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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SKAP1-PSMD11 (FusionGDB2 ID:82063)

Fusion Gene Summary for SKAP1-PSMD11

check button Fusion gene summary
Fusion gene informationFusion gene name: SKAP1-PSMD11
Fusion gene ID: 82063
HgeneTgene
Gene symbol

SKAP1

PSMD11

Gene ID

8631

5717

Gene namesrc kinase associated phosphoprotein 1proteasome 26S subunit, non-ATPase 11
SynonymsHEL-S-81p|SCAP1|SKAP55Rpn6|S9|p44.5
Cytomap

17q21.32

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionsrc kinase-associated phosphoprotein 1SKAP-55epididymis secretory sperm binding protein Li 81ppp55src family-associated phosphoprotein 1src kinase-associated phosphoprotein of 55 kDa26S proteasome non-ATPase regulatory subunit 1126S proteasome regulatory subunit 926S proteasome regulatory subunit RPN626S proteasome regulatory subunit S926S proteasome regulatory subunit p44.5proteasome (prosome, macropain) 26S subunit, non-ATPase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000336915, ENST00000584924, 
ENST00000261712, ENST00000457654, 
Fusion gene scores* DoF score26 X 10 X 10=260016 X 18 X 7=2016
# samples 3521
** MAII scorelog2(35/2600*10)=-2.89308479608349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(21/2016*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SKAP1 [Title/Abstract] AND PSMD11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSKAP1(46423267)-PSMD11(30773963), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSKAP1

GO:0002821

positive regulation of adaptive immune response

12652296

HgeneSKAP1

GO:0033625

positive regulation of integrin activation

12652296

HgeneSKAP1

GO:0034116

positive regulation of heterotypic cell-cell adhesion

12652296

HgeneSKAP1

GO:0045944

positive regulation of transcription by RNA polymerase II

11909961

HgeneSKAP1

GO:1903039

positive regulation of leukocyte cell-cell adhesion

12652296


check buttonFusion gene breakpoints across SKAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PSMD11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-XD-AAUI-01ASKAP1chr17

46423267

-PSMD11chr17

30773963

+
ChimerDB4PAADTCGA-XD-AAUISKAP1chr17

46423267

-PSMD11chr17

30773963

+


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Fusion Gene ORF analysis for SKAP1-PSMD11

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000336915ENST00000261712SKAP1chr17

46423267

-PSMD11chr17

30773963

+
In-frameENST00000336915ENST00000457654SKAP1chr17

46423267

-PSMD11chr17

30773963

+
In-frameENST00000584924ENST00000261712SKAP1chr17

46423267

-PSMD11chr17

30773963

+
In-frameENST00000584924ENST00000457654SKAP1chr17

46423267

-PSMD11chr17

30773963

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000336915SKAP1chr1746423267-ENST00000261712PSMD11chr1730773963+4094350701527485
ENST00000336915SKAP1chr1746423267-ENST00000457654PSMD11chr1730773963+2368350701527485
ENST00000584924SKAP1chr1746423267-ENST00000261712PSMD11chr1730773963+4123379991556485
ENST00000584924SKAP1chr1746423267-ENST00000457654PSMD11chr1730773963+2397379991556485

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336915ENST00000261712SKAP1chr1746423267-PSMD11chr1730773963+0.000693390.99930656
ENST00000336915ENST00000457654SKAP1chr1746423267-PSMD11chr1730773963+0.0024128280.9975872
ENST00000584924ENST00000261712SKAP1chr1746423267-PSMD11chr1730773963+0.0006944970.9993055
ENST00000584924ENST00000457654SKAP1chr1746423267-PSMD11chr1730773963+0.0024296880.99757034

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Fusion Genomic Features for SKAP1-PSMD11


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SKAP1chr1746423266-PSMD11chr1730773962+3.10E-121
SKAP1chr1746423266-PSMD11chr1730773962+3.10E-121
SKAP1chr1746423266-PSMD11chr1730773962+3.10E-121
SKAP1chr1746423266-PSMD11chr1730773962+3.10E-121

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SKAP1-PSMD11


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:46423267/chr17:30773963)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePSMD11chr17:46423267chr17:30773963ENST00000261712014224_392301160.3333333333333DomainPCI
TgenePSMD11chr17:46423267chr17:30773963ENST00000457654013224_39230423.0DomainPCI

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSKAP1chr17:46423267chr17:30773963ENST00000336915-413220_23093448.0Compositional biasNote=Poly-Glu
HgeneSKAP1chr17:46423267chr17:30773963ENST00000584924-412220_23093360.0Compositional biasNote=Poly-Glu
HgeneSKAP1chr17:46423267chr17:30773963ENST00000336915-413107_21093448.0DomainPH
HgeneSKAP1chr17:46423267chr17:30773963ENST00000336915-413294_35593448.0DomainSH3
HgeneSKAP1chr17:46423267chr17:30773963ENST00000584924-412107_21093360.0DomainPH
HgeneSKAP1chr17:46423267chr17:30773963ENST00000584924-412294_35593360.0DomainSH3


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Fusion Gene Sequence for SKAP1-PSMD11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>82063_82063_1_SKAP1-PSMD11_SKAP1_chr17_46423267_ENST00000336915_PSMD11_chr17_30773963_ENST00000261712_length(transcript)=4094nt_BP=350nt
GTCGCCTTCCAGCCCGTCCGCCTCCCGACCAGGGCCCGCGCCCCGTCCCGCCTCTCTCCCGCCCAGCCAAATGCAGGCCGCCGCCCTCCC
TGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTCAGCGCTGTTGCAAGGGATCA
CAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGGGGAGACATTGGACAGGACAG
CTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTATCAGGATGAGGTGAAGCGTGA
CATTCAGGAAAACGATGAAGAGGCAGTGCAAGTCAAAGAGCAGAGCATCCTGGAACTGGGATCTCTCCTGGCAAAGACTGGACAAGCTGC
AGAGCTTGGAGGACTCCTGAAGTATGTACGACCCTTCTTGAATTCCATCAGCAAGGCTAAAGCAGCTCGCCTGGTCCGATCTCTTCTTGA
TCTGTTTCTTGATATGGAAGCAGCTACAGGGCAGGAGGTCGAGCTGTGTTTAGAGTGCATCGAATGGGCCAAGTCAGAGAAAAGAACTTT
CTTACGCCAAGCTTTGGAGGCAAGACTGGTGTCTTTGTACTTTGATACCAAGAGGTACCAGGAAGCATTGCATTTGGGTTCTCAGCTGCT
GCGGGAGTTGAAAAAGATGGACGACAAAGCTCTTTTGGTGGAAGTACAGCTTTTAGAAAGCAAAACATACCATGCCCTGAGCAACCTGCC
GAAAGCCCGAGCTGCCTTAACTTCTGCTCGAACCACAGCAAATGCCATCTACTGCCCCCCTAAATTGCAGGCCACCTTGGACATGCAGTC
GGGTATTATCCATGCAGCAGAAGAGAAGGACTGGAAAACTGCGTACTCATACTTCTATGAGGCATTTGAGGGTTATGACTCCATCGACAG
CCCCAAGGCCATCACATCTCTGAAGTACATGTTGCTGTGCAAAATCATGCTCAACACCCCAGAAGATGTCCAGGCTTTGGTGAGCGGGAA
GCTTGCACTTCGGTATGCAGGGAGGCAGACAGAAGCATTAAAATGCGTGGCTCAGGCTAGCAAGAACAGATCACTGGCAGATTTTGAAAA
GGCTCTGACAGATTACCGGGCAGAGCTCCGGGATGACCCAATCATCAGCACACACTTGGCCAAGTTGTATGATAACTTACTAGAACAGAA
TCTGATCCGAGTCATTGAGCCTTTTTCCAGAGTACAGATTGAACACATATCTAGTCTCATCAAACTCTCCAAGGCCGACGTGGAAAGGAA
ATTATCACAGATGATTCTTGACAAGAAATTTCATGGGATTTTGGACCAGGGGGAGGGTGTCCTGATTATTTTCGATGAACCCCCAGTAGA
TAAAACTTACGAAGCTGCTCTGGAAACAATTCAGAACATGAGCAAAGTAGTGGATTCCCTCTACAACAAAGCCAAGAAACTGACATAGAG
TTGGATCTGTAGCGGTCCTTTGGAGAGTGTGTGTGGCGGGAGAGTGAAACCTTGGGGGAAAATGCTAGGAGATTCTTTTTTCTTTTTGTT
CTACTTTTCGCTCGGAAAGTTTTTAAATCCTCATTTGGTGCATCTGTATTCCAGCCAATAGGTGTGCCAGTTTTCATGTAATCTTTACTG
GCCCAACTTGGGAGTGGGGAAATTGCTTAAAAAAAAAGAAAAAGAAAAAAAAAAAGATTATTCTAAATAAAAGGAAAAAGGCTTACACTA
CCTAAAGCTGTGCTCTCTGCCTCCTGGGAGAGGGCCGCAAAGCCAGGCACCCCGCCAACCACTGGGGGTCCTAATCCACCTGCTGGGCAT
CACCTCTCCTCCTCCTCAGAATTGGGTGTTTGCTGACCATCAAAAGCAATGACTTTTTATTCTGTTTGTACTGAACCAAAACAAACAACT
GTGTATAGACTGCTGTTTTCTTTTTTATTTGAAATGAGGCATTTTGGTGTTCTTTCCCCTACCATACGGCCTGTCTGCCCTTCCCTCCCC
ACATTGGCTCCAGCAGAGTAGCCGAAGGTCCTGCCGCCGCCGCCACCACCACCACCACTGCAGCAACAACAGCAGCAGCAGCAGCAGCGC
CTGCATAGCTCCACTCTGACCTGTGAAGGAATGGGGATGAGGCCAGGAGCTAGTGTCTACCACGGCCACACAGGGAGCAGTGTGGGCCCT
TAGCCCCCAAGGGGCCTGCTATGCATGTGGCTTTTTTTTTTTTTTTAAACACAGTAAACTAGATTAGTCGTCAGTGTTTTAATTGCCCCT
CTTCTCCTCTCCTGCATTCCTCTCCTCTCTTCTTTCCTCTCTGTCCCTTCTCTTTCCCCTCTCAACCAGGAGACCATCATGTCTCTCTGC
CTTCCTCCTCTCCCCTCCAGGGGAGTCAGGCTGTCTGTGAAAGCCATGAGCTTCTCTCCCTCTCCCACTCCTCCTCTCCTACTTTCAGAT
GGATTTATTCCTTTTTTAAACAATGAACATCGGAAATGAGACTGTGGGGTGTGGTTTCTCTCTCTCTTTTTTTTTTAATTTTCTTTGTTG
GGTTTTTGAGCAACCTCATGTCCCCTTCCCAGGGAGCTTTTTAATTTACCTCTTAGAACTCAAGTGGATGGGAAGTAGAGCACTATGTGT
CAGTATGCTTTGTTTTCTGACACGATTACACAGCGAGGCTTTAATGCCATTTGGGTAGGTGAGCTTCTGCACTTCTGTTGTGCTGAACTG
TATTTTCTTCTCTCATCTCCTCTTTGTCTTTTTCTCTTTTCCTCTCCTTCCTGCCTTCTTCTGCTGGCCTCCTTTTCTCTTTCTTTACCT
TCCTTGGATTATCCTTCCAGGTTTTCATAATAAATTTATATTTTGTAAAAGGATTTTGTTGTACCAGGTTTTGCATCCTCACTGAATCTG
ACTGGCTTTTATTTTCCTCTCCAAAATCAGGTTTTTGTTCTCAACATCTTTCCCCATCATGTCTAGTCACTGTTTTGGTTTTGGCACCAT
CAGTATCAAATGTACAAACGGTTCTTGCTAACCAACACCAGGTATATCTGATGTTCAGATGAGTTCCAATAAAAATAATTTTTTTTTTTT
TCAAAAGGTGTCTTTTTCTTGAGTGCTGGAGGGCTTCCAAGCAAGTCCAGACAGCTCTGTGTGGCCCCACACTAGTCTAGCTCTCATCTG
GCCAAAGCTGTTATCTCATTTGTGTAATGGGAGTCCTTAAGGTAAATTTGGGGTCCAAACTTGGAGGGCTTTGGGGGCAAGAAAGTTGGT
GTGTGAGTTCTGAGGTTGGAAATGAGTTCAGGTGTCTTCTTCCAGGGCAGCATGGTCCAGTGAGCACATGTAAGTTTGGGCAGTAGATCC
TCTGAGCCTACTTTCTCTTCTACTCAGTGAGGATGCTGCTTCCTTGGCAGGTGATTGTGATGTGAAGCTTAGTAAGTCATAGACGTGCAG
GTGTCTGGAGAGTCCTGACATGCAGTTGTGGTTTCGTTTCCTTTTGGAATCTTCAAAGGCAGCGATTTTCATATTGCCTCACACCCTGGC
GGGGGCGGGGGGCTCTGGGACCACTGGGGGACCTGCTAAATCCTCTTCAGTCTGAGCAGTTCAGCCATTGTCAGTTTTAGTATTGTGTCT
CTGTATTTCACTTGCAGAAAGAGCTTTGCTTCTATAAAGGACTTTAAAAAGTACTCCAAAGAGATCTAGTTTTGGAGTAGAGGGGAGATG
TTTTCTCAAACTTAGGGCAGTCCTGAGATGCTCAGGCAGTAGCCCTTTTCTCAGTTCCCTTTGCGGGTCTTGGTCAGATGATGCCCTCTA
GACCCGTGCTGTCCAATATGTAGCCGCTAGCCATGTGCAGCTGTCAGGCCCTTGCAACGTGGCTGGTTCGAGCTGTGATACACTGCAAGT
GTAAACACAAACCAGACTTCGAAGGCTTAGTATGATAACAAAAGAAAAGGAGTGTAAAATATGTCAATAACTTTTTTATATATGTGTTGA

>82063_82063_1_SKAP1-PSMD11_SKAP1_chr17_46423267_ENST00000336915_PSMD11_chr17_30773963_ENST00000261712_length(amino acids)=485AA_BP=93
MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDY
QDEVKRDIQENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWA
KSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKLQ
ATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNR
SLADFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLII

--------------------------------------------------------------
>82063_82063_2_SKAP1-PSMD11_SKAP1_chr17_46423267_ENST00000336915_PSMD11_chr17_30773963_ENST00000457654_length(transcript)=2368nt_BP=350nt
GTCGCCTTCCAGCCCGTCCGCCTCCCGACCAGGGCCCGCGCCCCGTCCCGCCTCTCTCCCGCCCAGCCAAATGCAGGCCGCCGCCCTCCC
TGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTCAGCGCTGTTGCAAGGGATCA
CAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGGGGAGACATTGGACAGGACAG
CTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTATCAGGATGAGGTGAAGCGTGA
CATTCAGGAAAACGATGAAGAGGCAGTGCAAGTCAAAGAGCAGAGCATCCTGGAACTGGGATCTCTCCTGGCAAAGACTGGACAAGCTGC
AGAGCTTGGAGGACTCCTGAAGTATGTACGACCCTTCTTGAATTCCATCAGCAAGGCTAAAGCAGCTCGCCTGGTCCGATCTCTTCTTGA
TCTGTTTCTTGATATGGAAGCAGCTACAGGGCAGGAGGTCGAGCTGTGTTTAGAGTGCATCGAATGGGCCAAGTCAGAGAAAAGAACTTT
CTTACGCCAAGCTTTGGAGGCAAGACTGGTGTCTTTGTACTTTGATACCAAGAGGTACCAGGAAGCATTGCATTTGGGTTCTCAGCTGCT
GCGGGAGTTGAAAAAGATGGACGACAAAGCTCTTTTGGTGGAAGTACAGCTTTTAGAAAGCAAAACATACCATGCCCTGAGCAACCTGCC
GAAAGCCCGAGCTGCCTTAACTTCTGCTCGAACCACAGCAAATGCCATCTACTGCCCCCCTAAATTGCAGGCCACCTTGGACATGCAGTC
GGGTATTATCCATGCAGCAGAAGAGAAGGACTGGAAAACTGCGTACTCATACTTCTATGAGGCATTTGAGGGTTATGACTCCATCGACAG
CCCCAAGGCCATCACATCTCTGAAGTACATGTTGCTGTGCAAAATCATGCTCAACACCCCAGAAGATGTCCAGGCTTTGGTGAGCGGGAA
GCTTGCACTTCGGTATGCAGGGAGGCAGACAGAAGCATTAAAATGCGTGGCTCAGGCTAGCAAGAACAGATCACTGGCAGATTTTGAAAA
GGCTCTGACAGATTACCGGGCAGAGCTCCGGGATGACCCAATCATCAGCACACACTTGGCCAAGTTGTATGATAACTTACTAGAACAGAA
TCTGATCCGAGTCATTGAGCCTTTTTCCAGAGTACAGATTGAACACATATCTAGTCTCATCAAACTCTCCAAGGCCGACGTGGAAAGGAA
ATTATCACAGATGATTCTTGACAAGAAATTTCATGGGATTTTGGACCAGGGGGAGGGTGTCCTGATTATTTTCGATGAACCCCCAGTAGA
TAAAACTTACGAAGCTGCTCTGGAAACAATTCAGAACATGAGCAAAGTAGTGGATTCCCTCTACAACAAAGCCAAGAAACTGACATAGGT
GAGTGCTGGCTTCAGGACCCCAGGGCTGGGCAGCTCTGTCTTCTGCGTGTCGAGACTGAAAACCTCCTCCTGGTGTCCTCATGGCTTCCT
GATTGACACTGCTCTGTCTTCTCTTGCAGAGTTGGATCTGTAGCGGTCCTTTGGAGAGTGTGTGTGGCGGGAGAGTGAAACCTTGGGGGA
AAATGCTAGGAGATTCTTTTTTCTTTTTGTTCTACTTTTCGCTCGGAAAGTTTTTAAATCCTCATTTGGTGCATCTGTATTCCAGCCAAT
AGGTGTGCCAGTTTTCATGTAATCTTTACTGGCCCAACTTGGGAGTGGGGAAATTGCTTAAAAAAAAAGAAAAAGAAAAAAAAAAAGATT
ATTCTAAATAAAAGGAAAAAGGCTTACACTACCTAAAGCTGTGCTCTCTGCCTCCTGGGAGAGGGCCGCAAAGCCAGGCACCCCGCCAAC
CACTGGGGGTCCTAATCCACCTGCTGGGCATCACCTCTCCTCCTCCTCAGAATTGGGTGTTTGCTGACCATCAAAAGCAATGACTTTTTA
TTCTGTTTGTACTGAACCAAAACAAACAACTGTGTATAGACTGCTGTTTTCTTTTTTATTTGAAATGAGGCATTTTGGTGTTCTTTCCCC
TACCATACGGCCTGTCTGCCCTTCCCTCCCCACATTGGCTCCAGCAGAGTAGCCGAAGGTCCTGCCGCCGCCGCCACCACCACCACCACT
GCAGCAACAACAGCAGCAGCAGCAGCAGCGCCTGCATAGCTCCACTCTGACCTGTGAAGGAATGGGGATGAGGCCAGGAGCTAGTGTCTA

>82063_82063_2_SKAP1-PSMD11_SKAP1_chr17_46423267_ENST00000336915_PSMD11_chr17_30773963_ENST00000457654_length(amino acids)=485AA_BP=93
MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDY
QDEVKRDIQENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWA
KSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKLQ
ATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNR
SLADFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLII

--------------------------------------------------------------
>82063_82063_3_SKAP1-PSMD11_SKAP1_chr17_46423267_ENST00000584924_PSMD11_chr17_30773963_ENST00000261712_length(transcript)=4123nt_BP=379nt
GAGGTACAGGTGCCTCGCGGTGCAGCCGGGTCGCCTTCCAGCCCGTCCGCCTCCCGACCAGGGCCCGCGCCCCGTCCCGCCTCTCTCCCG
CCCAGCCAAATGCAGGCCGCCGCCCTCCCTGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAAT
GAGAACCTCAGCGCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAG
CCCCAAGGGGGAGACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTG
TCAGATTATCAGGATGAGGTGAAGCGTGACATTCAGGAAAACGATGAAGAGGCAGTGCAAGTCAAAGAGCAGAGCATCCTGGAACTGGGA
TCTCTCCTGGCAAAGACTGGACAAGCTGCAGAGCTTGGAGGACTCCTGAAGTATGTACGACCCTTCTTGAATTCCATCAGCAAGGCTAAA
GCAGCTCGCCTGGTCCGATCTCTTCTTGATCTGTTTCTTGATATGGAAGCAGCTACAGGGCAGGAGGTCGAGCTGTGTTTAGAGTGCATC
GAATGGGCCAAGTCAGAGAAAAGAACTTTCTTACGCCAAGCTTTGGAGGCAAGACTGGTGTCTTTGTACTTTGATACCAAGAGGTACCAG
GAAGCATTGCATTTGGGTTCTCAGCTGCTGCGGGAGTTGAAAAAGATGGACGACAAAGCTCTTTTGGTGGAAGTACAGCTTTTAGAAAGC
AAAACATACCATGCCCTGAGCAACCTGCCGAAAGCCCGAGCTGCCTTAACTTCTGCTCGAACCACAGCAAATGCCATCTACTGCCCCCCT
AAATTGCAGGCCACCTTGGACATGCAGTCGGGTATTATCCATGCAGCAGAAGAGAAGGACTGGAAAACTGCGTACTCATACTTCTATGAG
GCATTTGAGGGTTATGACTCCATCGACAGCCCCAAGGCCATCACATCTCTGAAGTACATGTTGCTGTGCAAAATCATGCTCAACACCCCA
GAAGATGTCCAGGCTTTGGTGAGCGGGAAGCTTGCACTTCGGTATGCAGGGAGGCAGACAGAAGCATTAAAATGCGTGGCTCAGGCTAGC
AAGAACAGATCACTGGCAGATTTTGAAAAGGCTCTGACAGATTACCGGGCAGAGCTCCGGGATGACCCAATCATCAGCACACACTTGGCC
AAGTTGTATGATAACTTACTAGAACAGAATCTGATCCGAGTCATTGAGCCTTTTTCCAGAGTACAGATTGAACACATATCTAGTCTCATC
AAACTCTCCAAGGCCGACGTGGAAAGGAAATTATCACAGATGATTCTTGACAAGAAATTTCATGGGATTTTGGACCAGGGGGAGGGTGTC
CTGATTATTTTCGATGAACCCCCAGTAGATAAAACTTACGAAGCTGCTCTGGAAACAATTCAGAACATGAGCAAAGTAGTGGATTCCCTC
TACAACAAAGCCAAGAAACTGACATAGAGTTGGATCTGTAGCGGTCCTTTGGAGAGTGTGTGTGGCGGGAGAGTGAAACCTTGGGGGAAA
ATGCTAGGAGATTCTTTTTTCTTTTTGTTCTACTTTTCGCTCGGAAAGTTTTTAAATCCTCATTTGGTGCATCTGTATTCCAGCCAATAG
GTGTGCCAGTTTTCATGTAATCTTTACTGGCCCAACTTGGGAGTGGGGAAATTGCTTAAAAAAAAAGAAAAAGAAAAAAAAAAAGATTAT
TCTAAATAAAAGGAAAAAGGCTTACACTACCTAAAGCTGTGCTCTCTGCCTCCTGGGAGAGGGCCGCAAAGCCAGGCACCCCGCCAACCA
CTGGGGGTCCTAATCCACCTGCTGGGCATCACCTCTCCTCCTCCTCAGAATTGGGTGTTTGCTGACCATCAAAAGCAATGACTTTTTATT
CTGTTTGTACTGAACCAAAACAAACAACTGTGTATAGACTGCTGTTTTCTTTTTTATTTGAAATGAGGCATTTTGGTGTTCTTTCCCCTA
CCATACGGCCTGTCTGCCCTTCCCTCCCCACATTGGCTCCAGCAGAGTAGCCGAAGGTCCTGCCGCCGCCGCCACCACCACCACCACTGC
AGCAACAACAGCAGCAGCAGCAGCAGCGCCTGCATAGCTCCACTCTGACCTGTGAAGGAATGGGGATGAGGCCAGGAGCTAGTGTCTACC
ACGGCCACACAGGGAGCAGTGTGGGCCCTTAGCCCCCAAGGGGCCTGCTATGCATGTGGCTTTTTTTTTTTTTTTAAACACAGTAAACTA
GATTAGTCGTCAGTGTTTTAATTGCCCCTCTTCTCCTCTCCTGCATTCCTCTCCTCTCTTCTTTCCTCTCTGTCCCTTCTCTTTCCCCTC
TCAACCAGGAGACCATCATGTCTCTCTGCCTTCCTCCTCTCCCCTCCAGGGGAGTCAGGCTGTCTGTGAAAGCCATGAGCTTCTCTCCCT
CTCCCACTCCTCCTCTCCTACTTTCAGATGGATTTATTCCTTTTTTAAACAATGAACATCGGAAATGAGACTGTGGGGTGTGGTTTCTCT
CTCTCTTTTTTTTTTAATTTTCTTTGTTGGGTTTTTGAGCAACCTCATGTCCCCTTCCCAGGGAGCTTTTTAATTTACCTCTTAGAACTC
AAGTGGATGGGAAGTAGAGCACTATGTGTCAGTATGCTTTGTTTTCTGACACGATTACACAGCGAGGCTTTAATGCCATTTGGGTAGGTG
AGCTTCTGCACTTCTGTTGTGCTGAACTGTATTTTCTTCTCTCATCTCCTCTTTGTCTTTTTCTCTTTTCCTCTCCTTCCTGCCTTCTTC
TGCTGGCCTCCTTTTCTCTTTCTTTACCTTCCTTGGATTATCCTTCCAGGTTTTCATAATAAATTTATATTTTGTAAAAGGATTTTGTTG
TACCAGGTTTTGCATCCTCACTGAATCTGACTGGCTTTTATTTTCCTCTCCAAAATCAGGTTTTTGTTCTCAACATCTTTCCCCATCATG
TCTAGTCACTGTTTTGGTTTTGGCACCATCAGTATCAAATGTACAAACGGTTCTTGCTAACCAACACCAGGTATATCTGATGTTCAGATG
AGTTCCAATAAAAATAATTTTTTTTTTTTTCAAAAGGTGTCTTTTTCTTGAGTGCTGGAGGGCTTCCAAGCAAGTCCAGACAGCTCTGTG
TGGCCCCACACTAGTCTAGCTCTCATCTGGCCAAAGCTGTTATCTCATTTGTGTAATGGGAGTCCTTAAGGTAAATTTGGGGTCCAAACT
TGGAGGGCTTTGGGGGCAAGAAAGTTGGTGTGTGAGTTCTGAGGTTGGAAATGAGTTCAGGTGTCTTCTTCCAGGGCAGCATGGTCCAGT
GAGCACATGTAAGTTTGGGCAGTAGATCCTCTGAGCCTACTTTCTCTTCTACTCAGTGAGGATGCTGCTTCCTTGGCAGGTGATTGTGAT
GTGAAGCTTAGTAAGTCATAGACGTGCAGGTGTCTGGAGAGTCCTGACATGCAGTTGTGGTTTCGTTTCCTTTTGGAATCTTCAAAGGCA
GCGATTTTCATATTGCCTCACACCCTGGCGGGGGCGGGGGGCTCTGGGACCACTGGGGGACCTGCTAAATCCTCTTCAGTCTGAGCAGTT
CAGCCATTGTCAGTTTTAGTATTGTGTCTCTGTATTTCACTTGCAGAAAGAGCTTTGCTTCTATAAAGGACTTTAAAAAGTACTCCAAAG
AGATCTAGTTTTGGAGTAGAGGGGAGATGTTTTCTCAAACTTAGGGCAGTCCTGAGATGCTCAGGCAGTAGCCCTTTTCTCAGTTCCCTT
TGCGGGTCTTGGTCAGATGATGCCCTCTAGACCCGTGCTGTCCAATATGTAGCCGCTAGCCATGTGCAGCTGTCAGGCCCTTGCAACGTG
GCTGGTTCGAGCTGTGATACACTGCAAGTGTAAACACAAACCAGACTTCGAAGGCTTAGTATGATAACAAAAGAAAAGGAGTGTAAAATA

>82063_82063_3_SKAP1-PSMD11_SKAP1_chr17_46423267_ENST00000584924_PSMD11_chr17_30773963_ENST00000261712_length(amino acids)=485AA_BP=93
MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDY
QDEVKRDIQENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWA
KSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKLQ
ATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNR
SLADFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLII

--------------------------------------------------------------
>82063_82063_4_SKAP1-PSMD11_SKAP1_chr17_46423267_ENST00000584924_PSMD11_chr17_30773963_ENST00000457654_length(transcript)=2397nt_BP=379nt
GAGGTACAGGTGCCTCGCGGTGCAGCCGGGTCGCCTTCCAGCCCGTCCGCCTCCCGACCAGGGCCCGCGCCCCGTCCCGCCTCTCTCCCG
CCCAGCCAAATGCAGGCCGCCGCCCTCCCTGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAAT
GAGAACCTCAGCGCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAG
CCCCAAGGGGGAGACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTG
TCAGATTATCAGGATGAGGTGAAGCGTGACATTCAGGAAAACGATGAAGAGGCAGTGCAAGTCAAAGAGCAGAGCATCCTGGAACTGGGA
TCTCTCCTGGCAAAGACTGGACAAGCTGCAGAGCTTGGAGGACTCCTGAAGTATGTACGACCCTTCTTGAATTCCATCAGCAAGGCTAAA
GCAGCTCGCCTGGTCCGATCTCTTCTTGATCTGTTTCTTGATATGGAAGCAGCTACAGGGCAGGAGGTCGAGCTGTGTTTAGAGTGCATC
GAATGGGCCAAGTCAGAGAAAAGAACTTTCTTACGCCAAGCTTTGGAGGCAAGACTGGTGTCTTTGTACTTTGATACCAAGAGGTACCAG
GAAGCATTGCATTTGGGTTCTCAGCTGCTGCGGGAGTTGAAAAAGATGGACGACAAAGCTCTTTTGGTGGAAGTACAGCTTTTAGAAAGC
AAAACATACCATGCCCTGAGCAACCTGCCGAAAGCCCGAGCTGCCTTAACTTCTGCTCGAACCACAGCAAATGCCATCTACTGCCCCCCT
AAATTGCAGGCCACCTTGGACATGCAGTCGGGTATTATCCATGCAGCAGAAGAGAAGGACTGGAAAACTGCGTACTCATACTTCTATGAG
GCATTTGAGGGTTATGACTCCATCGACAGCCCCAAGGCCATCACATCTCTGAAGTACATGTTGCTGTGCAAAATCATGCTCAACACCCCA
GAAGATGTCCAGGCTTTGGTGAGCGGGAAGCTTGCACTTCGGTATGCAGGGAGGCAGACAGAAGCATTAAAATGCGTGGCTCAGGCTAGC
AAGAACAGATCACTGGCAGATTTTGAAAAGGCTCTGACAGATTACCGGGCAGAGCTCCGGGATGACCCAATCATCAGCACACACTTGGCC
AAGTTGTATGATAACTTACTAGAACAGAATCTGATCCGAGTCATTGAGCCTTTTTCCAGAGTACAGATTGAACACATATCTAGTCTCATC
AAACTCTCCAAGGCCGACGTGGAAAGGAAATTATCACAGATGATTCTTGACAAGAAATTTCATGGGATTTTGGACCAGGGGGAGGGTGTC
CTGATTATTTTCGATGAACCCCCAGTAGATAAAACTTACGAAGCTGCTCTGGAAACAATTCAGAACATGAGCAAAGTAGTGGATTCCCTC
TACAACAAAGCCAAGAAACTGACATAGGTGAGTGCTGGCTTCAGGACCCCAGGGCTGGGCAGCTCTGTCTTCTGCGTGTCGAGACTGAAA
ACCTCCTCCTGGTGTCCTCATGGCTTCCTGATTGACACTGCTCTGTCTTCTCTTGCAGAGTTGGATCTGTAGCGGTCCTTTGGAGAGTGT
GTGTGGCGGGAGAGTGAAACCTTGGGGGAAAATGCTAGGAGATTCTTTTTTCTTTTTGTTCTACTTTTCGCTCGGAAAGTTTTTAAATCC
TCATTTGGTGCATCTGTATTCCAGCCAATAGGTGTGCCAGTTTTCATGTAATCTTTACTGGCCCAACTTGGGAGTGGGGAAATTGCTTAA
AAAAAAAGAAAAAGAAAAAAAAAAAGATTATTCTAAATAAAAGGAAAAAGGCTTACACTACCTAAAGCTGTGCTCTCTGCCTCCTGGGAG
AGGGCCGCAAAGCCAGGCACCCCGCCAACCACTGGGGGTCCTAATCCACCTGCTGGGCATCACCTCTCCTCCTCCTCAGAATTGGGTGTT
TGCTGACCATCAAAAGCAATGACTTTTTATTCTGTTTGTACTGAACCAAAACAAACAACTGTGTATAGACTGCTGTTTTCTTTTTTATTT
GAAATGAGGCATTTTGGTGTTCTTTCCCCTACCATACGGCCTGTCTGCCCTTCCCTCCCCACATTGGCTCCAGCAGAGTAGCCGAAGGTC
CTGCCGCCGCCGCCACCACCACCACCACTGCAGCAACAACAGCAGCAGCAGCAGCAGCGCCTGCATAGCTCCACTCTGACCTGTGAAGGA

>82063_82063_4_SKAP1-PSMD11_SKAP1_chr17_46423267_ENST00000584924_PSMD11_chr17_30773963_ENST00000457654_length(amino acids)=485AA_BP=93
MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDY
QDEVKRDIQENDEEAVQVKEQSILELGSLLAKTGQAAELGGLLKYVRPFLNSISKAKAARLVRSLLDLFLDMEAATGQEVELCLECIEWA
KSEKRTFLRQALEARLVSLYFDTKRYQEALHLGSQLLRELKKMDDKALLVEVQLLESKTYHALSNLPKARAALTSARTTANAIYCPPKLQ
ATLDMQSGIIHAAEEKDWKTAYSYFYEAFEGYDSIDSPKAITSLKYMLLCKIMLNTPEDVQALVSGKLALRYAGRQTEALKCVAQASKNR
SLADFEKALTDYRAELRDDPIISTHLAKLYDNLLEQNLIRVIEPFSRVQIEHISSLIKLSKADVERKLSQMILDKKFHGILDQGEGVLII

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SKAP1-PSMD11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSKAP1chr17:46423267chr17:30773963ENST00000336915-413290_29593.33333333333333448.0FYB1
HgeneSKAP1chr17:46423267chr17:30773963ENST00000584924-412290_29593.33333333333333360.0FYB1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SKAP1-PSMD11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SKAP1-PSMD11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource