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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SIN3B-TBC1D17 (FusionGDB2 ID:81927)

Fusion Gene Summary for SIN3B-TBC1D17

check button Fusion gene summary
Fusion gene informationFusion gene name: SIN3B-TBC1D17
Fusion gene ID: 81927
HgeneTgene
Gene symbol

SIN3B

TBC1D17

Gene ID

23309

79735

Gene nameSIN3 transcription regulator family member BTBC1 domain family member 17
Synonyms--
Cytomap

19p13.11

19q13.33

Type of geneprotein-codingprotein-coding
Descriptionpaired amphipathic helix protein Sin3bSIN3 homolog B, transcriptional regulatorSIN3 transcription regulator homolog Bhistone deacetylase complex subunit Sin3btranscriptional corepressor Sin3bTBC1 domain family member 17
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000248054, ENST00000379803, 
ENST00000595541, ENST00000594235, 
ENST00000596802, 		ENST00000598789, 
ENST00000221543, ENST00000535102, 
Fusion gene scores* DoF score7 X 7 X 3=1478 X 40 X 11=3520
# samples 832
** MAII scorelog2(8/147*10)=-0.877744249949002
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(32/3520*10)=-3.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SIN3B [Title/Abstract] AND TBC1D17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSIN3B(16987389)-TBC1D17(50383536), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SIN3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TBC1D17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-3B-A9HX-01ASIN3Bchr19

16987389

-TBC1D17chr19

50383536

+
ChimerDB4SARCTCGA-3B-A9HX-01ASIN3Bchr19

16987389

+TBC1D17chr19

50383536

+


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Fusion Gene ORF analysis for SIN3B-TBC1D17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000248054ENST00000598789SIN3Bchr19

16987389

+TBC1D17chr19

50383536

+
5CDS-3UTRENST00000379803ENST00000598789SIN3Bchr19

16987389

+TBC1D17chr19

50383536

+
5CDS-3UTRENST00000595541ENST00000598789SIN3Bchr19

16987389

+TBC1D17chr19

50383536

+
In-frameENST00000248054ENST00000221543SIN3Bchr19

16987389

+TBC1D17chr19

50383536

+
In-frameENST00000248054ENST00000535102SIN3Bchr19

16987389

+TBC1D17chr19

50383536

+
In-frameENST00000379803ENST00000221543SIN3Bchr19

16987389

+TBC1D17chr19

50383536

+
In-frameENST00000379803ENST00000535102SIN3Bchr19

16987389

+TBC1D17chr19

50383536

+
In-frameENST00000595541ENST00000221543SIN3Bchr19

16987389

+TBC1D17chr19

50383536

+
In-frameENST00000595541ENST00000535102SIN3Bchr19

16987389

+TBC1D17chr19

50383536

+
intron-3CDSENST00000594235ENST00000221543SIN3Bchr19

16987389

+TBC1D17chr19

50383536

+
intron-3CDSENST00000594235ENST00000535102SIN3Bchr19

16987389

+TBC1D17chr19

50383536

+
intron-3CDSENST00000596802ENST00000221543SIN3Bchr19

16987389

+TBC1D17chr19

50383536

+
intron-3CDSENST00000596802ENST00000535102SIN3Bchr19

16987389

+TBC1D17chr19

50383536

+
intron-3UTRENST00000594235ENST00000598789SIN3Bchr19

16987389

+TBC1D17chr19

50383536

+
intron-3UTRENST00000596802ENST00000598789SIN3Bchr19

16987389

+TBC1D17chr19

50383536

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000248054SIN3Bchr1916987389+ENST00000221543TBC1D17chr1950383536+475228802146311536
ENST00000248054SIN3Bchr1916987389+ENST00000535102TBC1D17chr1950383536+475128802146311536
ENST00000379803SIN3Bchr1916987389+ENST00000221543TBC1D17chr1950383536+484129691447201568
ENST00000379803SIN3Bchr1916987389+ENST00000535102TBC1D17chr1950383536+484029691447201568
ENST00000595541SIN3Bchr1916987389+ENST00000221543TBC1D17chr1950383536+3871199937037501126
ENST00000595541SIN3Bchr1916987389+ENST00000535102TBC1D17chr1950383536+3870199937037501126

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000248054ENST00000221543SIN3Bchr1916987389+TBC1D17chr1950383536+0.0049664830.9950335
ENST00000248054ENST00000535102SIN3Bchr1916987389+TBC1D17chr1950383536+0.0049557320.99504423
ENST00000379803ENST00000221543SIN3Bchr1916987389+TBC1D17chr1950383536+0.0044521170.9955479
ENST00000379803ENST00000535102SIN3Bchr1916987389+TBC1D17chr1950383536+0.0044418380.99555814
ENST00000595541ENST00000221543SIN3Bchr1916987389+TBC1D17chr1950383536+0.0049872650.9950127
ENST00000595541ENST00000535102SIN3Bchr1916987389+TBC1D17chr1950383536+0.0049687240.99503124

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Fusion Genomic Features for SIN3B-TBC1D17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SIN3Bchr1916987389+TBC1D17chr1950383535+5.50E-070.9999994
SIN3Bchr1916987389+TBC1D17chr1950383535+5.50E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SIN3B-TBC1D17


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:16987389/chr19:50383536)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000248054+1619153_2389531131.0DomainPAH 2
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000248054+1619292_3699531131.0DomainPAH 3
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000248054+161937_1079531131.0DomainPAH 1
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000379803+1720153_2389851163.0DomainPAH 2
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000379803+1720292_3699851163.0DomainPAH 3
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000379803+172037_1079851163.0DomainPAH 1
TgeneTBC1D17chr19:16987389chr19:50383536ENST00000221543217596_63165649.0Compositional biasNote=Pro-rich
TgeneTBC1D17chr19:16987389chr19:50383536ENST00000535102116596_63132616.0Compositional biasNote=Pro-rich
TgeneTBC1D17chr19:16987389chr19:50383536ENST00000221543217310_52065649.0DomainRab-GAP TBC
TgeneTBC1D17chr19:16987389chr19:50383536ENST00000535102116310_52032616.0DomainRab-GAP TBC

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000596802+18153_2380354.0DomainPAH 2
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000596802+18292_3690354.0DomainPAH 3
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000596802+1837_1070354.0DomainPAH 1


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Fusion Gene Sequence for SIN3B-TBC1D17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81927_81927_1_SIN3B-TBC1D17_SIN3B_chr19_16987389_ENST00000248054_TBC1D17_chr19_50383536_ENST00000221543_length(transcript)=4752nt_BP=2880nt
GGCGCAGCTCCGACTTCGGACATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGC
GCCCGCTGGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATC
CGCTTTGGCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATC
AGACGTGTCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCC
AAGAATGGCAAGTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTCAAGCAGCAG
GTGCCGTATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAA
ACCCGCTTCCTAGACCACCCAGAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAGAAGGAGCAGCTGAACACGAGGGGCCGG
CCATTCCGAGGCATGTCTGAAGAGGAGGTGTTCACCGAGGTGGCCAACCTCTTCCGGGGCCAGGAGGACCTGCTCTCAGAGTTTGGACAG
TTCCTGCCCGAAGCCAAGCGGTCTCTGTTCACAGGAAACGGGCCGTGCGAGATGCACAGCGTGCAGAAGAACGAGCACGACAAGACCCCG
GAGCACAGCAGGAAGCGCTCCCGGCCCTCGCTCCTCCGCCCCGTGTCTGCACCCGCCAAGAAAAAAATGAAACTTCGTGGTACCAAAGAC
CTGTCCATCGCTGCAGTGGGGAAGTACGGGACTCTGCAGGAATTTTCTTTCTTTGACAAGGTCCGCCGGGTGCTGAAGAGCCAGGAGGTG
TATGAAAACTTCCTCCGCTGCATCGCACTCTTCAACCAGGAGCTGGTGTCTGGCTCTGAGCTCCTGCAGCTCGTCAGCCCATTTCTGGGG
AAATTTCCAGAACTCTTTGCACAGTTCAAGTCCTTCCTGGGGGTAAAAGAGCTGTCCTTCGCGCCACCCATGAGCGACAGATCCGGGGAC
GGGATAAGCCGGGAAATTGATTATGCATCCTGCAAGCGCATAGGATCCAGCTACCGGGCACTCCCCAAAACCTACCAGCAGCCCAAGTGC
AGTGGGAGGACAGCCATCTGCAAGGAGGTACTGAACGACACCTGGGTCTCCTTCCCTTCCTGGTCTGAGGACTCCACGTTCGTCAGCTCC
AAGAAGACACCGTACGAGGAGCAGCTTCACCGCTGTGAGGACGAGCGCTTCGAGTTAGACGTTGTCCTGGAGACGAACCTGGCCACAATC
CGTGTGTTGGAAAGTGTGCAGAAGAAGCTATCTCGGATGGCGCCGGAAGACCAGGAGAAGTTCCGGCTGGACGACTCCCTGGGAGGCACG
TCGGAGGTGATCCAGCGCCGTGCCATTTATCGCATCTATGGCGACAAGGCCCCGGAGATCATCGAGAGCCTCAAGAAGAACCCTGTCACC
GCTGTCCCCGTTGTCCTGAAAAGACTGAAGGCCAAGGAAGAGGAGTGGCGGGAGGCCCAGCAGGGCTTCAACAAGATCTGGCGGGAGCAG
TATGAGAAGGCGTACCTCAAGTCCCTTGACCACCAGGCTGTGAACTTCAAGCAGAACGACACCAAGGCCCTGCGCTCCAAGAGCTTGCTC
AACGAGATCGAGAGCGTCTACGACGAGCACCAGGAGCAGCACTCGGAGGGCCGCAGTGCCCCCTCTAGCGAGCCGCACCTCATCTTTGTG
TACGAGGACCGGCAGATCCTGGAGGACGCAGCAGCGCTCATCAGCTACTACGTGAAGCGGCAGCCGGCCATCCAGAAGGAGGACCAGGGC
ACCATCCACCAGCTGCTGCACCAGTTCGTGCCCAGCCTCTTCTTCTCTCAGCAGCTGGACCTGGGCGCCTCCGAGGAGTCAGCTGATGAG
GACCGGGACAGCCCCCAGGGGCAGACCACAGACCCCAGTGAGCGGAAGAAGCCGGCGCCAGGACCCCACAGTAGCCCCCCAGAGGAGAAG
GGGGCCTTCGGGGATGCCCCGGCCACTGAGCAGCCACCCCTGCCGCCCCCAGCCCCGCACAAGCCCCTGGACGATGTCTACAGCCTATTT
TTTGCCAACAACAACTGGTACTTCTTCCTGCGCCTGCACCAGACCCTGTGCTCCAGGCTGCTGAAGATCTACCGCCAGGCGCAGAAGCAG
CTTCTGGAGTATCGGACCGAGAAGGAGCGGGAGAAGCTGCTGTGTGAGGGCCGCAGGGAGAAGGGCAGCGACCCCGCCATGGAGCTGCGG
CTGAAGCAGCCCAGTGAAGTGGAGCTGGAGGAGTACTACCCGGCCTTCCTGGACATGGTGCGGAGCCTGCTGGAGGGCAGCATCGACCCC
ACGCAGTACGAGGACACCCTACGCGAGATGTTCACCATCCATGCCTACGTGGGCTTCACCATGGACAAGCTGGTGCAGAACATTGCGCGG
CAGCTGCACCACCTCGTGAGCGATGACGTCTGCCTGAAGGTGGTGGAGCTCTACCTGAACGAGAAGAAGCGGGGTGCCGCTGGTGGGAAC
CTGTCCTCCCGCTGCGTCCGCGCTGCTAGGGAGACCAGCTACCAGTGGAAGGCTGAGCGCTGCATGGCCGACGAGAACTGCTTCAAGGTG
ATGTTCCTGCAGCGCAAAGGGCAGGTGATCATGACCATCGAGCTCCTGGACACCGAGGAGGCCCAGACGGAGGACCCTGTGGAGGTCCAG
GACTCCAGTGGGGGTGACTCATGTGCTTCTGAGGAGGAACCAACCTTTGACCCCGACTATGAACCTGACTGGGCTGTCATCAGCACTGTG
CGGCCACAGCTCTGCCACTCAGAGCCCACGAGAGGTGCAGAGCCCAGCTGCCCCCAGGGCTCCTGGGCCTTCTCAGTGAGTCTGGGGGAG
CTAAAGTCCATCCGCCGCTCCAAGCCAGGCCTCAGCTGGGCCTACCTGGTTCTGGTGACCCAGGCTGGAGGTTCCCTGCCCGCACTGCAC
TTCCACCGCGGGGGCACCCGCGCCCTGCTCCGCGTCCTCAGCCGCTACCTGCTGTTGGCCAGCTCCCCGCAGGACTCCCGCCTCTACCTT
GTCTTCCCCCACGACTCCTCTGCTCTCTCCAACTCCTTCCACCACCTGCAGCTCTTTGACCAGGACAGCTCCAATGTGGTGTCACGCTTC
CTCCAGGATCCCTACTCCACCACCTTCAGCAGCTTCTCCCGAGTGACCAACTTCTTCCGGGGTGCCCTGCAGCCACAGCCTGAGGGAGCC
GCCTCCGACCTTCCCCCGCCACCCGACGATGAGCCCGAGCCTGGATTCGAGGTCATTTCCTGTGTGGAGCTGGGGCCTCGGCCAACCGTG
GAGCGGGGCCCTCCAGTTACAGAGGAGGAGTGGGCACGCCACGTGGGCCCTGAAGGTCGCCTGCAGCAGGTCCCTGAGCTGAAGAACCGG
ATCTTCTCGGGGGGTCTGAGCCCCAGCCTGCGGCGCGAGGCCTGGAAGTTCCTCCTAGGGTACCTCAGCTGGGAAGGCACAGCTGAGGAG
CACAAGGCCCACATACGCAAGAAAACGGATGAGTATTTCCGCATGAAGCTGCAGTGGAAATCTGTGAGCCCTGAGCAGGAGCGGAGAAAC
TCACTTCTGCATGGATACCGCAGCCTCATCGAAAGGGATGTGAGCCGCACTGACAGGACCAACAAGTTCTACGAGGGTCCCGAGAACCCG
GGGCTGGGCCTGCTGAACGATATCCTCCTCACCTACTGCATGTATCACTTCGACCTCGGCTACGTCCAGGGCATGAGTGATCTTCTCTCC
CCGATCCTCTACGTCATTCAGAACGAGGTGGATGCTTTCTGGTGTTTCTGTGGCTTCATGGAGCTCGTGCAAGGGAACTTTGAAGAGAGC
CAGGAGACCATGAAGCGGCAACTCGGGCGACTGCTGCTGCTCCTGAGGGTGCTGGACCCCCTGCTCTGCGACTTCCTGGATTCCCAGGAC
TCCGGCTCTCTCTGCTTCTGTTTCCGGTGGCTGCTCATCTGGTTCAAGAGGGAATTCCCCTTCCCGGATGTCCTTCGGCTGTGGGAGGTG
CTGTGGACAGGGCTCCCTGGCCCCAATCTGCACCTGCTGGTGGCCTGCGCCATCCTGGACATGGAGAGGGACACCCTCATGCTGTCCGGC
TTCGGCTCCAATGAGATCCTCAAGCACATCAACGAGCTGACTATGAAGCTGAGCGTGGAGGACGTGCTGACCCGCGCCGAGGCCCTGCAC
CGCCAGCTAACCGCCTGCCCCGAGCTGCCCCACAACGTGCAGGAGATCCTGGGGCTGGCCCCGCCCGCAGAGCCCCACAGCCCCTCGCCC
ACCGCCTCCCCGCTGCCTCTGTCGCCCACCCGGGCCCCGCCCACCCCGCCGCCCTCCACGGACACAGCCCCGCAGCCCGACAGCAGCCTG
GAGATCCTGCCCGAGGAGGAGGACGAGGGCGCCGACTCCTAACCCCGCCAGGCAGCCTCGTTCTGCACAGGCACTTTAGCCCGAGCCAGG

>81927_81927_1_SIN3B-TBC1D17_SIN3B_chr19_16987389_ENST00000248054_TBC1D17_chr19_50383536_ENST00000221543_length(amino acids)=1536AA_BP=953
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLF
HEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
EIYRSFLEILHTYQKEQLNTRGRPFRGMSEEEVFTEVANLFRGQEDLLSEFGQFLPEAKRSLFTGNGPCEMHSVQKNEHDKTPEHSRKRS
RPSLLRPVSAPAKKKMKLRGTKDLSIAAVGKYGTLQEFSFFDKVRRVLKSQEVYENFLRCIALFNQELVSGSELLQLVSPFLGKFPELFA
QFKSFLGVKELSFAPPMSDRSGDGISREIDYASCKRIGSSYRALPKTYQQPKCSGRTAICKEVLNDTWVSFPSWSEDSTFVSSKKTPYEE
QLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMAPEDQEKFRLDDSLGGTSEVIQRRAIYRIYGDKAPEIIESLKKNPVTAVPVVLK
RLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQAVNFKQNDTKALRSKSLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYEDRQIL
EDAAALISYYVKRQPAIQKEDQGTIHQLLHQFVPSLFFSQQLDLGASEESADEDRDSPQGQTTDPSERKKPAPGPHSSPPEEKGAFGDAP
ATEQPPLPPPAPHKPLDDVYSLFFANNNWYFFLRLHQTLCSRLLKIYRQAQKQLLEYRTEKEREKLLCEGRREKGSDPAMELRLKQPSEV
ELEEYYPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYVGFTMDKLVQNIARQLHHLVSDDVCLKVVELYLNEKKRGAAGGNLSSRCVR
AARETSYQWKAERCMADENCFKVMFLQRKGQVIMTIELLDTEEAQTEDPVEVQDSSGGDSCASEEEPTFDPDYEPDWAVISTVRPQLCHS
EPTRGAEPSCPQGSWAFSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQDSRLYLVFPHDSS
ALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQPQPEGAASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPPVT
EEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYR
SLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQ
LGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEIL
KHINELTMKLSVEDVLTRAEALHRQLTACPELPHNVQEILGLAPPAEPHSPSPTASPLPLSPTRAPPTPPPSTDTAPQPDSSLEILPEEE

--------------------------------------------------------------
>81927_81927_2_SIN3B-TBC1D17_SIN3B_chr19_16987389_ENST00000248054_TBC1D17_chr19_50383536_ENST00000535102_length(transcript)=4751nt_BP=2880nt
GGCGCAGCTCCGACTTCGGACATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGC
GCCCGCTGGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATC
CGCTTTGGCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATC
AGACGTGTCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCC
AAGAATGGCAAGTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTCAAGCAGCAG
GTGCCGTATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAA
ACCCGCTTCCTAGACCACCCAGAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAGAAGGAGCAGCTGAACACGAGGGGCCGG
CCATTCCGAGGCATGTCTGAAGAGGAGGTGTTCACCGAGGTGGCCAACCTCTTCCGGGGCCAGGAGGACCTGCTCTCAGAGTTTGGACAG
TTCCTGCCCGAAGCCAAGCGGTCTCTGTTCACAGGAAACGGGCCGTGCGAGATGCACAGCGTGCAGAAGAACGAGCACGACAAGACCCCG
GAGCACAGCAGGAAGCGCTCCCGGCCCTCGCTCCTCCGCCCCGTGTCTGCACCCGCCAAGAAAAAAATGAAACTTCGTGGTACCAAAGAC
CTGTCCATCGCTGCAGTGGGGAAGTACGGGACTCTGCAGGAATTTTCTTTCTTTGACAAGGTCCGCCGGGTGCTGAAGAGCCAGGAGGTG
TATGAAAACTTCCTCCGCTGCATCGCACTCTTCAACCAGGAGCTGGTGTCTGGCTCTGAGCTCCTGCAGCTCGTCAGCCCATTTCTGGGG
AAATTTCCAGAACTCTTTGCACAGTTCAAGTCCTTCCTGGGGGTAAAAGAGCTGTCCTTCGCGCCACCCATGAGCGACAGATCCGGGGAC
GGGATAAGCCGGGAAATTGATTATGCATCCTGCAAGCGCATAGGATCCAGCTACCGGGCACTCCCCAAAACCTACCAGCAGCCCAAGTGC
AGTGGGAGGACAGCCATCTGCAAGGAGGTACTGAACGACACCTGGGTCTCCTTCCCTTCCTGGTCTGAGGACTCCACGTTCGTCAGCTCC
AAGAAGACACCGTACGAGGAGCAGCTTCACCGCTGTGAGGACGAGCGCTTCGAGTTAGACGTTGTCCTGGAGACGAACCTGGCCACAATC
CGTGTGTTGGAAAGTGTGCAGAAGAAGCTATCTCGGATGGCGCCGGAAGACCAGGAGAAGTTCCGGCTGGACGACTCCCTGGGAGGCACG
TCGGAGGTGATCCAGCGCCGTGCCATTTATCGCATCTATGGCGACAAGGCCCCGGAGATCATCGAGAGCCTCAAGAAGAACCCTGTCACC
GCTGTCCCCGTTGTCCTGAAAAGACTGAAGGCCAAGGAAGAGGAGTGGCGGGAGGCCCAGCAGGGCTTCAACAAGATCTGGCGGGAGCAG
TATGAGAAGGCGTACCTCAAGTCCCTTGACCACCAGGCTGTGAACTTCAAGCAGAACGACACCAAGGCCCTGCGCTCCAAGAGCTTGCTC
AACGAGATCGAGAGCGTCTACGACGAGCACCAGGAGCAGCACTCGGAGGGCCGCAGTGCCCCCTCTAGCGAGCCGCACCTCATCTTTGTG
TACGAGGACCGGCAGATCCTGGAGGACGCAGCAGCGCTCATCAGCTACTACGTGAAGCGGCAGCCGGCCATCCAGAAGGAGGACCAGGGC
ACCATCCACCAGCTGCTGCACCAGTTCGTGCCCAGCCTCTTCTTCTCTCAGCAGCTGGACCTGGGCGCCTCCGAGGAGTCAGCTGATGAG
GACCGGGACAGCCCCCAGGGGCAGACCACAGACCCCAGTGAGCGGAAGAAGCCGGCGCCAGGACCCCACAGTAGCCCCCCAGAGGAGAAG
GGGGCCTTCGGGGATGCCCCGGCCACTGAGCAGCCACCCCTGCCGCCCCCAGCCCCGCACAAGCCCCTGGACGATGTCTACAGCCTATTT
TTTGCCAACAACAACTGGTACTTCTTCCTGCGCCTGCACCAGACCCTGTGCTCCAGGCTGCTGAAGATCTACCGCCAGGCGCAGAAGCAG
CTTCTGGAGTATCGGACCGAGAAGGAGCGGGAGAAGCTGCTGTGTGAGGGCCGCAGGGAGAAGGGCAGCGACCCCGCCATGGAGCTGCGG
CTGAAGCAGCCCAGTGAAGTGGAGCTGGAGGAGTACTACCCGGCCTTCCTGGACATGGTGCGGAGCCTGCTGGAGGGCAGCATCGACCCC
ACGCAGTACGAGGACACCCTACGCGAGATGTTCACCATCCATGCCTACGTGGGCTTCACCATGGACAAGCTGGTGCAGAACATTGCGCGG
CAGCTGCACCACCTCGTGAGCGATGACGTCTGCCTGAAGGTGGTGGAGCTCTACCTGAACGAGAAGAAGCGGGGTGCCGCTGGTGGGAAC
CTGTCCTCCCGCTGCGTCCGCGCTGCTAGGGAGACCAGCTACCAGTGGAAGGCTGAGCGCTGCATGGCCGACGAGAACTGCTTCAAGGTG
ATGTTCCTGCAGCGCAAAGGGCAGGTGATCATGACCATCGAGCTCCTGGACACCGAGGAGGCCCAGACGGAGGACCCTGTGGAGGTCCAG
GACTCCAGTGGGGGTGACTCATGTGCTTCTGAGGAGGAACCAACCTTTGACCCCGACTATGAACCTGACTGGGCTGTCATCAGCACTGTG
CGGCCACAGCTCTGCCACTCAGAGCCCACGAGAGGTGCAGAGCCCAGCTGCCCCCAGGGCTCCTGGGCCTTCTCAGTGAGTCTGGGGGAG
CTAAAGTCCATCCGCCGCTCCAAGCCAGGCCTCAGCTGGGCCTACCTGGTTCTGGTGACCCAGGCTGGAGGTTCCCTGCCCGCACTGCAC
TTCCACCGCGGGGGCACCCGCGCCCTGCTCCGCGTCCTCAGCCGCTACCTGCTGTTGGCCAGCTCCCCGCAGGACTCCCGCCTCTACCTT
GTCTTCCCCCACGACTCCTCTGCTCTCTCCAACTCCTTCCACCACCTGCAGCTCTTTGACCAGGACAGCTCCAATGTGGTGTCACGCTTC
CTCCAGGATCCCTACTCCACCACCTTCAGCAGCTTCTCCCGAGTGACCAACTTCTTCCGGGGTGCCCTGCAGCCACAGCCTGAGGGAGCC
GCCTCCGACCTTCCCCCGCCACCCGACGATGAGCCCGAGCCTGGATTCGAGGTCATTTCCTGTGTGGAGCTGGGGCCTCGGCCAACCGTG
GAGCGGGGCCCTCCAGTTACAGAGGAGGAGTGGGCACGCCACGTGGGCCCTGAAGGTCGCCTGCAGCAGGTCCCTGAGCTGAAGAACCGG
ATCTTCTCGGGGGGTCTGAGCCCCAGCCTGCGGCGCGAGGCCTGGAAGTTCCTCCTAGGGTACCTCAGCTGGGAAGGCACAGCTGAGGAG
CACAAGGCCCACATACGCAAGAAAACGGATGAGTATTTCCGCATGAAGCTGCAGTGGAAATCTGTGAGCCCTGAGCAGGAGCGGAGAAAC
TCACTTCTGCATGGATACCGCAGCCTCATCGAAAGGGATGTGAGCCGCACTGACAGGACCAACAAGTTCTACGAGGGTCCCGAGAACCCG
GGGCTGGGCCTGCTGAACGATATCCTCCTCACCTACTGCATGTATCACTTCGACCTCGGCTACGTCCAGGGCATGAGTGATCTTCTCTCC
CCGATCCTCTACGTCATTCAGAACGAGGTGGATGCTTTCTGGTGTTTCTGTGGCTTCATGGAGCTCGTGCAAGGGAACTTTGAAGAGAGC
CAGGAGACCATGAAGCGGCAACTCGGGCGACTGCTGCTGCTCCTGAGGGTGCTGGACCCCCTGCTCTGCGACTTCCTGGATTCCCAGGAC
TCCGGCTCTCTCTGCTTCTGTTTCCGGTGGCTGCTCATCTGGTTCAAGAGGGAATTCCCCTTCCCGGATGTCCTTCGGCTGTGGGAGGTG
CTGTGGACAGGGCTCCCTGGCCCCAATCTGCACCTGCTGGTGGCCTGCGCCATCCTGGACATGGAGAGGGACACCCTCATGCTGTCCGGC
TTCGGCTCCAATGAGATCCTCAAGCACATCAACGAGCTGACTATGAAGCTGAGCGTGGAGGACGTGCTGACCCGCGCCGAGGCCCTGCAC
CGCCAGCTAACCGCCTGCCCCGAGCTGCCCCACAACGTGCAGGAGATCCTGGGGCTGGCCCCGCCCGCAGAGCCCCACAGCCCCTCGCCC
ACCGCCTCCCCGCTGCCTCTGTCGCCCACCCGGGCCCCGCCCACCCCGCCGCCCTCCACGGACACAGCCCCGCAGCCCGACAGCAGCCTG
GAGATCCTGCCCGAGGAGGAGGACGAGGGCGCCGACTCCTAACCCCGCCAGGCAGCCTCGTTCTGCACAGGCACTTTAGCCCGAGCCAGG

>81927_81927_2_SIN3B-TBC1D17_SIN3B_chr19_16987389_ENST00000248054_TBC1D17_chr19_50383536_ENST00000535102_length(amino acids)=1536AA_BP=953
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLF
HEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
EIYRSFLEILHTYQKEQLNTRGRPFRGMSEEEVFTEVANLFRGQEDLLSEFGQFLPEAKRSLFTGNGPCEMHSVQKNEHDKTPEHSRKRS
RPSLLRPVSAPAKKKMKLRGTKDLSIAAVGKYGTLQEFSFFDKVRRVLKSQEVYENFLRCIALFNQELVSGSELLQLVSPFLGKFPELFA
QFKSFLGVKELSFAPPMSDRSGDGISREIDYASCKRIGSSYRALPKTYQQPKCSGRTAICKEVLNDTWVSFPSWSEDSTFVSSKKTPYEE
QLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMAPEDQEKFRLDDSLGGTSEVIQRRAIYRIYGDKAPEIIESLKKNPVTAVPVVLK
RLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQAVNFKQNDTKALRSKSLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYEDRQIL
EDAAALISYYVKRQPAIQKEDQGTIHQLLHQFVPSLFFSQQLDLGASEESADEDRDSPQGQTTDPSERKKPAPGPHSSPPEEKGAFGDAP
ATEQPPLPPPAPHKPLDDVYSLFFANNNWYFFLRLHQTLCSRLLKIYRQAQKQLLEYRTEKEREKLLCEGRREKGSDPAMELRLKQPSEV
ELEEYYPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYVGFTMDKLVQNIARQLHHLVSDDVCLKVVELYLNEKKRGAAGGNLSSRCVR
AARETSYQWKAERCMADENCFKVMFLQRKGQVIMTIELLDTEEAQTEDPVEVQDSSGGDSCASEEEPTFDPDYEPDWAVISTVRPQLCHS
EPTRGAEPSCPQGSWAFSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGGTRALLRVLSRYLLLASSPQDSRLYLVFPHDSS
ALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQPQPEGAASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPPVT
EEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYR
SLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQ
LGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEIL
KHINELTMKLSVEDVLTRAEALHRQLTACPELPHNVQEILGLAPPAEPHSPSPTASPLPLSPTRAPPTPPPSTDTAPQPDSSLEILPEEE

--------------------------------------------------------------
>81927_81927_3_SIN3B-TBC1D17_SIN3B_chr19_16987389_ENST00000379803_TBC1D17_chr19_50383536_ENST00000221543_length(transcript)=4841nt_BP=2969nt
CTCCGACTTCGGACATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGCGCCCGCT
GGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATCCGCTTTG
GCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATCAGACGTG
TCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCCAAGAATG
GCAAGTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTCAAGCAGCAGGTGCCGT
ATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAAACCCGCT
TCCTAGACCACCCAGAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAGAAGGAGCAGCTGAACACGAGGGGCCGGCCATTCC
GAGGCATGTCTGAAGAGGAGGTGTTCACCGAGGTGGCCAACCTCTTCCGGGGCCAGGAGGACCTGCTCTCAGAGTTTGGACAGTTCCTGC
CCGAAGCCAAGCGGTCTCTGTTCACAGGAAACGGGCCGTGCGAGATGCACAGCGTGCAGAAGAACGAGCACGACAAGACCCCGGAGCACA
GCAGGAAGCGCTCCCGGCCCTCGCTCCTCCGCCCCGTGTCTGCACCCGCCAAGAAAAAAATGAAACTTCGTGGTACCAAAGACCTGTCCA
TCGCTGCAGTGGGGAAGTACGGGACTCTGCAGGAATTTTCTTTCTTTGACAAGGTCCGCCGGGTGCTGAAGAGCCAGGAGGTGTATGAAA
ACTTCCTCCGCTGCATCGCACTCTTCAACCAGGAGCTGGTGTCTGGCTCTGAGCTCCTGCAGCTCGTCAGCCCATTTCTGGGGAAATTTC
CAGAACTCTTTGCACAGTTCAAGTCCTTCCTGGGGGTAAAAGAGCTGTCCTTCGCGCCACCCATGAGCGACAGATCCGGGGACGGGATAA
GCCGGGAAATTGATTATGCATCCTGCAAGCGCATAGGATCCAGCTACCGGGCACTCCCCAAAACCTACCAGCAGCCCAAGTGCAGTGGGA
GGACAGCCATCTGCAAGGAGCTTGACCATTGGACACTTCTCCAGGGTTCGTGGACAGACGATTACTGCATGTCCAAGTTCAAGAATACCT
GCTGGATTCCAGGATATAGTGCAGGGGTACTGAACGACACCTGGGTCTCCTTCCCTTCCTGGTCTGAGGACTCCACGTTCGTCAGCTCCA
AGAAGACACCGTACGAGGAGCAGCTTCACCGCTGTGAGGACGAGCGCTTCGAGTTAGACGTTGTCCTGGAGACGAACCTGGCCACAATCC
GTGTGTTGGAAAGTGTGCAGAAGAAGCTATCTCGGATGGCGCCGGAAGACCAGGAGAAGTTCCGGCTGGACGACTCCCTGGGAGGCACGT
CGGAGGTGATCCAGCGCCGTGCCATTTATCGCATCTATGGCGACAAGGCCCCGGAGATCATCGAGAGCCTCAAGAAGAACCCTGTCACCG
CTGTCCCCGTTGTCCTGAAAAGACTGAAGGCCAAGGAAGAGGAGTGGCGGGAGGCCCAGCAGGGCTTCAACAAGATCTGGCGGGAGCAGT
ATGAGAAGGCGTACCTCAAGTCCCTTGACCACCAGGCTGTGAACTTCAAGCAGAACGACACCAAGGCCCTGCGCTCCAAGAGCTTGCTCA
ACGAGATCGAGAGCGTCTACGACGAGCACCAGGAGCAGCACTCGGAGGGCCGCAGTGCCCCCTCTAGCGAGCCGCACCTCATCTTTGTGT
ACGAGGACCGGCAGATCCTGGAGGACGCAGCAGCGCTCATCAGCTACTACGTGAAGCGGCAGCCGGCCATCCAGAAGGAGGACCAGGGCA
CCATCCACCAGCTGCTGCACCAGTTCGTGCCCAGCCTCTTCTTCTCTCAGCAGCTGGACCTGGGCGCCTCCGAGGAGTCAGCTGATGAGG
ACCGGGACAGCCCCCAGGGGCAGACCACAGACCCCAGTGAGCGGAAGAAGCCGGCGCCAGGACCCCACAGTAGCCCCCCAGAGGAGAAGG
GGGCCTTCGGGGATGCCCCGGCCACTGAGCAGCCACCCCTGCCGCCCCCAGCCCCGCACAAGCCCCTGGACGATGTCTACAGCCTATTTT
TTGCCAACAACAACTGGTACTTCTTCCTGCGCCTGCACCAGACCCTGTGCTCCAGGCTGCTGAAGATCTACCGCCAGGCGCAGAAGCAGC
TTCTGGAGTATCGGACCGAGAAGGAGCGGGAGAAGCTGCTGTGTGAGGGCCGCAGGGAGAAGGGCAGCGACCCCGCCATGGAGCTGCGGC
TGAAGCAGCCCAGTGAAGTGGAGCTGGAGGAGTACTACCCGGCCTTCCTGGACATGGTGCGGAGCCTGCTGGAGGGCAGCATCGACCCCA
CGCAGTACGAGGACACCCTACGCGAGATGTTCACCATCCATGCCTACGTGGGCTTCACCATGGACAAGCTGGTGCAGAACATTGCGCGGC
AGCTGCACCACCTCGTGAGCGATGACGTCTGCCTGAAGGTGGTGGAGCTCTACCTGAACGAGAAGAAGCGGGGTGCCGCTGGTGGGAACC
TGTCCTCCCGCTGCGTCCGCGCTGCTAGGGAGACCAGCTACCAGTGGAAGGCTGAGCGCTGCATGGCCGACGAGAACTGCTTCAAGGTGA
TGTTCCTGCAGCGCAAAGGGCAGGTGATCATGACCATCGAGCTCCTGGACACCGAGGAGGCCCAGACGGAGGACCCTGTGGAGGTCCAGG
ACTCCAGTGGGGGTGACTCATGTGCTTCTGAGGAGGAACCAACCTTTGACCCCGACTATGAACCTGACTGGGCTGTCATCAGCACTGTGC
GGCCACAGCTCTGCCACTCAGAGCCCACGAGAGGTGCAGAGCCCAGCTGCCCCCAGGGCTCCTGGGCCTTCTCAGTGAGTCTGGGGGAGC
TAAAGTCCATCCGCCGCTCCAAGCCAGGCCTCAGCTGGGCCTACCTGGTTCTGGTGACCCAGGCTGGAGGTTCCCTGCCCGCACTGCACT
TCCACCGCGGGGGCACCCGCGCCCTGCTCCGCGTCCTCAGCCGCTACCTGCTGTTGGCCAGCTCCCCGCAGGACTCCCGCCTCTACCTTG
TCTTCCCCCACGACTCCTCTGCTCTCTCCAACTCCTTCCACCACCTGCAGCTCTTTGACCAGGACAGCTCCAATGTGGTGTCACGCTTCC
TCCAGGATCCCTACTCCACCACCTTCAGCAGCTTCTCCCGAGTGACCAACTTCTTCCGGGGTGCCCTGCAGCCACAGCCTGAGGGAGCCG
CCTCCGACCTTCCCCCGCCACCCGACGATGAGCCCGAGCCTGGATTCGAGGTCATTTCCTGTGTGGAGCTGGGGCCTCGGCCAACCGTGG
AGCGGGGCCCTCCAGTTACAGAGGAGGAGTGGGCACGCCACGTGGGCCCTGAAGGTCGCCTGCAGCAGGTCCCTGAGCTGAAGAACCGGA
TCTTCTCGGGGGGTCTGAGCCCCAGCCTGCGGCGCGAGGCCTGGAAGTTCCTCCTAGGGTACCTCAGCTGGGAAGGCACAGCTGAGGAGC
ACAAGGCCCACATACGCAAGAAAACGGATGAGTATTTCCGCATGAAGCTGCAGTGGAAATCTGTGAGCCCTGAGCAGGAGCGGAGAAACT
CACTTCTGCATGGATACCGCAGCCTCATCGAAAGGGATGTGAGCCGCACTGACAGGACCAACAAGTTCTACGAGGGTCCCGAGAACCCGG
GGCTGGGCCTGCTGAACGATATCCTCCTCACCTACTGCATGTATCACTTCGACCTCGGCTACGTCCAGGGCATGAGTGATCTTCTCTCCC
CGATCCTCTACGTCATTCAGAACGAGGTGGATGCTTTCTGGTGTTTCTGTGGCTTCATGGAGCTCGTGCAAGGGAACTTTGAAGAGAGCC
AGGAGACCATGAAGCGGCAACTCGGGCGACTGCTGCTGCTCCTGAGGGTGCTGGACCCCCTGCTCTGCGACTTCCTGGATTCCCAGGACT
CCGGCTCTCTCTGCTTCTGTTTCCGGTGGCTGCTCATCTGGTTCAAGAGGGAATTCCCCTTCCCGGATGTCCTTCGGCTGTGGGAGGTGC
TGTGGACAGGGCTCCCTGGCCCCAATCTGCACCTGCTGGTGGCCTGCGCCATCCTGGACATGGAGAGGGACACCCTCATGCTGTCCGGCT
TCGGCTCCAATGAGATCCTCAAGCACATCAACGAGCTGACTATGAAGCTGAGCGTGGAGGACGTGCTGACCCGCGCCGAGGCCCTGCACC
GCCAGCTAACCGCCTGCCCCGAGCTGCCCCACAACGTGCAGGAGATCCTGGGGCTGGCCCCGCCCGCAGAGCCCCACAGCCCCTCGCCCA
CCGCCTCCCCGCTGCCTCTGTCGCCCACCCGGGCCCCGCCCACCCCGCCGCCCTCCACGGACACAGCCCCGCAGCCCGACAGCAGCCTGG
AGATCCTGCCCGAGGAGGAGGACGAGGGCGCCGACTCCTAACCCCGCCAGGCAGCCTCGTTCTGCACAGGCACTTTAGCCCGAGCCAGGC

>81927_81927_3_SIN3B-TBC1D17_SIN3B_chr19_16987389_ENST00000379803_TBC1D17_chr19_50383536_ENST00000221543_length(amino acids)=1568AA_BP=985
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLF
HEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
EIYRSFLEILHTYQKEQLNTRGRPFRGMSEEEVFTEVANLFRGQEDLLSEFGQFLPEAKRSLFTGNGPCEMHSVQKNEHDKTPEHSRKRS
RPSLLRPVSAPAKKKMKLRGTKDLSIAAVGKYGTLQEFSFFDKVRRVLKSQEVYENFLRCIALFNQELVSGSELLQLVSPFLGKFPELFA
QFKSFLGVKELSFAPPMSDRSGDGISREIDYASCKRIGSSYRALPKTYQQPKCSGRTAICKELDHWTLLQGSWTDDYCMSKFKNTCWIPG
YSAGVLNDTWVSFPSWSEDSTFVSSKKTPYEEQLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMAPEDQEKFRLDDSLGGTSEVIQ
RRAIYRIYGDKAPEIIESLKKNPVTAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQAVNFKQNDTKALRSKSLLNEIES
VYDEHQEQHSEGRSAPSSEPHLIFVYEDRQILEDAAALISYYVKRQPAIQKEDQGTIHQLLHQFVPSLFFSQQLDLGASEESADEDRDSP
QGQTTDPSERKKPAPGPHSSPPEEKGAFGDAPATEQPPLPPPAPHKPLDDVYSLFFANNNWYFFLRLHQTLCSRLLKIYRQAQKQLLEYR
TEKEREKLLCEGRREKGSDPAMELRLKQPSEVELEEYYPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYVGFTMDKLVQNIARQLHHL
VSDDVCLKVVELYLNEKKRGAAGGNLSSRCVRAARETSYQWKAERCMADENCFKVMFLQRKGQVIMTIELLDTEEAQTEDPVEVQDSSGG
DSCASEEEPTFDPDYEPDWAVISTVRPQLCHSEPTRGAEPSCPQGSWAFSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGG
TRALLRVLSRYLLLASSPQDSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQPQPEGAASDLP
PPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHI
RKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYV
IQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGL
PGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELPHNVQEILGLAPPAEPHSPSPTASPL

--------------------------------------------------------------
>81927_81927_4_SIN3B-TBC1D17_SIN3B_chr19_16987389_ENST00000379803_TBC1D17_chr19_50383536_ENST00000535102_length(transcript)=4840nt_BP=2969nt
CTCCGACTTCGGACATGGCGCACGCTGGCGGTGGCAGCGGTGGCAGCGGTGCCGGCGGCCCCGCGGGCCGGGGGCTGAGCGGCGCCCGCT
GGGGTCGCTCGGGCTCCGCAGGCCACGAGAAGCTGCCGGTGCACGTAGAAGACGCCCTCACCTATCTGGACCAGGTGAAGATCCGCTTTG
GCAGCGACCCTGCCACCTACAACGGCTTCCTGGAGATCATGAAGGAGTTCAAAAGCCAGAGCATCGATACTCCTGGAGTCATCAGACGTG
TCTCGCAGCTCTTCCACGAGCACCCTGACCTCATTGTTGGATTCAACGCTTTTCTTCCCCTCGGATATAGAATAGACATTCCCAAGAATG
GCAAGTTAAACATACAGTCGCCTCTGACAAGCCAGGAGAATTCGCACAACCACGGGGACGGTGCAGAGGACTTCAAGCAGCAGGTGCCGT
ATAAAGAGGACAAACCCCAGGTGCCCCTGGAGTCCGATTCCGTGGAATTCAACAACGCCATCAGCTATGTGAATAAGATTAAAACCCGCT
TCCTAGACCACCCAGAAATCTACAGGTCATTCCTGGAGATCCTGCACACGTACCAGAAGGAGCAGCTGAACACGAGGGGCCGGCCATTCC
GAGGCATGTCTGAAGAGGAGGTGTTCACCGAGGTGGCCAACCTCTTCCGGGGCCAGGAGGACCTGCTCTCAGAGTTTGGACAGTTCCTGC
CCGAAGCCAAGCGGTCTCTGTTCACAGGAAACGGGCCGTGCGAGATGCACAGCGTGCAGAAGAACGAGCACGACAAGACCCCGGAGCACA
GCAGGAAGCGCTCCCGGCCCTCGCTCCTCCGCCCCGTGTCTGCACCCGCCAAGAAAAAAATGAAACTTCGTGGTACCAAAGACCTGTCCA
TCGCTGCAGTGGGGAAGTACGGGACTCTGCAGGAATTTTCTTTCTTTGACAAGGTCCGCCGGGTGCTGAAGAGCCAGGAGGTGTATGAAA
ACTTCCTCCGCTGCATCGCACTCTTCAACCAGGAGCTGGTGTCTGGCTCTGAGCTCCTGCAGCTCGTCAGCCCATTTCTGGGGAAATTTC
CAGAACTCTTTGCACAGTTCAAGTCCTTCCTGGGGGTAAAAGAGCTGTCCTTCGCGCCACCCATGAGCGACAGATCCGGGGACGGGATAA
GCCGGGAAATTGATTATGCATCCTGCAAGCGCATAGGATCCAGCTACCGGGCACTCCCCAAAACCTACCAGCAGCCCAAGTGCAGTGGGA
GGACAGCCATCTGCAAGGAGCTTGACCATTGGACACTTCTCCAGGGTTCGTGGACAGACGATTACTGCATGTCCAAGTTCAAGAATACCT
GCTGGATTCCAGGATATAGTGCAGGGGTACTGAACGACACCTGGGTCTCCTTCCCTTCCTGGTCTGAGGACTCCACGTTCGTCAGCTCCA
AGAAGACACCGTACGAGGAGCAGCTTCACCGCTGTGAGGACGAGCGCTTCGAGTTAGACGTTGTCCTGGAGACGAACCTGGCCACAATCC
GTGTGTTGGAAAGTGTGCAGAAGAAGCTATCTCGGATGGCGCCGGAAGACCAGGAGAAGTTCCGGCTGGACGACTCCCTGGGAGGCACGT
CGGAGGTGATCCAGCGCCGTGCCATTTATCGCATCTATGGCGACAAGGCCCCGGAGATCATCGAGAGCCTCAAGAAGAACCCTGTCACCG
CTGTCCCCGTTGTCCTGAAAAGACTGAAGGCCAAGGAAGAGGAGTGGCGGGAGGCCCAGCAGGGCTTCAACAAGATCTGGCGGGAGCAGT
ATGAGAAGGCGTACCTCAAGTCCCTTGACCACCAGGCTGTGAACTTCAAGCAGAACGACACCAAGGCCCTGCGCTCCAAGAGCTTGCTCA
ACGAGATCGAGAGCGTCTACGACGAGCACCAGGAGCAGCACTCGGAGGGCCGCAGTGCCCCCTCTAGCGAGCCGCACCTCATCTTTGTGT
ACGAGGACCGGCAGATCCTGGAGGACGCAGCAGCGCTCATCAGCTACTACGTGAAGCGGCAGCCGGCCATCCAGAAGGAGGACCAGGGCA
CCATCCACCAGCTGCTGCACCAGTTCGTGCCCAGCCTCTTCTTCTCTCAGCAGCTGGACCTGGGCGCCTCCGAGGAGTCAGCTGATGAGG
ACCGGGACAGCCCCCAGGGGCAGACCACAGACCCCAGTGAGCGGAAGAAGCCGGCGCCAGGACCCCACAGTAGCCCCCCAGAGGAGAAGG
GGGCCTTCGGGGATGCCCCGGCCACTGAGCAGCCACCCCTGCCGCCCCCAGCCCCGCACAAGCCCCTGGACGATGTCTACAGCCTATTTT
TTGCCAACAACAACTGGTACTTCTTCCTGCGCCTGCACCAGACCCTGTGCTCCAGGCTGCTGAAGATCTACCGCCAGGCGCAGAAGCAGC
TTCTGGAGTATCGGACCGAGAAGGAGCGGGAGAAGCTGCTGTGTGAGGGCCGCAGGGAGAAGGGCAGCGACCCCGCCATGGAGCTGCGGC
TGAAGCAGCCCAGTGAAGTGGAGCTGGAGGAGTACTACCCGGCCTTCCTGGACATGGTGCGGAGCCTGCTGGAGGGCAGCATCGACCCCA
CGCAGTACGAGGACACCCTACGCGAGATGTTCACCATCCATGCCTACGTGGGCTTCACCATGGACAAGCTGGTGCAGAACATTGCGCGGC
AGCTGCACCACCTCGTGAGCGATGACGTCTGCCTGAAGGTGGTGGAGCTCTACCTGAACGAGAAGAAGCGGGGTGCCGCTGGTGGGAACC
TGTCCTCCCGCTGCGTCCGCGCTGCTAGGGAGACCAGCTACCAGTGGAAGGCTGAGCGCTGCATGGCCGACGAGAACTGCTTCAAGGTGA
TGTTCCTGCAGCGCAAAGGGCAGGTGATCATGACCATCGAGCTCCTGGACACCGAGGAGGCCCAGACGGAGGACCCTGTGGAGGTCCAGG
ACTCCAGTGGGGGTGACTCATGTGCTTCTGAGGAGGAACCAACCTTTGACCCCGACTATGAACCTGACTGGGCTGTCATCAGCACTGTGC
GGCCACAGCTCTGCCACTCAGAGCCCACGAGAGGTGCAGAGCCCAGCTGCCCCCAGGGCTCCTGGGCCTTCTCAGTGAGTCTGGGGGAGC
TAAAGTCCATCCGCCGCTCCAAGCCAGGCCTCAGCTGGGCCTACCTGGTTCTGGTGACCCAGGCTGGAGGTTCCCTGCCCGCACTGCACT
TCCACCGCGGGGGCACCCGCGCCCTGCTCCGCGTCCTCAGCCGCTACCTGCTGTTGGCCAGCTCCCCGCAGGACTCCCGCCTCTACCTTG
TCTTCCCCCACGACTCCTCTGCTCTCTCCAACTCCTTCCACCACCTGCAGCTCTTTGACCAGGACAGCTCCAATGTGGTGTCACGCTTCC
TCCAGGATCCCTACTCCACCACCTTCAGCAGCTTCTCCCGAGTGACCAACTTCTTCCGGGGTGCCCTGCAGCCACAGCCTGAGGGAGCCG
CCTCCGACCTTCCCCCGCCACCCGACGATGAGCCCGAGCCTGGATTCGAGGTCATTTCCTGTGTGGAGCTGGGGCCTCGGCCAACCGTGG
AGCGGGGCCCTCCAGTTACAGAGGAGGAGTGGGCACGCCACGTGGGCCCTGAAGGTCGCCTGCAGCAGGTCCCTGAGCTGAAGAACCGGA
TCTTCTCGGGGGGTCTGAGCCCCAGCCTGCGGCGCGAGGCCTGGAAGTTCCTCCTAGGGTACCTCAGCTGGGAAGGCACAGCTGAGGAGC
ACAAGGCCCACATACGCAAGAAAACGGATGAGTATTTCCGCATGAAGCTGCAGTGGAAATCTGTGAGCCCTGAGCAGGAGCGGAGAAACT
CACTTCTGCATGGATACCGCAGCCTCATCGAAAGGGATGTGAGCCGCACTGACAGGACCAACAAGTTCTACGAGGGTCCCGAGAACCCGG
GGCTGGGCCTGCTGAACGATATCCTCCTCACCTACTGCATGTATCACTTCGACCTCGGCTACGTCCAGGGCATGAGTGATCTTCTCTCCC
CGATCCTCTACGTCATTCAGAACGAGGTGGATGCTTTCTGGTGTTTCTGTGGCTTCATGGAGCTCGTGCAAGGGAACTTTGAAGAGAGCC
AGGAGACCATGAAGCGGCAACTCGGGCGACTGCTGCTGCTCCTGAGGGTGCTGGACCCCCTGCTCTGCGACTTCCTGGATTCCCAGGACT
CCGGCTCTCTCTGCTTCTGTTTCCGGTGGCTGCTCATCTGGTTCAAGAGGGAATTCCCCTTCCCGGATGTCCTTCGGCTGTGGGAGGTGC
TGTGGACAGGGCTCCCTGGCCCCAATCTGCACCTGCTGGTGGCCTGCGCCATCCTGGACATGGAGAGGGACACCCTCATGCTGTCCGGCT
TCGGCTCCAATGAGATCCTCAAGCACATCAACGAGCTGACTATGAAGCTGAGCGTGGAGGACGTGCTGACCCGCGCCGAGGCCCTGCACC
GCCAGCTAACCGCCTGCCCCGAGCTGCCCCACAACGTGCAGGAGATCCTGGGGCTGGCCCCGCCCGCAGAGCCCCACAGCCCCTCGCCCA
CCGCCTCCCCGCTGCCTCTGTCGCCCACCCGGGCCCCGCCCACCCCGCCGCCCTCCACGGACACAGCCCCGCAGCCCGACAGCAGCCTGG
AGATCCTGCCCGAGGAGGAGGACGAGGGCGCCGACTCCTAACCCCGCCAGGCAGCCTCGTTCTGCACAGGCACTTTAGCCCGAGCCAGGC

>81927_81927_4_SIN3B-TBC1D17_SIN3B_chr19_16987389_ENST00000379803_TBC1D17_chr19_50383536_ENST00000535102_length(amino acids)=1568AA_BP=985
MAHAGGGSGGSGAGGPAGRGLSGARWGRSGSAGHEKLPVHVEDALTYLDQVKIRFGSDPATYNGFLEIMKEFKSQSIDTPGVIRRVSQLF
HEHPDLIVGFNAFLPLGYRIDIPKNGKLNIQSPLTSQENSHNHGDGAEDFKQQVPYKEDKPQVPLESDSVEFNNAISYVNKIKTRFLDHP
EIYRSFLEILHTYQKEQLNTRGRPFRGMSEEEVFTEVANLFRGQEDLLSEFGQFLPEAKRSLFTGNGPCEMHSVQKNEHDKTPEHSRKRS
RPSLLRPVSAPAKKKMKLRGTKDLSIAAVGKYGTLQEFSFFDKVRRVLKSQEVYENFLRCIALFNQELVSGSELLQLVSPFLGKFPELFA
QFKSFLGVKELSFAPPMSDRSGDGISREIDYASCKRIGSSYRALPKTYQQPKCSGRTAICKELDHWTLLQGSWTDDYCMSKFKNTCWIPG
YSAGVLNDTWVSFPSWSEDSTFVSSKKTPYEEQLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMAPEDQEKFRLDDSLGGTSEVIQ
RRAIYRIYGDKAPEIIESLKKNPVTAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQAVNFKQNDTKALRSKSLLNEIES
VYDEHQEQHSEGRSAPSSEPHLIFVYEDRQILEDAAALISYYVKRQPAIQKEDQGTIHQLLHQFVPSLFFSQQLDLGASEESADEDRDSP
QGQTTDPSERKKPAPGPHSSPPEEKGAFGDAPATEQPPLPPPAPHKPLDDVYSLFFANNNWYFFLRLHQTLCSRLLKIYRQAQKQLLEYR
TEKEREKLLCEGRREKGSDPAMELRLKQPSEVELEEYYPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYVGFTMDKLVQNIARQLHHL
VSDDVCLKVVELYLNEKKRGAAGGNLSSRCVRAARETSYQWKAERCMADENCFKVMFLQRKGQVIMTIELLDTEEAQTEDPVEVQDSSGG
DSCASEEEPTFDPDYEPDWAVISTVRPQLCHSEPTRGAEPSCPQGSWAFSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLPALHFHRGG
TRALLRVLSRYLLLASSPQDSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQPQPEGAASDLP
PPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGTAEEHKAHI
RKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSDLLSPILYV
IQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRLWEVLWTGL
PGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELPHNVQEILGLAPPAEPHSPSPTASPL

--------------------------------------------------------------
>81927_81927_5_SIN3B-TBC1D17_SIN3B_chr19_16987389_ENST00000595541_TBC1D17_chr19_50383536_ENST00000221543_length(transcript)=3871nt_BP=1999nt
CCAAAAAATGACAATACAGCAATAAAGCGTAATCCACATTTTAAGAATGCAGTGTAACAATGATCTACACAGCATTTACATTGCATTAGG
TATAAGTATTCTAGAGATGATTTTGCATAGGATATATGCAAATAGGATTCCATTGGACATCAGGGACTTGAGTATCTGTGGATTTGGGTC
TTCAGGGGTGGTTCTGGAACCAATCTCCCAGGATACCAAGGGAGTGTCCACTTGACCAAAGTCATGTTTTTCCTTAAAAACTTTATGCAC
CTTCCCATTTGTATAAGGCAGTTGGTATTATGTATCAGGATGGTATTATGTATCTTGGTACTTTCTACACTGGCTAACAGTAAATCTTGG
CTCCTGGGGCATGCAGCGTCATTCACGGCATTTCCTCTTGGTGCAGGTACTGAACGACACCTGGGTCTCCTTCCCTTCCTGGTCTGAGGA
CTCCACGTTCGTCAGCTCCAAGAAGACACCGTACGAGGAGCAGCTTCACCGCTGTGAGGACGAGCGCTTCGAGTTAGACGTTGTCCTGGA
GACGAACCTGGCCACAATCCGTGTGTTGGAAAGTGTGCAGAAGAAGCTATCTCGGATGGCGCCGGAAGACCAGGAGAAGTTCCGGCTGGA
CGACTCCCTGGGAGGCACGTCGGAGGTGATCCAGCGCCGTGCCATTTATCGCATCTATGGCGACAAGGCCCCGGAGATCATCGAGAGCCT
CAAGAAGAACCCTGTCACCGCTGTCCCCGTTGTCCTGAAAAGACTGAAGGCCAAGGAAGAGGAGTGGCGGGAGGCCCAGCAGGGCTTCAA
CAAGATCTGGCGGGAGCAGTATGAGAAGGCGTACCTCAAGTCCCTTGACCACCAGGCTGTGAACTTCAAGCAGAACGACACCAAGGCCCT
GCGCTCCAAGAGCTTGCTCAACGAGATCGAGAGCGTCTACGACGAGCACCAGGAGCAGCACTCGGAGGGCCGCAGTGCCCCCTCTAGCGA
GCCGCACCTCATCTTTGTGTACGAGGACCGGCAGATCCTGGAGGACGCAGCAGCGCTCATCAGCTACTACGTGAAGCGGCAGCCGGCCAT
CCAGAAGGAGGACCAGGGCACCATCCACCAGCTGCTGCACCAGTTCGTGCCCAGCCTCTTCTTCTCTCAGCAGCTGGACCTGGGCGCCTC
CGAGGAGTCAGCTGATGAGGACCGGGACAGCCCCCAGGGGCAGACCACAGACCCCAGTGAGCGGAAGAAGCCGGCGCCAGGACCCCACAG
TAGCCCCCCAGAGGAGAAGGGGGCCTTCGGGGATGCCCCGGCCACTGAGCAGCCACCCCTGCCGCCCCCAGCCCCGCACAAGCCCCTGGA
CGATGTCTACAGCCTATTTTTTGCCAACAACAACTGGTACTTCTTCCTGCGCCTGCACCAGACCCTGTGCTCCAGGCTGCTGAAGATCTA
CCGCCAGGCGCAGAAGCAGCTTCTGGAGTATCGGACCGAGAAGGAGCGGGAGAAGCTGCTGTGTGAGGGCCGCAGGGAGAAGGGCAGCGA
CCCCGCCATGGAGCTGCGGCTGAAGCAGCCCAGTGAAGTGGAGCTGGAGGAGTACTACCCGGCCTTCCTGGACATGGTGCGGAGCCTGCT
GGAGGGCAGCATCGACCCCACGCAGTACGAGGACACCCTACGCGAGATGTTCACCATCCATGCCTACGTGGGCTTCACCATGGACAAGCT
GGTGCAGAACATTGCGCGGCAGCTGCACCACCTCGTGAGCGATGACGTCTGCCTGAAGGTGGTGGAGCTCTACCTGAACGAGAAGAAGCG
GGGTGCCGCTGGTGGGAACCTGTCCTCCCGCTGCGTCCGCGCTGCTAGGGAGACCAGCTACCAGTGGAAGGCTGAGCGCTGCATGGCCGA
CGAGAACTGCTTCAAGGTGATGTTCCTGCAGCGCAAAGGGCAGGTGATCATGACCATCGAGCTCCTGGACACCGAGGAGGCCCAGACGGA
GGACCCTGTGGAGGTCCAGGACTCCAGTGGGGGTGACTCATGTGCTTCTGAGGAGGAACCAACCTTTGACCCCGACTATGAACCTGACTG
GGCTGTCATCAGCACTGTGCGGCCACAGCTCTGCCACTCAGAGCCCACGAGAGGTGCAGAGCCCAGCTGCCCCCAGGGCTCCTGGGCCTT
CTCAGTGAGTCTGGGGGAGCTAAAGTCCATCCGCCGCTCCAAGCCAGGCCTCAGCTGGGCCTACCTGGTTCTGGTGACCCAGGCTGGAGG
TTCCCTGCCCGCACTGCACTTCCACCGCGGGGGCACCCGCGCCCTGCTCCGCGTCCTCAGCCGCTACCTGCTGTTGGCCAGCTCCCCGCA
GGACTCCCGCCTCTACCTTGTCTTCCCCCACGACTCCTCTGCTCTCTCCAACTCCTTCCACCACCTGCAGCTCTTTGACCAGGACAGCTC
CAATGTGGTGTCACGCTTCCTCCAGGATCCCTACTCCACCACCTTCAGCAGCTTCTCCCGAGTGACCAACTTCTTCCGGGGTGCCCTGCA
GCCACAGCCTGAGGGAGCCGCCTCCGACCTTCCCCCGCCACCCGACGATGAGCCCGAGCCTGGATTCGAGGTCATTTCCTGTGTGGAGCT
GGGGCCTCGGCCAACCGTGGAGCGGGGCCCTCCAGTTACAGAGGAGGAGTGGGCACGCCACGTGGGCCCTGAAGGTCGCCTGCAGCAGGT
CCCTGAGCTGAAGAACCGGATCTTCTCGGGGGGTCTGAGCCCCAGCCTGCGGCGCGAGGCCTGGAAGTTCCTCCTAGGGTACCTCAGCTG
GGAAGGCACAGCTGAGGAGCACAAGGCCCACATACGCAAGAAAACGGATGAGTATTTCCGCATGAAGCTGCAGTGGAAATCTGTGAGCCC
TGAGCAGGAGCGGAGAAACTCACTTCTGCATGGATACCGCAGCCTCATCGAAAGGGATGTGAGCCGCACTGACAGGACCAACAAGTTCTA
CGAGGGTCCCGAGAACCCGGGGCTGGGCCTGCTGAACGATATCCTCCTCACCTACTGCATGTATCACTTCGACCTCGGCTACGTCCAGGG
CATGAGTGATCTTCTCTCCCCGATCCTCTACGTCATTCAGAACGAGGTGGATGCTTTCTGGTGTTTCTGTGGCTTCATGGAGCTCGTGCA
AGGGAACTTTGAAGAGAGCCAGGAGACCATGAAGCGGCAACTCGGGCGACTGCTGCTGCTCCTGAGGGTGCTGGACCCCCTGCTCTGCGA
CTTCCTGGATTCCCAGGACTCCGGCTCTCTCTGCTTCTGTTTCCGGTGGCTGCTCATCTGGTTCAAGAGGGAATTCCCCTTCCCGGATGT
CCTTCGGCTGTGGGAGGTGCTGTGGACAGGGCTCCCTGGCCCCAATCTGCACCTGCTGGTGGCCTGCGCCATCCTGGACATGGAGAGGGA
CACCCTCATGCTGTCCGGCTTCGGCTCCAATGAGATCCTCAAGCACATCAACGAGCTGACTATGAAGCTGAGCGTGGAGGACGTGCTGAC
CCGCGCCGAGGCCCTGCACCGCCAGCTAACCGCCTGCCCCGAGCTGCCCCACAACGTGCAGGAGATCCTGGGGCTGGCCCCGCCCGCAGA
GCCCCACAGCCCCTCGCCCACCGCCTCCCCGCTGCCTCTGTCGCCCACCCGGGCCCCGCCCACCCCGCCGCCCTCCACGGACACAGCCCC
GCAGCCCGACAGCAGCCTGGAGATCCTGCCCGAGGAGGAGGACGAGGGCGCCGACTCCTAACCCCGCCAGGCAGCCTCGTTCTGCACAGG
CACTTTAGCCCGAGCCAGGCACACCTGCGAGGGGGCAGGTGTGCTCCGCCGCCCTGCTGATAAGCTGGCTTCATTAAACTGACACTTCTC

>81927_81927_5_SIN3B-TBC1D17_SIN3B_chr19_16987389_ENST00000595541_TBC1D17_chr19_50383536_ENST00000221543_length(amino acids)=1126AA_BP=543
MQRHSRHFLLVQVLNDTWVSFPSWSEDSTFVSSKKTPYEEQLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMAPEDQEKFRLDDSL
GGTSEVIQRRAIYRIYGDKAPEIIESLKKNPVTAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQAVNFKQNDTKALRSK
SLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYEDRQILEDAAALISYYVKRQPAIQKEDQGTIHQLLHQFVPSLFFSQQLDLGASEES
ADEDRDSPQGQTTDPSERKKPAPGPHSSPPEEKGAFGDAPATEQPPLPPPAPHKPLDDVYSLFFANNNWYFFLRLHQTLCSRLLKIYRQA
QKQLLEYRTEKEREKLLCEGRREKGSDPAMELRLKQPSEVELEEYYPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYVGFTMDKLVQN
IARQLHHLVSDDVCLKVVELYLNEKKRGAAGGNLSSRCVRAARETSYQWKAERCMADENCFKVMFLQRKGQVIMTIELLDTEEAQTEDPV
EVQDSSGGDSCASEEEPTFDPDYEPDWAVISTVRPQLCHSEPTRGAEPSCPQGSWAFSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLP
ALHFHRGGTRALLRVLSRYLLLASSPQDSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQPQP
EGAASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGT
AEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSD
LLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRL
WEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELPHNVQEILGLAPPAEPHS

--------------------------------------------------------------
>81927_81927_6_SIN3B-TBC1D17_SIN3B_chr19_16987389_ENST00000595541_TBC1D17_chr19_50383536_ENST00000535102_length(transcript)=3870nt_BP=1999nt
CCAAAAAATGACAATACAGCAATAAAGCGTAATCCACATTTTAAGAATGCAGTGTAACAATGATCTACACAGCATTTACATTGCATTAGG
TATAAGTATTCTAGAGATGATTTTGCATAGGATATATGCAAATAGGATTCCATTGGACATCAGGGACTTGAGTATCTGTGGATTTGGGTC
TTCAGGGGTGGTTCTGGAACCAATCTCCCAGGATACCAAGGGAGTGTCCACTTGACCAAAGTCATGTTTTTCCTTAAAAACTTTATGCAC
CTTCCCATTTGTATAAGGCAGTTGGTATTATGTATCAGGATGGTATTATGTATCTTGGTACTTTCTACACTGGCTAACAGTAAATCTTGG
CTCCTGGGGCATGCAGCGTCATTCACGGCATTTCCTCTTGGTGCAGGTACTGAACGACACCTGGGTCTCCTTCCCTTCCTGGTCTGAGGA
CTCCACGTTCGTCAGCTCCAAGAAGACACCGTACGAGGAGCAGCTTCACCGCTGTGAGGACGAGCGCTTCGAGTTAGACGTTGTCCTGGA
GACGAACCTGGCCACAATCCGTGTGTTGGAAAGTGTGCAGAAGAAGCTATCTCGGATGGCGCCGGAAGACCAGGAGAAGTTCCGGCTGGA
CGACTCCCTGGGAGGCACGTCGGAGGTGATCCAGCGCCGTGCCATTTATCGCATCTATGGCGACAAGGCCCCGGAGATCATCGAGAGCCT
CAAGAAGAACCCTGTCACCGCTGTCCCCGTTGTCCTGAAAAGACTGAAGGCCAAGGAAGAGGAGTGGCGGGAGGCCCAGCAGGGCTTCAA
CAAGATCTGGCGGGAGCAGTATGAGAAGGCGTACCTCAAGTCCCTTGACCACCAGGCTGTGAACTTCAAGCAGAACGACACCAAGGCCCT
GCGCTCCAAGAGCTTGCTCAACGAGATCGAGAGCGTCTACGACGAGCACCAGGAGCAGCACTCGGAGGGCCGCAGTGCCCCCTCTAGCGA
GCCGCACCTCATCTTTGTGTACGAGGACCGGCAGATCCTGGAGGACGCAGCAGCGCTCATCAGCTACTACGTGAAGCGGCAGCCGGCCAT
CCAGAAGGAGGACCAGGGCACCATCCACCAGCTGCTGCACCAGTTCGTGCCCAGCCTCTTCTTCTCTCAGCAGCTGGACCTGGGCGCCTC
CGAGGAGTCAGCTGATGAGGACCGGGACAGCCCCCAGGGGCAGACCACAGACCCCAGTGAGCGGAAGAAGCCGGCGCCAGGACCCCACAG
TAGCCCCCCAGAGGAGAAGGGGGCCTTCGGGGATGCCCCGGCCACTGAGCAGCCACCCCTGCCGCCCCCAGCCCCGCACAAGCCCCTGGA
CGATGTCTACAGCCTATTTTTTGCCAACAACAACTGGTACTTCTTCCTGCGCCTGCACCAGACCCTGTGCTCCAGGCTGCTGAAGATCTA
CCGCCAGGCGCAGAAGCAGCTTCTGGAGTATCGGACCGAGAAGGAGCGGGAGAAGCTGCTGTGTGAGGGCCGCAGGGAGAAGGGCAGCGA
CCCCGCCATGGAGCTGCGGCTGAAGCAGCCCAGTGAAGTGGAGCTGGAGGAGTACTACCCGGCCTTCCTGGACATGGTGCGGAGCCTGCT
GGAGGGCAGCATCGACCCCACGCAGTACGAGGACACCCTACGCGAGATGTTCACCATCCATGCCTACGTGGGCTTCACCATGGACAAGCT
GGTGCAGAACATTGCGCGGCAGCTGCACCACCTCGTGAGCGATGACGTCTGCCTGAAGGTGGTGGAGCTCTACCTGAACGAGAAGAAGCG
GGGTGCCGCTGGTGGGAACCTGTCCTCCCGCTGCGTCCGCGCTGCTAGGGAGACCAGCTACCAGTGGAAGGCTGAGCGCTGCATGGCCGA
CGAGAACTGCTTCAAGGTGATGTTCCTGCAGCGCAAAGGGCAGGTGATCATGACCATCGAGCTCCTGGACACCGAGGAGGCCCAGACGGA
GGACCCTGTGGAGGTCCAGGACTCCAGTGGGGGTGACTCATGTGCTTCTGAGGAGGAACCAACCTTTGACCCCGACTATGAACCTGACTG
GGCTGTCATCAGCACTGTGCGGCCACAGCTCTGCCACTCAGAGCCCACGAGAGGTGCAGAGCCCAGCTGCCCCCAGGGCTCCTGGGCCTT
CTCAGTGAGTCTGGGGGAGCTAAAGTCCATCCGCCGCTCCAAGCCAGGCCTCAGCTGGGCCTACCTGGTTCTGGTGACCCAGGCTGGAGG
TTCCCTGCCCGCACTGCACTTCCACCGCGGGGGCACCCGCGCCCTGCTCCGCGTCCTCAGCCGCTACCTGCTGTTGGCCAGCTCCCCGCA
GGACTCCCGCCTCTACCTTGTCTTCCCCCACGACTCCTCTGCTCTCTCCAACTCCTTCCACCACCTGCAGCTCTTTGACCAGGACAGCTC
CAATGTGGTGTCACGCTTCCTCCAGGATCCCTACTCCACCACCTTCAGCAGCTTCTCCCGAGTGACCAACTTCTTCCGGGGTGCCCTGCA
GCCACAGCCTGAGGGAGCCGCCTCCGACCTTCCCCCGCCACCCGACGATGAGCCCGAGCCTGGATTCGAGGTCATTTCCTGTGTGGAGCT
GGGGCCTCGGCCAACCGTGGAGCGGGGCCCTCCAGTTACAGAGGAGGAGTGGGCACGCCACGTGGGCCCTGAAGGTCGCCTGCAGCAGGT
CCCTGAGCTGAAGAACCGGATCTTCTCGGGGGGTCTGAGCCCCAGCCTGCGGCGCGAGGCCTGGAAGTTCCTCCTAGGGTACCTCAGCTG
GGAAGGCACAGCTGAGGAGCACAAGGCCCACATACGCAAGAAAACGGATGAGTATTTCCGCATGAAGCTGCAGTGGAAATCTGTGAGCCC
TGAGCAGGAGCGGAGAAACTCACTTCTGCATGGATACCGCAGCCTCATCGAAAGGGATGTGAGCCGCACTGACAGGACCAACAAGTTCTA
CGAGGGTCCCGAGAACCCGGGGCTGGGCCTGCTGAACGATATCCTCCTCACCTACTGCATGTATCACTTCGACCTCGGCTACGTCCAGGG
CATGAGTGATCTTCTCTCCCCGATCCTCTACGTCATTCAGAACGAGGTGGATGCTTTCTGGTGTTTCTGTGGCTTCATGGAGCTCGTGCA
AGGGAACTTTGAAGAGAGCCAGGAGACCATGAAGCGGCAACTCGGGCGACTGCTGCTGCTCCTGAGGGTGCTGGACCCCCTGCTCTGCGA
CTTCCTGGATTCCCAGGACTCCGGCTCTCTCTGCTTCTGTTTCCGGTGGCTGCTCATCTGGTTCAAGAGGGAATTCCCCTTCCCGGATGT
CCTTCGGCTGTGGGAGGTGCTGTGGACAGGGCTCCCTGGCCCCAATCTGCACCTGCTGGTGGCCTGCGCCATCCTGGACATGGAGAGGGA
CACCCTCATGCTGTCCGGCTTCGGCTCCAATGAGATCCTCAAGCACATCAACGAGCTGACTATGAAGCTGAGCGTGGAGGACGTGCTGAC
CCGCGCCGAGGCCCTGCACCGCCAGCTAACCGCCTGCCCCGAGCTGCCCCACAACGTGCAGGAGATCCTGGGGCTGGCCCCGCCCGCAGA
GCCCCACAGCCCCTCGCCCACCGCCTCCCCGCTGCCTCTGTCGCCCACCCGGGCCCCGCCCACCCCGCCGCCCTCCACGGACACAGCCCC
GCAGCCCGACAGCAGCCTGGAGATCCTGCCCGAGGAGGAGGACGAGGGCGCCGACTCCTAACCCCGCCAGGCAGCCTCGTTCTGCACAGG
CACTTTAGCCCGAGCCAGGCACACCTGCGAGGGGGCAGGTGTGCTCCGCCGCCCTGCTGATAAGCTGGCTTCATTAAACTGACACTTCTC

>81927_81927_6_SIN3B-TBC1D17_SIN3B_chr19_16987389_ENST00000595541_TBC1D17_chr19_50383536_ENST00000535102_length(amino acids)=1126AA_BP=543
MQRHSRHFLLVQVLNDTWVSFPSWSEDSTFVSSKKTPYEEQLHRCEDERFELDVVLETNLATIRVLESVQKKLSRMAPEDQEKFRLDDSL
GGTSEVIQRRAIYRIYGDKAPEIIESLKKNPVTAVPVVLKRLKAKEEEWREAQQGFNKIWREQYEKAYLKSLDHQAVNFKQNDTKALRSK
SLLNEIESVYDEHQEQHSEGRSAPSSEPHLIFVYEDRQILEDAAALISYYVKRQPAIQKEDQGTIHQLLHQFVPSLFFSQQLDLGASEES
ADEDRDSPQGQTTDPSERKKPAPGPHSSPPEEKGAFGDAPATEQPPLPPPAPHKPLDDVYSLFFANNNWYFFLRLHQTLCSRLLKIYRQA
QKQLLEYRTEKEREKLLCEGRREKGSDPAMELRLKQPSEVELEEYYPAFLDMVRSLLEGSIDPTQYEDTLREMFTIHAYVGFTMDKLVQN
IARQLHHLVSDDVCLKVVELYLNEKKRGAAGGNLSSRCVRAARETSYQWKAERCMADENCFKVMFLQRKGQVIMTIELLDTEEAQTEDPV
EVQDSSGGDSCASEEEPTFDPDYEPDWAVISTVRPQLCHSEPTRGAEPSCPQGSWAFSVSLGELKSIRRSKPGLSWAYLVLVTQAGGSLP
ALHFHRGGTRALLRVLSRYLLLASSPQDSRLYLVFPHDSSALSNSFHHLQLFDQDSSNVVSRFLQDPYSTTFSSFSRVTNFFRGALQPQP
EGAASDLPPPPDDEPEPGFEVISCVELGPRPTVERGPPVTEEEWARHVGPEGRLQQVPELKNRIFSGGLSPSLRREAWKFLLGYLSWEGT
AEEHKAHIRKKTDEYFRMKLQWKSVSPEQERRNSLLHGYRSLIERDVSRTDRTNKFYEGPENPGLGLLNDILLTYCMYHFDLGYVQGMSD
LLSPILYVIQNEVDAFWCFCGFMELVQGNFEESQETMKRQLGRLLLLLRVLDPLLCDFLDSQDSGSLCFCFRWLLIWFKREFPFPDVLRL
WEVLWTGLPGPNLHLLVACAILDMERDTLMLSGFGSNEILKHINELTMKLSVEDVLTRAEALHRQLTACPELPHNVQEILGLAPPAEPHS

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SIN3B-TBC1D17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000248054+16191_308953.01131.0CRY1
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000379803+17201_308985.01163.0CRY1
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000248054+1619284_540953.01131.0NCOR1
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000379803+1720284_540985.01163.0NCOR1
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000248054+161959_105953.01131.0REST
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000379803+172059_105985.01163.0REST
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000248054+1619392_591953.01131.0SUDS3 and HDAC1
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000379803+1720392_591985.01163.0SUDS3 and HDAC1


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000596802+181_3080354.0CRY1
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000596802+18284_5400354.0NCOR1
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000596802+1859_1050354.0REST
HgeneSIN3Bchr19:16987389chr19:50383536ENST00000596802+18392_5910354.0SUDS3 and HDAC1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SIN3B-TBC1D17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SIN3B-TBC1D17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource