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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SIRPB2-HSPA1A (FusionGDB2 ID:81988)

Fusion Gene Summary for SIRPB2-HSPA1A

check button Fusion gene summary
Fusion gene informationFusion gene name: SIRPB2-HSPA1A
Fusion gene ID: 81988
HgeneTgene
Gene symbol

SIRPB2

HSPA1A

Gene ID

284759

3303

Gene namesignal regulatory protein beta 2heat shock protein family A (Hsp70) member 1A
SynonymsPTPN1L|PTPNS1L3|dJ776F14.2HEL-S-103|HSP70-1|HSP70-1A|HSP70-2|HSP70.1|HSP70.2|HSP70I|HSP72|HSPA1
Cytomap

20p13

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionsignal-regulatory protein beta-2SIRP-beta-2protein tyrosine phosphatase non-receptor type substrate proteinprotein tyrosine phosphatase, non-receptor type substrate 1-like 3heat shock 70 kDa protein 1AHSP70-1/HSP70-2HSP70.1/HSP70.2Heat shock 70 kDa protein 1BHeat shock 70 kDa protein 2dnaK-type molecular chaperone HSP70-1epididymis secretory protein Li 103epididymis secretory sperm binding proteinheat shock 70 kDa pr
Modification date2020031320200327
UniProtAcc.

P0DMV8

Ensembl transtripts involved in fusion geneENST00000359801, ENST00000444444, 
ENST00000537284, ENST00000608747, 
ENST00000375651, ENST00000458062, 
ENST00000608703, ENST00000383389, 
ENST00000400040, ENST00000422919, 
ENST00000430065, ENST00000433487, 
ENST00000441618, ENST00000449876, 
ENST00000452298, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 15 X 4=360
# samples 111
** MAII scorelog2(1/1*10)=3.32192809488736log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SIRPB2 [Title/Abstract] AND HSPA1A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSIRPB2(1470878)-HSPA1A(31784817), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneHSPA1A

GO:0006402

mRNA catabolic process

10205060

TgeneHSPA1A

GO:0006986

response to unfolded protein

10859165

TgeneHSPA1A

GO:0031396

regulation of protein ubiquitination

16809764

TgeneHSPA1A

GO:0031397

negative regulation of protein ubiquitination

12150907

TgeneHSPA1A

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

24613385

TgeneHSPA1A

GO:0033120

positive regulation of RNA splicing

20625543

TgeneHSPA1A

GO:0034605

cellular response to heat

24061851

TgeneHSPA1A

GO:0042026

protein refolding

15603737|21231916

TgeneHSPA1A

GO:0046034

ATP metabolic process

23921388

TgeneHSPA1A

GO:0050821

protein stabilization

21909508

TgeneHSPA1A

GO:0051131

chaperone-mediated protein complex assembly

10811660

TgeneHSPA1A

GO:0090084

negative regulation of inclusion body assembly

15603737|21231916

TgeneHSPA1A

GO:0097201

negative regulation of transcription from RNA polymerase II promoter in response to stress

9499401

TgeneHSPA1A

GO:1901029

negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

20625543

TgeneHSPA1A

GO:1902236

negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway

12150907|20625543

TgeneHSPA1A

GO:1902380

positive regulation of endoribonuclease activity

20625543


check buttonFusion gene breakpoints across SIRPB2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across HSPA1A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAK097113SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+


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Fusion Gene ORF analysis for SIRPB2-HSPA1A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000359801ENST00000375651SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-3CDSENST00000359801ENST00000458062SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-3CDSENST00000359801ENST00000608703SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-3CDSENST00000444444ENST00000375651SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-3CDSENST00000444444ENST00000458062SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-3CDSENST00000444444ENST00000608703SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-3CDSENST00000537284ENST00000375651SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-3CDSENST00000537284ENST00000458062SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-3CDSENST00000537284ENST00000608703SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-3CDSENST00000608747ENST00000375651SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-3CDSENST00000608747ENST00000458062SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-3CDSENST00000608747ENST00000608703SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000359801ENST00000383389SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000359801ENST00000400040SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000359801ENST00000422919SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000359801ENST00000430065SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000359801ENST00000433487SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000359801ENST00000441618SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000359801ENST00000449876SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000359801ENST00000452298SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000444444ENST00000383389SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000444444ENST00000400040SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000444444ENST00000422919SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000444444ENST00000430065SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000444444ENST00000433487SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000444444ENST00000441618SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000444444ENST00000449876SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000444444ENST00000452298SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000537284ENST00000383389SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000537284ENST00000400040SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000537284ENST00000422919SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000537284ENST00000430065SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000537284ENST00000433487SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000537284ENST00000441618SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000537284ENST00000449876SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000537284ENST00000452298SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000608747ENST00000383389SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000608747ENST00000400040SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000608747ENST00000422919SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000608747ENST00000430065SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000608747ENST00000433487SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000608747ENST00000441618SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000608747ENST00000449876SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+
intron-intronENST00000608747ENST00000452298SIRPB2chr20

1470878

-HSPA1Achr6

31784817

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SIRPB2-HSPA1A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SIRPB2-HSPA1A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:1470878/:31784817)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HSPA1A

P0DMV8

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:26865365, PubMed:24318877). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223). Negatively regulates heat shock-induced HSF1 transcriptional activity during the attenuation and recovery phase period of the heat shock response (PubMed:9499401). Involved in the clearance of misfolded PRDM1/Blimp-1 proteins. Sequesters them in the cytoplasm and promotes their association with SYNV1/HRD1, leading to proteasomal degradation (PubMed:28842558). {ECO:0000269|PubMed:22528486, ECO:0000269|PubMed:23973223, ECO:0000269|PubMed:24318877, ECO:0000269|PubMed:24613385, ECO:0000269|PubMed:27137183, ECO:0000269|PubMed:27708256, ECO:0000269|PubMed:28842558, ECO:0000269|PubMed:9499401, ECO:0000303|PubMed:24012426, ECO:0000303|PubMed:26865365}.; FUNCTION: (Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell. {ECO:0000269|PubMed:16537599}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SIRPB2-HSPA1A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SIRPB2-HSPA1A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SIRPB2-HSPA1A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SIRPB2-HSPA1A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource