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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:SKIV2L2-IGF2R (FusionGDB2 ID:82111)

Fusion Gene Summary for SKIV2L2-IGF2R

Fusion gene summary

Fusion gene information	Fusion gene name: SKIV2L2-IGF2R
	Fusion gene ID: 82111
		Hgene	Tgene
	Gene symbol	SKIV2L2	IGF2R
	Gene ID	23517	3482
	Gene name	Mtr4 exosome RNA helicase	insulin like growth factor 2 receptor
	Synonyms	Dob1\|KIAA0052\|Mtr4\|SKIV2L2\|fSAP118	CD222\|CI-M6PR\|CIMPR\|M6P-R\|M6P/IGF2R\|MPR 300\|MPR1\|MPR300\|MPRI
	Cytomap	5q11.2	6q25.3
	Type of gene	protein-coding	protein-coding
	Description	exosome RNA helicase MTR4ATP-dependent RNA helicase DOB1ATP-dependent RNA helicase SKIV2L2ATP-dependent helicase SKIV2L2Ski2 like RNA helicase 2TRAMP-like complex helicasefunctional spliceosome-associated protein 118superkiller viralicidic activity	cation-independent mannose-6-phosphate receptor300 kDa mannose 6-phosphate receptorCI Man-6-P receptorIGF-II receptorM6P/IGF2 receptorinsulin-like growth factor II receptor
	Modification date	20200313	20200315
	UniProtAcc	.	P11717
	Ensembl transtripts involved in fusion gene	ENST00000504388, ENST00000230640, ENST00000545714,	ENST00000356956, ENST00000475584,
Fusion gene scores	* DoF score	34 X 12 X 8=3264	3 X 3 X 3=27
	# samples	15	3
	** MAII score	log2(15/3264*10)=-4.44360665147561 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: SKIV2L2 [Title/Abstract] AND IGF2R [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	SKIV2L2(54603975)-IGF2R(160412216), # samples:2
Anticipated loss of major functional domain due to fusion event.	SKIV2L2-IGF2R seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. SKIV2L2-IGF2R seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SKIV2L2	GO:0006401	RNA catabolic process	29906447

Fusion gene breakpoints across SKIV2L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across IGF2R (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-02-2486-01A	SKIV2L2	chr5	54603975	+	IGF2R	chr6	160412216	+

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Fusion Gene ORF analysis for SKIV2L2-IGF2R

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
3UTR-3CDS	ENST00000504388	ENST00000356956	SKIV2L2	chr5	54603975	+	IGF2R	chr6	160412216	+
3UTR-intron	ENST00000504388	ENST00000475584	SKIV2L2	chr5	54603975	+	IGF2R	chr6	160412216	+
5CDS-intron	ENST00000230640	ENST00000475584	SKIV2L2	chr5	54603975	+	IGF2R	chr6	160412216	+
5CDS-intron	ENST00000545714	ENST00000475584	SKIV2L2	chr5	54603975	+	IGF2R	chr6	160412216	+
Frame-shift	ENST00000545714	ENST00000356956	SKIV2L2	chr5	54603975	+	IGF2R	chr6	160412216	+
In-frame	ENST00000230640	ENST00000356956	SKIV2L2	chr5	54603975	+	IGF2R	chr6	160412216	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

Seq length
(transcript)

BP loci
(transcript)

Predicted start
(transcript)

Predicted stop
(transcript)

Seq length
(amino acids)

ENST00000230640

SKIV2L2

chr5

54603975

ENST00000356956

IGF2R

chr6

160412216

9182

388

233

7714

2493

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000230640	ENST00000356956	SKIV2L2	chr5	54603975	+	IGF2R	chr6	160412216	+	0.000310443	0.9996896

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Fusion Genomic Features for SKIV2L2-IGF2R

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
SKIV2L2	chr5	54603975	+	IGF2R	chr6	160412215	+	4.98E-05	0.9999502
SKIV2L2	chr5	54603975	+	IGF2R	chr6	160412215	+	4.98E-05	0.9999502

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SKIV2L2-IGF2R

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:54603975/chr6:160412216)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	IGF2R P11717
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.	FUNCTION: Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:2963003, PubMed:18817523). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:2963003, PubMed:18817523). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005). {ECO:0000269\|PubMed:10900005, ECO:0000269\|PubMed:18046459, ECO:0000269\|PubMed:18817523, ECO:0000269\|PubMed:2963003}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

1082_1219

2492.0

Domain

MRH 8

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

1225_1363

2492.0

Domain

MRH 9

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

1367_1508

2492.0

Domain

MRH 10

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

1514_1648

2492.0

Domain

MRH 11

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

1650_1797

2492.0

Domain

MRH 12

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

172_320

2492.0

Domain

MRH 2

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

1802_1989

2492.0

Domain

Fibronectin type-II

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

1992_2127

2492.0

Domain

MRH 14

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

2135_2280

2492.0

Domain

MRH 15

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

326_468

2492.0

Domain

MRH 3

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

473_619

2492.0

Domain

MRH 4

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

47_163

2492.0

Domain

MRH 1

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

625_762

2492.0

Domain

MRH 5

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

765_924

2492.0

Domain

MRH 6

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

932_1079

2492.0

Domain

MRH 7

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

2328_2491

2492.0

Topological domain

Cytoplasmic

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

2305_2327

2492.0

Transmembrane

Helical

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SKIV2L2

chr5:54603975

chr6:160412216

ENST00000230640

148_304

1043.0

Domain

Helicase ATP-binding

Hgene

SKIV2L2

chr5:54603975

chr6:160412216

ENST00000230640

405_577

1043.0

Domain

Helicase C-terminal

Hgene

SKIV2L2

chr5:54603975

chr6:160412216

ENST00000230640

252_255

1043.0

Motif

Note=DEIH box

Hgene

SKIV2L2

chr5:54603975

chr6:160412216

ENST00000230640

161_168

1043.0

Nucleotide binding

ATP

Tgene

IGF2R

chr5:54603975

chr6:160412216

ENST00000356956

41_2304

2492.0

Topological domain

Lumenal

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Fusion Gene Sequence for SKIV2L2-IGF2R

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>82111_82111_1_SKIV2L2-IGF2R_SKIV2L2_chr5_54603975_ENST00000230640_IGF2R_chr6_160412216_ENST00000356956_length(transcript)=9182nt_BP=388nt
GCTGCCTGCCACACGCCAGGCGCCACGCGCCGCCCTCGCTCTTTATCCACTGAGCAGCTTATCCACTTTAGGTCGGAAAGGAAAGGAAAG
AAAAGCAGGAAAAAAAAAAAAAGTCAGGGGAACATTTTTGTCGGCTGCGCGACTCGACTACTTTTGTCTCCTGCGGGCCACTGTTGAGCC
TTCACGAGACGTCACTGTCTTCGGTCGCGGGGCATCGTGGGTAGGAGGGAGATTTGCTCTCACTGCTCCCAAAAATGGCGGACGCATTCG
GAGATGAGCTGTTCAGCGTGTTCGAGGGCGACTCGACCACTGCGGCGGGAACCAAAAAAGACAAGGAAAAGGACAAGGGGAAATGGAAGG
GGCCTCCAGGGTCTGCAGACAAGGCAGGTTATACATGGGAAGCTGTTGATACCAAAAATAATGTACTTTATAAAATCAACATCTGTGGAA
GTGTGGATATTGTCCAGTGCGGGCCATCAAGTGCTGTTTGTATGCACGACTTGAAGACACGCACTTATCATTCAGTGGGTGACTCTGTTT
TGAGAAGTGCAACCAGATCTCTCCTGGAATTCAACACAACAGTGAGCTGTGACCAGCAAGGCACAAATCACAGAGTCCAGAGCAGCATTG
CCTTCCTGTGTGGGAAAACCCTGGGAACTCCTGAATTTGTAACTGCAACAGAATGTGTGCACTACTTTGAGTGGAGGACCACTGCAGCCT
GCAAGAAAGACATATTTAAAGCAAATAAGGAGGTGCCATGCTATGTGTTTGATGAAGAGTTGAGGAAGCATGATCTCAATCCTCTGATCA
AGCTTAGTGGTGCCTACTTGGTGGATGACTCCGATCCGGACACTTCTCTATTCATCAATGTTTGTAGAGACATAGACACACTACGAGACC
CAGGTTCACAGCTGCGGGCCTGTCCCCCCGGCACTGCCGCCTGCCTGGTAAGAGGACACCAGGCGTTTGATGTTGGCCAGCCCCGGGACG
GACTGAAGCTGGTGCGCAAGGACAGGCTTGTCCTGAGTTACGTGAGGGAAGAGGCAGGAAAGCTAGACTTTTGTGATGGTCACAGCCCTG
CGGTGACTATTACATTTGTTTGCCCGTCGGAGCGGAGAGAGGGCACCATTCCCAAACTCACAGCTAAATCCAACTGCCGCTATGAAATTG
AGTGGATTACTGAGTATGCCTGCCACAGAGATTACCTGGAAAGTAAAACTTGTTCTCTGAGCGGCGAGCAGCAGGATGTCTCCATAGACC
TCACACCACTTGCCCAGAGCGGAGGTTCATCCTATATTTCAGATGGAAAAGAATATTTGTTTTATTTGAATGTCTGTGGAGAAACTGAAA
TACAGTTCTGTAATAAAAAACAAGCTGCAGTTTGCCAAGTGAAAAAGAGCGATACCTCTCAAGTCAAAGCAGCAGGAAGATACCACAATC
AGACCCTCCGATATTCGGATGGAGACCTCACCTTGATATATTTTGGAGGTGATGAATGCAGCTCAGGGTTTCAGCGGATGAGCGTCATAA
ACTTTGAGTGCAATAAAACCGCAGGTAACGATGGGAAAGGAACTCCTGTATTCACAGGGGAGGTTGACTGCACCTACTTCTTCACATGGG
ACACGGAATACGCCTGTGTTAAGGAGAAGGAAGACCTCCTCTGCGGTGCCACCGACGGGAAGAAGCGCTATGACCTGTCCGCGCTGGTCC
GCCATGCAGAACCAGAGCAGAATTGGGAAGCTGTGGATGGCAGTCAGACGGAAACAGAGAAGAAGCATTTTTTCATTAATATTTGTCACA
GAGTGCTGCAGGAAGGCAAGGCACGAGGGTGTCCCGAGGACGCGGCAGTGTGTGCAGTGGATAAAAATGGAAGTAAAAATCTGGGAAAAT
TTATTTCCTCTCCCATGAAAGAGAAAGGAAACATTCAACTCTCTTATTCAGATGGTGATGATTGTGGTCATGGCAAGAAAATTAAAACTA
ATATCACACTTGTATGCAAGCCAGGTGATCTGGAAAGTGCACCAGTGTTGAGAACTTCTGGGGAAGGCGGTTGCTTTTATGAGTTTGAGT
GGCACACAGCTGCGGCCTGTGTGCTGTCTAAGACAGAAGGGGAGAACTGCACGGTCTTTGACTCCCAGGCAGGGTTTTCTTTTGACTTAT
CACCTCTCACAAAGAAAAATGGTGCCTATAAAGTTGAGACAAAGAAGTATGACTTTTATATAAATGTGTGTGGCCCGGTGTCTGTGAGCC
CCTGTCAGCCAGACTCAGGAGCCTGCCAGGTGGCAAAAAGTGATGAGAAGACTTGGAACTTGGGTCTGAGTAATGCGAAGCTTTCATATT
ATGATGGGATGATCCAACTGAACTACAGAGGCGGCACACCCTATAACAATGAAAGACACACACCGAGAGCTACGCTCATCACCTTTCTCT
GTGATCGAGACGCGGGAGTGGGCTTCCCTGAATATCAGGAAGAGGATAACTCCACCTACAACTTCCGGTGGTACACCAGCTATGCCTGCC
CGGAGGAGCCCCTGGAATGCGTAGTGACCGACCCCTCCACGCTGGAGCAGTACGACCTCTCCAGTCTGGCAAAATCTGAAGGTGGCCTTG
GAGGAAACTGGTATGCCATGGACAACTCAGGGGAACATGTCACGTGGAGGAAATACTACATTAACGTGTGTCGGCCTCTGAATCCAGTGC
CGGGCTGCAACCGATATGCATCGGCTTGCCAGATGAAGTATGAAAAAGATCAGGGCTCCTTCACTGAAGTGGTTTCCATCAGTAACTTGG
GAATGGCAAAGACCGGCCCGGTGGTTGAGGACAGCGGCAGCCTCCTTCTGGAATACGTGAATGGGTCGGCCTGCACCACCAGCGATGGCA
GACAGACCACATATACCACGAGGATCCATCTCGTCTGCTCCAGGGGCAGGCTGAACAGCCACCCCATCTTTTCTCTCAACTGGGAGTGTG
TGGTCAGTTTCCTGTGGAACACAGAGGCTGCCTGTCCCATTCAGACAACGACGGATACAGACCAGGCTTGCTCTATAAGGGATCCCAACA
GTGGATTTGTGTTTAATCTTAATCCGCTAAACAGTTCGCAAGGATATAACGTCTCTGGCATTGGGAAGATTTTTATGTTTAATGTCTGCG
GCACAATGCCTGTCTGTGGGACCATCCTGGGAAAACCTGCTTCTGGCTGTGAGGCAGAAACCCAAACTGAAGAGCTCAAGAATTGGAAGC
CAGCAAGGCCAGTCGGAATTGAGAAAAGCCTCCAGCTGTCCACAGAGGGCTTCATCACTCTGACCTACAAAGGGCCTCTCTCTGCCAAAG
GTACCGCTGATGCTTTTATCGTCCGCTTTGTTTGCAATGATGATGTTTACTCAGGGCCCCTCAAATTCCTGCATCAAGATATCGACTCTG
GGCAAGGGATCCGAAACACTTACTTTGAGTTTGAAACCGCGTTGGCCTGTGTTCCTTCTCCAGTGGACTGCCAAGTCACCGACCTGGCTG
GAAATGAGTACGACCTGACTGGCCTAAGCACAGTCAGGAAACCTTGGACGGCTGTTGACACCTCTGTCGATGGGAGAAAGAGGACTTTCT
ATTTGAGCGTTTGCAATCCTCTCCCTTACATTCCTGGATGCCAGGGCAGCGCAGTGGGGTCTTGCTTAGTGTCAGAAGGCAATAGCTGGA
ATCTGGGTGTGGTGCAGATGAGTCCCCAAGCCGCGGCGAATGGATCTTTGAGCATCATGTATGTCAACGGTGACAAGTGTGGGAACCAGC
GCTTCTCCACCAGGATCACGTTTGAGTGTGCTCAGATATCGGGCTCACCAGCATTTCAGCTTCAGGATGGTTGTGAGTACGTGTTTATCT
GGAGAACTGTGGAAGCCTGTCCCGTTGTCAGAGTGGAAGGGGACAACTGTGAGGTGAAAGACCCAAGGCATGGCAACTTGTATGACCTGA
AGCCCCTGGGCCTCAACGACACCATCGTGAGCGCTGGCGAATACACTTATTACTTCCGGGTCTGTGGGAAGCTTTCCTCAGACGTCTGCC
CCACAAGTGACAAGTCCAAGGTGGTCTCCTCATGTCAGGAAAAGCGGGAACCGCAGGGATTTCACAAAGTGGCAGGTCTCCTGACTCAGA
AGCTAACTTATGAAAATGGCTTGTTAAAAATGAACTTCACGGGGGGGGACACTTGCCATAAGGTTTATCAGCGCTCCACAGCCATCTTCT
TCTACTGTGACCGCGGCACCCAGCGGCCAGTATTTCTAAAGGAGACTTCAGATTGTTCCTACTTGTTTGAGTGGCGAACGCAGTATGCCT
GCCCACCTTTCGATCTGACTGAATGTTCATTCAAAGATGGGGCTGGCAACTCCTTCGACCTCTCGTCCCTGTCAAGGTACAGTGACAACT
GGGAAGCCATCACTGGGACGGGGGACCCGGAGCACTACCTCATCAATGTCTGCAAGTCTCTGGCCCCGCAGGCTGGCACTGAGCCGTGCC
CTCCAGAAGCAGCCGCGTGTCTGCTGGGTGGCTCCAAGCCCGTGAACCTCGGCAGGGTAAGGGACGGACCTCAGTGGAGAGATGGCATAA
TTGTCCTGAAATACGTTGATGGCGACTTATGTCCAGATGGGATTCGGAAAAAGTCAACCACCATCCGATTCACCTGCAGCGAGAGCCAAG
TGAACTCCAGGCCCATGTTCATCAGCGCCGTGGAGGACTGTGAGTACACCTTTGCCTGGCCCACAGCCACAGCCTGTCCCATGAAGAGCA
ACGAGCATGATGACTGCCAGGTCACCAACCCAAGCACAGGACACCTGTTTGATCTGAGCTCCTTAAGTGGCAGGGCGGGATTCACAGCTG
CTTACAGCGAGAAGGGGTTGGTTTACATGAGCATCTGTGGGGAGAATGAAAACTGCCCTCCTGGCGTGGGGGCCTGCTTTGGACAGACCA
GGATTAGCGTGGGCAAGGCCAACAAGAGGCTGAGATACGTGGACCAGGTCCTGCAGCTGGTGTACAAGGATGGGTCCCCTTGTCCCTCCA
AATCCGGCCTGAGCTATAAGAGTGTGATCAGTTTCGTGTGCAGGCCTGAGGCCAGGCCAACCAATAGGCCCATGCTCATCTCCCTGGACA
AGCAGACATGCACTCTCTTCTTCTCCTGGCACACGCCGCTGGCCTGCGAGCAAGCGACCGAATGTTCCGTGAGGAATGGAAGCTCTATTG
TTGACTTGTCTCCCCTTATTCATCGCACTGGTGGTTATGAGGCTTATGATGAGAGTGAGGATGATGCCTCCGATACCAACCCTGATTTCT
ACATCAATATTTGTCAGCCACTAAATCCCATGCACGGAGTGCCCTGTCCTGCCGGAGCCGCTGTGTGCAAAGTTCCTATTGATGGTCCCC
CCATAGATATCGGCCGGGTAGCAGGACCACCAATACTCAATCCAATAGCAAATGAGATTTACTTGAATTTTGAAAGCAGTACTCCTTGCT
TAGCGGACAAGCATTTCAACTACACCTCGCTCATCGCGTTTCACTGTAAGAGAGGTGTGAGCATGGGAACGCCTAAGCTGTTAAGGACCA
GCGAGTGCGACTTTGTGTTCGAATGGGAGACTCCTGTCGTCTGTCCTGATGAAGTGAGGATGGATGGCTGTACCCTGACAGATGAGCAGC
TCCTCTACAGCTTCAACTTGTCCAGCCTTTCCACGAGCACCTTTAAGGTGACTCGCGACTCGCGCACCTACAGCGTTGGGGTGTGCACCT
TTGCAGTCGGGCCAGAACAAGGAGGCTGTAAGGACGGAGGAGTCTGTCTGCTCTCAGGCACCAAGGGGGCATCCTTTGGACGGCTGCAAT
CAATGAAACTGGATTACAGGCACCAGGATGAAGCGGTCGTTTTAAGTTACGTGAATGGTGATCGTTGCCCTCCAGAAACCGATGACGGCG
TCCCCTGTGTCTTCCCCTTCATATTCAATGGGAAGAGCTACGAGGAGTGCATCATAGAGAGCAGGGCGAAGCTGTGGTGTAGCACAACTG
CGGACTACGACAGAGACCACGAGTGGGGCTTCTGCAGACACTCAAACAGCTACCGGACATCCAGCATCATATTTAAGTGTGATGAAGATG
AGGACATTGGGAGGCCACAAGTCTTCAGTGAAGTGCGTGGGTGTGATGTGACATTTGAGTGGAAAACAAAAGTTGTCTGCCCTCCAAAGA
AGTTGGAGTGCAAATTCGTCCAGAAACACAAAACCTACGACCTGCGGCTGCTCTCCTCTCTCACCGGGTCCTGGTCCCTCGTCCACAACG
GAGTCTCGTACTATATAAATCTGTGCCAGAAAATATATAAAGGGCCCCTGGGCTGCTCTGAAAGGGCCAGCATTTGCAGAAGGACCACAA
CTGGTGACGTCCAGGTCCTGGGACTCGTTCACACGCAGAAGCTGGGTGTCATAGGTGACAAAGTTGTTGTCACGTACTCCAAAGGTTATC
CGTGTGGTGGAAATAAGACCGCATCCTCCGTGATAGAATTGACCTGTACAAAGACGGTGGGCAGACCTGCATTCAAGAGGTTTGATATCG
ACAGCTGCACTTACTACTTCAGCTGGGACTCCCGGGCTGCCTGCGCCGTGAAGCCTCAGGAGGTGCAGATGGTGAATGGGACCATCACCA
ACCCTATAAATGGCAAGAGCTTCAGCCTCGGAGATATTTATTTTAAGCTGTTCAGAGCCTCTGGGGACATGAGGACCAATGGGGACAACT
ACCTGTATGAGATCCAACTTTCCTCCATCACAAGCTCCAGAAACCCGGCGTGCTCTGGAGCCAACATATGCCAGGTGAAGCCCAACGATC
AGCACTTCAGTCGGAAAGTTGGAACCTCTGACAAGACCAAGTACTACCTTCAAGACGGCGATCTCGATGTCGTGTTTGCCTCTTCCTCTA
AGTGCGGAAAGGATAAGACCAAGTCTGTTTCTTCCACCATCTTCTTCCACTGTGACCCTCTGGTGGAGGACGGGATCCCCGAGTTCAGTC
ACGAGACTGCCGACTGCCAGTACCTCTTCTCTTGGTACACCTCAGCCGTGTGTCCTCTGGGGGTGGGCTTTGACAGCGAGAATCCCGGGG
ACGACGGGCAGATGCACAAGGGGCTGTCAGAACGGAGCCAGGCAGTCGGCGCGGTGCTCAGCCTGCTGCTGGTGGCGCTCACCTGCTGCC
TGCTGGCCCTGTTGCTCTACAAGAAGGAGAGGAGGGAAACAGTGATAAGTAAGCTGACCACTTGCTGTAGGAGAAGTTCCAACGTGTCCT
ACAAATACTCAAAGGTGAATAAGGAAGAAGAGACAGATGAGAATGAAACAGAGTGGCTGATGGAAGAGATCCAGCTGCCTCCTCCACGGC
AGGGAAAGGAAGGGCAGGAGAACGGCCATATTACCACCAAGTCAGTGAAAGCCCTCAGCTCCCTGCATGGGGATGACCAGGACAGTGAGG
ATGAGGTTCTGACCATCCCAGAGGTGAAAGTTCACTCGGGCAGGGGAGCTGGGGCAGAGAGCTCCCACCCAGTGAGAAACGCACAGAGCA
ATGCCCTTCAGGAGCGTGAGGACGATAGGGTGGGGCTGGTCAGGGGTGAGAAGGCGAGGAAAGGGAAGTCCAGCTCTGCACAGCAGAAGA
CAGTGAGCTCCACCAAGCTGGTGTCCTTCCATGACGACAGCGACGAGGACCTCTTACACATCTGACTCCGCAGTGCCTGCAGGGGAGCAC
GGAGCCGCGGGACAGCCAAGCACCTCCAACCAAATAAGACTTCCACTCGATGATGCTTCTATAATTTTGCCTTTAACAGAAACTTTCAAA
AGGGAAGAGTTTTTGTGATGGGGGAGAGGGTGAAGGAGGTCAGGCCCCACTCCTTCCTGATTGTTTACAGTCATTGGAATAAGGCATGGC
TCAGATCGGCCACAGGGCGGTACCTTGTGCCCAGGGTTTTGCCCCAAGTCCTCATTTAAAAGCATAAGGCCGGACGCATCTCAAAACAGA
GGGCTGCATTCGAAGAAACCCTTGCTGCTTTAGTCCCGATAGGGTATTTGACCCCGATATATTTTAGCATTTTAATTCTCTCCCCCTATT
TATTGACTTTGACAATTACTCAGGTTTGAGAAAAAGGAAAAAAAAACAGCCACCGTTTCTTCCTGCCAGCAGGGGTGTGATGTACCAGTT
TGTCCATCTTGAGATGGTGAGGCTGTCAGTGTATGGGGCAGCTTCCGGCGGGATGTTGAACTGGTCATTAATGTGTCCCCTGAGTTGGAG
CTCATTCTGTCTCTTTTCTCTTTTGCTTTCTGTTTCTTAAGGGCACACACACGTGCGTGCGAGCACACACACACATACGTGCACAGGGTC
CCCGAGTGCCTAGGTTTTGGAGAGTTTGCCTGTTCTATGCCTTTAGTCAGGAATGGCTGCACCTTTTTGCATGATATCTTCAAGCCTGGG
CGTACAGAGCACATTTGTCAGTATTTTTGCCGGCTGGTGAATTCAAACAACCTGCCCAAAGATTGATTTGTGTGTTTGTGTGTGTGTGTG
TGTGTGTGTGTGTGTGTGTGAGTGGAGTTGAGGTGTCAGAGAAAATGAATTTTTTCCAGATTTGGGGTATAGGTCTCATCTCTTCAGGTT
CTCATGATACCACCTTTACTGTGCTTATTTTTTTAAGAAAAAAGTGTTGATCAACCATTCGACCTATAAGAAGCCTTAATTTGCACAGTG
TGTGACTTACAGAAACTGCATGAAAAATCATGGGCCAGAGCCTCGGCCCTAGCATTGCACTTGGCCTCATGCTGGAGGGAGGCTGGGCGG
GTACAGCGCGGAGGAGGAGGGAGGCCAGGCGGGCATGGCGTGGAGGAGGAGGGAGGCCGGGCGGTCACAGCATGGAGGAGGAGGGAGGCG
CTGCTGGTGTTCTTATTCTGGCGGCAGCGCCTTTCCTGCCATGTTTAGTGAATGACTTTTCTCGCATTGTAGAATTGTATATAGACTCTG
GTGTTCTATTGCTGAGAAGCAAACCGCCCTGCAGCATCCCTCAGCCTGTACCGGTTTGGCTGGCTTGTTTGATTTCAACATGAGTGTATT
TTTTAAAATTGATTTTTCTCTTCATTTTTTTTTCAATCAACTTTACTGTAATATAAAGTATTCAACAATTTCAATAAAAGATAAATTATT

>82111_82111_1_SKIV2L2-IGF2R_SKIV2L2_chr5_54603975_ENST00000230640_IGF2R_chr6_160412216_ENST00000356956_length(amino acids)=2493AA_BP=52
MLSLLPKMADAFGDELFSVFEGDSTTAAGTKKDKEKDKGKWKGPPGSADKAGYTWEAVDTKNNVLYKINICGSVDIVQCGPSSAVCMHDL
KTRTYHSVGDSVLRSATRSLLEFNTTVSCDQQGTNHRVQSSIAFLCGKTLGTPEFVTATECVHYFEWRTTAACKKDIFKANKEVPCYVFD
EELRKHDLNPLIKLSGAYLVDDSDPDTSLFINVCRDIDTLRDPGSQLRACPPGTAACLVRGHQAFDVGQPRDGLKLVRKDRLVLSYVREE
AGKLDFCDGHSPAVTITFVCPSERREGTIPKLTAKSNCRYEIEWITEYACHRDYLESKTCSLSGEQQDVSIDLTPLAQSGGSSYISDGKE
YLFYLNVCGETEIQFCNKKQAAVCQVKKSDTSQVKAAGRYHNQTLRYSDGDLTLIYFGGDECSSGFQRMSVINFECNKTAGNDGKGTPVF
TGEVDCTYFFTWDTEYACVKEKEDLLCGATDGKKRYDLSALVRHAEPEQNWEAVDGSQTETEKKHFFINICHRVLQEGKARGCPEDAAVC
AVDKNGSKNLGKFISSPMKEKGNIQLSYSDGDDCGHGKKIKTNITLVCKPGDLESAPVLRTSGEGGCFYEFEWHTAAACVLSKTEGENCT
VFDSQAGFSFDLSPLTKKNGAYKVETKKYDFYINVCGPVSVSPCQPDSGACQVAKSDEKTWNLGLSNAKLSYYDGMIQLNYRGGTPYNNE
RHTPRATLITFLCDRDAGVGFPEYQEEDNSTYNFRWYTSYACPEEPLECVVTDPSTLEQYDLSSLAKSEGGLGGNWYAMDNSGEHVTWRK
YYINVCRPLNPVPGCNRYASACQMKYEKDQGSFTEVVSISNLGMAKTGPVVEDSGSLLLEYVNGSACTTSDGRQTTYTTRIHLVCSRGRL
NSHPIFSLNWECVVSFLWNTEAACPIQTTTDTDQACSIRDPNSGFVFNLNPLNSSQGYNVSGIGKIFMFNVCGTMPVCGTILGKPASGCE
AETQTEELKNWKPARPVGIEKSLQLSTEGFITLTYKGPLSAKGTADAFIVRFVCNDDVYSGPLKFLHQDIDSGQGIRNTYFEFETALACV
PSPVDCQVTDLAGNEYDLTGLSTVRKPWTAVDTSVDGRKRTFYLSVCNPLPYIPGCQGSAVGSCLVSEGNSWNLGVVQMSPQAAANGSLS
IMYVNGDKCGNQRFSTRITFECAQISGSPAFQLQDGCEYVFIWRTVEACPVVRVEGDNCEVKDPRHGNLYDLKPLGLNDTIVSAGEYTYY
FRVCGKLSSDVCPTSDKSKVVSSCQEKREPQGFHKVAGLLTQKLTYENGLLKMNFTGGDTCHKVYQRSTAIFFYCDRGTQRPVFLKETSD
CSYLFEWRTQYACPPFDLTECSFKDGAGNSFDLSSLSRYSDNWEAITGTGDPEHYLINVCKSLAPQAGTEPCPPEAAACLLGGSKPVNLG
RVRDGPQWRDGIIVLKYVDGDLCPDGIRKKSTTIRFTCSESQVNSRPMFISAVEDCEYTFAWPTATACPMKSNEHDDCQVTNPSTGHLFD
LSSLSGRAGFTAAYSEKGLVYMSICGENENCPPGVGACFGQTRISVGKANKRLRYVDQVLQLVYKDGSPCPSKSGLSYKSVISFVCRPEA
RPTNRPMLISLDKQTCTLFFSWHTPLACEQATECSVRNGSSIVDLSPLIHRTGGYEAYDESEDDASDTNPDFYINICQPLNPMHGVPCPA
GAAVCKVPIDGPPIDIGRVAGPPILNPIANEIYLNFESSTPCLADKHFNYTSLIAFHCKRGVSMGTPKLLRTSECDFVFEWETPVVCPDE
VRMDGCTLTDEQLLYSFNLSSLSTSTFKVTRDSRTYSVGVCTFAVGPEQGGCKDGGVCLLSGTKGASFGRLQSMKLDYRHQDEAVVLSYV
NGDRCPPETDDGVPCVFPFIFNGKSYEECIIESRAKLWCSTTADYDRDHEWGFCRHSNSYRTSSIIFKCDEDEDIGRPQVFSEVRGCDVT
FEWKTKVVCPPKKLECKFVQKHKTYDLRLLSSLTGSWSLVHNGVSYYINLCQKIYKGPLGCSERASICRRTTTGDVQVLGLVHTQKLGVI
GDKVVVTYSKGYPCGGNKTASSVIELTCTKTVGRPAFKRFDIDSCTYYFSWDSRAACAVKPQEVQMVNGTITNPINGKSFSLGDIYFKLF
RASGDMRTNGDNYLYEIQLSSITSSRNPACSGANICQVKPNDQHFSRKVGTSDKTKYYLQDGDLDVVFASSSKCGKDKTKSVSSTIFFHC
DPLVEDGIPEFSHETADCQYLFSWYTSAVCPLGVGFDSENPGDDGQMHKGLSERSQAVGAVLSLLLVALTCCLLALLLYKKERRETVISK
LTTCCRRSSNVSYKYSKVNKEEETDENETEWLMEEIQLPPPRQGKEGQENGHITTKSVKALSSLHGDDQDSEDEVLTIPEVKVHSGRGAG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for SKIV2L2-IGF2R

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for SKIV2L2-IGF2R

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for SKIV2L2-IGF2R

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source