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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SKI-ATAD3A (FusionGDB2 ID:82081)

Fusion Gene Summary for SKI-ATAD3A

Fusion gene summary

Fusion gene information	Fusion gene name: SKI-ATAD3A
	Fusion gene ID: 82081
		Hgene	Tgene
	Gene symbol	SKI	ATAD3A
	Gene ID	6497	55210
	Gene name	SKI proto-oncogene	ATPase family AAA domain containing 3A
	Synonyms	SGS\|SKV	HAYOS
	Cytomap	1p36.33-p36.32	1p36.33
	Type of gene	protein-coding	protein-coding
	Description	ski oncogeneproto-oncogene c-Skiski oncoproteinv-ski avian sarcoma viral oncogene homolog	ATPase family AAA domain-containing protein 3A
	Modification date	20200329	20200320
	UniProtAcc	SKI	Q9NVI7
	Ensembl transtripts involved in fusion gene	ENST00000378536, ENST00000478223,	ENST00000378755, ENST00000378756, ENST00000536055,
Fusion gene scores	* DoF score	14 X 8 X 8=896	5 X 5 X 4=100
	# samples	17	5
	** MAII score	log2(17/896*10)=-2.3979639859199 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SKI [Title/Abstract] AND ATAD3A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SKI(2161174)-ATAD3A(1454301), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SKI	GO:0000122	negative regulation of transcription by RNA polymerase II	17469184
Hgene	SKI	GO:0008285	negative regulation of cell proliferation	11430826
Hgene	SKI	GO:0014902	myotube differentiation	19008232
Hgene	SKI	GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway	17469184
Hgene	SKI	GO:0030514	negative regulation of BMP signaling pathway	14699069
Hgene	SKI	GO:0032926	negative regulation of activin receptor signaling pathway	14699069
Hgene	SKI	GO:0043388	positive regulation of DNA binding	15107821
Hgene	SKI	GO:0045668	negative regulation of osteoblast differentiation	14699069
Hgene	SKI	GO:0060395	SMAD protein signal transduction	12874272

Fusion gene breakpoints across SKI (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ATAD3A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-N5-A59F-01A	SKI	chr1	2161174	+	ATAD3A	chr1	1454301	+
ChimerDB4	UCS	TCGA-N5-A59F	SKI	chr1	2161174	+	ATAD3A	chr1	1454301	+

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Fusion Gene ORF analysis for SKI-ATAD3A

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000378536	ENST00000378755	SKI	chr1	2161174	+	ATAD3A	chr1	1454301	+
In-frame	ENST00000378536	ENST00000378756	SKI	chr1	2161174	+	ATAD3A	chr1	1454301	+
In-frame	ENST00000378536	ENST00000536055	SKI	chr1	2161174	+	ATAD3A	chr1	1454301	+
intron-3CDS	ENST00000478223	ENST00000378755	SKI	chr1	2161174	+	ATAD3A	chr1	1454301	+
intron-3CDS	ENST00000478223	ENST00000378756	SKI	chr1	2161174	+	ATAD3A	chr1	1454301	+
intron-3CDS	ENST00000478223	ENST00000536055	SKI	chr1	2161174	+	ATAD3A	chr1	1454301	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000378536

SKI

chr1

2161174

ENST00000378756

ATAD3A

chr1

1454301

2971

1041

2357

761

ENST00000378536

SKI

chr1

2161174

ENST00000378755

ATAD3A

chr1

1454301

2971

1041

2357

761

ENST00000378536

SKI

chr1

2161174

ENST00000536055

ATAD3A

chr1

1454301

2973

1041

2357

761

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000378536	ENST00000378756	SKI	chr1	2161174	+	ATAD3A	chr1	1454301	+	0.022435093	0.97756493
ENST00000378536	ENST00000378755	SKI	chr1	2161174	+	ATAD3A	chr1	1454301	+	0.022435093	0.97756493
ENST00000378536	ENST00000536055	SKI	chr1	2161174	+	ATAD3A	chr1	1454301	+	0.022460729	0.9775393

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Fusion Genomic Features for SKI-ATAD3A

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SKI	chr1	2161174	+	ATAD3A	chr1	1454300	+	1.60E-09	1
SKI	chr1	2161174	+	ATAD3A	chr1	1454300	+	1.60E-09	1
SKI	chr1	2161174	+	ATAD3A	chr1	1454300	+	1.60E-09	1
SKI	chr1	2161174	+	ATAD3A	chr1	1454300	+	1.60E-09	1

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SKI-ATAD3A

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:2161174/chr1:1454301)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SKI SKI	ATAD3A Q9NVI7
908	FUNCTION: Essential for mitochondrial network organization, mitochondrial metabolism and cell growth at organism and cellular level. May play an important role in mitochondrial protein synthesis. May also participate in mitochondrial DNA replication. May bind to mitochondrial DNA D-loops and contribute to nucleoid stability. Required for enhanced channeling of cholesterol for hormone-dependent steroidogenesis. Involved in mitochondrial-mediated antiviral innate immunity (PubMed:31522117). {ECO:0000269\|PubMed:17210950, ECO:0000269\|PubMed:20154147, ECO:0000269\|PubMed:22453275, ECO:0000269\|PubMed:31522117}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000536055

139_267

508.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000378755

400_407

196

635.0

Nucleotide binding

ATP

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000378756

400_407

148

587.0

Nucleotide binding

ATP

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000536055

400_407

508.0

Nucleotide binding

ATP

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000378755

338_353

196

635.0

Region

Note=S100B-binding

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000378756

338_353

148

587.0

Region

Note=S100B-binding

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000536055

338_353

508.0

Region

Note=S100B-binding

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000378755

313_634

196

635.0

Topological domain

Mitochondrial matrix

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000378756

313_634

148

587.0

Topological domain

Mitochondrial matrix

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000536055

313_634

508.0

Topological domain

Mitochondrial matrix

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000378755

295_312

196

635.0

Transmembrane

Helical

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000378756

295_312

148

587.0

Transmembrane

Helical

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000536055

295_312

508.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SKI

chr1:2161174

chr1:1454301

ENST00000378536

536_710

323

729.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000378755

139_267

196

635.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000378756

139_267

148

587.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000378755

2_294

196

635.0

Topological domain

Mitochondrial intermembrane

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000378756

2_294

148

587.0

Topological domain

Mitochondrial intermembrane

Tgene

ATAD3A

chr1:2161174

chr1:1454301

ENST00000536055

2_294

508.0

Topological domain

Mitochondrial intermembrane

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Fusion Gene Sequence for SKI-ATAD3A

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>82081_82081_1_SKI-ATAD3A_SKI_chr1_2161174_ENST00000378536_ATAD3A_chr1_1454301_ENST00000378755_length(transcript)=2971nt_BP=1041nt
CGGGGCGGCGGCGGGGGCCGGGGGGGCCCGGGCGCGCGGGAGCGGGAGCGGCCGGGGGAGCCGGAGCGCACCATGGAGGCGGCGGCAGGC
GGCCGCGGCTGTTTCCAGCCGCACCCGGGGCTGCAGAAGACGCTGGAGCAGTTCCACCTGAGCTCCATGAGCTCGCTGGGCGGCCCGGCC
GCTTTCTCGGCGCGCTGGGCGCAGGAGGCCTACAAGAAGGAGAGCGCCAAGGAGGCGGGCGCGGCCGCGGTGCCGGCGCCGGTGCCCGCA
GCCACCGAGCCGCCGCCCGTGCTGCACCTGCCCGCCATCCAGCCGCCGCCGCCCGTGCTGCCCGGGCCCTTCTTCATGCCGTCCGACCGC
TCCACCGAGCGCTGCGAGACCGTACTGGAAGGCGAGACCATCTCGTGCTTCGTGGTGGGAGGCGAGAAGCGCCTGTGTCTGCCGCAGATT
CTCAACTCGGTGCTGCGCGACTTCTCGCTGCAGCAGATCAACGCGGTGTGCGACGAGCTCCACATCTACTGCTCGCGCTGCACGGCCGAC
CAGCTGGAGATCCTCAAAGTCATGGGCATCCTGCCCTTCTCGGCGCCCTCGTGCGGGCTCATCACCAAGACGGACGCCGAGCGCCTGTGC
AACGCGCTGCTCTACGGCGGCGCCTACCCGCCGCCCTGCAAGAAGGAGCTGGCCGCCAGCCTGGCGCTGGGCCTGGAGCTCAGCGAGCGC
AGCGTCCGCGTGTACCACGAGTGCTTCGGCAAGTGTAAGGGGCTGCTGGTGCCCGAGCTCTACAGCAGCCCGAGCGCCGCCTGCATCCAG
TGCCTGGACTGCCGCCTCATGTACCCGCCGCACAAGTTCGTGGTGCACTCGCACAAGGCCCTGGAGAACCGGACCTGCCACTGGGGCTTC
GACTCGGCCAACTGGCGGGCCTACATCCTGCTGAGCCAGGATTACACGGGCAAGGAGGAGCAGGCGCGCCTCGGCCGCTGCCTGGACGAC
GTGAAGGAGAAATTCGACTATGGCAACAAGTACAAGCGGCGGGTGCCCCGGCAACTTCTCAATGAGGAGAATTTACGGAAGCAGGAGGAG
TCCGTGCAGAAGCAGGAAGCCATGCGGCGAGCCACCGTGGAGCGGGAGATGGAGCTGCGGCACAAGAATGAGATGCTGCGAGTGGAGGCC
GAGGCCCGGGCGCGCGCCAAGGCCGAGCGGGAGAATGCAGACATCATCCGCGAGCAGATCCGCCTGAAGGCGGCCGAGCACCGTCAGACC
GTCTTGGAGTCCATCAGGACGGCTGGCACCTTGTTTGGGGAAGGATTCCGTGCCTTTGTGACAGACTGGGACAAAGTGACAGCCACGGTG
GCTGGGCTGACGCTGCTGGCTGTTGGGGTCTACTCAGCCAAGAATGCCACGCTTGTCGCCGGCCGCTTCATCGAGGCTCGGCTGGGGAAG
CCGTCCCTAGTGAGGGAGACGTCCCGCATCACGGTGCTTGAGGCGCTGCGGCACCCCATCCAGGTCAGCCGGCGGCTCCTCAGTCGACCC
CAGGACGCGCTGGAGGGTGTTGTGCTCAGTCCCAGCCTGGAAGCACGGGTGCGCGACATCGCCATAGCAACAAGGAACACCAAGAAGAAC
CGCAGCCTGTACAGGAACATCCTGATGTACGGGCCACCAGGCACCGGGAAGACGCTGTTTGCCAAGAAACTCGCCCTGCACTCAGGCATG
GACTACGCCATCATGACAGGCGGGGACGTGGCCCCCATGGGGCGGGAAGGCGTGACCGCCATGCACAAGCTCTTTGACTGGGCCAATACC
AGCCGGCGCGGCCTCCTGCTCTTTGTGGATGAAGCGGACGCCTTCCTTCGGAAGCGAGCCACCGAGAAGATAAGCGAGGACCTCAGGGCC
ACACTGAACGCCTTCCTGTACCGCACGGGCCAGCACAGCAACAAGTTCATGCTGGTCCTGGCCAGCAACCAACCAGAGCAGTTCGACTGG
GCCATCAATGACCGCATCAATGAGATGGTCCACTTCGACCTGCCAGGGCAGGAGGAACGGGAGCGCCTGGTGAGAATGTATTTTGACAAG
TATGTTCTTAAGCCGGCCACAGAAGGAAAGCAGCGCCTGAAGCTGGCCCAGTTTGACTACGGGAGGAAGTGCTCGGAGGTCGCTCGGCTG
ACGGAGGGCATGTCGGGCCGGGAGATCGCTCAGCTGGCCGTGTCCTGGCAGGCCACGGCGTATGCCTCCGAGGACGGGGTCCTGACCGAG
GCCATGATGGACACCCGCGTGCAAGATGCTGTCCAGCAGCACCAGCAGAAGATGTGCTGGCTGAAGGCGGAAGGGCCTGGGCGTGGGGAC
GAGCCCTCCCCATCCTGAGTCCACAGGGAGATCCACAGCTCACGGAGCCTGGCCGCGGACCCCTCCCACCCCTGCCTTGCCGGCCCCTGC
ACATTTAGGATATGCTCCTGGGTGGGGACTGGGCTGTGCCCAGGGCCTCTGTCCCCCAGGATGTCTTGTGGTGCGGGTCGGCCGTTCTGC
CCCCCAGGGCACCCCCTGTTGTAGGCACTGGCTAGGGAGGGGCAGGCCTCCTTCCTGCCCCTCGAGACACTCTTGGGAGATGCATTTTCC
GTCTGGCTCACAGGGGGAGGGTGAGGCTTTGCACCCCAGCCCCTGCCCAGGCCACTGTGAGGGTGGGTGCTGGCTGAGCCCCCGGGGCAG
CAGGAGCCAGGCAGGTGATGTCTTTGTTCTCGGCTCCCACAGCAGAGCCAGGTGAGGGGGCGCCTGCCAGGGCCAGACCCAGGTGGGGCA
GCCTGAACCCTGCTTCCCCCTGTGGCCGGCATGCCCCGATCTTTCACACACTGGTGACCCTGAGAGAGGAGGGAGGAGGGAACCTGGCGG
GGGTGTCTGAGGCCGCACTGTCAGCTGGCCGGTCCAAGCCTGTGGCTGGAGCTGGGGTCTGTTTACCTAATAAAGTCCCACAGGTGCCTC

>82081_82081_1_SKI-ATAD3A_SKI_chr1_2161174_ENST00000378536_ATAD3A_chr1_1454301_ENST00000378755_length(amino acids)=761AA_BP=323
MEAAAGGRGCFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPVLHLPAIQPPPPVLPGPF
FMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKT
DAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENR
TCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNE
MLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFI
EARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKL
ALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQ
PEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASE

--------------------------------------------------------------
>82081_82081_2_SKI-ATAD3A_SKI_chr1_2161174_ENST00000378536_ATAD3A_chr1_1454301_ENST00000378756_length(transcript)=2971nt_BP=1041nt
CGGGGCGGCGGCGGGGGCCGGGGGGGCCCGGGCGCGCGGGAGCGGGAGCGGCCGGGGGAGCCGGAGCGCACCATGGAGGCGGCGGCAGGC
GGCCGCGGCTGTTTCCAGCCGCACCCGGGGCTGCAGAAGACGCTGGAGCAGTTCCACCTGAGCTCCATGAGCTCGCTGGGCGGCCCGGCC
GCTTTCTCGGCGCGCTGGGCGCAGGAGGCCTACAAGAAGGAGAGCGCCAAGGAGGCGGGCGCGGCCGCGGTGCCGGCGCCGGTGCCCGCA
GCCACCGAGCCGCCGCCCGTGCTGCACCTGCCCGCCATCCAGCCGCCGCCGCCCGTGCTGCCCGGGCCCTTCTTCATGCCGTCCGACCGC
TCCACCGAGCGCTGCGAGACCGTACTGGAAGGCGAGACCATCTCGTGCTTCGTGGTGGGAGGCGAGAAGCGCCTGTGTCTGCCGCAGATT
CTCAACTCGGTGCTGCGCGACTTCTCGCTGCAGCAGATCAACGCGGTGTGCGACGAGCTCCACATCTACTGCTCGCGCTGCACGGCCGAC
CAGCTGGAGATCCTCAAAGTCATGGGCATCCTGCCCTTCTCGGCGCCCTCGTGCGGGCTCATCACCAAGACGGACGCCGAGCGCCTGTGC
AACGCGCTGCTCTACGGCGGCGCCTACCCGCCGCCCTGCAAGAAGGAGCTGGCCGCCAGCCTGGCGCTGGGCCTGGAGCTCAGCGAGCGC
AGCGTCCGCGTGTACCACGAGTGCTTCGGCAAGTGTAAGGGGCTGCTGGTGCCCGAGCTCTACAGCAGCCCGAGCGCCGCCTGCATCCAG
TGCCTGGACTGCCGCCTCATGTACCCGCCGCACAAGTTCGTGGTGCACTCGCACAAGGCCCTGGAGAACCGGACCTGCCACTGGGGCTTC
GACTCGGCCAACTGGCGGGCCTACATCCTGCTGAGCCAGGATTACACGGGCAAGGAGGAGCAGGCGCGCCTCGGCCGCTGCCTGGACGAC
GTGAAGGAGAAATTCGACTATGGCAACAAGTACAAGCGGCGGGTGCCCCGGCAACTTCTCAATGAGGAGAATTTACGGAAGCAGGAGGAG
TCCGTGCAGAAGCAGGAAGCCATGCGGCGAGCCACCGTGGAGCGGGAGATGGAGCTGCGGCACAAGAATGAGATGCTGCGAGTGGAGGCC
GAGGCCCGGGCGCGCGCCAAGGCCGAGCGGGAGAATGCAGACATCATCCGCGAGCAGATCCGCCTGAAGGCGGCCGAGCACCGTCAGACC
GTCTTGGAGTCCATCAGGACGGCTGGCACCTTGTTTGGGGAAGGATTCCGTGCCTTTGTGACAGACTGGGACAAAGTGACAGCCACGGTG
GCTGGGCTGACGCTGCTGGCTGTTGGGGTCTACTCAGCCAAGAATGCCACGCTTGTCGCCGGCCGCTTCATCGAGGCTCGGCTGGGGAAG
CCGTCCCTAGTGAGGGAGACGTCCCGCATCACGGTGCTTGAGGCGCTGCGGCACCCCATCCAGGTCAGCCGGCGGCTCCTCAGTCGACCC
CAGGACGCGCTGGAGGGTGTTGTGCTCAGTCCCAGCCTGGAAGCACGGGTGCGCGACATCGCCATAGCAACAAGGAACACCAAGAAGAAC
CGCAGCCTGTACAGGAACATCCTGATGTACGGGCCACCAGGCACCGGGAAGACGCTGTTTGCCAAGAAACTCGCCCTGCACTCAGGCATG
GACTACGCCATCATGACAGGCGGGGACGTGGCCCCCATGGGGCGGGAAGGCGTGACCGCCATGCACAAGCTCTTTGACTGGGCCAATACC
AGCCGGCGCGGCCTCCTGCTCTTTGTGGATGAAGCGGACGCCTTCCTTCGGAAGCGAGCCACCGAGAAGATAAGCGAGGACCTCAGGGCC
ACACTGAACGCCTTCCTGTACCGCACGGGCCAGCACAGCAACAAGTTCATGCTGGTCCTGGCCAGCAACCAACCAGAGCAGTTCGACTGG
GCCATCAATGACCGCATCAATGAGATGGTCCACTTCGACCTGCCAGGGCAGGAGGAACGGGAGCGCCTGGTGAGAATGTATTTTGACAAG
TATGTTCTTAAGCCGGCCACAGAAGGAAAGCAGCGCCTGAAGCTGGCCCAGTTTGACTACGGGAGGAAGTGCTCGGAGGTCGCTCGGCTG
ACGGAGGGCATGTCGGGCCGGGAGATCGCTCAGCTGGCCGTGTCCTGGCAGGCCACGGCGTATGCCTCCGAGGACGGGGTCCTGACCGAG
GCCATGATGGACACCCGCGTGCAAGATGCTGTCCAGCAGCACCAGCAGAAGATGTGCTGGCTGAAGGCGGAAGGGCCTGGGCGTGGGGAC
GAGCCCTCCCCATCCTGAGTCCACAGGGAGATCCACAGCTCACGGAGCCTGGCCGCGGACCCCTCCCACCCCTGCCTTGCCGGCCCCTGC
ACATTTAGGATATGCTCCTGGGTGGGGACTGGGCTGTGCCCAGGGCCTCTGTCCCCCAGGATGTCTTGTGGTGCGGGTCGGCCGTTCTGC
CCCCCAGGGCACCCCCTGTTGTAGGCACTGGCTAGGGAGGGGCAGGCCTCCTTCCTGCCCCTCGAGACACTCTTGGGAGATGCATTTTCC
GTCTGGCTCACAGGGGGAGGGTGAGGCTTTGCACCCCAGCCCCTGCCCAGGCCACTGTGAGGGTGGGTGCTGGCTGAGCCCCCGGGGCAG
CAGGAGCCAGGCAGGTGATGTCTTTGTTCTCGGCTCCCACAGCAGAGCCAGGTGAGGGGGCGCCTGCCAGGGCCAGACCCAGGTGGGGCA
GCCTGAACCCTGCTTCCCCCTGTGGCCGGCATGCCCCGATCTTTCACACACTGGTGACCCTGAGAGAGGAGGGAGGAGGGAACCTGGCGG
GGGTGTCTGAGGCCGCACTGTCAGCTGGCCGGTCCAAGCCTGTGGCTGGAGCTGGGGTCTGTTTACCTAATAAAGTCCCACAGGTGCCTC

>82081_82081_2_SKI-ATAD3A_SKI_chr1_2161174_ENST00000378536_ATAD3A_chr1_1454301_ENST00000378756_length(amino acids)=761AA_BP=323
MEAAAGGRGCFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPVLHLPAIQPPPPVLPGPF
FMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKT
DAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENR
TCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNE
MLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFI
EARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKL
ALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQ
PEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASE

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>82081_82081_3_SKI-ATAD3A_SKI_chr1_2161174_ENST00000378536_ATAD3A_chr1_1454301_ENST00000536055_length(transcript)=2973nt_BP=1041nt
CGGGGCGGCGGCGGGGGCCGGGGGGGCCCGGGCGCGCGGGAGCGGGAGCGGCCGGGGGAGCCGGAGCGCACCATGGAGGCGGCGGCAGGC
GGCCGCGGCTGTTTCCAGCCGCACCCGGGGCTGCAGAAGACGCTGGAGCAGTTCCACCTGAGCTCCATGAGCTCGCTGGGCGGCCCGGCC
GCTTTCTCGGCGCGCTGGGCGCAGGAGGCCTACAAGAAGGAGAGCGCCAAGGAGGCGGGCGCGGCCGCGGTGCCGGCGCCGGTGCCCGCA
GCCACCGAGCCGCCGCCCGTGCTGCACCTGCCCGCCATCCAGCCGCCGCCGCCCGTGCTGCCCGGGCCCTTCTTCATGCCGTCCGACCGC
TCCACCGAGCGCTGCGAGACCGTACTGGAAGGCGAGACCATCTCGTGCTTCGTGGTGGGAGGCGAGAAGCGCCTGTGTCTGCCGCAGATT
CTCAACTCGGTGCTGCGCGACTTCTCGCTGCAGCAGATCAACGCGGTGTGCGACGAGCTCCACATCTACTGCTCGCGCTGCACGGCCGAC
CAGCTGGAGATCCTCAAAGTCATGGGCATCCTGCCCTTCTCGGCGCCCTCGTGCGGGCTCATCACCAAGACGGACGCCGAGCGCCTGTGC
AACGCGCTGCTCTACGGCGGCGCCTACCCGCCGCCCTGCAAGAAGGAGCTGGCCGCCAGCCTGGCGCTGGGCCTGGAGCTCAGCGAGCGC
AGCGTCCGCGTGTACCACGAGTGCTTCGGCAAGTGTAAGGGGCTGCTGGTGCCCGAGCTCTACAGCAGCCCGAGCGCCGCCTGCATCCAG
TGCCTGGACTGCCGCCTCATGTACCCGCCGCACAAGTTCGTGGTGCACTCGCACAAGGCCCTGGAGAACCGGACCTGCCACTGGGGCTTC
GACTCGGCCAACTGGCGGGCCTACATCCTGCTGAGCCAGGATTACACGGGCAAGGAGGAGCAGGCGCGCCTCGGCCGCTGCCTGGACGAC
GTGAAGGAGAAATTCGACTATGGCAACAAGTACAAGCGGCGGGTGCCCCGGCAACTTCTCAATGAGGAGAATTTACGGAAGCAGGAGGAG
TCCGTGCAGAAGCAGGAAGCCATGCGGCGAGCCACCGTGGAGCGGGAGATGGAGCTGCGGCACAAGAATGAGATGCTGCGAGTGGAGGCC
GAGGCCCGGGCGCGCGCCAAGGCCGAGCGGGAGAATGCAGACATCATCCGCGAGCAGATCCGCCTGAAGGCGGCCGAGCACCGTCAGACC
GTCTTGGAGTCCATCAGGACGGCTGGCACCTTGTTTGGGGAAGGATTCCGTGCCTTTGTGACAGACTGGGACAAAGTGACAGCCACGGTG
GCTGGGCTGACGCTGCTGGCTGTTGGGGTCTACTCAGCCAAGAATGCCACGCTTGTCGCCGGCCGCTTCATCGAGGCTCGGCTGGGGAAG
CCGTCCCTAGTGAGGGAGACGTCCCGCATCACGGTGCTTGAGGCGCTGCGGCACCCCATCCAGGTCAGCCGGCGGCTCCTCAGTCGACCC
CAGGACGCGCTGGAGGGTGTTGTGCTCAGTCCCAGCCTGGAAGCACGGGTGCGCGACATCGCCATAGCAACAAGGAACACCAAGAAGAAC
CGCAGCCTGTACAGGAACATCCTGATGTACGGGCCACCAGGCACCGGGAAGACGCTGTTTGCCAAGAAACTCGCCCTGCACTCAGGCATG
GACTACGCCATCATGACAGGCGGGGACGTGGCCCCCATGGGGCGGGAAGGCGTGACCGCCATGCACAAGCTCTTTGACTGGGCCAATACC
AGCCGGCGCGGCCTCCTGCTCTTTGTGGATGAAGCGGACGCCTTCCTTCGGAAGCGAGCCACCGAGAAGATAAGCGAGGACCTCAGGGCC
ACACTGAACGCCTTCCTGTACCGCACGGGCCAGCACAGCAACAAGTTCATGCTGGTCCTGGCCAGCAACCAACCAGAGCAGTTCGACTGG
GCCATCAATGACCGCATCAATGAGATGGTCCACTTCGACCTGCCAGGGCAGGAGGAACGGGAGCGCCTGGTGAGAATGTATTTTGACAAG
TATGTTCTTAAGCCGGCCACAGAAGGAAAGCAGCGCCTGAAGCTGGCCCAGTTTGACTACGGGAGGAAGTGCTCGGAGGTCGCTCGGCTG
ACGGAGGGCATGTCGGGCCGGGAGATCGCTCAGCTGGCCGTGTCCTGGCAGGCCACGGCGTATGCCTCCGAGGACGGGGTCCTGACCGAG
GCCATGATGGACACCCGCGTGCAAGATGCTGTCCAGCAGCACCAGCAGAAGATGTGCTGGCTGAAGGCGGAAGGGCCTGGGCGTGGGGAC
GAGCCCTCCCCATCCTGAGTCCACAGGGAGATCCACAGCTCACGGAGCCTGGCCGCGGACCCCTCCCACCCCTGCCTTGCCGGCCCCTGC
ACATTTAGGATATGCTCCTGGGTGGGGACTGGGCTGTGCCCAGGGCCTCTGTCCCCCAGGATGTCTTGTGGTGCGGGTCGGCCGTTCTGC
CCCCCAGGGCACCCCCTGTTGTAGGCACTGGCTAGGGAGGGGCAGGCCTCCTTCCTGCCCCTCGAGACACTCTTGGGAGATGCATTTTCC
GTCTGGCTCACAGGGGGAGGGTGAGGCTTTGCACCCCAGCCCCTGCCCAGGCCACTGTGAGGGTGGGTGCTGGCTGAGCCCCCGGGGCAG
CAGGAGCCAGGCAGGTGATGTCTTTGTTCTCGGCTCCCACAGCAGAGCCAGGTGAGGGGGCGCCTGCCAGGGCCAGACCCAGGTGGGGCA
GCCTGAACCCTGCTTCCCCCTGTGGCCGGCATGCCCCGATCTTTCACACACTGGTGACCCTGAGAGAGGAGGGAGGAGGGAACCTGGCGG
GGGTGTCTGAGGCCGCACTGTCAGCTGGCCGGTCCAAGCCTGTGGCTGGAGCTGGGGTCTGTTTACCTAATAAAGTCCCACAGGTGCCTC

>82081_82081_3_SKI-ATAD3A_SKI_chr1_2161174_ENST00000378536_ATAD3A_chr1_1454301_ENST00000536055_length(amino acids)=761AA_BP=323
MEAAAGGRGCFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPVLHLPAIQPPPPVLPGPF
FMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKT
DAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENR
TCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRQLLNEENLRKQEESVQKQEAMRRATVEREMELRHKNE
MLRVEAEARARAKAERENADIIREQIRLKAAEHRQTVLESIRTAGTLFGEGFRAFVTDWDKVTATVAGLTLLAVGVYSAKNATLVAGRFI
EARLGKPSLVRETSRITVLEALRHPIQVSRRLLSRPQDALEGVVLSPSLEARVRDIAIATRNTKKNRSLYRNILMYGPPGTGKTLFAKKL
ALHSGMDYAIMTGGDVAPMGREGVTAMHKLFDWANTSRRGLLLFVDEADAFLRKRATEKISEDLRATLNAFLYRTGQHSNKFMLVLASNQ
PEQFDWAINDRINEMVHFDLPGQEERERLVRMYFDKYVLKPATEGKQRLKLAQFDYGRKCSEVARLTEGMSGREIAQLAVSWQATAYASE

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Top

Fusion Gene PPI Analysis for SKI-ATAD3A

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SKI-ATAD3A

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SKI-ATAD3A

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source