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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SIPA1L1-MAX (FusionGDB2 ID:81936)

Fusion Gene Summary for SIPA1L1-MAX

check button Fusion gene summary
Fusion gene informationFusion gene name: SIPA1L1-MAX
Fusion gene ID: 81936
HgeneTgene
Gene symbol

SIPA1L1

MAX

Gene ID

26037

4149

Gene namesignal induced proliferation associated 1 like 1MYC associated factor X
SynonymsE6TP1|SPAR1bHLHd4
Cytomap

14q24.2

14q23.3

Type of geneprotein-codingprotein-coding
Descriptionsignal-induced proliferation-associated 1-like protein 1SIPA1-like protein 1high-risk human papilloma viruses E6 oncoproteins targeted protein 1spine-associated RapGAP 1protein maxclass D basic helix-loop-helix protein 4
Modification date2020031320200313
UniProtAcc.

P61244

Ensembl transtripts involved in fusion geneENST00000358550, ENST00000381232, 
ENST00000537413, ENST00000554874, 
ENST00000555818, 		ENST00000555667, 
ENST00000556443, ENST00000556979, 
ENST00000557277, ENST00000557746, 
ENST00000246163, ENST00000284165, 
ENST00000341653, ENST00000358402, 
ENST00000358664, ENST00000555419, 
ENST00000555932, 
Fusion gene scores* DoF score13 X 9 X 5=5857 X 5 X 3=105
# samples 147
** MAII scorelog2(14/585*10)=-2.0630097975258
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/105*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SIPA1L1 [Title/Abstract] AND MAX [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSIPA1L1(71787898)-MAX(65544754), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMAX

GO:0000122

negative regulation of transcription by RNA polymerase II

8521822


check buttonFusion gene breakpoints across SIPA1L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across MAX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-D7-6822-01ASIPA1L1chr14

71787898

+MAXchr14

65544754

-


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Fusion Gene ORF analysis for SIPA1L1-MAX

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-5UTRENST00000358550ENST00000555667SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000358550ENST00000556443SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000358550ENST00000556979SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000358550ENST00000557277SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000358550ENST00000557746SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000381232ENST00000555667SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000381232ENST00000556443SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000381232ENST00000556979SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000381232ENST00000557277SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000381232ENST00000557746SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000537413ENST00000555667SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000537413ENST00000556443SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000537413ENST00000556979SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000537413ENST00000557277SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000537413ENST00000557746SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000554874ENST00000555667SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000554874ENST00000556443SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000554874ENST00000556979SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000554874ENST00000557277SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000554874ENST00000557746SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000555818ENST00000555667SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000555818ENST00000556443SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000555818ENST00000556979SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000555818ENST00000557277SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-5UTRENST00000555818ENST00000557746SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000358550ENST00000246163SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000358550ENST00000284165SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000358550ENST00000341653SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000358550ENST00000358402SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000358550ENST00000358664SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000358550ENST00000555419SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000358550ENST00000555932SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000381232ENST00000246163SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000381232ENST00000284165SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000381232ENST00000341653SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000381232ENST00000358402SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000381232ENST00000358664SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000381232ENST00000555419SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000381232ENST00000555932SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000537413ENST00000246163SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000537413ENST00000284165SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000537413ENST00000341653SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000537413ENST00000358402SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000537413ENST00000358664SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000537413ENST00000555419SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000537413ENST00000555932SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000554874ENST00000246163SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000554874ENST00000284165SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000554874ENST00000341653SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000554874ENST00000358402SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000554874ENST00000358664SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000554874ENST00000555419SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000554874ENST00000555932SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000555818ENST00000246163SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000555818ENST00000284165SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000555818ENST00000341653SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000555818ENST00000358402SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000555818ENST00000358664SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000555818ENST00000555419SIPA1L1chr14

71787898

+MAXchr14

65544754

-
intron-intronENST00000555818ENST00000555932SIPA1L1chr14

71787898

+MAXchr14

65544754

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SIPA1L1-MAX


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SIPA1L1-MAX


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:71787898/:65544754)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.MAX

P61244

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC:MAX complex is a transcriptional activator, whereas the MAD:MAX complex is a repressor. May repress transcription via the recruitment of a chromatin remodeling complex containing H3 'Lys-9' histone methyltransferase activity. Represses MYC transcriptional activity from E-box elements. {ECO:0000269|PubMed:26070438}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SIPA1L1-MAX


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SIPA1L1-MAX


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SIPA1L1-MAX


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SIPA1L1-MAX


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource