAAAAAAATAAAAAGAAATGAGGGCAGGTTCCAGGGCCTGAAAT
GTAGGTATGCTGCAAGGCTTTTACATTGAATTTGACCCTACATCACTTCAAGACTAATGCATAATATTAAACATCATGTTGAAGAAATAA

>81893_81893_2_SIL1-SLC23A1_SIL1_chr5_138456724_ENST00000394817_SLC23A1_chr5_138716575_ENST00000353963_length(amino acids)=499AA_BP=1
MPLFQASAFAFLVPAKAILALERWKCPPEEEIYGNWSLPLNTSHIWHPRIREVGLHVQGAIMVSSVVEVVIGLLGLPGALLNYIGPLTVT
PTVSLIGLSVFQAAGDRAGSHWGISACSILLIILFSQYLRNLTFLLPVYRWGKGLTLLRIQIFKMFPIMLAIMTVWLLCYVLTLTDVLPT
DPKAYGFQARTDARGDIMAIAPWIRIPYPCQWGLPTVTAAAVLGMFSATLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGICCII
AGLLGTGNGSTSSSPNIGVLGITKVGSRRVVQYGAAIMLVLGTIGKFTALFSSLPDPILGGMFCTLFGMITAVGLSNLQFVDMNSSRNLF
VLGFSMFFGLTLPNYLESNPGAINTGILEVDQILIVLLTTEMFVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSDMSSSLKSYDFPIG

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SIL1-SLC23A1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	SIL1	chr5:138456724	chr5:138716575	ENST00000265195	-	4	11	1_256	81.33333333333333	462.0	HSPA5 and localization to the endoplasmic reticulum
Hgene	SIL1	chr5:138456724	chr5:138716575	ENST00000394817	-	3	10	1_256	81.33333333333333	462.0	HSPA5 and localization to the endoplasmic reticulum

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SIL1-SLC23A1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SIL1-SLC23A1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source