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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLBP-ADD1 (FusionGDB2 ID:82183)

Fusion Gene Summary for SLBP-ADD1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLBP-ADD1
Fusion gene ID: 82183
HgeneTgene
Gene symbol

SLBP

ADD1

Gene ID

7884

118

Gene namestem-loop binding proteinadducin 1
SynonymsHBPADDA
Cytomap

4p16.3

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionhistone RNA hairpin-binding proteinhairpin binding protein, histonehistone binding proteinhistone stem-loop binding proteinstem-loop (histone) binding proteinalpha-adducinadducin 1 (alpha)erythrocyte adducin alpha subunit
Modification date2020031320200322
UniProtAcc.

P35611

Ensembl transtripts involved in fusion geneENST00000318386, ENST00000488267, 
ENST00000489418, ENST00000429429, 
ENST00000538860, ENST00000264758, 
ENST00000355842, ENST00000398123, 
ENST00000398125, ENST00000398129, 
ENST00000446856, ENST00000503455, 
ENST00000513328, 
Fusion gene scores* DoF score5 X 5 X 6=15011 X 10 X 6=660
# samples 912
** MAII scorelog2(9/150*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/660*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLBP [Title/Abstract] AND ADD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLBP(1713600)-ADD1(2896308), # samples:1
SLBP(1713601)-ADD1(2896309), # samples:1
Anticipated loss of major functional domain due to fusion event.SLBP-ADD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
SLBP-ADD1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSLBP

GO:0051028

mRNA transport

19155325

TgeneADD1

GO:0032092

positive regulation of protein binding

3693401|7642559

TgeneADD1

GO:0051016

barbed-end actin filament capping

8626479

TgeneADD1

GO:0051017

actin filament bundle assembly

3693401

TgeneADD1

GO:0071277

cellular response to calcium ion

25978380

TgeneADD1

GO:1903142

positive regulation of establishment of endothelial barrier

25978380

TgeneADD1

GO:1903393

positive regulation of adherens junction organization

25978380


check buttonFusion gene breakpoints across SLBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check buttonFusion gene breakpoints across ADD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-CF-A47V-01ASLBPchr4

1713601

-ADD1chr4

2896309

+
ChimerDB4BLCATCGA-CF-A47VSLBPchr4

1713600

-ADD1chr4

2896308

+


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Fusion Gene ORF analysis for SLBP-ADD1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000318386ENST00000538860SLBPchr4

1713601

-ADD1chr4

2896309

+
5CDS-intronENST00000318386ENST00000538860SLBPchr4

1713600

-ADD1chr4

2896308

+
5CDS-intronENST00000488267ENST00000538860SLBPchr4

1713601

-ADD1chr4

2896309

+
5CDS-intronENST00000488267ENST00000538860SLBPchr4

1713600

-ADD1chr4

2896308

+
5CDS-intronENST00000489418ENST00000538860SLBPchr4

1713601

-ADD1chr4

2896309

+
5CDS-intronENST00000489418ENST00000538860SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000318386ENST00000264758SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000318386ENST00000264758SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000318386ENST00000355842SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000318386ENST00000355842SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000318386ENST00000398123SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000318386ENST00000398123SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000318386ENST00000398125SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000318386ENST00000398125SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000318386ENST00000398129SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000318386ENST00000398129SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000318386ENST00000446856SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000318386ENST00000446856SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000318386ENST00000503455SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000318386ENST00000503455SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000318386ENST00000513328SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000318386ENST00000513328SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000488267ENST00000264758SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000488267ENST00000264758SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000488267ENST00000355842SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000488267ENST00000355842SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000488267ENST00000398123SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000488267ENST00000398123SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000488267ENST00000398125SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000488267ENST00000398125SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000488267ENST00000398129SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000488267ENST00000398129SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000488267ENST00000446856SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000488267ENST00000446856SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000488267ENST00000503455SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000488267ENST00000503455SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000488267ENST00000513328SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000488267ENST00000513328SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000489418ENST00000264758SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000489418ENST00000264758SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000489418ENST00000355842SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000489418ENST00000355842SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000489418ENST00000398123SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000489418ENST00000398123SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000489418ENST00000398125SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000489418ENST00000398125SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000489418ENST00000398129SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000489418ENST00000398129SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000489418ENST00000446856SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000489418ENST00000446856SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000489418ENST00000503455SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000489418ENST00000503455SLBPchr4

1713600

-ADD1chr4

2896308

+
Frame-shiftENST00000489418ENST00000513328SLBPchr4

1713601

-ADD1chr4

2896309

+
Frame-shiftENST00000489418ENST00000513328SLBPchr4

1713600

-ADD1chr4

2896308

+
intron-3CDSENST00000429429ENST00000264758SLBPchr4

1713601

-ADD1chr4

2896309

+
intron-3CDSENST00000429429ENST00000264758SLBPchr4

1713600

-ADD1chr4

2896308

+
intron-3CDSENST00000429429ENST00000355842SLBPchr4

1713601

-ADD1chr4

2896309

+
intron-3CDSENST00000429429ENST00000355842SLBPchr4

1713600

-ADD1chr4

2896308

+
intron-3CDSENST00000429429ENST00000398123SLBPchr4

1713601

-ADD1chr4

2896309

+
intron-3CDSENST00000429429ENST00000398123SLBPchr4

1713600

-ADD1chr4

2896308

+
intron-3CDSENST00000429429ENST00000398125SLBPchr4

1713601

-ADD1chr4

2896309

+
intron-3CDSENST00000429429ENST00000398125SLBPchr4

1713600

-ADD1chr4

2896308

+
intron-3CDSENST00000429429ENST00000398129SLBPchr4

1713601

-ADD1chr4

2896309

+
intron-3CDSENST00000429429ENST00000398129SLBPchr4

1713600

-ADD1chr4

2896308

+
intron-3CDSENST00000429429ENST00000446856SLBPchr4

1713601

-ADD1chr4

2896309

+
intron-3CDSENST00000429429ENST00000446856SLBPchr4

1713600

-ADD1chr4

2896308

+
intron-3CDSENST00000429429ENST00000503455SLBPchr4

1713601

-ADD1chr4

2896309

+
intron-3CDSENST00000429429ENST00000503455SLBPchr4

1713600

-ADD1chr4

2896308

+
intron-3CDSENST00000429429ENST00000513328SLBPchr4

1713601

-ADD1chr4

2896309

+
intron-3CDSENST00000429429ENST00000513328SLBPchr4

1713600

-ADD1chr4

2896308

+
intron-intronENST00000429429ENST00000538860SLBPchr4

1713601

-ADD1chr4

2896309

+
intron-intronENST00000429429ENST00000538860SLBPchr4

1713600

-ADD1chr4

2896308

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SLBP-ADD1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLBPchr41713600-ADD1chr42896308+5.63E-070.9999994
SLBPchr41713600-ADD1chr42896308+5.63E-070.9999994
SLBPchr41713600-ADD1chr42896308+5.63E-070.9999994
SLBPchr41713600-ADD1chr42896308+5.63E-070.9999994

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SLBP-ADD1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:1713600/:2896308)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.ADD1

P35611

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Binds to calmodulin.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SLBP-ADD1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SLBP-ADD1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLBP-ADD1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLBP-ADD1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource