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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SIN3B-C19orf57 (FusionGDB2 ID:81922)

Fusion Gene Summary for SIN3B-C19orf57

check button Fusion gene summary
Fusion gene informationFusion gene name: SIN3B-C19orf57
Fusion gene ID: 81922
HgeneTgene
Gene symbol

SIN3B

C19orf57

Gene ID

23309

79173

Gene nameSIN3 transcription regulator family member Bchromosome 19 open reading frame 57
Synonyms--
Cytomap

19p13.11

19p13.12

Type of geneprotein-codingprotein-coding
Descriptionpaired amphipathic helix protein Sin3bSIN3 homolog B, transcriptional regulatorSIN3 transcription regulator homolog Bhistone deacetylase complex subunit Sin3btranscriptional corepressor Sin3buncharacterized protein C19orf57pre-T/NK cell associated protein (3B3)
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000248054, ENST00000379803, 
ENST00000596802, ENST00000594235, 
ENST00000595541, 		ENST00000346736, 
ENST00000454313, ENST00000586783, 
ENST00000591586, 
Fusion gene scores* DoF score7 X 7 X 3=1478 X 6 X 4=192
# samples 89
** MAII scorelog2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/192*10)=-1.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SIN3B [Title/Abstract] AND C19orf57 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSIN3B(16952779)-C19orf57(13996868), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SIN3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across C19orf57 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-MJ-A68H-01ASIN3Bchr19

16952779

-C19orf57chr19

13996868

-
ChimerDB4SARCTCGA-MJ-A68H-01ASIN3Bchr19

16952779

+C19orf57chr19

13996868

-


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Fusion Gene ORF analysis for SIN3B-C19orf57

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000248054ENST00000346736SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
In-frameENST00000248054ENST00000454313SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
In-frameENST00000248054ENST00000586783SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
In-frameENST00000248054ENST00000591586SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
In-frameENST00000379803ENST00000346736SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
In-frameENST00000379803ENST00000454313SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
In-frameENST00000379803ENST00000586783SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
In-frameENST00000379803ENST00000591586SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
In-frameENST00000596802ENST00000346736SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
In-frameENST00000596802ENST00000454313SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
In-frameENST00000596802ENST00000586783SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
In-frameENST00000596802ENST00000591586SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
intron-3CDSENST00000594235ENST00000346736SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
intron-3CDSENST00000594235ENST00000454313SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
intron-3CDSENST00000594235ENST00000586783SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
intron-3CDSENST00000594235ENST00000591586SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
intron-3CDSENST00000595541ENST00000346736SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
intron-3CDSENST00000595541ENST00000454313SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
intron-3CDSENST00000595541ENST00000586783SIN3Bchr19

16952779

+C19orf57chr19

13996868

-
intron-3CDSENST00000595541ENST00000591586SIN3Bchr19

16952779

+C19orf57chr19

13996868

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000248054SIN3Bchr1916952779+ENST00000586783C19orf57chr1913996868-138960321941306
ENST00000248054SIN3Bchr1916952779+ENST00000454313C19orf57chr1913996868-138960321941306
ENST00000248054SIN3Bchr1916952779+ENST00000346736C19orf57chr1913996868-129660321848275
ENST00000248054SIN3Bchr1916952779+ENST00000591586C19orf57chr1913996868-135560321941306
ENST00000596802SIN3Bchr1916952779+ENST00000586783C19orf57chr1913996868-138259614934306
ENST00000596802SIN3Bchr1916952779+ENST00000454313C19orf57chr1913996868-138259614934306
ENST00000596802SIN3Bchr1916952779+ENST00000346736C19orf57chr1913996868-128959614841275
ENST00000596802SIN3Bchr1916952779+ENST00000591586C19orf57chr1913996868-134859614934306
ENST00000379803SIN3Bchr1916952779+ENST00000586783C19orf57chr1913996868-138259614934306
ENST00000379803SIN3Bchr1916952779+ENST00000454313C19orf57chr1913996868-138259614934306
ENST00000379803SIN3Bchr1916952779+ENST00000346736C19orf57chr1913996868-128959614841275
ENST00000379803SIN3Bchr1916952779+ENST00000591586C19orf57chr1913996868-134859614934306

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000248054ENST00000586783SIN3Bchr1916952779+C19orf57chr1913996868-0.0128821020.9871179
ENST00000248054ENST00000454313SIN3Bchr1916952779+C19orf57chr1913996868-0.0128821020.9871179
ENST00000248054ENST00000346736SIN3Bchr1916952779+C19orf57chr1913996868-0.0151909050.9848091
ENST00000248054ENST00000591586SIN3Bchr1916952779+C19orf57chr1913996868-0.0134561430.98654383
ENST00000596802ENST00000586783SIN3Bchr1916952779+C19orf57chr1913996868-0.0121308970.9878691
ENST00000596802ENST00000454313SIN3Bchr1916952779+C19orf57chr1913996868-0.0121308970.9878691
ENST00000596802ENST00000346736SIN3Bchr1916952779+C19orf57chr1913996868-0.0138014520.98619854
ENST00000596802ENST00000591586SIN3Bchr1916952779+C19orf57chr1913996868-0.0126773830.9873226
ENST00000379803ENST00000586783SIN3Bchr1916952779+C19orf57chr1913996868-0.0121308970.9878691
ENST00000379803ENST00000454313SIN3Bchr1916952779+C19orf57chr1913996868-0.0121308970.9878691
ENST00000379803ENST00000346736SIN3Bchr1916952779+C19orf57chr1913996868-0.0138014520.98619854
ENST00000379803ENST00000591586SIN3Bchr1916952779+C19orf57chr1913996868-0.0126773830.9873226

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Fusion Genomic Features for SIN3B-C19orf57


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SIN3B-C19orf57


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:16952779/chr19:13996868)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000248054+41937_1071941131.0DomainPAH 1
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000379803+42037_1071941163.0DomainPAH 1
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000596802+4837_107194354.0DomainPAH 1

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000248054+419153_2381941131.0DomainPAH 2
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000248054+419292_3691941131.0DomainPAH 3
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000379803+420153_2381941163.0DomainPAH 2
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000379803+420292_3691941163.0DomainPAH 3
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000596802+48153_238194354.0DomainPAH 2
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000596802+48292_369194354.0DomainPAH 3


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Fusion Gene Sequence for SIN3B-C19orf57


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81922_81922_1_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000248054_C19orf57_chr19_13996868_ENST00000346736_length(transcript)=1296nt_BP=603nt
GGCGCAGCTCCGACTTCGGACATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGC
GCCCGCTGGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATC
CGCTTTGGCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATC
AGACGTGTCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCC
AAGAATGGCAAGTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTCAAGCAGCAG
GTGCCGTATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAA
ACCCGCTTCCTAGACCACCCAGAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAGCTCTTTCCTTCGGGGAACAAGCCGGGC
CCTTGCTGGCCGGGCCCCAGCTCACATGCCAATGGAGACCCTGTTGCAGTGGCCAAGGCCCAGCCGAGCCGGCTGATCATGGGCACCCAC
CGGGACCTGGAAGCTTTCAAGCGCCTTAACTACCGGAAGACAAAGCTGGGAGGCAAAGCCCCCCTGCCTTACCCTTCCAAGGGGCCTGGG
AATATCCCTCGAGGGGACCCACCCTGGAGGGAGTTGTAGGCCACTTTGAGGTCTGTGTTTCCTTTGCCACCCAGCCCCCATGTCCGCAGA
CCTCCTCCAAGATGCTCCAGGGGGTCCTAGTGGACCCTACAAACCTCCCTTCAGTTGCCCGGAAGTTGGTCTTCCATGGACAACACAAAG
GAGGCCGTGAGGTCCTGGCCTCACCTGGCCAGGGTCAAGGTCATTTGCCACCCTTGGCTTCAGGGAGGGAAACTGTGTCTCCCACAGCCC
CAGTGACTTCAAGCGGGCCTGGGCTCCAGGAAGCTGGCCACCTCTGAGCAGGGCCCATCCTGTCCGGATTTGCAAATTTTAGGGTCCTGA
GCCAAGTATGGATGGTTCAGAATTTGTTTCTTTCCTGGAGGAGAAGAGAGCTCCCTTTGTTTTCTTTCTCCCCATTTCCATTTTATTTCT

>81922_81922_1_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000248054_C19orf57_chr19_13996868_ENST00000346736_length(amino acids)=275AA_BP=7
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLF
HEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
EIYRSFLEILHTYQLFPSGNKPGPCWPGPSSHANGDPVAVAKAQPSRLIMGTHRDLEAFKRLNYRKTKLGGKAPLPYPSKGPGNIPRGDP

--------------------------------------------------------------
>81922_81922_2_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000248054_C19orf57_chr19_13996868_ENST00000454313_length(transcript)=1389nt_BP=603nt
GGCGCAGCTCCGACTTCGGACATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGC
GCCCGCTGGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATC
CGCTTTGGCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATC
AGACGTGTCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCC
AAGAATGGCAAGTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTCAAGCAGCAG
GTGCCGTATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAA
ACCCGCTTCCTAGACCACCCAGAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAGCTCTTTCCTTCGGGGAACAAGCCGGGC
CCTTGCTGGCCGGGCCCCAGCTCACATGCCAATGGAGACCCTGTTGCAGTGGCCAAGGCCCAGCCGAGGACCTTCGTGGGGATCCAGGCC
TCTGAGGCCTCCAGGATGGAGGATGCCACCAACGTCGTGCGTGGCCTCATCGTTGAGCTCTCCAACCTGAACCGGCTGATCATGGGCACC
CACCGGGACCTGGAAGCTTTCAAGCGCCTTAACTACCGGAAGACAAAGCTGGGAGGCAAAGCCCCCCTGCCTTACCCTTCCAAGGGGCCT
GGGAATATCCCTCGAGGGGACCCACCCTGGAGGGAGTTGTAGGCCACTTTGAGGTCTGTGTTTCCTTTGCCACCCAGCCCCCATGTCCGC
AGACCTCCTCCAAGATGCTCCAGGGGGTCCTAGTGGACCCTACAAACCTCCCTTCAGTTGCCCGGAAGTTGGTCTTCCATGGACAACACA
AAGGAGGCCGTGAGGTCCTGGCCTCACCTGGCCAGGGTCAAGGTCATTTGCCACCCTTGGCTTCAGGGAGGGAAACTGTGTCTCCCACAG
CCCCAGTGACTTCAAGCGGGCCTGGGCTCCAGGAAGCTGGCCACCTCTGAGCAGGGCCCATCCTGTCCGGATTTGCAAATTTTAGGGTCC
TGAGCCAAGTATGGATGGTTCAGAATTTGTTTCTTTCCTGGAGGAGAAGAGAGCTCCCTTTGTTTTCTTTCTCCCCATTTCCATTTTATT

>81922_81922_2_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000248054_C19orf57_chr19_13996868_ENST00000454313_length(amino acids)=306AA_BP=7
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLF
HEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
EIYRSFLEILHTYQLFPSGNKPGPCWPGPSSHANGDPVAVAKAQPRTFVGIQASEASRMEDATNVVRGLIVELSNLNRLIMGTHRDLEAF

--------------------------------------------------------------
>81922_81922_3_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000248054_C19orf57_chr19_13996868_ENST00000586783_length(transcript)=1389nt_BP=603nt
GGCGCAGCTCCGACTTCGGACATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGC
GCCCGCTGGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATC
CGCTTTGGCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATC
AGACGTGTCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCC
AAGAATGGCAAGTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTCAAGCAGCAG
GTGCCGTATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAA
ACCCGCTTCCTAGACCACCCAGAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAGCTCTTTCCTTCGGGGAACAAGCCGGGC
CCTTGCTGGCCGGGCCCCAGCTCACATGCCAATGGAGACCCTGTTGCAGTGGCCAAGGCCCAGCCGAGGACCTTCGTGGGGATCCAGGCC
TCTGAGGCCTCCAGGATGGAGGATGCCACCAACGTCGTGCGTGGCCTCATCGTTGAGCTCTCCAACCTGAACCGGCTGATCATGGGCACC
CACCGGGACCTGGAAGCTTTCAAGCGCCTTAACTACCGGAAGACAAAGCTGGGAGGCAAAGCCCCCCTGCCTTACCCTTCCAAGGGGCCT
GGGAATATCCCTCGAGGGGACCCACCCTGGAGGGAGTTGTAGGCCACTTTGAGGTCTGTGTTTCCTTTGCCACCCAGCCCCCATGTCCGC
AGACCTCCTCCAAGATGCTCCAGGGGGTCCTAGTGGACCCTACAAACCTCCCTTCAGTTGCCCGGAAGTTGGTCTTCCATGGACAACACA
AAGGAGGCCGTGAGGTCCTGGCCTCACCTGGCCAGGGTCAAGGTCATTTGCCACCCTTGGCTTCAGGGAGGGAAACTGTGTCTCCCACAG
CCCCAGTGACTTCAAGCGGGCCTGGGCTCCAGGAAGCTGGCCACCTCTGAGCAGGGCCCATCCTGTCCGGATTTGCAAATTTTAGGGTCC
TGAGCCAAGTATGGATGGTTCAGAATTTGTTTCTTTCCTGGAGGAGAAGAGAGCTCCCTTTGTTTTCTTTCTCCCCATTTCCATTTTATT

>81922_81922_3_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000248054_C19orf57_chr19_13996868_ENST00000586783_length(amino acids)=306AA_BP=7
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLF
HEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
EIYRSFLEILHTYQLFPSGNKPGPCWPGPSSHANGDPVAVAKAQPRTFVGIQASEASRMEDATNVVRGLIVELSNLNRLIMGTHRDLEAF

--------------------------------------------------------------
>81922_81922_4_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000248054_C19orf57_chr19_13996868_ENST00000591586_length(transcript)=1355nt_BP=603nt
GGCGCAGCTCCGACTTCGGACATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGC
GCCCGCTGGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATC
CGCTTTGGCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATC
AGACGTGTCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCC
AAGAATGGCAAGTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTCAAGCAGCAG
GTGCCGTATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAA
ACCCGCTTCCTAGACCACCCAGAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAGCTCTTTCCTTCGGGGAACAAGCCGGGC
CCTTGCTGGCCGGGCCCCAGCTCACATGCCAATGGAGACCCTGTTGCAGTGGCCAAGGCCCAGCCGAGGACCTTCGTGGGGATCCAGGCC
TCTGAGGCCTCCAGGATGGAGGATGCCACCAACGTCGTGCGTGGCCTCATCGTTGAGCTCTCCAACCTGAACCGGCTGATCATGGGCACC
CACCGGGACCTGGAAGCTTTCAAGCGCCTTAACTACCGGAAGACAAAGCTGGGAGGCAAAGCCCCCCTGCCTTACCCTTCCAAGGGGCCT
GGGAATATCCCTCGAGGGGACCCACCCTGGAGGGAGTTGTAGGCCACTTTGAGGTCTGTGTTTCCTTTGCCACCCAGCCCCCATGTCCGC
AGACCTCCTCCAAGATGCTCCAGGGGGTCCTAGTGGACCCTACAAACCTCCCTTCAGTTGCCCGGAAGTTGGTCTTCCATGGACAACACA
AAGGAGGCCGTGAGGTCCTGGCCTCACCTGGCCAGGGTCAAGGTCATTTGCCACCCTTGGCTTCAGGGAGGGAAACTGTGTCTCCCACAG
CCCCAGTGACTTCAAGCGGGCCTGGGCTCCAGGAAGCTGGCCACCTCTGAGCAGGGCCCATCCTGTCCGGATTTGCAAATTTTAGGGTCC
TGAGCCAAGTATGGATGGTTCAGAATTTGTTTCTTTCCTGGAGGAGAAGAGAGCTCCCTTTGTTTTCTTTCTCCCCATTTCCATTTTATT

>81922_81922_4_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000248054_C19orf57_chr19_13996868_ENST00000591586_length(amino acids)=306AA_BP=7
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLF
HEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
EIYRSFLEILHTYQLFPSGNKPGPCWPGPSSHANGDPVAVAKAQPRTFVGIQASEASRMEDATNVVRGLIVELSNLNRLIMGTHRDLEAF

--------------------------------------------------------------
>81922_81922_5_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000379803_C19orf57_chr19_13996868_ENST00000346736_length(transcript)=1289nt_BP=596nt
CTCCGACTTCGGACATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGCGCCCGCT
GGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATCCGCTTTG
GCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATCAGACGTG
TCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCCAAGAATG
GCAAGTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTCAAGCAGCAGGTGCCGT
ATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAAACCCGCT
TCCTAGACCACCCAGAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAGCTCTTTCCTTCGGGGAACAAGCCGGGCCCTTGCT
GGCCGGGCCCCAGCTCACATGCCAATGGAGACCCTGTTGCAGTGGCCAAGGCCCAGCCGAGCCGGCTGATCATGGGCACCCACCGGGACC
TGGAAGCTTTCAAGCGCCTTAACTACCGGAAGACAAAGCTGGGAGGCAAAGCCCCCCTGCCTTACCCTTCCAAGGGGCCTGGGAATATCC
CTCGAGGGGACCCACCCTGGAGGGAGTTGTAGGCCACTTTGAGGTCTGTGTTTCCTTTGCCACCCAGCCCCCATGTCCGCAGACCTCCTC
CAAGATGCTCCAGGGGGTCCTAGTGGACCCTACAAACCTCCCTTCAGTTGCCCGGAAGTTGGTCTTCCATGGACAACACAAAGGAGGCCG
TGAGGTCCTGGCCTCACCTGGCCAGGGTCAAGGTCATTTGCCACCCTTGGCTTCAGGGAGGGAAACTGTGTCTCCCACAGCCCCAGTGAC
TTCAAGCGGGCCTGGGCTCCAGGAAGCTGGCCACCTCTGAGCAGGGCCCATCCTGTCCGGATTTGCAAATTTTAGGGTCCTGAGCCAAGT
ATGGATGGTTCAGAATTTGTTTCTTTCCTGGAGGAGAAGAGAGCTCCCTTTGTTTTCTTTCTCCCCATTTCCATTTTATTTCTTCTGGGA

>81922_81922_5_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000379803_C19orf57_chr19_13996868_ENST00000346736_length(amino acids)=275AA_BP=7
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLF
HEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
EIYRSFLEILHTYQLFPSGNKPGPCWPGPSSHANGDPVAVAKAQPSRLIMGTHRDLEAFKRLNYRKTKLGGKAPLPYPSKGPGNIPRGDP

--------------------------------------------------------------
>81922_81922_6_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000379803_C19orf57_chr19_13996868_ENST00000454313_length(transcript)=1382nt_BP=596nt
CTCCGACTTCGGACATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGCGCCCGCT
GGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATCCGCTTTG
GCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATCAGACGTG
TCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCCAAGAATG
GCAAGTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTCAAGCAGCAGGTGCCGT
ATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAAACCCGCT
TCCTAGACCACCCAGAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAGCTCTTTCCTTCGGGGAACAAGCCGGGCCCTTGCT
GGCCGGGCCCCAGCTCACATGCCAATGGAGACCCTGTTGCAGTGGCCAAGGCCCAGCCGAGGACCTTCGTGGGGATCCAGGCCTCTGAGG
CCTCCAGGATGGAGGATGCCACCAACGTCGTGCGTGGCCTCATCGTTGAGCTCTCCAACCTGAACCGGCTGATCATGGGCACCCACCGGG
ACCTGGAAGCTTTCAAGCGCCTTAACTACCGGAAGACAAAGCTGGGAGGCAAAGCCCCCCTGCCTTACCCTTCCAAGGGGCCTGGGAATA
TCCCTCGAGGGGACCCACCCTGGAGGGAGTTGTAGGCCACTTTGAGGTCTGTGTTTCCTTTGCCACCCAGCCCCCATGTCCGCAGACCTC
CTCCAAGATGCTCCAGGGGGTCCTAGTGGACCCTACAAACCTCCCTTCAGTTGCCCGGAAGTTGGTCTTCCATGGACAACACAAAGGAGG
CCGTGAGGTCCTGGCCTCACCTGGCCAGGGTCAAGGTCATTTGCCACCCTTGGCTTCAGGGAGGGAAACTGTGTCTCCCACAGCCCCAGT
GACTTCAAGCGGGCCTGGGCTCCAGGAAGCTGGCCACCTCTGAGCAGGGCCCATCCTGTCCGGATTTGCAAATTTTAGGGTCCTGAGCCA
AGTATGGATGGTTCAGAATTTGTTTCTTTCCTGGAGGAGAAGAGAGCTCCCTTTGTTTTCTTTCTCCCCATTTCCATTTTATTTCTTCTG

>81922_81922_6_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000379803_C19orf57_chr19_13996868_ENST00000454313_length(amino acids)=306AA_BP=7
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLF
HEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
EIYRSFLEILHTYQLFPSGNKPGPCWPGPSSHANGDPVAVAKAQPRTFVGIQASEASRMEDATNVVRGLIVELSNLNRLIMGTHRDLEAF

--------------------------------------------------------------
>81922_81922_7_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000379803_C19orf57_chr19_13996868_ENST00000586783_length(transcript)=1382nt_BP=596nt
CTCCGACTTCGGACATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGCGCCCGCT
GGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATCCGCTTTG
GCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATCAGACGTG
TCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCCAAGAATG
GCAAGTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTCAAGCAGCAGGTGCCGT
ATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAAACCCGCT
TCCTAGACCACCCAGAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAGCTCTTTCCTTCGGGGAACAAGCCGGGCCCTTGCT
GGCCGGGCCCCAGCTCACATGCCAATGGAGACCCTGTTGCAGTGGCCAAGGCCCAGCCGAGGACCTTCGTGGGGATCCAGGCCTCTGAGG
CCTCCAGGATGGAGGATGCCACCAACGTCGTGCGTGGCCTCATCGTTGAGCTCTCCAACCTGAACCGGCTGATCATGGGCACCCACCGGG
ACCTGGAAGCTTTCAAGCGCCTTAACTACCGGAAGACAAAGCTGGGAGGCAAAGCCCCCCTGCCTTACCCTTCCAAGGGGCCTGGGAATA
TCCCTCGAGGGGACCCACCCTGGAGGGAGTTGTAGGCCACTTTGAGGTCTGTGTTTCCTTTGCCACCCAGCCCCCATGTCCGCAGACCTC
CTCCAAGATGCTCCAGGGGGTCCTAGTGGACCCTACAAACCTCCCTTCAGTTGCCCGGAAGTTGGTCTTCCATGGACAACACAAAGGAGG
CCGTGAGGTCCTGGCCTCACCTGGCCAGGGTCAAGGTCATTTGCCACCCTTGGCTTCAGGGAGGGAAACTGTGTCTCCCACAGCCCCAGT
GACTTCAAGCGGGCCTGGGCTCCAGGAAGCTGGCCACCTCTGAGCAGGGCCCATCCTGTCCGGATTTGCAAATTTTAGGGTCCTGAGCCA
AGTATGGATGGTTCAGAATTTGTTTCTTTCCTGGAGGAGAAGAGAGCTCCCTTTGTTTTCTTTCTCCCCATTTCCATTTTATTTCTTCTG

>81922_81922_7_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000379803_C19orf57_chr19_13996868_ENST00000586783_length(amino acids)=306AA_BP=7
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLF
HEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
EIYRSFLEILHTYQLFPSGNKPGPCWPGPSSHANGDPVAVAKAQPRTFVGIQASEASRMEDATNVVRGLIVELSNLNRLIMGTHRDLEAF

--------------------------------------------------------------
>81922_81922_8_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000379803_C19orf57_chr19_13996868_ENST00000591586_length(transcript)=1348nt_BP=596nt
CTCCGACTTCGGACATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGCGCCCGCT
GGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATCCGCTTTG
GCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATCAGACGTG
TCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCCAAGAATG
GCAAGTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTCAAGCAGCAGGTGCCGT
ATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAAACCCGCT
TCCTAGACCACCCAGAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAGCTCTTTCCTTCGGGGAACAAGCCGGGCCCTTGCT
GGCCGGGCCCCAGCTCACATGCCAATGGAGACCCTGTTGCAGTGGCCAAGGCCCAGCCGAGGACCTTCGTGGGGATCCAGGCCTCTGAGG
CCTCCAGGATGGAGGATGCCACCAACGTCGTGCGTGGCCTCATCGTTGAGCTCTCCAACCTGAACCGGCTGATCATGGGCACCCACCGGG
ACCTGGAAGCTTTCAAGCGCCTTAACTACCGGAAGACAAAGCTGGGAGGCAAAGCCCCCCTGCCTTACCCTTCCAAGGGGCCTGGGAATA
TCCCTCGAGGGGACCCACCCTGGAGGGAGTTGTAGGCCACTTTGAGGTCTGTGTTTCCTTTGCCACCCAGCCCCCATGTCCGCAGACCTC
CTCCAAGATGCTCCAGGGGGTCCTAGTGGACCCTACAAACCTCCCTTCAGTTGCCCGGAAGTTGGTCTTCCATGGACAACACAAAGGAGG
CCGTGAGGTCCTGGCCTCACCTGGCCAGGGTCAAGGTCATTTGCCACCCTTGGCTTCAGGGAGGGAAACTGTGTCTCCCACAGCCCCAGT
GACTTCAAGCGGGCCTGGGCTCCAGGAAGCTGGCCACCTCTGAGCAGGGCCCATCCTGTCCGGATTTGCAAATTTTAGGGTCCTGAGCCA

>81922_81922_8_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000379803_C19orf57_chr19_13996868_ENST00000591586_length(amino acids)=306AA_BP=7
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLF
HEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
EIYRSFLEILHTYQLFPSGNKPGPCWPGPSSHANGDPVAVAKAQPRTFVGIQASEASRMEDATNVVRGLIVELSNLNRLIMGTHRDLEAF

--------------------------------------------------------------
>81922_81922_9_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000596802_C19orf57_chr19_13996868_ENST00000346736_length(transcript)=1289nt_BP=596nt
CTCCGACTTCGGACATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGCGCCCGCT
GGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATCCGCTTTG
GCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATCAGACGTG
TCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCCAAGAATG
GCAAGTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTCAAGCAGCAGGTGCCGT
ATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAAACCCGCT
TCCTAGACCACCCAGAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAGCTCTTTCCTTCGGGGAACAAGCCGGGCCCTTGCT
GGCCGGGCCCCAGCTCACATGCCAATGGAGACCCTGTTGCAGTGGCCAAGGCCCAGCCGAGCCGGCTGATCATGGGCACCCACCGGGACC
TGGAAGCTTTCAAGCGCCTTAACTACCGGAAGACAAAGCTGGGAGGCAAAGCCCCCCTGCCTTACCCTTCCAAGGGGCCTGGGAATATCC
CTCGAGGGGACCCACCCTGGAGGGAGTTGTAGGCCACTTTGAGGTCTGTGTTTCCTTTGCCACCCAGCCCCCATGTCCGCAGACCTCCTC
CAAGATGCTCCAGGGGGTCCTAGTGGACCCTACAAACCTCCCTTCAGTTGCCCGGAAGTTGGTCTTCCATGGACAACACAAAGGAGGCCG
TGAGGTCCTGGCCTCACCTGGCCAGGGTCAAGGTCATTTGCCACCCTTGGCTTCAGGGAGGGAAACTGTGTCTCCCACAGCCCCAGTGAC
TTCAAGCGGGCCTGGGCTCCAGGAAGCTGGCCACCTCTGAGCAGGGCCCATCCTGTCCGGATTTGCAAATTTTAGGGTCCTGAGCCAAGT
ATGGATGGTTCAGAATTTGTTTCTTTCCTGGAGGAGAAGAGAGCTCCCTTTGTTTTCTTTCTCCCCATTTCCATTTTATTTCTTCTGGGA

>81922_81922_9_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000596802_C19orf57_chr19_13996868_ENST00000346736_length(amino acids)=275AA_BP=7
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLF
HEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
EIYRSFLEILHTYQLFPSGNKPGPCWPGPSSHANGDPVAVAKAQPSRLIMGTHRDLEAFKRLNYRKTKLGGKAPLPYPSKGPGNIPRGDP

--------------------------------------------------------------
>81922_81922_10_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000596802_C19orf57_chr19_13996868_ENST00000454313_length(transcript)=1382nt_BP=596nt
CTCCGACTTCGGACATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGCGCCCGCT
GGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATCCGCTTTG
GCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATCAGACGTG
TCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCCAAGAATG
GCAAGTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTCAAGCAGCAGGTGCCGT
ATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAAACCCGCT
TCCTAGACCACCCAGAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAGCTCTTTCCTTCGGGGAACAAGCCGGGCCCTTGCT
GGCCGGGCCCCAGCTCACATGCCAATGGAGACCCTGTTGCAGTGGCCAAGGCCCAGCCGAGGACCTTCGTGGGGATCCAGGCCTCTGAGG
CCTCCAGGATGGAGGATGCCACCAACGTCGTGCGTGGCCTCATCGTTGAGCTCTCCAACCTGAACCGGCTGATCATGGGCACCCACCGGG
ACCTGGAAGCTTTCAAGCGCCTTAACTACCGGAAGACAAAGCTGGGAGGCAAAGCCCCCCTGCCTTACCCTTCCAAGGGGCCTGGGAATA
TCCCTCGAGGGGACCCACCCTGGAGGGAGTTGTAGGCCACTTTGAGGTCTGTGTTTCCTTTGCCACCCAGCCCCCATGTCCGCAGACCTC
CTCCAAGATGCTCCAGGGGGTCCTAGTGGACCCTACAAACCTCCCTTCAGTTGCCCGGAAGTTGGTCTTCCATGGACAACACAAAGGAGG
CCGTGAGGTCCTGGCCTCACCTGGCCAGGGTCAAGGTCATTTGCCACCCTTGGCTTCAGGGAGGGAAACTGTGTCTCCCACAGCCCCAGT
GACTTCAAGCGGGCCTGGGCTCCAGGAAGCTGGCCACCTCTGAGCAGGGCCCATCCTGTCCGGATTTGCAAATTTTAGGGTCCTGAGCCA
AGTATGGATGGTTCAGAATTTGTTTCTTTCCTGGAGGAGAAGAGAGCTCCCTTTGTTTTCTTTCTCCCCATTTCCATTTTATTTCTTCTG

>81922_81922_10_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000596802_C19orf57_chr19_13996868_ENST00000454313_length(amino acids)=306AA_BP=7
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLF
HEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
EIYRSFLEILHTYQLFPSGNKPGPCWPGPSSHANGDPVAVAKAQPRTFVGIQASEASRMEDATNVVRGLIVELSNLNRLIMGTHRDLEAF

--------------------------------------------------------------
>81922_81922_11_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000596802_C19orf57_chr19_13996868_ENST00000586783_length(transcript)=1382nt_BP=596nt
CTCCGACTTCGGACATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGCGCCCGCT
GGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATCCGCTTTG
GCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATCAGACGTG
TCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCCAAGAATG
GCAAGTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTCAAGCAGCAGGTGCCGT
ATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAAACCCGCT
TCCTAGACCACCCAGAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAGCTCTTTCCTTCGGGGAACAAGCCGGGCCCTTGCT
GGCCGGGCCCCAGCTCACATGCCAATGGAGACCCTGTTGCAGTGGCCAAGGCCCAGCCGAGGACCTTCGTGGGGATCCAGGCCTCTGAGG
CCTCCAGGATGGAGGATGCCACCAACGTCGTGCGTGGCCTCATCGTTGAGCTCTCCAACCTGAACCGGCTGATCATGGGCACCCACCGGG
ACCTGGAAGCTTTCAAGCGCCTTAACTACCGGAAGACAAAGCTGGGAGGCAAAGCCCCCCTGCCTTACCCTTCCAAGGGGCCTGGGAATA
TCCCTCGAGGGGACCCACCCTGGAGGGAGTTGTAGGCCACTTTGAGGTCTGTGTTTCCTTTGCCACCCAGCCCCCATGTCCGCAGACCTC
CTCCAAGATGCTCCAGGGGGTCCTAGTGGACCCTACAAACCTCCCTTCAGTTGCCCGGAAGTTGGTCTTCCATGGACAACACAAAGGAGG
CCGTGAGGTCCTGGCCTCACCTGGCCAGGGTCAAGGTCATTTGCCACCCTTGGCTTCAGGGAGGGAAACTGTGTCTCCCACAGCCCCAGT
GACTTCAAGCGGGCCTGGGCTCCAGGAAGCTGGCCACCTCTGAGCAGGGCCCATCCTGTCCGGATTTGCAAATTTTAGGGTCCTGAGCCA
AGTATGGATGGTTCAGAATTTGTTTCTTTCCTGGAGGAGAAGAGAGCTCCCTTTGTTTTCTTTCTCCCCATTTCCATTTTATTTCTTCTG

>81922_81922_11_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000596802_C19orf57_chr19_13996868_ENST00000586783_length(amino acids)=306AA_BP=7
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLF
HEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
EIYRSFLEILHTYQLFPSGNKPGPCWPGPSSHANGDPVAVAKAQPRTFVGIQASEASRMEDATNVVRGLIVELSNLNRLIMGTHRDLEAF

--------------------------------------------------------------
>81922_81922_12_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000596802_C19orf57_chr19_13996868_ENST00000591586_length(transcript)=1348nt_BP=596nt
CTCCGACTTCGGACATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGCGCCCGCT
GGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATCCGCTTTG
GCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATCAGACGTG
TCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCCAAGAATG
GCAAGTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTCAAGCAGCAGGTGCCGT
ATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAAACCCGCT
TCCTAGACCACCCAGAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAGCTCTTTCCTTCGGGGAACAAGCCGGGCCCTTGCT
GGCCGGGCCCCAGCTCACATGCCAATGGAGACCCTGTTGCAGTGGCCAAGGCCCAGCCGAGGACCTTCGTGGGGATCCAGGCCTCTGAGG
CCTCCAGGATGGAGGATGCCACCAACGTCGTGCGTGGCCTCATCGTTGAGCTCTCCAACCTGAACCGGCTGATCATGGGCACCCACCGGG
ACCTGGAAGCTTTCAAGCGCCTTAACTACCGGAAGACAAAGCTGGGAGGCAAAGCCCCCCTGCCTTACCCTTCCAAGGGGCCTGGGAATA
TCCCTCGAGGGGACCCACCCTGGAGGGAGTTGTAGGCCACTTTGAGGTCTGTGTTTCCTTTGCCACCCAGCCCCCATGTCCGCAGACCTC
CTCCAAGATGCTCCAGGGGGTCCTAGTGGACCCTACAAACCTCCCTTCAGTTGCCCGGAAGTTGGTCTTCCATGGACAACACAAAGGAGG
CCGTGAGGTCCTGGCCTCACCTGGCCAGGGTCAAGGTCATTTGCCACCCTTGGCTTCAGGGAGGGAAACTGTGTCTCCCACAGCCCCAGT
GACTTCAAGCGGGCCTGGGCTCCAGGAAGCTGGCCACCTCTGAGCAGGGCCCATCCTGTCCGGATTTGCAAATTTTAGGGTCCTGAGCCA

>81922_81922_12_SIN3B-C19orf57_SIN3B_chr19_16952779_ENST00000596802_C19orf57_chr19_13996868_ENST00000591586_length(amino acids)=306AA_BP=7
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLF
HEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
EIYRSFLEILHTYQLFPSGNKPGPCWPGPSSHANGDPVAVAKAQPRTFVGIQASEASRMEDATNVVRGLIVELSNLNRLIMGTHRDLEAF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SIN3B-C19orf57


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000248054+41959_105194.01131.0REST
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000379803+42059_105194.01163.0REST
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000596802+4859_105194.0354.0REST


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000248054+4191_308194.01131.0CRY1
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000379803+4201_308194.01163.0CRY1
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000596802+481_308194.0354.0CRY1
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000248054+419284_540194.01131.0NCOR1
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000379803+420284_540194.01163.0NCOR1
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000596802+48284_540194.0354.0NCOR1
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000248054+419392_591194.01131.0SUDS3 and HDAC1
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000379803+420392_591194.01163.0SUDS3 and HDAC1
HgeneSIN3Bchr19:16952779chr19:13996868ENST00000596802+48392_591194.0354.0SUDS3 and HDAC1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SIN3B-C19orf57


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SIN3B-C19orf57


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource