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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SIL1-STK10 (FusionGDB2 ID:81895)

Fusion Gene Summary for SIL1-STK10

Fusion gene summary

Fusion gene information	Fusion gene name: SIL1-STK10
	Fusion gene ID: 81895
		Hgene	Tgene
	Gene symbol	SIL1	STK10
	Gene ID	64374	6793
	Gene name	SIL1 nucleotide exchange factor	serine/threonine kinase 10
	Synonyms	BAP\|MSS\|ULG5	LOK\|PRO2729
	Cytomap	5q31.2	5q35.1
	Type of gene	protein-coding	protein-coding
	Description	nucleotide exchange factor SIL1BiP-associated proteinSIL1 homolog, endoplasmic reticulum chaperoneSIL1-like protein endoplasmic reticulum chaperone	serine/threonine-protein kinase 10lymphocyte-oriented kinase
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000265195, ENST00000394817, ENST00000509534, ENST00000515008,	ENST00000517775, ENST00000176763,
Fusion gene scores	* DoF score	14 X 11 X 10=1540	16 X 15 X 7=1680
	# samples	17	17
	** MAII score	log2(17/1540*10)=-3.17932369944456 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/1680*10)=-3.30485458152842 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SIL1 [Title/Abstract] AND STK10 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SIL1(138456724)-STK10(171583792), # samples:1
Anticipated loss of major functional domain due to fusion event.	SIL1-STK10 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. SIL1-STK10 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. SIL1-STK10 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. SIL1-STK10 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	STK10	GO:0046777	protein autophosphorylation	12639966\|18239682

Fusion gene breakpoints across SIL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across STK10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-B6-A0IE-01A	SIL1	chr5	138456724	-	STK10	chr5	171583792	-

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Fusion Gene ORF analysis for SIL1-STK10

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000265195	ENST00000517775	SIL1	chr5	138456724	-	STK10	chr5	171583792	-
5CDS-intron	ENST00000394817	ENST00000517775	SIL1	chr5	138456724	-	STK10	chr5	171583792	-
5CDS-intron	ENST00000509534	ENST00000517775	SIL1	chr5	138456724	-	STK10	chr5	171583792	-
Frame-shift	ENST00000394817	ENST00000176763	SIL1	chr5	138456724	-	STK10	chr5	171583792	-
In-frame	ENST00000265195	ENST00000176763	SIL1	chr5	138456724	-	STK10	chr5	171583792	-
In-frame	ENST00000509534	ENST00000176763	SIL1	chr5	138456724	-	STK10	chr5	171583792	-
intron-3CDS	ENST00000515008	ENST00000176763	SIL1	chr5	138456724	-	STK10	chr5	171583792	-
intron-intron	ENST00000515008	ENST00000517775	SIL1	chr5	138456724	-	STK10	chr5	171583792	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000265195	SIL1	chr5	138456724	-	ENST00000176763	STK10	chr5	171583792	-	5950	390	333	3140	935
ENST00000509534	SIL1	chr5	138456724	-	ENST00000176763	STK10	chr5	171583792	-	6038	478	421	3228	935

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000265195	ENST00000176763	SIL1	chr5	138456724	-	STK10	chr5	171583792	-	0.004760886	0.99523914
ENST00000509534	ENST00000176763	SIL1	chr5	138456724	-	STK10	chr5	171583792	-	0.004820532	0.99517953

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Fusion Genomic Features for SIL1-STK10

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SIL1-STK10

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:138456724/chr5:171583792)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

STK10

chr5:138456724

chr5:171583792

ENST00000176763

573_947

969.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

STK10

chr5:138456724

chr5:171583792

ENST00000176763

750_884

969.0

Compositional bias

Note=Gln-rich

Tgene

STK10

chr5:138456724

chr5:171583792

ENST00000176763

175_224

969.0

Region

Note=Activation segment

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

STK10

chr5:138456724

chr5:171583792

ENST00000176763

36_294

969.0

Domain

Protein kinase

Tgene

STK10

chr5:138456724

chr5:171583792

ENST00000176763

42_50

969.0

Nucleotide binding

ATP

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Fusion Gene Sequence for SIL1-STK10

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>81895_81895_1_SIL1-STK10_SIL1_chr5_138456724_ENST00000265195_STK10_chr5_171583792_ENST00000176763_length(transcript)=5950nt_BP=390nt
CTGGAATTGTGGGAGTTGTGTCTGCCACTCGGCTGCCGGAGGCCGAAGGCCAGCTATTACTTCTCTACTGAGGCCAACTGTGAGCCCTGG
TGTGTTTCATTGGCAGGAGAAGAGGCTAATTAAGTGAAACTGAAAGGTCCCTGACTATGGCTCCCCAGAGCCTGCCTTCATCTAGGATGG
CTCCTCTGGGCATGCTGCTTGGGCTGCTGATGGCCGCCTGCTTCACCTTCTGCCTCAGTCATCAGAACCTGAAGGAGTTTGCCCTGACCA
ACCCAGAGAAGAGCAGCACCAAAGAAACAGAGAGAAAAGAAACCAAAGCCGAGGAGGAGCTGGATGCCGAAGTCCTGGAGGTGTTCCACC
CGACGCATGAGTGGCAGGCCCTTCAGCCAGGCCAAGAATAAGGAGACGGGTGCTTTGGCTGCGGCCAAAGTCATTGAAACCAAGAGTGAG
GAGGAGCTGGAGGACTACATCGTGGAGATTGAGATCCTGGCCACCTGCGACCACCCCTACATTGTGAAGCTCCTGGGAGCCTACTATCAC
GACGGGAAGCTGTGGATCATGATTGAGTTCTGTCCAGGGGGAGCCGTGGACGCCATCATGCTGGAGCTGGACAGAGGCCTCACGGAGCCC
CAGATACAGGTGGTTTGCCGCCAGATGCTAGAAGCCCTCAACTTCCTGCACAGCAAGAGGATCATCCACCGAGATCTGAAAGCTGGCAAC
GTGCTGATGACCCTCGAGGGAGACATCAGGCTGGCTGACTTTGGTGTGTCTGCCAAGAATCTGAAGACTCTACAGAAACGAGATTCCTTC
ATCGGCACGCCTTACTGGATGGCCCCCGAGGTGGTCATGTGTGAGACCATGAAAGACACGCCCTACGACTACAAAGCCGACATCTGGTCC
CTGGGCATCACGCTGATTGAGATGGCCCAGATCGAGCCGCCACACCACGAGCTCAACCCCATGCGGGTCCTGCTAAAGATCGCCAAGTCG
GACCCTCCCACGCTGCTCACGCCCTCTAAGTGGTCTGTAGAGTTCCGTGACTTCCTGAAGATAGCCCTGGATAAGAACCCAGAAACCCGA
CCCAGTGCCGCGCAGCTGCTGGAGCATCCCTTCGTCAGCAGCATCACCAGTAACAAGGCTCTGCGGGAGCTGGTGGCTGAGGCCAAGGCC
GAGGTGATGGAAGAGATCGAAGACGGCCGGGATGAGGGGGAAGAGGAGGACGCCGTGGATGCCGCCTCCACCCTGGAGAACCATACTCAG
AACTCCTCTGAGGTGAGTCCGCCAAGCCTCAATGCTGACAAGCCTCTCGAGGAGTCACCTTCCACCCCGCTGGCACCCAGCCAGTCTCAG
GACAGTGTGAATGAGCCCTGCAGCCAGCCCTCTGGGGACAGATCCCTCCAAACCACCAGTCCCCCAGTCGTGGCCCCTGGAAATGAGAAC
GGCCTGGCAGTGCCTGTGCCCCTGCGGAAGTCCCGACCCGTGTCAATGGATGCCAGAATTCAGGTAGCCCAGGAGAAGCAAGTTGCTGAG
CAGGGTGGGGACCTCAGCCCAGCAGCCAACAGATCTCAAAAGGCCAGCCAGAGCCGGCCCAACAGCAGCGCCCTGGAGACCTTGGGTGGG
GAGAAGCTGGCCAATGGCAGCCTGGAGCCACCTGCCCAGGCAGCTCCAGGGCCTTCCAAGAGGGACTCGGACTGCAGCAGCCTCTGCACC
TCTGAGAGCATGGACTATGGTACCAATCTCTCCACTGACCTGTCGCTGAACAAAGAGATGGGCTCTCTGTCCATCAAGGACCCGAAACTG
TACAAAAAAACCCTCAAGCGGACACGCAAATTTGTGGTGGATGGTGTGGAGGTGAGCATCACCACCTCCAAGATCATCAGCGAAGATGAG
AAGAAGGATGAGGAGATGAGATTTCTCAGGCGCCAGGAACTCCGAGAGCTTCGGCTGCTCCAGAAAGAAGAGCATCGGAACCAGACCCAG
CTGAGTAACAAGCATGAGCTGCAGCTGGAGCAAATGCATAAACGTTTTGAACAGGAAATCAACGCCAAGAAGAAGTTCTTTGACACGGAA
TTAGAGAACCTGGAGCGTCAGCAAAAGCAGCAAGTGGAGAAGATGGAGCAAGACCATGCCGTGCGCCGCCGGGAGGAGGCCAGGCGGATC
CGCCTGGAGCAGGATCGGGACTACACCAGGTTCCAAGAGCAGCTCAAACTGATGAAGAAAGAGGTGAAGAACGAGGTGGAGAAGCTCCCC
CGACAGCAGCGGAAGGAAAGCATGAAGCAGAAGATGGAGGAGCACACGCAGAAAAAGCAGCTTCTTGACCGGGACTTTGTAGCCAAGCAG
AAGGAGGACCTGGAGCTGGCCATGAAGAGGCTCACCACCGACAACAGGCGGGAGATCTGTGACAAGGAGCGCGAGTGCCTCATGAAGAAG
CAGGAGCTCCTTCGAGACCGGGAAGCAGCCCTGTGGGAGATGGAAGAGCACCAGCTGCAGGAGAGGCACCAGCTGGTGAAGCAGCAGCTC
AAAGACCAGTACTTCCTCCAGCGGCACGAGCTGCTGCGCAAGCATGAGAAGGAGCGGGAGCAGATGCAGCGCTACAACCAGCGCATGATA
GAGCAGCTGAAGGTGCGGCAGCAACAGGAAAAGGCGCGGCTGCCCAAGATCCAGAGGAGTGAGGGCAAGACGCGCATGGCCATGTACAAG
AAGAGCCTCCACATCAACGGCGGGGGCAGCGCAGCTGAGCAGCGTGAGAAGATCAAGCAGTTCTCCCAGCAGGAGGAGAAGAGGCAGAAG
TCGGAGCGGCTGCAGCAACAGCAGAAACACGAGAACCAGATGCGGGACATGCTGGCGCAGTGTGAGAGCAACATGAGCGAGCTGCAGCAG
CTGCAGAATGAAAAGTGCCACCTCCTGGTAGAGCACGAAACCCAGAAACTGAAGGCCCTGGATGAGAGCCATAACCAGAACCTGAAGGAA
TGGCGGGACAAGCTTCGGCCGCGCAAGAAGGCTCTGGAAGAGGATCTGAACCAGAAGAAGCGGGAGCAGGAGATGTTCTTCAAGCTGAGC
GAGGAGGCGGAGTGCCCAAACCCCTCCACCCCAAGCAAGGCCGCCAAGTTCTTCCCCTACAGTTCTGCGGATGCTTCTTAACAACCGCCC
GGGGCTGTGGCTGGCAGCTTGGTGGGCCCCAGGGCCTTCTCCTTCATTCTCTGTGAACATGTAACTCAGGACCCCTTTTCCCTCTTGCGT
CTGTGCCAGCTCAAATCCAGCCCCTCGCCCTGTGCCACCCCAACTGTGCCTGATAGACCTGCCCCAGCGTTCCTGACTTCTTGCTGGCCT
GTGGAGGGTGAGGTGTAATTATTTGTCACCTGAACCTAATGTATATTCTCCTTGAGCCCCAGATCCCTTCAAGCTGGAAGGGATGGGGCT
GTTGGTGGGGTCAGGGTCCAAGAGGAATGGGTGTTCTGTGGCCTCGAGTCCTCTCCTGTTTGCGAAAATACCAGTTTTGCTCTCTGTGGG
ACAAAGCACTGCTGATGAAGTCCCCGTGGGCTCATCCGGGCTGGAATTCTTGGTTTTTCAGCCATTCCCTGCAGAGTCACTCAATCATCA
AGTCCCTCACAGCCATTTCTGTTCCCAGAGGAGCCAGGCCTGCAGCTGGCTGCTCAGGAGATGGCCTCATTCCTCCTGTTCTCCCAGTTT
GCTTTCCACTTAAGACAAAGCCTTGTCTATGTGGGGGGCGGGGACCGGGGAAAGAGGGAGGCTGAAATGTTTATTCTGCTTCTCCCGTGT
TTCATGCCATCTCGCGTCCCCCTTCCTGCACATGGGTGTGAATGCACACACATACGCGTACACACAGGACTTGGTCTGCTGGCCTGGCCT
CTTCTGCCCAGGTGGGTTGGAACACGTTTGCTGCCTGAGCCTGTGCCACTGAGCATGTTAGGTGGAGCAGTTGGTGTGGCACGTGCGGGG
TGTTGGCACCGGAGGCATGGAAAAGCACAGGCTGTACTGCCAGGCTGCGATGCGTGCTGGCCCCCGCACAGGCTCCTGTGTGCAGGGACT
GATTCCTCAGCACACGAGGCTTCCACAACCCAGTCTGCTCCATAGCACTCTGGCCCACCCTGTCTGCAGGTGAAACAGGAGGGCTGTTTG
CCTCTGCCCCATCCCCCCGACTGTGTTCAGGAGTCCCACCTTGCATTTCAGACCTGGGCTGGCAGTCTGTTGGACTTCTCTTCAGGAAGA
AAAAGCATCAGGGGGAAATGGAATGCCCCTGCCCCAGGAACATGGCAGAAGCACAGGTTCTGTACCTCAGATGGACTCCTGCTGGGCCTT
CGGGGTCTCAGTTGGCTTCCCCCAGATTCTGATTCTACAGCTGCAGAATGTATATAACGCAATAAAAGCAAATGTTTGAACCAGTATGCG
GGTTTACTTACAAGGAAACCTTTTTTCACCCTGATTTCTAATTATTTTATTGAAACAACTATAAAATGTATGGTTTCTCCAGGAAGATAT
CTGCTTTTTAAAACAACAAACAAGAACAACAACACAAAACTGGTAATGATTTGGAGTAATCATGCGGGCATATTGAGTCTGGGTAGTGTT
TCGCTGGTGGTAGAGTGGTTGAGACTTCCTGGGAGGACTTTTTCCGCCTTCACTCCTACAGATTTAAGATTCTTTATTTTTAGGCCGGGC
ATGGTGACTCACCTGAGGTGAGGAGTTCGAGACTAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAGTACAAAAATTAGCCAGG
CGTGGTGGTGCATGCCTATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTAAGCCA
AGGTCACACCACTGCACTCCAGCCTAGGTGACAGGGCGAGACTCTGTCTCTCAAAAAAAAAAAAAAAAAAAATTCTTTGAGACAGGGTCT
CTAATATGTTGCCCAAGCTGATCTCAAACTCGTGGCTCAACTGATTCTCCCGCTTCAACCTTGAGTAGCTGGGACGACAGATACATGCTA
CTGCACCCAGCTAGGTTAAGGTTCTGTATACTCTGTCTTTCTAAAGCAATTCCCTGGAAATTTTCTCAACATTGGTTATAACTGAATGCT
TGGGAAGGGAGGGGCAGCCCTTCAACAGGAAAAGGGGACTGCCCAAATCTTAAATGCACAGTCAAGATTCTCTTGGAGCTAGCAATGGTT
CTCAGGTTAGTGAGCATTTAGCTTGCCTGCTGCAGAATTTGACCCAGATGGGGGTGTTTTTTAGGTCTCTCACAAATGAGACAAGCGAAA
CAATTGTCTCCTTTTATTCTCTTTGGTGCATTGGTGCTGGGGAAACATGAACTAGCGGCAGTGTAACTGCAGAACATAGACCCAGTTCTA
CCAGGCCAGGCCAGCGTTGGGAACCACCAGACAGGGCTGCTTTGGGCTTTGCTTACAGTATTTCCATGTGTAGCCTGGCGTGTGAGAAAG
TATTAGGTGAAATGCCAGTTTCATGGTTCAGGTGAAAGTCTGTGATCATTCCCCTCGTGGCTCGTCCTTCACATCACTTTTGCCCTTCAA
GGAGTTGCCGCGTCCCCGCTCAGTGCCGCCTGAGCCCTCAGAGCTCCCCTGTGCTTTTCTGGATGGGGACTGGCGGGGTCACCTAGCCTC
ACCGTGGAGCCACCGTGCAATGCCCATCTCTGAGAGGCCCACGCGGTATTCCTCGTGCCCTGTGTTAGTGCTTTCTGTATAAGGGACAGA
CAGAACTGGGTTTTTTTCCTCTGTCTGGTTTTAGAGTAAATGTAACTAACTTTTATTTTCCCTTTATGAAAGATAGAAATTATTTTTATG
TAGTTTCCAGACTTTATACAAAATTTTTGTAAAATGTTCTCTGGAAAGTTAACTACAAGAATGTAAATATGCTTCTAATAAAATAACAAG

>81895_81895_1_SIL1-STK10_SIL1_chr5_138456724_ENST00000265195_STK10_chr5_171583792_ENST00000176763_length(amino acids)=935AA_BP=18
MPKSWRCSTRRMSGRPFSQAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIML
ELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP
YDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKAL
RELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSP
PVVAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKR
DSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQ
KEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKE
VKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQE
RHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQF
SQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKR

--------------------------------------------------------------
>81895_81895_2_SIL1-STK10_SIL1_chr5_138456724_ENST00000509534_STK10_chr5_171583792_ENST00000176763_length(transcript)=6038nt_BP=478nt
ATTACTTCTCTACTGAGGCCAACTGTGAGCCCTGGTGTGTTTCATTGGCAGGAGAAGAGGCTAATTAAGTGAAACTGAAAGAACAAATAA
AATGATGAGTCCAGTTTCTGTGGCTGATTTCACAGACCCCTCGAGAGACAGCACGGCTATGGAAAGAGCATGGCTTTGGGGCCAAACTGG
CTTTGAATTCTGACTCTACTGCTCTGTGGCTGCATGAACTCTGGCACGTCCCTGACTATGGCTCCCCAGAGCCTGCCTTCATCTAGGATG
GCTCCTCTGGGCATGCTGCTTGGGCTGCTGATGGCCGCCTGCTTCACCTTCTGCCTCAGTCATCAGAACCTGGAGTTTGCCCTGACCAAC
CCAGAGAAGAGCAGCACCAAAGAAACAGAGAGAAAAGAAACCAAAGCCGAGGAGGAGCTGGATGCCGAAGTCCTGGAGGTGTTCCACCCG
ACGCATGAGTGGCAGGCCCTTCAGCCAGGCCAAGAATAAGGAGACGGGTGCTTTGGCTGCGGCCAAAGTCATTGAAACCAAGAGTGAGGA
GGAGCTGGAGGACTACATCGTGGAGATTGAGATCCTGGCCACCTGCGACCACCCCTACATTGTGAAGCTCCTGGGAGCCTACTATCACGA
CGGGAAGCTGTGGATCATGATTGAGTTCTGTCCAGGGGGAGCCGTGGACGCCATCATGCTGGAGCTGGACAGAGGCCTCACGGAGCCCCA
GATACAGGTGGTTTGCCGCCAGATGCTAGAAGCCCTCAACTTCCTGCACAGCAAGAGGATCATCCACCGAGATCTGAAAGCTGGCAACGT
GCTGATGACCCTCGAGGGAGACATCAGGCTGGCTGACTTTGGTGTGTCTGCCAAGAATCTGAAGACTCTACAGAAACGAGATTCCTTCAT
CGGCACGCCTTACTGGATGGCCCCCGAGGTGGTCATGTGTGAGACCATGAAAGACACGCCCTACGACTACAAAGCCGACATCTGGTCCCT
GGGCATCACGCTGATTGAGATGGCCCAGATCGAGCCGCCACACCACGAGCTCAACCCCATGCGGGTCCTGCTAAAGATCGCCAAGTCGGA
CCCTCCCACGCTGCTCACGCCCTCTAAGTGGTCTGTAGAGTTCCGTGACTTCCTGAAGATAGCCCTGGATAAGAACCCAGAAACCCGACC
CAGTGCCGCGCAGCTGCTGGAGCATCCCTTCGTCAGCAGCATCACCAGTAACAAGGCTCTGCGGGAGCTGGTGGCTGAGGCCAAGGCCGA
GGTGATGGAAGAGATCGAAGACGGCCGGGATGAGGGGGAAGAGGAGGACGCCGTGGATGCCGCCTCCACCCTGGAGAACCATACTCAGAA
CTCCTCTGAGGTGAGTCCGCCAAGCCTCAATGCTGACAAGCCTCTCGAGGAGTCACCTTCCACCCCGCTGGCACCCAGCCAGTCTCAGGA
CAGTGTGAATGAGCCCTGCAGCCAGCCCTCTGGGGACAGATCCCTCCAAACCACCAGTCCCCCAGTCGTGGCCCCTGGAAATGAGAACGG
CCTGGCAGTGCCTGTGCCCCTGCGGAAGTCCCGACCCGTGTCAATGGATGCCAGAATTCAGGTAGCCCAGGAGAAGCAAGTTGCTGAGCA
GGGTGGGGACCTCAGCCCAGCAGCCAACAGATCTCAAAAGGCCAGCCAGAGCCGGCCCAACAGCAGCGCCCTGGAGACCTTGGGTGGGGA
GAAGCTGGCCAATGGCAGCCTGGAGCCACCTGCCCAGGCAGCTCCAGGGCCTTCCAAGAGGGACTCGGACTGCAGCAGCCTCTGCACCTC
TGAGAGCATGGACTATGGTACCAATCTCTCCACTGACCTGTCGCTGAACAAAGAGATGGGCTCTCTGTCCATCAAGGACCCGAAACTGTA
CAAAAAAACCCTCAAGCGGACACGCAAATTTGTGGTGGATGGTGTGGAGGTGAGCATCACCACCTCCAAGATCATCAGCGAAGATGAGAA
GAAGGATGAGGAGATGAGATTTCTCAGGCGCCAGGAACTCCGAGAGCTTCGGCTGCTCCAGAAAGAAGAGCATCGGAACCAGACCCAGCT
GAGTAACAAGCATGAGCTGCAGCTGGAGCAAATGCATAAACGTTTTGAACAGGAAATCAACGCCAAGAAGAAGTTCTTTGACACGGAATT
AGAGAACCTGGAGCGTCAGCAAAAGCAGCAAGTGGAGAAGATGGAGCAAGACCATGCCGTGCGCCGCCGGGAGGAGGCCAGGCGGATCCG
CCTGGAGCAGGATCGGGACTACACCAGGTTCCAAGAGCAGCTCAAACTGATGAAGAAAGAGGTGAAGAACGAGGTGGAGAAGCTCCCCCG
ACAGCAGCGGAAGGAAAGCATGAAGCAGAAGATGGAGGAGCACACGCAGAAAAAGCAGCTTCTTGACCGGGACTTTGTAGCCAAGCAGAA
GGAGGACCTGGAGCTGGCCATGAAGAGGCTCACCACCGACAACAGGCGGGAGATCTGTGACAAGGAGCGCGAGTGCCTCATGAAGAAGCA
GGAGCTCCTTCGAGACCGGGAAGCAGCCCTGTGGGAGATGGAAGAGCACCAGCTGCAGGAGAGGCACCAGCTGGTGAAGCAGCAGCTCAA
AGACCAGTACTTCCTCCAGCGGCACGAGCTGCTGCGCAAGCATGAGAAGGAGCGGGAGCAGATGCAGCGCTACAACCAGCGCATGATAGA
GCAGCTGAAGGTGCGGCAGCAACAGGAAAAGGCGCGGCTGCCCAAGATCCAGAGGAGTGAGGGCAAGACGCGCATGGCCATGTACAAGAA
GAGCCTCCACATCAACGGCGGGGGCAGCGCAGCTGAGCAGCGTGAGAAGATCAAGCAGTTCTCCCAGCAGGAGGAGAAGAGGCAGAAGTC
GGAGCGGCTGCAGCAACAGCAGAAACACGAGAACCAGATGCGGGACATGCTGGCGCAGTGTGAGAGCAACATGAGCGAGCTGCAGCAGCT
GCAGAATGAAAAGTGCCACCTCCTGGTAGAGCACGAAACCCAGAAACTGAAGGCCCTGGATGAGAGCCATAACCAGAACCTGAAGGAATG
GCGGGACAAGCTTCGGCCGCGCAAGAAGGCTCTGGAAGAGGATCTGAACCAGAAGAAGCGGGAGCAGGAGATGTTCTTCAAGCTGAGCGA
GGAGGCGGAGTGCCCAAACCCCTCCACCCCAAGCAAGGCCGCCAAGTTCTTCCCCTACAGTTCTGCGGATGCTTCTTAACAACCGCCCGG
GGCTGTGGCTGGCAGCTTGGTGGGCCCCAGGGCCTTCTCCTTCATTCTCTGTGAACATGTAACTCAGGACCCCTTTTCCCTCTTGCGTCT
GTGCCAGCTCAAATCCAGCCCCTCGCCCTGTGCCACCCCAACTGTGCCTGATAGACCTGCCCCAGCGTTCCTGACTTCTTGCTGGCCTGT
GGAGGGTGAGGTGTAATTATTTGTCACCTGAACCTAATGTATATTCTCCTTGAGCCCCAGATCCCTTCAAGCTGGAAGGGATGGGGCTGT
TGGTGGGGTCAGGGTCCAAGAGGAATGGGTGTTCTGTGGCCTCGAGTCCTCTCCTGTTTGCGAAAATACCAGTTTTGCTCTCTGTGGGAC
AAAGCACTGCTGATGAAGTCCCCGTGGGCTCATCCGGGCTGGAATTCTTGGTTTTTCAGCCATTCCCTGCAGAGTCACTCAATCATCAAG
TCCCTCACAGCCATTTCTGTTCCCAGAGGAGCCAGGCCTGCAGCTGGCTGCTCAGGAGATGGCCTCATTCCTCCTGTTCTCCCAGTTTGC
TTTCCACTTAAGACAAAGCCTTGTCTATGTGGGGGGCGGGGACCGGGGAAAGAGGGAGGCTGAAATGTTTATTCTGCTTCTCCCGTGTTT
CATGCCATCTCGCGTCCCCCTTCCTGCACATGGGTGTGAATGCACACACATACGCGTACACACAGGACTTGGTCTGCTGGCCTGGCCTCT
TCTGCCCAGGTGGGTTGGAACACGTTTGCTGCCTGAGCCTGTGCCACTGAGCATGTTAGGTGGAGCAGTTGGTGTGGCACGTGCGGGGTG
TTGGCACCGGAGGCATGGAAAAGCACAGGCTGTACTGCCAGGCTGCGATGCGTGCTGGCCCCCGCACAGGCTCCTGTGTGCAGGGACTGA
TTCCTCAGCACACGAGGCTTCCACAACCCAGTCTGCTCCATAGCACTCTGGCCCACCCTGTCTGCAGGTGAAACAGGAGGGCTGTTTGCC
TCTGCCCCATCCCCCCGACTGTGTTCAGGAGTCCCACCTTGCATTTCAGACCTGGGCTGGCAGTCTGTTGGACTTCTCTTCAGGAAGAAA
AAGCATCAGGGGGAAATGGAATGCCCCTGCCCCAGGAACATGGCAGAAGCACAGGTTCTGTACCTCAGATGGACTCCTGCTGGGCCTTCG
GGGTCTCAGTTGGCTTCCCCCAGATTCTGATTCTACAGCTGCAGAATGTATATAACGCAATAAAAGCAAATGTTTGAACCAGTATGCGGG
TTTACTTACAAGGAAACCTTTTTTCACCCTGATTTCTAATTATTTTATTGAAACAACTATAAAATGTATGGTTTCTCCAGGAAGATATCT
GCTTTTTAAAACAACAAACAAGAACAACAACACAAAACTGGTAATGATTTGGAGTAATCATGCGGGCATATTGAGTCTGGGTAGTGTTTC
GCTGGTGGTAGAGTGGTTGAGACTTCCTGGGAGGACTTTTTCCGCCTTCACTCCTACAGATTTAAGATTCTTTATTTTTAGGCCGGGCAT
GGTGACTCACCTGAGGTGAGGAGTTCGAGACTAGCCTGGCCAACATGGCAAAACCCTGTCTCTACTAAAAGTACAAAAATTAGCCAGGCG
TGGTGGTGCATGCCTATAATCCCAGCTACTCGGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCAGAGGTTGCAGTAAGCCAAG
GTCACACCACTGCACTCCAGCCTAGGTGACAGGGCGAGACTCTGTCTCTCAAAAAAAAAAAAAAAAAAAATTCTTTGAGACAGGGTCTCT
AATATGTTGCCCAAGCTGATCTCAAACTCGTGGCTCAACTGATTCTCCCGCTTCAACCTTGAGTAGCTGGGACGACAGATACATGCTACT
GCACCCAGCTAGGTTAAGGTTCTGTATACTCTGTCTTTCTAAAGCAATTCCCTGGAAATTTTCTCAACATTGGTTATAACTGAATGCTTG
GGAAGGGAGGGGCAGCCCTTCAACAGGAAAAGGGGACTGCCCAAATCTTAAATGCACAGTCAAGATTCTCTTGGAGCTAGCAATGGTTCT
CAGGTTAGTGAGCATTTAGCTTGCCTGCTGCAGAATTTGACCCAGATGGGGGTGTTTTTTAGGTCTCTCACAAATGAGACAAGCGAAACA
ATTGTCTCCTTTTATTCTCTTTGGTGCATTGGTGCTGGGGAAACATGAACTAGCGGCAGTGTAACTGCAGAACATAGACCCAGTTCTACC
AGGCCAGGCCAGCGTTGGGAACCACCAGACAGGGCTGCTTTGGGCTTTGCTTACAGTATTTCCATGTGTAGCCTGGCGTGTGAGAAAGTA
TTAGGTGAAATGCCAGTTTCATGGTTCAGGTGAAAGTCTGTGATCATTCCCCTCGTGGCTCGTCCTTCACATCACTTTTGCCCTTCAAGG
AGTTGCCGCGTCCCCGCTCAGTGCCGCCTGAGCCCTCAGAGCTCCCCTGTGCTTTTCTGGATGGGGACTGGCGGGGTCACCTAGCCTCAC
CGTGGAGCCACCGTGCAATGCCCATCTCTGAGAGGCCCACGCGGTATTCCTCGTGCCCTGTGTTAGTGCTTTCTGTATAAGGGACAGACA
GAACTGGGTTTTTTTCCTCTGTCTGGTTTTAGAGTAAATGTAACTAACTTTTATTTTCCCTTTATGAAAGATAGAAATTATTTTTATGTA
GTTTCCAGACTTTATACAAAATTTTTGTAAAATGTTCTCTGGAAAGTTAACTACAAGAATGTAAATATGCTTCTAATAAAATAACAAGGT

>81895_81895_2_SIL1-STK10_SIL1_chr5_138456724_ENST00000509534_STK10_chr5_171583792_ENST00000176763_length(amino acids)=935AA_BP=18
MPKSWRCSTRRMSGRPFSQAKNKETGALAAAKVIETKSEEELEDYIVEIEILATCDHPYIVKLLGAYYHDGKLWIMIEFCPGGAVDAIML
ELDRGLTEPQIQVVCRQMLEALNFLHSKRIIHRDLKAGNVLMTLEGDIRLADFGVSAKNLKTLQKRDSFIGTPYWMAPEVVMCETMKDTP
YDYKADIWSLGITLIEMAQIEPPHHELNPMRVLLKIAKSDPPTLLTPSKWSVEFRDFLKIALDKNPETRPSAAQLLEHPFVSSITSNKAL
RELVAEAKAEVMEEIEDGRDEGEEEDAVDAASTLENHTQNSSEVSPPSLNADKPLEESPSTPLAPSQSQDSVNEPCSQPSGDRSLQTTSP
PVVAPGNENGLAVPVPLRKSRPVSMDARIQVAQEKQVAEQGGDLSPAANRSQKASQSRPNSSALETLGGEKLANGSLEPPAQAAPGPSKR
DSDCSSLCTSESMDYGTNLSTDLSLNKEMGSLSIKDPKLYKKTLKRTRKFVVDGVEVSITTSKIISEDEKKDEEMRFLRRQELRELRLLQ
KEEHRNQTQLSNKHELQLEQMHKRFEQEINAKKKFFDTELENLERQQKQQVEKMEQDHAVRRREEARRIRLEQDRDYTRFQEQLKLMKKE
VKNEVEKLPRQQRKESMKQKMEEHTQKKQLLDRDFVAKQKEDLELAMKRLTTDNRREICDKERECLMKKQELLRDREAALWEMEEHQLQE
RHQLVKQQLKDQYFLQRHELLRKHEKEREQMQRYNQRMIEQLKVRQQQEKARLPKIQRSEGKTRMAMYKKSLHINGGGSAAEQREKIKQF
SQQEEKRQKSERLQQQQKHENQMRDMLAQCESNMSELQQLQNEKCHLLVEHETQKLKALDESHNQNLKEWRDKLRPRKKALEEDLNQKKR

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Top

Fusion Gene PPI Analysis for SIL1-STK10

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	SIL1	chr5:138456724	chr5:171583792	ENST00000265195	-	4	11	1_256	81.33333333333333	462.0	HSPA5 and localization to the endoplasmic reticulum
Hgene	SIL1	chr5:138456724	chr5:171583792	ENST00000394817	-	3	10	1_256	81.33333333333333	462.0	HSPA5 and localization to the endoplasmic reticulum

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SIL1-STK10

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SIL1-STK10

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source