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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SIPA1L2-NTPCR (FusionGDB2 ID:81948)

Fusion Gene Summary for SIPA1L2-NTPCR

Fusion gene summary

Fusion gene information	Fusion gene name: SIPA1L2-NTPCR
	Fusion gene ID: 81948
		Hgene	Tgene
	Gene symbol	SIPA1L2	NTPCR
	Gene ID	57568	84284
	Gene name	signal induced proliferation associated 1 like 2	nucleoside-triphosphatase, cancer-related
	Synonyms	SPAL2\|SPAR2	C1orf57\|HCR-NTPase\|THEP1
	Cytomap	1q42.2	1q42.2
	Type of gene	protein-coding	protein-coding
	Description	signal-induced proliferation-associated 1-like protein 2SIPA1-like protein 2SPA-1-like 2spine-associated RapGAP 2	cancer-related nucleoside-triphosphatasehuman cancer-related NTPasenucleoside triphosphate phosphohydrolasenucleoside-triphosphatase C1orf57
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000262861, ENST00000366630, ENST00000486472, ENST00000308942,	ENST00000490098, ENST00000366627, ENST00000366628,
Fusion gene scores	* DoF score	5 X 5 X 5=125	5 X 5 X 4=100
	# samples	5	6
	** MAII score	log2(5/125*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/100*10)=-0.736965594166206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SIPA1L2 [Title/Abstract] AND NTPCR [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SIPA1L2(232629273)-NTPCR(233113909), # samples:3
Anticipated loss of major functional domain due to fusion event.	SIPA1L2-NTPCR seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across SIPA1L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NTPCR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	MESO	TCGA-SH-A9CU-01A	SIPA1L2	chr1	232629273	-	NTPCR	chr1	233113909	+
ChimerDB4	MESO	TCGA-SH-A9CU	SIPA1L2	chr1	232629273	-	NTPCR	chr1	233113909	+

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Fusion Gene ORF analysis for SIPA1L2-NTPCR

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-3UTR	ENST00000262861	ENST00000490098	SIPA1L2	chr1	232629273	-	NTPCR	chr1	233113909	+
5CDS-3UTR	ENST00000366630	ENST00000490098	SIPA1L2	chr1	232629273	-	NTPCR	chr1	233113909	+
5CDS-intron	ENST00000262861	ENST00000366627	SIPA1L2	chr1	232629273	-	NTPCR	chr1	233113909	+
5CDS-intron	ENST00000366630	ENST00000366627	SIPA1L2	chr1	232629273	-	NTPCR	chr1	233113909	+
5UTR-3CDS	ENST00000486472	ENST00000366628	SIPA1L2	chr1	232629273	-	NTPCR	chr1	233113909	+
5UTR-3UTR	ENST00000486472	ENST00000490098	SIPA1L2	chr1	232629273	-	NTPCR	chr1	233113909	+
5UTR-intron	ENST00000486472	ENST00000366627	SIPA1L2	chr1	232629273	-	NTPCR	chr1	233113909	+
Frame-shift	ENST00000262861	ENST00000366628	SIPA1L2	chr1	232629273	-	NTPCR	chr1	233113909	+
In-frame	ENST00000366630	ENST00000366628	SIPA1L2	chr1	232629273	-	NTPCR	chr1	233113909	+
intron-3CDS	ENST00000308942	ENST00000366628	SIPA1L2	chr1	232629273	-	NTPCR	chr1	233113909	+
intron-3UTR	ENST00000308942	ENST00000490098	SIPA1L2	chr1	232629273	-	NTPCR	chr1	233113909	+
intron-intron	ENST00000308942	ENST00000366627	SIPA1L2	chr1	232629273	-	NTPCR	chr1	233113909	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000366630

SIPA1L2

chr1

232629273

ENST00000366628

NTPCR

chr1

233113909

7696

1976

326

2044

572

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000366630	ENST00000366628	SIPA1L2	chr1	232629273	-	NTPCR	chr1	233113909	+	0.000382351	0.9996176

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Fusion Genomic Features for SIPA1L2-NTPCR

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SIPA1L2	chr1	232629272	-	NTPCR	chr1	233113908	+	0.000245748	0.99975425
SIPA1L2	chr1	232629272	-	NTPCR	chr1	233113908	+	0.000245748	0.99975425
SIPA1L2	chr1	232629272	-	NTPCR	chr1	233113908	+	0.000245748	0.99975425
SIPA1L2	chr1	232629272	-	NTPCR	chr1	233113908	+	0.000245748	0.99975425

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SIPA1L2-NTPCR

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:232629273/chr1:233113909)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000262861

60_63

539

1723.0

Compositional bias

Note=Poly-Gly

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000366630

60_63

539

1723.0

Compositional bias

Note=Poly-Gly

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000262861

1654_1712

539

1723.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000308942

1654_1712

779.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000366630

1654_1712

539

1723.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000262861

1125_1128

539

1723.0

Compositional bias

Note=Poly-Ser

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000262861

1321_1384

539

1723.0

Compositional bias

Note=Ser-rich

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000308942

1125_1128

779.0

Compositional bias

Note=Poly-Ser

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000308942

1321_1384

779.0

Compositional bias

Note=Ser-rich

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000308942

60_63

779.0

Compositional bias

Note=Poly-Gly

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000366630

1125_1128

539

1723.0

Compositional bias

Note=Poly-Ser

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000366630

1321_1384

539

1723.0

Compositional bias

Note=Ser-rich

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000262861

595_812

539

1723.0

Domain

Rap-GAP

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000262861

950_1026

539

1723.0

Domain

PDZ

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000308942

595_812

779.0

Domain

Rap-GAP

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000308942

950_1026

779.0

Domain

PDZ

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000366630

595_812

539

1723.0

Domain

Rap-GAP

Hgene

SIPA1L2

chr1:232629273

chr1:233113909

ENST00000366630

950_1026

539

1723.0

Domain

PDZ

Tgene

NTPCR

chr1:232629273

chr1:233113909

ENST00000366628

109_116

168

191.0

Nucleotide binding

ATP

Tgene

NTPCR

chr1:232629273

chr1:233113909

ENST00000366628

9_16

168

191.0

Nucleotide binding

ATP

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Fusion Gene Sequence for SIPA1L2-NTPCR

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>81948_81948_1_SIPA1L2-NTPCR_SIPA1L2_chr1_232629273_ENST00000366630_NTPCR_chr1_233113909_ENST00000366628_length(transcript)=7696nt_BP=1976nt
ACTAGGGGTGGGCATTGTGTGTGGCTCCCCTGTGGTAGAGAAGGACATCGGATGAACATGTGATCTGTGTATCCAGCTCCAACCCAAAAG
GTGAAGGAAATACTCATGACCAGCCAGATGTCTTAAGGAATGCTTTTGAAAAGAACAGAGGCGTACAACATTATTACGACAACAGAGAAG
CAAGTTGGCTTTGAAGAAACTGTATTCTGAGGATGTTGTTTGCTTTGGGCTAAGAAAAGAAAAAATACAACTACAGACAAAGCCTTTATA
TCTGCAAGTATTATGGCGTGGTCGGTAGCAATGTAATTAGATTTACATCAGTCTTCCTGGTGAGACTTGGAGGCTCTTCCTCGGTAGACA
TGAGTGACCCAAGGCAGTCACAAGAAGAGAAGCACAAGCTAGGCAGAGCCTCTTCAAAGTTCAAGGATCCCCCTAGAATCATGCAGTCAG
ATGATTATTTTGCTCGGAAATTTAAAGCCATTAATGGCAACATGGGACCCACTACTTCTTTAAATGCCTCGAATTCCAATGAGACTGGCG
GTGGTGGTCCGGCTAATGGTACCCCAGCTGTGCCCAAGATGGGTGTGAGAGCAAGGGTGTCTGAATGGCCTCCTAAAAAGGACTGTTCCA
AGGAGCTAACATGCAAGGCACTGTGGGAAAGCCGGTCTCAGACCAGTTATGAAAGCATCACTTCTGTCCTGCAGAATGGGCAGAGTGACC
AGAGTGAAGGTCAGCAAGATGAACAGCTCGATCTGGACTTCGTGGAGGCCAAGTACACAATCGGAGACATCTTTGTCCATTCCCCCCAAA
GAGGACTTCACCCCATAAGACAGAGGAGCAATAGTGATGTCACTATCAGTGACATTGATGCCGAAGATGTCTTAGACCAAAATGCAGTCA
ACCCCAACACCGGGGCTGCCCTGCACAGGGAGTATGGAAGTACTTCATCCATCGACAGGCAAGGCTTATCTGGTGAAAACTTTTTTGCTA
TGCTCAGAGGGTACCGAGTAGAAAATTATGACCACAAAGCAATGGTCCCTTTTGGGTTCCCTGAATTTTTCCGCTGTGACCCTGCAATCT
CTCCGAGCCTTCATGCAGCAGCACAGATTTCTAGGGGAGAATTTGTCCGCATCTCAGGATTAGATTATGTGGACAGTGCCCTCCTGATGG
GGAGAGACAGGGACAAGCCTTTCAAACGGAGGTTGAAATCAGAGTCGGTGGAAACATCTCTCTTCCGAAAGCTTCGAACTGTTAAAAGTG
AGCACGAAACTTTCAAGTTCACGTCTGAGCTGGAGGAGAGCCGACTGGAGAGGGGCATTCGCCCTTGGAATTGTCAGCGATGTTTTGCAC
ATTATGATGTCCAGAGCATTTTGTTTAATATCAACGAAGCCATGGCTACGAGGGCTAATGTGGGGAAAAGGAAAAACATAACCACTGGGG
CATCTGCAGCATCCCAGACTCAGATGCCTACGGGCCAGACAGGCAACTGTGAGTCCCCTTTAGGGAGCAAGGAGGACCTCAACTCCAAAG
AGAACCTGGATGCCGATGAGGGTGATGGGAAAAGTAACGACCTCGTCCTTAGTTGTCCTTACTTTAGAAATGAGACTGGAGGGGAAGGCG
ACAGGCGGATTGCGCTCTCTCGAGCCAACTCATCCTCTTTCAGTTCTGGGGAAAGCTGCTCTTTCGAATCGTCACTCAGCTCTCACTGCA
CAAATGCAGGTGTCTCCGTCTTGGAAGTGCCCAGAGAAAACCAGCCTATTCACAGGGAGAAAGTGAAGCGCTACATCATAGAACACATTG
ACCTTGGGGCCTATTATTACCGCAAATTCTTCTATGGGAAAGAGCACCAAAACTACTTTGGAATAGATGAAAACCTTGGTCCAGTAGCAG
TCAGCATCCGGAGAGAGAAGGTGGAAGATGCCAAGGAGAAAGAAGGATCCCAGTTCAACTACAGGGTGGCTTTCAGGACAAGTGAGGTCA
CCAAGGAAAACAGAAACCACCTTCTGCCAGATATCGTGACGTGCGTGCAGAGCAGCAGGAAGTGAAGACACGTGCATTCCTGCCTTCCGT
GAAGGAGTGCCCAGTTCAAGAGGAGCCTGATGGAGCCCTGCCTGTCGAGGCTGTATGCCTATGGGGTTATGGAACCTTGTGGGCTTTTCT
AGAGAAAACTCAACAGCTGTTTCCCATAAAATGTTTAAAAGATCAAATTAGCCTTAATGCTGGATTGTCTGTACAAGATTAACTATCCAT
TGTGGCTTATCTATGCTTAAAGATTTCTTGTTTATTTCCTCTTGCAGTCATGCACATGATTTGGGTAAACTGTGAGATGAGAAATGGTTT
TCAGAGTATTAGATGGAATTCACCCCCGTTGAAGTTTATAAATGTGTTCAGGGGAAGCGGGAGGAAAGAGTTCACTGCCTAATCAGTTTT
GCATGTCATGAAAATTAAATTCCTCTCCAGGTGCAGCTTCAGCCTCATGCAACTTAAAGTGATAACAGTTATTTGATTTTTTAAAAAATA
TTATTCCAAAAGAAAACCATTTTAGGTCATCTCCCCCAACTCTGTTTGCTTACTGCTTAATAAATATAAAAATAAATCTGATGGTTACAG
ACAGGAGGCATTGTGTGGGAGGAATACACAACCTTTGGAAGTGTTGATAGCATCTGATATTCAGCCGACCAGATGACAAGAGCTCAGGCC
CACGGGTTTGCATAAGAGCACTGCTTTGCCTTAGTTTACTCGGGAGCAATTTTGAATCTTTCTATGCCTAGTTTCCCTTCCAGAAAAGCA
GGAAGTGGCTGTCATCTCAGGAGTGATGTCACACCACAGAAGGAAACTGTCAACCACTCCACACAACTGTGGAGAGTGCCCAGTGCCAGG
GGCTGGGCTTATCAGGAATAATGGTGTAGCAATGCGGAGTTCAGCCCATAACAGGGGTACTATAAAAATGAAGTAGGAAAGTAGAAGAGA
CCCCTGAAACCCCAGAACTGATAGAGGATAAAAACTTCCCTCCAAGTGGTAGATGGTACTGGAGTGATAAACAGTTCAGTGTTTTTAGGT
CATTTTTGGTGAAGATCTATGAATTTCCAGGATTTTTTTTTAACAAATTAGCATTGGCTACAAACCCACTGGTATAAGCAGCAGTGTGCC
TTCTCTCTAACTGTGGACAAGTCGGGCATGTGGCGGGTGAGGAGCCCTGGGCTGGGCACTGGGGCACAGTGAATGGGGCGGGAGGGGCTC
ACATCAAAACCAAAATGGCACGCAGCCCAGGTCTGGTTCCTCCATCAGTGTCTCTTTCCTCAGCGCTTTTCTTCCGAGGTAACTTTGTGA
AGCTTGACTTGGACTTGCCTAGCCTTGGAGGGACCACAACAGGGAGGCCTAATAGATTATGAACTAAGCCCTCAAAAGGGCTACCTGCCC
AGGAGGAGGAAGTGGGCATCTCCTTCCACAGTCCCTGCCTGGCGGGGCTGTTCAGGGAGACTGAGTTCCGAGCTCAGGATGTCTGGCAGG
CTGGCTGTGACTTCCAGCCACCATCACCAGGACACCGGTGTGGGCTGCATGCCTCAGTGGGCCAGGAGAGGCACGGCCTCTGAGTTGGGT
AGAGGCTTCCCACAAAGGCCTGGGAACCTGATCCTGGCCGTAAATCTGAAAGTACCACAGCCCTCAGGAGAACCAAGAGATAGGGAGGCA
GGCTGGGGAAATGTCATCAATGTGCACCCAGGCGTGGTGGAGCTGGTCAGCCCCAGCTGGAGTGGGACCCCATCAAGATGGAGCCTTTCC
TGGCACCTCCGGGAGGCCGTTTTGCGTTTCCGCCCTTCATGCATCTGAAACACCAAGGGCCATGTTCCTTCTGGTGCTTGTCCTTTTGAG
CTTGGTGTTTCAGCCGTGTCTGTTTTGTAGACTTTGATTTTGTCTTAAATGAGAAAGAAAGCTGGTGAAGGTTATTTCAAAGTTAAATAG
CTAGTCTGAGGGGCTTATCACTGAAGCCAGTTGTGCTTATGTGGGGTGGGAGTGTCACTGCCTACTTGAAAGTATGCACTTGTGTGGAAC
AGATTCAGGGTGGCCCCTAGCACTTGGGGCTGCGGGAGCTTCTGCACACTTTCCCTTTAACGGTAAAGAGACAAGCTTGGAGTGTTTAAG
TGGTTCGTTCAGGAGCACAGTGATAGCGGTGACAAAGGAGATTTGAACCCACGTCTGCGTGGCTCCAAAGTTCACTCTTTCATCACTCCC
TGCTGCGTCCTTCTTGAGGCTTTAGCATTTTTAGTGTGTTTTGTGCCCCCAGACCTCAGAGTTGACATTTAGCAGTGATAAACTGCTGTA
AATCCAAAGAACGTTTAGTGTCTCTTGTGGTGAGGTCCTGAAATGATTGTTGTATTAGTCAAACAGAATGATCATGGAGCATGTATGGAG
ATGTCAGATGCAATCCCTGTATTGTAAGGCAATGACATTTAATGAAGGATAAGATGAATTCACAGATAACTAGAACTCAGGGCCAAACGC
ACACAGCCTGTAGCAACAGTGTCATGCTGAGATTTAAAGGAAGAAGAGGTGCCGTGGCAGAACTCCACGTGACCGTCCCCTCCCTGCACG
CAGCCAGGATGAGAGGAGCAGAGCTGAGCGCCACCTCCCTGTCGGTGCCACGGCTGAGGTGAGGAGCTCTTGCCGGATGGTGGGGTGGGG
GCAGCAGGGCAGATTGAAGTCAGGGATTCTCTTATACCTGAGTTTGGAATGCCTCCTATTCAAACAAAGCAAAATATCTAACAGATGGTT
GGATATGAGTCTCAGGGAGGAATTCAATTTGAAAAGCACAGAATTAACATGTATTGCTTATATGAAGAATCTCAGCTAGAATAACAAGGT
CGGATGGGAGGAATCAGGACTGATTTGAAGCACGATTTACTAAATCATTCTTTCCTTTTCCTCCTTAGCAGATCATACCGCCAGCTGCTT
AACACGTAATAGTTTAATAAATTGTTTCTTCTTACCTCTCAGTGAGGGTAAGCACATGCAGGGAGATGGGTGAGTCTTTTAAATGGATAG
TGTCATCTCTGATGATCAGCCTTGACAGGGAGAGATCCTAGTAAAGCTGCAAATTCAGGCACTCAGTTCCCAGCCCTCCAGTTATCAAGG
GGGTGGGAACGCTGGTGGGCTGGAAAATGTGGAACAGACCTGCTCCTCTTCTTTTCCTGCCAATTACCGTATTCATAGAAGGTTGTGTCT
GTGGATCACACCTGTGTGTGTGCTGATGGCGGATGCTTGTGTAGCATAGTGACTTGGGACAAAACAGCATGGTAGATGAGGCTGGAGACG
GGTGGGCTAAGTAAACAGGCATTGCATTGCACATTTTGTGGGCAAAGAAGTTGAAGCATCGCATGATTTTAACAAATTACTTGCCAGATG
ATTTCAACACACTGCAAAATTTAGAATCAATAATGCCAAATTGGCCACATGATTTATATAAAACCAAGTGCTATGGTTTTAATATTATCT
TTAGAGGAGAAACCATTTTGATCTGTGTCCAAATAACTCTTTTTTTTTTTTTTTTTTTTGAGACAGAGTCTCACTCTGTCGCTTGAGCTG
GAGTGCAGTGGTGCTATCTCGGCTCACTGTAACCTCCGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAACCTCCTGAGTAGCTGGGATT
ACAGGCACCCGCCACCACGCCCAGCTAATTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAAGCTGGTCTCGAACTCCT
GACCTCATGATTTGCCTGCCTCAGCCTACAAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCCAGCCCCCAAATAACTCTTGAACTG
GAAAATAACTCTTTAGCTATATACTGGCAGAATATTTGAACAACTCTAGCAAGAAATGTCAGTTTAGGGATGCCTCCTCTAAATGGGGGC
TTAGAATATAACATTTTGCAGGAAGTCCTTTCTGATACATAGCTGACTAGATGAAGGACCAGATTAACAAGTTCATGAGTTGTAAATATA
AAAGTTGTGTACCACGATAAAAAAGAAAAAGAAGTATGGCTGCACTGTTGATGGCTGGTCAAACAGCCCCCAAGAATCCTGGGGTGACTC
CAATACTGCCACCTTTTCTCTGTGGGTGCAGTTGCCTGCGGATGTGTGTGCACATCTGTGCCTCGGTATGCACACTCGAGATGCCCGCTC
TCATAGACGGTGCAGAGCGTCACTGCATTCCTATCTGATTAATGTGACCTTAGTGTTGTAGATACACTGTGTCACTTTCATCCTCCCTCC
TCCCCACAAAAGATGCCACGAGAACTCGTGAACTGTGATAAGCAATGAACAGAATAACTGTTGAAGAAGCACCTCATGAACCTCCCCAGA
GAAACGGGATGGAGGAGCACCCAGGGTGCTCTTGCTCTCTTGCCTGCGCTGCCATTTCCTTCCAGCCTGGGTTTCTAGCTCTTTGGGGAG
ATTCCCCGTTTTGTGGAATGCTTTCTGTGTTTCCTACTTCTGGATGCCTAAGGAGTGGCCAGTCATACTCCTGGCTGACCACTGCCAGGC
ACCGTGGTTTTCCTCACTGAACTCAAGGAGTCACCCTCCGTGGGGAGGCCACACTCACAGCTCCAGGCCTGCCATTTAGCCCTTGGGGCT
TGGCTGTAAAGTTGCCCAAGAGGATTACAGGAGCTGCCAGCCAAGTTTAATTTGGCCACCTTAGAGAACTGCAGCAAGGCCCTATCAGCT
TCCCATTAGACAAACAACTGCATTTAAATTAAATAAAGTTTGCACCTCTAGGGAGTGCTGACCTGAAAATAAGAACCTTCTGTCTGTGAT
TATAGAGTACACTTGCTTTTATTAATTGCTGATTCTTAGTTTACAAAAAAAAAAATTAGAAAAGCATTACCATTTACTTTCCAAGGGGCA
AGAGATTCTCTACAATACCCTTCCCCCAACCCTCTCCTCAAATTTCCAAATCCTAAATACTTTGAAGAAATTTGTGTGACTGTTTAAAAT
TGAGTATTTCCTTCTAACTATTGTCTTTTGAAAAGGGATGGTTCACCAGGCCAGTGATACTCTATGGACTGCATTTTGGGACCTCTACCC
CAGCAAGGATACAGGTTCCTGGGGTCTTGAAGATGGGAAAAGTTGTCTCAGAATTTACCCAAATGTCGTTCTCACCATAAAAGATATACT
TGTAGAAATGAGAAGCTTCAGTATAACTCAAAACACTGGACGCAGCAATAACTATAAACATTTTAATTTCAAAAACAAAGGTGTGTGCGA
TGTTGTGTGCACAGTAAGGGTTGCGGGGCTTGGAGAACAAGCACGCGTCCCTGTGAAGCCCGCAGGGTGCTGGCGGCCCACCAATCGCCT
GGACTACAGTGAGGAGCATTGTGTGACTCCGCGGTGGATTTCCATGCACCGAATGGACTCAGTTTCTAAACTCACATCCTAACGTATCCT
GGCTTTTCACAGAATACTGGAGACATGACTGCATGCATGATCACGGTTCTTGTTGTGAAGCTGCCACCATGTTACGCTTAACAGCTGCAT
AAATATTATAAAGAAATAGGGTTTTCTTGACACTTAGATTTAACCTTAATGCATCTGCCCAGCTGATGGTATCAGACGTGCTGCTGTTCA

>81948_81948_1_SIPA1L2-NTPCR_SIPA1L2_chr1_232629273_ENST00000366630_NTPCR_chr1_233113909_ENST00000366628_length(amino acids)=572AA_BP=550
MVRLGGSSSVDMSDPRQSQEEKHKLGRASSKFKDPPRIMQSDDYFARKFKAINGNMGPTTSLNASNSNETGGGGPANGTPAVPKMGVRAR
VSEWPPKKDCSKELTCKALWESRSQTSYESITSVLQNGQSDQSEGQQDEQLDLDFVEAKYTIGDIFVHSPQRGLHPIRQRSNSDVTISDI
DAEDVLDQNAVNPNTGAALHREYGSTSSIDRQGLSGENFFAMLRGYRVENYDHKAMVPFGFPEFFRCDPAISPSLHAAAQISRGEFVRIS
GLDYVDSALLMGRDRDKPFKRRLKSESVETSLFRKLRTVKSEHETFKFTSELEESRLERGIRPWNCQRCFAHYDVQSILFNINEAMATRA
NVGKRKNITTGASAASQTQMPTGQTGNCESPLGSKEDLNSKENLDADEGDGKSNDLVLSCPYFRNETGGEGDRRIALSRANSSSFSSGES
CSFESSLSSHCTNAGVSVLEVPRENQPIHREKVKRYIIEHIDLGAYYYRKFFYGKEHQNYFGIDENLGPVAVSIRREKVEDAKEKEGSQF

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Fusion Gene PPI Analysis for SIPA1L2-NTPCR

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SIPA1L2-NTPCR

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SIPA1L2-NTPCR

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source