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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SKAP1-WDR1 (FusionGDB2 ID:82069)

Fusion Gene Summary for SKAP1-WDR1

check button Fusion gene summary
Fusion gene informationFusion gene name: SKAP1-WDR1
Fusion gene ID: 82069
HgeneTgene
Gene symbol

SKAP1

WDR1

Gene ID

8631

9948

Gene namesrc kinase associated phosphoprotein 1WD repeat domain 1
SynonymsHEL-S-81p|SCAP1|SKAP55AIP1|HEL-S-52|NORI-1
Cytomap

17q21.32

4p16.1

Type of geneprotein-codingprotein-coding
Descriptionsrc kinase-associated phosphoprotein 1SKAP-55epididymis secretory sperm binding protein Li 81ppp55src family-associated phosphoprotein 1src kinase-associated phosphoprotein of 55 kDaWD repeat-containing protein 1actin-interacting protein 1epididymis secretory protein Li 52
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000336915, ENST00000584924, 
ENST00000502702, ENST00000515743, 
ENST00000382451, ENST00000382452, 
ENST00000499869, 
Fusion gene scores* DoF score26 X 10 X 10=260010 X 12 X 6=720
# samples 3514
** MAII scorelog2(35/2600*10)=-2.89308479608349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/720*10)=-2.36257007938471
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SKAP1 [Title/Abstract] AND WDR1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSKAP1(46423266)-WDR1(10117858), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSKAP1

GO:0002821

positive regulation of adaptive immune response

12652296

HgeneSKAP1

GO:0033625

positive regulation of integrin activation

12652296

HgeneSKAP1

GO:0034116

positive regulation of heterotypic cell-cell adhesion

12652296

HgeneSKAP1

GO:0045944

positive regulation of transcription by RNA polymerase II

11909961

HgeneSKAP1

GO:1903039

positive regulation of leukocyte cell-cell adhesion

12652296

TgeneWDR1

GO:0030834

regulation of actin filament depolymerization

15629458

TgeneWDR1

GO:0043297

apical junction assembly

25792565

TgeneWDR1

GO:0045199

maintenance of epithelial cell apical/basal polarity

25792565


check buttonFusion gene breakpoints across SKAP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across WDR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-09-2056SKAP1chr17

46423266

-WDR1chr4

10117858

-


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Fusion Gene ORF analysis for SKAP1-WDR1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000336915ENST00000502702SKAP1chr17

46423266

-WDR1chr4

10117858

-
5CDS-intronENST00000336915ENST00000515743SKAP1chr17

46423266

-WDR1chr4

10117858

-
5CDS-intronENST00000584924ENST00000502702SKAP1chr17

46423266

-WDR1chr4

10117858

-
5CDS-intronENST00000584924ENST00000515743SKAP1chr17

46423266

-WDR1chr4

10117858

-
In-frameENST00000336915ENST00000382451SKAP1chr17

46423266

-WDR1chr4

10117858

-
In-frameENST00000336915ENST00000382452SKAP1chr17

46423266

-WDR1chr4

10117858

-
In-frameENST00000336915ENST00000499869SKAP1chr17

46423266

-WDR1chr4

10117858

-
In-frameENST00000584924ENST00000382451SKAP1chr17

46423266

-WDR1chr4

10117858

-
In-frameENST00000584924ENST00000382452SKAP1chr17

46423266

-WDR1chr4

10117858

-
In-frameENST00000584924ENST00000499869SKAP1chr17

46423266

-WDR1chr4

10117858

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336915SKAP1chr1746423266-ENST00000499869WDR1chr410117858-3194350702154694
ENST00000336915SKAP1chr1746423266-ENST00000382451WDR1chr410117858-2773350701734554
ENST00000336915SKAP1chr1746423266-ENST00000382452WDR1chr410117858-3193350702154694
ENST00000584924SKAP1chr1746423266-ENST00000499869WDR1chr410117858-3223379992183694
ENST00000584924SKAP1chr1746423266-ENST00000382451WDR1chr410117858-2802379991763554
ENST00000584924SKAP1chr1746423266-ENST00000382452WDR1chr410117858-3222379992183694

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336915ENST00000499869SKAP1chr1746423266-WDR1chr410117858-0.0010238210.99897623
ENST00000336915ENST00000382451SKAP1chr1746423266-WDR1chr410117858-0.0012642340.9987357
ENST00000336915ENST00000382452SKAP1chr1746423266-WDR1chr410117858-0.0010135750.9989864
ENST00000584924ENST00000499869SKAP1chr1746423266-WDR1chr410117858-0.0009931480.9990069
ENST00000584924ENST00000382451SKAP1chr1746423266-WDR1chr410117858-0.0012403210.99875975
ENST00000584924ENST00000382452SKAP1chr1746423266-WDR1chr410117858-0.0009829440.999017

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Fusion Genomic Features for SKAP1-WDR1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SKAP1-WDR1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:46423266/chr4:10117858)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneWDR1chr17:46423266chr4:10117858ENST00000382451012138_1765467.0RepeatNote=WD 4
TgeneWDR1chr17:46423266chr4:10117858ENST00000382451012180_2185467.0RepeatNote=WD 5
TgeneWDR1chr17:46423266chr4:10117858ENST00000382451012224_2635467.0RepeatNote=WD 6
TgeneWDR1chr17:46423266chr4:10117858ENST00000382451012270_3065467.0RepeatNote=WD 7
TgeneWDR1chr17:46423266chr4:10117858ENST00000382451012311_3515467.0RepeatNote=WD 8
TgeneWDR1chr17:46423266chr4:10117858ENST00000382451012358_4085467.0RepeatNote=WD 9
TgeneWDR1chr17:46423266chr4:10117858ENST00000382451012432_4745467.0RepeatNote=WD 10
TgeneWDR1chr17:46423266chr4:10117858ENST00000382451012480_5185467.0RepeatNote=WD 11
TgeneWDR1chr17:46423266chr4:10117858ENST0000038245101248_875467.0RepeatNote=WD 2
TgeneWDR1chr17:46423266chr4:10117858ENST000003824510124_455467.0RepeatNote=WD 1
TgeneWDR1chr17:46423266chr4:10117858ENST00000382451012523_5615467.0RepeatNote=WD 12
TgeneWDR1chr17:46423266chr4:10117858ENST00000382451012566_6045467.0RepeatNote=WD 13
TgeneWDR1chr17:46423266chr4:10117858ENST0000038245101293_1355467.0RepeatNote=WD 3
TgeneWDR1chr17:46423266chr4:10117858ENST00000382452015138_1765607.0RepeatNote=WD 4
TgeneWDR1chr17:46423266chr4:10117858ENST00000382452015180_2185607.0RepeatNote=WD 5
TgeneWDR1chr17:46423266chr4:10117858ENST00000382452015224_2635607.0RepeatNote=WD 6
TgeneWDR1chr17:46423266chr4:10117858ENST00000382452015270_3065607.0RepeatNote=WD 7
TgeneWDR1chr17:46423266chr4:10117858ENST00000382452015311_3515607.0RepeatNote=WD 8
TgeneWDR1chr17:46423266chr4:10117858ENST00000382452015358_4085607.0RepeatNote=WD 9
TgeneWDR1chr17:46423266chr4:10117858ENST00000382452015432_4745607.0RepeatNote=WD 10
TgeneWDR1chr17:46423266chr4:10117858ENST00000382452015480_5185607.0RepeatNote=WD 11
TgeneWDR1chr17:46423266chr4:10117858ENST0000038245201548_875607.0RepeatNote=WD 2
TgeneWDR1chr17:46423266chr4:10117858ENST000003824520154_455607.0RepeatNote=WD 1
TgeneWDR1chr17:46423266chr4:10117858ENST00000382452015523_5615607.0RepeatNote=WD 12
TgeneWDR1chr17:46423266chr4:10117858ENST00000382452015566_6045607.0RepeatNote=WD 13
TgeneWDR1chr17:46423266chr4:10117858ENST0000038245201593_1355607.0RepeatNote=WD 3
TgeneWDR1chr17:46423266chr4:10117858ENST00000499869015138_1765607.0RepeatNote=WD 4
TgeneWDR1chr17:46423266chr4:10117858ENST00000499869015180_2185607.0RepeatNote=WD 5
TgeneWDR1chr17:46423266chr4:10117858ENST00000499869015224_2635607.0RepeatNote=WD 6
TgeneWDR1chr17:46423266chr4:10117858ENST00000499869015270_3065607.0RepeatNote=WD 7
TgeneWDR1chr17:46423266chr4:10117858ENST00000499869015311_3515607.0RepeatNote=WD 8
TgeneWDR1chr17:46423266chr4:10117858ENST00000499869015358_4085607.0RepeatNote=WD 9
TgeneWDR1chr17:46423266chr4:10117858ENST00000499869015432_4745607.0RepeatNote=WD 10
TgeneWDR1chr17:46423266chr4:10117858ENST00000499869015480_5185607.0RepeatNote=WD 11
TgeneWDR1chr17:46423266chr4:10117858ENST0000049986901548_875607.0RepeatNote=WD 2
TgeneWDR1chr17:46423266chr4:10117858ENST000004998690154_455607.0RepeatNote=WD 1
TgeneWDR1chr17:46423266chr4:10117858ENST00000499869015523_5615607.0RepeatNote=WD 12
TgeneWDR1chr17:46423266chr4:10117858ENST00000499869015566_6045607.0RepeatNote=WD 13
TgeneWDR1chr17:46423266chr4:10117858ENST0000049986901593_1355607.0RepeatNote=WD 3
TgeneWDR1chr17:46423266chr4:10117858ENST00000502702012138_1765467.0RepeatNote=WD 4
TgeneWDR1chr17:46423266chr4:10117858ENST00000502702012180_2185467.0RepeatNote=WD 5
TgeneWDR1chr17:46423266chr4:10117858ENST00000502702012224_2635467.0RepeatNote=WD 6
TgeneWDR1chr17:46423266chr4:10117858ENST00000502702012270_3065467.0RepeatNote=WD 7
TgeneWDR1chr17:46423266chr4:10117858ENST00000502702012311_3515467.0RepeatNote=WD 8
TgeneWDR1chr17:46423266chr4:10117858ENST00000502702012358_4085467.0RepeatNote=WD 9
TgeneWDR1chr17:46423266chr4:10117858ENST00000502702012432_4745467.0RepeatNote=WD 10
TgeneWDR1chr17:46423266chr4:10117858ENST00000502702012480_5185467.0RepeatNote=WD 11
TgeneWDR1chr17:46423266chr4:10117858ENST0000050270201248_875467.0RepeatNote=WD 2
TgeneWDR1chr17:46423266chr4:10117858ENST000005027020124_455467.0RepeatNote=WD 1
TgeneWDR1chr17:46423266chr4:10117858ENST00000502702012523_5615467.0RepeatNote=WD 12
TgeneWDR1chr17:46423266chr4:10117858ENST00000502702012566_6045467.0RepeatNote=WD 13
TgeneWDR1chr17:46423266chr4:10117858ENST0000050270201293_1355467.0RepeatNote=WD 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSKAP1chr17:46423266chr4:10117858ENST00000336915-413220_23093448.0Compositional biasNote=Poly-Glu
HgeneSKAP1chr17:46423266chr4:10117858ENST00000584924-412220_23093360.0Compositional biasNote=Poly-Glu
HgeneSKAP1chr17:46423266chr4:10117858ENST00000336915-413107_21093448.0DomainPH
HgeneSKAP1chr17:46423266chr4:10117858ENST00000336915-413294_35593448.0DomainSH3
HgeneSKAP1chr17:46423266chr4:10117858ENST00000584924-412107_21093360.0DomainPH
HgeneSKAP1chr17:46423266chr4:10117858ENST00000584924-412294_35593360.0DomainSH3


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Fusion Gene Sequence for SKAP1-WDR1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>82069_82069_1_SKAP1-WDR1_SKAP1_chr17_46423266_ENST00000336915_WDR1_chr4_10117858_ENST00000382451_length(transcript)=2773nt_BP=350nt
GTCGCCTTCCAGCCCGTCCGCCTCCCGACCAGGGCCCGCGCCCCGTCCCGCCTCTCTCCCGCCCAGCCAAATGCAGGCCGCCGCCCTCCC
TGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTCAGCGCTGTTGCAAGGGATCA
CAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGGGGAGACATTGGACAGGACAG
CTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTATCAGGATGAGGAGAAGGTGTT
CGCCAGCCTCCCGCAGGTGGAGAGGGGCGTCTCCAAGATCATCGGCGGCGACCCTAAGGGCAACAATTTTCTGTACACCAATGGAAAGTG
CGTCATCCTAAGGAACATCGACGACCACAGCCGCTTTGTCAACTGTGTGCGATTCTCTCCTGATGGGAACAGATTTGCCACAGCCAGTGC
TGACGGCCAGATATACATCTATGACGGGAAGACTGGGGAGAAGGTGTGCGCGCTGGGCGGAAGCAAGGCCCACGACGGTGGGATTTACGC
AATTAGTTGGAGTCCCGACAGCACCCATTTGCTTTCTGCTTCTGGGGACAAAACTTCCAAGATTTGGGACGTCAGCGTGAACTCCGTGGT
CAGCACATTTCCCATGGGCTCCACGGTTCTGGACCAGCAGCTGGGCTGCCTATGGCAGAAGGACCACCTGCTCAGTGTCTCCCTGTCCGG
GTACATCAACTATCTGGACAGAAACAACCCCAGCAAGCCCCTGCACGTCATCAAGGGTCACAGTAAATCGATCCAGTGTCTGACGGTGCA
TAAAAACGGCGGCAAGTCCTACATTTACTCTGGGAGCCACGACGGACACATTAATTACTGGGATTCAGAGACGGGGGAGAACGACTCCTT
CGCTGGGAAAGGCCACACGAACCAGGTGTCCAGGATGACCGTGGATGAGTCGGGGCAGCTCATCAGCTGCAGCATGGACGACACCGTGCG
GTACACCAGCCTCATGCTGCGGGACTACAGCGGACAAGGAGTTGTGAAACTGGACGTTCAGCCAAAGTGCGTAGCCGTCGGCCCCGGGGG
ATACGCCGTGGTCGTGTGCATTGGACAGATTGTCCTGCTGAAGGATCAGAGGAAGTGCTTCAGCATCGACAACCCCGGCTACGAGCCCGA
AGTTGTGGCAGTGCACCCCGGCGGGGACACGGTGGCAATTGGGGGTGTGGACGGCAACGTCCGCCTGTATTCCATCCTGGGCACCACGCT
GAAGGATGAGGGCAAGCTCCTAGAGGCCAAGGGCCCCGTGACCGACGTGGCCTACTCCCACGACGGCGCCTTCCTCGCGGTGTGCGACGC
CAGCAAGGTGGTCACAGTGTTCAGCGTTGCTGACGGCTACTCGGAGAACAATGTTTTTTATGGACACCATGCAAAAATCGTCTGCCTGGC
CTGGTCCCCAGACAATGAACACTTTGCCTCCGGTGGCATGGACATGATGGTGTATGTTTGGACCCTGAGTGACCCGGAAACCAGAGTCAA
GATCCAAGATGCACACCGGCTGCACCATGTCAGCAGCCTGGCCTGGCTGGACGAGCACACGCTGGTCACGACCTCCCATGATGCCTCTGT
CAAGGAGTGGACAATCACCTACTGAGGAGCCCCACCCCCGCCTCTGGATGGACCGAATCAGGGACTAGAGTTTAACTGCAGCGGAACATG
TCATTTCTCTATTTCTGTGACGCGCCCCCATGCCCCCACCCCACCACAAGAGGCAGGAGGGCCCAGTCATGACCCTCGTCTCTGCAGGGT
GTCTGTACACGTTCTTCTGAAAGCTTTAGACAGTAACAGTTTGCACATGAAAAATAAAGCGAGCACCTAAACAATGTGTGGAGCATAACT
AAAACCCACAGCCCAACCAAACCTTGAGAATGCGAAACATTCCAGAGGCAGTAGCCTCCAAAGCACACAGAGCCCCTGGCCCCGCCGCGG
CTCTCACTATCTGTCAGGGGAGGTTGTACAGGTGAATGAGCCGGGGGGCTCATGTTCCTGCCTGCAGAACATTTCTGTACTAGTGAGAAG
AGGGAATATGCATTGCAGTTCAGCAAAGCCGGAATTCTGTGTTGAACAGATGTCTGTCTCCCTAGTGTGTGACTCACACCTTGTGGCTGC
CTTCAGAGCGCCACCTCCAGATCAGATGGGGACACACAACCCCTGGATATGTTTCATTGTCAGATTTTGTGCTTGATTTTAAGAATGGAA
TTGTGGGTATCTTTCCTTTTTTTTTAATGTATCTTAACTGTTGCCTGTCAGTGTTTACAAACTAGTGCGTTGACGGCACCGTGTCCAAGT
TTTTAGAACCCTTGTTAGCCAGACCGAGGTGTCCTGGTCACCGTTTCACCATCATGCTTTGATGTTCCCCTGTCTTTCCCTCTTCTGCTC
TCAAGAGCAAAGGTTAATTTAAGGACAAAGATGAAGTCACTGTAAACTAATCTGTCATTGTTTTTACCTTCCTTTTCTTTTTCAGTGCAG
AAATTAAAAGTAAGTATAAAGCACCGTGATTGGGAGTGTTTTTGCGTGTGTCGGAATCACTGGTAAATGTTGGCTGAGAACAATCCCTCC

>82069_82069_1_SKAP1-WDR1_SKAP1_chr17_46423266_ENST00000336915_WDR1_chr4_10117858_ENST00000382451_length(amino acids)=554AA_BP=93
MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDY
QDEEKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKA
HDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKS
IQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKC
VAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGA
FLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVT

--------------------------------------------------------------
>82069_82069_2_SKAP1-WDR1_SKAP1_chr17_46423266_ENST00000336915_WDR1_chr4_10117858_ENST00000382452_length(transcript)=3193nt_BP=350nt
GTCGCCTTCCAGCCCGTCCGCCTCCCGACCAGGGCCCGCGCCCCGTCCCGCCTCTCTCCCGCCCAGCCAAATGCAGGCCGCCGCCCTCCC
TGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTCAGCGCTGTTGCAAGGGATCA
CAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGGGGAGACATTGGACAGGACAG
CTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTATCAGGATGAGGAGAAGGTGTT
CGCCAGCCTCCCGCAGGTGGAGAGGGGCGTCTCCAAGATCATCGGCGGCGACCCTAAGGGCAACAATTTTCTGTACACCAATGGAAAGTG
CGTCATCCTAAGGAACATCGACAACCCAGCCCTTGCTGACATCTACACAGAGCACGCCCATCAGGTGGTGGTGGCCAAGTATGCGCCCAG
CGGATTCTACATTGCCTCCGGAGATGTGTCTGGGAAGCTGAGGATCTGGGATACCACGCAGAAGGAGCACCTGTTGAAGTATGAGTACCA
GCCTTTCGCTGGGAAGATCAAAGACATTGCTTGGACTGAAGACAGTAAGAGGATCGCCGTGGTCGGGGAAGGAAGGGAGAAGTTTGGAGC
AGTCTTCCTCTGGGATAGTGGCTCTTCTGTGGGCGAGATTACAGGACACAACAAAGTCATCAACAGCGTGGACATCAAGCAGAGCCGGCC
ATACCGGCTGGCCACGGGAAGCGATGATAACTGCGCGGCATTCTTTGAGGGACCCCCATTCAAGTTCAAGTTCACAATTGGCGACCACAG
CCGCTTTGTCAACTGTGTGCGATTCTCTCCTGATGGGAACAGATTTGCCACAGCCAGTGCTGACGGCCAGATATACATCTATGACGGGAA
GACTGGGGAGAAGGTGTGCGCGCTGGGCGGAAGCAAGGCCCACGACGGTGGGATTTACGCAATTAGTTGGAGTCCCGACAGCACCCATTT
GCTTTCTGCTTCTGGGGACAAAACTTCCAAGATTTGGGACGTCAGCGTGAACTCCGTGGTCAGCACATTTCCCATGGGCTCCACGGTTCT
GGACCAGCAGCTGGGCTGCCTATGGCAGAAGGACCACCTGCTCAGTGTCTCCCTGTCCGGGTACATCAACTATCTGGACAGAAACAACCC
CAGCAAGCCCCTGCACGTCATCAAGGGTCACAGTAAATCGATCCAGTGTCTGACGGTGCATAAAAACGGCGGCAAGTCCTACATTTACTC
TGGGAGCCACGACGGACACATTAATTACTGGGATTCAGAGACGGGGGAGAACGACTCCTTCGCTGGGAAAGGCCACACGAACCAGGTGTC
CAGGATGACCGTGGATGAGTCGGGGCAGCTCATCAGCTGCAGCATGGACGACACCGTGCGGTACACCAGCCTCATGCTGCGGGACTACAG
CGGACAAGGAGTTGTGAAACTGGACGTTCAGCCAAAGTGCGTAGCCGTCGGCCCCGGGGGATACGCCGTGGTCGTGTGCATTGGACAGAT
TGTCCTGCTGAAGGATCAGAGGAAGTGCTTCAGCATCGACAACCCCGGCTACGAGCCCGAAGTTGTGGCAGTGCACCCCGGCGGGGACAC
GGTGGCAATTGGGGGTGTGGACGGCAACGTCCGCCTGTATTCCATCCTGGGCACCACGCTGAAGGATGAGGGCAAGCTCCTAGAGGCCAA
GGGCCCCGTGACCGACGTGGCCTACTCCCACGACGGCGCCTTCCTCGCGGTGTGCGACGCCAGCAAGGTGGTCACAGTGTTCAGCGTTGC
TGACGGCTACTCGGAGAACAATGTTTTTTATGGACACCATGCAAAAATCGTCTGCCTGGCCTGGTCCCCAGACAATGAACACTTTGCCTC
CGGTGGCATGGACATGATGGTGTATGTTTGGACCCTGAGTGACCCGGAAACCAGAGTCAAGATCCAAGATGCACACCGGCTGCACCATGT
CAGCAGCCTGGCCTGGCTGGACGAGCACACGCTGGTCACGACCTCCCATGATGCCTCTGTCAAGGAGTGGACAATCACCTACTGAGGAGC
CCCACCCCCGCCTCTGGATGGACCGAATCAGGGACTAGAGTTTAACTGCAGCGGAACATGTCATTTCTCTATTTCTGTGACGCGCCCCCA
TGCCCCCACCCCACCACAAGAGGCAGGAGGGCCCAGTCATGACCCTCGTCTCTGCAGGGTGTCTGTACACGTTCTTCTGAAAGCTTTAGA
CAGTAACAGTTTGCACATGAAAAATAAAGCGAGCACCTAAACAATGTGTGGAGCATAACTAAAACCCACAGCCCAACCAAACCTTGAGAA
TGCGAAACATTCCAGAGGCAGTAGCCTCCAAAGCACACAGAGCCCCTGGCCCCGCCGCGGCTCTCACTATCTGTCAGGGGAGGTTGTACA
GGTGAATGAGCCGGGGGGCTCATGTTCCTGCCTGCAGAACATTTCTGTACTAGTGAGAAGAGGGAATATGCATTGCAGTTCAGCAAAGCC
GGAATTCTGTGTTGAACAGATGTCTGTCTCCCTAGTGTGTGACTCACACCTTGTGGCTGCCTTCAGAGCGCCACCTCCAGATCAGATGGG
GACACACAACCCCTGGATATGTTTCATTGTCAGATTTTGTGCTTGATTTTAAGAATGGAATTGTGGGTATCTTTCCTTTTTTTTTAATGT
ATCTTAACTGTTGCCTGTCAGTGTTTACAAACTAGTGCGTTGACGGCACCGTGTCCAAGTTTTTAGAACCCTTGTTAGCCAGACCGAGGT
GTCCTGGTCACCGTTTCACCATCATGCTTTGATGTTCCCCTGTCTTTCCCTCTTCTGCTCTCAAGAGCAAAGGTTAATTTAAGGACAAAG
ATGAAGTCACTGTAAACTAATCTGTCATTGTTTTTACCTTCCTTTTCTTTTTCAGTGCAGAAATTAAAAGTAAGTATAAAGCACCGTGAT
TGGGAGTGTTTTTGCGTGTGTCGGAATCACTGGTAAATGTTGGCTGAGAACAATCCCTCCCCTTGCACTTGTGAAAACACTTTGAGCGCT

>82069_82069_2_SKAP1-WDR1_SKAP1_chr17_46423266_ENST00000336915_WDR1_chr4_10117858_ENST00000382452_length(amino acids)=694AA_BP=93
MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDY
QDEEKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEH
LLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFK
FTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTF
PMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGK
GHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVA
VHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSP

--------------------------------------------------------------
>82069_82069_3_SKAP1-WDR1_SKAP1_chr17_46423266_ENST00000336915_WDR1_chr4_10117858_ENST00000499869_length(transcript)=3194nt_BP=350nt
GTCGCCTTCCAGCCCGTCCGCCTCCCGACCAGGGCCCGCGCCCCGTCCCGCCTCTCTCCCGCCCAGCCAAATGCAGGCCGCCGCCCTCCC
TGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAATGAGAACCTCAGCGCTGTTGCAAGGGATCA
CAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAGCCCCAAGGGGGAGACATTGGACAGGACAG
CTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTGTCAGATTATCAGGATGAGGAGAAGGTGTT
CGCCAGCCTCCCGCAGGTGGAGAGGGGCGTCTCCAAGATCATCGGCGGCGACCCTAAGGGCAACAATTTTCTGTACACCAATGGAAAGTG
CGTCATCCTAAGGAACATCGACAACCCAGCCCTTGCTGACATCTACACAGAGCACGCCCATCAGGTGGTGGTGGCCAAGTATGCGCCCAG
CGGATTCTACATTGCCTCCGGAGATGTGTCTGGGAAGCTGAGGATCTGGGATACCACGCAGAAGGAGCACCTGTTGAAGTATGAGTACCA
GCCTTTCGCTGGGAAGATCAAAGACATTGCTTGGACTGAAGACAGTAAGAGGATCGCCGTGGTCGGGGAAGGAAGGGAGAAGTTTGGAGC
AGTCTTCCTCTGGGATAGTGGCTCTTCTGTGGGCGAGATTACAGGACACAACAAAGTCATCAACAGCGTGGACATCAAGCAGAGCCGGCC
ATACCGGCTGGCCACGGGAAGCGATGATAACTGCGCGGCATTCTTTGAGGGACCCCCATTCAAGTTCAAGTTCACAATTGGCGACCACAG
CCGCTTTGTCAACTGTGTGCGATTCTCTCCTGATGGGAACAGATTTGCCACAGCCAGTGCTGACGGCCAGATATACATCTATGACGGGAA
GACTGGGGAGAAGGTGTGCGCGCTGGGCGGAAGCAAGGCCCACGACGGTGGGATTTACGCAATTAGTTGGAGTCCCGACAGCACCCATTT
GCTTTCTGCTTCTGGGGACAAAACTTCCAAGATTTGGGACGTCAGCGTGAACTCCGTGGTCAGCACATTTCCCATGGGCTCCACGGTTCT
GGACCAGCAGCTGGGCTGCCTATGGCAGAAGGACCACCTGCTCAGTGTCTCCCTGTCCGGGTACATCAACTATCTGGACAGAAACAACCC
CAGCAAGCCCCTGCACGTCATCAAGGGTCACAGTAAATCGATCCAGTGTCTGACGGTGCATAAAAACGGCGGCAAGTCCTACATTTACTC
TGGGAGCCACGACGGACACATTAATTACTGGGATTCAGAGACGGGGGAGAACGACTCCTTCGCTGGGAAAGGCCACACGAACCAGGTGTC
CAGGATGACCGTGGATGAGTCGGGGCAGCTCATCAGCTGCAGCATGGACGACACCGTGCGGTACACCAGCCTCATGCTGCGGGACTACAG
CGGACAAGGAGTTGTGAAACTGGACGTTCAGCCAAAGTGCGTAGCCGTCGGCCCCGGGGGATACGCCGTGGTCGTGTGCATTGGACAGAT
TGTCCTGCTGAAGGATCAGAGGAAGTGCTTCAGCATCGACAACCCCGGCTACGAGCCCGAAGTTGTGGCAGTGCACCCCGGCGGGGACAC
GGTGGCAATTGGGGGTGTGGACGGCAACGTCCGCCTGTATTCCATCCTGGGCACCACGCTGAAGGATGAGGGCAAGCTCCTAGAGGCCAA
GGGCCCCGTGACCGACGTGGCCTACTCCCACGACGGCGCCTTCCTCGCGGTGTGCGACGCCAGCAAGGTGGTCACAGTGTTCAGCGTTGC
TGACGGCTACTCGGAGAACAATGTTTTTTATGGACACCATGCAAAAATCGTCTGCCTGGCCTGGTCCCCAGACAATGAACACTTTGCCTC
CGGTGGCATGGACATGATGGTGTATGTTTGGACCCTGAGTGACCCGGAAACCAGAGTCAAGATCCAAGATGCACACCGGCTGCACCATGT
CAGCAGCCTGGCCTGGCTGGACGAGCACACGCTGGTCACGACCTCCCATGATGCCTCTGTCAAGGAGTGGACAATCACCTACTGAGGAGC
CCCACCCCCGCCTCTGGATGGACCGAATCAGGGACTAGAGTTTAACTGCAGCGGAACATGTCATTTCTCTATTTCTGTGACGCGCCCCCA
TGCCCCCACCCCACCACAAGAGGCAGGAGGGCCCAGTCATGACCCTCGTCTCTGCAGGGTGTCTGTACACGTTCTTCTGAAAGCTTTAGA
CAGTAACAGTTTGCACATGAAAAATAAAGCGAGCACCTAAACAATGTGTGGAGCATAACTAAAACCCACAGCCCAACCAAACCTTGAGAA
TGCGAAACATTCCAGAGGCAGTAGCCTCCAAAGCACACAGAGCCCCTGGCCCCGCCGCGGCTCTCACTATCTGTCAGGGGAGGTTGTACA
GGTGAATGAGCCGGGGGGCTCATGTTCCTGCCTGCAGAACATTTCTGTACTAGTGAGAAGAGGGAATATGCATTGCAGTTCAGCAAAGCC
GGAATTCTGTGTTGAACAGATGTCTGTCTCCCTAGTGTGTGACTCACACCTTGTGGCTGCCTTCAGAGCGCCACCTCCAGATCAGATGGG
GACACACAACCCCTGGATATGTTTCATTGTCAGATTTTGTGCTTGATTTTAAGAATGGAATTGTGGGTATCTTTCCTTTTTTTTTAATGT
ATCTTAACTGTTGCCTGTCAGTGTTTACAAACTAGTGCGTTGACGGCACCGTGTCCAAGTTTTTAGAACCCTTGTTAGCCAGACCGAGGT
GTCCTGGTCACCGTTTCACCATCATGCTTTGATGTTCCCCTGTCTTTCCCTCTTCTGCTCTCAAGAGCAAAGGTTAATTTAAGGACAAAG
ATGAAGTCACTGTAAACTAATCTGTCATTGTTTTTACCTTCCTTTTCTTTTTCAGTGCAGAAATTAAAAGTAAGTATAAAGCACCGTGAT
TGGGAGTGTTTTTGCGTGTGTCGGAATCACTGGTAAATGTTGGCTGAGAACAATCCCTCCCCTTGCACTTGTGAAAACACTTTGAGCGCT

>82069_82069_3_SKAP1-WDR1_SKAP1_chr17_46423266_ENST00000336915_WDR1_chr4_10117858_ENST00000499869_length(amino acids)=694AA_BP=93
MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDY
QDEEKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEH
LLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFK
FTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTF
PMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGK
GHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVA
VHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSP

--------------------------------------------------------------
>82069_82069_4_SKAP1-WDR1_SKAP1_chr17_46423266_ENST00000584924_WDR1_chr4_10117858_ENST00000382451_length(transcript)=2802nt_BP=379nt
GAGGTACAGGTGCCTCGCGGTGCAGCCGGGTCGCCTTCCAGCCCGTCCGCCTCCCGACCAGGGCCCGCGCCCCGTCCCGCCTCTCTCCCG
CCCAGCCAAATGCAGGCCGCCGCCCTCCCTGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAAT
GAGAACCTCAGCGCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAG
CCCCAAGGGGGAGACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTG
TCAGATTATCAGGATGAGGAGAAGGTGTTCGCCAGCCTCCCGCAGGTGGAGAGGGGCGTCTCCAAGATCATCGGCGGCGACCCTAAGGGC
AACAATTTTCTGTACACCAATGGAAAGTGCGTCATCCTAAGGAACATCGACGACCACAGCCGCTTTGTCAACTGTGTGCGATTCTCTCCT
GATGGGAACAGATTTGCCACAGCCAGTGCTGACGGCCAGATATACATCTATGACGGGAAGACTGGGGAGAAGGTGTGCGCGCTGGGCGGA
AGCAAGGCCCACGACGGTGGGATTTACGCAATTAGTTGGAGTCCCGACAGCACCCATTTGCTTTCTGCTTCTGGGGACAAAACTTCCAAG
ATTTGGGACGTCAGCGTGAACTCCGTGGTCAGCACATTTCCCATGGGCTCCACGGTTCTGGACCAGCAGCTGGGCTGCCTATGGCAGAAG
GACCACCTGCTCAGTGTCTCCCTGTCCGGGTACATCAACTATCTGGACAGAAACAACCCCAGCAAGCCCCTGCACGTCATCAAGGGTCAC
AGTAAATCGATCCAGTGTCTGACGGTGCATAAAAACGGCGGCAAGTCCTACATTTACTCTGGGAGCCACGACGGACACATTAATTACTGG
GATTCAGAGACGGGGGAGAACGACTCCTTCGCTGGGAAAGGCCACACGAACCAGGTGTCCAGGATGACCGTGGATGAGTCGGGGCAGCTC
ATCAGCTGCAGCATGGACGACACCGTGCGGTACACCAGCCTCATGCTGCGGGACTACAGCGGACAAGGAGTTGTGAAACTGGACGTTCAG
CCAAAGTGCGTAGCCGTCGGCCCCGGGGGATACGCCGTGGTCGTGTGCATTGGACAGATTGTCCTGCTGAAGGATCAGAGGAAGTGCTTC
AGCATCGACAACCCCGGCTACGAGCCCGAAGTTGTGGCAGTGCACCCCGGCGGGGACACGGTGGCAATTGGGGGTGTGGACGGCAACGTC
CGCCTGTATTCCATCCTGGGCACCACGCTGAAGGATGAGGGCAAGCTCCTAGAGGCCAAGGGCCCCGTGACCGACGTGGCCTACTCCCAC
GACGGCGCCTTCCTCGCGGTGTGCGACGCCAGCAAGGTGGTCACAGTGTTCAGCGTTGCTGACGGCTACTCGGAGAACAATGTTTTTTAT
GGACACCATGCAAAAATCGTCTGCCTGGCCTGGTCCCCAGACAATGAACACTTTGCCTCCGGTGGCATGGACATGATGGTGTATGTTTGG
ACCCTGAGTGACCCGGAAACCAGAGTCAAGATCCAAGATGCACACCGGCTGCACCATGTCAGCAGCCTGGCCTGGCTGGACGAGCACACG
CTGGTCACGACCTCCCATGATGCCTCTGTCAAGGAGTGGACAATCACCTACTGAGGAGCCCCACCCCCGCCTCTGGATGGACCGAATCAG
GGACTAGAGTTTAACTGCAGCGGAACATGTCATTTCTCTATTTCTGTGACGCGCCCCCATGCCCCCACCCCACCACAAGAGGCAGGAGGG
CCCAGTCATGACCCTCGTCTCTGCAGGGTGTCTGTACACGTTCTTCTGAAAGCTTTAGACAGTAACAGTTTGCACATGAAAAATAAAGCG
AGCACCTAAACAATGTGTGGAGCATAACTAAAACCCACAGCCCAACCAAACCTTGAGAATGCGAAACATTCCAGAGGCAGTAGCCTCCAA
AGCACACAGAGCCCCTGGCCCCGCCGCGGCTCTCACTATCTGTCAGGGGAGGTTGTACAGGTGAATGAGCCGGGGGGCTCATGTTCCTGC
CTGCAGAACATTTCTGTACTAGTGAGAAGAGGGAATATGCATTGCAGTTCAGCAAAGCCGGAATTCTGTGTTGAACAGATGTCTGTCTCC
CTAGTGTGTGACTCACACCTTGTGGCTGCCTTCAGAGCGCCACCTCCAGATCAGATGGGGACACACAACCCCTGGATATGTTTCATTGTC
AGATTTTGTGCTTGATTTTAAGAATGGAATTGTGGGTATCTTTCCTTTTTTTTTAATGTATCTTAACTGTTGCCTGTCAGTGTTTACAAA
CTAGTGCGTTGACGGCACCGTGTCCAAGTTTTTAGAACCCTTGTTAGCCAGACCGAGGTGTCCTGGTCACCGTTTCACCATCATGCTTTG
ATGTTCCCCTGTCTTTCCCTCTTCTGCTCTCAAGAGCAAAGGTTAATTTAAGGACAAAGATGAAGTCACTGTAAACTAATCTGTCATTGT
TTTTACCTTCCTTTTCTTTTTCAGTGCAGAAATTAAAAGTAAGTATAAAGCACCGTGATTGGGAGTGTTTTTGCGTGTGTCGGAATCACT
GGTAAATGTTGGCTGAGAACAATCCCTCCCCTTGCACTTGTGAAAACACTTTGAGCGCTTTAAGAGATTAGCCTGAGAAATAATTAAATA

>82069_82069_4_SKAP1-WDR1_SKAP1_chr17_46423266_ENST00000584924_WDR1_chr4_10117858_ENST00000382451_length(amino acids)=554AA_BP=93
MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDY
QDEEKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKA
HDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKS
IQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKC
VAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVAVHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGA
FLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQDAHRLHHVSSLAWLDEHTLVT

--------------------------------------------------------------
>82069_82069_5_SKAP1-WDR1_SKAP1_chr17_46423266_ENST00000584924_WDR1_chr4_10117858_ENST00000382452_length(transcript)=3222nt_BP=379nt
GAGGTACAGGTGCCTCGCGGTGCAGCCGGGTCGCCTTCCAGCCCGTCCGCCTCCCGACCAGGGCCCGCGCCCCGTCCCGCCTCTCTCCCG
CCCAGCCAAATGCAGGCCGCCGCCCTCCCTGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAAT
GAGAACCTCAGCGCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAG
CCCCAAGGGGGAGACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTG
TCAGATTATCAGGATGAGGAGAAGGTGTTCGCCAGCCTCCCGCAGGTGGAGAGGGGCGTCTCCAAGATCATCGGCGGCGACCCTAAGGGC
AACAATTTTCTGTACACCAATGGAAAGTGCGTCATCCTAAGGAACATCGACAACCCAGCCCTTGCTGACATCTACACAGAGCACGCCCAT
CAGGTGGTGGTGGCCAAGTATGCGCCCAGCGGATTCTACATTGCCTCCGGAGATGTGTCTGGGAAGCTGAGGATCTGGGATACCACGCAG
AAGGAGCACCTGTTGAAGTATGAGTACCAGCCTTTCGCTGGGAAGATCAAAGACATTGCTTGGACTGAAGACAGTAAGAGGATCGCCGTG
GTCGGGGAAGGAAGGGAGAAGTTTGGAGCAGTCTTCCTCTGGGATAGTGGCTCTTCTGTGGGCGAGATTACAGGACACAACAAAGTCATC
AACAGCGTGGACATCAAGCAGAGCCGGCCATACCGGCTGGCCACGGGAAGCGATGATAACTGCGCGGCATTCTTTGAGGGACCCCCATTC
AAGTTCAAGTTCACAATTGGCGACCACAGCCGCTTTGTCAACTGTGTGCGATTCTCTCCTGATGGGAACAGATTTGCCACAGCCAGTGCT
GACGGCCAGATATACATCTATGACGGGAAGACTGGGGAGAAGGTGTGCGCGCTGGGCGGAAGCAAGGCCCACGACGGTGGGATTTACGCA
ATTAGTTGGAGTCCCGACAGCACCCATTTGCTTTCTGCTTCTGGGGACAAAACTTCCAAGATTTGGGACGTCAGCGTGAACTCCGTGGTC
AGCACATTTCCCATGGGCTCCACGGTTCTGGACCAGCAGCTGGGCTGCCTATGGCAGAAGGACCACCTGCTCAGTGTCTCCCTGTCCGGG
TACATCAACTATCTGGACAGAAACAACCCCAGCAAGCCCCTGCACGTCATCAAGGGTCACAGTAAATCGATCCAGTGTCTGACGGTGCAT
AAAAACGGCGGCAAGTCCTACATTTACTCTGGGAGCCACGACGGACACATTAATTACTGGGATTCAGAGACGGGGGAGAACGACTCCTTC
GCTGGGAAAGGCCACACGAACCAGGTGTCCAGGATGACCGTGGATGAGTCGGGGCAGCTCATCAGCTGCAGCATGGACGACACCGTGCGG
TACACCAGCCTCATGCTGCGGGACTACAGCGGACAAGGAGTTGTGAAACTGGACGTTCAGCCAAAGTGCGTAGCCGTCGGCCCCGGGGGA
TACGCCGTGGTCGTGTGCATTGGACAGATTGTCCTGCTGAAGGATCAGAGGAAGTGCTTCAGCATCGACAACCCCGGCTACGAGCCCGAA
GTTGTGGCAGTGCACCCCGGCGGGGACACGGTGGCAATTGGGGGTGTGGACGGCAACGTCCGCCTGTATTCCATCCTGGGCACCACGCTG
AAGGATGAGGGCAAGCTCCTAGAGGCCAAGGGCCCCGTGACCGACGTGGCCTACTCCCACGACGGCGCCTTCCTCGCGGTGTGCGACGCC
AGCAAGGTGGTCACAGTGTTCAGCGTTGCTGACGGCTACTCGGAGAACAATGTTTTTTATGGACACCATGCAAAAATCGTCTGCCTGGCC
TGGTCCCCAGACAATGAACACTTTGCCTCCGGTGGCATGGACATGATGGTGTATGTTTGGACCCTGAGTGACCCGGAAACCAGAGTCAAG
ATCCAAGATGCACACCGGCTGCACCATGTCAGCAGCCTGGCCTGGCTGGACGAGCACACGCTGGTCACGACCTCCCATGATGCCTCTGTC
AAGGAGTGGACAATCACCTACTGAGGAGCCCCACCCCCGCCTCTGGATGGACCGAATCAGGGACTAGAGTTTAACTGCAGCGGAACATGT
CATTTCTCTATTTCTGTGACGCGCCCCCATGCCCCCACCCCACCACAAGAGGCAGGAGGGCCCAGTCATGACCCTCGTCTCTGCAGGGTG
TCTGTACACGTTCTTCTGAAAGCTTTAGACAGTAACAGTTTGCACATGAAAAATAAAGCGAGCACCTAAACAATGTGTGGAGCATAACTA
AAACCCACAGCCCAACCAAACCTTGAGAATGCGAAACATTCCAGAGGCAGTAGCCTCCAAAGCACACAGAGCCCCTGGCCCCGCCGCGGC
TCTCACTATCTGTCAGGGGAGGTTGTACAGGTGAATGAGCCGGGGGGCTCATGTTCCTGCCTGCAGAACATTTCTGTACTAGTGAGAAGA
GGGAATATGCATTGCAGTTCAGCAAAGCCGGAATTCTGTGTTGAACAGATGTCTGTCTCCCTAGTGTGTGACTCACACCTTGTGGCTGCC
TTCAGAGCGCCACCTCCAGATCAGATGGGGACACACAACCCCTGGATATGTTTCATTGTCAGATTTTGTGCTTGATTTTAAGAATGGAAT
TGTGGGTATCTTTCCTTTTTTTTTAATGTATCTTAACTGTTGCCTGTCAGTGTTTACAAACTAGTGCGTTGACGGCACCGTGTCCAAGTT
TTTAGAACCCTTGTTAGCCAGACCGAGGTGTCCTGGTCACCGTTTCACCATCATGCTTTGATGTTCCCCTGTCTTTCCCTCTTCTGCTCT
CAAGAGCAAAGGTTAATTTAAGGACAAAGATGAAGTCACTGTAAACTAATCTGTCATTGTTTTTACCTTCCTTTTCTTTTTCAGTGCAGA
AATTAAAAGTAAGTATAAAGCACCGTGATTGGGAGTGTTTTTGCGTGTGTCGGAATCACTGGTAAATGTTGGCTGAGAACAATCCCTCCC

>82069_82069_5_SKAP1-WDR1_SKAP1_chr17_46423266_ENST00000584924_WDR1_chr4_10117858_ENST00000382452_length(amino acids)=694AA_BP=93
MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDY
QDEEKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEH
LLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFK
FTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTF
PMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGK
GHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVA
VHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSP

--------------------------------------------------------------
>82069_82069_6_SKAP1-WDR1_SKAP1_chr17_46423266_ENST00000584924_WDR1_chr4_10117858_ENST00000499869_length(transcript)=3223nt_BP=379nt
GAGGTACAGGTGCCTCGCGGTGCAGCCGGGTCGCCTTCCAGCCCGTCCGCCTCCCGACCAGGGCCCGCGCCCCGTCCCGCCTCTCTCCCG
CCCAGCCAAATGCAGGCCGCCGCCCTCCCTGAGGAGATCCGTTGGCTCCTGGAAGATGCTGAAGAGTTTCTGGCAGAAGGTTTGCGGAAT
GAGAACCTCAGCGCTGTTGCAAGGGATCACAGAGACCATATTCTACGGGGCTTTCAGCAAATCAAAGCCAGGTACTATTGGGATTTTCAG
CCCCAAGGGGGAGACATTGGACAGGACAGCTCTGATGATAATCACAGCGGGACTCTTGGCCTGTCCCTCACATCCGATGCACCCTTTTTG
TCAGATTATCAGGATGAGGAGAAGGTGTTCGCCAGCCTCCCGCAGGTGGAGAGGGGCGTCTCCAAGATCATCGGCGGCGACCCTAAGGGC
AACAATTTTCTGTACACCAATGGAAAGTGCGTCATCCTAAGGAACATCGACAACCCAGCCCTTGCTGACATCTACACAGAGCACGCCCAT
CAGGTGGTGGTGGCCAAGTATGCGCCCAGCGGATTCTACATTGCCTCCGGAGATGTGTCTGGGAAGCTGAGGATCTGGGATACCACGCAG
AAGGAGCACCTGTTGAAGTATGAGTACCAGCCTTTCGCTGGGAAGATCAAAGACATTGCTTGGACTGAAGACAGTAAGAGGATCGCCGTG
GTCGGGGAAGGAAGGGAGAAGTTTGGAGCAGTCTTCCTCTGGGATAGTGGCTCTTCTGTGGGCGAGATTACAGGACACAACAAAGTCATC
AACAGCGTGGACATCAAGCAGAGCCGGCCATACCGGCTGGCCACGGGAAGCGATGATAACTGCGCGGCATTCTTTGAGGGACCCCCATTC
AAGTTCAAGTTCACAATTGGCGACCACAGCCGCTTTGTCAACTGTGTGCGATTCTCTCCTGATGGGAACAGATTTGCCACAGCCAGTGCT
GACGGCCAGATATACATCTATGACGGGAAGACTGGGGAGAAGGTGTGCGCGCTGGGCGGAAGCAAGGCCCACGACGGTGGGATTTACGCA
ATTAGTTGGAGTCCCGACAGCACCCATTTGCTTTCTGCTTCTGGGGACAAAACTTCCAAGATTTGGGACGTCAGCGTGAACTCCGTGGTC
AGCACATTTCCCATGGGCTCCACGGTTCTGGACCAGCAGCTGGGCTGCCTATGGCAGAAGGACCACCTGCTCAGTGTCTCCCTGTCCGGG
TACATCAACTATCTGGACAGAAACAACCCCAGCAAGCCCCTGCACGTCATCAAGGGTCACAGTAAATCGATCCAGTGTCTGACGGTGCAT
AAAAACGGCGGCAAGTCCTACATTTACTCTGGGAGCCACGACGGACACATTAATTACTGGGATTCAGAGACGGGGGAGAACGACTCCTTC
GCTGGGAAAGGCCACACGAACCAGGTGTCCAGGATGACCGTGGATGAGTCGGGGCAGCTCATCAGCTGCAGCATGGACGACACCGTGCGG
TACACCAGCCTCATGCTGCGGGACTACAGCGGACAAGGAGTTGTGAAACTGGACGTTCAGCCAAAGTGCGTAGCCGTCGGCCCCGGGGGA
TACGCCGTGGTCGTGTGCATTGGACAGATTGTCCTGCTGAAGGATCAGAGGAAGTGCTTCAGCATCGACAACCCCGGCTACGAGCCCGAA
GTTGTGGCAGTGCACCCCGGCGGGGACACGGTGGCAATTGGGGGTGTGGACGGCAACGTCCGCCTGTATTCCATCCTGGGCACCACGCTG
AAGGATGAGGGCAAGCTCCTAGAGGCCAAGGGCCCCGTGACCGACGTGGCCTACTCCCACGACGGCGCCTTCCTCGCGGTGTGCGACGCC
AGCAAGGTGGTCACAGTGTTCAGCGTTGCTGACGGCTACTCGGAGAACAATGTTTTTTATGGACACCATGCAAAAATCGTCTGCCTGGCC
TGGTCCCCAGACAATGAACACTTTGCCTCCGGTGGCATGGACATGATGGTGTATGTTTGGACCCTGAGTGACCCGGAAACCAGAGTCAAG
ATCCAAGATGCACACCGGCTGCACCATGTCAGCAGCCTGGCCTGGCTGGACGAGCACACGCTGGTCACGACCTCCCATGATGCCTCTGTC
AAGGAGTGGACAATCACCTACTGAGGAGCCCCACCCCCGCCTCTGGATGGACCGAATCAGGGACTAGAGTTTAACTGCAGCGGAACATGT
CATTTCTCTATTTCTGTGACGCGCCCCCATGCCCCCACCCCACCACAAGAGGCAGGAGGGCCCAGTCATGACCCTCGTCTCTGCAGGGTG
TCTGTACACGTTCTTCTGAAAGCTTTAGACAGTAACAGTTTGCACATGAAAAATAAAGCGAGCACCTAAACAATGTGTGGAGCATAACTA
AAACCCACAGCCCAACCAAACCTTGAGAATGCGAAACATTCCAGAGGCAGTAGCCTCCAAAGCACACAGAGCCCCTGGCCCCGCCGCGGC
TCTCACTATCTGTCAGGGGAGGTTGTACAGGTGAATGAGCCGGGGGGCTCATGTTCCTGCCTGCAGAACATTTCTGTACTAGTGAGAAGA
GGGAATATGCATTGCAGTTCAGCAAAGCCGGAATTCTGTGTTGAACAGATGTCTGTCTCCCTAGTGTGTGACTCACACCTTGTGGCTGCC
TTCAGAGCGCCACCTCCAGATCAGATGGGGACACACAACCCCTGGATATGTTTCATTGTCAGATTTTGTGCTTGATTTTAAGAATGGAAT
TGTGGGTATCTTTCCTTTTTTTTTAATGTATCTTAACTGTTGCCTGTCAGTGTTTACAAACTAGTGCGTTGACGGCACCGTGTCCAAGTT
TTTAGAACCCTTGTTAGCCAGACCGAGGTGTCCTGGTCACCGTTTCACCATCATGCTTTGATGTTCCCCTGTCTTTCCCTCTTCTGCTCT
CAAGAGCAAAGGTTAATTTAAGGACAAAGATGAAGTCACTGTAAACTAATCTGTCATTGTTTTTACCTTCCTTTTCTTTTTCAGTGCAGA
AATTAAAAGTAAGTATAAAGCACCGTGATTGGGAGTGTTTTTGCGTGTGTCGGAATCACTGGTAAATGTTGGCTGAGAACAATCCCTCCC

>82069_82069_6_SKAP1-WDR1_SKAP1_chr17_46423266_ENST00000584924_WDR1_chr4_10117858_ENST00000499869_length(amino acids)=694AA_BP=93
MQAAALPEEIRWLLEDAEEFLAEGLRNENLSAVARDHRDHILRGFQQIKARYYWDFQPQGGDIGQDSSDDNHSGTLGLSLTSDAPFLSDY
QDEEKVFASLPQVERGVSKIIGGDPKGNNFLYTNGKCVILRNIDNPALADIYTEHAHQVVVAKYAPSGFYIASGDVSGKLRIWDTTQKEH
LLKYEYQPFAGKIKDIAWTEDSKRIAVVGEGREKFGAVFLWDSGSSVGEITGHNKVINSVDIKQSRPYRLATGSDDNCAAFFEGPPFKFK
FTIGDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTF
PMGSTVLDQQLGCLWQKDHLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGGKSYIYSGSHDGHINYWDSETGENDSFAGK
GHTNQVSRMTVDESGQLISCSMDDTVRYTSLMLRDYSGQGVVKLDVQPKCVAVGPGGYAVVVCIGQIVLLKDQRKCFSIDNPGYEPEVVA
VHPGGDTVAIGGVDGNVRLYSILGTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGYSENNVFYGHHAKIVCLAWSP

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Fusion Gene PPI Analysis for SKAP1-WDR1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneSKAP1chr17:46423266chr4:10117858ENST00000336915-413290_29593.33333333333333448.0FYB1
HgeneSKAP1chr17:46423266chr4:10117858ENST00000584924-412290_29593.33333333333333360.0FYB1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SKAP1-WDR1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SKAP1-WDR1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource