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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SKIL-LEPREL1 (FusionGDB2 ID:82095)

Fusion Gene Summary for SKIL-LEPREL1

Fusion gene summary

Fusion gene information	Fusion gene name: SKIL-LEPREL1
	Fusion gene ID: 82095
		Hgene	Tgene
	Gene symbol	SKIL	LEPREL1
	Gene ID	6498	55214
	Gene name	SKI like proto-oncogene	prolyl 3-hydroxylase 2
	Synonyms	SNO\|SnoA\|SnoI\|SnoN	LEPREL1\|MCVD\|MLAT4
	Cytomap	3q26.2	3q28
	Type of gene	protein-coding	protein-coding
	Description	ski-like proteinSKI-like oncogeneski-related oncogene snoN	prolyl 3-hydroxylase 2leprecan-like 1myxoid liposarcoma-associated protein 4procollagen-proline 3-dioxygenase 2prolyl 3-hydroxylase 3
	Modification date	20200313	20200313
	UniProtAcc	.	.
	Ensembl transtripts involved in fusion gene	ENST00000259119, ENST00000413427, ENST00000426052, ENST00000458537, ENST00000490989,	ENST00000427335, ENST00000319332,
Fusion gene scores	* DoF score	7 X 5 X 6=210	5 X 3 X 5=75
	# samples	8	6
	** MAII score	log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SKIL [Title/Abstract] AND LEPREL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SKIL(170079217)-LEPREL1(189713231), # samples:2
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	LEPREL1	GO:0008285	negative regulation of cell proliferation	19436308
Tgene	LEPREL1	GO:0019511	peptidyl-proline hydroxylation	18487197
Tgene	LEPREL1	GO:0032963	collagen metabolic process	18487197

Fusion gene breakpoints across SKIL (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LEPREL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-2H-A9GR	SKIL	chr3	170079217	+	LEPREL1	chr3	189713231	-

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Fusion Gene ORF analysis for SKIL-LEPREL1

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000259119	ENST00000427335	SKIL	chr3	170079217	+	LEPREL1	chr3	189713231	-
5CDS-5UTR	ENST00000413427	ENST00000427335	SKIL	chr3	170079217	+	LEPREL1	chr3	189713231	-
5CDS-5UTR	ENST00000426052	ENST00000427335	SKIL	chr3	170079217	+	LEPREL1	chr3	189713231	-
5CDS-5UTR	ENST00000458537	ENST00000427335	SKIL	chr3	170079217	+	LEPREL1	chr3	189713231	-
In-frame	ENST00000259119	ENST00000319332	SKIL	chr3	170079217	+	LEPREL1	chr3	189713231	-
In-frame	ENST00000413427	ENST00000319332	SKIL	chr3	170079217	+	LEPREL1	chr3	189713231	-
In-frame	ENST00000426052	ENST00000319332	SKIL	chr3	170079217	+	LEPREL1	chr3	189713231	-
In-frame	ENST00000458537	ENST00000319332	SKIL	chr3	170079217	+	LEPREL1	chr3	189713231	-
intron-3CDS	ENST00000490989	ENST00000319332	SKIL	chr3	170079217	+	LEPREL1	chr3	189713231	-
intron-5UTR	ENST00000490989	ENST00000427335	SKIL	chr3	170079217	+	LEPREL1	chr3	189713231	-

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000259119	SKIL	chr3	170079217	+	ENST00000319332	LEPREL1	chr3	189713231	-	4600	1769	557	3415	952
ENST00000426052	SKIL	chr3	170079217	+	ENST00000319332	LEPREL1	chr3	189713231	-	4101	1270	181	2916	911
ENST00000413427	SKIL	chr3	170079217	+	ENST00000319332	LEPREL1	chr3	189713231	-	4638	1807	595	3453	952
ENST00000458537	SKIL	chr3	170079217	+	ENST00000319332	LEPREL1	chr3	189713231	-	4638	1807	595	3453	952

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000259119	ENST00000319332	SKIL	chr3	170079217	+	LEPREL1	chr3	189713231	-	0.000504008	0.999496
ENST00000426052	ENST00000319332	SKIL	chr3	170079217	+	LEPREL1	chr3	189713231	-	0.000709967	0.99929
ENST00000413427	ENST00000319332	SKIL	chr3	170079217	+	LEPREL1	chr3	189713231	-	0.000473652	0.9995264
ENST00000458537	ENST00000319332	SKIL	chr3	170079217	+	LEPREL1	chr3	189713231	-	0.000473652	0.9995264

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Fusion Genomic Features for SKIL-LEPREL1

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

1-p

p (fusion gene breakpoint)

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SKIL-LEPREL1

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:170079217/chr3:189713231)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

LEPREL1

chr3:170079217

chr3:189713231

ENST00000319332

557_671

160

709.0

Domain

Fe2OG dioxygenase

Tgene

LEPREL1

chr3:170079217

chr3:189713231

ENST00000319332

705_708

160

709.0

Motif

Prevents secretion from ER

Tgene

LEPREL1

chr3:170079217

chr3:189713231

ENST00000319332

210_243

160

709.0

Repeat

Note=TPR 3

Tgene

LEPREL1

chr3:170079217

chr3:189713231

ENST00000319332

306_339

160

709.0

Repeat

Note=TPR 4

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SKIL

chr3:170079217

chr3:189713231

ENST00000259119

536_684

366

685.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SKIL

chr3:170079217

chr3:189713231

ENST00000413427

536_684

366

639.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SKIL

chr3:170079217

chr3:189713231

ENST00000426052

536_684

346

665.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

SKIL

chr3:170079217

chr3:189713231

ENST00000458537

536_684

366

685.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

LEPREL1

chr3:170079217

chr3:189713231

ENST00000319332

93_99

160

709.0

Compositional bias

Note=Poly-Pro

Tgene

LEPREL1

chr3:170079217

chr3:189713231

ENST00000319332

148_181

160

709.0

Repeat

Note=TPR 2

Tgene

LEPREL1

chr3:170079217

chr3:189713231

ENST00000319332

44_77

160

709.0

Repeat

Note=TPR 1

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Fusion Gene Sequence for SKIL-LEPREL1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>82095_82095_1_SKIL-LEPREL1_SKIL_chr3_170079217_ENST00000259119_LEPREL1_chr3_189713231_ENST00000319332_length(transcript)=4600nt_BP=1769nt
GAGCGGGCGAGCGGCGACGGCGGCGGCGGCGGGCACAGATTAATTAAAAGAAGAATGAACTATAATCCTTGAAGATAACTGGGCAATTTT
TTAAGTCGGAGGCTGTTCTTACTGGTGTGAGGATTTACACACGTCTTCAGTTTTTCAGCACAGACCAGCAGACCATCATTTTTAGAGGAA
ATACTCCCTCTGCCCTCCTTTTTGGTTTCCTTGGTGGTAAAGATTAAATTTGGTTGCATCATTTTGACTTGTGTTTGAGTCTAGATTTTA
TGGCACAAGGAATGGCATAAACTTTTCATGTGTTTTGGTTAAAACAAACCAGACCATTGCATTGACCCTGGACATCTTTAATTGAGAAAT
TGGTAACTTTATTTTAATATGTATATCTGAAGAATTCAAGAAAACAAAGGCATCCTCAGAGGTGTGCCTCTTTTCTTTATTATTAGAGGC
AAAACGAACAATTTTATAGGATTTGTAGTGAAATTATACCAGATTATAAGGAGAACCAAAACTAAGTCGCAAAATTTATTAATTTAAGGG
GCTCTCGCTTTGAAAGTTTGAGAGTAAGTTACGATAGGCATTTGTATCCATTCATTACTTTCCTCTTTTCAAATAAGCAACTAAATAGAA
ATGCTAATCTCAGACTTAATTATTTAACAGAAGAGTGTACCATGGAAAACCTCCAGACAAATTTCTCCTTGGTTCAGGGCTCAACTAAAA
AACTGAATGGGATGGGAGATGATGGCAGCCCCCCAGCGAAAAAAATGATAACGGACATTCATGCAAATGGAAAAACGATAAACAAGGTGC
CAACAGTTAAGAAGGAACACTTGGATGACTATGGAGAAGCACCAGTGGAAACTGATGGAGAGCATGTTAAGCGAACCTGTACTTCTGTTC
CTGAAACTTTGCATTTAAATCCCAGTTTGAAACACACATTGGCACAATTCCATTTAAGTAGTCAGAGCTCGCTGGGTGGACCAGCAGCAT
TTTCTGCTCGGCATTCCCAAGAAAGCATGTCGCCTACTGTATTTCTGCCTCTTCCATCACCTCAGGTTCTTCCTGGCCCATTGCTCATCC
CTTCAGATAGCTCCACAGAACTCACTCAGACTGTGTTGGAAGGGGAATCTATTTCTTGTTTTCAAGTTGGAGGAGAAAAGAGACTCTGTT
TGCCCCAAGTCTTAAATTCTGTTCTCCGAGAATTTACACTCCAGCAAATAAATACAGTGTGTGATGAACTGTACATATATTGTTCAAGGT
GTACTTCAGACCAGCTTCATATCTTAAAGGTACTGGGCATACTTCCATTCAATGCCCCATCCTGTGGGCTGATTACATTAACTGATGCAC
AAAGATTATGTAATGCTTTATTGCGGCCACGAACTTTTCCTCAAAATGGTAGCGTACTTCCTGCTAAAAGCTCATTGGCCCAGTTAAAGG
AAACTGGCAGTGCCTTTGAAGTGGAGCATGAATGCCTAGGCAAATGTCAGGGTTTATTTGCACCCCAGTTTTATGTTCAGCCTGATGCTC
CGTGTATTCAATGTCTGGAGTGTTGTGGAATGTTTGCACCCCAGACGTTTGTGATGCATTCTCACAGATCACCTGACAAAAGAACTTGCC
ACTGGGGCTTTGAATCAGCTAAATGGCATTGCTATCTTCATGTGAACCAAAAATACTTAGGAACACCTGAAGAAAAGAAACTGAAGATAA
TTTTAGAAGAAATGAAGGAGAAGTTTAGCATGAGAAGTGGAAAGAGAAATCAATCCAAGCTTAACCAGCTCGAAAAAGCAGTGGAAGCAG
CTCACACATTTTTCGTGGCTAACCCTGAGCACATGGAAATGCAGCAGAACATTGAGAATTACAGGGCGACAGCTGGTGTTGAAGCATTGC
AGTTGGTAGACAGAGAAGCCAAGCCACACATGGAGAGTTACAATGCAGGAGTTAAACATTATGAGGCTGATGACTTTGAGATGGCTATCA
GGCACTTCGAACAAGCCTTAAGAGAATATTTCGTTGAAGATACAGAATGCCGGACCCTATGTGAGGGGCCTCAGAGATTTGAAGAATATG
AGTATTTAGGGTATAAGGCTGGTCTGTATGAAGCTATTGCAGATCACTACATGCAGGTGCTTGTTTGTCAGCATGAATGTGTGAGGGAAC
TTGCCACCCGCCCTGGCCGCCTCTCTCCCATCGAGAATTTTCTTCCTCTGCACTATGATTACCTACAGTTTGCCTACTATCGAGTTGGTG
AGTATGTGAAAGCCCTGGAGTGTGCCAAAGCCTATCTTCTATGCCATCCAGATGATGAGGATGTCCTAGACAATGTGGATTACTATGAGA
GTCTGCTGGATGATAGCATTGACCCGGCATCCATTGAGGCCAGAGAGGATTTAACAATGTTTGTGAAACGTCATAAGCTGGAGTCTGAGC
TGATAAAATCAGCTGCAGAAGGTCTGGGGTTTTCATACACTGAACCGAATTATTGGATCAGATATGGAGGACGACAGGATGAGAATCGGG
TCCCTTCAGGAGTGAACGTAGAGGGAGCAGAAGTTCATGGATTCTCAATGGGAAAAAAGCTATCACCCAAGATAGATCGAGACCTAAGAG
AAGGTGGTCCTCTACTCTATGAGAACATCACATTCGTCTACAACTCGGAGCAGCTGAACGGGACTCAGCGGGTTCTCCTGGATAACGTCC
TGTCGGAAGAACAGTGCCGGGAGCTCCACAGCGTGGCCAGTGGAATCATGCTTGTTGGTGATGGATACAGAGGAAAAACTTCACCCCATA
CACCCAATGAAAAGTTTGAAGGTGCAACTGTCCTGAAAGCACTCAAATCTGGTTATGAAGGTCGAGTCCCACTGAAGAGCGCTCGTCTGT
TTTATGACATCAGCGAAAAGGCTCGAAGGATTGTAGAATCTTATTTTATGCTGAACTCAACTCTGTATTTTTCCTATACACACATGGTCT
GCCGAACAGCCCTGTCTGGTCAGCAGGATAGAAGAAATGACCTCAGTCATCCCATCCATGCTGACAACTGTTTGTTGGATCCAGAGGCCA
ACGAATGCTGGAAGGAGCCTCCTGCTTACACATTTCGAGACTATAGTGCTCTCCTATATATGAATGATGACTTTGAAGGAGGAGAATTCA
TATTCACAGAGATGGATGCTAAGACTGTGACTGCCTCTATAAAACCAAAATGTGGGCGCATGATCAGCTTCTCATCTGGAGGAGAGAACC
CTCATGGGGTGAAGGCAGTCACCAAGGGAAAGAGGTGTGCTGTGGCTCTGTGGTTCACCTTGGACCCACTTTATAGAGAATTGGAGCGAA
TACAGGCTGATGAAGTGATTGCAATTCTGGATCAAGAACAGCAAGGGAAGCATGAACTGAATATCAACCCTAAAGATGAGCTATAAAAAT
GAGAAAGAATGTTCTATCAAATATTTATTTAAATTGTTAATCTTATGAGAACCTTTTTATTTTTGTACAGAGCCATGGTATAAATTAACA
GGTTAATGTCAGTCATCAGATCTTCCTTCTCTTCCTAAGGATGCTTGTGTTGCCTCAATCTATCAATCTATCTTTCTTGTTTTGGGTTGT
TTTCTCTCTCTCTCTCTCTCTCTCTCTTCTTAGAGACATGGTCTAACCATGTTGTCTAGGATATAGGGCAGTGGCTATTCACAGATGTGA
TGATAGCACACTGGAGCCTCAAACTCTTAGGCTCAGGCGATCCTTCAAGCCTCCCGGGGAGCTGGGACCACAGGCACGTGCCACCACACC
CAGCTCTCTTTCTTGGTTTTTCATCATTTCATGTATCTATCAAAGCCCAGTTCACCTCCTCCCCCAAACACACACACACACACACACACA
CACACACACACACACAATTAAGTTGCTGCAAATTCAAAAGCTTAGAGAGAATAAGCTTCTTGGTGGTGAAACTACAACTCTCACGTGTGC
TCCAGTTCTAAAATTAACCTGTGCCTGGTCTCTGAAGCCCTTTCTTGCTCTGTGCCTTTCAGCCACATCCTTAGGTGCTAACGGCCATGA
GCTCCGACTCTCCAAAGTGAGCTCCACTTTGGGTCTGAGGAGCCCCTGGCAGAGTCCACGCTGCCTCAGGTATCATGGGCGTAATGATCA
CCCAGGCTCCGGGAGATCTCATGGATGATTACTGTATGAGACAGAGGGGACTTCAGTCTTTCCAGGGCCTTGGTGGAATTTTTGGCTCTG
GTGTTTTCGCCAGACAATAAACTTACACTGGAAGCTTTGATTCACCCTCCACAGTACTCCAGAAAGGACTGTCCTATAAGTTGTACACTT
TAAAAGGTCATGTAGAGGTTGTAGTAGAATGGCTTTTCACCCTGGTGACTTTGGAAGAAACTCTTGAATACTGCCTGCATCCGGGCACCA
TGGCCAGGTTGCCTAGGAGTGGGGTCCACTGATGAAAAGAGGTGTTTTGTACTTACATAAGAAAAATAAATTTCTGATTGATTTTAACCG
TCATCTGCTTATATTTTGGGGGCCCCTCCTCATTGCTGCTATCCAGCACACAGATTTGTGCTTGTGTCTGATTTGTTTAATAAAGGGAGG

>82095_82095_1_SKIL-LEPREL1_SKIL_chr3_170079217_ENST00000259119_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=952AA_BP=404
MRVSYDRHLYPFITFLFSNKQLNRNANLRLNYLTEECTMENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKE
HLDDYGEAPVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDSST
ELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNA
LLRPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFES
AKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDRE
AKPHMESYNAGVKHYEADDFEMAIRHFEQALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPG
RLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAA
EGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQC
RELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALS
GQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKA

--------------------------------------------------------------
>82095_82095_2_SKIL-LEPREL1_SKIL_chr3_170079217_ENST00000413427_LEPREL1_chr3_189713231_ENST00000319332_length(transcript)=4638nt_BP=1807nt
GGTTTCAAATTGGCCCTTTGGCCTCTGGAGCAAATTCAAATGTAACTCTTCCCCAACCCCCCTTCTCTTCTTCCAGATTAATTAAAAGAA
GAATGAACTATAATCCTTGAAGATAACTGGGCAATTTTTTAAGTCGGAGGCTGTTCTTACTGGTGTGAGGATTTACACACGTCTTCAGTT
TTTCAGCACAGACCAGCAGACCATCATTTTTAGAGGAAATACTCCCTCTGCCCTCCTTTTTGGTTTCCTTGGTGGTAAAGATTAAATTTG
GTTGCATCATTTTGACTTGTGTTTGAGTCTAGATTTTATGGCACAAGGAATGGCATAAACTTTTCATGTGTTTTGGTTAAAACAAACCAG
ACCATTGCATTGACCCTGGACATCTTTAATTGAGAAATTGGTAACTTTATTTTAATATGTATATCTGAAGAATTCAAGAAAACAAAGGCA
TCCTCAGAGGTGTGCCTCTTTTCTTTATTATTAGAGGCAAAACGAACAATTTTATAGGATTTGTAGTGAAATTATACCAGATTATAAGGA
GAACCAAAACTAAGTCGCAAAATTTATTAATTTAAGGGGCTCTCGCTTTGAAAGTTTGAGAGTAAGTTACGATAGGCATTTGTATCCATT
CATTACTTTCCTCTTTTCAAATAAGCAACTAAATAGAAATGCTAATCTCAGACTTAATTATTTAACAGAAGAGTGTACCATGGAAAACCT
CCAGACAAATTTCTCCTTGGTTCAGGGCTCAACTAAAAAACTGAATGGGATGGGAGATGATGGCAGCCCCCCAGCGAAAAAAATGATAAC
GGACATTCATGCAAATGGAAAAACGATAAACAAGGTGCCAACAGTTAAGAAGGAACACTTGGATGACTATGGAGAAGCACCAGTGGAAAC
TGATGGAGAGCATGTTAAGCGAACCTGTACTTCTGTTCCTGAAACTTTGCATTTAAATCCCAGTTTGAAACACACATTGGCACAATTCCA
TTTAAGTAGTCAGAGCTCGCTGGGTGGACCAGCAGCATTTTCTGCTCGGCATTCCCAAGAAAGCATGTCGCCTACTGTATTTCTGCCTCT
TCCATCACCTCAGGTTCTTCCTGGCCCATTGCTCATCCCTTCAGATAGCTCCACAGAACTCACTCAGACTGTGTTGGAAGGGGAATCTAT
TTCTTGTTTTCAAGTTGGAGGAGAAAAGAGACTCTGTTTGCCCCAAGTCTTAAATTCTGTTCTCCGAGAATTTACACTCCAGCAAATAAA
TACAGTGTGTGATGAACTGTACATATATTGTTCAAGGTGTACTTCAGACCAGCTTCATATCTTAAAGGTACTGGGCATACTTCCATTCAA
TGCCCCATCCTGTGGGCTGATTACATTAACTGATGCACAAAGATTATGTAATGCTTTATTGCGGCCACGAACTTTTCCTCAAAATGGTAG
CGTACTTCCTGCTAAAAGCTCATTGGCCCAGTTAAAGGAAACTGGCAGTGCCTTTGAAGTGGAGCATGAATGCCTAGGCAAATGTCAGGG
TTTATTTGCACCCCAGTTTTATGTTCAGCCTGATGCTCCGTGTATTCAATGTCTGGAGTGTTGTGGAATGTTTGCACCCCAGACGTTTGT
GATGCATTCTCACAGATCACCTGACAAAAGAACTTGCCACTGGGGCTTTGAATCAGCTAAATGGCATTGCTATCTTCATGTGAACCAAAA
ATACTTAGGAACACCTGAAGAAAAGAAACTGAAGATAATTTTAGAAGAAATGAAGGAGAAGTTTAGCATGAGAAGTGGAAAGAGAAATCA
ATCCAAGCTTAACCAGCTCGAAAAAGCAGTGGAAGCAGCTCACACATTTTTCGTGGCTAACCCTGAGCACATGGAAATGCAGCAGAACAT
TGAGAATTACAGGGCGACAGCTGGTGTTGAAGCATTGCAGTTGGTAGACAGAGAAGCCAAGCCACACATGGAGAGTTACAATGCAGGAGT
TAAACATTATGAGGCTGATGACTTTGAGATGGCTATCAGGCACTTCGAACAAGCCTTAAGAGAATATTTCGTTGAAGATACAGAATGCCG
GACCCTATGTGAGGGGCCTCAGAGATTTGAAGAATATGAGTATTTAGGGTATAAGGCTGGTCTGTATGAAGCTATTGCAGATCACTACAT
GCAGGTGCTTGTTTGTCAGCATGAATGTGTGAGGGAACTTGCCACCCGCCCTGGCCGCCTCTCTCCCATCGAGAATTTTCTTCCTCTGCA
CTATGATTACCTACAGTTTGCCTACTATCGAGTTGGTGAGTATGTGAAAGCCCTGGAGTGTGCCAAAGCCTATCTTCTATGCCATCCAGA
TGATGAGGATGTCCTAGACAATGTGGATTACTATGAGAGTCTGCTGGATGATAGCATTGACCCGGCATCCATTGAGGCCAGAGAGGATTT
AACAATGTTTGTGAAACGTCATAAGCTGGAGTCTGAGCTGATAAAATCAGCTGCAGAAGGTCTGGGGTTTTCATACACTGAACCGAATTA
TTGGATCAGATATGGAGGACGACAGGATGAGAATCGGGTCCCTTCAGGAGTGAACGTAGAGGGAGCAGAAGTTCATGGATTCTCAATGGG
AAAAAAGCTATCACCCAAGATAGATCGAGACCTAAGAGAAGGTGGTCCTCTACTCTATGAGAACATCACATTCGTCTACAACTCGGAGCA
GCTGAACGGGACTCAGCGGGTTCTCCTGGATAACGTCCTGTCGGAAGAACAGTGCCGGGAGCTCCACAGCGTGGCCAGTGGAATCATGCT
TGTTGGTGATGGATACAGAGGAAAAACTTCACCCCATACACCCAATGAAAAGTTTGAAGGTGCAACTGTCCTGAAAGCACTCAAATCTGG
TTATGAAGGTCGAGTCCCACTGAAGAGCGCTCGTCTGTTTTATGACATCAGCGAAAAGGCTCGAAGGATTGTAGAATCTTATTTTATGCT
GAACTCAACTCTGTATTTTTCCTATACACACATGGTCTGCCGAACAGCCCTGTCTGGTCAGCAGGATAGAAGAAATGACCTCAGTCATCC
CATCCATGCTGACAACTGTTTGTTGGATCCAGAGGCCAACGAATGCTGGAAGGAGCCTCCTGCTTACACATTTCGAGACTATAGTGCTCT
CCTATATATGAATGATGACTTTGAAGGAGGAGAATTCATATTCACAGAGATGGATGCTAAGACTGTGACTGCCTCTATAAAACCAAAATG
TGGGCGCATGATCAGCTTCTCATCTGGAGGAGAGAACCCTCATGGGGTGAAGGCAGTCACCAAGGGAAAGAGGTGTGCTGTGGCTCTGTG
GTTCACCTTGGACCCACTTTATAGAGAATTGGAGCGAATACAGGCTGATGAAGTGATTGCAATTCTGGATCAAGAACAGCAAGGGAAGCA
TGAACTGAATATCAACCCTAAAGATGAGCTATAAAAATGAGAAAGAATGTTCTATCAAATATTTATTTAAATTGTTAATCTTATGAGAAC
CTTTTTATTTTTGTACAGAGCCATGGTATAAATTAACAGGTTAATGTCAGTCATCAGATCTTCCTTCTCTTCCTAAGGATGCTTGTGTTG
CCTCAATCTATCAATCTATCTTTCTTGTTTTGGGTTGTTTTCTCTCTCTCTCTCTCTCTCTCTCTTCTTAGAGACATGGTCTAACCATGT
TGTCTAGGATATAGGGCAGTGGCTATTCACAGATGTGATGATAGCACACTGGAGCCTCAAACTCTTAGGCTCAGGCGATCCTTCAAGCCT
CCCGGGGAGCTGGGACCACAGGCACGTGCCACCACACCCAGCTCTCTTTCTTGGTTTTTCATCATTTCATGTATCTATCAAAGCCCAGTT
CACCTCCTCCCCCAAACACACACACACACACACACACACACACACACACACACAATTAAGTTGCTGCAAATTCAAAAGCTTAGAGAGAAT
AAGCTTCTTGGTGGTGAAACTACAACTCTCACGTGTGCTCCAGTTCTAAAATTAACCTGTGCCTGGTCTCTGAAGCCCTTTCTTGCTCTG
TGCCTTTCAGCCACATCCTTAGGTGCTAACGGCCATGAGCTCCGACTCTCCAAAGTGAGCTCCACTTTGGGTCTGAGGAGCCCCTGGCAG
AGTCCACGCTGCCTCAGGTATCATGGGCGTAATGATCACCCAGGCTCCGGGAGATCTCATGGATGATTACTGTATGAGACAGAGGGGACT
TCAGTCTTTCCAGGGCCTTGGTGGAATTTTTGGCTCTGGTGTTTTCGCCAGACAATAAACTTACACTGGAAGCTTTGATTCACCCTCCAC
AGTACTCCAGAAAGGACTGTCCTATAAGTTGTACACTTTAAAAGGTCATGTAGAGGTTGTAGTAGAATGGCTTTTCACCCTGGTGACTTT
GGAAGAAACTCTTGAATACTGCCTGCATCCGGGCACCATGGCCAGGTTGCCTAGGAGTGGGGTCCACTGATGAAAAGAGGTGTTTTGTAC
TTACATAAGAAAAATAAATTTCTGATTGATTTTAACCGTCATCTGCTTATATTTTGGGGGCCCCTCCTCATTGCTGCTATCCAGCACACA

>82095_82095_2_SKIL-LEPREL1_SKIL_chr3_170079217_ENST00000413427_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=952AA_BP=404
MRVSYDRHLYPFITFLFSNKQLNRNANLRLNYLTEECTMENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKE
HLDDYGEAPVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDSST
ELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNA
LLRPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFES
AKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDRE
AKPHMESYNAGVKHYEADDFEMAIRHFEQALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPG
RLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAA
EGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQC
RELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALS
GQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKA

--------------------------------------------------------------
>82095_82095_3_SKIL-LEPREL1_SKIL_chr3_170079217_ENST00000426052_LEPREL1_chr3_189713231_ENST00000319332_length(transcript)=4101nt_BP=1270nt
GAGCGGCGACGGCGGCGGCGGCGGGCACAGATTAATTAAAAGAAGAATGAACTATAATCCTTGAAGATAACTGGGCAATTTTTTAAGTCG
GAGGCTGTTCTTACTGGTGTGAGGATTTACACACGTCTTCAGTTTTTCAGCACAGACCAGCAGACCATCATTTTTAGAGGAAATACTCCC
TCTGCCCTCCTTTTTGGTTTCCTTGGTGGGCTCAACTAAAAAACTGAATGGGATGGGAGATGATGGCAGCCCCCCAGCGAAAAAAATGAT
AACGGACATTCATGCAAATGGAAAAACGATAAACAAGGTGCCAACAGTTAAGAAGGAACACTTGGATGACTATGGAGAAGCACCAGTGGA
AACTGATGGAGAGCATGTTAAGCGAACCTGTACTTCTGTTCCTGAAACTTTGCATTTAAATCCCAGTTTGAAACACACATTGGCACAATT
CCATTTAAGTAGTCAGAGCTCGCTGGGTGGACCAGCAGCATTTTCTGCTCGGCATTCCCAAGAAAGCATGTCGCCTACTGTATTTCTGCC
TCTTCCATCACCTCAGGTTCTTCCTGGCCCATTGCTCATCCCTTCAGATAGCTCCACAGAACTCACTCAGACTGTGTTGGAAGGGGAATC
TATTTCTTGTTTTCAAGTTGGAGGAGAAAAGAGACTCTGTTTGCCCCAAGTCTTAAATTCTGTTCTCCGAGAATTTACACTCCAGCAAAT
AAATACAGTGTGTGATGAACTGTACATATATTGTTCAAGGTGTACTTCAGACCAGCTTCATATCTTAAAGGTACTGGGCATACTTCCATT
CAATGCCCCATCCTGTGGGCTGATTACATTAACTGATGCACAAAGATTATGTAATGCTTTATTGCGGCCACGAACTTTTCCTCAAAATGG
TAGCGTACTTCCTGCTAAAAGCTCATTGGCCCAGTTAAAGGAAACTGGCAGTGCCTTTGAAGTGGAGCATGAATGCCTAGGCAAATGTCA
GGGTTTATTTGCACCCCAGTTTTATGTTCAGCCTGATGCTCCGTGTATTCAATGTCTGGAGTGTTGTGGAATGTTTGCACCCCAGACGTT
TGTGATGCATTCTCACAGATCACCTGACAAAAGAACTTGCCACTGGGGCTTTGAATCAGCTAAATGGCATTGCTATCTTCATGTGAACCA
AAAATACTTAGGAACACCTGAAGAAAAGAAACTGAAGATAATTTTAGAAGAAATGAAGGAGAAGTTTAGCATGAGAAGTGGAAAGAGAAA
TCAATCCAAGCTTAACCAGCTCGAAAAAGCAGTGGAAGCAGCTCACACATTTTTCGTGGCTAACCCTGAGCACATGGAAATGCAGCAGAA
CATTGAGAATTACAGGGCGACAGCTGGTGTTGAAGCATTGCAGTTGGTAGACAGAGAAGCCAAGCCACACATGGAGAGTTACAATGCAGG
AGTTAAACATTATGAGGCTGATGACTTTGAGATGGCTATCAGGCACTTCGAACAAGCCTTAAGAGAATATTTCGTTGAAGATACAGAATG
CCGGACCCTATGTGAGGGGCCTCAGAGATTTGAAGAATATGAGTATTTAGGGTATAAGGCTGGTCTGTATGAAGCTATTGCAGATCACTA
CATGCAGGTGCTTGTTTGTCAGCATGAATGTGTGAGGGAACTTGCCACCCGCCCTGGCCGCCTCTCTCCCATCGAGAATTTTCTTCCTCT
GCACTATGATTACCTACAGTTTGCCTACTATCGAGTTGGTGAGTATGTGAAAGCCCTGGAGTGTGCCAAAGCCTATCTTCTATGCCATCC
AGATGATGAGGATGTCCTAGACAATGTGGATTACTATGAGAGTCTGCTGGATGATAGCATTGACCCGGCATCCATTGAGGCCAGAGAGGA
TTTAACAATGTTTGTGAAACGTCATAAGCTGGAGTCTGAGCTGATAAAATCAGCTGCAGAAGGTCTGGGGTTTTCATACACTGAACCGAA
TTATTGGATCAGATATGGAGGACGACAGGATGAGAATCGGGTCCCTTCAGGAGTGAACGTAGAGGGAGCAGAAGTTCATGGATTCTCAAT
GGGAAAAAAGCTATCACCCAAGATAGATCGAGACCTAAGAGAAGGTGGTCCTCTACTCTATGAGAACATCACATTCGTCTACAACTCGGA
GCAGCTGAACGGGACTCAGCGGGTTCTCCTGGATAACGTCCTGTCGGAAGAACAGTGCCGGGAGCTCCACAGCGTGGCCAGTGGAATCAT
GCTTGTTGGTGATGGATACAGAGGAAAAACTTCACCCCATACACCCAATGAAAAGTTTGAAGGTGCAACTGTCCTGAAAGCACTCAAATC
TGGTTATGAAGGTCGAGTCCCACTGAAGAGCGCTCGTCTGTTTTATGACATCAGCGAAAAGGCTCGAAGGATTGTAGAATCTTATTTTAT
GCTGAACTCAACTCTGTATTTTTCCTATACACACATGGTCTGCCGAACAGCCCTGTCTGGTCAGCAGGATAGAAGAAATGACCTCAGTCA
TCCCATCCATGCTGACAACTGTTTGTTGGATCCAGAGGCCAACGAATGCTGGAAGGAGCCTCCTGCTTACACATTTCGAGACTATAGTGC
TCTCCTATATATGAATGATGACTTTGAAGGAGGAGAATTCATATTCACAGAGATGGATGCTAAGACTGTGACTGCCTCTATAAAACCAAA
ATGTGGGCGCATGATCAGCTTCTCATCTGGAGGAGAGAACCCTCATGGGGTGAAGGCAGTCACCAAGGGAAAGAGGTGTGCTGTGGCTCT
GTGGTTCACCTTGGACCCACTTTATAGAGAATTGGAGCGAATACAGGCTGATGAAGTGATTGCAATTCTGGATCAAGAACAGCAAGGGAA
GCATGAACTGAATATCAACCCTAAAGATGAGCTATAAAAATGAGAAAGAATGTTCTATCAAATATTTATTTAAATTGTTAATCTTATGAG
AACCTTTTTATTTTTGTACAGAGCCATGGTATAAATTAACAGGTTAATGTCAGTCATCAGATCTTCCTTCTCTTCCTAAGGATGCTTGTG
TTGCCTCAATCTATCAATCTATCTTTCTTGTTTTGGGTTGTTTTCTCTCTCTCTCTCTCTCTCTCTCTTCTTAGAGACATGGTCTAACCA
TGTTGTCTAGGATATAGGGCAGTGGCTATTCACAGATGTGATGATAGCACACTGGAGCCTCAAACTCTTAGGCTCAGGCGATCCTTCAAG
CCTCCCGGGGAGCTGGGACCACAGGCACGTGCCACCACACCCAGCTCTCTTTCTTGGTTTTTCATCATTTCATGTATCTATCAAAGCCCA
GTTCACCTCCTCCCCCAAACACACACACACACACACACACACACACACACACACACAATTAAGTTGCTGCAAATTCAAAAGCTTAGAGAG
AATAAGCTTCTTGGTGGTGAAACTACAACTCTCACGTGTGCTCCAGTTCTAAAATTAACCTGTGCCTGGTCTCTGAAGCCCTTTCTTGCT
CTGTGCCTTTCAGCCACATCCTTAGGTGCTAACGGCCATGAGCTCCGACTCTCCAAAGTGAGCTCCACTTTGGGTCTGAGGAGCCCCTGG
CAGAGTCCACGCTGCCTCAGGTATCATGGGCGTAATGATCACCCAGGCTCCGGGAGATCTCATGGATGATTACTGTATGAGACAGAGGGG
ACTTCAGTCTTTCCAGGGCCTTGGTGGAATTTTTGGCTCTGGTGTTTTCGCCAGACAATAAACTTACACTGGAAGCTTTGATTCACCCTC
CACAGTACTCCAGAAAGGACTGTCCTATAAGTTGTACACTTTAAAAGGTCATGTAGAGGTTGTAGTAGAATGGCTTTTCACCCTGGTGAC
TTTGGAAGAAACTCTTGAATACTGCCTGCATCCGGGCACCATGGCCAGGTTGCCTAGGAGTGGGGTCCACTGATGAAAAGAGGTGTTTTG
TACTTACATAAGAAAAATAAATTTCTGATTGATTTTAACCGTCATCTGCTTATATTTTGGGGGCCCCTCCTCATTGCTGCTATCCAGCAC

>82095_82095_3_SKIL-LEPREL1_SKIL_chr3_170079217_ENST00000426052_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=911AA_BP=363
MPSFLVSLVGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKEHLDDYGEAPVETDGEHVKRTCTSVPETLHLNPSLKHTLAQF
HLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDSSTELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQI
NTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNALLRPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQ
GLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFESAKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRN
QSKLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDREAKPHMESYNAGVKHYEADDFEMAIRHFEQALREYFVEDTEC
RTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPGRLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYLLCHP
DDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAAEGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAEVHGFSM
GKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQCRELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATVLKALKS
GYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALSGQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSA
LLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKAVTKGKRCAVALWFTLDPLYRELERIQADEVIAILDQEQQGK

--------------------------------------------------------------
>82095_82095_4_SKIL-LEPREL1_SKIL_chr3_170079217_ENST00000458537_LEPREL1_chr3_189713231_ENST00000319332_length(transcript)=4638nt_BP=1807nt
GGTTTCAAATTGGCCCTTTGGCCTCTGGAGCAAATTCAAATGTAACTCTTCCCCAACCCCCCTTCTCTTCTTCCAGATTAATTAAAAGAA
GAATGAACTATAATCCTTGAAGATAACTGGGCAATTTTTTAAGTCGGAGGCTGTTCTTACTGGTGTGAGGATTTACACACGTCTTCAGTT
TTTCAGCACAGACCAGCAGACCATCATTTTTAGAGGAAATACTCCCTCTGCCCTCCTTTTTGGTTTCCTTGGTGGTAAAGATTAAATTTG
GTTGCATCATTTTGACTTGTGTTTGAGTCTAGATTTTATGGCACAAGGAATGGCATAAACTTTTCATGTGTTTTGGTTAAAACAAACCAG
ACCATTGCATTGACCCTGGACATCTTTAATTGAGAAATTGGTAACTTTATTTTAATATGTATATCTGAAGAATTCAAGAAAACAAAGGCA
TCCTCAGAGGTGTGCCTCTTTTCTTTATTATTAGAGGCAAAACGAACAATTTTATAGGATTTGTAGTGAAATTATACCAGATTATAAGGA
GAACCAAAACTAAGTCGCAAAATTTATTAATTTAAGGGGCTCTCGCTTTGAAAGTTTGAGAGTAAGTTACGATAGGCATTTGTATCCATT
CATTACTTTCCTCTTTTCAAATAAGCAACTAAATAGAAATGCTAATCTCAGACTTAATTATTTAACAGAAGAGTGTACCATGGAAAACCT
CCAGACAAATTTCTCCTTGGTTCAGGGCTCAACTAAAAAACTGAATGGGATGGGAGATGATGGCAGCCCCCCAGCGAAAAAAATGATAAC
GGACATTCATGCAAATGGAAAAACGATAAACAAGGTGCCAACAGTTAAGAAGGAACACTTGGATGACTATGGAGAAGCACCAGTGGAAAC
TGATGGAGAGCATGTTAAGCGAACCTGTACTTCTGTTCCTGAAACTTTGCATTTAAATCCCAGTTTGAAACACACATTGGCACAATTCCA
TTTAAGTAGTCAGAGCTCGCTGGGTGGACCAGCAGCATTTTCTGCTCGGCATTCCCAAGAAAGCATGTCGCCTACTGTATTTCTGCCTCT
TCCATCACCTCAGGTTCTTCCTGGCCCATTGCTCATCCCTTCAGATAGCTCCACAGAACTCACTCAGACTGTGTTGGAAGGGGAATCTAT
TTCTTGTTTTCAAGTTGGAGGAGAAAAGAGACTCTGTTTGCCCCAAGTCTTAAATTCTGTTCTCCGAGAATTTACACTCCAGCAAATAAA
TACAGTGTGTGATGAACTGTACATATATTGTTCAAGGTGTACTTCAGACCAGCTTCATATCTTAAAGGTACTGGGCATACTTCCATTCAA
TGCCCCATCCTGTGGGCTGATTACATTAACTGATGCACAAAGATTATGTAATGCTTTATTGCGGCCACGAACTTTTCCTCAAAATGGTAG
CGTACTTCCTGCTAAAAGCTCATTGGCCCAGTTAAAGGAAACTGGCAGTGCCTTTGAAGTGGAGCATGAATGCCTAGGCAAATGTCAGGG
TTTATTTGCACCCCAGTTTTATGTTCAGCCTGATGCTCCGTGTATTCAATGTCTGGAGTGTTGTGGAATGTTTGCACCCCAGACGTTTGT
GATGCATTCTCACAGATCACCTGACAAAAGAACTTGCCACTGGGGCTTTGAATCAGCTAAATGGCATTGCTATCTTCATGTGAACCAAAA
ATACTTAGGAACACCTGAAGAAAAGAAACTGAAGATAATTTTAGAAGAAATGAAGGAGAAGTTTAGCATGAGAAGTGGAAAGAGAAATCA
ATCCAAGCTTAACCAGCTCGAAAAAGCAGTGGAAGCAGCTCACACATTTTTCGTGGCTAACCCTGAGCACATGGAAATGCAGCAGAACAT
TGAGAATTACAGGGCGACAGCTGGTGTTGAAGCATTGCAGTTGGTAGACAGAGAAGCCAAGCCACACATGGAGAGTTACAATGCAGGAGT
TAAACATTATGAGGCTGATGACTTTGAGATGGCTATCAGGCACTTCGAACAAGCCTTAAGAGAATATTTCGTTGAAGATACAGAATGCCG
GACCCTATGTGAGGGGCCTCAGAGATTTGAAGAATATGAGTATTTAGGGTATAAGGCTGGTCTGTATGAAGCTATTGCAGATCACTACAT
GCAGGTGCTTGTTTGTCAGCATGAATGTGTGAGGGAACTTGCCACCCGCCCTGGCCGCCTCTCTCCCATCGAGAATTTTCTTCCTCTGCA
CTATGATTACCTACAGTTTGCCTACTATCGAGTTGGTGAGTATGTGAAAGCCCTGGAGTGTGCCAAAGCCTATCTTCTATGCCATCCAGA
TGATGAGGATGTCCTAGACAATGTGGATTACTATGAGAGTCTGCTGGATGATAGCATTGACCCGGCATCCATTGAGGCCAGAGAGGATTT
AACAATGTTTGTGAAACGTCATAAGCTGGAGTCTGAGCTGATAAAATCAGCTGCAGAAGGTCTGGGGTTTTCATACACTGAACCGAATTA
TTGGATCAGATATGGAGGACGACAGGATGAGAATCGGGTCCCTTCAGGAGTGAACGTAGAGGGAGCAGAAGTTCATGGATTCTCAATGGG
AAAAAAGCTATCACCCAAGATAGATCGAGACCTAAGAGAAGGTGGTCCTCTACTCTATGAGAACATCACATTCGTCTACAACTCGGAGCA
GCTGAACGGGACTCAGCGGGTTCTCCTGGATAACGTCCTGTCGGAAGAACAGTGCCGGGAGCTCCACAGCGTGGCCAGTGGAATCATGCT
TGTTGGTGATGGATACAGAGGAAAAACTTCACCCCATACACCCAATGAAAAGTTTGAAGGTGCAACTGTCCTGAAAGCACTCAAATCTGG
TTATGAAGGTCGAGTCCCACTGAAGAGCGCTCGTCTGTTTTATGACATCAGCGAAAAGGCTCGAAGGATTGTAGAATCTTATTTTATGCT
GAACTCAACTCTGTATTTTTCCTATACACACATGGTCTGCCGAACAGCCCTGTCTGGTCAGCAGGATAGAAGAAATGACCTCAGTCATCC
CATCCATGCTGACAACTGTTTGTTGGATCCAGAGGCCAACGAATGCTGGAAGGAGCCTCCTGCTTACACATTTCGAGACTATAGTGCTCT
CCTATATATGAATGATGACTTTGAAGGAGGAGAATTCATATTCACAGAGATGGATGCTAAGACTGTGACTGCCTCTATAAAACCAAAATG
TGGGCGCATGATCAGCTTCTCATCTGGAGGAGAGAACCCTCATGGGGTGAAGGCAGTCACCAAGGGAAAGAGGTGTGCTGTGGCTCTGTG
GTTCACCTTGGACCCACTTTATAGAGAATTGGAGCGAATACAGGCTGATGAAGTGATTGCAATTCTGGATCAAGAACAGCAAGGGAAGCA
TGAACTGAATATCAACCCTAAAGATGAGCTATAAAAATGAGAAAGAATGTTCTATCAAATATTTATTTAAATTGTTAATCTTATGAGAAC
CTTTTTATTTTTGTACAGAGCCATGGTATAAATTAACAGGTTAATGTCAGTCATCAGATCTTCCTTCTCTTCCTAAGGATGCTTGTGTTG
CCTCAATCTATCAATCTATCTTTCTTGTTTTGGGTTGTTTTCTCTCTCTCTCTCTCTCTCTCTCTTCTTAGAGACATGGTCTAACCATGT
TGTCTAGGATATAGGGCAGTGGCTATTCACAGATGTGATGATAGCACACTGGAGCCTCAAACTCTTAGGCTCAGGCGATCCTTCAAGCCT
CCCGGGGAGCTGGGACCACAGGCACGTGCCACCACACCCAGCTCTCTTTCTTGGTTTTTCATCATTTCATGTATCTATCAAAGCCCAGTT
CACCTCCTCCCCCAAACACACACACACACACACACACACACACACACACACACAATTAAGTTGCTGCAAATTCAAAAGCTTAGAGAGAAT
AAGCTTCTTGGTGGTGAAACTACAACTCTCACGTGTGCTCCAGTTCTAAAATTAACCTGTGCCTGGTCTCTGAAGCCCTTTCTTGCTCTG
TGCCTTTCAGCCACATCCTTAGGTGCTAACGGCCATGAGCTCCGACTCTCCAAAGTGAGCTCCACTTTGGGTCTGAGGAGCCCCTGGCAG
AGTCCACGCTGCCTCAGGTATCATGGGCGTAATGATCACCCAGGCTCCGGGAGATCTCATGGATGATTACTGTATGAGACAGAGGGGACT
TCAGTCTTTCCAGGGCCTTGGTGGAATTTTTGGCTCTGGTGTTTTCGCCAGACAATAAACTTACACTGGAAGCTTTGATTCACCCTCCAC
AGTACTCCAGAAAGGACTGTCCTATAAGTTGTACACTTTAAAAGGTCATGTAGAGGTTGTAGTAGAATGGCTTTTCACCCTGGTGACTTT
GGAAGAAACTCTTGAATACTGCCTGCATCCGGGCACCATGGCCAGGTTGCCTAGGAGTGGGGTCCACTGATGAAAAGAGGTGTTTTGTAC
TTACATAAGAAAAATAAATTTCTGATTGATTTTAACCGTCATCTGCTTATATTTTGGGGGCCCCTCCTCATTGCTGCTATCCAGCACACA

>82095_82095_4_SKIL-LEPREL1_SKIL_chr3_170079217_ENST00000458537_LEPREL1_chr3_189713231_ENST00000319332_length(amino acids)=952AA_BP=404
MRVSYDRHLYPFITFLFSNKQLNRNANLRLNYLTEECTMENLQTNFSLVQGSTKKLNGMGDDGSPPAKKMITDIHANGKTINKVPTVKKE
HLDDYGEAPVETDGEHVKRTCTSVPETLHLNPSLKHTLAQFHLSSQSSLGGPAAFSARHSQESMSPTVFLPLPSPQVLPGPLLIPSDSST
ELTQTVLEGESISCFQVGGEKRLCLPQVLNSVLREFTLQQINTVCDELYIYCSRCTSDQLHILKVLGILPFNAPSCGLITLTDAQRLCNA
LLRPRTFPQNGSVLPAKSSLAQLKETGSAFEVEHECLGKCQGLFAPQFYVQPDAPCIQCLECCGMFAPQTFVMHSHRSPDKRTCHWGFES
AKWHCYLHVNQKYLGTPEEKKLKIILEEMKEKFSMRSGKRNQSKLNQLEKAVEAAHTFFVANPEHMEMQQNIENYRATAGVEALQLVDRE
AKPHMESYNAGVKHYEADDFEMAIRHFEQALREYFVEDTECRTLCEGPQRFEEYEYLGYKAGLYEAIADHYMQVLVCQHECVRELATRPG
RLSPIENFLPLHYDYLQFAYYRVGEYVKALECAKAYLLCHPDDEDVLDNVDYYESLLDDSIDPASIEAREDLTMFVKRHKLESELIKSAA
EGLGFSYTEPNYWIRYGGRQDENRVPSGVNVEGAEVHGFSMGKKLSPKIDRDLREGGPLLYENITFVYNSEQLNGTQRVLLDNVLSEEQC
RELHSVASGIMLVGDGYRGKTSPHTPNEKFEGATVLKALKSGYEGRVPLKSARLFYDISEKARRIVESYFMLNSTLYFSYTHMVCRTALS
GQQDRRNDLSHPIHADNCLLDPEANECWKEPPAYTFRDYSALLYMNDDFEGGEFIFTEMDAKTVTASIKPKCGRMISFSSGGENPHGVKA

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for SKIL-LEPREL1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SKIL-LEPREL1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

Top

Related Diseases for SKIL-LEPREL1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source