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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SKI-CAPZB (FusionGDB2 ID:82083)

Fusion Gene Summary for SKI-CAPZB

check button Fusion gene summary
Fusion gene informationFusion gene name: SKI-CAPZB
Fusion gene ID: 82083
HgeneTgene
Gene symbol

SKI

CAPZB

Gene ID

6497

832

Gene nameSKI proto-oncogenecapping actin protein of muscle Z-line subunit beta
SynonymsSGS|SKVCAPB|CAPPB|CAPZ
Cytomap

1p36.33-p36.32

1p36.13

Type of geneprotein-codingprotein-coding
Descriptionski oncogeneproto-oncogene c-Skiski oncoproteinv-ski avian sarcoma viral oncogene homologF-actin-capping protein subunit betacapZ betacapping actin protein of muscle Z-line beta subunitcapping protein (actin filament) muscle Z-line, betaepididymis secretory sperm binding protein
Modification date2020032920200320
UniProtAcc

SKI

P47756

Ensembl transtripts involved in fusion geneENST00000378536, ENST00000478223, 
ENST00000375144, ENST00000482808, 
ENST00000264202, ENST00000264203, 
ENST00000375142, ENST00000401084, 
ENST00000433834, 
Fusion gene scores* DoF score14 X 8 X 8=89623 X 15 X 8=2760
# samples 1727
** MAII scorelog2(17/896*10)=-2.3979639859199
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/2760*10)=-3.3536369546147
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SKI [Title/Abstract] AND CAPZB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSKI(2161174)-CAPZB(19746244), # samples:2
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSKI

GO:0000122

negative regulation of transcription by RNA polymerase II

17469184

HgeneSKI

GO:0008285

negative regulation of cell proliferation

11430826

HgeneSKI

GO:0014902

myotube differentiation

19008232

HgeneSKI

GO:0030512

negative regulation of transforming growth factor beta receptor signaling pathway

17469184

HgeneSKI

GO:0030514

negative regulation of BMP signaling pathway

14699069

HgeneSKI

GO:0032926

negative regulation of activin receptor signaling pathway

14699069

HgeneSKI

GO:0043388

positive regulation of DNA binding

15107821

HgeneSKI

GO:0045668

negative regulation of osteoblast differentiation

14699069

HgeneSKI

GO:0060395

SMAD protein signal transduction

12874272


check buttonFusion gene breakpoints across SKI (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CAPZB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A7EU-01ASKIchr1

2161174

-CAPZBchr1

19746244

-
ChimerDB4SARCTCGA-DX-A7EU-01ASKIchr1

2161174

+CAPZBchr1

19746244

-


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Fusion Gene ORF analysis for SKI-CAPZB

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000378536ENST00000375144SKIchr1

2161174

+CAPZBchr1

19746244

-
5CDS-5UTRENST00000378536ENST00000482808SKIchr1

2161174

+CAPZBchr1

19746244

-
In-frameENST00000378536ENST00000264202SKIchr1

2161174

+CAPZBchr1

19746244

-
In-frameENST00000378536ENST00000264203SKIchr1

2161174

+CAPZBchr1

19746244

-
In-frameENST00000378536ENST00000375142SKIchr1

2161174

+CAPZBchr1

19746244

-
In-frameENST00000378536ENST00000401084SKIchr1

2161174

+CAPZBchr1

19746244

-
In-frameENST00000378536ENST00000433834SKIchr1

2161174

+CAPZBchr1

19746244

-
intron-3CDSENST00000478223ENST00000264202SKIchr1

2161174

+CAPZBchr1

19746244

-
intron-3CDSENST00000478223ENST00000264203SKIchr1

2161174

+CAPZBchr1

19746244

-
intron-3CDSENST00000478223ENST00000375142SKIchr1

2161174

+CAPZBchr1

19746244

-
intron-3CDSENST00000478223ENST00000401084SKIchr1

2161174

+CAPZBchr1

19746244

-
intron-3CDSENST00000478223ENST00000433834SKIchr1

2161174

+CAPZBchr1

19746244

-
intron-5UTRENST00000478223ENST00000375144SKIchr1

2161174

+CAPZBchr1

19746244

-
intron-5UTRENST00000478223ENST00000482808SKIchr1

2161174

+CAPZBchr1

19746244

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000378536SKIchr12161174+ENST00000401084CAPZBchr119746244-26141041721856594
ENST00000378536SKIchr12161174+ENST00000264203CAPZBchr119746244-25341041721742556
ENST00000378536SKIchr12161174+ENST00000375142CAPZBchr119746244-26771041721871599
ENST00000378536SKIchr12161174+ENST00000433834CAPZBchr119746244-20281041721856594
ENST00000378536SKIchr12161174+ENST00000264202CAPZBchr119746244-18721041721871599

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000378536ENST00000401084SKIchr12161174+CAPZBchr119746244-0.0087321950.99126786
ENST00000378536ENST00000264203SKIchr12161174+CAPZBchr119746244-0.0137046230.9862954
ENST00000378536ENST00000375142SKIchr12161174+CAPZBchr119746244-0.0111599460.98884004
ENST00000378536ENST00000433834SKIchr12161174+CAPZBchr119746244-0.0307119470.969288
ENST00000378536ENST00000264202SKIchr12161174+CAPZBchr119746244-0.0292532980.97074676

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Fusion Genomic Features for SKI-CAPZB


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SKI-CAPZB


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:2161174/chr1:19746244)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SKI

SKI

CAPZB

P47756

908FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. {ECO:0000269|PubMed:21834987}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSKIchr1:2161174chr1:19746244ENST00000378536+17536_710323729.0Coiled coilOntology_term=ECO:0000255


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Fusion Gene Sequence for SKI-CAPZB


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>82083_82083_1_SKI-CAPZB_SKI_chr1_2161174_ENST00000378536_CAPZB_chr1_19746244_ENST00000264202_length(transcript)=1872nt_BP=1041nt
CGGGGCGGCGGCGGGGGCCGGGGGGGCCCGGGCGCGCGGGAGCGGGAGCGGCCGGGGGAGCCGGAGCGCACCATGGAGGCGGCGGCAGGC
GGCCGCGGCTGTTTCCAGCCGCACCCGGGGCTGCAGAAGACGCTGGAGCAGTTCCACCTGAGCTCCATGAGCTCGCTGGGCGGCCCGGCC
GCTTTCTCGGCGCGCTGGGCGCAGGAGGCCTACAAGAAGGAGAGCGCCAAGGAGGCGGGCGCGGCCGCGGTGCCGGCGCCGGTGCCCGCA
GCCACCGAGCCGCCGCCCGTGCTGCACCTGCCCGCCATCCAGCCGCCGCCGCCCGTGCTGCCCGGGCCCTTCTTCATGCCGTCCGACCGC
TCCACCGAGCGCTGCGAGACCGTACTGGAAGGCGAGACCATCTCGTGCTTCGTGGTGGGAGGCGAGAAGCGCCTGTGTCTGCCGCAGATT
CTCAACTCGGTGCTGCGCGACTTCTCGCTGCAGCAGATCAACGCGGTGTGCGACGAGCTCCACATCTACTGCTCGCGCTGCACGGCCGAC
CAGCTGGAGATCCTCAAAGTCATGGGCATCCTGCCCTTCTCGGCGCCCTCGTGCGGGCTCATCACCAAGACGGACGCCGAGCGCCTGTGC
AACGCGCTGCTCTACGGCGGCGCCTACCCGCCGCCCTGCAAGAAGGAGCTGGCCGCCAGCCTGGCGCTGGGCCTGGAGCTCAGCGAGCGC
AGCGTCCGCGTGTACCACGAGTGCTTCGGCAAGTGTAAGGGGCTGCTGGTGCCCGAGCTCTACAGCAGCCCGAGCGCCGCCTGCATCCAG
TGCCTGGACTGCCGCCTCATGTACCCGCCGCACAAGTTCGTGGTGCACTCGCACAAGGCCCTGGAGAACCGGACCTGCCACTGGGGCTTC
GACTCGGCCAACTGGCGGGCCTACATCCTGCTGAGCCAGGATTACACGGGCAAGGAGGAGCAGGCGCGCCTCGGCCGCTGCCTGGACGAC
GTGAAGGAGAAATTCGACTATGGCAACAAGTACAAGCGGCGGGTGCCCCGGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATGAGG
CGCCTGCCTCCCCAGCAAATCGAGAAAAACCTCAGCGACCTGATCGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGAC
CAGCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCA
TGGAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTT
GACCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATA
AAGAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACC
GCCCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACC
AGACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATC
AGAAGTACGCTGAACGAGATCTACTTTGGAAAAACAAAGGATATCGTCAATGGGCTGAGATCTATTGATGCTATCCCTGACAACCAAAAG

>82083_82083_1_SKI-CAPZB_SKI_chr1_2161174_ENST00000378536_CAPZB_chr1_19746244_ENST00000264202_length(amino acids)=599AA_BP=321
MEAAAGGRGCFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPVLHLPAIQPPPPVLPGPF
FMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKT
DAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENR
TCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCED
LLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGF
AGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVE

--------------------------------------------------------------
>82083_82083_2_SKI-CAPZB_SKI_chr1_2161174_ENST00000378536_CAPZB_chr1_19746244_ENST00000264203_length(transcript)=2534nt_BP=1041nt
CGGGGCGGCGGCGGGGGCCGGGGGGGCCCGGGCGCGCGGGAGCGGGAGCGGCCGGGGGAGCCGGAGCGCACCATGGAGGCGGCGGCAGGC
GGCCGCGGCTGTTTCCAGCCGCACCCGGGGCTGCAGAAGACGCTGGAGCAGTTCCACCTGAGCTCCATGAGCTCGCTGGGCGGCCCGGCC
GCTTTCTCGGCGCGCTGGGCGCAGGAGGCCTACAAGAAGGAGAGCGCCAAGGAGGCGGGCGCGGCCGCGGTGCCGGCGCCGGTGCCCGCA
GCCACCGAGCCGCCGCCCGTGCTGCACCTGCCCGCCATCCAGCCGCCGCCGCCCGTGCTGCCCGGGCCCTTCTTCATGCCGTCCGACCGC
TCCACCGAGCGCTGCGAGACCGTACTGGAAGGCGAGACCATCTCGTGCTTCGTGGTGGGAGGCGAGAAGCGCCTGTGTCTGCCGCAGATT
CTCAACTCGGTGCTGCGCGACTTCTCGCTGCAGCAGATCAACGCGGTGTGCGACGAGCTCCACATCTACTGCTCGCGCTGCACGGCCGAC
CAGCTGGAGATCCTCAAAGTCATGGGCATCCTGCCCTTCTCGGCGCCCTCGTGCGGGCTCATCACCAAGACGGACGCCGAGCGCCTGTGC
AACGCGCTGCTCTACGGCGGCGCCTACCCGCCGCCCTGCAAGAAGGAGCTGGCCGCCAGCCTGGCGCTGGGCCTGGAGCTCAGCGAGCGC
AGCGTCCGCGTGTACCACGAGTGCTTCGGCAAGTGTAAGGGGCTGCTGGTGCCCGAGCTCTACAGCAGCCCGAGCGCCGCCTGCATCCAG
TGCCTGGACTGCCGCCTCATGTACCCGCCGCACAAGTTCGTGGTGCACTCGCACAAGGCCCTGGAGAACCGGACCTGCCACTGGGGCTTC
GACTCGGCCAACTGGCGGGCCTACATCCTGCTGAGCCAGGATTACACGGGCAAGGAGGAGCAGGCGCGCCTCGGCCGCTGCCTGGACGAC
GTGAAGGAGAAATTCGACTATGGCAACAAGTACAAGCGGCGGGTGCCCCGGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATGAGG
CGCCTGCCTCCCCAGCAAATCGAGAAAAACCTCAGCGACCTGATCGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGAC
CAGCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCA
TGGAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTT
GACCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATA
AAGAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACC
GCCCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACC
AGACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGTCTGTGCAGACTTTTGC
AGACAAATCAAAACAAGAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACC
AGACACGCCGTGCACTCGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATA
ACAGCTGCATCATTGACCGCACAGCGCCATCTCTCCCTGAGAATAAAGCCGATAGCCACCCTCCTCCGGCTCCGAGCCTGCTTCTGCCAC
ACCTCGCTCTCAGTTCTCTCCACATTTCCATAGAGACCGTGTGGTTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCCTGTCCCCCCATTT
ATAGGCATAAAATCCACTGTCTGCCAGCCTCCCTTCCCTCCCACCTTTTTGGTACATTGGTGTAAAAAATGTAAAACAAAAAAATTTTAT
GAACTAACTGTGGTGTGTGAAAGAGAGAAGAAAAACTGGAAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGGGGGTCGTGGG
GACAGGGGACAGCTCTGGGAGCAGAGGTGGCCCTCGGTGCCGTCCTGCGCAGACTCTCCCGTCCCACGGAGGCCGCGGGGTGGGGGCTGG
GGGGGGTGCCGCCGACCGTTCCGCTCTTCCGGCCAGGTGCTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTGTTTTATTTTG
TTTTTTTGTAAAGCTTAAGAAAAAAATCTACATCTTATACTTGAGCCTCCATACTTAAAAAAAGAAAAGAAAAGAAATCAATAAAAAGAA

>82083_82083_2_SKI-CAPZB_SKI_chr1_2161174_ENST00000378536_CAPZB_chr1_19746244_ENST00000264203_length(amino acids)=556AA_BP=321
MEAAAGGRGCFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPVLHLPAIQPPPPVLPGPF
FMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKT
DAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENR
TCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCED
LLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGF
AGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVE

--------------------------------------------------------------
>82083_82083_3_SKI-CAPZB_SKI_chr1_2161174_ENST00000378536_CAPZB_chr1_19746244_ENST00000375142_length(transcript)=2677nt_BP=1041nt
CGGGGCGGCGGCGGGGGCCGGGGGGGCCCGGGCGCGCGGGAGCGGGAGCGGCCGGGGGAGCCGGAGCGCACCATGGAGGCGGCGGCAGGC
GGCCGCGGCTGTTTCCAGCCGCACCCGGGGCTGCAGAAGACGCTGGAGCAGTTCCACCTGAGCTCCATGAGCTCGCTGGGCGGCCCGGCC
GCTTTCTCGGCGCGCTGGGCGCAGGAGGCCTACAAGAAGGAGAGCGCCAAGGAGGCGGGCGCGGCCGCGGTGCCGGCGCCGGTGCCCGCA
GCCACCGAGCCGCCGCCCGTGCTGCACCTGCCCGCCATCCAGCCGCCGCCGCCCGTGCTGCCCGGGCCCTTCTTCATGCCGTCCGACCGC
TCCACCGAGCGCTGCGAGACCGTACTGGAAGGCGAGACCATCTCGTGCTTCGTGGTGGGAGGCGAGAAGCGCCTGTGTCTGCCGCAGATT
CTCAACTCGGTGCTGCGCGACTTCTCGCTGCAGCAGATCAACGCGGTGTGCGACGAGCTCCACATCTACTGCTCGCGCTGCACGGCCGAC
CAGCTGGAGATCCTCAAAGTCATGGGCATCCTGCCCTTCTCGGCGCCCTCGTGCGGGCTCATCACCAAGACGGACGCCGAGCGCCTGTGC
AACGCGCTGCTCTACGGCGGCGCCTACCCGCCGCCCTGCAAGAAGGAGCTGGCCGCCAGCCTGGCGCTGGGCCTGGAGCTCAGCGAGCGC
AGCGTCCGCGTGTACCACGAGTGCTTCGGCAAGTGTAAGGGGCTGCTGGTGCCCGAGCTCTACAGCAGCCCGAGCGCCGCCTGCATCCAG
TGCCTGGACTGCCGCCTCATGTACCCGCCGCACAAGTTCGTGGTGCACTCGCACAAGGCCCTGGAGAACCGGACCTGCCACTGGGGCTTC
GACTCGGCCAACTGGCGGGCCTACATCCTGCTGAGCCAGGATTACACGGGCAAGGAGGAGCAGGCGCGCCTCGGCCGCTGCCTGGACGAC
GTGAAGGAGAAATTCGACTATGGCAACAAGTACAAGCGGCGGGTGCCCCGGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATGAGG
CGCCTGCCTCCCCAGCAAATCGAGAAAAACCTCAGCGACCTGATCGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGAC
CAGCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCA
TGGAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTT
GACCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATA
AAGAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACC
GCCCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACC
AGACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATC
AGAAGTACGCTGAACGAGATCTACTTTGGAAAAACAAAGGATATCGTCAATGGGCTGAGATCTATTGATGCTATCCCTGACAACCAAAAG
TTTAAGCAGTTGCAGAGGGAGCTCTCTCAAGTGCTGACCCAGCGCCAGATCTACATCCAGCCTGATAATTAAGCCGATCCAGGTCTGTGC
AGACTTTTGCAGACAAATCAAAACAAGAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTT
CATGCTAACCAGACACGCCGTGCACTCGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGAC
AGGTCACATAACAGCTGCATCATTGACCGCACAGCGCCATCTCTCCCTGAGAATAAAGCCGATAGCCACCCTCCTCCGGCTCCGAGCCTG
CTTCTGCCACACCTCGCTCTCAGTTCTCTCCACATTTCCATAGAGACCGTGTGGTTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCCTGT
CCCCCCATTTATAGGCATAAAATCCACTGTCTGCCAGCCTCCCTTCCCTCCCACCTTTTTGGTACATTGGTGTAAAAAATGTAAAACAAA
AAAATTTTATGAACTAACTGTGGTGTGTGAAAGAGAGAAGAAAAACTGGAAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGG
GGGTCGTGGGGACAGGGGACAGCTCTGGGAGCAGAGGTGGCCCTCGGTGCCGTCCTGCGCAGACTCTCCCGTCCCACGGAGGCCGCGGGG
TGGGGGCTGGGGGGGGTGCCGCCGACCGTTCCGCTCTTCCGGCCAGGTGCTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTG

>82083_82083_3_SKI-CAPZB_SKI_chr1_2161174_ENST00000378536_CAPZB_chr1_19746244_ENST00000375142_length(amino acids)=599AA_BP=321
MEAAAGGRGCFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPVLHLPAIQPPPPVLPGPF
FMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKT
DAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENR
TCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCED
LLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGF
AGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVE

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>82083_82083_4_SKI-CAPZB_SKI_chr1_2161174_ENST00000378536_CAPZB_chr1_19746244_ENST00000401084_length(transcript)=2614nt_BP=1041nt
CGGGGCGGCGGCGGGGGCCGGGGGGGCCCGGGCGCGCGGGAGCGGGAGCGGCCGGGGGAGCCGGAGCGCACCATGGAGGCGGCGGCAGGC
GGCCGCGGCTGTTTCCAGCCGCACCCGGGGCTGCAGAAGACGCTGGAGCAGTTCCACCTGAGCTCCATGAGCTCGCTGGGCGGCCCGGCC
GCTTTCTCGGCGCGCTGGGCGCAGGAGGCCTACAAGAAGGAGAGCGCCAAGGAGGCGGGCGCGGCCGCGGTGCCGGCGCCGGTGCCCGCA
GCCACCGAGCCGCCGCCCGTGCTGCACCTGCCCGCCATCCAGCCGCCGCCGCCCGTGCTGCCCGGGCCCTTCTTCATGCCGTCCGACCGC
TCCACCGAGCGCTGCGAGACCGTACTGGAAGGCGAGACCATCTCGTGCTTCGTGGTGGGAGGCGAGAAGCGCCTGTGTCTGCCGCAGATT
CTCAACTCGGTGCTGCGCGACTTCTCGCTGCAGCAGATCAACGCGGTGTGCGACGAGCTCCACATCTACTGCTCGCGCTGCACGGCCGAC
CAGCTGGAGATCCTCAAAGTCATGGGCATCCTGCCCTTCTCGGCGCCCTCGTGCGGGCTCATCACCAAGACGGACGCCGAGCGCCTGTGC
AACGCGCTGCTCTACGGCGGCGCCTACCCGCCGCCCTGCAAGAAGGAGCTGGCCGCCAGCCTGGCGCTGGGCCTGGAGCTCAGCGAGCGC
AGCGTCCGCGTGTACCACGAGTGCTTCGGCAAGTGTAAGGGGCTGCTGGTGCCCGAGCTCTACAGCAGCCCGAGCGCCGCCTGCATCCAG
TGCCTGGACTGCCGCCTCATGTACCCGCCGCACAAGTTCGTGGTGCACTCGCACAAGGCCCTGGAGAACCGGACCTGCCACTGGGGCTTC
GACTCGGCCAACTGGCGGGCCTACATCCTGCTGAGCCAGGATTACACGGGCAAGGAGGAGCAGGCGCGCCTCGGCCGCTGCCTGGACGAC
GTGAAGGAGAAATTCGACTATGGCAACAAGTACAAGCGGCGGGTGCCCCGGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATGAGG
CGCCTGCCTCCCCAGCAAATCGAGAAAAACCTCAGCGACCTGATCGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGAC
CAGCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCA
TGGAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTT
GACCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATA
AAGAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACC
GCCCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACC
AGACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATC
AGAAGTACGCTGAACGAGATCTACTTTGGAAAAACAAAGGATATCGTCAATGGGCTGAGGTCTGTGCAGACTTTTGCAGACAAATCAAAA
CAAGAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACGCCGTGC
ACTCGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTGCATCAT
TGACCGCACAGCGCCATCTCTCCCTGAGAATAAAGCCGATAGCCACCCTCCTCCGGCTCCGAGCCTGCTTCTGCCACACCTCGCTCTCAG
TTCTCTCCACATTTCCATAGAGACCGTGTGGTTTTTGTTCACCCGGGCCCCCCGTCTTCCTCCCTGTCCCCCCATTTATAGGCATAAAAT
CCACTGTCTGCCAGCCTCCCTTCCCTCCCACCTTTTTGGTACATTGGTGTAAAAAATGTAAAACAAAAAAATTTTATGAACTAACTGTGG
TGTGTGAAAGAGAGAAGAAAAACTGGAAATCTTATTCCGTGTGTGTTTGGGAGTTGCTTGGGGTTGGGGGTCGTGGGGACAGGGGACAGC
TCTGGGAGCAGAGGTGGCCCTCGGTGCCGTCCTGCGCAGACTCTCCCGTCCCACGGAGGCCGCGGGGTGGGGGCTGGGGGGGGTGCCGCC
GACCGTTCCGCTCTTCCGGCCAGGTGCTTTTCTGTCAATTTCTATGGAATGCAAAAGGAGGTTTTTGTTTTATTTTGTTTTTTTGTAAAG
CTTAAGAAAAAAATCTACATCTTATACTTGAGCCTCCATACTTAAAAAAAGAAAAGAAAAGAAATCAATAAAAAGAAACTGGGGCGCAGT

>82083_82083_4_SKI-CAPZB_SKI_chr1_2161174_ENST00000378536_CAPZB_chr1_19746244_ENST00000401084_length(amino acids)=594AA_BP=321
MEAAAGGRGCFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPVLHLPAIQPPPPVLPGPF
FMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKT
DAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENR
TCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCED
LLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGF
AGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVE

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>82083_82083_5_SKI-CAPZB_SKI_chr1_2161174_ENST00000378536_CAPZB_chr1_19746244_ENST00000433834_length(transcript)=2028nt_BP=1041nt
CGGGGCGGCGGCGGGGGCCGGGGGGGCCCGGGCGCGCGGGAGCGGGAGCGGCCGGGGGAGCCGGAGCGCACCATGGAGGCGGCGGCAGGC
GGCCGCGGCTGTTTCCAGCCGCACCCGGGGCTGCAGAAGACGCTGGAGCAGTTCCACCTGAGCTCCATGAGCTCGCTGGGCGGCCCGGCC
GCTTTCTCGGCGCGCTGGGCGCAGGAGGCCTACAAGAAGGAGAGCGCCAAGGAGGCGGGCGCGGCCGCGGTGCCGGCGCCGGTGCCCGCA
GCCACCGAGCCGCCGCCCGTGCTGCACCTGCCCGCCATCCAGCCGCCGCCGCCCGTGCTGCCCGGGCCCTTCTTCATGCCGTCCGACCGC
TCCACCGAGCGCTGCGAGACCGTACTGGAAGGCGAGACCATCTCGTGCTTCGTGGTGGGAGGCGAGAAGCGCCTGTGTCTGCCGCAGATT
CTCAACTCGGTGCTGCGCGACTTCTCGCTGCAGCAGATCAACGCGGTGTGCGACGAGCTCCACATCTACTGCTCGCGCTGCACGGCCGAC
CAGCTGGAGATCCTCAAAGTCATGGGCATCCTGCCCTTCTCGGCGCCCTCGTGCGGGCTCATCACCAAGACGGACGCCGAGCGCCTGTGC
AACGCGCTGCTCTACGGCGGCGCCTACCCGCCGCCCTGCAAGAAGGAGCTGGCCGCCAGCCTGGCGCTGGGCCTGGAGCTCAGCGAGCGC
AGCGTCCGCGTGTACCACGAGTGCTTCGGCAAGTGTAAGGGGCTGCTGGTGCCCGAGCTCTACAGCAGCCCGAGCGCCGCCTGCATCCAG
TGCCTGGACTGCCGCCTCATGTACCCGCCGCACAAGTTCGTGGTGCACTCGCACAAGGCCCTGGAGAACCGGACCTGCCACTGGGGCTTC
GACTCGGCCAACTGGCGGGCCTACATCCTGCTGAGCCAGGATTACACGGGCAAGGAGGAGCAGGCGCGCCTCGGCCGCTGCCTGGACGAC
GTGAAGGAGAAATTCGACTATGGCAACAAGTACAAGCGGCGGGTGCCCCGGAGTGATCAGCAGCTGGACTGTGCCTTGGACCTAATGAGG
CGCCTGCCTCCCCAGCAAATCGAGAAAAACCTCAGCGACCTGATCGACCTGGTCCCCAGTCTATGTGAGGATCTCCTGTCTTCTGTTGAC
CAGCCACTGAAAATTGCCAGAGACAAGGTGGTGGGAAAGGATTACCTTTTGTGTGACTACAACAGAGATGGGGACTCCTATAGGTCACCA
TGGAGTAACAAGTATGACCCTCCCTTGGAGGATGGGGCCATGCCGTCAGCTCGGCTGAGAAAGCTGGAGGTGGAAGCCAACAATGCCTTT
GACCAGTATCGAGACCTGTATTTTGAAGGTGGCGTCTCATCTGTCTACCTCTGGGATCTGGATCATGGCTTTGCTGGAGTGATCCTCATA
AAGAAGGCTGGAGATGGATCAAAGAAGATCAAAGGCTGCTGGGATTCCATCCACGTGGTAGAAGTGCAGGAGAAATCCAGCGGTCGCACC
GCCCATTACAAGTTGACCTCCACGGTGATGCTGTGGCTGCAGACCAACAAATCTGGCTCTGGCACCATGAACCTCGGAGGCAGCCTTACC
AGACAGATGGAGAAGGATGAAACTGTGAGTGACTGCTCCCCACACATAGCCAACATCGGGCGCCTGGTAGAGGACATGGAAAATAAAATC
AGAAGTACGCTGAACGAGATCTACTTTGGAAAAACAAAGGATATCGTCAATGGGCTGAGGTCTGTGCAGACTTTTGCAGACAAATCAAAA
CAAGAAGCTCTGAAGAATGACCTGGTGGAGGCTTTGAAGAGAAAGCAGCAATGCTAAACCTCTGTTTCATGCTAACCAGACACGCCGTGC
ACTCGTTAGATTCCTTTCTTAGAAAACTCGTTTTCTGCTCCCTTCCCTCGTCCCTTCCCTCCCCGACAGGTCACATAACAGCTGCATCAT

>82083_82083_5_SKI-CAPZB_SKI_chr1_2161174_ENST00000378536_CAPZB_chr1_19746244_ENST00000433834_length(amino acids)=594AA_BP=321
MEAAAGGRGCFQPHPGLQKTLEQFHLSSMSSLGGPAAFSARWAQEAYKKESAKEAGAAAVPAPVPAATEPPPVLHLPAIQPPPPVLPGPF
FMPSDRSTERCETVLEGETISCFVVGGEKRLCLPQILNSVLRDFSLQQINAVCDELHIYCSRCTADQLEILKVMGILPFSAPSCGLITKT
DAERLCNALLYGGAYPPPCKKELAASLALGLELSERSVRVYHECFGKCKGLLVPELYSSPSAACIQCLDCRLMYPPHKFVVHSHKALENR
TCHWGFDSANWRAYILLSQDYTGKEEQARLGRCLDDVKEKFDYGNKYKRRVPRSDQQLDCALDLMRRLPPQQIEKNLSDLIDLVPSLCED
LLSSVDQPLKIARDKVVGKDYLLCDYNRDGDSYRSPWSNKYDPPLEDGAMPSARLRKLEVEANNAFDQYRDLYFEGGVSSVYLWDLDHGF
AGVILIKKAGDGSKKIKGCWDSIHVVEVQEKSSGRTAHYKLTSTVMLWLQTNKSGSGTMNLGGSLTRQMEKDETVSDCSPHIANIGRLVE

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Fusion Gene PPI Analysis for SKI-CAPZB


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SKI-CAPZB


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SKI-CAPZB


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource