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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SKIV2L-SKIV2L (FusionGDB2 ID:82147)

Fusion Gene Summary for SKIV2L-SKIV2L

check button Fusion gene summary
Fusion gene informationFusion gene name: SKIV2L-SKIV2L
Fusion gene ID: 82147
HgeneTgene
Gene symbol

SKIV2L

SKIV2L

Gene ID

6499

6499

Gene nameSki2 like RNA helicaseSki2 like RNA helicase
Synonyms170A|DDX13|HLP|SKI2|SKI2W|SKIV2|SKIV2L1|THES2170A|DDX13|HLP|SKI2|SKI2W|SKIV2|SKIV2L1|THES2
Cytomap

6p21.33

6p21.33

Type of geneprotein-codingprotein-coding
Descriptionhelicase SKI2WSKI2 homolog, superkiller viralicidic activity 2-likehelicase-like proteinsuperkiller viralicidic activity 2-likehelicase SKI2WSKI2 homolog, superkiller viralicidic activity 2-likehelicase-like proteinsuperkiller viralicidic activity 2-like
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000375394, ENST00000544581, 
ENST00000383336, ENST00000412823, 
ENST00000421789, ENST00000429465, 
ENST00000448219, ENST00000461360, 
ENST00000466463, ENST00000471547, 
ENST00000476338, ENST00000480914, 
ENST00000488648, 		ENST00000383336, 
ENST00000412823, ENST00000421789, 
ENST00000429465, ENST00000448219, 
ENST00000461360, ENST00000466463, 
ENST00000471547, ENST00000476338, 
ENST00000480914, ENST00000488648, 
ENST00000544581, ENST00000375394, 
Fusion gene scores* DoF score6 X 5 X 5=1501 X 1 X 1=1
# samples 61
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: SKIV2L [Title/Abstract] AND SKIV2L [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSKIV2L(31936170)-SKIV2L(31937080), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across SKIV2L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SKIV2L (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ACK724897SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-


Top

Fusion Gene ORF analysis for SKIV2L-SKIV2L

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000375394ENST00000383336SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000375394ENST00000412823SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000375394ENST00000421789SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000375394ENST00000429465SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000375394ENST00000448219SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000375394ENST00000461360SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000375394ENST00000466463SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000375394ENST00000471547SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000375394ENST00000476338SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000375394ENST00000480914SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000375394ENST00000488648SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000375394ENST00000544581SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000544581ENST00000383336SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000544581ENST00000412823SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000544581ENST00000421789SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000544581ENST00000429465SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000544581ENST00000448219SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000544581ENST00000461360SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000544581ENST00000466463SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000544581ENST00000471547SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000544581ENST00000476338SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000544581ENST00000480914SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000544581ENST00000488648SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
5CDS-intronENST00000544581ENST00000544581SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
In-frameENST00000375394ENST00000375394SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
In-frameENST00000544581ENST00000375394SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-3CDSENST00000383336ENST00000375394SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-3CDSENST00000412823ENST00000375394SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-3CDSENST00000421789ENST00000375394SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-3CDSENST00000429465ENST00000375394SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-3CDSENST00000448219ENST00000375394SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-3CDSENST00000461360ENST00000375394SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-3CDSENST00000466463ENST00000375394SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-3CDSENST00000471547ENST00000375394SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-3CDSENST00000476338ENST00000375394SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-3CDSENST00000480914ENST00000375394SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-3CDSENST00000488648ENST00000375394SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000383336ENST00000383336SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000383336ENST00000412823SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000383336ENST00000421789SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000383336ENST00000429465SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000383336ENST00000448219SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000383336ENST00000461360SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000383336ENST00000466463SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000383336ENST00000471547SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000383336ENST00000476338SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000383336ENST00000480914SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000383336ENST00000488648SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000383336ENST00000544581SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000412823ENST00000383336SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000412823ENST00000412823SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000412823ENST00000421789SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000412823ENST00000429465SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000412823ENST00000448219SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000412823ENST00000461360SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000412823ENST00000466463SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000412823ENST00000471547SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000412823ENST00000476338SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000412823ENST00000480914SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000412823ENST00000488648SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000412823ENST00000544581SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000421789ENST00000383336SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000421789ENST00000412823SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000421789ENST00000421789SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000421789ENST00000429465SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000421789ENST00000448219SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000421789ENST00000461360SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000421789ENST00000466463SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000421789ENST00000471547SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000421789ENST00000476338SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000421789ENST00000480914SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000421789ENST00000488648SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000421789ENST00000544581SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000429465ENST00000383336SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000429465ENST00000412823SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000429465ENST00000421789SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000429465ENST00000429465SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000429465ENST00000448219SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000429465ENST00000461360SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000429465ENST00000466463SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000429465ENST00000471547SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000429465ENST00000476338SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000429465ENST00000480914SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000429465ENST00000488648SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000429465ENST00000544581SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000448219ENST00000383336SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000448219ENST00000412823SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000448219ENST00000421789SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000448219ENST00000429465SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000448219ENST00000448219SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000448219ENST00000461360SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000448219ENST00000466463SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000448219ENST00000471547SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000448219ENST00000476338SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000448219ENST00000480914SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000448219ENST00000488648SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000448219ENST00000544581SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000461360ENST00000383336SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000461360ENST00000412823SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000461360ENST00000421789SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000461360ENST00000429465SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000461360ENST00000448219SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000461360ENST00000461360SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000461360ENST00000466463SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000461360ENST00000471547SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000461360ENST00000476338SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000461360ENST00000480914SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000461360ENST00000488648SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000461360ENST00000544581SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000466463ENST00000383336SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000466463ENST00000412823SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000466463ENST00000421789SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000466463ENST00000429465SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000466463ENST00000448219SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000466463ENST00000461360SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000466463ENST00000466463SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000466463ENST00000471547SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000466463ENST00000476338SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000466463ENST00000480914SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000466463ENST00000488648SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000466463ENST00000544581SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000471547ENST00000383336SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000471547ENST00000412823SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000471547ENST00000421789SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000471547ENST00000429465SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000471547ENST00000448219SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000471547ENST00000461360SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000471547ENST00000466463SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000471547ENST00000471547SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000471547ENST00000476338SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000471547ENST00000480914SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000471547ENST00000488648SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000471547ENST00000544581SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000476338ENST00000383336SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000476338ENST00000412823SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000476338ENST00000421789SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000476338ENST00000429465SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000476338ENST00000448219SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000476338ENST00000461360SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000476338ENST00000466463SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000476338ENST00000471547SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000476338ENST00000476338SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000476338ENST00000480914SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000476338ENST00000488648SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000476338ENST00000544581SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000480914ENST00000383336SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000480914ENST00000412823SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000480914ENST00000421789SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000480914ENST00000429465SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000480914ENST00000448219SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000480914ENST00000461360SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000480914ENST00000466463SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000480914ENST00000471547SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000480914ENST00000476338SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000480914ENST00000480914SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000480914ENST00000488648SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000480914ENST00000544581SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000488648ENST00000383336SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000488648ENST00000412823SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000488648ENST00000421789SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000488648ENST00000429465SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000488648ENST00000448219SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000488648ENST00000461360SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000488648ENST00000466463SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000488648ENST00000471547SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000488648ENST00000476338SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000488648ENST00000480914SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000488648ENST00000488648SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-
intron-intronENST00000488648ENST00000544581SKIV2Lchr6

31936170

-SKIV2Lchr6

31937080

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SKIV2L-SKIV2L


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for SKIV2L-SKIV2L


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:31936170/chr6:31937080)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000375394028319_47501247.0DomainHelicase ATP-binding
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000375394028585_75501247.0DomainHelicase C-terminal
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000383336028319_47501247.0DomainHelicase ATP-binding
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000383336028585_75501247.0DomainHelicase C-terminal
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000412823028319_47501247.0DomainHelicase ATP-binding
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000412823028585_75501247.0DomainHelicase C-terminal
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000421789028319_47501247.0DomainHelicase ATP-binding
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000421789028585_75501247.0DomainHelicase C-terminal
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000429465028319_47501247.0DomainHelicase ATP-binding
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000429465028585_75501247.0DomainHelicase C-terminal
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000448219028319_47501247.0DomainHelicase ATP-binding
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000448219028585_75501247.0DomainHelicase C-terminal
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000375394028423_42601247.0MotifNote=DEVH box
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000383336028423_42601247.0MotifNote=DEVH box
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000412823028423_42601247.0MotifNote=DEVH box
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000421789028423_42601247.0MotifNote=DEVH box
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000429465028423_42601247.0MotifNote=DEVH box
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000448219028423_42601247.0MotifNote=DEVH box
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000375394028332_33901247.0Nucleotide bindingATP
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000383336028332_33901247.0Nucleotide bindingATP
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000412823028332_33901247.0Nucleotide bindingATP
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000421789028332_33901247.0Nucleotide bindingATP
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000429465028332_33901247.0Nucleotide bindingATP
TgeneSKIV2Lchr6:31936170chr6:31937080ENST00000448219028332_33901247.0Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000375394-128319_47501247.0DomainHelicase ATP-binding
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000375394-128585_75501247.0DomainHelicase C-terminal
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000383336-128319_47501247.0DomainHelicase ATP-binding
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000383336-128585_75501247.0DomainHelicase C-terminal
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000412823-128319_47501247.0DomainHelicase ATP-binding
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000412823-128585_75501247.0DomainHelicase C-terminal
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000421789-128319_47501247.0DomainHelicase ATP-binding
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000421789-128585_75501247.0DomainHelicase C-terminal
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000429465-128319_47501247.0DomainHelicase ATP-binding
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000429465-128585_75501247.0DomainHelicase C-terminal
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000448219-128319_47501247.0DomainHelicase ATP-binding
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000448219-128585_75501247.0DomainHelicase C-terminal
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000375394-128423_42601247.0MotifNote=DEVH box
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000383336-128423_42601247.0MotifNote=DEVH box
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000412823-128423_42601247.0MotifNote=DEVH box
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000421789-128423_42601247.0MotifNote=DEVH box
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000429465-128423_42601247.0MotifNote=DEVH box
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000448219-128423_42601247.0MotifNote=DEVH box
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000375394-128332_33901247.0Nucleotide bindingATP
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000383336-128332_33901247.0Nucleotide bindingATP
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000412823-128332_33901247.0Nucleotide bindingATP
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000421789-128332_33901247.0Nucleotide bindingATP
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000429465-128332_33901247.0Nucleotide bindingATP
HgeneSKIV2Lchr6:31936170chr6:31937080ENST00000448219-128332_33901247.0Nucleotide bindingATP


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Fusion Gene Sequence for SKIV2L-SKIV2L


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SKIV2L-SKIV2L


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SKIV2L-SKIV2L


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SKIV2L-SKIV2L


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource