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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SIPA1-FRMD8 (FusionGDB2 ID:81933)

Fusion Gene Summary for SIPA1-FRMD8

check button Fusion gene summary
Fusion gene informationFusion gene name: SIPA1-FRMD8
Fusion gene ID: 81933
HgeneTgene
Gene symbol

SIPA1

FRMD8

Gene ID

6494

83786

Gene namesignal-induced proliferation-associated 1FERM domain containing 8
SynonymsSPA1FKSG44|iTAP
Cytomap

11q13.1

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionsignal-induced proliferation-associated protein 1GTPase-activating protein Spa-1p130 SPA-1signal-induced proliferation-associated gene 1sipa-1FERM domain-containing protein 8band4.1 inhibitor LRP interactorbiliiRhom Tail-Associated Protein
Modification date2020031320200313
UniProtAcc.

Q9BZ67

Ensembl transtripts involved in fusion geneENST00000394224, ENST00000394227, 
ENST00000527525, ENST00000534313, 
ENST00000355991, ENST00000416776, 
ENST00000531296, ENST00000317568, 
Fusion gene scores* DoF score4 X 4 X 4=6410 X 11 X 10=1100
# samples 518
** MAII scorelog2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/1100*10)=-2.61143471208235
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SIPA1 [Title/Abstract] AND FRMD8 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSIPA1(65412600)-FRMD8(65178713), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFRMD8

GO:1904469

positive regulation of tumor necrosis factor secretion

29897333


check buttonFusion gene breakpoints across SIPA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FRMD8 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-DS-A1O9-01ASIPA1chr11

65412600

-FRMD8chr11

65178713

+
ChimerDB4CESCTCGA-DS-A1O9-01ASIPA1chr11

65412600

+FRMD8chr11

65178713

+
ChimerDB4CESCTCGA-DS-A1O9SIPA1chr11

65412600

+FRMD8chr11

65178713

+
ChimerDB4SKCMTCGA-FR-A3YO-06ASIPA1chr11

65410110

+FRMD8chr11

65172335

+


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Fusion Gene ORF analysis for SIPA1-FRMD8

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000394224ENST00000355991SIPA1chr11

65412600

+FRMD8chr11

65178713

+
5CDS-intronENST00000394224ENST00000355991SIPA1chr11

65410110

+FRMD8chr11

65172335

+
5CDS-intronENST00000394224ENST00000416776SIPA1chr11

65412600

+FRMD8chr11

65178713

+
5CDS-intronENST00000394224ENST00000416776SIPA1chr11

65410110

+FRMD8chr11

65172335

+
5CDS-intronENST00000394224ENST00000531296SIPA1chr11

65412600

+FRMD8chr11

65178713

+
5CDS-intronENST00000394224ENST00000531296SIPA1chr11

65410110

+FRMD8chr11

65172335

+
5CDS-intronENST00000394227ENST00000355991SIPA1chr11

65412600

+FRMD8chr11

65178713

+
5CDS-intronENST00000394227ENST00000355991SIPA1chr11

65410110

+FRMD8chr11

65172335

+
5CDS-intronENST00000394227ENST00000416776SIPA1chr11

65412600

+FRMD8chr11

65178713

+
5CDS-intronENST00000394227ENST00000416776SIPA1chr11

65410110

+FRMD8chr11

65172335

+
5CDS-intronENST00000394227ENST00000531296SIPA1chr11

65412600

+FRMD8chr11

65178713

+
5CDS-intronENST00000394227ENST00000531296SIPA1chr11

65410110

+FRMD8chr11

65172335

+
5CDS-intronENST00000527525ENST00000355991SIPA1chr11

65412600

+FRMD8chr11

65178713

+
5CDS-intronENST00000527525ENST00000355991SIPA1chr11

65410110

+FRMD8chr11

65172335

+
5CDS-intronENST00000527525ENST00000416776SIPA1chr11

65412600

+FRMD8chr11

65178713

+
5CDS-intronENST00000527525ENST00000416776SIPA1chr11

65410110

+FRMD8chr11

65172335

+
5CDS-intronENST00000527525ENST00000531296SIPA1chr11

65412600

+FRMD8chr11

65178713

+
5CDS-intronENST00000527525ENST00000531296SIPA1chr11

65410110

+FRMD8chr11

65172335

+
5CDS-intronENST00000534313ENST00000355991SIPA1chr11

65412600

+FRMD8chr11

65178713

+
5CDS-intronENST00000534313ENST00000355991SIPA1chr11

65410110

+FRMD8chr11

65172335

+
5CDS-intronENST00000534313ENST00000416776SIPA1chr11

65412600

+FRMD8chr11

65178713

+
5CDS-intronENST00000534313ENST00000416776SIPA1chr11

65410110

+FRMD8chr11

65172335

+
5CDS-intronENST00000534313ENST00000531296SIPA1chr11

65412600

+FRMD8chr11

65178713

+
5CDS-intronENST00000534313ENST00000531296SIPA1chr11

65410110

+FRMD8chr11

65172335

+
In-frameENST00000394224ENST00000317568SIPA1chr11

65412600

+FRMD8chr11

65178713

+
In-frameENST00000394224ENST00000317568SIPA1chr11

65410110

+FRMD8chr11

65172335

+
In-frameENST00000394227ENST00000317568SIPA1chr11

65412600

+FRMD8chr11

65178713

+
In-frameENST00000394227ENST00000317568SIPA1chr11

65410110

+FRMD8chr11

65172335

+
In-frameENST00000527525ENST00000317568SIPA1chr11

65412600

+FRMD8chr11

65178713

+
In-frameENST00000527525ENST00000317568SIPA1chr11

65410110

+FRMD8chr11

65172335

+
In-frameENST00000534313ENST00000317568SIPA1chr11

65412600

+FRMD8chr11

65178713

+
In-frameENST00000534313ENST00000317568SIPA1chr11

65410110

+FRMD8chr11

65172335

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000534313SIPA1chr1165412600+ENST00000317568FRMD8chr1165178713+362013361771454425
ENST00000527525SIPA1chr1165412600+ENST00000317568FRMD8chr1165178713+369014062471524425
ENST00000394224SIPA1chr1165412600+ENST00000317568FRMD8chr1165178713+373914552961573425
ENST00000394227SIPA1chr1165412600+ENST00000317568FRMD8chr1165178713+35371253941371425
ENST00000534313SIPA1chr1165410110+ENST00000317568FRMD8chr1165172335+365011611771484435
ENST00000527525SIPA1chr1165410110+ENST00000317568FRMD8chr1165172335+372012312471554435
ENST00000394224SIPA1chr1165410110+ENST00000317568FRMD8chr1165172335+376912802961603435
ENST00000394227SIPA1chr1165410110+ENST00000317568FRMD8chr1165172335+35671078941401435

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000534313ENST00000317568SIPA1chr1165412600+FRMD8chr1165178713+0.137194280.8628057
ENST00000527525ENST00000317568SIPA1chr1165412600+FRMD8chr1165178713+0.143963580.8560364
ENST00000394224ENST00000317568SIPA1chr1165412600+FRMD8chr1165178713+0.133126480.86687356
ENST00000394227ENST00000317568SIPA1chr1165412600+FRMD8chr1165178713+0.13559610.86440396
ENST00000534313ENST00000317568SIPA1chr1165410110+FRMD8chr1165172335+0.15168460.8483154
ENST00000527525ENST00000317568SIPA1chr1165410110+FRMD8chr1165172335+0.162087250.8379128
ENST00000394224ENST00000317568SIPA1chr1165410110+FRMD8chr1165172335+0.149168370.8508317
ENST00000394227ENST00000317568SIPA1chr1165410110+FRMD8chr1165172335+0.152039480.84796053

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Fusion Genomic Features for SIPA1-FRMD8


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SIPA1chr1165410110+FRMD8chr1165172334+0.0013760270.99862397
SIPA1chr1165412600+FRMD8chr1165178712+7.37E-050.9999263
SIPA1chr1165412600+FRMD8chr1165178712+7.37E-050.9999263
SIPA1chr1165410110+FRMD8chr1165172334+0.0013760270.99862397
SIPA1chr1165412600+FRMD8chr1165178712+7.37E-050.9999263
SIPA1chr1165412600+FRMD8chr1165178712+7.37E-050.9999263

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SIPA1-FRMD8


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:65412600/chr11:65178713)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FRMD8

Q9BZ67

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface (PubMed:29897333, PubMed:29897336). Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 (PubMed:19572019). {ECO:0000269|PubMed:19572019, ECO:0000269|PubMed:29897333, ECO:0000269|PubMed:29897336}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSIPA1chr11:65410110chr11:65172335ENST00000394224+416972_10343281043.0Coiled coilOntology_term=ECO:0000255
HgeneSIPA1chr11:65410110chr11:65172335ENST00000534313+416972_10343281043.0Coiled coilOntology_term=ECO:0000255
HgeneSIPA1chr11:65412600chr11:65178713ENST00000394224+516972_10343861043.0Coiled coilOntology_term=ECO:0000255
HgeneSIPA1chr11:65412600chr11:65178713ENST00000534313+516972_10343861043.0Coiled coilOntology_term=ECO:0000255
HgeneSIPA1chr11:65410110chr11:65172335ENST00000394224+416321_5393281043.0DomainRap-GAP
HgeneSIPA1chr11:65410110chr11:65172335ENST00000394224+416687_7633281043.0DomainPDZ
HgeneSIPA1chr11:65410110chr11:65172335ENST00000534313+416321_5393281043.0DomainRap-GAP
HgeneSIPA1chr11:65410110chr11:65172335ENST00000534313+416687_7633281043.0DomainPDZ
HgeneSIPA1chr11:65412600chr11:65178713ENST00000394224+516321_5393861043.0DomainRap-GAP
HgeneSIPA1chr11:65412600chr11:65178713ENST00000394224+516687_7633861043.0DomainPDZ
HgeneSIPA1chr11:65412600chr11:65178713ENST00000534313+516321_5393861043.0DomainRap-GAP
HgeneSIPA1chr11:65412600chr11:65178713ENST00000534313+516687_7633861043.0DomainPDZ
TgeneFRMD8chr11:65410110chr11:65172335ENST0000031756881130_376357465.0DomainFERM
TgeneFRMD8chr11:65410110chr11:65172335ENST0000035599171030_376301409.0DomainFERM
TgeneFRMD8chr11:65412600chr11:65178713ENST0000031756891130_376425465.0DomainFERM
TgeneFRMD8chr11:65412600chr11:65178713ENST0000035599181030_376369409.0DomainFERM


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Fusion Gene Sequence for SIPA1-FRMD8


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>81933_81933_1_SIPA1-FRMD8_SIPA1_chr11_65410110_ENST00000394224_FRMD8_chr11_65172335_ENST00000317568_length(transcript)=3769nt_BP=1280nt
GGCAGGGTGACTGGGGTCCCATGACAGCTGCTGTGACCCCAGCACCTTCCTCAGGATGTGGGGGCCTGGCAGAGGGCTGGGCCCACAGTT
GGGGCTACTTCCTGTGCTGAAGGAAGTCCTCTTGCCATTCCTGCTGCCCTGCCGCTGCCTCCCTGGGAACCCATGTGTCCTTGTGGCCCC
TCTGAGCAGCCCCCTCCTCCTTCAGGGCAGGAACTGCTGCCACAACCTCAGGCTGGGCACCAAACACCCGTGCCCGCCAATGCGGCCCAG
CCCCCGGAGAGTCAGGCCCACAGAGCATGCCCATGTGGGCCGGCGGTGTGGGGAGCCCTCGGCGGGGCATGGCCCCTGCGTCCACAGATG
ACCTCTTTGCCCGCAAGCTGCGCCAGCCAGCAAGGCCCCCGCTGACACCGCACACCTTCGAGCCGAGGCCAGTCCGGGGCCCACTCCTGC
GCAGCGGCAGCGATGCAGGCGAGGCCAGGCCCCCCACGCCAGCCAGCCCCCGTGCCCGTGCCCACAGCCACGAAGAGGCCAGCCGACCTG
CAGCCACTTCCACCCGGCTCTTCACTGACCCGCTGGCACTGCTGGGGCTGCCAGCAGAGGAACCAGAGCCTGCCTTCCCACCAGTGCTTG
AGCCTCGATGGTTTGCCCACTATGACGTGCAAAGCCTGCTCTTTGATTGGGCTCCGAGGTCTCAGGGGATGGGGAGCCACTCAGAGGCCA
GCTCTGGGACCCTGGCTTCAGCCGAGGACCAGGCTGCCAGCTCGGACCTGCTGCATGGGGCACCTGGCTTTGTGTGTGAGCTCGGGGGTG
AGGGTGAGCTAGGCCTGGGTGGACCAGCATCCCCACCTGTGCCCCCTGCACTGCCCAACGCGGCCGTGTCCATCCTGGAGGAGCCACAGA
ACCGAACCTCGGCCTACAGCCTGGAGCACGCAGACCTGGGTGCTGGCTACTACCGCAAATACTTCTATGGCAAAGAACATCAGAACTTCT
TCGGGATGGACGAGTCGCTGGGCCCGGTGGCAGTGAGCCTGCGGCGGGAGGAGAAGGAGGGCAGCGGAGGGGGCACCCTGCACAGCTACC
GCGTCATCGTGCGGACCACGCAGCTCCGGACACTCCGTGGCACCATCTCGGAGGACGCGCTGCCGCCGGGGCCCCCACGGGGTCTGTCCC
CAAGGAAACTTCTGGAGCACGTGGCGCCGCAGCTGAGCCCCAGCTGCCTGCGCCTGGGCTCAGCTTCACCCAAGGTACCACGGACGCTGC
TCACACTGGATGAGCAAGTGGCCGAACTGATGAGCAGTCTCATTGAGTACTGCATCGAACTGAGCCAGGCGGCGGAGCCCGCAGGCCCCC
AGGACAGTGCGACTGGCTCGCCCTCGGACCCCAGCTCCTCACTGGCTCCTGTTCAGCGCCCCAAGCTGCGGAGGCAGGGCAGTGTGGTGT
CCAGCCGGATCCAGCATCTCTCCACCATCGACTACGTGGAGGACGGCAAGGGGATCAGGCGAGTGAAGCCGAAGCGCACCACATCCTTCT
TCAGCCGGCAGCTGTCCTTGGGCCAGGGGAGCTACACCGTGGTGCAGCCCGGCGACAGCCTGGAGCAGGGCTGAGGACGCTGCACCCGGC
AGGAGGAGGGCGACTGGGGGCCCTGGCCCGGCACTGTCCTCCTGAGGGGCAGGCGCCGGCTGCAACAGTCTCATGGGTCACCACGTGGGG
AGGGCTGCCTCAGCAGGTTTCTCAGACCACGGAGAAGTGACTTTTGGGCCCGGGGCCATGCCCGGGCTGTGCAAAGCTGGCCAGGGCCTC
CTGTAGGGCTCCTCTGCAGCCTGCCCTCCCTTCCCCCGGATGCTGGGCCCTGCTGCTCTCTCAGGACCATCCGATCAAGCTGCAGCTGCC
ACCCTCACCTAGAAACATGCCTTTGTGCCCACCTCAAGATGGGCAGTGTCCCTGTTCTGAAGTGCCCAGTGGCAGCTCCAGTGGTAGAGG
ACCAAGGATTGAGGTTTGGGACCTGAAGCTCCAGTGTGTGCCTTTGGCCTCTTCCCTGGACTTGGGTGACCAGTCTCCGTCTTCCTCCTG
CTAGTGCTCCACCCCCCGGACTTGGATGACCAGTTTCCCACCTTCCTCCTGCTGGTGCTCCATCCCCCAATACCAGGCTGGGCCACCACT
CTGAGGAGGGTAGGAGGGGCCTCCCTGGATTGAACCGGGACAGAAACACGGTGAGGGCCCCCACCACACCTCCCTGGTTGAATCAGGAAT
GGAGGGAGCCAGGCAGGGCCCTACCTGGGGTCCTGTGCCCCTCGTTCTGGTCTCCTTTGCAGGCACGAGATACCAGAAAGAGCATGCCTT
TCTGATAGCCTTTGGTGATGTCACTGCTGGGAGGTGGCTATCCTGTGGACCACCTGGCCTCCAGACCCACACTCACAGTCTGTGAAAAAC
TGAAAATCCCCTGGTGGGCACTCCCTGGAGCCCAAGCAGCTCCCCTAGGGGACTGACCGGACCTGACCTCCCCTCCCTGTGTCTGGGTCT
TCAGGTTTTAGTTTGGTCTTTGTTCATCTGAGTTGTGCTGGGGCAACGCCAGGAAGTGCCCTGGGTACCTCTGCTGTGCGCTCCTTCCCA
GGTGGCGCCATGGATTCCTCTGGGGGCTGGCGCATGCCCAGGAAAGCCTGGGCCACACGGGACACTCTCTTCTTTATCGAGGACACTTGG
AAAGGTGACTGATATGGGTGCTTGGCTTCTCTGGTCCCAGCTTGCCCTCCGGGGAGCAGGGGCTCTGTCTTGTCCCAGATGAGCTGAGAG
CCCCTGAGAGGAGGGCTTTCCCAGCCCTGGGACCCTCCGAGGTGGGTGTGCGGGTCTCACAGGTGCTTCCTGGGACTTCCTGTGGCTGCA
CAGGGCTTGGCTTTGTCTTCGTTCCCGGTGGAAAACCGTGGGAGAGGAAGCTTGGGCCTCTACTCCAAGTATCAGAGCCTGTTCACCCTC
CTCCCTTTGGTAGCTTGTGAATGTGCCAGGTGTTTCGAGGTAGGCTTGCCTTCTGGCAGCATGGACTTTGTTAAAATAATAGGCGGAAAG
AAGAGGCCTGGGAAGGGCCCCCAGTCTTTTGGAATGTCCTGGTCACAGGGTCATGTCAGCTGCCAGTTCTCGTCTCCCGTCCTGGAGTTG
CTCGGTCTTGCGGAGCTGCCCGCCTGCCTGTTCTGGCGGCTCCAGCGCAGGCTGTCCCTGCTGCTTTGATTCCAGGTGATTTTATTTTTT
TTATTTTTTTATTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCAGGAGTGCAGTGGCGCATCTCGGCTCACTGCAACCTCTGTCT
CAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCATGCCACCAGGCCCCGCTGATTTTTGTATTTTTAGTAGAGA
TAGGGTTTCACCATGTTGGTCAGGCTGGTCGTGAACTCCTGACCTCATGATCTGCCCGCCTCAACCTCCCAAAGTGCTGGGATTATAGGC
GTGAGCCACCGCCCCCAGCTGATTCCAGGCGAATTCTTCTCTGATGGGCGGGCGAGGGTGTGTTCGTGTGATGGGTTGGAGTGTGTGTGT
CTGAGTACACAGATGATGTGTTTTCCCTTCAGCTTCTTACGTTTTCTGAGCATCCATTGTGCCTTAACATTTTCTGCTTGTCCTTTGGGA

>81933_81933_1_SIPA1-FRMD8_SIPA1_chr11_65410110_ENST00000394224_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=435AA_BP=303
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT
DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL
RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVAELMSSLIEYCIELSQAAEPAGPQDSATGSPS

--------------------------------------------------------------
>81933_81933_2_SIPA1-FRMD8_SIPA1_chr11_65410110_ENST00000394227_FRMD8_chr11_65172335_ENST00000317568_length(transcript)=3567nt_BP=1078nt
CAGGGCAGGAACTGCTGCCACAACCTCAGGCTGGGCACCAAACACCCGTGCCCGCCAATGCGGCCCAGCCCCCGGAGAGTCAGGCCCACA
GAGCATGCCCATGTGGGCCGGCGGTGTGGGGAGCCCTCGGCGGGGCATGGCCCCTGCGTCCACAGATGACCTCTTTGCCCGCAAGCTGCG
CCAGCCAGCAAGGCCCCCGCTGACACCGCACACCTTCGAGCCGAGGCCAGTCCGGGGCCCACTCCTGCGCAGCGGCAGCGATGCAGGCGA
GGCCAGGCCCCCCACGCCAGCCAGCCCCCGTGCCCGTGCCCACAGCCACGAAGAGGCCAGCCGACCTGCAGCCACTTCCACCCGGCTCTT
CACTGACCCGCTGGCACTGCTGGGGCTGCCAGCAGAGGAACCAGAGCCTGCCTTCCCACCAGTGCTTGAGCCTCGATGGTTTGCCCACTA
TGACGTGCAAAGCCTGCTCTTTGATTGGGCTCCGAGGTCTCAGGGGATGGGGAGCCACTCAGAGGCCAGCTCTGGGACCCTGGCTTCAGC
CGAGGACCAGGCTGCCAGCTCGGACCTGCTGCATGGGGCACCTGGCTTTGTGTGTGAGCTCGGGGGTGAGGGTGAGCTAGGCCTGGGTGG
ACCAGCATCCCCACCTGTGCCCCCTGCACTGCCCAACGCGGCCGTGTCCATCCTGGAGGAGCCACAGAACCGAACCTCGGCCTACAGCCT
GGAGCACGCAGACCTGGGTGCTGGCTACTACCGCAAATACTTCTATGGCAAAGAACATCAGAACTTCTTCGGGATGGACGAGTCGCTGGG
CCCGGTGGCAGTGAGCCTGCGGCGGGAGGAGAAGGAGGGCAGCGGAGGGGGCACCCTGCACAGCTACCGCGTCATCGTGCGGACCACGCA
GCTCCGGACACTCCGTGGCACCATCTCGGAGGACGCGCTGCCGCCGGGGCCCCCACGGGGTCTGTCCCCAAGGAAACTTCTGGAGCACGT
GGCGCCGCAGCTGAGCCCCAGCTGCCTGCGCCTGGGCTCAGCTTCACCCAAGGTACCACGGACGCTGCTCACACTGGATGAGCAAGTGGC
CGAACTGATGAGCAGTCTCATTGAGTACTGCATCGAACTGAGCCAGGCGGCGGAGCCCGCAGGCCCCCAGGACAGTGCGACTGGCTCGCC
CTCGGACCCCAGCTCCTCACTGGCTCCTGTTCAGCGCCCCAAGCTGCGGAGGCAGGGCAGTGTGGTGTCCAGCCGGATCCAGCATCTCTC
CACCATCGACTACGTGGAGGACGGCAAGGGGATCAGGCGAGTGAAGCCGAAGCGCACCACATCCTTCTTCAGCCGGCAGCTGTCCTTGGG
CCAGGGGAGCTACACCGTGGTGCAGCCCGGCGACAGCCTGGAGCAGGGCTGAGGACGCTGCACCCGGCAGGAGGAGGGCGACTGGGGGCC
CTGGCCCGGCACTGTCCTCCTGAGGGGCAGGCGCCGGCTGCAACAGTCTCATGGGTCACCACGTGGGGAGGGCTGCCTCAGCAGGTTTCT
CAGACCACGGAGAAGTGACTTTTGGGCCCGGGGCCATGCCCGGGCTGTGCAAAGCTGGCCAGGGCCTCCTGTAGGGCTCCTCTGCAGCCT
GCCCTCCCTTCCCCCGGATGCTGGGCCCTGCTGCTCTCTCAGGACCATCCGATCAAGCTGCAGCTGCCACCCTCACCTAGAAACATGCCT
TTGTGCCCACCTCAAGATGGGCAGTGTCCCTGTTCTGAAGTGCCCAGTGGCAGCTCCAGTGGTAGAGGACCAAGGATTGAGGTTTGGGAC
CTGAAGCTCCAGTGTGTGCCTTTGGCCTCTTCCCTGGACTTGGGTGACCAGTCTCCGTCTTCCTCCTGCTAGTGCTCCACCCCCCGGACT
TGGATGACCAGTTTCCCACCTTCCTCCTGCTGGTGCTCCATCCCCCAATACCAGGCTGGGCCACCACTCTGAGGAGGGTAGGAGGGGCCT
CCCTGGATTGAACCGGGACAGAAACACGGTGAGGGCCCCCACCACACCTCCCTGGTTGAATCAGGAATGGAGGGAGCCAGGCAGGGCCCT
ACCTGGGGTCCTGTGCCCCTCGTTCTGGTCTCCTTTGCAGGCACGAGATACCAGAAAGAGCATGCCTTTCTGATAGCCTTTGGTGATGTC
ACTGCTGGGAGGTGGCTATCCTGTGGACCACCTGGCCTCCAGACCCACACTCACAGTCTGTGAAAAACTGAAAATCCCCTGGTGGGCACT
CCCTGGAGCCCAAGCAGCTCCCCTAGGGGACTGACCGGACCTGACCTCCCCTCCCTGTGTCTGGGTCTTCAGGTTTTAGTTTGGTCTTTG
TTCATCTGAGTTGTGCTGGGGCAACGCCAGGAAGTGCCCTGGGTACCTCTGCTGTGCGCTCCTTCCCAGGTGGCGCCATGGATTCCTCTG
GGGGCTGGCGCATGCCCAGGAAAGCCTGGGCCACACGGGACACTCTCTTCTTTATCGAGGACACTTGGAAAGGTGACTGATATGGGTGCT
TGGCTTCTCTGGTCCCAGCTTGCCCTCCGGGGAGCAGGGGCTCTGTCTTGTCCCAGATGAGCTGAGAGCCCCTGAGAGGAGGGCTTTCCC
AGCCCTGGGACCCTCCGAGGTGGGTGTGCGGGTCTCACAGGTGCTTCCTGGGACTTCCTGTGGCTGCACAGGGCTTGGCTTTGTCTTCGT
TCCCGGTGGAAAACCGTGGGAGAGGAAGCTTGGGCCTCTACTCCAAGTATCAGAGCCTGTTCACCCTCCTCCCTTTGGTAGCTTGTGAAT
GTGCCAGGTGTTTCGAGGTAGGCTTGCCTTCTGGCAGCATGGACTTTGTTAAAATAATAGGCGGAAAGAAGAGGCCTGGGAAGGGCCCCC
AGTCTTTTGGAATGTCCTGGTCACAGGGTCATGTCAGCTGCCAGTTCTCGTCTCCCGTCCTGGAGTTGCTCGGTCTTGCGGAGCTGCCCG
CCTGCCTGTTCTGGCGGCTCCAGCGCAGGCTGTCCCTGCTGCTTTGATTCCAGGTGATTTTATTTTTTTTATTTTTTTATTTTTTTTGAG
ACGGAGTCTTGCTCTGTTGCCCAGGCAGGAGTGCAGTGGCGCATCTCGGCTCACTGCAACCTCTGTCTCAAGCGATTCTCCTGCCTCAGC
CTCCTGAGTAGCTGGGATTACAGGTGCATGCCACCAGGCCCCGCTGATTTTTGTATTTTTAGTAGAGATAGGGTTTCACCATGTTGGTCA
GGCTGGTCGTGAACTCCTGACCTCATGATCTGCCCGCCTCAACCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCACCGCCCCCAGCTGA
TTCCAGGCGAATTCTTCTCTGATGGGCGGGCGAGGGTGTGTTCGTGTGATGGGTTGGAGTGTGTGTGTCTGAGTACACAGATGATGTGTT
TTCCCTTCAGCTTCTTACGTTTTCTGAGCATCCATTGTGCCTTAACATTTTCTGCTTGTCCTTTGGGACAAAGCAGTATTTTACTCATTC

>81933_81933_2_SIPA1-FRMD8_SIPA1_chr11_65410110_ENST00000394227_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=435AA_BP=303
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT
DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL
RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVAELMSSLIEYCIELSQAAEPAGPQDSATGSPS

--------------------------------------------------------------
>81933_81933_3_SIPA1-FRMD8_SIPA1_chr11_65410110_ENST00000527525_FRMD8_chr11_65172335_ENST00000317568_length(transcript)=3720nt_BP=1231nt
AGGTGCAGCCCTGCTTAGGGCCTGGAGATGGGCAGACCCAGGCTCACATCCTAGCTCTGACACGGAATTGCTTCAGGCAAGAGCATCTCC
TCTGGACCTCATCTGACCATCTGTCACATGGGGTTCAGACCTCCCTGTCTGCATCAGTGAGACCAGGGCAGGAACTGCTGCCACAACCTC
AGGCTGGGCACCAAACACCCGTGCCCGCCAATGCGGCCCAGCCCCCGGAGAGTCAGGCCCACAGAGCATGCCCATGTGGGCCGGCGGTGT
GGGGAGCCCTCGGCGGGGCATGGCCCCTGCGTCCACAGATGACCTCTTTGCCCGCAAGCTGCGCCAGCCAGCAAGGCCCCCGCTGACACC
GCACACCTTCGAGCCGAGGCCAGTCCGGGGCCCACTCCTGCGCAGCGGCAGCGATGCAGGCGAGGCCAGGCCCCCCACGCCAGCCAGCCC
CCGTGCCCGTGCCCACAGCCACGAAGAGGCCAGCCGACCTGCAGCCACTTCCACCCGGCTCTTCACTGACCCGCTGGCACTGCTGGGGCT
GCCAGCAGAGGAACCAGAGCCTGCCTTCCCACCAGTGCTTGAGCCTCGATGGTTTGCCCACTATGACGTGCAAAGCCTGCTCTTTGATTG
GGCTCCGAGGTCTCAGGGGATGGGGAGCCACTCAGAGGCCAGCTCTGGGACCCTGGCTTCAGCCGAGGACCAGGCTGCCAGCTCGGACCT
GCTGCATGGGGCACCTGGCTTTGTGTGTGAGCTCGGGGGTGAGGGTGAGCTAGGCCTGGGTGGACCAGCATCCCCACCTGTGCCCCCTGC
ACTGCCCAACGCGGCCGTGTCCATCCTGGAGGAGCCACAGAACCGAACCTCGGCCTACAGCCTGGAGCACGCAGACCTGGGTGCTGGCTA
CTACCGCAAATACTTCTATGGCAAAGAACATCAGAACTTCTTCGGGATGGACGAGTCGCTGGGCCCGGTGGCAGTGAGCCTGCGGCGGGA
GGAGAAGGAGGGCAGCGGAGGGGGCACCCTGCACAGCTACCGCGTCATCGTGCGGACCACGCAGCTCCGGACACTCCGTGGCACCATCTC
GGAGGACGCGCTGCCGCCGGGGCCCCCACGGGGTCTGTCCCCAAGGAAACTTCTGGAGCACGTGGCGCCGCAGCTGAGCCCCAGCTGCCT
GCGCCTGGGCTCAGCTTCACCCAAGGTACCACGGACGCTGCTCACACTGGATGAGCAAGTGGCCGAACTGATGAGCAGTCTCATTGAGTA
CTGCATCGAACTGAGCCAGGCGGCGGAGCCCGCAGGCCCCCAGGACAGTGCGACTGGCTCGCCCTCGGACCCCAGCTCCTCACTGGCTCC
TGTTCAGCGCCCCAAGCTGCGGAGGCAGGGCAGTGTGGTGTCCAGCCGGATCCAGCATCTCTCCACCATCGACTACGTGGAGGACGGCAA
GGGGATCAGGCGAGTGAAGCCGAAGCGCACCACATCCTTCTTCAGCCGGCAGCTGTCCTTGGGCCAGGGGAGCTACACCGTGGTGCAGCC
CGGCGACAGCCTGGAGCAGGGCTGAGGACGCTGCACCCGGCAGGAGGAGGGCGACTGGGGGCCCTGGCCCGGCACTGTCCTCCTGAGGGG
CAGGCGCCGGCTGCAACAGTCTCATGGGTCACCACGTGGGGAGGGCTGCCTCAGCAGGTTTCTCAGACCACGGAGAAGTGACTTTTGGGC
CCGGGGCCATGCCCGGGCTGTGCAAAGCTGGCCAGGGCCTCCTGTAGGGCTCCTCTGCAGCCTGCCCTCCCTTCCCCCGGATGCTGGGCC
CTGCTGCTCTCTCAGGACCATCCGATCAAGCTGCAGCTGCCACCCTCACCTAGAAACATGCCTTTGTGCCCACCTCAAGATGGGCAGTGT
CCCTGTTCTGAAGTGCCCAGTGGCAGCTCCAGTGGTAGAGGACCAAGGATTGAGGTTTGGGACCTGAAGCTCCAGTGTGTGCCTTTGGCC
TCTTCCCTGGACTTGGGTGACCAGTCTCCGTCTTCCTCCTGCTAGTGCTCCACCCCCCGGACTTGGATGACCAGTTTCCCACCTTCCTCC
TGCTGGTGCTCCATCCCCCAATACCAGGCTGGGCCACCACTCTGAGGAGGGTAGGAGGGGCCTCCCTGGATTGAACCGGGACAGAAACAC
GGTGAGGGCCCCCACCACACCTCCCTGGTTGAATCAGGAATGGAGGGAGCCAGGCAGGGCCCTACCTGGGGTCCTGTGCCCCTCGTTCTG
GTCTCCTTTGCAGGCACGAGATACCAGAAAGAGCATGCCTTTCTGATAGCCTTTGGTGATGTCACTGCTGGGAGGTGGCTATCCTGTGGA
CCACCTGGCCTCCAGACCCACACTCACAGTCTGTGAAAAACTGAAAATCCCCTGGTGGGCACTCCCTGGAGCCCAAGCAGCTCCCCTAGG
GGACTGACCGGACCTGACCTCCCCTCCCTGTGTCTGGGTCTTCAGGTTTTAGTTTGGTCTTTGTTCATCTGAGTTGTGCTGGGGCAACGC
CAGGAAGTGCCCTGGGTACCTCTGCTGTGCGCTCCTTCCCAGGTGGCGCCATGGATTCCTCTGGGGGCTGGCGCATGCCCAGGAAAGCCT
GGGCCACACGGGACACTCTCTTCTTTATCGAGGACACTTGGAAAGGTGACTGATATGGGTGCTTGGCTTCTCTGGTCCCAGCTTGCCCTC
CGGGGAGCAGGGGCTCTGTCTTGTCCCAGATGAGCTGAGAGCCCCTGAGAGGAGGGCTTTCCCAGCCCTGGGACCCTCCGAGGTGGGTGT
GCGGGTCTCACAGGTGCTTCCTGGGACTTCCTGTGGCTGCACAGGGCTTGGCTTTGTCTTCGTTCCCGGTGGAAAACCGTGGGAGAGGAA
GCTTGGGCCTCTACTCCAAGTATCAGAGCCTGTTCACCCTCCTCCCTTTGGTAGCTTGTGAATGTGCCAGGTGTTTCGAGGTAGGCTTGC
CTTCTGGCAGCATGGACTTTGTTAAAATAATAGGCGGAAAGAAGAGGCCTGGGAAGGGCCCCCAGTCTTTTGGAATGTCCTGGTCACAGG
GTCATGTCAGCTGCCAGTTCTCGTCTCCCGTCCTGGAGTTGCTCGGTCTTGCGGAGCTGCCCGCCTGCCTGTTCTGGCGGCTCCAGCGCA
GGCTGTCCCTGCTGCTTTGATTCCAGGTGATTTTATTTTTTTTATTTTTTTATTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCA
GGAGTGCAGTGGCGCATCTCGGCTCACTGCAACCTCTGTCTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGC
ATGCCACCAGGCCCCGCTGATTTTTGTATTTTTAGTAGAGATAGGGTTTCACCATGTTGGTCAGGCTGGTCGTGAACTCCTGACCTCATG
ATCTGCCCGCCTCAACCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCACCGCCCCCAGCTGATTCCAGGCGAATTCTTCTCTGATGGGC
GGGCGAGGGTGTGTTCGTGTGATGGGTTGGAGTGTGTGTGTCTGAGTACACAGATGATGTGTTTTCCCTTCAGCTTCTTACGTTTTCTGA
GCATCCATTGTGCCTTAACATTTTCTGCTTGTCCTTTGGGACAAAGCAGTATTTTACTCATTCTTTGAATGTTCTCATTCTTTTGTATCA

>81933_81933_3_SIPA1-FRMD8_SIPA1_chr11_65410110_ENST00000527525_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=435AA_BP=303
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT
DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL
RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVAELMSSLIEYCIELSQAAEPAGPQDSATGSPS

--------------------------------------------------------------
>81933_81933_4_SIPA1-FRMD8_SIPA1_chr11_65410110_ENST00000534313_FRMD8_chr11_65172335_ENST00000317568_length(transcript)=3650nt_BP=1161nt
AGGCGGAGCCGGCGCCGGGAGCGGTAGCGGGAGAGCGGCAGCGGGACCCCAGCGCGGGCGGCGGCGGCTGGGCGGGAGCCCCAGAGGGCA
GGAACTGCTGCCACAACCTCAGGCTGGGCACCAAACACCCGTGCCCGCCAATGCGGCCCAGCCCCCGGAGAGTCAGGCCCACAGAGCATG
CCCATGTGGGCCGGCGGTGTGGGGAGCCCTCGGCGGGGCATGGCCCCTGCGTCCACAGATGACCTCTTTGCCCGCAAGCTGCGCCAGCCA
GCAAGGCCCCCGCTGACACCGCACACCTTCGAGCCGAGGCCAGTCCGGGGCCCACTCCTGCGCAGCGGCAGCGATGCAGGCGAGGCCAGG
CCCCCCACGCCAGCCAGCCCCCGTGCCCGTGCCCACAGCCACGAAGAGGCCAGCCGACCTGCAGCCACTTCCACCCGGCTCTTCACTGAC
CCGCTGGCACTGCTGGGGCTGCCAGCAGAGGAACCAGAGCCTGCCTTCCCACCAGTGCTTGAGCCTCGATGGTTTGCCCACTATGACGTG
CAAAGCCTGCTCTTTGATTGGGCTCCGAGGTCTCAGGGGATGGGGAGCCACTCAGAGGCCAGCTCTGGGACCCTGGCTTCAGCCGAGGAC
CAGGCTGCCAGCTCGGACCTGCTGCATGGGGCACCTGGCTTTGTGTGTGAGCTCGGGGGTGAGGGTGAGCTAGGCCTGGGTGGACCAGCA
TCCCCACCTGTGCCCCCTGCACTGCCCAACGCGGCCGTGTCCATCCTGGAGGAGCCACAGAACCGAACCTCGGCCTACAGCCTGGAGCAC
GCAGACCTGGGTGCTGGCTACTACCGCAAATACTTCTATGGCAAAGAACATCAGAACTTCTTCGGGATGGACGAGTCGCTGGGCCCGGTG
GCAGTGAGCCTGCGGCGGGAGGAGAAGGAGGGCAGCGGAGGGGGCACCCTGCACAGCTACCGCGTCATCGTGCGGACCACGCAGCTCCGG
ACACTCCGTGGCACCATCTCGGAGGACGCGCTGCCGCCGGGGCCCCCACGGGGTCTGTCCCCAAGGAAACTTCTGGAGCACGTGGCGCCG
CAGCTGAGCCCCAGCTGCCTGCGCCTGGGCTCAGCTTCACCCAAGGTACCACGGACGCTGCTCACACTGGATGAGCAAGTGGCCGAACTG
ATGAGCAGTCTCATTGAGTACTGCATCGAACTGAGCCAGGCGGCGGAGCCCGCAGGCCCCCAGGACAGTGCGACTGGCTCGCCCTCGGAC
CCCAGCTCCTCACTGGCTCCTGTTCAGCGCCCCAAGCTGCGGAGGCAGGGCAGTGTGGTGTCCAGCCGGATCCAGCATCTCTCCACCATC
GACTACGTGGAGGACGGCAAGGGGATCAGGCGAGTGAAGCCGAAGCGCACCACATCCTTCTTCAGCCGGCAGCTGTCCTTGGGCCAGGGG
AGCTACACCGTGGTGCAGCCCGGCGACAGCCTGGAGCAGGGCTGAGGACGCTGCACCCGGCAGGAGGAGGGCGACTGGGGGCCCTGGCCC
GGCACTGTCCTCCTGAGGGGCAGGCGCCGGCTGCAACAGTCTCATGGGTCACCACGTGGGGAGGGCTGCCTCAGCAGGTTTCTCAGACCA
CGGAGAAGTGACTTTTGGGCCCGGGGCCATGCCCGGGCTGTGCAAAGCTGGCCAGGGCCTCCTGTAGGGCTCCTCTGCAGCCTGCCCTCC
CTTCCCCCGGATGCTGGGCCCTGCTGCTCTCTCAGGACCATCCGATCAAGCTGCAGCTGCCACCCTCACCTAGAAACATGCCTTTGTGCC
CACCTCAAGATGGGCAGTGTCCCTGTTCTGAAGTGCCCAGTGGCAGCTCCAGTGGTAGAGGACCAAGGATTGAGGTTTGGGACCTGAAGC
TCCAGTGTGTGCCTTTGGCCTCTTCCCTGGACTTGGGTGACCAGTCTCCGTCTTCCTCCTGCTAGTGCTCCACCCCCCGGACTTGGATGA
CCAGTTTCCCACCTTCCTCCTGCTGGTGCTCCATCCCCCAATACCAGGCTGGGCCACCACTCTGAGGAGGGTAGGAGGGGCCTCCCTGGA
TTGAACCGGGACAGAAACACGGTGAGGGCCCCCACCACACCTCCCTGGTTGAATCAGGAATGGAGGGAGCCAGGCAGGGCCCTACCTGGG
GTCCTGTGCCCCTCGTTCTGGTCTCCTTTGCAGGCACGAGATACCAGAAAGAGCATGCCTTTCTGATAGCCTTTGGTGATGTCACTGCTG
GGAGGTGGCTATCCTGTGGACCACCTGGCCTCCAGACCCACACTCACAGTCTGTGAAAAACTGAAAATCCCCTGGTGGGCACTCCCTGGA
GCCCAAGCAGCTCCCCTAGGGGACTGACCGGACCTGACCTCCCCTCCCTGTGTCTGGGTCTTCAGGTTTTAGTTTGGTCTTTGTTCATCT
GAGTTGTGCTGGGGCAACGCCAGGAAGTGCCCTGGGTACCTCTGCTGTGCGCTCCTTCCCAGGTGGCGCCATGGATTCCTCTGGGGGCTG
GCGCATGCCCAGGAAAGCCTGGGCCACACGGGACACTCTCTTCTTTATCGAGGACACTTGGAAAGGTGACTGATATGGGTGCTTGGCTTC
TCTGGTCCCAGCTTGCCCTCCGGGGAGCAGGGGCTCTGTCTTGTCCCAGATGAGCTGAGAGCCCCTGAGAGGAGGGCTTTCCCAGCCCTG
GGACCCTCCGAGGTGGGTGTGCGGGTCTCACAGGTGCTTCCTGGGACTTCCTGTGGCTGCACAGGGCTTGGCTTTGTCTTCGTTCCCGGT
GGAAAACCGTGGGAGAGGAAGCTTGGGCCTCTACTCCAAGTATCAGAGCCTGTTCACCCTCCTCCCTTTGGTAGCTTGTGAATGTGCCAG
GTGTTTCGAGGTAGGCTTGCCTTCTGGCAGCATGGACTTTGTTAAAATAATAGGCGGAAAGAAGAGGCCTGGGAAGGGCCCCCAGTCTTT
TGGAATGTCCTGGTCACAGGGTCATGTCAGCTGCCAGTTCTCGTCTCCCGTCCTGGAGTTGCTCGGTCTTGCGGAGCTGCCCGCCTGCCT
GTTCTGGCGGCTCCAGCGCAGGCTGTCCCTGCTGCTTTGATTCCAGGTGATTTTATTTTTTTTATTTTTTTATTTTTTTTGAGACGGAGT
CTTGCTCTGTTGCCCAGGCAGGAGTGCAGTGGCGCATCTCGGCTCACTGCAACCTCTGTCTCAAGCGATTCTCCTGCCTCAGCCTCCTGA
GTAGCTGGGATTACAGGTGCATGCCACCAGGCCCCGCTGATTTTTGTATTTTTAGTAGAGATAGGGTTTCACCATGTTGGTCAGGCTGGT
CGTGAACTCCTGACCTCATGATCTGCCCGCCTCAACCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCACCGCCCCCAGCTGATTCCAGG
CGAATTCTTCTCTGATGGGCGGGCGAGGGTGTGTTCGTGTGATGGGTTGGAGTGTGTGTGTCTGAGTACACAGATGATGTGTTTTCCCTT
CAGCTTCTTACGTTTTCTGAGCATCCATTGTGCCTTAACATTTTCTGCTTGTCCTTTGGGACAAAGCAGTATTTTACTCATTCTTTGAAT

>81933_81933_4_SIPA1-FRMD8_SIPA1_chr11_65410110_ENST00000534313_FRMD8_chr11_65172335_ENST00000317568_length(amino acids)=435AA_BP=303
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT
DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL
RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVAELMSSLIEYCIELSQAAEPAGPQDSATGSPS

--------------------------------------------------------------
>81933_81933_5_SIPA1-FRMD8_SIPA1_chr11_65412600_ENST00000394224_FRMD8_chr11_65178713_ENST00000317568_length(transcript)=3739nt_BP=1455nt
GGCAGGGTGACTGGGGTCCCATGACAGCTGCTGTGACCCCAGCACCTTCCTCAGGATGTGGGGGCCTGGCAGAGGGCTGGGCCCACAGTT
GGGGCTACTTCCTGTGCTGAAGGAAGTCCTCTTGCCATTCCTGCTGCCCTGCCGCTGCCTCCCTGGGAACCCATGTGTCCTTGTGGCCCC
TCTGAGCAGCCCCCTCCTCCTTCAGGGCAGGAACTGCTGCCACAACCTCAGGCTGGGCACCAAACACCCGTGCCCGCCAATGCGGCCCAG
CCCCCGGAGAGTCAGGCCCACAGAGCATGCCCATGTGGGCCGGCGGTGTGGGGAGCCCTCGGCGGGGCATGGCCCCTGCGTCCACAGATG
ACCTCTTTGCCCGCAAGCTGCGCCAGCCAGCAAGGCCCCCGCTGACACCGCACACCTTCGAGCCGAGGCCAGTCCGGGGCCCACTCCTGC
GCAGCGGCAGCGATGCAGGCGAGGCCAGGCCCCCCACGCCAGCCAGCCCCCGTGCCCGTGCCCACAGCCACGAAGAGGCCAGCCGACCTG
CAGCCACTTCCACCCGGCTCTTCACTGACCCGCTGGCACTGCTGGGGCTGCCAGCAGAGGAACCAGAGCCTGCCTTCCCACCAGTGCTTG
AGCCTCGATGGTTTGCCCACTATGACGTGCAAAGCCTGCTCTTTGATTGGGCTCCGAGGTCTCAGGGGATGGGGAGCCACTCAGAGGCCA
GCTCTGGGACCCTGGCTTCAGCCGAGGACCAGGCTGCCAGCTCGGACCTGCTGCATGGGGCACCTGGCTTTGTGTGTGAGCTCGGGGGTG
AGGGTGAGCTAGGCCTGGGTGGACCAGCATCCCCACCTGTGCCCCCTGCACTGCCCAACGCGGCCGTGTCCATCCTGGAGGAGCCACAGA
ACCGAACCTCGGCCTACAGCCTGGAGCACGCAGACCTGGGTGCTGGCTACTACCGCAAATACTTCTATGGCAAAGAACATCAGAACTTCT
TCGGGATGGACGAGTCGCTGGGCCCGGTGGCAGTGAGCCTGCGGCGGGAGGAGAAGGAGGGCAGCGGAGGGGGCACCCTGCACAGCTACC
GCGTCATCGTGCGGACCACGCAGCTCCGGACACTCCGTGGCACCATCTCGGAGGACGCGCTGCCGCCGGGGCCCCCACGGGGTCTGTCCC
CAAGGAAACTTCTGGAGCACGTGGCGCCGCAGCTGAGCCCCAGCTGCCTGCGCCTGGGCTCAGCTTCACCCAAGGTACCACGGACGCTGC
TCACACTGGATGAGCAAGTGCTGAGCTTCCAACGCAAGGTGGGCATCCTGTACTGCCGGGCGGGCCAGGGCTCGGAGGAGGAGATGTACA
ACAACCAGGAGGCGGGACCGGCCTTCATGCAGTTTCTCACCTTGCTGGGCGATGTGGTGCGGCTCAAAGGCTTTGAGAGTTACCGGGCCC
AGCTAGACACCAAAAGCAAGGGGATCAGGCGAGTGAAGCCGAAGCGCACCACATCCTTCTTCAGCCGGCAGCTGTCCTTGGGCCAGGGGA
GCTACACCGTGGTGCAGCCCGGCGACAGCCTGGAGCAGGGCTGAGGACGCTGCACCCGGCAGGAGGAGGGCGACTGGGGGCCCTGGCCCG
GCACTGTCCTCCTGAGGGGCAGGCGCCGGCTGCAACAGTCTCATGGGTCACCACGTGGGGAGGGCTGCCTCAGCAGGTTTCTCAGACCAC
GGAGAAGTGACTTTTGGGCCCGGGGCCATGCCCGGGCTGTGCAAAGCTGGCCAGGGCCTCCTGTAGGGCTCCTCTGCAGCCTGCCCTCCC
TTCCCCCGGATGCTGGGCCCTGCTGCTCTCTCAGGACCATCCGATCAAGCTGCAGCTGCCACCCTCACCTAGAAACATGCCTTTGTGCCC
ACCTCAAGATGGGCAGTGTCCCTGTTCTGAAGTGCCCAGTGGCAGCTCCAGTGGTAGAGGACCAAGGATTGAGGTTTGGGACCTGAAGCT
CCAGTGTGTGCCTTTGGCCTCTTCCCTGGACTTGGGTGACCAGTCTCCGTCTTCCTCCTGCTAGTGCTCCACCCCCCGGACTTGGATGAC
CAGTTTCCCACCTTCCTCCTGCTGGTGCTCCATCCCCCAATACCAGGCTGGGCCACCACTCTGAGGAGGGTAGGAGGGGCCTCCCTGGAT
TGAACCGGGACAGAAACACGGTGAGGGCCCCCACCACACCTCCCTGGTTGAATCAGGAATGGAGGGAGCCAGGCAGGGCCCTACCTGGGG
TCCTGTGCCCCTCGTTCTGGTCTCCTTTGCAGGCACGAGATACCAGAAAGAGCATGCCTTTCTGATAGCCTTTGGTGATGTCACTGCTGG
GAGGTGGCTATCCTGTGGACCACCTGGCCTCCAGACCCACACTCACAGTCTGTGAAAAACTGAAAATCCCCTGGTGGGCACTCCCTGGAG
CCCAAGCAGCTCCCCTAGGGGACTGACCGGACCTGACCTCCCCTCCCTGTGTCTGGGTCTTCAGGTTTTAGTTTGGTCTTTGTTCATCTG
AGTTGTGCTGGGGCAACGCCAGGAAGTGCCCTGGGTACCTCTGCTGTGCGCTCCTTCCCAGGTGGCGCCATGGATTCCTCTGGGGGCTGG
CGCATGCCCAGGAAAGCCTGGGCCACACGGGACACTCTCTTCTTTATCGAGGACACTTGGAAAGGTGACTGATATGGGTGCTTGGCTTCT
CTGGTCCCAGCTTGCCCTCCGGGGAGCAGGGGCTCTGTCTTGTCCCAGATGAGCTGAGAGCCCCTGAGAGGAGGGCTTTCCCAGCCCTGG
GACCCTCCGAGGTGGGTGTGCGGGTCTCACAGGTGCTTCCTGGGACTTCCTGTGGCTGCACAGGGCTTGGCTTTGTCTTCGTTCCCGGTG
GAAAACCGTGGGAGAGGAAGCTTGGGCCTCTACTCCAAGTATCAGAGCCTGTTCACCCTCCTCCCTTTGGTAGCTTGTGAATGTGCCAGG
TGTTTCGAGGTAGGCTTGCCTTCTGGCAGCATGGACTTTGTTAAAATAATAGGCGGAAAGAAGAGGCCTGGGAAGGGCCCCCAGTCTTTT
GGAATGTCCTGGTCACAGGGTCATGTCAGCTGCCAGTTCTCGTCTCCCGTCCTGGAGTTGCTCGGTCTTGCGGAGCTGCCCGCCTGCCTG
TTCTGGCGGCTCCAGCGCAGGCTGTCCCTGCTGCTTTGATTCCAGGTGATTTTATTTTTTTTATTTTTTTATTTTTTTTGAGACGGAGTC
TTGCTCTGTTGCCCAGGCAGGAGTGCAGTGGCGCATCTCGGCTCACTGCAACCTCTGTCTCAAGCGATTCTCCTGCCTCAGCCTCCTGAG
TAGCTGGGATTACAGGTGCATGCCACCAGGCCCCGCTGATTTTTGTATTTTTAGTAGAGATAGGGTTTCACCATGTTGGTCAGGCTGGTC
GTGAACTCCTGACCTCATGATCTGCCCGCCTCAACCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCACCGCCCCCAGCTGATTCCAGGC
GAATTCTTCTCTGATGGGCGGGCGAGGGTGTGTTCGTGTGATGGGTTGGAGTGTGTGTGTCTGAGTACACAGATGATGTGTTTTCCCTTC
AGCTTCTTACGTTTTCTGAGCATCCATTGTGCCTTAACATTTTCTGCTTGTCCTTTGGGACAAAGCAGTATTTTACTCATTCTTTGAATG

>81933_81933_5_SIPA1-FRMD8_SIPA1_chr11_65412600_ENST00000394224_FRMD8_chr11_65178713_ENST00000317568_length(amino acids)=425AA_BP=387
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT
DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL
RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF

--------------------------------------------------------------
>81933_81933_6_SIPA1-FRMD8_SIPA1_chr11_65412600_ENST00000394227_FRMD8_chr11_65178713_ENST00000317568_length(transcript)=3537nt_BP=1253nt
CAGGGCAGGAACTGCTGCCACAACCTCAGGCTGGGCACCAAACACCCGTGCCCGCCAATGCGGCCCAGCCCCCGGAGAGTCAGGCCCACA
GAGCATGCCCATGTGGGCCGGCGGTGTGGGGAGCCCTCGGCGGGGCATGGCCCCTGCGTCCACAGATGACCTCTTTGCCCGCAAGCTGCG
CCAGCCAGCAAGGCCCCCGCTGACACCGCACACCTTCGAGCCGAGGCCAGTCCGGGGCCCACTCCTGCGCAGCGGCAGCGATGCAGGCGA
GGCCAGGCCCCCCACGCCAGCCAGCCCCCGTGCCCGTGCCCACAGCCACGAAGAGGCCAGCCGACCTGCAGCCACTTCCACCCGGCTCTT
CACTGACCCGCTGGCACTGCTGGGGCTGCCAGCAGAGGAACCAGAGCCTGCCTTCCCACCAGTGCTTGAGCCTCGATGGTTTGCCCACTA
TGACGTGCAAAGCCTGCTCTTTGATTGGGCTCCGAGGTCTCAGGGGATGGGGAGCCACTCAGAGGCCAGCTCTGGGACCCTGGCTTCAGC
CGAGGACCAGGCTGCCAGCTCGGACCTGCTGCATGGGGCACCTGGCTTTGTGTGTGAGCTCGGGGGTGAGGGTGAGCTAGGCCTGGGTGG
ACCAGCATCCCCACCTGTGCCCCCTGCACTGCCCAACGCGGCCGTGTCCATCCTGGAGGAGCCACAGAACCGAACCTCGGCCTACAGCCT
GGAGCACGCAGACCTGGGTGCTGGCTACTACCGCAAATACTTCTATGGCAAAGAACATCAGAACTTCTTCGGGATGGACGAGTCGCTGGG
CCCGGTGGCAGTGAGCCTGCGGCGGGAGGAGAAGGAGGGCAGCGGAGGGGGCACCCTGCACAGCTACCGCGTCATCGTGCGGACCACGCA
GCTCCGGACACTCCGTGGCACCATCTCGGAGGACGCGCTGCCGCCGGGGCCCCCACGGGGTCTGTCCCCAAGGAAACTTCTGGAGCACGT
GGCGCCGCAGCTGAGCCCCAGCTGCCTGCGCCTGGGCTCAGCTTCACCCAAGGTACCACGGACGCTGCTCACACTGGATGAGCAAGTGCT
GAGCTTCCAACGCAAGGTGGGCATCCTGTACTGCCGGGCGGGCCAGGGCTCGGAGGAGGAGATGTACAACAACCAGGAGGCGGGACCGGC
CTTCATGCAGTTTCTCACCTTGCTGGGCGATGTGGTGCGGCTCAAAGGCTTTGAGAGTTACCGGGCCCAGCTAGACACCAAAAGCAAGGG
GATCAGGCGAGTGAAGCCGAAGCGCACCACATCCTTCTTCAGCCGGCAGCTGTCCTTGGGCCAGGGGAGCTACACCGTGGTGCAGCCCGG
CGACAGCCTGGAGCAGGGCTGAGGACGCTGCACCCGGCAGGAGGAGGGCGACTGGGGGCCCTGGCCCGGCACTGTCCTCCTGAGGGGCAG
GCGCCGGCTGCAACAGTCTCATGGGTCACCACGTGGGGAGGGCTGCCTCAGCAGGTTTCTCAGACCACGGAGAAGTGACTTTTGGGCCCG
GGGCCATGCCCGGGCTGTGCAAAGCTGGCCAGGGCCTCCTGTAGGGCTCCTCTGCAGCCTGCCCTCCCTTCCCCCGGATGCTGGGCCCTG
CTGCTCTCTCAGGACCATCCGATCAAGCTGCAGCTGCCACCCTCACCTAGAAACATGCCTTTGTGCCCACCTCAAGATGGGCAGTGTCCC
TGTTCTGAAGTGCCCAGTGGCAGCTCCAGTGGTAGAGGACCAAGGATTGAGGTTTGGGACCTGAAGCTCCAGTGTGTGCCTTTGGCCTCT
TCCCTGGACTTGGGTGACCAGTCTCCGTCTTCCTCCTGCTAGTGCTCCACCCCCCGGACTTGGATGACCAGTTTCCCACCTTCCTCCTGC
TGGTGCTCCATCCCCCAATACCAGGCTGGGCCACCACTCTGAGGAGGGTAGGAGGGGCCTCCCTGGATTGAACCGGGACAGAAACACGGT
GAGGGCCCCCACCACACCTCCCTGGTTGAATCAGGAATGGAGGGAGCCAGGCAGGGCCCTACCTGGGGTCCTGTGCCCCTCGTTCTGGTC
TCCTTTGCAGGCACGAGATACCAGAAAGAGCATGCCTTTCTGATAGCCTTTGGTGATGTCACTGCTGGGAGGTGGCTATCCTGTGGACCA
CCTGGCCTCCAGACCCACACTCACAGTCTGTGAAAAACTGAAAATCCCCTGGTGGGCACTCCCTGGAGCCCAAGCAGCTCCCCTAGGGGA
CTGACCGGACCTGACCTCCCCTCCCTGTGTCTGGGTCTTCAGGTTTTAGTTTGGTCTTTGTTCATCTGAGTTGTGCTGGGGCAACGCCAG
GAAGTGCCCTGGGTACCTCTGCTGTGCGCTCCTTCCCAGGTGGCGCCATGGATTCCTCTGGGGGCTGGCGCATGCCCAGGAAAGCCTGGG
CCACACGGGACACTCTCTTCTTTATCGAGGACACTTGGAAAGGTGACTGATATGGGTGCTTGGCTTCTCTGGTCCCAGCTTGCCCTCCGG
GGAGCAGGGGCTCTGTCTTGTCCCAGATGAGCTGAGAGCCCCTGAGAGGAGGGCTTTCCCAGCCCTGGGACCCTCCGAGGTGGGTGTGCG
GGTCTCACAGGTGCTTCCTGGGACTTCCTGTGGCTGCACAGGGCTTGGCTTTGTCTTCGTTCCCGGTGGAAAACCGTGGGAGAGGAAGCT
TGGGCCTCTACTCCAAGTATCAGAGCCTGTTCACCCTCCTCCCTTTGGTAGCTTGTGAATGTGCCAGGTGTTTCGAGGTAGGCTTGCCTT
CTGGCAGCATGGACTTTGTTAAAATAATAGGCGGAAAGAAGAGGCCTGGGAAGGGCCCCCAGTCTTTTGGAATGTCCTGGTCACAGGGTC
ATGTCAGCTGCCAGTTCTCGTCTCCCGTCCTGGAGTTGCTCGGTCTTGCGGAGCTGCCCGCCTGCCTGTTCTGGCGGCTCCAGCGCAGGC
TGTCCCTGCTGCTTTGATTCCAGGTGATTTTATTTTTTTTATTTTTTTATTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCAGGA
GTGCAGTGGCGCATCTCGGCTCACTGCAACCTCTGTCTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCATG
CCACCAGGCCCCGCTGATTTTTGTATTTTTAGTAGAGATAGGGTTTCACCATGTTGGTCAGGCTGGTCGTGAACTCCTGACCTCATGATC
TGCCCGCCTCAACCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCACCGCCCCCAGCTGATTCCAGGCGAATTCTTCTCTGATGGGCGGG
CGAGGGTGTGTTCGTGTGATGGGTTGGAGTGTGTGTGTCTGAGTACACAGATGATGTGTTTTCCCTTCAGCTTCTTACGTTTTCTGAGCA
TCCATTGTGCCTTAACATTTTCTGCTTGTCCTTTGGGACAAAGCAGTATTTTACTCATTCTTTGAATGTTCTCATTCTTTTGTATCATGT

>81933_81933_6_SIPA1-FRMD8_SIPA1_chr11_65412600_ENST00000394227_FRMD8_chr11_65178713_ENST00000317568_length(amino acids)=425AA_BP=387
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT
DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL
RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF

--------------------------------------------------------------
>81933_81933_7_SIPA1-FRMD8_SIPA1_chr11_65412600_ENST00000527525_FRMD8_chr11_65178713_ENST00000317568_length(transcript)=3690nt_BP=1406nt
AGGTGCAGCCCTGCTTAGGGCCTGGAGATGGGCAGACCCAGGCTCACATCCTAGCTCTGACACGGAATTGCTTCAGGCAAGAGCATCTCC
TCTGGACCTCATCTGACCATCTGTCACATGGGGTTCAGACCTCCCTGTCTGCATCAGTGAGACCAGGGCAGGAACTGCTGCCACAACCTC
AGGCTGGGCACCAAACACCCGTGCCCGCCAATGCGGCCCAGCCCCCGGAGAGTCAGGCCCACAGAGCATGCCCATGTGGGCCGGCGGTGT
GGGGAGCCCTCGGCGGGGCATGGCCCCTGCGTCCACAGATGACCTCTTTGCCCGCAAGCTGCGCCAGCCAGCAAGGCCCCCGCTGACACC
GCACACCTTCGAGCCGAGGCCAGTCCGGGGCCCACTCCTGCGCAGCGGCAGCGATGCAGGCGAGGCCAGGCCCCCCACGCCAGCCAGCCC
CCGTGCCCGTGCCCACAGCCACGAAGAGGCCAGCCGACCTGCAGCCACTTCCACCCGGCTCTTCACTGACCCGCTGGCACTGCTGGGGCT
GCCAGCAGAGGAACCAGAGCCTGCCTTCCCACCAGTGCTTGAGCCTCGATGGTTTGCCCACTATGACGTGCAAAGCCTGCTCTTTGATTG
GGCTCCGAGGTCTCAGGGGATGGGGAGCCACTCAGAGGCCAGCTCTGGGACCCTGGCTTCAGCCGAGGACCAGGCTGCCAGCTCGGACCT
GCTGCATGGGGCACCTGGCTTTGTGTGTGAGCTCGGGGGTGAGGGTGAGCTAGGCCTGGGTGGACCAGCATCCCCACCTGTGCCCCCTGC
ACTGCCCAACGCGGCCGTGTCCATCCTGGAGGAGCCACAGAACCGAACCTCGGCCTACAGCCTGGAGCACGCAGACCTGGGTGCTGGCTA
CTACCGCAAATACTTCTATGGCAAAGAACATCAGAACTTCTTCGGGATGGACGAGTCGCTGGGCCCGGTGGCAGTGAGCCTGCGGCGGGA
GGAGAAGGAGGGCAGCGGAGGGGGCACCCTGCACAGCTACCGCGTCATCGTGCGGACCACGCAGCTCCGGACACTCCGTGGCACCATCTC
GGAGGACGCGCTGCCGCCGGGGCCCCCACGGGGTCTGTCCCCAAGGAAACTTCTGGAGCACGTGGCGCCGCAGCTGAGCCCCAGCTGCCT
GCGCCTGGGCTCAGCTTCACCCAAGGTACCACGGACGCTGCTCACACTGGATGAGCAAGTGCTGAGCTTCCAACGCAAGGTGGGCATCCT
GTACTGCCGGGCGGGCCAGGGCTCGGAGGAGGAGATGTACAACAACCAGGAGGCGGGACCGGCCTTCATGCAGTTTCTCACCTTGCTGGG
CGATGTGGTGCGGCTCAAAGGCTTTGAGAGTTACCGGGCCCAGCTAGACACCAAAAGCAAGGGGATCAGGCGAGTGAAGCCGAAGCGCAC
CACATCCTTCTTCAGCCGGCAGCTGTCCTTGGGCCAGGGGAGCTACACCGTGGTGCAGCCCGGCGACAGCCTGGAGCAGGGCTGAGGACG
CTGCACCCGGCAGGAGGAGGGCGACTGGGGGCCCTGGCCCGGCACTGTCCTCCTGAGGGGCAGGCGCCGGCTGCAACAGTCTCATGGGTC
ACCACGTGGGGAGGGCTGCCTCAGCAGGTTTCTCAGACCACGGAGAAGTGACTTTTGGGCCCGGGGCCATGCCCGGGCTGTGCAAAGCTG
GCCAGGGCCTCCTGTAGGGCTCCTCTGCAGCCTGCCCTCCCTTCCCCCGGATGCTGGGCCCTGCTGCTCTCTCAGGACCATCCGATCAAG
CTGCAGCTGCCACCCTCACCTAGAAACATGCCTTTGTGCCCACCTCAAGATGGGCAGTGTCCCTGTTCTGAAGTGCCCAGTGGCAGCTCC
AGTGGTAGAGGACCAAGGATTGAGGTTTGGGACCTGAAGCTCCAGTGTGTGCCTTTGGCCTCTTCCCTGGACTTGGGTGACCAGTCTCCG
TCTTCCTCCTGCTAGTGCTCCACCCCCCGGACTTGGATGACCAGTTTCCCACCTTCCTCCTGCTGGTGCTCCATCCCCCAATACCAGGCT
GGGCCACCACTCTGAGGAGGGTAGGAGGGGCCTCCCTGGATTGAACCGGGACAGAAACACGGTGAGGGCCCCCACCACACCTCCCTGGTT
GAATCAGGAATGGAGGGAGCCAGGCAGGGCCCTACCTGGGGTCCTGTGCCCCTCGTTCTGGTCTCCTTTGCAGGCACGAGATACCAGAAA
GAGCATGCCTTTCTGATAGCCTTTGGTGATGTCACTGCTGGGAGGTGGCTATCCTGTGGACCACCTGGCCTCCAGACCCACACTCACAGT
CTGTGAAAAACTGAAAATCCCCTGGTGGGCACTCCCTGGAGCCCAAGCAGCTCCCCTAGGGGACTGACCGGACCTGACCTCCCCTCCCTG
TGTCTGGGTCTTCAGGTTTTAGTTTGGTCTTTGTTCATCTGAGTTGTGCTGGGGCAACGCCAGGAAGTGCCCTGGGTACCTCTGCTGTGC
GCTCCTTCCCAGGTGGCGCCATGGATTCCTCTGGGGGCTGGCGCATGCCCAGGAAAGCCTGGGCCACACGGGACACTCTCTTCTTTATCG
AGGACACTTGGAAAGGTGACTGATATGGGTGCTTGGCTTCTCTGGTCCCAGCTTGCCCTCCGGGGAGCAGGGGCTCTGTCTTGTCCCAGA
TGAGCTGAGAGCCCCTGAGAGGAGGGCTTTCCCAGCCCTGGGACCCTCCGAGGTGGGTGTGCGGGTCTCACAGGTGCTTCCTGGGACTTC
CTGTGGCTGCACAGGGCTTGGCTTTGTCTTCGTTCCCGGTGGAAAACCGTGGGAGAGGAAGCTTGGGCCTCTACTCCAAGTATCAGAGCC
TGTTCACCCTCCTCCCTTTGGTAGCTTGTGAATGTGCCAGGTGTTTCGAGGTAGGCTTGCCTTCTGGCAGCATGGACTTTGTTAAAATAA
TAGGCGGAAAGAAGAGGCCTGGGAAGGGCCCCCAGTCTTTTGGAATGTCCTGGTCACAGGGTCATGTCAGCTGCCAGTTCTCGTCTCCCG
TCCTGGAGTTGCTCGGTCTTGCGGAGCTGCCCGCCTGCCTGTTCTGGCGGCTCCAGCGCAGGCTGTCCCTGCTGCTTTGATTCCAGGTGA
TTTTATTTTTTTTATTTTTTTATTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCAGGAGTGCAGTGGCGCATCTCGGCTCACTGC
AACCTCTGTCTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCATGCCACCAGGCCCCGCTGATTTTTGTATT
TTTAGTAGAGATAGGGTTTCACCATGTTGGTCAGGCTGGTCGTGAACTCCTGACCTCATGATCTGCCCGCCTCAACCTCCCAAAGTGCTG
GGATTATAGGCGTGAGCCACCGCCCCCAGCTGATTCCAGGCGAATTCTTCTCTGATGGGCGGGCGAGGGTGTGTTCGTGTGATGGGTTGG
AGTGTGTGTGTCTGAGTACACAGATGATGTGTTTTCCCTTCAGCTTCTTACGTTTTCTGAGCATCCATTGTGCCTTAACATTTTCTGCTT
GTCCTTTGGGACAAAGCAGTATTTTACTCATTCTTTGAATGTTCTCATTCTTTTGTATCATGTGACTTATTAAAATCAGTTTCTAACAAA

>81933_81933_7_SIPA1-FRMD8_SIPA1_chr11_65412600_ENST00000527525_FRMD8_chr11_65178713_ENST00000317568_length(amino acids)=425AA_BP=387
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT
DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL
RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF

--------------------------------------------------------------
>81933_81933_8_SIPA1-FRMD8_SIPA1_chr11_65412600_ENST00000534313_FRMD8_chr11_65178713_ENST00000317568_length(transcript)=3620nt_BP=1336nt
AGGCGGAGCCGGCGCCGGGAGCGGTAGCGGGAGAGCGGCAGCGGGACCCCAGCGCGGGCGGCGGCGGCTGGGCGGGAGCCCCAGAGGGCA
GGAACTGCTGCCACAACCTCAGGCTGGGCACCAAACACCCGTGCCCGCCAATGCGGCCCAGCCCCCGGAGAGTCAGGCCCACAGAGCATG
CCCATGTGGGCCGGCGGTGTGGGGAGCCCTCGGCGGGGCATGGCCCCTGCGTCCACAGATGACCTCTTTGCCCGCAAGCTGCGCCAGCCA
GCAAGGCCCCCGCTGACACCGCACACCTTCGAGCCGAGGCCAGTCCGGGGCCCACTCCTGCGCAGCGGCAGCGATGCAGGCGAGGCCAGG
CCCCCCACGCCAGCCAGCCCCCGTGCCCGTGCCCACAGCCACGAAGAGGCCAGCCGACCTGCAGCCACTTCCACCCGGCTCTTCACTGAC
CCGCTGGCACTGCTGGGGCTGCCAGCAGAGGAACCAGAGCCTGCCTTCCCACCAGTGCTTGAGCCTCGATGGTTTGCCCACTATGACGTG
CAAAGCCTGCTCTTTGATTGGGCTCCGAGGTCTCAGGGGATGGGGAGCCACTCAGAGGCCAGCTCTGGGACCCTGGCTTCAGCCGAGGAC
CAGGCTGCCAGCTCGGACCTGCTGCATGGGGCACCTGGCTTTGTGTGTGAGCTCGGGGGTGAGGGTGAGCTAGGCCTGGGTGGACCAGCA
TCCCCACCTGTGCCCCCTGCACTGCCCAACGCGGCCGTGTCCATCCTGGAGGAGCCACAGAACCGAACCTCGGCCTACAGCCTGGAGCAC
GCAGACCTGGGTGCTGGCTACTACCGCAAATACTTCTATGGCAAAGAACATCAGAACTTCTTCGGGATGGACGAGTCGCTGGGCCCGGTG
GCAGTGAGCCTGCGGCGGGAGGAGAAGGAGGGCAGCGGAGGGGGCACCCTGCACAGCTACCGCGTCATCGTGCGGACCACGCAGCTCCGG
ACACTCCGTGGCACCATCTCGGAGGACGCGCTGCCGCCGGGGCCCCCACGGGGTCTGTCCCCAAGGAAACTTCTGGAGCACGTGGCGCCG
CAGCTGAGCCCCAGCTGCCTGCGCCTGGGCTCAGCTTCACCCAAGGTACCACGGACGCTGCTCACACTGGATGAGCAAGTGCTGAGCTTC
CAACGCAAGGTGGGCATCCTGTACTGCCGGGCGGGCCAGGGCTCGGAGGAGGAGATGTACAACAACCAGGAGGCGGGACCGGCCTTCATG
CAGTTTCTCACCTTGCTGGGCGATGTGGTGCGGCTCAAAGGCTTTGAGAGTTACCGGGCCCAGCTAGACACCAAAAGCAAGGGGATCAGG
CGAGTGAAGCCGAAGCGCACCACATCCTTCTTCAGCCGGCAGCTGTCCTTGGGCCAGGGGAGCTACACCGTGGTGCAGCCCGGCGACAGC
CTGGAGCAGGGCTGAGGACGCTGCACCCGGCAGGAGGAGGGCGACTGGGGGCCCTGGCCCGGCACTGTCCTCCTGAGGGGCAGGCGCCGG
CTGCAACAGTCTCATGGGTCACCACGTGGGGAGGGCTGCCTCAGCAGGTTTCTCAGACCACGGAGAAGTGACTTTTGGGCCCGGGGCCAT
GCCCGGGCTGTGCAAAGCTGGCCAGGGCCTCCTGTAGGGCTCCTCTGCAGCCTGCCCTCCCTTCCCCCGGATGCTGGGCCCTGCTGCTCT
CTCAGGACCATCCGATCAAGCTGCAGCTGCCACCCTCACCTAGAAACATGCCTTTGTGCCCACCTCAAGATGGGCAGTGTCCCTGTTCTG
AAGTGCCCAGTGGCAGCTCCAGTGGTAGAGGACCAAGGATTGAGGTTTGGGACCTGAAGCTCCAGTGTGTGCCTTTGGCCTCTTCCCTGG
ACTTGGGTGACCAGTCTCCGTCTTCCTCCTGCTAGTGCTCCACCCCCCGGACTTGGATGACCAGTTTCCCACCTTCCTCCTGCTGGTGCT
CCATCCCCCAATACCAGGCTGGGCCACCACTCTGAGGAGGGTAGGAGGGGCCTCCCTGGATTGAACCGGGACAGAAACACGGTGAGGGCC
CCCACCACACCTCCCTGGTTGAATCAGGAATGGAGGGAGCCAGGCAGGGCCCTACCTGGGGTCCTGTGCCCCTCGTTCTGGTCTCCTTTG
CAGGCACGAGATACCAGAAAGAGCATGCCTTTCTGATAGCCTTTGGTGATGTCACTGCTGGGAGGTGGCTATCCTGTGGACCACCTGGCC
TCCAGACCCACACTCACAGTCTGTGAAAAACTGAAAATCCCCTGGTGGGCACTCCCTGGAGCCCAAGCAGCTCCCCTAGGGGACTGACCG
GACCTGACCTCCCCTCCCTGTGTCTGGGTCTTCAGGTTTTAGTTTGGTCTTTGTTCATCTGAGTTGTGCTGGGGCAACGCCAGGAAGTGC
CCTGGGTACCTCTGCTGTGCGCTCCTTCCCAGGTGGCGCCATGGATTCCTCTGGGGGCTGGCGCATGCCCAGGAAAGCCTGGGCCACACG
GGACACTCTCTTCTTTATCGAGGACACTTGGAAAGGTGACTGATATGGGTGCTTGGCTTCTCTGGTCCCAGCTTGCCCTCCGGGGAGCAG
GGGCTCTGTCTTGTCCCAGATGAGCTGAGAGCCCCTGAGAGGAGGGCTTTCCCAGCCCTGGGACCCTCCGAGGTGGGTGTGCGGGTCTCA
CAGGTGCTTCCTGGGACTTCCTGTGGCTGCACAGGGCTTGGCTTTGTCTTCGTTCCCGGTGGAAAACCGTGGGAGAGGAAGCTTGGGCCT
CTACTCCAAGTATCAGAGCCTGTTCACCCTCCTCCCTTTGGTAGCTTGTGAATGTGCCAGGTGTTTCGAGGTAGGCTTGCCTTCTGGCAG
CATGGACTTTGTTAAAATAATAGGCGGAAAGAAGAGGCCTGGGAAGGGCCCCCAGTCTTTTGGAATGTCCTGGTCACAGGGTCATGTCAG
CTGCCAGTTCTCGTCTCCCGTCCTGGAGTTGCTCGGTCTTGCGGAGCTGCCCGCCTGCCTGTTCTGGCGGCTCCAGCGCAGGCTGTCCCT
GCTGCTTTGATTCCAGGTGATTTTATTTTTTTTATTTTTTTATTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCAGGAGTGCAGT
GGCGCATCTCGGCTCACTGCAACCTCTGTCTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGATTACAGGTGCATGCCACCAG
GCCCCGCTGATTTTTGTATTTTTAGTAGAGATAGGGTTTCACCATGTTGGTCAGGCTGGTCGTGAACTCCTGACCTCATGATCTGCCCGC
CTCAACCTCCCAAAGTGCTGGGATTATAGGCGTGAGCCACCGCCCCCAGCTGATTCCAGGCGAATTCTTCTCTGATGGGCGGGCGAGGGT
GTGTTCGTGTGATGGGTTGGAGTGTGTGTGTCTGAGTACACAGATGATGTGTTTTCCCTTCAGCTTCTTACGTTTTCTGAGCATCCATTG
TGCCTTAACATTTTCTGCTTGTCCTTTGGGACAAAGCAGTATTTTACTCATTCTTTGAATGTTCTCATTCTTTTGTATCATGTGACTTAT

>81933_81933_8_SIPA1-FRMD8_SIPA1_chr11_65412600_ENST00000534313_FRMD8_chr11_65178713_ENST00000317568_length(amino acids)=425AA_BP=387
MPMWAGGVGSPRRGMAPASTDDLFARKLRQPARPPLTPHTFEPRPVRGPLLRSGSDAGEARPPTPASPRARAHSHEEASRPAATSTRLFT
DPLALLGLPAEEPEPAFPPVLEPRWFAHYDVQSLLFDWAPRSQGMGSHSEASSGTLASAEDQAASSDLLHGAPGFVCELGGEGELGLGGP
ASPPVPPALPNAAVSILEEPQNRTSAYSLEHADLGAGYYRKYFYGKEHQNFFGMDESLGPVAVSLRREEKEGSGGGTLHSYRVIVRTTQL
RTLRGTISEDALPPGPPRGLSPRKLLEHVAPQLSPSCLRLGSASPKVPRTLLTLDEQVLSFQRKVGILYCRAGQGSEEEMYNNQEAGPAF

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SIPA1-FRMD8


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SIPA1-FRMD8


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SIPA1-FRMD8


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource