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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SKA1-NBAS (FusionGDB2 ID:82024)

Fusion Gene Summary for SKA1-NBAS

check button Fusion gene summary
Fusion gene informationFusion gene name: SKA1-NBAS
Fusion gene ID: 82024
HgeneTgene
Gene symbol

SKA1

NBAS

Gene ID

220134

51594

Gene namespindle and kinetochore associated complex subunit 1NBAS subunit of NRZ tethering complex
SynonymsC18orf24ILFS2|NAG|SOPH
Cytomap

18q21.1

2p24.3

Type of geneprotein-codingprotein-coding
Descriptionspindle and kinetochore-associated protein 1spindle and KT (kinetochore) associated 1neuroblastoma-amplified sequenceNAG/BC035112 fusionNAG/FAM49A fusionneuroblastoma amplified sequenceneuroblastoma-amplified gene protein
Modification date2020031320200313
UniProtAcc.

A2RRP1

Ensembl transtripts involved in fusion geneENST00000488454, ENST00000285116, 
ENST00000398452, ENST00000417656, 
ENST00000281513, ENST00000441750, 
Fusion gene scores* DoF score2 X 2 X 1=415 X 15 X 6=1350
# samples 215
** MAII scorelog2(2/4*10)=2.32192809488736log2(15/1350*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SKA1 [Title/Abstract] AND NBAS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSKA1(47902288)-NBAS(15449372), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSKA1

GO:0031110

regulation of microtubule polymerization or depolymerization

19289083


check buttonFusion gene breakpoints across SKA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NBAS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABE618276SKA1chr18

47902288

+NBASchr2

15449372

-


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Fusion Gene ORF analysis for SKA1-NBAS

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000488454ENST00000281513SKA1chr18

47902288

+NBASchr2

15449372

-
5UTR-3CDSENST00000488454ENST00000441750SKA1chr18

47902288

+NBASchr2

15449372

-
In-frameENST00000285116ENST00000281513SKA1chr18

47902288

+NBASchr2

15449372

-
In-frameENST00000285116ENST00000441750SKA1chr18

47902288

+NBASchr2

15449372

-
In-frameENST00000398452ENST00000281513SKA1chr18

47902288

+NBASchr2

15449372

-
In-frameENST00000398452ENST00000441750SKA1chr18

47902288

+NBASchr2

15449372

-
In-frameENST00000417656ENST00000281513SKA1chr18

47902288

+NBASchr2

15449372

-
In-frameENST00000417656ENST00000441750SKA1chr18

47902288

+NBASchr2

15449372

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000285116SKA1chr1847902288+ENST00000441750NBASchr215449372-29732992112832873
ENST00000285116SKA1chr1847902288+ENST00000281513NBASchr215449372-29722992112832873
ENST00000398452SKA1chr1847902288+ENST00000441750NBASchr215449372-29732992112832873
ENST00000398452SKA1chr1847902288+ENST00000281513NBASchr215449372-29722992112832873
ENST00000417656SKA1chr1847902288+ENST00000441750NBASchr215449372-29252511632784873
ENST00000417656SKA1chr1847902288+ENST00000281513NBASchr215449372-29242511632784873

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000285116ENST00000441750SKA1chr1847902288+NBASchr215449372-0.0044904330.9955096
ENST00000285116ENST00000281513SKA1chr1847902288+NBASchr215449372-0.0044544910.9955455
ENST00000398452ENST00000441750SKA1chr1847902288+NBASchr215449372-0.0037774350.9962225
ENST00000398452ENST00000281513SKA1chr1847902288+NBASchr215449372-0.0037468030.99625313
ENST00000417656ENST00000441750SKA1chr1847902288+NBASchr215449372-0.0042195250.99578047
ENST00000417656ENST00000281513SKA1chr1847902288+NBASchr215449372-0.0041777430.9958223

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Fusion Genomic Features for SKA1-NBAS


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SKA1-NBAS


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:47902288/chr2:15449372)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NBAS

A2RRP1

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport; the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER (PubMed:19369418). {ECO:0000269|PubMed:19369418, ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNBASchr18:47902288chr2:15449372ENST0000028151337522242_224715272372.0Compositional biasNote=Poly-Leu
TgeneNBASchr18:47902288chr2:15449372ENST0000044175035501421_142514072252.0Compositional biasNote=Poly-Thr
TgeneNBASchr18:47902288chr2:15449372ENST0000044175035502242_224714072252.0Compositional biasNote=Poly-Leu

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSKA1chr18:47902288chr2:15449372ENST00000285116+2749_9129256.0Coiled coilOntology_term=ECO:0000255
HgeneSKA1chr18:47902288chr2:15449372ENST00000398452+2749_9129256.0Coiled coilOntology_term=ECO:0000255
HgeneSKA1chr18:47902288chr2:15449372ENST00000417656+2649_9129210.0Coiled coilOntology_term=ECO:0000255
HgeneSKA1chr18:47902288chr2:15449372ENST00000285116+27132_25529256.0RegionMicrotubule binding
HgeneSKA1chr18:47902288chr2:15449372ENST00000398452+27132_25529256.0RegionMicrotubule binding
HgeneSKA1chr18:47902288chr2:15449372ENST00000417656+26132_25529210.0RegionMicrotubule binding
TgeneNBASchr18:47902288chr2:15449372ENST0000028151337521421_142515272372.0Compositional biasNote=Poly-Thr
TgeneNBASchr18:47902288chr2:15449372ENST000002815133752130_16915272372.0RepeatNote=WD 1
TgeneNBASchr18:47902288chr2:15449372ENST000002815133752316_35515272372.0RepeatNote=WD 2
TgeneNBASchr18:47902288chr2:15449372ENST000004417503550130_16914072252.0RepeatNote=WD 1
TgeneNBASchr18:47902288chr2:15449372ENST000004417503550316_35514072252.0RepeatNote=WD 2


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Fusion Gene Sequence for SKA1-NBAS


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>82024_82024_1_SKA1-NBAS_SKA1_chr18_47902288_ENST00000285116_NBAS_chr2_15449372_ENST00000281513_length(transcript)=2972nt_BP=299nt
GATGACGCAAACCGGGAACAGCGGCTGAGCCTGCGCTTCGGAAGCATGGATGTGCGCCTGCGCTGCGCTAGGGCGCGGCGGGCGGTTTGA
ATTTTGCTTACAGAGTCCCGTCTCACCATCCTGGGCTTCCAACGGAGACTGCGGTATCCGCAGCTGGAGACCCAGCGGCGAGTAGCCTTT
TGCTCCCGGACGGACTTGAGAGGCTTAAAGGATGGCCTCGTCAGATCTGGAACAATTATGCTCTCATGTTAATGAAAAGATTGGCAATAT
TAAGAAAACCTTATCATTAAGAAACTGTGTTCTCTTGCAACTAGCAAGTGAAGCCTTGCCAAATGACATGACCTTGGCTCTTGCTTACCT
TCTTGCCTTACCACAAGTGTTAGATGCTAACCGGTGCTTTGAAAAGCAGTCCCCCTCTGCATTATCTCTCCAGCTGGCAGCGTATTACTA
TAGCCTCCAGATCTATGCCCGATTGGCCCCATGTTTCAGGGACAAGTGCCATCCTCTTTACAGGGCTGATCCCAAAGAACTAATCAAGAT
GGTCACCAGGCATGTGACTCGACATGAGCACGAAGCCTGGCCTGAAGACCTTATTTCACTGACCAAGCAGTTACACTGCTACAATGAACG
TCTCCTGGATTTCACTCAGGCGCAGATCCTTCAGGGCCTTCGGAAGGGTGTGGACGTGCAGCGGTTTACTGCAGATGACCAGTATAAAAG
GGAAACTATCCTTGGTCTGGCAGAAACTCTAGAGGAAAGCGTCTACAGCATTGCTATTTCTCTGGCACAACGTTACAGTGTCTCCCGCTG
GGAAGTTTTTATGACCCATTTGGAGTTCCTCTTCACGGACAGTGGTTTGTCCACACTAGAAATTGAAAATAGAGCCCAAGACCTTCATCT
CTTTGAGACTTTGAAGACTGATCCAGAAGCCTTTCACCAGCACATGGTCAAGTATATTTACCCTACTATTGGTGGCTTTGATCACGAAAG
GCTGCAGTATTATTTCACTCTTCTGGAAAACTGTGGCTGTGCAGATTTGGGGAACTGTGCCATTAAACCAGAAACCCACATTCGACTGCT
GAAGAAGTTTAAGGTTGTTGCATCAGGTCTTAATTACAAAAAGCTGACAGATGAAAACATGAGTCCTCTTGAAGCATTGGAGCCAGTTCT
TTCAAGTCAAAATATCTTGTCTATTTCCAAACTTGTTCCCAAAATCCCTGAAAAGGATGGACAGATGCTTTCCCCAAGCTCTCTGTACAC
CATCTGGTTACAGAAGTTGTTCTGGACTGGAGACCCTCATCTCATTAAACAAGTCCCAGGCTCTTCACCGGAGTGGCTTCATGCCTATGA
TGTCTGCATGAAGTACTTTGATCGTCTCCACCCAGGTGACCTCATCACTGTGGTAGATGCAGTTACATTTTCTCCAAAAGCTGTGACCAA
GCTGTCTGTGGAAGCCCGTAAAGAGATGACTAGAAAGGCTATTAAGACAGTCAAACATTTTATTGAGAAGCCAAGGAAAAGAAACTCAGA
AGACGAAGCTCAAGAAGCTAAGGATTCTAAAGTTACCTATGCAGATACTTTGAATCATCTGGAGAAATCACTTGCCCACCTGGAAACCCT
GAGCCACAGCTTCATCCTTTCTCTGAAGAATAGTGAGCAGGAAACACTGCAAAAATACAGTCACCTCTATGATCTGTCCCGATCAGAAAA
AGAGAAACTTCATGATGAAGCTGTGGCTATTTGTTTAGATGGTCAGCCTCTAGCAATGATTCAGCAGCTGCTAGAGGTGGCAGTTGGCCC
TCTTGACATCTCACCCAAGGATATAGTGCAGAGTGCAATCATGAAAATAATTTCTGCATTGAGTGGTGGCAGTGCTGACCTTGGTGGGCC
AAGGGACCCACTGAAGGTCCTGGAAGGTGTTGTTGCAGCAGTCCACGCCAGTGTGGACAAGGGTGAGGAGCTGGTTTCACCTGAGGACCT
GCTGGAGTGGCTGCGGCCTTTCTGTGCTGATGACGCCTGGCCGGTGCGGCCCCGCATTCACGTGCTGCAGATTTTGGGGCAATCATTTCA
CCTGACTGAGGAGGACAGCAAGCTCCTCGTGTTCTTTAGAACTGAAGCCATTCTCAAAGCCTCCTGGCCCCAGAGACAGGTAGACATAGC
TGACATTGAGAATGAAGAGAACCGCTACTGTCTATTCATGGAACTCCTGGAATCTAGTCACCACGAGGCTGAATTTCAGCACTTGGTTTT
ACTTTTGCAAGCTTGGCCACCTATGAAAAGTGAATATGTCATAACCAATAATCCATGGGTGAGACTAGCTACAGTGATGCTAACCAGATG
TACGATGGAGAACAAGGAAGGATTGGGGAATGAAGTTTTGAAAATGTGTCGCTCTTTGTATAACACCAAGCAGATGCTGCCTGCAGAGGG
TGTGAAGGAGCTGTGTCTGCTGCTGCTTAACCAGTCCCTCCTGCTTCCATCTCTGAAACTTCTCCTCGAGAGCCGAGATGAGCATCTGCA
CGAGATGGCACTGGAGCAAATCACGGCAGTCACTACGGTGAATGATTCCAATTGTGACCAAGAACTTCTTTCCCTGCTCCTGGATGCCAA
GCTGCTGGTGAAGTGTGTCTCCACTCCCTTCTATCCACGTATTGTTGACCACCTCTTGGCTAGCCTCCAGCAAGGGCGCTGGGATGCAGA
GGAGCTGGGCAGACACCTGCGGGAGGCCGGCCATGAAGCCGAAGCCGGGTCTCTCCTTCTGGCCGTGAGGGGGACTCACCAGGCCTTCAG
AACCTTCAGTACAGCCCTCCGCGCAGCACAGCACTGGGTGTGAGGGCCACCTGTGGCCCTGCTCCTTAGCAGAAAAAGCATCTGGAGTTG
AATGCTGTTCCCAGAAGCAACATGTGTATCTGCCGATTGTTCTCCATGGTTCCAACAAATTGCAAATAAAACTGTATGGAAACGATGAGC

>82024_82024_1_SKA1-NBAS_SKA1_chr18_47902288_ENST00000285116_NBAS_chr2_15449372_ENST00000281513_length(amino acids)=873AA_BP=19
MASSDLEQLCSHVNEKIGNIKKTLSLRNCVLLQLASEALPNDMTLALAYLLALPQVLDANRCFEKQSPSALSLQLAAYYYSLQIYARLAP
CFRDKCHPLYRADPKELIKMVTRHVTRHEHEAWPEDLISLTKQLHCYNERLLDFTQAQILQGLRKGVDVQRFTADDQYKRETILGLAETL
EESVYSIAISLAQRYSVSRWEVFMTHLEFLFTDSGLSTLEIENRAQDLHLFETLKTDPEAFHQHMVKYIYPTIGGFDHERLQYYFTLLEN
CGCADLGNCAIKPETHIRLLKKFKVVASGLNYKKLTDENMSPLEALEPVLSSQNILSISKLVPKIPEKDGQMLSPSSLYTIWLQKLFWTG
DPHLIKQVPGSSPEWLHAYDVCMKYFDRLHPGDLITVVDAVTFSPKAVTKLSVEARKEMTRKAIKTVKHFIEKPRKRNSEDEAQEAKDSK
VTYADTLNHLEKSLAHLETLSHSFILSLKNSEQETLQKYSHLYDLSRSEKEKLHDEAVAICLDGQPLAMIQQLLEVAVGPLDISPKDIVQ
SAIMKIISALSGGSADLGGPRDPLKVLEGVVAAVHASVDKGEELVSPEDLLEWLRPFCADDAWPVRPRIHVLQILGQSFHLTEEDSKLLV
FFRTEAILKASWPQRQVDIADIENEENRYCLFMELLESSHHEAEFQHLVLLLQAWPPMKSEYVITNNPWVRLATVMLTRCTMENKEGLGN
EVLKMCRSLYNTKQMLPAEGVKELCLLLLNQSLLLPSLKLLLESRDEHLHEMALEQITAVTTVNDSNCDQELLSLLLDAKLLVKCVSTPF

--------------------------------------------------------------
>82024_82024_2_SKA1-NBAS_SKA1_chr18_47902288_ENST00000285116_NBAS_chr2_15449372_ENST00000441750_length(transcript)=2973nt_BP=299nt
GATGACGCAAACCGGGAACAGCGGCTGAGCCTGCGCTTCGGAAGCATGGATGTGCGCCTGCGCTGCGCTAGGGCGCGGCGGGCGGTTTGA
ATTTTGCTTACAGAGTCCCGTCTCACCATCCTGGGCTTCCAACGGAGACTGCGGTATCCGCAGCTGGAGACCCAGCGGCGAGTAGCCTTT
TGCTCCCGGACGGACTTGAGAGGCTTAAAGGATGGCCTCGTCAGATCTGGAACAATTATGCTCTCATGTTAATGAAAAGATTGGCAATAT
TAAGAAAACCTTATCATTAAGAAACTGTGTTCTCTTGCAACTAGCAAGTGAAGCCTTGCCAAATGACATGACCTTGGCTCTTGCTTACCT
TCTTGCCTTACCACAAGTGTTAGATGCTAACCGGTGCTTTGAAAAGCAGTCCCCCTCTGCATTATCTCTCCAGCTGGCAGCGTATTACTA
TAGCCTCCAGATCTATGCCCGATTGGCCCCATGTTTCAGGGACAAGTGCCATCCTCTTTACAGGGCTGATCCCAAAGAACTAATCAAGAT
GGTCACCAGGCATGTGACTCGACATGAGCACGAAGCCTGGCCTGAAGACCTTATTTCACTGACCAAGCAGTTACACTGCTACAATGAACG
TCTCCTGGATTTCACTCAGGCGCAGATCCTTCAGGGCCTTCGGAAGGGTGTGGACGTGCAGCGGTTTACTGCAGATGACCAGTATAAAAG
GGAAACTATCCTTGGTCTGGCAGAAACTCTAGAGGAAAGCGTCTACAGCATTGCTATTTCTCTGGCACAACGTTACAGTGTCTCCCGCTG
GGAAGTTTTTATGACCCATTTGGAGTTCCTCTTCACGGACAGTGGTTTGTCCACACTAGAAATTGAAAATAGAGCCCAAGACCTTCATCT
CTTTGAGACTTTGAAGACTGATCCAGAAGCCTTTCACCAGCACATGGTCAAGTATATTTACCCTACTATTGGTGGCTTTGATCACGAAAG
GCTGCAGTATTATTTCACTCTTCTGGAAAACTGTGGCTGTGCAGATTTGGGGAACTGTGCCATTAAACCAGAAACCCACATTCGACTGCT
GAAGAAGTTTAAGGTTGTTGCATCAGGTCTTAATTACAAAAAGCTGACAGATGAAAACATGAGTCCTCTTGAAGCATTGGAGCCAGTTCT
TTCAAGTCAAAATATCTTGTCTATTTCCAAACTTGTTCCCAAAATCCCTGAAAAGGATGGACAGATGCTTTCCCCAAGCTCTCTGTACAC
CATCTGGTTACAGAAGTTGTTCTGGACTGGAGACCCTCATCTCATTAAACAAGTCCCAGGCTCTTCACCGGAGTGGCTTCATGCCTATGA
TGTCTGCATGAAGTACTTTGATCGTCTCCACCCAGGTGACCTCATCACTGTGGTAGATGCAGTTACATTTTCTCCAAAAGCTGTGACCAA
GCTGTCTGTGGAAGCCCGTAAAGAGATGACTAGAAAGGCTATTAAGACAGTCAAACATTTTATTGAGAAGCCAAGGAAAAGAAACTCAGA
AGACGAAGCTCAAGAAGCTAAGGATTCTAAAGTTACCTATGCAGATACTTTGAATCATCTGGAGAAATCACTTGCCCACCTGGAAACCCT
GAGCCACAGCTTCATCCTTTCTCTGAAGAATAGTGAGCAGGAAACACTGCAAAAATACAGTCACCTCTATGATCTGTCCCGATCAGAAAA
AGAGAAACTTCATGATGAAGCTGTGGCTATTTGTTTAGATGGTCAGCCTCTAGCAATGATTCAGCAGCTGCTAGAGGTGGCAGTTGGCCC
TCTTGACATCTCACCCAAGGATATAGTGCAGAGTGCAATCATGAAAATAATTTCTGCATTGAGTGGTGGCAGTGCTGACCTTGGTGGGCC
AAGGGACCCACTGAAGGTCCTGGAAGGTGTTGTTGCAGCAGTCCACGCCAGTGTGGACAAGGGTGAGGAGCTGGTTTCACCTGAGGACCT
GCTGGAGTGGCTGCGGCCTTTCTGTGCTGATGACGCCTGGCCGGTGCGGCCCCGCATTCACGTGCTGCAGATTTTGGGGCAATCATTTCA
CCTGACTGAGGAGGACAGCAAGCTCCTCGTGTTCTTTAGAACTGAAGCCATTCTCAAAGCCTCCTGGCCCCAGAGACAGGTAGACATAGC
TGACATTGAGAATGAAGAGAACCGCTACTGTCTATTCATGGAACTCCTGGAATCTAGTCACCACGAGGCTGAATTTCAGCACTTGGTTTT
ACTTTTGCAAGCTTGGCCACCTATGAAAAGTGAATATGTCATAACCAATAATCCATGGGTGAGACTAGCTACAGTGATGCTAACCAGATG
TACGATGGAGAACAAGGAAGGATTGGGGAATGAAGTTTTGAAAATGTGTCGCTCTTTGTATAACACCAAGCAGATGCTGCCTGCAGAGGG
TGTGAAGGAGCTGTGTCTGCTGCTGCTTAACCAGTCCCTCCTGCTTCCATCTCTGAAACTTCTCCTCGAGAGCCGAGATGAGCATCTGCA
CGAGATGGCACTGGAGCAAATCACGGCAGTCACTACGGTGAATGATTCCAATTGTGACCAAGAACTTCTTTCCCTGCTCCTGGATGCCAA
GCTGCTGGTGAAGTGTGTCTCCACTCCCTTCTATCCACGTATTGTTGACCACCTCTTGGCTAGCCTCCAGCAAGGGCGCTGGGATGCAGA
GGAGCTGGGCAGACACCTGCGGGAGGCCGGCCATGAAGCCGAAGCCGGGTCTCTCCTTCTGGCCGTGAGGGGGACTCACCAGGCCTTCAG
AACCTTCAGTACAGCCCTCCGCGCAGCACAGCACTGGGTGTGAGGGCCACCTGTGGCCCTGCTCCTTAGCAGAAAAAGCATCTGGAGTTG
AATGCTGTTCCCAGAAGCAACATGTGTATCTGCCGATTGTTCTCCATGGTTCCAACAAATTGCAAATAAAACTGTATGGAAACGATGAGC

>82024_82024_2_SKA1-NBAS_SKA1_chr18_47902288_ENST00000285116_NBAS_chr2_15449372_ENST00000441750_length(amino acids)=873AA_BP=19
MASSDLEQLCSHVNEKIGNIKKTLSLRNCVLLQLASEALPNDMTLALAYLLALPQVLDANRCFEKQSPSALSLQLAAYYYSLQIYARLAP
CFRDKCHPLYRADPKELIKMVTRHVTRHEHEAWPEDLISLTKQLHCYNERLLDFTQAQILQGLRKGVDVQRFTADDQYKRETILGLAETL
EESVYSIAISLAQRYSVSRWEVFMTHLEFLFTDSGLSTLEIENRAQDLHLFETLKTDPEAFHQHMVKYIYPTIGGFDHERLQYYFTLLEN
CGCADLGNCAIKPETHIRLLKKFKVVASGLNYKKLTDENMSPLEALEPVLSSQNILSISKLVPKIPEKDGQMLSPSSLYTIWLQKLFWTG
DPHLIKQVPGSSPEWLHAYDVCMKYFDRLHPGDLITVVDAVTFSPKAVTKLSVEARKEMTRKAIKTVKHFIEKPRKRNSEDEAQEAKDSK
VTYADTLNHLEKSLAHLETLSHSFILSLKNSEQETLQKYSHLYDLSRSEKEKLHDEAVAICLDGQPLAMIQQLLEVAVGPLDISPKDIVQ
SAIMKIISALSGGSADLGGPRDPLKVLEGVVAAVHASVDKGEELVSPEDLLEWLRPFCADDAWPVRPRIHVLQILGQSFHLTEEDSKLLV
FFRTEAILKASWPQRQVDIADIENEENRYCLFMELLESSHHEAEFQHLVLLLQAWPPMKSEYVITNNPWVRLATVMLTRCTMENKEGLGN
EVLKMCRSLYNTKQMLPAEGVKELCLLLLNQSLLLPSLKLLLESRDEHLHEMALEQITAVTTVNDSNCDQELLSLLLDAKLLVKCVSTPF

--------------------------------------------------------------
>82024_82024_3_SKA1-NBAS_SKA1_chr18_47902288_ENST00000398452_NBAS_chr2_15449372_ENST00000281513_length(transcript)=2972nt_BP=299nt
ATGGATGTGCGCCTGCGCTGCGCTAGGGCGCGGCGGGCGGTTTGAATTTTGCTTACAGAGTCCCGTCTCACCATCCTGGGCTTCCAACGG
AGACTGCGGTATCCGCAGCTGGAGACCCAGCGGCGAGTAGCCTTTTGCTCCCGGACGGACTTGAGGTTGGAGTCTGTGTGTTGGGGACCC
TGCCTTTGGAAGCGCCCGAGAGGCTTAAAGGATGGCCTCGTCAGATCTGGAACAATTATGCTCTCATGTTAATGAAAAGATTGGCAATAT
TAAGAAAACCTTATCATTAAGAAACTGTGTTCTCTTGCAACTAGCAAGTGAAGCCTTGCCAAATGACATGACCTTGGCTCTTGCTTACCT
TCTTGCCTTACCACAAGTGTTAGATGCTAACCGGTGCTTTGAAAAGCAGTCCCCCTCTGCATTATCTCTCCAGCTGGCAGCGTATTACTA
TAGCCTCCAGATCTATGCCCGATTGGCCCCATGTTTCAGGGACAAGTGCCATCCTCTTTACAGGGCTGATCCCAAAGAACTAATCAAGAT
GGTCACCAGGCATGTGACTCGACATGAGCACGAAGCCTGGCCTGAAGACCTTATTTCACTGACCAAGCAGTTACACTGCTACAATGAACG
TCTCCTGGATTTCACTCAGGCGCAGATCCTTCAGGGCCTTCGGAAGGGTGTGGACGTGCAGCGGTTTACTGCAGATGACCAGTATAAAAG
GGAAACTATCCTTGGTCTGGCAGAAACTCTAGAGGAAAGCGTCTACAGCATTGCTATTTCTCTGGCACAACGTTACAGTGTCTCCCGCTG
GGAAGTTTTTATGACCCATTTGGAGTTCCTCTTCACGGACAGTGGTTTGTCCACACTAGAAATTGAAAATAGAGCCCAAGACCTTCATCT
CTTTGAGACTTTGAAGACTGATCCAGAAGCCTTTCACCAGCACATGGTCAAGTATATTTACCCTACTATTGGTGGCTTTGATCACGAAAG
GCTGCAGTATTATTTCACTCTTCTGGAAAACTGTGGCTGTGCAGATTTGGGGAACTGTGCCATTAAACCAGAAACCCACATTCGACTGCT
GAAGAAGTTTAAGGTTGTTGCATCAGGTCTTAATTACAAAAAGCTGACAGATGAAAACATGAGTCCTCTTGAAGCATTGGAGCCAGTTCT
TTCAAGTCAAAATATCTTGTCTATTTCCAAACTTGTTCCCAAAATCCCTGAAAAGGATGGACAGATGCTTTCCCCAAGCTCTCTGTACAC
CATCTGGTTACAGAAGTTGTTCTGGACTGGAGACCCTCATCTCATTAAACAAGTCCCAGGCTCTTCACCGGAGTGGCTTCATGCCTATGA
TGTCTGCATGAAGTACTTTGATCGTCTCCACCCAGGTGACCTCATCACTGTGGTAGATGCAGTTACATTTTCTCCAAAAGCTGTGACCAA
GCTGTCTGTGGAAGCCCGTAAAGAGATGACTAGAAAGGCTATTAAGACAGTCAAACATTTTATTGAGAAGCCAAGGAAAAGAAACTCAGA
AGACGAAGCTCAAGAAGCTAAGGATTCTAAAGTTACCTATGCAGATACTTTGAATCATCTGGAGAAATCACTTGCCCACCTGGAAACCCT
GAGCCACAGCTTCATCCTTTCTCTGAAGAATAGTGAGCAGGAAACACTGCAAAAATACAGTCACCTCTATGATCTGTCCCGATCAGAAAA
AGAGAAACTTCATGATGAAGCTGTGGCTATTTGTTTAGATGGTCAGCCTCTAGCAATGATTCAGCAGCTGCTAGAGGTGGCAGTTGGCCC
TCTTGACATCTCACCCAAGGATATAGTGCAGAGTGCAATCATGAAAATAATTTCTGCATTGAGTGGTGGCAGTGCTGACCTTGGTGGGCC
AAGGGACCCACTGAAGGTCCTGGAAGGTGTTGTTGCAGCAGTCCACGCCAGTGTGGACAAGGGTGAGGAGCTGGTTTCACCTGAGGACCT
GCTGGAGTGGCTGCGGCCTTTCTGTGCTGATGACGCCTGGCCGGTGCGGCCCCGCATTCACGTGCTGCAGATTTTGGGGCAATCATTTCA
CCTGACTGAGGAGGACAGCAAGCTCCTCGTGTTCTTTAGAACTGAAGCCATTCTCAAAGCCTCCTGGCCCCAGAGACAGGTAGACATAGC
TGACATTGAGAATGAAGAGAACCGCTACTGTCTATTCATGGAACTCCTGGAATCTAGTCACCACGAGGCTGAATTTCAGCACTTGGTTTT
ACTTTTGCAAGCTTGGCCACCTATGAAAAGTGAATATGTCATAACCAATAATCCATGGGTGAGACTAGCTACAGTGATGCTAACCAGATG
TACGATGGAGAACAAGGAAGGATTGGGGAATGAAGTTTTGAAAATGTGTCGCTCTTTGTATAACACCAAGCAGATGCTGCCTGCAGAGGG
TGTGAAGGAGCTGTGTCTGCTGCTGCTTAACCAGTCCCTCCTGCTTCCATCTCTGAAACTTCTCCTCGAGAGCCGAGATGAGCATCTGCA
CGAGATGGCACTGGAGCAAATCACGGCAGTCACTACGGTGAATGATTCCAATTGTGACCAAGAACTTCTTTCCCTGCTCCTGGATGCCAA
GCTGCTGGTGAAGTGTGTCTCCACTCCCTTCTATCCACGTATTGTTGACCACCTCTTGGCTAGCCTCCAGCAAGGGCGCTGGGATGCAGA
GGAGCTGGGCAGACACCTGCGGGAGGCCGGCCATGAAGCCGAAGCCGGGTCTCTCCTTCTGGCCGTGAGGGGGACTCACCAGGCCTTCAG
AACCTTCAGTACAGCCCTCCGCGCAGCACAGCACTGGGTGTGAGGGCCACCTGTGGCCCTGCTCCTTAGCAGAAAAAGCATCTGGAGTTG
AATGCTGTTCCCAGAAGCAACATGTGTATCTGCCGATTGTTCTCCATGGTTCCAACAAATTGCAAATAAAACTGTATGGAAACGATGAGC

>82024_82024_3_SKA1-NBAS_SKA1_chr18_47902288_ENST00000398452_NBAS_chr2_15449372_ENST00000281513_length(amino acids)=873AA_BP=19
MASSDLEQLCSHVNEKIGNIKKTLSLRNCVLLQLASEALPNDMTLALAYLLALPQVLDANRCFEKQSPSALSLQLAAYYYSLQIYARLAP
CFRDKCHPLYRADPKELIKMVTRHVTRHEHEAWPEDLISLTKQLHCYNERLLDFTQAQILQGLRKGVDVQRFTADDQYKRETILGLAETL
EESVYSIAISLAQRYSVSRWEVFMTHLEFLFTDSGLSTLEIENRAQDLHLFETLKTDPEAFHQHMVKYIYPTIGGFDHERLQYYFTLLEN
CGCADLGNCAIKPETHIRLLKKFKVVASGLNYKKLTDENMSPLEALEPVLSSQNILSISKLVPKIPEKDGQMLSPSSLYTIWLQKLFWTG
DPHLIKQVPGSSPEWLHAYDVCMKYFDRLHPGDLITVVDAVTFSPKAVTKLSVEARKEMTRKAIKTVKHFIEKPRKRNSEDEAQEAKDSK
VTYADTLNHLEKSLAHLETLSHSFILSLKNSEQETLQKYSHLYDLSRSEKEKLHDEAVAICLDGQPLAMIQQLLEVAVGPLDISPKDIVQ
SAIMKIISALSGGSADLGGPRDPLKVLEGVVAAVHASVDKGEELVSPEDLLEWLRPFCADDAWPVRPRIHVLQILGQSFHLTEEDSKLLV
FFRTEAILKASWPQRQVDIADIENEENRYCLFMELLESSHHEAEFQHLVLLLQAWPPMKSEYVITNNPWVRLATVMLTRCTMENKEGLGN
EVLKMCRSLYNTKQMLPAEGVKELCLLLLNQSLLLPSLKLLLESRDEHLHEMALEQITAVTTVNDSNCDQELLSLLLDAKLLVKCVSTPF

--------------------------------------------------------------
>82024_82024_4_SKA1-NBAS_SKA1_chr18_47902288_ENST00000398452_NBAS_chr2_15449372_ENST00000441750_length(transcript)=2973nt_BP=299nt
ATGGATGTGCGCCTGCGCTGCGCTAGGGCGCGGCGGGCGGTTTGAATTTTGCTTACAGAGTCCCGTCTCACCATCCTGGGCTTCCAACGG
AGACTGCGGTATCCGCAGCTGGAGACCCAGCGGCGAGTAGCCTTTTGCTCCCGGACGGACTTGAGGTTGGAGTCTGTGTGTTGGGGACCC
TGCCTTTGGAAGCGCCCGAGAGGCTTAAAGGATGGCCTCGTCAGATCTGGAACAATTATGCTCTCATGTTAATGAAAAGATTGGCAATAT
TAAGAAAACCTTATCATTAAGAAACTGTGTTCTCTTGCAACTAGCAAGTGAAGCCTTGCCAAATGACATGACCTTGGCTCTTGCTTACCT
TCTTGCCTTACCACAAGTGTTAGATGCTAACCGGTGCTTTGAAAAGCAGTCCCCCTCTGCATTATCTCTCCAGCTGGCAGCGTATTACTA
TAGCCTCCAGATCTATGCCCGATTGGCCCCATGTTTCAGGGACAAGTGCCATCCTCTTTACAGGGCTGATCCCAAAGAACTAATCAAGAT
GGTCACCAGGCATGTGACTCGACATGAGCACGAAGCCTGGCCTGAAGACCTTATTTCACTGACCAAGCAGTTACACTGCTACAATGAACG
TCTCCTGGATTTCACTCAGGCGCAGATCCTTCAGGGCCTTCGGAAGGGTGTGGACGTGCAGCGGTTTACTGCAGATGACCAGTATAAAAG
GGAAACTATCCTTGGTCTGGCAGAAACTCTAGAGGAAAGCGTCTACAGCATTGCTATTTCTCTGGCACAACGTTACAGTGTCTCCCGCTG
GGAAGTTTTTATGACCCATTTGGAGTTCCTCTTCACGGACAGTGGTTTGTCCACACTAGAAATTGAAAATAGAGCCCAAGACCTTCATCT
CTTTGAGACTTTGAAGACTGATCCAGAAGCCTTTCACCAGCACATGGTCAAGTATATTTACCCTACTATTGGTGGCTTTGATCACGAAAG
GCTGCAGTATTATTTCACTCTTCTGGAAAACTGTGGCTGTGCAGATTTGGGGAACTGTGCCATTAAACCAGAAACCCACATTCGACTGCT
GAAGAAGTTTAAGGTTGTTGCATCAGGTCTTAATTACAAAAAGCTGACAGATGAAAACATGAGTCCTCTTGAAGCATTGGAGCCAGTTCT
TTCAAGTCAAAATATCTTGTCTATTTCCAAACTTGTTCCCAAAATCCCTGAAAAGGATGGACAGATGCTTTCCCCAAGCTCTCTGTACAC
CATCTGGTTACAGAAGTTGTTCTGGACTGGAGACCCTCATCTCATTAAACAAGTCCCAGGCTCTTCACCGGAGTGGCTTCATGCCTATGA
TGTCTGCATGAAGTACTTTGATCGTCTCCACCCAGGTGACCTCATCACTGTGGTAGATGCAGTTACATTTTCTCCAAAAGCTGTGACCAA
GCTGTCTGTGGAAGCCCGTAAAGAGATGACTAGAAAGGCTATTAAGACAGTCAAACATTTTATTGAGAAGCCAAGGAAAAGAAACTCAGA
AGACGAAGCTCAAGAAGCTAAGGATTCTAAAGTTACCTATGCAGATACTTTGAATCATCTGGAGAAATCACTTGCCCACCTGGAAACCCT
GAGCCACAGCTTCATCCTTTCTCTGAAGAATAGTGAGCAGGAAACACTGCAAAAATACAGTCACCTCTATGATCTGTCCCGATCAGAAAA
AGAGAAACTTCATGATGAAGCTGTGGCTATTTGTTTAGATGGTCAGCCTCTAGCAATGATTCAGCAGCTGCTAGAGGTGGCAGTTGGCCC
TCTTGACATCTCACCCAAGGATATAGTGCAGAGTGCAATCATGAAAATAATTTCTGCATTGAGTGGTGGCAGTGCTGACCTTGGTGGGCC
AAGGGACCCACTGAAGGTCCTGGAAGGTGTTGTTGCAGCAGTCCACGCCAGTGTGGACAAGGGTGAGGAGCTGGTTTCACCTGAGGACCT
GCTGGAGTGGCTGCGGCCTTTCTGTGCTGATGACGCCTGGCCGGTGCGGCCCCGCATTCACGTGCTGCAGATTTTGGGGCAATCATTTCA
CCTGACTGAGGAGGACAGCAAGCTCCTCGTGTTCTTTAGAACTGAAGCCATTCTCAAAGCCTCCTGGCCCCAGAGACAGGTAGACATAGC
TGACATTGAGAATGAAGAGAACCGCTACTGTCTATTCATGGAACTCCTGGAATCTAGTCACCACGAGGCTGAATTTCAGCACTTGGTTTT
ACTTTTGCAAGCTTGGCCACCTATGAAAAGTGAATATGTCATAACCAATAATCCATGGGTGAGACTAGCTACAGTGATGCTAACCAGATG
TACGATGGAGAACAAGGAAGGATTGGGGAATGAAGTTTTGAAAATGTGTCGCTCTTTGTATAACACCAAGCAGATGCTGCCTGCAGAGGG
TGTGAAGGAGCTGTGTCTGCTGCTGCTTAACCAGTCCCTCCTGCTTCCATCTCTGAAACTTCTCCTCGAGAGCCGAGATGAGCATCTGCA
CGAGATGGCACTGGAGCAAATCACGGCAGTCACTACGGTGAATGATTCCAATTGTGACCAAGAACTTCTTTCCCTGCTCCTGGATGCCAA
GCTGCTGGTGAAGTGTGTCTCCACTCCCTTCTATCCACGTATTGTTGACCACCTCTTGGCTAGCCTCCAGCAAGGGCGCTGGGATGCAGA
GGAGCTGGGCAGACACCTGCGGGAGGCCGGCCATGAAGCCGAAGCCGGGTCTCTCCTTCTGGCCGTGAGGGGGACTCACCAGGCCTTCAG
AACCTTCAGTACAGCCCTCCGCGCAGCACAGCACTGGGTGTGAGGGCCACCTGTGGCCCTGCTCCTTAGCAGAAAAAGCATCTGGAGTTG
AATGCTGTTCCCAGAAGCAACATGTGTATCTGCCGATTGTTCTCCATGGTTCCAACAAATTGCAAATAAAACTGTATGGAAACGATGAGC

>82024_82024_4_SKA1-NBAS_SKA1_chr18_47902288_ENST00000398452_NBAS_chr2_15449372_ENST00000441750_length(amino acids)=873AA_BP=19
MASSDLEQLCSHVNEKIGNIKKTLSLRNCVLLQLASEALPNDMTLALAYLLALPQVLDANRCFEKQSPSALSLQLAAYYYSLQIYARLAP
CFRDKCHPLYRADPKELIKMVTRHVTRHEHEAWPEDLISLTKQLHCYNERLLDFTQAQILQGLRKGVDVQRFTADDQYKRETILGLAETL
EESVYSIAISLAQRYSVSRWEVFMTHLEFLFTDSGLSTLEIENRAQDLHLFETLKTDPEAFHQHMVKYIYPTIGGFDHERLQYYFTLLEN
CGCADLGNCAIKPETHIRLLKKFKVVASGLNYKKLTDENMSPLEALEPVLSSQNILSISKLVPKIPEKDGQMLSPSSLYTIWLQKLFWTG
DPHLIKQVPGSSPEWLHAYDVCMKYFDRLHPGDLITVVDAVTFSPKAVTKLSVEARKEMTRKAIKTVKHFIEKPRKRNSEDEAQEAKDSK
VTYADTLNHLEKSLAHLETLSHSFILSLKNSEQETLQKYSHLYDLSRSEKEKLHDEAVAICLDGQPLAMIQQLLEVAVGPLDISPKDIVQ
SAIMKIISALSGGSADLGGPRDPLKVLEGVVAAVHASVDKGEELVSPEDLLEWLRPFCADDAWPVRPRIHVLQILGQSFHLTEEDSKLLV
FFRTEAILKASWPQRQVDIADIENEENRYCLFMELLESSHHEAEFQHLVLLLQAWPPMKSEYVITNNPWVRLATVMLTRCTMENKEGLGN
EVLKMCRSLYNTKQMLPAEGVKELCLLLLNQSLLLPSLKLLLESRDEHLHEMALEQITAVTTVNDSNCDQELLSLLLDAKLLVKCVSTPF

--------------------------------------------------------------
>82024_82024_5_SKA1-NBAS_SKA1_chr18_47902288_ENST00000417656_NBAS_chr2_15449372_ENST00000281513_length(transcript)=2924nt_BP=251nt
GATGTGCGCCTGCGCTGCGCTAGGGCGCGGCGGGCGGTTTGAATTTTGCTTACAGAGTCCCGTCTCACCATCCTGGGCTTCCAACGGAGA
CTGCGGTATCCGCAGCTGGAGACCCAGCGGCGAGTAGCCTTTTGCTCCCGGACGGACTTGAGAGGCTTAAAGGATGGCCTCGTCAGATCT
GGAACAATTATGCTCTCATGTTAATGAAAAGATTGGCAATATTAAGAAAACCTTATCATTAAGAAACTGTGTTCTCTTGCAACTAGCAAG
TGAAGCCTTGCCAAATGACATGACCTTGGCTCTTGCTTACCTTCTTGCCTTACCACAAGTGTTAGATGCTAACCGGTGCTTTGAAAAGCA
GTCCCCCTCTGCATTATCTCTCCAGCTGGCAGCGTATTACTATAGCCTCCAGATCTATGCCCGATTGGCCCCATGTTTCAGGGACAAGTG
CCATCCTCTTTACAGGGCTGATCCCAAAGAACTAATCAAGATGGTCACCAGGCATGTGACTCGACATGAGCACGAAGCCTGGCCTGAAGA
CCTTATTTCACTGACCAAGCAGTTACACTGCTACAATGAACGTCTCCTGGATTTCACTCAGGCGCAGATCCTTCAGGGCCTTCGGAAGGG
TGTGGACGTGCAGCGGTTTACTGCAGATGACCAGTATAAAAGGGAAACTATCCTTGGTCTGGCAGAAACTCTAGAGGAAAGCGTCTACAG
CATTGCTATTTCTCTGGCACAACGTTACAGTGTCTCCCGCTGGGAAGTTTTTATGACCCATTTGGAGTTCCTCTTCACGGACAGTGGTTT
GTCCACACTAGAAATTGAAAATAGAGCCCAAGACCTTCATCTCTTTGAGACTTTGAAGACTGATCCAGAAGCCTTTCACCAGCACATGGT
CAAGTATATTTACCCTACTATTGGTGGCTTTGATCACGAAAGGCTGCAGTATTATTTCACTCTTCTGGAAAACTGTGGCTGTGCAGATTT
GGGGAACTGTGCCATTAAACCAGAAACCCACATTCGACTGCTGAAGAAGTTTAAGGTTGTTGCATCAGGTCTTAATTACAAAAAGCTGAC
AGATGAAAACATGAGTCCTCTTGAAGCATTGGAGCCAGTTCTTTCAAGTCAAAATATCTTGTCTATTTCCAAACTTGTTCCCAAAATCCC
TGAAAAGGATGGACAGATGCTTTCCCCAAGCTCTCTGTACACCATCTGGTTACAGAAGTTGTTCTGGACTGGAGACCCTCATCTCATTAA
ACAAGTCCCAGGCTCTTCACCGGAGTGGCTTCATGCCTATGATGTCTGCATGAAGTACTTTGATCGTCTCCACCCAGGTGACCTCATCAC
TGTGGTAGATGCAGTTACATTTTCTCCAAAAGCTGTGACCAAGCTGTCTGTGGAAGCCCGTAAAGAGATGACTAGAAAGGCTATTAAGAC
AGTCAAACATTTTATTGAGAAGCCAAGGAAAAGAAACTCAGAAGACGAAGCTCAAGAAGCTAAGGATTCTAAAGTTACCTATGCAGATAC
TTTGAATCATCTGGAGAAATCACTTGCCCACCTGGAAACCCTGAGCCACAGCTTCATCCTTTCTCTGAAGAATAGTGAGCAGGAAACACT
GCAAAAATACAGTCACCTCTATGATCTGTCCCGATCAGAAAAAGAGAAACTTCATGATGAAGCTGTGGCTATTTGTTTAGATGGTCAGCC
TCTAGCAATGATTCAGCAGCTGCTAGAGGTGGCAGTTGGCCCTCTTGACATCTCACCCAAGGATATAGTGCAGAGTGCAATCATGAAAAT
AATTTCTGCATTGAGTGGTGGCAGTGCTGACCTTGGTGGGCCAAGGGACCCACTGAAGGTCCTGGAAGGTGTTGTTGCAGCAGTCCACGC
CAGTGTGGACAAGGGTGAGGAGCTGGTTTCACCTGAGGACCTGCTGGAGTGGCTGCGGCCTTTCTGTGCTGATGACGCCTGGCCGGTGCG
GCCCCGCATTCACGTGCTGCAGATTTTGGGGCAATCATTTCACCTGACTGAGGAGGACAGCAAGCTCCTCGTGTTCTTTAGAACTGAAGC
CATTCTCAAAGCCTCCTGGCCCCAGAGACAGGTAGACATAGCTGACATTGAGAATGAAGAGAACCGCTACTGTCTATTCATGGAACTCCT
GGAATCTAGTCACCACGAGGCTGAATTTCAGCACTTGGTTTTACTTTTGCAAGCTTGGCCACCTATGAAAAGTGAATATGTCATAACCAA
TAATCCATGGGTGAGACTAGCTACAGTGATGCTAACCAGATGTACGATGGAGAACAAGGAAGGATTGGGGAATGAAGTTTTGAAAATGTG
TCGCTCTTTGTATAACACCAAGCAGATGCTGCCTGCAGAGGGTGTGAAGGAGCTGTGTCTGCTGCTGCTTAACCAGTCCCTCCTGCTTCC
ATCTCTGAAACTTCTCCTCGAGAGCCGAGATGAGCATCTGCACGAGATGGCACTGGAGCAAATCACGGCAGTCACTACGGTGAATGATTC
CAATTGTGACCAAGAACTTCTTTCCCTGCTCCTGGATGCCAAGCTGCTGGTGAAGTGTGTCTCCACTCCCTTCTATCCACGTATTGTTGA
CCACCTCTTGGCTAGCCTCCAGCAAGGGCGCTGGGATGCAGAGGAGCTGGGCAGACACCTGCGGGAGGCCGGCCATGAAGCCGAAGCCGG
GTCTCTCCTTCTGGCCGTGAGGGGGACTCACCAGGCCTTCAGAACCTTCAGTACAGCCCTCCGCGCAGCACAGCACTGGGTGTGAGGGCC
ACCTGTGGCCCTGCTCCTTAGCAGAAAAAGCATCTGGAGTTGAATGCTGTTCCCAGAAGCAACATGTGTATCTGCCGATTGTTCTCCATG

>82024_82024_5_SKA1-NBAS_SKA1_chr18_47902288_ENST00000417656_NBAS_chr2_15449372_ENST00000281513_length(amino acids)=873AA_BP=19
MASSDLEQLCSHVNEKIGNIKKTLSLRNCVLLQLASEALPNDMTLALAYLLALPQVLDANRCFEKQSPSALSLQLAAYYYSLQIYARLAP
CFRDKCHPLYRADPKELIKMVTRHVTRHEHEAWPEDLISLTKQLHCYNERLLDFTQAQILQGLRKGVDVQRFTADDQYKRETILGLAETL
EESVYSIAISLAQRYSVSRWEVFMTHLEFLFTDSGLSTLEIENRAQDLHLFETLKTDPEAFHQHMVKYIYPTIGGFDHERLQYYFTLLEN
CGCADLGNCAIKPETHIRLLKKFKVVASGLNYKKLTDENMSPLEALEPVLSSQNILSISKLVPKIPEKDGQMLSPSSLYTIWLQKLFWTG
DPHLIKQVPGSSPEWLHAYDVCMKYFDRLHPGDLITVVDAVTFSPKAVTKLSVEARKEMTRKAIKTVKHFIEKPRKRNSEDEAQEAKDSK
VTYADTLNHLEKSLAHLETLSHSFILSLKNSEQETLQKYSHLYDLSRSEKEKLHDEAVAICLDGQPLAMIQQLLEVAVGPLDISPKDIVQ
SAIMKIISALSGGSADLGGPRDPLKVLEGVVAAVHASVDKGEELVSPEDLLEWLRPFCADDAWPVRPRIHVLQILGQSFHLTEEDSKLLV
FFRTEAILKASWPQRQVDIADIENEENRYCLFMELLESSHHEAEFQHLVLLLQAWPPMKSEYVITNNPWVRLATVMLTRCTMENKEGLGN
EVLKMCRSLYNTKQMLPAEGVKELCLLLLNQSLLLPSLKLLLESRDEHLHEMALEQITAVTTVNDSNCDQELLSLLLDAKLLVKCVSTPF

--------------------------------------------------------------
>82024_82024_6_SKA1-NBAS_SKA1_chr18_47902288_ENST00000417656_NBAS_chr2_15449372_ENST00000441750_length(transcript)=2925nt_BP=251nt
GATGTGCGCCTGCGCTGCGCTAGGGCGCGGCGGGCGGTTTGAATTTTGCTTACAGAGTCCCGTCTCACCATCCTGGGCTTCCAACGGAGA
CTGCGGTATCCGCAGCTGGAGACCCAGCGGCGAGTAGCCTTTTGCTCCCGGACGGACTTGAGAGGCTTAAAGGATGGCCTCGTCAGATCT
GGAACAATTATGCTCTCATGTTAATGAAAAGATTGGCAATATTAAGAAAACCTTATCATTAAGAAACTGTGTTCTCTTGCAACTAGCAAG
TGAAGCCTTGCCAAATGACATGACCTTGGCTCTTGCTTACCTTCTTGCCTTACCACAAGTGTTAGATGCTAACCGGTGCTTTGAAAAGCA
GTCCCCCTCTGCATTATCTCTCCAGCTGGCAGCGTATTACTATAGCCTCCAGATCTATGCCCGATTGGCCCCATGTTTCAGGGACAAGTG
CCATCCTCTTTACAGGGCTGATCCCAAAGAACTAATCAAGATGGTCACCAGGCATGTGACTCGACATGAGCACGAAGCCTGGCCTGAAGA
CCTTATTTCACTGACCAAGCAGTTACACTGCTACAATGAACGTCTCCTGGATTTCACTCAGGCGCAGATCCTTCAGGGCCTTCGGAAGGG
TGTGGACGTGCAGCGGTTTACTGCAGATGACCAGTATAAAAGGGAAACTATCCTTGGTCTGGCAGAAACTCTAGAGGAAAGCGTCTACAG
CATTGCTATTTCTCTGGCACAACGTTACAGTGTCTCCCGCTGGGAAGTTTTTATGACCCATTTGGAGTTCCTCTTCACGGACAGTGGTTT
GTCCACACTAGAAATTGAAAATAGAGCCCAAGACCTTCATCTCTTTGAGACTTTGAAGACTGATCCAGAAGCCTTTCACCAGCACATGGT
CAAGTATATTTACCCTACTATTGGTGGCTTTGATCACGAAAGGCTGCAGTATTATTTCACTCTTCTGGAAAACTGTGGCTGTGCAGATTT
GGGGAACTGTGCCATTAAACCAGAAACCCACATTCGACTGCTGAAGAAGTTTAAGGTTGTTGCATCAGGTCTTAATTACAAAAAGCTGAC
AGATGAAAACATGAGTCCTCTTGAAGCATTGGAGCCAGTTCTTTCAAGTCAAAATATCTTGTCTATTTCCAAACTTGTTCCCAAAATCCC
TGAAAAGGATGGACAGATGCTTTCCCCAAGCTCTCTGTACACCATCTGGTTACAGAAGTTGTTCTGGACTGGAGACCCTCATCTCATTAA
ACAAGTCCCAGGCTCTTCACCGGAGTGGCTTCATGCCTATGATGTCTGCATGAAGTACTTTGATCGTCTCCACCCAGGTGACCTCATCAC
TGTGGTAGATGCAGTTACATTTTCTCCAAAAGCTGTGACCAAGCTGTCTGTGGAAGCCCGTAAAGAGATGACTAGAAAGGCTATTAAGAC
AGTCAAACATTTTATTGAGAAGCCAAGGAAAAGAAACTCAGAAGACGAAGCTCAAGAAGCTAAGGATTCTAAAGTTACCTATGCAGATAC
TTTGAATCATCTGGAGAAATCACTTGCCCACCTGGAAACCCTGAGCCACAGCTTCATCCTTTCTCTGAAGAATAGTGAGCAGGAAACACT
GCAAAAATACAGTCACCTCTATGATCTGTCCCGATCAGAAAAAGAGAAACTTCATGATGAAGCTGTGGCTATTTGTTTAGATGGTCAGCC
TCTAGCAATGATTCAGCAGCTGCTAGAGGTGGCAGTTGGCCCTCTTGACATCTCACCCAAGGATATAGTGCAGAGTGCAATCATGAAAAT
AATTTCTGCATTGAGTGGTGGCAGTGCTGACCTTGGTGGGCCAAGGGACCCACTGAAGGTCCTGGAAGGTGTTGTTGCAGCAGTCCACGC
CAGTGTGGACAAGGGTGAGGAGCTGGTTTCACCTGAGGACCTGCTGGAGTGGCTGCGGCCTTTCTGTGCTGATGACGCCTGGCCGGTGCG
GCCCCGCATTCACGTGCTGCAGATTTTGGGGCAATCATTTCACCTGACTGAGGAGGACAGCAAGCTCCTCGTGTTCTTTAGAACTGAAGC
CATTCTCAAAGCCTCCTGGCCCCAGAGACAGGTAGACATAGCTGACATTGAGAATGAAGAGAACCGCTACTGTCTATTCATGGAACTCCT
GGAATCTAGTCACCACGAGGCTGAATTTCAGCACTTGGTTTTACTTTTGCAAGCTTGGCCACCTATGAAAAGTGAATATGTCATAACCAA
TAATCCATGGGTGAGACTAGCTACAGTGATGCTAACCAGATGTACGATGGAGAACAAGGAAGGATTGGGGAATGAAGTTTTGAAAATGTG
TCGCTCTTTGTATAACACCAAGCAGATGCTGCCTGCAGAGGGTGTGAAGGAGCTGTGTCTGCTGCTGCTTAACCAGTCCCTCCTGCTTCC
ATCTCTGAAACTTCTCCTCGAGAGCCGAGATGAGCATCTGCACGAGATGGCACTGGAGCAAATCACGGCAGTCACTACGGTGAATGATTC
CAATTGTGACCAAGAACTTCTTTCCCTGCTCCTGGATGCCAAGCTGCTGGTGAAGTGTGTCTCCACTCCCTTCTATCCACGTATTGTTGA
CCACCTCTTGGCTAGCCTCCAGCAAGGGCGCTGGGATGCAGAGGAGCTGGGCAGACACCTGCGGGAGGCCGGCCATGAAGCCGAAGCCGG
GTCTCTCCTTCTGGCCGTGAGGGGGACTCACCAGGCCTTCAGAACCTTCAGTACAGCCCTCCGCGCAGCACAGCACTGGGTGTGAGGGCC
ACCTGTGGCCCTGCTCCTTAGCAGAAAAAGCATCTGGAGTTGAATGCTGTTCCCAGAAGCAACATGTGTATCTGCCGATTGTTCTCCATG

>82024_82024_6_SKA1-NBAS_SKA1_chr18_47902288_ENST00000417656_NBAS_chr2_15449372_ENST00000441750_length(amino acids)=873AA_BP=19
MASSDLEQLCSHVNEKIGNIKKTLSLRNCVLLQLASEALPNDMTLALAYLLALPQVLDANRCFEKQSPSALSLQLAAYYYSLQIYARLAP
CFRDKCHPLYRADPKELIKMVTRHVTRHEHEAWPEDLISLTKQLHCYNERLLDFTQAQILQGLRKGVDVQRFTADDQYKRETILGLAETL
EESVYSIAISLAQRYSVSRWEVFMTHLEFLFTDSGLSTLEIENRAQDLHLFETLKTDPEAFHQHMVKYIYPTIGGFDHERLQYYFTLLEN
CGCADLGNCAIKPETHIRLLKKFKVVASGLNYKKLTDENMSPLEALEPVLSSQNILSISKLVPKIPEKDGQMLSPSSLYTIWLQKLFWTG
DPHLIKQVPGSSPEWLHAYDVCMKYFDRLHPGDLITVVDAVTFSPKAVTKLSVEARKEMTRKAIKTVKHFIEKPRKRNSEDEAQEAKDSK
VTYADTLNHLEKSLAHLETLSHSFILSLKNSEQETLQKYSHLYDLSRSEKEKLHDEAVAICLDGQPLAMIQQLLEVAVGPLDISPKDIVQ
SAIMKIISALSGGSADLGGPRDPLKVLEGVVAAVHASVDKGEELVSPEDLLEWLRPFCADDAWPVRPRIHVLQILGQSFHLTEEDSKLLV
FFRTEAILKASWPQRQVDIADIENEENRYCLFMELLESSHHEAEFQHLVLLLQAWPPMKSEYVITNNPWVRLATVMLTRCTMENKEGLGN
EVLKMCRSLYNTKQMLPAEGVKELCLLLLNQSLLLPSLKLLLESRDEHLHEMALEQITAVTTVNDSNCDQELLSLLLDAKLLVKCVSTPF

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SKA1-NBAS


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneNBASchr18:47902288chr2:15449372ENST0000028151337521_10351527.33333333333332372.0USE1L
TgeneNBASchr18:47902288chr2:15449372ENST0000044175035501_10351407.33333333333332252.0USE1L
TgeneNBASchr18:47902288chr2:15449372ENST0000028151337521036_23711527.33333333333332372.0ZW10 and RINT1
TgeneNBASchr18:47902288chr2:15449372ENST0000044175035501036_23711407.33333333333332252.0ZW10 and RINT1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SKA1-NBAS


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SKA1-NBAS


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource